|Numéro de publication||US3902501 A|
|Type de publication||Octroi|
|Date de publication||2 sept. 1975|
|Date de dépôt||21 juin 1973|
|Date de priorité||21 juin 1973|
|Numéro de publication||US 3902501 A, US 3902501A, US-A-3902501, US3902501 A, US3902501A|
|Inventeurs||Citron Paul, Dickhudt Eugene A|
|Cessionnaire d'origine||Medtronic Inc|
|Exporter la citation||BiBTeX, EndNote, RefMan|
|Citations de brevets (10), Référencé par (259), Classifications (4)|
|Liens externes: USPTO, Cession USPTO, Espacenet|
United States Patent [191 Citron et al.
[451 Sept. 2, 1975 ENDOCARDIAL ELECTRODE  Inventors: Paul Citron, New Brighton; Eugene A. Dickhudt, St. Paul, both of Minn.
 Assignee: Medtronic, Inc., Minneapolis, Minn.
 Filed: June 21, 1973  Appl. No.: 372,269
 References Cited UNITED STATES PATENTS 2,854,983 10/1958 Baskin 128/349 B 3,348,548 10/1967 Chardack..... 128/419 P 3,397,699 8/1968 Kohl 128/243 3,516,410 6/1970 Hakim 128/350 R 3,568,659 3/1971 Karnegis.... 128/243 3,608,555 9/1971 Greyson 128/348 3,717,151 2/1973 Collett 128/350 R 3,719,190 3/1973 Avery.... 128/418 3,815,608 6/1974 Spinosa et al. 128/349 R 3,835,864 9/1974 Rasor et al 128/418 X OTHER PUBLICATIONS Schaldach, New Pacemaker Electrodes, Trans: Am. Society For Artificial Internal Organs, Vol. 17, 1971,
Wende et al., Neve intrakar dicle Schrittmacherelektrode, Deutsche Medizinisch-e Wochenschrift, Nr. 40, 2, Oct. 1970, pp. 2026-2028.
Pieper, Registration of Phesic Changes of Blood Flowby Means of Catheter Type Flowmeter, Review of Sci. Instr., Vol. 29, No. 11, Nov. 1958, pp. 965-967.
Primary ExaminerRichard A. Gaudet Assistant ExaminerLee S. Cohen Attorney, Agent, or Firm-Lew Schwartz; Wayne A. Sivertson  ABSTRACT A medical electrode uniquely adapted for use as an endocardial electrode. An electrical conductor is encased in a material which is generally inert to body fluids and terminates at an exposed electrically conductive tip. A plurality of pliant tines extend from the electrode adjacent the tip and form an acute angle with the electrode body. Provision is made for holding the tines against the electrode body during insertion while allowing their release when the tip is in position. The released tines cooperate with the heart tissue, particularly the trabeculae found in the ventricles and the right atrial appendage, to maintain the electrode tip in position.
17 Claims, 13 Drawing Figures PATENTEU 2975 3.902501 SHEET 1 UP 2 1 ENDOCARDIAL ELECTRODE BACKGROUND OF, THE INVENTION Electrical stimulation of heart action is well-known and has been employed to counter a variety of heart dysfunctions. Dependent upon the particular dysfunction, optimal placement of the electrical Contact point or points may vary. However, optimal electrode placement has often been sacrificed to other considerations such as minimization of the surgical risk and reliability of the electrode securement. To date, the greatest number of electrodes have been ventricular electrodes with the transvenous-endocardial approach coming into the fore in recent years.
The advantages of a reliable electrical contact with the atrium are well-known. Such a contact would allow atrial pacing or atrial synchronized pacing thereby preserving the contribution of the atrial contraction in'the overall cardiac output. Additionally, an atrial contact would be advantageously employed for arrhythmia management and other purposes which may not be accomplished through ventricular electrical stimulation.
.For reasons well-known to those skilled in the art, the
greatest advantages can be obtained through an electrical contact with the right atrium, the right atrial appendage providing a suitable site.
An attempt to accomplish transvenous or endocardial atrial pacing is described in Smyth et. al. Permanent Transvenous Atrial Pacing, An Experimental and Clinical Study, The Annals of Thoracic Surgery, Volume II, No. 4, Apr. 19, 1971, pages 360-70. Here, a J-shaped catheter with a flange near the tip was inserted into the right atrial appendage through a transvenous approach. The catheter was straightened by the insertion of a stylet. When the stylet was with drawn, the catheter assumed itspreformed J shape for placement of the electrode tip in the atrial appendage. There was no attempt to artificially secure the electrode tip in position, the atrial trabeculae and shape of the catheter being relied upon to maintain it in location until the heart tissue itself enveloped and fixed the tip. The metal parts of the catheter may be radiopaque to facilitate placement by viewing through fluoroscopy.
A sensing atrial endocardial electrode is described in Portsmann et. al., P Wave Synchronous Pacing Using Anchored Atrial Electrode Implanted Without Thoractomy", The American Journal of Cardiology, Volume 30, July 1 l, 1972, pages 74-76. A .I-shaped applicator catheter was used to direct the electrode tip into the right atrial appendage. The electrode however, had two fine wire hooks positioned at its tip each ending in a relieving loop. The hooks were held back by the applicator catheter to spring out and anchor the electrode in the trabeculae of the right atrial appendage whenthe electrode tip left the end of the applicator catheter.
In the applicator catheter technique described above, the applicator catheter was radiopaque so that it could be viewed as it was inserted into the right atrial appendage. It is imperative with the double hook tip that the electrode be properly placed before the hooks are released. The placement was checked not only through fluoroscopy but also by extending the tip slightly beyond the end of the applicator catheter to take a threshold measurement. The tip had-to be extended sufficiently to take an accurate measurementwhile still I retaining the hooks within the applicator catheter. Be-
SUMMARY OF THE PRESENT INVENTION The present invention provides an electrode uniquely adapted for use as an atrial endocardial electrode. The electrode may be positioned in the right atrial appendage through the use of a .I-shaped catheter known to the prior art. Alternatively, a J-shaped stylet may be employed which is held in a straightened position by thewalls of the vein used to approach the heart, the stylet assuming its J-shape upon entry into the right atrium. A plurality of pliant non-conductive tines are provided at the tip of the electrode to cooperate with the heart tissue, particularly the trabeculae found in the right atrial appendage, to maintain the electrode tip in electrical contact with the heart tissue while allowing a removal of the electrode should that prove necessary. Provision is also made for holding the tines against the electrode body during insertion while allowing their release when the tip is in position and after a test threshold measurement. Although the electrode is discussed inthe context of the right atrial appendage, it is suitable for use in any portion of the heart having the requisite cooperating tissue and may be employed as either a sensing or pacing electrode.
BRIEF DESCRIPTION OF THE DRAWINGS FIG. I shows a preferred embodiment of the present invention.
FIG. 2 shows a cross section of the preferred embodiment of FIG. Itaken along the line 22 in FIG. 1.
FIG. 3 shows a cross section of another preferred embodiment taken-along the line 2-2 in FIG. 1.
FIG. 4 illustrates apparatus which may be used with the preferred embodiment of FIG. I.
FIG. 5 shows acomponentof another preferred embodiment of the present invention.
FIG. 6 shows'a preferred embodiment of the present invention whichutilizes the component of FIG. 5, the tines being in a restrained position.
FIG. 7 shows the embodiment. of FIG. 6 with the tines unrestrained.
FIG. '8 shows another preferred embodiment of the present invention.
FIG. 9 shows still another preferred embodiment of the present invention.
FIG. 10 shows a further preferred embodiment of the present invention.
