US4626255A - Heart valve bioprothesis - Google Patents
Heart valve bioprothesis Download PDFInfo
- Publication number
- US4626255A US4626255A US06/652,774 US65277484A US4626255A US 4626255 A US4626255 A US 4626255A US 65277484 A US65277484 A US 65277484A US 4626255 A US4626255 A US 4626255A
- Authority
- US
- United States
- Prior art keywords
- supporting frame
- posts
- external diameter
- annulus
- heart valve
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
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Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/02—Prostheses implantable into the body
- A61F2/24—Heart valves ; Vascular valves, e.g. venous valves; Heart implants, e.g. passive devices for improving the function of the native valve or the heart muscle; Transmyocardial revascularisation [TMR] devices; Valves implantable in the body
- A61F2/2412—Heart valves ; Vascular valves, e.g. venous valves; Heart implants, e.g. passive devices for improving the function of the native valve or the heart muscle; Transmyocardial revascularisation [TMR] devices; Valves implantable in the body with soft flexible valve members, e.g. tissue valves shaped like natural valves
- A61F2/2418—Scaffolds therefor, e.g. support stents
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S623/00—Prosthesis, i.e. artificial body members, parts thereof, or aids and accessories therefor
- Y10S623/90—Stent for heart valve
Definitions
- the invention concerns a heart valve bioprosthesis with a fixed, integral aortic valve of animal origin which is positioned in an resiliently flexible, fabric-covered supporting frame having substantially the shape of a cylinder with a substantially circular cross-section.
- the cylinder consists of an axially slightly undulatory annulus comprising three complete waves and of three rounded posts which are positioned at equidistant angles, and extend axially from the wave apices. These furthermore have number of perforations, the fabric being shaped as a suture ring near the end face opposite to the posts and the annulus, fibrosus from which the three aortic leaflets orrginate.
- the latter is due to the rigid root of the right aortic leaflet which rests several millimeters on the muscular ventricular septum of the porcine heart. After removal and preparation of the valve the adhering remnants of muscular tissue become inelastic due to the process of fixation with glutaraldehyde, whereby the mobility of the right leaflet is impaired.
- New methods have been developed in an attempt to solve this problem (reduction of the supporting cylinder height, modified fixing agents, low pressure fixation) and have lead to a modification of porcine bioprostheses.
- the invention is based on the recognition of the fact that in previously used porcine xenografts the basis of the right leaflet--seen from its attachment to the annulus fibrosus--coalesces for several millimeters with the muscular bulge of the ventricular septum.
- porcine xenografts the basis of the right leaflet--seen from its attachment to the annulus fibrosus--coalesces for several millimeters with the muscular bulge of the ventricular septum.
- an attempt was made to remove any muscular tissue impairing the mobility of the right leaflet by preparation of the right leaflet starting from the annulus fibrosus. This was accomplished by mechanical means, i.e. scraping. Apart from expensive production procedures it is impossible to completely remove the impeding muscular tissue, so that during the following fixation process with 2% glutaraldehyde solution the remaining muscular fibres become rigid, thus impeding the mobility of the right leaflet near its root.
- the object of the invention is to provide a heart valve bioprosthesis of the type mentioned above, in which the mobility, particularly of the right leaflet should resemble the mobility of a human valve as closely as possible whilst retaining the origination of the leaflet from an annulus fibrosus sutured to the lower rim of the fabric and without individual leaflets having to be assembled from different aortic valves.
- the invention solves this problem by using an animal aortic valve in which the right leaflet as well as the other two leaflets protrude almost completely unobstructed from the annulus fibrosus into the aortic lumen, without being coalesced with muscular tissue of the ventricular septum.
- a preferred embodiment of the invention is characterized in that the aortic valve has the shape, size and structure of a fixed aortic valve of an adult kangaroo, i.e. the aortic valve is preferably the fixed aortic valve of an adult kangaroo.
- the invention is based on the recognition of the fact that it is important for an aortic valve, deadened by means of the process of fixation, to originate from the annulus fibrosus being attached to the dacron fabric in the area of the lower rim of the supporting frame, while not being coalesced at all with the muscular tissue of the ventricular septum, or only to such a minimal degree that mobility is hardly impaired.
