US4729892A - Use of cross-linked hydrogel materials as image contrast agents in proton nuclear magnetic resonance tomography and tissue phantom kits containing such materials - Google Patents
Use of cross-linked hydrogel materials as image contrast agents in proton nuclear magnetic resonance tomography and tissue phantom kits containing such materials Download PDFInfo
- Publication number
- US4729892A US4729892A US06/842,337 US84233786A US4729892A US 4729892 A US4729892 A US 4729892A US 84233786 A US84233786 A US 84233786A US 4729892 A US4729892 A US 4729892A
- Authority
- US
- United States
- Prior art keywords
- hydrogel
- spin
- materials
- cross
- magnetic resonance
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01R—MEASURING ELECTRIC VARIABLES; MEASURING MAGNETIC VARIABLES
- G01R33/00—Arrangements or instruments for measuring magnetic variables
- G01R33/20—Arrangements or instruments for measuring magnetic variables involving magnetic resonance
- G01R33/44—Arrangements or instruments for measuring magnetic variables involving magnetic resonance using nuclear magnetic resonance [NMR]
- G01R33/48—NMR imaging systems
- G01R33/54—Signal processing systems, e.g. using pulse sequences ; Generation or control of pulse sequences; Operator console
- G01R33/56—Image enhancement or correction, e.g. subtraction or averaging techniques, e.g. improvement of signal-to-noise ratio and resolution
- G01R33/5601—Image enhancement or correction, e.g. subtraction or averaging techniques, e.g. improvement of signal-to-noise ratio and resolution involving use of a contrast agent for contrast manipulation, e.g. a paramagnetic, super-paramagnetic, ferromagnetic or hyperpolarised contrast agent
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
- A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
- A61K49/18—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by a special physical form, e.g. emulsions, microcapsules, liposomes
- A61K49/1803—Semi-solid preparations, e.g. ointments, gels, hydrogels
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S436/00—Chemistry: analytical and immunological testing
- Y10S436/806—Electrical property or magnetic property
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
- Y10T436/00—Chemistry: analytical and immunological testing
- Y10T436/24—Nuclear magnetic resonance, electron spin resonance or other spin effects or mass spectrometry
Abstract
Description
T.sub.1 =320±34 ms
T.sub.2 =52±3 ms.
T.sub.1 =1330±400
T.sub.2 =294±55.
T.sub.1 =390±120
T.sub.2 =44±16.
T.sub.1 =1800±220
T.sub.2 =340±80.
T.sub.1 =1670±400
T.sub.2 =294±92.
T.sub.1 =1470±300 ms
T.sub.2 =174±30 ms.
T.sub.1 =250 ±60
T.sub.2 =56 ±10.
R.sub.f --CH.sub.2 CH.sub.2 --SCONHCH.sub.2 CH.sub.2 OCO--C(CH.sub.3) =CH.sub.2
______________________________________ Composition, %.sup.(1) Product MAC MMA DMA NVP HEMA EHA ______________________________________ 18a 30 70 18b 30 42 28 18c 20 45 35 18d 12 27.5 33 27.5 ______________________________________ Properties Products T.sub.1 T.sub.2 % H.sub.2 O ______________________________________ 18a 155 16 23.0 18b 34 4 25.4 18c 43 4 49.0 18d 115 17 8.0 ______________________________________ .sup.(1) MAC = macromer of Example 1 MMA = methyl methacrylate DMA = dimethyl acrylamide NVP = N--vinyl pyrrolidone HEMA = 2hydroxyethyl methacrylate EHA = 2ethylhexyl acrylate
Claims (10)
Priority Applications (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US06/842,337 US4729892A (en) | 1986-03-21 | 1986-03-21 | Use of cross-linked hydrogel materials as image contrast agents in proton nuclear magnetic resonance tomography and tissue phantom kits containing such materials |
CA000532415A CA1279819C (en) | 1986-03-21 | 1987-03-19 | Use of cross-linked hydrogel materials as image contrast agents in proton nuclear magnetic resonance tomography and tissue phantom kits containing such materials |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US06/842,337 US4729892A (en) | 1986-03-21 | 1986-03-21 | Use of cross-linked hydrogel materials as image contrast agents in proton nuclear magnetic resonance tomography and tissue phantom kits containing such materials |