FIG. 11 shows a portion of the preferred embodiment of FIG.- 10.
FIG. 12 shows a portion of the preferred embodiment of FIG. 10.
FIG. 13 shows anadditional preferred embodiment of the present invention.
DETAILED. DESCRIPTION GFTHE DRAWINGS tive tip 11 and a plurality of tines 12 extending at an acute angle from the body member from a position adjacent the tip 11. The electrically conductive tip 11 may be of any material suitable for the environment; platinum-iridium, for example. The tines 12 are ofa pliant material which is generally inert to body fluids; silicone rubber or polyurethane, for example. The tines 12 may be attached to the body member 10 in any convenient manner. For example, the tines may extend from, and be unitary with, a disc 13 which disc is held in position between the body member 10 and tip 11. Alternatively, the member 13 may be in the form of a ring which lies over either the body member 10 or tip 11 and is adhered thereto in any convenient manner. The tines 12 may take any angle with the body member 10, their purpose being to cooperate with the body tissue, particularly the trabeculae of the right atrial appendage, to maintain the tip 11 in electrical contact with the body tissue. It can be seen that an acute angle formed by the tines l2 and the body member 10 will have the greatest tendency to push against and become involved with the cooperating trabeculae and maintain the tip 11 in electrical contact. It has been found, that an angle of approximately 45 maintains the necessary electrical contact is a very efficient manner. Further, any number of tines may be used; three having proven to be adequate in most situations.
Referring now to FIG. 2 wherein there is shown a cross section of a preferred embodiment of the body member 10 of FIG. 1 taken along the line 22. In this embodiment, an elongated electrical conductor 15 runs substantially the length of the body member 10 and makes electrical contact with the tip 11. The conductor 15 is encased within a catheter 16 of a material which is generally inert to body fluids.
It is desirable that the catheter conductor combination be made as flexible as possible. To accomplish this purpose while providing the necessary rigidity for insertion of the electrode, a stylet lumen 19 is provided, the stylet being within the lumen 19 during insertion of the electrode and being withdrawn after placement is accomplished. In a preferred embodiment, the stylet which is placed into the lumen 19 has a J configuration similar to that of the prior art applicator catheters. During insertion, the stylet is maintained in a straightened configuration by the walls of the vessel through which insertion is accomplished. When the electrode tip reaches the atrium, the stylet assumes its J configuration thereby allowing an easy insertion into the appendage. When the placement of the electrode tip is accomplished, the stylet is withdrawn. In this embodiment, the electrical conductor can be of any known type, one preferred form being a multistrand wire of platinum, for example, commonly referred to as tinsel wire. I
A second preferred form for the body member 10 is illustrated in FIG. 3. Here, the electrical conductor is a coiled member 17 which again runs substantially the length of the body member 10. The coil 17 is encased in a catheter 16 substantially identical to that shown in FIG. 2. The central portion of the coil 17 is left at least partially void to forma lumen 18 for the insertion of a stylet, the stylet serving essentially the same function in this embodiment as in the embodiment of FIG. 2. Further, in both the embodiments of FIG. 2 and FIG. 3, the lumens l9 and 18 may be lined with Teflon or any other appropriate material to facilitate the insertion and removal of the stylet.
Referring now to FIG. 4, there is again shown an electrode body portion 10 this time at the end farthest from the tip 11. In some applications, a pin type connection to an external stimulator or sensing device is desired. For this purpose, the body portion 10 commonly has an enlarged segment 20 from which extends the connecting pin 21. If it is desired to insert the electrode through the use of the J-shaped applicator catheter known to the prior art, the catheter must be made suffieiently large to slide back over the enlarged portion 20 or, alternatively, some other system for removal of the catheter must be provided. Here, the applicator catheter is shown at 22 of a size not sufficiently large to be withdrawn over the enlarged portion 20. A cutting tool 23 is shown adjacent the enlarged portion 20 and extending forward of the enlarged portion with a wedge 24 and a knife blade 25. The cutting tool 23 may be separate from the electrode body 10 or may be attached thereto in any convenient manner. In operation, the wedge portion 24 slips under the edge of the applicator catheter 22 and, as the applicator catheter 22 is drawn toward the cutting tool 23, the wedge will direct the catheter 22 into contact with the knife blade which will then cut and separate it thus allowing the removal of the applicator catheter over the enlarged portion 20.
The electrode shown in the embodiment of FIG. 1 may be successfully inserted into the right atrial appendage through a transvenous approach using the stylet technique of either FIGS. 2 or 3 or the .I-shaped applicator catheter technique. In the applicator catheter technique, the tines 12 are not exposed during insertion. In the stylet technique of either FIGS. 2 or 3, however, the tines are non-restrained or extended during the entire operation. Although the electrode may be successfully positioned in this condition, it is found that the blood flow tends to draw the electrode tip into the ventrical. For this reason, some means of restraining the tines during insertion is desirable.
Referring now to FIG. 5, there is shown a balloon catheter similar to the balloon catheters used for other applications. Specifically, the catheter body 10 has a portion 30 which is inflatable from an end 32. The inflation is accomplished through a lumen similar to the stylet lumen 19 and 18 of FIGS. 2 and 3 respectively. Indeed, the inflation can be accomplished through the stylet lumens 19 and 18, the lumens being made sufficiently large to accomodate the stylet while allowing a passage for air to inflate the balloon. The ballooning feature of the electrode body 10 may be accomplished in any known manner. Referring now to FIG. 6, there is shown an electrode having a body 10 and a tip 11 as described with reference to the embodiment of FIG. 1. The body 10 is composed of a balloon catheter as illustrated in FIG. 5 with the ballooning or inflatable part lying adjacent the tip 1 l. A hold down shroud 31 is positioned near the tip 11 and is adapted to receive at least the ends of the tines 12 to restrain them in a position wherein they overlie the inflatable portion 30 of the electrode body 10. With the tines in this restrained position, a stylet may be inserted into a lumen such as that illustrated in FIGS. 2 or 3 and the electrode inserted through a transvenous approach without any interference from the extended tines. When the electrode tip is believed to be in an acceptable position as viewed by fluoroscopy, a test measurement can be made. If the site of the electrode tip proves satisfactory, the balloon 30 can be inflated from the end of the electrode still outside the body causing the tines to withdraw from the shroud 31 and extend into their normal unrestrained position as illustrated in FIG. 7. With the tines freed from the shroud 31 the inflating pressure can be released and the balloon 30 will deflate to a normal configuration. The shroud 31 may take any shape which can accept at least the end portions of the tines 12. A ring which is attached to the body by spaced tethers is an example of an obvious modification of the shroud 31.
An alternative shroud to the shroud 31 of FIG. 7 is illustrated at 35 in FIG. 8. This shroud 35 again is adapted to accept at least the end portion of the tines 12 to restrain them in a position wherein they overlie the body of the electrode 10. A line 36 is attached to the shroud 35 at 37, and when the tip is properly positioned, a force on the line 36 will cause the shroud 35 to withdraw thus freeing the tines 12 to assume their extended unrestrained position. A similar approach is illustrated in FIG. 9 wherein a stylet 40 is shown having a coiled portion 41 which coiled portion is wrapped around the tines causing them to lie flat against the body member 10. Again, when the tip 11 is properly positioned, the stylet will be withdrawn thereby freeing the tines for interaction with the trabeculae of the right atrial appendage, for example.