- This requirement is ideally met by the aortic valve of a preferably male red or grey giant kangaroo of the species Macropus giganteus or Macropus rufus.
- the production of the aortic valves involves the removal of the aortic root along with the adjoining myocardium and an aortic stump of several centimeters from a prefixed heart.
- the advantage of the use of fixed aortic valves of the kangaroo lies particularly in the fact that the aortic wall extends along the sinus valsalvae with its elastic fibres and the smooth muscles up to the protruding muscular torus. Only then a very small, flat annulus fibrosus originates from this point, and is anchored to the muscular tissue of the septum by small individual collagenous fibre fingers. The right leaflet does not rest on the muscular torus, and does originate almost completely unimpeded from the annulus fibrosus into the aortic lumen.
- the invention comprises a heart valve prosthesis in which the origin of the right leaflet together with the much smaller annulus fibrosus is much shorter in relation, to the total diameter of the aortic ostium, than is the case with porcine xenografts.
- porcine xenografts thereby the portion of the right leaflet which is immobile after the process of fixing is reduced, which results in a significantly wider valvular lumen during the opening cycle compared to porcine xenografts.
- the valves according to the present invention are used as xenografts less significant pressure changes occur than in the case of porcine valves.
- Aortic valves of the kangaroos can be produced in sizes between 17 mm and 31 mm. They can be used as replacement valves in any of the four positions of the heart, e.g. they can be employed as aortic or as mitral valves.
- the supporting frame consists preferably of a thermally very stable plastic, for example an acetyl-copolymer resin (Delrin).
- the fabric covering the frame is usually a double-knitted polyester product.
- the frame is shaped according to one of the forns disclosed herein.
- the width of the posts intended for the arrangement of the commissures is according to invention about 1/4 of the outer diameter of the carrier frame; furthermore according to invention the equidistant commissure posts are broad enough so as to allow a tolerance of 30° in the arrangement of the commissures.
- kangaroo aortic valves show a variation in the arrangement of commissures of approximately 15°.
- the supporting frame exhibits considerably shorter commissure posts compared to supporting frames used for porcine valves to date.
- the total profile is also lower in the axial direction.
- the entrance edge facing away from the posts has an undulation gentle enough to not only allow a flat mitral suture ring to be fitted on, but also a curved aortic suture ring.
- the prosthesis can be especially advantageously integrated according to invention within a vascular prosthesis with a built in cardiac valve.
- the supporting frame's numerous holes, slots, oblong perforations, borings which have been provided in every part of the frame and which not only serve to improve the elasticity of the frame considerably, but also offer plenty of possibilities for attachment of the tube-shaped dacron fabric which covers the frame from all sides.
- the width of the annular area has been chosen in such a way that a maximum of space for free mobility of the leaflets is available.
- FIG. 1 a side view of a heart valve prosthesis
- FIG. 2 a view of the object in FIG. 1 as seen from below
- FIG. 3 a side view of the supporting frame used in the artificial heart valve prosthesis depicted in FIGS. 1 and 2,
- FIG. 3a the supporting frame according to FIG. 3 evolved into a plane
- FIG. 4 a view of the supporting frame according to FIG. 3 from below.
- the supporting frame 22 (FIGS. 3, 4) which is covered on both sides with a polyester or dacron fabric 23 and consists itself of an acetyl resin, Delrin for example, has an essentially circular, cylindrical shape.
- the material 23 On the lower end face or lower edge 11 the material 23 has been folded to form a suture ring 14 in which an elastic supporting ring can be placed surrounding the lower edge 11 of the supporting frame 22.
- the suture ring 14 is determined for suturing the heart valve prosthesis to human tissue, to the aorta for example.
- the supporting frame consists of strip- or band-like material coiled up to a cylindrical shape, the thickness of which is about 1/40th of the external diameter of the carrier frame 22.
- the band-like material has a gently waved annulus 13 with three complete undulations, each undulation consisting of a wave crest and a wave trough and a post 12 extending axially in the opening direction of the leaflets 15, 16, 17, (FIGS. 1, 2) from each crest.