Publications (1)
Publication Number | Publication Date |
---|---|
US4729892A true US4729892A (en) | 1988-03-08 |
Family
ID=25287093
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
US06/842,337 Expired - Lifetime US4729892A (en) | 1986-03-21 | 1986-03-21 | Use of cross-linked hydrogel materials as image contrast agents in proton nuclear magnetic resonance tomography and tissue phantom kits containing such materials |
Country Status (2)
Country | Link |
---|---|
US (1) | US4729892A (en) |
CA (1) | CA1279819C (en) |
Cited By (45)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4967764A (en) * | 1988-10-24 | 1990-11-06 | The United States Of America As Represented By The Department Of Health And Human Services | Pressure sensor element to measure contact stress |
EP0409351A1 (en) * | 1989-07-21 | 1991-01-23 | Nycomed Imaging As | Contrast medium composition |
US5023185A (en) * | 1986-12-17 | 1991-06-11 | Nippon Oil Co., Ltd. | Method for determining resolution power or discrimination capacity of an NMR imaging apparatus |
US5045304A (en) * | 1988-08-31 | 1991-09-03 | Wayne State University | Contras agent having an imaging agent coupled to viable granulocytes for use in magnetic resonance imaging of abscess and a method of preparing and using same |
WO1991015753A1 (en) * | 1990-04-10 | 1991-10-17 | Unger Evan C | Polymers as contrast media for magnetic resonance imaging |
US5071602A (en) * | 1987-08-27 | 1991-12-10 | Nippon Oil Co., Ltd. | Method of making phantom for nmr diagnosis |
US5079006A (en) * | 1987-07-15 | 1992-01-07 | Aprex Corporation | Pharmaceutical compositions containing a magnetically detectable material |
US5125408A (en) * | 1988-10-24 | 1992-06-30 | The United States Of America As Represented By The Of The Department Of Health And Human Services | Pressure sensor element and method to measure contact stress |
US5145661A (en) * | 1988-08-31 | 1992-09-08 | Wayne State University | Method and contrast agent for use in magnetic resonance imaging of abscess |
EP0502814A2 (en) * | 1991-02-15 | 1992-09-09 | BRACCO International B.V. | Compositions for increasing the image contrast in imaging of the digestive tract of patients |
WO1993010163A2 (en) * | 1991-11-12 | 1993-05-27 | Nepera, Inc. | Adhesive hydrogels having extended use lives and process for the preparation of same |
WO1994008509A1 (en) * | 1992-10-13 | 1994-04-28 | Unger Evan C | Polymers as contrast media for magnetic resonance imaging |
US5312755A (en) * | 1989-02-24 | 1994-05-17 | Wisconsin Alumni Research Foundation | Contrast resolution tissue mimicking phantoms for nuclear magnetic resonance imaging with stable NMR properties |
US5380514A (en) * | 1990-03-24 | 1995-01-10 | The Victoria University Of Manchester | Method for magnetic resonance imaging of internal body tissues using polysiloxanes |
US5385719A (en) * | 1991-09-24 | 1995-01-31 | Unger; Evan C. | Copolymers and their use as contrast agents in magnetic resonance imaging and in other applications |
US5393525A (en) * | 1989-07-21 | 1995-02-28 | Nycomed Imaging As | Contrast medium comprising superparamagnetic or ferromagnetic particles capable of increasing viscosity after administration |
US5532006A (en) * | 1993-04-23 | 1996-07-02 | The Board Of Trustees Of The University Of Illinois | Magnetic gels which change volume in response to voltage changes for MRI |
US5551429A (en) * | 1993-02-12 | 1996-09-03 | Fitzpatrick; J. Michael | Method for relating the data of an image space to physical space |
US6318146B1 (en) * | 1999-07-14 | 2001-11-20 | Wisconsin Alumni Research Foundation | Multi-imaging modality tissue mimicking materials for imaging phantoms |
US6333971B2 (en) | 1995-06-07 | 2001-12-25 | George S. Allen | Fiducial marker |
US6410616B1 (en) * | 1998-04-09 | 2002-06-25 | Nippon Shokubai Co., Ltd | Crosslinked polymer particle and its production process and use |