Referring now to FIG. 10, there is shown another preferred embodiment of the present invention. Specifically, there is shown an electrode body 10 composed of a connecting portion 50, a central portion 51 and an end portion 52 which lies between the tip 11 and the shroud 53. The cross section of the central portion 51 may be as illustrated in FIG. 3. That is, the electrical conductor is a coiled member 17 having a void lumen forming central portion 18, the conductor extending from the tip 11 back to the connecting portion 50. The connecting portion 50 is similar to that illustrated in FIG. 4 with the connecting pin 54 making an electrical contact with the electrical conductor 17 and having a lumen coincident with the lumen 18 of the conductor 17. With this configuration, it is possible to insert a stylet 55 through the end of the connecting pin 54 to abut the tip 11. Inasmuch as the electrical conductor is a coiled member it can be stretched or elongated by applying a pressure against the tip 11 with the stylet 55. Since the electrical conductor is typically uniform throughout its length, the location at which the elec trode body will give or elongate can be controlled to the durometer or diameter of the electrode body, or both. For reasons to be explained more fully below, it is desired that the portion 52 of the electrode body 10 give before the central portion 51 or the connecting portion 50. Therefore, the portion 52 is illustrated as having a smaller diameter than either the central portion 51 or the connecting portion 50. Alternatively, the material comprising the portion 52 may have a lower durometer than either of the other portions of the electrode body 10 or it may have a lower durometer and diameter, as desired.
FIG. 11 illustrates the embodiment of FIG. 10 with the tines 12 having at least their ends restrained by the shroud 53 in a manner substantially identical to that illustrated in FIG. 6. With the tines in their restrained position, the electrode can be inserted and positioned and, when a proper positioning is obtained as described above, the stylet is forced against the tip 11 causing the portion 52 to stretch as illustrated in FIG. 12 thereby releasing the tines 12 from the shroud 53. With the tines released, the stylet is removed thereby allowing the portion 52 to assume its normal shape as illustrated in phantom at FIG. 12.
As stated with regard to the shroud 31 of FIGS. 6 and 7, the shroud 53 of FIGS. 10-12 may take the form of a ring connected to the electrode body by means of a plurality of tethers. Such a ring shroud is illustrated at in FIG. 13. As can be seen, the shroud 60 has a ring or a doughnut configuration and is held in place by means of tethers 61 which perform essentially as the spokes of a wheel, the tethers 61 being positioned so as not to interfere with the restraining and release of the tines 12.
From the above, it can be seen that the present invention provides a new medical electrode uniquely adapted for use as an endocardial electrode. The electrode provides means for cooperating with the heart tissue, particularly the trabeculae of the ventricles and right atrial appendage, to provide an artificial fixation until such time as a natural fixation has occurred. The tines are of a pliant material which is sufficiently rigid to accomplish their purpose without having the snapping action and sharp points attendant in the prior art devices. Further, the present invention provides a system for positioning the electrode and making any necessary test measurements prior to its being finally posi tioned, the position of the tip with regard to the inserting devices being much less critical in the present invention than in the prior art devices because the tines may be selectively released independently of the insertion device.
Obviously, many modifications and variations of the present invention are possible in light of the above teaching. An example of such a modification would be to make the body member 10 or the tines 12, or both, radiopaque to facilitate the positioning by observation of the electrode through Xray., fluoroscopy, etc. We have found that this can be accomplished through impregnation with carbon, barium sulfate or Tantalum. Of course, any suitable substance and method will be acceptable for this purpose. It is therefore to be understood that, within the scope of the appended claims, the invention may be practiced otherwise than as specifically described.
What is claimed is:
1. In an endocardial lead of the type having an electrical conductor encased in a material which is generally inert to body fluids, the conductor terminating at an exposed electrically conductive electrode tip, the improvement which comprises:
nonconducting tine means extending from said encasing material and away from said tip from a location adjacent said tip for cooperating with heart tissue, to hold the tip in position, said tine means forming a generally acute angle with said encasing material and being entirely of a pliant material having sufficient rigidity to maintain said angle when said tine means are unrestrained, but sufficiently pliant to prevent penetration of said heart tissue, said pliant material being generally inert to body fluids.
2. The lead of claim 1 wherein the improvement fur ther comprises means external to said encasing mate- 7 rial for releasably restraining said tinc means in a position overlying said encasing material.
3. The lead of claim 2 wherein said restraining means comprises shroud means for accepting at least the end portion of said tine means.
4. The lead of claim 3 wherein said restraining means further comprise means cooperating with said shroud means for effecting the release of said tine means at a point spaced from said shroud means.
5. The lead of claim 3 wherein the improvement further comprises:
inflatable means underlying said tine means when said tine means are in said restrained position; and means spaced from said inflatable means for selectively inflating said inflatable means.
6. The lead of claim 4 wherein said tine means are non-metallic.
7. An endocardial lead which comprises:
elongated electrically conductive means;
flexible catheter means surrounding said electrically conductive means and having a lumen substantially parallel to and coextensive with said electrically conductive means;
electrically conductive tip means at one end of said catheter means and electrically connected to said electrically conductive means; and
nonconducting tine means extending from said catheter means and away from said tip from a point adjacent said tip means for cooperation with heart tissue, to hold the tip in position, said tine means forming a generally acute angle with said catheter means and being entirely of a pliant material having sufficient rigidity to maintain said angle when said tine means are unrestrained, but sufficiently pliant to prevent penetration of said heart tissue, said pliant material being generally inert to body fluids.
8. The lead of claim 7 further comprising means for releasable restraining said tines in a position wherein they overlie said catheter means.
9. The lead of claim 8 wherein said restraining means comprises shroud means for accepting at least the end portion of said tine means. 7
10. The lead of claim 9 wherein said restraining means further comprises means cooperating with said shroud means for effecting the release of said tine means at a point spaced from said shroud means.
1 l. The lead of claim 9 wherein said catheter means comprises a balloon catheter, the balloon underlying the tines when the tines are in the restrained position.
12. The lead of claim 11 wherein said elongated electrically conductive means comprises a coiled electrical conductor having a void central portion, said lumen coinciding with said void central portion.
13. The lead of claim 11 wherein said elongated electrically conductive means is positioned substantially at the center of the cross section of said catheter means and said lumen lies off the center of said cross section.
14. In a medical lead of the type in which an electrical conductor is positioned within a catheter and terminates at an exposed electrically conductive electrode tip, the improvement which comprises:
nonconducting tine means including a plurality of tines each extending from said catheter and away from said tip from a point adjacent said tip and forming an acute angle with said catheter for cooperating with heart tissue to hold the tip in position, said tine means being entirely of a pliant material having sufficient rigidity to maintain said angle when said tine means are unrestrained, but sufficiently pliant to prevent penetration of said heart tissue; means for releasably restraining said tine means in a position wherein said tine means overlie said catheter; and I means underlying said tine means when said tine means are in said restrained position and inflatable from a point spaced from said restraining means for releasing said tine means from said restraining means upon inflation.
15. The medical lead of-claim 14 wherein the angle formed by said tine means and said catheter is approximately 45.
16. The medical lead of claim 14 wherein said pliant tine means material comprises a material which is relatively inert to body fluids, at least a portion of said material being radiopaque.