- Each post 12 has an axially directed oblong perforation in the shape of two semicircles mutually connected by straight lines.
- the radius of the semicircles is 0.64 times the external diameter of the supporting frame 22.
- the distance of both centres of the semicircles is about 1/10th of the external diameter of the supporting frame 22.
- the posts 12 are rounded in correspondence to the upper semicircle of the oblong perforations 19 so that a width of material equalling 1/16th of the external diameter of the supporting frame 22 remains between the oblong perforations 19 and the upper end face or edge 24 of the posts 12.
- the annulus 13 is bordered above by the upper edge 24 having the shape of a concave arc of a circle with the centre of curvature 27 situated in the middle of the connecting line 30 extending between the apices 28 of two adjacent posts 12.
- the upper edge 24 is approximately semi-circular in shape and merges through a reversing point 33 into the upper region of the posts 12 including the apices 28.
- a round hole 20 is provided in the annulus 13, the diameter of which is smaller than the external diameter of the supporting frame 22 by a factor of 0.093.
- the hole 20 is positioned in the middle between the oblong perforation 19 and the lower edge 11 of the annulus 13.
- the lower edge 11 of the supporting frame 22 has a concave circular curvature in the region where the posts 12 are positioned.
- the centre of curvature 29 lies on the mid-axis 34 of the oblong perforation 19 in distinct distance from the connecting line 31 between adjacent apices 32 of the undulating lower edge 11, that is on the side of the connecting line 31 which faces away from the post 12.
- the preferable distance between the centre of curvature 29 and the connecting line 31 should be about half of the external diameter of the supporting frame 22.
- the radius of the circle around the centre of curvature 29 is about 50% larger than the radius of the circle around the upper centre of curvature 27, and is conveniently 0.6 times the external diameter of the supporting frame 22.
- the centres of curvature 27 and 29 are displaced peripherally by an angle of 60°.
- the apices 28 and 32 are also displaced peripherally by an angle of 60°.
- the circularly curved portion of the lower edge 11 with the centre of curvature 29 merges through reversing points 37 into circular convex curved portions lying in the region of the apices 32 and having approximately the same radius of curvature as the region with the centre 29.
- a longitudinal slot 26 is positioned to both sides of the boring 25 at a distance of approximately the diameter of the boring 25, the slot 26 being curved in correspondence to the circular concave part of the upper edge 24 and extending parallel to this part of the upper edge 14.
- the slots 26 extend approximately to the origin of the posts 12 and terminate in a distance from the oblong perforations 19 and the holes 20, respectively which corresponds approximately to the width of the oblong perforations 19.
- the edge 11 runs parallel to the upper edge 24 in the region of the apices 32.
- the supporting frame is, after the attachment of dacron material 23, according to FIGS. 1 and 2, ideally suited for the attachment of a kangaroo aortic valve including the aortic stump 40.
- the leaflets 15,16,17 (FIGS. 1, 2) can open perfectly and completely and also close without impedement.
- the carrier frame according to the present invention Due to the construction of the carrier frame according to the present invention excellent elasticity is obtained which corresponds to a high degree to the elasticity of the aorta or that section of the heart into which the prosthesis is implanted. Thus the heart valve prosthesis does not affect the natural deformations of those parts of the human tissue it comes into contact with, to a harmful degree.
- the numerous perforations in the plastic supporting frame 22 furnish highly satisfactory possibilities for fastening on the dacron fabric to the pulled over.
- the dacron fabric is pulled over and sutured in the usual manner.
- the aortic valve of a kangaroo including the aortic stump 40 which have been deadened and preserved by fixation is inserted into the supporting frame 22 which is covered with the fabric 23.
- the aortic valve consists of the annulus fibrosus 18 as well as of the three leaflets 15,16,17 originating therefrom, namely the right leaflet 15, the a-coronary leaflet 16, and the left leaflet 17.
- leaflets are called velums.
- the annulus fibrosus 18 For mounting the annulus fibrosus 18 is positioned at the lower edge 11 of the supporting frame 22 and the aortic stump 40 extending from the annulus fibrosus 18 and being cut out according to the shape of the edge 24 (FIG. 3a) is arranged in the interior along the annulus 13 and the posts 12 and is sutured in the area of the upper edge 24 (FIGS. 3, 3a) with the fabric 23, whereby the suture 35 is formed.