US20030100830A1 (en) * | 2001-11-27 | 2003-05-29 | Sheng-Ping Zhong | Implantable or insertable medical devices visible under magnetic resonance imaging |
US6675035B1 (en) | 1997-06-20 | 2004-01-06 | Imaging Diagnostic Systems, Inc. | Phantom for optical and magnetic resonance imaging quality control |
US20040067591A1 (en) * | 2002-10-04 | 2004-04-08 | Wisconsin Alumni Research Foundation | Tissue mimicking elastography phantoms |
JP2005104842A (en) * | 2003-09-26 | 2005-04-21 | Mitsui Chemicals Inc | New (meth)acrylate having thiourethane skeleton |
US6965235B1 (en) | 2003-07-24 | 2005-11-15 | General Electric Company | Apparatus to simulate MR properties of human brain for MR applications evaluation |
WO2008021720A2 (en) * | 2006-08-14 | 2008-02-21 | Artann Laboratories, Inc. | Human tissue phantoms and methods for manufacturing thereof |
US20080077006A1 (en) * | 2004-08-25 | 2008-03-27 | Koninklijke Philips Electronics, N.V. | Mr Method of Determining Local Relaxation Time Values Using Calibrated Phantom |
US20130022548A1 (en) * | 2009-12-14 | 2013-01-24 | Bennett Kevin M | Methods and Compositions Relating to Reporter Gels for Use in MRI Techniques |
US20140356967A1 (en) * | 2011-12-28 | 2014-12-04 | Hitachi, Ltd. | Tissue mimicking phantom and calibration device |
WO2017161239A1 (en) * | 2016-03-18 | 2017-09-21 | Q Bio, Inc. | System and method for magnetic resonance elastography |
US9958521B2 (en) | 2015-07-07 | 2018-05-01 | Q Bio, Inc. | Field-invariant quantitative magnetic-resonance signatures |
US10194829B2 (en) | 2015-07-07 | 2019-02-05 | Q Bio, Inc. | Fast scanning based on magnetic resonance history |
US10222441B2 (en) | 2016-04-03 | 2019-03-05 | Q Bio, Inc. | Tensor field mapping |
US10359486B2 (en) | 2016-04-03 | 2019-07-23 | Q Bio, Inc. | Rapid determination of a relaxation time |
US10635833B2 (en) | 2015-09-12 | 2020-04-28 | Q Bio, Inc. | Uniform-frequency records with obscured context |
US10936180B2 (en) | 2017-03-16 | 2021-03-02 | Q Bio, Inc. | User interface for medical information |
US10964412B2 (en) | 2015-10-20 | 2021-03-30 | Q Bio, Inc. | Population-based medical rules via anonymous sharing |
US11131735B2 (en) | 2019-09-27 | 2021-09-28 | Q Bio, Inc. | Maxwell parallel imaging |
US11181601B1 (en) | 2020-05-19 | 2021-11-23 | Wisconsin Alumni Research Foundation | Systems and methods for magnetic resonance phantoms |
US11354586B2 (en) | 2019-02-15 | 2022-06-07 | Q Bio, Inc. | Model parameter determination using a predictive model |
US11360166B2 (en) | 2019-02-15 | 2022-06-14 | Q Bio, Inc | Tensor field mapping with magnetostatic constraint |
US11614508B1 (en) | 2021-10-25 | 2023-03-28 | Q Bio, Inc. | Sparse representation of measurements |
US11614509B2 (en) | 2019-09-27 | 2023-03-28 | Q Bio, Inc. | Maxwell parallel imaging |
US11650195B2 (en) | 2017-02-03 | 2023-05-16 | Q Bio, Inc. | Iterative medical testing of biological samples |
Citations (19)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US2976576A (en) * | 1956-04-24 | 1961-03-28 | Wichterle Otto | Process for producing shaped articles from three-dimensional hydrophilic high polymers |
US3220960A (en) * | 1960-12-21 | 1965-11-30 | Wichterle Otto | Cross-linked hydrophilic polymers and articles made therefrom |
US3488111A (en) * | 1967-03-16 | 1970-01-06 | Nat Patent Dev Corp | Hydrophilic hydrogel corneal contact lens with hard central insert |
US3532679A (en) * | 1969-04-07 | 1970-10-06 | Robert Steckler | Hydrogels from cross-linked polymers of n-vinyl lactams and alkyl acrylates |
US3639524A (en) * | 1969-07-28 | 1972-02-01 | Maurice Seiderman | Hydrophilic gel polymer insoluble in water from polyvinylpyrrolidone with n-vinyl-2-pyrrolidone and methacrylic modifier |
US3647736A (en) * | 1970-05-25 | 1972-03-07 | Kontur Kontact Lens Co Inc | Hydrophilic contact lens material |
US3700761A (en) * | 1969-11-28 | 1972-10-24 | Griffin Lab Inc | Fabrication of soft plastic contact lens blank |