17. The medical lead of claim 16 wherein the radiopaque material portion is a material treated with a material selected from the group consisting of carbon, barium sulfate or Tantalum.
|Brevet cité||Date de dépôt||Date de publication||Déposant||Titre|
|US2854983 *||31 oct. 1957||7 oct. 1958||Arnold M Baskin||Inflatable catheter|
|US3348548 *||26 avr. 1965||24 oct. 1967||Chardack William M||Implantable electrode with stiffening stylet|
|US3397699 *||5 mai 1966||20 août 1968||Gerald C. Kohl||Retaining catheter having resiliently biased wing flanges|
|US3516410 *||3 janv. 1968||23 juin 1970||Hakim Salomon||Cerebro-ventricular catheter|
|US3568659 *||24 sept. 1968||9 mars 1971||Karnegis James N||Disposable percutaneous intracardiac pump and method of pumping blood|
|US3608555 *||31 déc. 1968||28 sept. 1971||Chemplast Inc||Radio opaque and optically transparent tubing|
|US3717151 *||11 mars 1971||20 févr. 1973||R Collett||Flesh penetrating apparatus|
|US3719190 *||9 mars 1971||6 mars 1973||Avery Lab Inc||Heart stimulation electrode with a conical positioning parachute|
|US3815608 *||10 mars 1972||11 juin 1974||East West Med Prod||Retaining catheter|
|US3835864 *||21 sept. 1970||17 sept. 1974||Rasor Ass Inc||Intra-cardiac stimulator|
|Brevet citant||Date de dépôt||Date de publication||Déposant||Titre|
|US4007732 *||2 sept. 1975||15 févr. 1977||Robert Carl Kvavle||Method for location and removal of soft tissue in human biopsy operations|
|US4030508 *||4 févr. 1976||21 juin 1977||Vitatron Medical B.V.||Low output electrode for cardiac pacing|
|US4033357 *||17 févr. 1976||5 juil. 1977||Medtronic, Inc.||Non-fibrosing cardiac electrode|
|US4106512 *||16 déc. 1976||15 août 1978||Medtronic, Inc.||Transvenously implantable lead|
|US4135518 *||21 mai 1976||23 janv. 1979||Medtronic, Inc.||Body implantable lead and electrode|
|US4136703 *||9 mars 1978||30 janv. 1979||Vitatron Medical B.V.||Atrial lead and method of inserting same|
|US4141365 *||24 févr. 1977||27 févr. 1979||The Johns Hopkins University||Epidural lead electrode and insertion needle|
|US4144890 *||19 déc. 1976||20 mars 1979||Cordis Corporation||Contact device for muscle stimulation|
|US4166469 *||13 déc. 1977||4 sept. 1979||Littleford Philip O||Apparatus and method for inserting an electrode|
|US4257428 *||16 oct. 1978||24 mars 1981||Barton Steven A||Retractable stimulation electrode apparatus and method|
|US4269198 *||26 déc. 1979||26 mai 1981||Medtronic, Inc.||Body implantable lead|
|US4289144 *||10 janv. 1980||15 sept. 1981||Medtronic, Inc.||A-V Sidearm lead|
|US4402328 *||28 avr. 1981||6 sept. 1983||Telectronics Pty. Limited||Crista terminalis atrial electrode lead|
|US4407303 *||9 avr. 1981||4 oct. 1983||Siemens Aktiengesellschaft||Endocardial electrode arrangement|
|US4465079 *||13 oct. 1982||14 août 1984||Medtronic, Inc.||Biomedical lead with fibrosis-inducing anchoring strand|
|US4467817 *||18 mai 1983||28 août 1984||Cordis Corporation||Small diameter lead with introducing assembly|
|US4473067 *||28 avr. 1982||25 sept. 1984||Peter Schiff||Introducer assembly for intra-aortic balloons and the like incorporating a sliding, blood-tight seal|
|US4475560 *||29 avr. 1982||9 oct. 1984||Cordis Corporation||Temporary pacing lead assembly|
|US4549557 *||1 nov. 1983||29 oct. 1985||Hakki A Hadi I||Pacemaker electrode|
|US4564023 *||28 mars 1983||14 janv. 1986||Cordis Corporation||Retention skirt for pacing electrode assembly|
|US4581019 *||22 avr. 1982||8 avr. 1986||Curelaru Johan||Device for introducing a catheter-cannula into a blood vessel|
|US4590949 *||1 nov. 1984||27 mai 1986||Cordis Corporation||Neural stimulating lead with stabilizing mechanism and method for using same|
|US4631059 *||26 mars 1985||23 déc. 1986||Datascope Corp.||Sheath remover|
|US4641656 *||20 juin 1985||10 févr. 1987||Medtronic, Inc.||Cardioversion and defibrillation lead method|
|US4641664 *||15 avr. 1985||10 févr. 1987||Siemens Aktiengesellschaft||Endocardial electrode arrangement|
|US4669488 *||7 oct. 1985||2 juin 1987||Cordis Corporation||Retention skirt for pacing electrode assembly|
|US4687469 *||31 mai 1985||18 août 1987||Peter Osypka||Device for slitting introducers for pacemaker electrodes|
|US4722353 *||16 sept. 1985||2 févr. 1988||Intermedics, Inc.||Stabilizer for implantable electrode|
|US4730389 *||15 août 1986||15 mars 1988||Medtronic, Inc.||Method for fabrication of an implantable hermetic transparent container|
|US4791935 *||15 août 1986||20 déc. 1988||Medtronic, Inc.||Oxygen sensing pacemaker|
|US4807629 *||19 nov. 1987||28 févr. 1989||Medtronic, Inc.||Oxygen sensing pacemaker|
|US4841971 *||29 mars 1988||27 juin 1989||Cordis Leads, Inc.||Endocardial lead with projections having saw tooth formation|
|US4892102 *||26 sept. 1986||9 janv. 1990||Astrinsky Eliezer A||Cardiac pacing and/or sensing lead and method of use|
|US4913147 *||23 sept. 1987||3 avr. 1990||Siemens Aktiengesellschaft||Heart pacemaker system with shape-memory metal components|
|US4913164 *||27 sept. 1988||3 avr. 1990||Intermedics, Inc.||Extensible passive fixation mechanism for lead assembly of an implantable cardiac stimulator|
|US4945922 *||13 mars 1989||7 août 1990||Vitatron Medical B.V.||Pacing lead|
|US4997424 *||5 avr. 1989||5 mars 1991||Medamicus, Inc.||Catheter introducer and introducer slitter|
|US5111828 *||18 sept. 1990||12 mai 1992||Peb Biopsy Corporation||Device for percutaneous excisional breast biopsy|
|US5179962 *||20 juin 1991||19 janv. 1993||Possis Medical, Inc.||Cardiac lead with retractible fixators|
|US5197484 *||8 mai 1992||30 mars 1993||Peb Biopsy Corporation||Method and device for precutaneous excisional breast biopsy|
|US5207226 *||25 janv. 1991||4 mai 1993||Regents Of The University Of Minnesota||Device and method for measurement of blood flow|
|US5231996 *||28 janv. 1992||3 août 1993||Medtronic, Inc.||Removable endocardial lead|
|US5238007 *||12 déc. 1991||24 août 1993||Vitatron Medical B.V.||Pacing lead with improved anchor mechanism|
|US5300107 *||22 oct. 1992||5 avr. 1994||Medtronic, Inc.||Universal tined myocardial pacing lead|
|US5344439 *||30 oct. 1992||6 sept. 1994||Medtronic, Inc.||Catheter with retractable anchor mechanism|
|US5353804 *||17 mars 1993||11 oct. 1994||Peb Biopsy Corporation||Method and device for percutaneous exisional breast biopsy|
|US5354327 *||7 avr. 1993||11 oct. 1994||Medtronic, Inc.||Conductor coil with specific ratio of torque to bending stiffness|
|US5360441 *||30 oct. 1992||1 nov. 1994||Medtronic, Inc.||Lead with stylet capture member|