- the annulus fibrosus 18 is sutured to the fabric 23 at the suture ring 14, whereby the suture 36 (FIG. 1) is formed.
- heart valve prosthesis works according to the invention in the following manner:
- the leaflets 15,16,17 open upwards in a valve-like manner and lead, due to the design according to invention, to an opening cross-section of at least 70%, generally 75% and under circumstances to even 80% of the cross-section area of the aortic lumen.
- the pressure gradient arising on both sides of the heart valve prosthesis during opening is kept at a desirable minimum.
- the valves 15, 16, 17 return to their resting position as can be seen in FIGS. 1, 2, whereby they come into contact with each other and form a seal along the commissure lines 21 in FIG. 2 so that any leaking of blood is prevented.
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- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Cardiology (AREA)
- Oral & Maxillofacial Surgery (AREA)
- Transplantation (AREA)
- Heart & Thoracic Surgery (AREA)
- Vascular Medicine (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Prostheses (AREA)
Abstract
Description
Claims (11)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
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DE3334512 | 1983-09-23 | ||
DE3334512 | 1983-09-23 |
Publications (1)
Publication Number | Publication Date |
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US4626255A true US4626255A (en) | 1986-12-02 |
Family
ID=6209904
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
US06/652,774 Expired - Fee Related US4626255A (en) | 1983-09-23 | 1984-09-19 | Heart valve bioprothesis |
Country Status (1)
Country | Link |
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US (1) | US4626255A (en) |
Cited By (160)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4790844A (en) * | 1987-01-30 | 1988-12-13 | Yoel Ovil | Replacement of cardiac valves in heart surgery |
US4892541A (en) * | 1982-11-29 | 1990-01-09 | Tascon Medical Technology Corporation | Heart valve prosthesis |
US5258023A (en) * | 1992-02-12 | 1993-11-02 | Reger Medical Development, Inc. | Prosthetic heart valve |
US5366504A (en) * | 1992-05-20 | 1994-11-22 | Boston Scientific Corporation | Tubular medical prosthesis |
US5449385A (en) * | 1991-05-08 | 1995-09-12 | Nika Health Products Limited | Support for a heart valve prosthesis |
GB2295333A (en) * | 1994-10-11 | 1996-05-29 | Astec Environmental Sys Ltd | Filter Mounting |
WO1996040008A1 (en) * | 1995-06-07 | 1996-12-19 | St. Jude Medical, Inc. | Bioprosthetic heart valve stent having integral supporting structure |
US5814096A (en) * | 1996-01-05 | 1998-09-29 | Baxter International Inc. | Sizing obturator for prosthetic aortic valves |
US5824061A (en) * | 1989-05-31 | 1998-10-20 | Baxter International Inc. | Vascular and venous valve implant prostheses |
US5861028A (en) * | 1996-09-09 | 1999-01-19 | Shelhigh Inc | Natural tissue heart valve and stent prosthesis and method for making the same |
US5928281A (en) * | 1997-03-27 | 1999-07-27 | Baxter International Inc. | Tissue heart valves |
US5935163A (en) * | 1998-03-31 | 1999-08-10 | Shelhigh, Inc. | Natural tissue heart valve prosthesis |
WO1999066863A2 (en) * | 1998-06-24 | 1999-12-29 | Sulzer Carbomedics Inc. | Altering heart valve leaflet attachment geometry to influence the location and magnitude of maximum loaded stress on the leaflet |
US6019739A (en) * | 1998-06-18 | 2000-02-01 | Baxter International Inc. | Minimally invasive valve annulus sizer |
US6350281B1 (en) | 1999-09-14 | 2002-02-26 | Edwards Lifesciences Corp. | Methods and apparatus for measuring valve annuluses during heart valve-replacement surgery |