|US5364337 *||14 avr. 1993||15 nov. 1994||Medtronic, Inc.||Muscle powered cardiac assist system|
|US5383922 *||15 mars 1993||24 janv. 1995||Medtronic, Inc.||RF lead fixation and implantable lead|
|US5476500 *||20 déc. 1993||19 déc. 1995||Ventritex, Inc.||Endocardial lead system with defibrillation electrode fixation|
|US5480421 *||5 août 1994||2 janv. 1996||Medtronic, Inc.||Lead with stylet capture member|
|US5545206 *||22 déc. 1994||13 août 1996||Ventritex, Inc.||Low profile lead with automatic tine activation|
|US5571162 *||7 juin 1995||5 nov. 1996||Intermedics, Inc.||Transvenous defibrillation lead with side hooks|
|US5683447 *||19 déc. 1995||4 nov. 1997||Ventritex, Inc.||Lead with septal defibrillation and pacing electrodes|
|US5693081 *||11 oct. 1995||2 déc. 1997||Pacesetter, Inc.||Endocardial lead system with defibrillation electrode fixation|
|US5713945 *||13 juin 1996||3 févr. 1998||Pacesetter, Inc.||Implantable lead modified to reduce tissue ingrowth|
|US5755761 *||26 avr. 1996||26 mai 1998||Pharmatarget, Inc.||Atrial pacing catheter and method having multiple electrodes in the right atrium and coronary sinus|
|US5755767 *||2 août 1996||26 mai 1998||Pacesetter, Inc.||Anti-dislodgment and anti-perforation distal tip design for transvenous lead|
|US5759202 *||28 avr. 1997||2 juin 1998||Sulzer Intermedics Inc.||Endocardial lead with lateral active fixation|
|US5769881 *||22 mai 1997||23 juin 1998||Sulzer Intermedics Inc.||Endocardial lead with multiple branches|
|US5807399 *||23 oct. 1996||15 sept. 1998||Medtronic, Inc.||Method for removal of chronically implanted leads and leads optimized for use therewith|
|US5871532 *||22 mai 1997||16 févr. 1999||Sulzer Intermedics Inc.||Epicardial lead for minimally invasive implantation|
|US5897585 *||18 déc. 1997||27 avr. 1999||Medtronic, Inc.||Stretchable pacing lead|
|US5931864 *||20 févr. 1998||3 août 1999||Cardiac Pacemakers, Inc.||Coronary venous lead having fixation mechanism|
|US5971967 *||19 août 1997||26 oct. 1999||Abbeymoor Medical, Inc.||Urethral device with anchoring system|
|US6026567 *||11 mai 1995||22 févr. 2000||Medtronic, Inc.||Medical lead with stranded conductors|
|US6173206||7 mai 1999||9 janv. 2001||Ethicon, Inc.||Temporary pacing wire anchor|
|US6178356||26 mars 1999||23 janv. 2001||Cardiac Pacemakers, Inc.||Coronary venous lead having fixation mechanism|
|US6181973||7 juil. 1999||30 janv. 2001||Claudio Ceron||Anchoring structure for implantable electrodes|
|US6183505||11 mars 1999||6 févr. 2001||Medtronic Ave, Inc.||Method of stent retention to a delivery catheter balloon-braided retainers|
|US6221060||4 oct. 1999||24 avr. 2001||Abbeymoor Medical, Inc.||Urethral device with anchoring system|
|US6258060||30 juin 1999||10 juil. 2001||Abbeymoon Medical, Inc.||Urethral apparatus with position indicator and methods of use thereof|
|US6315778||10 sept. 1999||13 nov. 2001||C. R. Bard, Inc.||Apparatus for creating a continuous annular lesion|
|US6331189||18 oct. 1999||18 déc. 2001||Medtronic, Inc.||Flexible medical stent|
|US6334871||3 sept. 1996||1 janv. 2002||Medtronic, Inc.||Radiopaque stent markers|
|US6402777||22 août 2000||11 juin 2002||Medtronic, Inc.||Radiopaque stent markers|
|US6405091||20 juil. 1999||11 juin 2002||Pacesetter, Inc.||Lead assembly with masked microdisk tip electrode and monolithic controlled release device|
|US6489562||1 avr. 1997||3 déc. 2002||Medtronic, Inc||Medical electrical lead having variable stiffness tip-ring spacer|
|US6516230||26 avr. 2000||4 févr. 2003||Medtronic, Inc.||Medical electrical lead with fiber core|
|US6730116||16 avr. 1999||4 mai 2004||Medtronic, Inc.||Medical device for intraluminal endovascular stenting|
|US6792318||13 juin 2002||14 sept. 2004||Pacesetter, Inc.||Technique for fixating a lead|
|US6805699 *||8 mai 2003||19 oct. 2004||Peter Shimm||Laparoscopic specimen retrieval shoehorn|
|US6814746||1 nov. 2002||9 nov. 2004||Ev3 Peripheral, Inc.||Implant delivery system with marker interlock|
|US6837848||15 janv. 2003||4 janv. 2005||Medtronic, Inc.||Methods and apparatus for accessing and stabilizing an area of the heart|
|US6887255 *||19 avr. 2002||3 mai 2005||Peter Shimm||Laparoscopic specimen extraction port|
|US6918908||17 juil. 2003||19 juil. 2005||Medtronic, Inc.||Methods and apparatus for accessing and stabilizing an area of the heart|
|US6918928||28 févr. 2003||19 juil. 2005||Medtronic, Inc.||Medical device for intraluminal endovascular stenting|
|US6999819||9 nov. 2001||14 févr. 2006||Medtronic, Inc.||Implantable medical electrical stimulation lead fixation method and apparatus|
|US7029460||15 févr. 2002||18 avr. 2006||Medtronic, Inc.||Slitting tool|
|US7092764||30 avr. 2002||15 août 2006||Medtronic, Inc.||Helix rotation by traction|
|US7276057||30 avr. 2004||2 oct. 2007||Medtronic, Inc.||Method, system and device for treating disorders of the pelvic floor by drug delivery to the pudendal and sacral nerves|
|US7277762 *||25 oct. 2002||2 oct. 2007||Belden Elisabeth L||Radiopague marking of lead electrode zone in a continuous conductor construction|
|US7328068||26 nov. 2003||5 févr. 2008||Medtronic, Inc.||Method, system and device for treating disorders of the pelvic floor by means of electrical stimulation of the pudendal and associated nerves, and the optional delivery of drugs in association therewith|
|US7328069||30 avr. 2004||5 févr. 2008||Medtronic, Inc.||Method, system and device for treating disorders of the pelvic floor by electrical stimulation of and the delivery of drugs to the left and right pudendal nerves|
|US7330764||28 avr. 2004||12 févr. 2008||Medtronic, Inc.||Implantable medical electrical stimulation lead fixation method and apparatus|
|US7338481||14 févr. 2003||4 mars 2008||Medtronic, Inc.||Slitting tool|
|US7349742||23 déc. 2003||25 mars 2008||Cardiac Pacemakers, Inc.||Expandable fixation elements for subcutaneous electrodes|
|US7369894||30 avr. 2004||6 mai 2008||Medtronic, Inc.||Method, system and device for treating disorders of the pelvic floor by electrical stimulation of the sacral and/or pudendal nerves|
|US7418292||8 avr. 2004||26 août 2008||Medtronic, Inc.||Device and method for attenuating an immune response|
|US7427280||30 avr. 2004||23 sept. 2008||Medtronic, Inc.||Method, system and device for treating disorders of the pelvic floor by delivering drugs to various nerves or tissues|
|US7473224||22 mai 2002||6 janv. 2009||Ethicon Endo-Surgery, Inc.||Deployable ultrasound medical transducers|
|US7473250||21 mai 2004||6 janv. 2009||Ethicon Endo-Surgery, Inc.||Ultrasound medical system and method|
|US7493175||18 déc. 2003||17 févr. 2009||Cardiac Pacemakers, Inc.||Subcutaneous lead with tined fixation|
|US7494467||16 avr. 2004||24 févr. 2009||Ethicon Endo-Surgery, Inc.||Medical system having multiple ultrasound transducers or an ultrasound transducer and an RF electrode|
|US7499758||18 déc. 2003||3 mars 2009||Cardiac Pacemakers, Inc.||Helical fixation elements for subcutaneous electrodes|
|US7610106||6 nov. 2003||27 oct. 2009||Yacoubian Vahe S||Epicardial heartwire with chest tube|
|US7615057||12 févr. 2004||10 nov. 2009||Cardiac Pacemakers, Inc.||Notched cutter for guide catheter removal from lead|
|US7620454||19 mai 2003||17 nov. 2009||Medtronic, Inc.||Gastro-electric stimulation for reducing the acidity of gastric secretions or reducing the amounts thereof|
|US7628780||30 nov. 2004||8 déc. 2009||Medtronic, Inc.||Devices and methods for interstitial injection of biologic agents into tissue|
|US7695436||21 mai 2004||13 avr. 2010||Ethicon Endo-Surgery, Inc.||Transmit apodization of an ultrasound transducer array|
|US7740623||23 juin 2005||22 juin 2010||Medtronic, Inc.||Devices and methods for interstitial injection of biologic agents into tissue|
|US7742818||19 mai 2003||22 juin 2010||Medtronic, Inc.||Gastro-electric stimulation for increasing the acidity of gastric secretions or increasing the amounts thereof|
|US7744562||10 oct. 2006||29 juin 2010||Medtronics, Inc.||Devices and methods for interstitial injection of biologic agents into tissue|
|US7761167||2 oct. 2006||20 juil. 2010||Medtronic Urinary Solutions, Inc.||Systems and methods for clinician control of stimulation systems|
|US7769442||29 août 2006||3 août 2010||Medtronic, Inc.||Device and method for inhibiting release of pro-inflammatory mediator|
|US7801624 *||16 janv. 2007||21 sept. 2010||Pacesetter, Inc.||Reduced perforation distal tip for an implantable cardiac electrotherapy lead|
|US7806839||14 juin 2004||5 oct. 2010||Ethicon Endo-Surgery, Inc.||System and method for ultrasound therapy using grating lobes|
|US7806892||22 mai 2002||5 oct. 2010||Ethicon Endo-Surgery, Inc.||Tissue-retaining system for ultrasound medical treatment|
|US7813809||10 juin 2005||12 oct. 2010||Medtronic, Inc.||Implantable pulse generator for providing functional and/or therapeutic stimulation of muscles and/or nerves and/or central nervous system tissue|
|US7840281||21 juil. 2006||23 nov. 2010||Boston Scientific Scimed, Inc.||Delivery of cardiac stimulation devices|
|US7846096||24 nov. 2003||7 déc. 2010||Ethicon Endo-Surgery, Inc.||Method for monitoring of medical treatment using pulse-echo ultrasound|
|US7848821||11 juil. 2006||7 déc. 2010||Pacesetter, Inc.||Apparatus and method for electrode insertion in heart tissue|
|US7848823||28 août 2006||7 déc. 2010||Boston Scientific Scimed, Inc.||Cardiac stimulation system|
|US7865250 *||30 nov. 2005||4 janv. 2011||Medtronic Urinary Solutions, Inc.||Methods for electrical stimulation of nerves in adipose tissue regions|
|US7881783 *||28 avr. 2006||1 févr. 2011||Medtronics, Inc.||Implantable medical electrical stimulation lead, such as a PNE lead, and method of use|
|US7883468||18 mai 2004||8 févr. 2011||Ethicon Endo-Surgery, Inc.||Medical system having an ultrasound source and an acoustic coupling medium|
|US7890191||28 févr. 2008||15 févr. 2011||Medtronic, Inc.||Implantable medical device system with fixation member|
|US7904179||28 févr. 2008||8 mars 2011||Medtronic, Inc.||Implantable medical device system with fixation member|
|US7912555||31 janv. 2008||22 mars 2011||Medtronic, Inc.||Implantable medical electrical stimulation lead fixation method and apparatus|
|US7925358||29 août 2007||12 avr. 2011||Medtronic, Inc.||Radiopaque marking of lead electrode zone in a continuous conductor construction|
|US7951095||20 mai 2004||31 mai 2011||Ethicon Endo-Surgery, Inc.||Ultrasound medical system|
|US8000805||30 oct. 2006||16 août 2011||Medtronic, Inc.||Implantable medical lead including tine markers|
|US8036756||13 févr. 2006||11 oct. 2011||Medtronics Inc||Implantable medical electrical stimulation lead fixation method and apparatus|
|US8050774||22 déc. 2005||1 nov. 2011||Boston Scientific Scimed, Inc.||Electrode apparatus, systems and methods|
|US8108054 *||4 févr. 2009||31 janv. 2012||Pacesetter, Inc.||Active fixation implantable medical lead configured to indicate via fluoroscopy embedment of helical anchor in cardiac tissue|
|US8165692||3 juil. 2007||24 avr. 2012||Medtronic Urinary Solutions, Inc.||Implantable pulse generator power management|
|US8185213||22 oct. 2010||22 mai 2012||Boston Scientific Scimed, Inc.||Delivery of cardiac stimulation devices|
|US8195304||12 oct. 2007||5 juin 2012||Medtronic Urinary Solutions, Inc.||Implantable systems and methods for acquisition and processing of electrical signals|
|US8204605||4 févr. 2009||19 juin 2012||Cardiac Pacemakers, Inc.||Multi-site atrial electrostimulation|
|US8273072||18 nov. 2009||25 sept. 2012||Medtronic, Inc.||Devices and methods for interstitial injection of biologic agents into tissue|
|US8290600||21 juil. 2006||16 oct. 2012||Boston Scientific Scimed, Inc.||Electrical stimulation of body tissue using interconnected electrode assemblies|
|US8332036||8 mars 2007||11 déc. 2012||Boston Scientific Scimed, Inc.||Leadless cardiac stimulation systems|
|US8340780 *||7 mai 2007||25 déc. 2012||Scimed Life Systems, Inc.||Leadless cardiac stimulation systems|
|US8388541||25 nov. 2008||5 mars 2013||C. R. Bard, Inc.||Integrated system for intravascular placement of a catheter|
|US8388546||5 mars 2013||Bard Access Systems, Inc.||Method of locating the tip of a central venous catheter|
|US8437833||7 oct. 2009||7 mai 2013||Bard Access Systems, Inc.||Percutaneous magnetic gastrostomy|
|US8467875||28 mars 2007||18 juin 2013||Medtronic, Inc.||Stimulation of dorsal genital nerves to treat urologic dysfunctions|
|US8478382||11 févr. 2009||2 juil. 2013||C. R. Bard, Inc.||Systems and methods for positioning a catheter|
|US8478408||8 mars 2007||2 juil. 2013||Boston Scientific Scimed Inc.||Leadless cardiac stimulation systems|
|US8489189 *||29 oct. 2004||16 juil. 2013||Medtronic, Inc.||Expandable fixation mechanism|
|US8512256||9 sept. 2010||20 août 2013||Bard Access Systems, Inc.||Method of locating the tip of a central venous catheter|
|US8626314||14 juil. 2011||7 janv. 2014||Medtronic, Inc.||Implantable medical lead including a plurality of tine elements|