US6350282B1 (en) * | 1994-04-22 | 2002-02-26 | Medtronic, Inc. | Stented bioprosthetic heart valve |
US6461382B1 (en) | 2000-09-22 | 2002-10-08 | Edwards Lifesciences Corporation | Flexible heart valve having moveable commissures |
US6558418B2 (en) | 1999-01-26 | 2003-05-06 | Edwards Lifesciences Corporation | Flexible heart valve |
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US20040176839A1 (en) * | 2000-06-01 | 2004-09-09 | Huynh Van Le | Low-profile heart valve sewing ring and method of use |
US20040254636A1 (en) * | 2003-05-28 | 2004-12-16 | Flagle Jacob A. | Prosthetic valve with vessel engaging member |
US20050096738A1 (en) * | 2003-10-06 | 2005-05-05 | Cali Douglas S. | Minimally invasive valve replacement system |
US20050187618A1 (en) * | 2004-02-19 | 2005-08-25 | Shlomo Gabbay | Low profile heart valve prosthesis |
US20060229718A1 (en) * | 2005-04-06 | 2006-10-12 | Salvador Marquez | Stress absorbing flexible heart valve frame |
US20060276889A1 (en) * | 2005-06-07 | 2006-12-07 | Chambers Freeman G | Systems and methods for assembling components of a fabric-covered prosthetic heart valve |
WO2008065678A2 (en) * | 2006-11-29 | 2008-06-05 | Aparna Thirumalai Anandampilla | An improved heart valve |
US20090076599A1 (en) * | 2007-09-17 | 2009-03-19 | Medtronics, Inc. | Heart valve holder assembly for use in valve implantation procedures |
US20100161036A1 (en) * | 2008-12-19 | 2010-06-24 | Edwards Lifesciences Corporation | Quick-connect prosthetic heart valve and methods |
GR1007028B (en) * | 2009-11-11 | 2010-10-22 | Ευσταθιος-Ανδρεας Αγαθος | SUPPORT OF BIO-ADDITIONAL VALVES WITH DIAGNOSTIC HEART SHAPE |
US7819915B2 (en) | 2000-07-27 | 2010-10-26 | Edwards Lifesciences Corporation | Heart valve holders and handling clips therefor |
US20100331972A1 (en) * | 2009-06-26 | 2010-12-30 | Edwards Lifesciences Corporation | Unitary Quick Connect Prosthetic Heart Valve and Deployment System and Methods |
WO2011051574A1 (en) | 2009-10-15 | 2011-05-05 | Olivier Schussler | Method for producing implantable medical bioprostheses having reduced calcification properties |
US7951197B2 (en) | 2005-04-08 | 2011-05-31 | Medtronic, Inc. | Two-piece prosthetic valves with snap-in connection and methods for use |
US7959674B2 (en) | 2002-07-16 | 2011-06-14 | Medtronic, Inc. | Suture locking assembly and method of use |
US7967857B2 (en) | 2006-01-27 | 2011-06-28 | Medtronic, Inc. | Gasket with spring collar for prosthetic heart valves and methods for making and using them |
US7972377B2 (en) | 2001-12-27 | 2011-07-05 | Medtronic, Inc. | Bioprosthetic heart valve |
US7981153B2 (en) | 2002-12-20 | 2011-07-19 | Medtronic, Inc. | Biologically implantable prosthesis methods of using |
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US8021161B2 (en) | 2006-05-01 | 2011-09-20 | Edwards Lifesciences Corporation | Simulated heart valve root for training and testing |
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US10080653B2 (en) | 2015-09-10 | 2018-09-25 | Edwards Lifesciences Corporation | Limited expansion heart valve |
US10201419B2 (en) | 2014-02-05 | 2019-02-12 | Tendyne Holdings, Inc. | Apparatus and methods for transfemoral delivery of prosthetic mitral valve |
US10231833B2 (en) | 2016-10-28 | 2019-03-19 | Foldax, Inc. | Prosthetic heart valves with elastic support structures and related methods |
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US10314697B2 (en) | 2014-08-18 | 2019-06-11 | W. L. Gore & Associates, Inc. | Frame with integral sewing cuff for prosthetic valves |
US10327894B2 (en) | 2015-09-18 | 2019-06-25 | Tendyne Holdings, Inc. | Methods for delivery of prosthetic mitral valves |
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