|US8644934||13 sept. 2007||4 févr. 2014||Boston Scientific Scimed Inc.||Cardiac stimulation using leadless electrode assemblies|
|US8644953||10 août 2012||4 févr. 2014||Greatbatch Ltd.||Lead with braided reinforcement|
|US8694128||25 janv. 2008||8 avr. 2014||Medtronic, Inc.||Medical electrical lead|
|US8696729||31 mars 2008||15 avr. 2014||Covidien Lp||Implant delivery system with marker interlock|
|US8706252||1 juil. 2010||22 avr. 2014||Medtronic, Inc.||Systems and methods for clinician control of stimulation system|
|US8715295||18 juil. 2012||6 mai 2014||Interrad Medical, Inc.||Temporary retention device|
|US8721558 *||24 juil. 2009||13 mai 2014||Biotronik Crm Patent Ag||Device for determining the flow rate of a blood flow, and cardiovascular assist device|
|US8738147||29 janv. 2009||27 mai 2014||Cardiac Pacemakers, Inc.||Wireless tissue electrostimulation|
|US8771232 *||17 août 2011||8 juil. 2014||Interrad Medical, Inc.||Anchor device and method|
|US8774907||9 janv. 2013||8 juil. 2014||Bard Access Systems, Inc.||Method of locating the tip of a central venous catheter|
|US8781555||2 mars 2010||15 juil. 2014||C. R. Bard, Inc.||System for placement of a catheter including a signal-generating stylet|
|US8784336||23 août 2006||22 juil. 2014||C. R. Bard, Inc.||Stylet apparatuses and methods of manufacture|
|US8801693||27 oct. 2011||12 août 2014||C. R. Bard, Inc.||Bioimpedance-assisted placement of a medical device|
|US8849382||10 sept. 2009||30 sept. 2014||C. R. Bard, Inc.||Apparatus and display methods relating to intravascular placement of a catheter|
|US8858455||16 août 2013||14 oct. 2014||Bard Access Systems, Inc.||Method of locating the tip of a central venous catheter|
|US8897878 *||6 mai 2010||25 nov. 2014||Cardiac Pacemakers, Inc.||Method and apparatus for gastrointestinal stimulation via the lymphatic system|
|US8918193||15 août 2007||23 déc. 2014||Vahe S. Yacoubian||Heart wire|
|US8971994||8 avr. 2013||3 mars 2015||C. R. Bard, Inc.||Systems and methods for positioning a catheter|
|US8974434||9 nov. 2012||10 mars 2015||Interrad Medical, Inc.||System for anchoring medical devices|
|US8986257||15 nov. 2012||24 mars 2015||Interrad Medical, Inc.||System for anchoring medical devices|
|US9005144||18 déc. 2012||14 avr. 2015||Michael H. Slayton||Tissue-retaining systems for ultrasound medical treatment|
|US9056187||1 nov. 2013||16 juin 2015||Interrad Medical, Inc.||Anchor systems and methods|
|US9072911||27 juin 2013||7 juil. 2015||Boston Scientific Scimed, Inc.||Leadless cardiac stimulation systems|
|US9125578||2 févr. 2011||8 sept. 2015||Bard Access Systems, Inc.||Apparatus and method for catheter navigation and tip location|
|US9132287||17 août 2010||15 sept. 2015||T. Douglas Mast||System and method for ultrasound treatment using grating lobes|
|US20020177888 *||30 avr. 2002||28 nov. 2002||Medtronic, Inc.||Helix rotation by traction|
|US20030045920 *||25 oct. 2002||6 mars 2003||Medtronic, Inc.||Radiopaque marking of lead electrode zone in a continuous conductor construction|
|US20030149469 *||28 févr. 2003||7 août 2003||Lone Wolinsky||Medical device for intraluminal endovascular stenting|
|US20030158565 *||15 févr. 2002||21 août 2003||Medtronic, Inc.||Slitting tool|
|US20030181935 *||14 févr. 2003||25 sept. 2003||Medtronic, Inc.||Slitting tool|
|US20030199915 *||19 avr. 2002||23 oct. 2003||Peter Shimm||Laparoscopic specimen extraction port|
|US20030216773 *||8 mai 2003||20 nov. 2003||Peter Shimm||Laparoscopic specimen retrieval shoehorn|
|US20040064175 *||30 sept. 2002||1 avr. 2004||Lessar Joseph F.||Implantable medical device lead conductor having integral biostable in-situ grown oxide insulation and process for forming|
|US20040087900 *||1 nov. 2002||6 mai 2004||Thompson Paul J.||Implant delivery system with marker interlock|
|US20040138531 *||15 janv. 2003||15 juil. 2004||Bonner Matthew D.||Methods and apparatus for accessing and stabilizing an area of the heart|
|US20040193229 *||19 mai 2003||30 sept. 2004||Medtronic, Inc.||Gastric electrical stimulation for treatment of gastro-esophageal reflux disease|
|US20040230279 *||18 déc. 2003||18 nov. 2004||Cates Adam W.||Subcutaneous lead with tined fixation|
|US20040230280 *||18 déc. 2003||18 nov. 2004||Cates Adam W.||Helical fixation elements for subcutaneous electrodes|
|US20040230281 *||23 déc. 2003||18 nov. 2004||Ron Heil||Expandable fixation elements for subcutaneous electrodes|
|US20040230282 *||23 déc. 2003||18 nov. 2004||Cates Adam W.||Acute and chronic fixation for subcutaneous electrodes|
|US20040236381 *||19 mai 2003||25 nov. 2004||Medtronic, Inc.||Gastro-electric stimulation for reducing the acidity of gastric secretions or reducing the amounts thereof|
|US20040236382 *||19 mai 2003||25 nov. 2004||Medtronic, Inc.||Gastro-electric stimulation for increasing the acidity of gastric secretions or increasing the amounts thereof|
|US20050015117 *||30 avr. 2004||20 janv. 2005||Medtronic, Inc.||Method, system and device for treating disorders of the pelvic floor by electrical stimulation of and the delivery of drugs to the left and right pudendal nerves|
|US20050021008 *||30 avr. 2004||27 janv. 2005||Medtronic, Inc.||Method, system and device for treating disorders of the pelvic floor by drug delivery to the pudendal and sacral nerves|
|US20050033372 *||30 avr. 2004||10 févr. 2005||Medtronic, Inc.||Method, system and device for treating disorders of the pelvic floor by electrical stimulation of the left and the right sacral nerves|
|US20050060014 *||28 avr. 2004||17 mars 2005||Medtronic, Inc.||Implantable medical electrical stimulation lead fixation method and apparatus|
|US20050075701 *||8 avr. 2004||7 avr. 2005||Medtronic, Inc.||Device and method for attenuating an immune response|
|US20050075702 *||8 avr. 2004||7 avr. 2005||Medtronic, Inc.||Device and method for inhibiting release of pro-inflammatory mediator|
|US20050113877 *||26 nov. 2003||26 mai 2005||Medtronic, Inc.||Method, system and device for treating disorders of the pelvic floor by means of electrical stimulation of the pudenal and associated nerves, and the optional delivery of drugs in association therewith|
|US20050182435 *||12 févr. 2004||18 août 2005||Cardiac Pacemakers, Inc.||Notched cutter for guide catheter removal from lead|
|US20050240123 *||14 avr. 2004||27 oct. 2005||Mast T D||Ultrasound medical treatment system and method|
|US20050261610 *||21 mai 2004||24 nov. 2005||Mast T D||Transmit apodization of an ultrasound transducer array|
|US20060095077 *||29 oct. 2004||4 mai 2006||Tronnes Carole A||Expandable fixation structures|
|US20060095078 *||29 oct. 2004||4 mai 2006||Tronnes Carole A||Expandable fixation mechanism|
|US20060100683 *||6 nov. 2003||11 mai 2006||Yacoubian Vahe S||Epicardial heartwire, chest tube with epicardial heartwire, and method of use|
|US20060122659 *||30 avr. 2004||8 juin 2006||Medtronic, Inc.||Method, system and device for treating disorders of the pelvic floor by electrical stimulation of and the delivery of drugs to the left and right pudendal nerves|
|US20060129218 *||13 févr. 2006||15 juin 2006||Medtronic, Inc.||Implantable medical electrical stimulation lead fixation method and apparatus|
|US20060157511 *||5 nov. 2003||20 juil. 2006||Innovation Packaging||Device for packaging and dispensing a liquid or semi-liquid product|
|US20060173507 *||30 nov. 2005||3 août 2006||Ndi Medical, Llc||Systems for electrical stimulation of nerves in adipose tissue regions|
|US20060190046 *||30 avr. 2004||24 août 2006||Medtronic, Inc.||Method, system and device for treating disorders of the pelvic floor by electrical stimulation of the left and the right sacral nerves|
|US20060287678 *||29 août 2006||21 déc. 2006||Medtronic, Inc.||Device and method for inhibiting release of pro-inflammatory mediator|
|US20070049846 *||23 août 2006||1 mars 2007||C.R.Bard, Inc.||Stylet Apparatuses and Methods of Manufacture|
|US20070050004 *||30 oct. 2006||1 mars 2007||Medtronic, Inc.||Implantable medical lead including tine markers|
|US20070066995 *||7 sept. 2006||22 mars 2007||Ndi Medical, Llc||Implantable pulse generator systems and methods for providing functional and/or therapeutic stimulation of muscles and/or nerves and/or central nervous system tissue|
|US20070073370 *||27 sept. 2005||29 mars 2007||Zielinski Todd M||Trans-septal anchoring system and method|
|US20070135882 *||28 août 2006||14 juin 2007||Drasler William J||Cardiac stimulation system|
|US20070255333 *||28 avr. 2006||1 nov. 2007||Medtronic, Inc.||Neuromodulation therapy for perineal or dorsal branch of pudendal nerve|
|US20070255368 *||28 avr. 2006||1 nov. 2007||Bonde Eric H||Implantable medical electrical stimulation lead with distal fixation and method|
|US20070255370 *||28 avr. 2006||1 nov. 2007||Bonde Eric H||Implantable medical electrical stimulation lead, such as a PNE lead, and method of use|
|US20070293924 *||29 août 2007||20 déc. 2007||Belden Elisabeth L||Radiopaque marking of lead electrode zone in a continuous conductor construction|
|US20080046061 *||15 août 2007||21 févr. 2008||Yacoubian Vahe S||Heart wire|
|US20080108972 *||13 sept. 2007||8 mai 2008||Cardiac Pacemakers, Inc.||Universal cutter for guide catheters|
|US20080109054 *||7 mai 2007||8 mai 2008||Scimed Life Systems, Inc.||Leadless Cardiac Stimulation Systems|
|US20080183236 *||31 mars 2008||31 juil. 2008||Medtronic, Inc.||Method, system and device for treating disorders of the pelvic floor by electrical stimulation of the sacral and/or pudendal nerves|
|US20090069879 *||31 mars 2008||12 mars 2009||Ev3 Peripheral, Inc.||Implant delivery system with marker interlock|
|US20100022899 *||28 janv. 2010||Gernot Kolberg||Device for determining the flow rate of a blood flow, and cardiovascular assist device|
|US20100036227 *||11 févr. 2010||C. R. Bard, Inc.||Apparatus and display methods relating to intravascular placement of a catheter|
|US20100094116 *||7 oct. 2009||15 avr. 2010||Lucent Medical Systems, Inc.||Percutaneous magnetic gastrostomy|
|US20100217346 *||6 mai 2010||26 août 2010||Shuros Allan C||Method and apparatus for gastrointestinal stimulation via the lymphatic system|
|US20100256490 *||18 juin 2010||7 oct. 2010||Makin Inder Raj S||Medical system having an ultrasound source and an acoustic coupling medium|
|US20100268310 *||30 juin 2010||21 oct. 2010||Medtronic, Inc.||Implantable medical electrical stimulation lead, such as pne lead, and method of use|
|US20100312150 *||17 août 2010||9 déc. 2010||Mast T Douglas||System and method for medical treatment using ultrasound|
|US20100317981 *||14 juin 2010||16 déc. 2010||Romedex International Srl||Catheter Tip Positioning Method|
|US20100318026 *||16 déc. 2010||Romedex International Srl||Devices and Methods for Endovascular Electrography|
|US20100331712 *||9 sept. 2010||30 déc. 2010||Bard Access Systems, Inc.||Method of locating the tip of a central venous catheter|
|US20110190786 *||4 août 2011||Medtronic, Inc.||Introduction of medical lead into patient|
|US20110301543 *||8 déc. 2011||Interrad Medical, Inc.||Anchor Device and Method|
|US20120029335 *||2 févr. 2012||Cameron Health, Inc.||Subcutaneous Leads and Methods of Implant and Explant|
|USD699359||1 août 2012||11 févr. 2014||C. R. Bard, Inc.||Ultrasound probe head|
|USD724745||1 août 2012||17 mars 2015||C. R. Bard, Inc.||Cap for an ultrasound probe|
|USH1905 *||21 mars 1997||3 oct. 2000||Medtronic, Inc.||Mechanism for adjusting the exposed surface area and position of an electrode along a lead body|
|DE3048805A1 *||23 déc. 1980||17 sept. 1981||Medtronic Inc||Implantierbare leitung|
|DE3300050A1 *||3 janv. 1983||5 juil. 1984||Siemens Ag||Intravenous pacemaker electrode|
|EP0004967A2 *||17 avr. 1979||31 oct. 1979||Werner Dr.Dr. Mohl||Anchoring means for a probe head, particularly a cardiac probe|
|EP0009530A1 *||9 mars 1979||16 avr. 1980||Vitatron Medical B.V.||Atrial lead|
|EP0617978A2 *||31 mars 1994||5 oct. 1994||Medtronic, Inc.||Torque indicator for fixed screw leads|
|EP1034752A1||13 mars 2000||13 sept. 2000||Medtronic, Inc.||Method of stent retention to a delivery catheter balloon - braided retainers|
|EP2044972A1||25 sept. 2003||8 avr. 2009||Medtronic, Inc.||Implantable medical device lead conductor|
|WO1992012668A1 *||24 janv. 1992||6 août 1992||Univ Minnesota||Device and method for measurement of blood flow|
|WO1999008741A1 *||19 août 1998||25 févr. 1999||Abbeymoor Medical Inc||Urethral device with anchoring system|
|WO1999042171A1 *||11 févr. 1999||26 août 1999||Cardiac Pacemakers Inc||Coronary venous lead having fixation mechanism|
|WO2000067836A1||19 avr. 2000||16 nov. 2000||Ethicon Inc||Temporary pacing wire anchor|
|WO2001080941A2||24 avr. 2001||1 nov. 2001||Medtronics Inc||Medical electrical lead with fiber core|
|WO2004091717A2 *||9 avr. 2004||28 oct. 2004||Cardiac Pacemakers Inc||Subcutaneous cardiac lead with fixation|
|WO2007027506A2 *||23 août 2006||8 mars 2007||Medtronic Inc||Trans-septal pressure sensor|
|WO2007038646A1 *||26 sept. 2006||5 avr. 2007||Medtronic Inc||Trans-septal anchoring system and method|
|Classification aux États-Unis||607/126|