US3728317A (en) * | 1971-05-03 | 1973-04-17 | Hydrophilics Int Inc | Optical contact lenses and related devices |
US3758448A (en) * | 1971-10-05 | 1973-09-11 | Union Optics Corp | Copolymers and hydrogels of unsaturated esters |
US3772235A (en) * | 1971-10-05 | 1973-11-13 | Union Optics Corp | Copolymers and hydrogels of unsaturated heterocyclic compounds |
US3803093A (en) * | 1971-02-25 | 1974-04-09 | C Neefe | Methyl methacrylate copolymer which may be hydrated |
US3813447A (en) * | 1970-09-19 | 1974-05-28 | Toyo Contact Lens Co Ltd | Hydrophilic synthetic high polymers for soft contact lenses and a process for manufacturing the same |
US3816571A (en) * | 1969-11-28 | 1974-06-11 | Warner Lambert Co | Fabrication of soft plastic lens |
US3822196A (en) * | 1969-11-28 | 1974-07-02 | Warner Lambert Co | Fabrication of soft plastic contact lens blank and composition therefor |
US3841985A (en) * | 1969-11-28 | 1974-10-15 | Warner Lambert Co | Irradiated composition for soft contact lens |
US4136250A (en) * | 1977-07-20 | 1979-01-23 | Ciba-Geigy Corporation | Polysiloxane hydrogels |
US4192827A (en) * | 1974-06-27 | 1980-03-11 | Ciba-Geigy Corporation | Water-insoluble hydrophilic copolymers |
US4224427A (en) * | 1978-06-01 | 1980-09-23 | Ciba-Geigy Corporation | Process for preparing hydrogels as spherical beads of large size |
US4347198A (en) * | 1977-09-12 | 1982-08-31 | Toray Industries, Ltd. | Producing soft contact lenses |
-
1986
- 1986-03-21 US US06/842,337 patent/US4729892A/en not_active Expired - Lifetime
-
1987
- 1987-03-19 CA CA000532415A patent/CA1279819C/en not_active Expired - Lifetime
Patent Citations (21)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US2976576A (en) * | 1956-04-24 | 1961-03-28 | Wichterle Otto | Process for producing shaped articles from three-dimensional hydrophilic high polymers |
US3220960A (en) * | 1960-12-21 | 1965-11-30 | Wichterle Otto | Cross-linked hydrophilic polymers and articles made therefrom |
US3488111A (en) * | 1967-03-16 | 1970-01-06 | Nat Patent Dev Corp | Hydrophilic hydrogel corneal contact lens with hard central insert |
US3532679A (en) * | 1969-04-07 | 1970-10-06 | Robert Steckler | Hydrogels from cross-linked polymers of n-vinyl lactams and alkyl acrylates |
US3721657A (en) * | 1969-07-28 | 1973-03-20 | M Seiderman | Hydrophilic gel polymers of vinylpyrrolidine and hydroxyalkyl methacrylate |
US3639524A (en) * | 1969-07-28 | 1972-02-01 | Maurice Seiderman | Hydrophilic gel polymer insoluble in water from polyvinylpyrrolidone with n-vinyl-2-pyrrolidone and methacrylic modifier |
US3767731A (en) * | 1969-07-28 | 1973-10-23 | M Seiderman | Contact lenses from hydrophilic gel polymers of polyvinylpyrrolidone monomeric vinylpyrrolidone and methacrylic modifier |
US3822196A (en) * | 1969-11-28 | 1974-07-02 | Warner Lambert Co | Fabrication of soft plastic contact lens blank and composition therefor |
US3841985A (en) * | 1969-11-28 | 1974-10-15 | Warner Lambert Co | Irradiated composition for soft contact lens |
US3700761A (en) * | 1969-11-28 | 1972-10-24 | Griffin Lab Inc | Fabrication of soft plastic contact lens blank |
US3816571A (en) * | 1969-11-28 | 1974-06-11 | Warner Lambert Co | Fabrication of soft plastic lens |
US3647736A (en) * | 1970-05-25 | 1972-03-07 | Kontur Kontact Lens Co Inc | Hydrophilic contact lens material |
US3813447A (en) * | 1970-09-19 | 1974-05-28 | Toyo Contact Lens Co Ltd | Hydrophilic synthetic high polymers for soft contact lenses and a process for manufacturing the same |
US3803093A (en) * | 1971-02-25 | 1974-04-09 | C Neefe | Methyl methacrylate copolymer which may be hydrated |
US3728317A (en) * | 1971-05-03 | 1973-04-17 | Hydrophilics Int Inc | Optical contact lenses and related devices |
US3772235A (en) * | 1971-10-05 | 1973-11-13 | Union Optics Corp | Copolymers and hydrogels of unsaturated heterocyclic compounds |
US3758448A (en) * | 1971-10-05 | 1973-09-11 | Union Optics Corp | Copolymers and hydrogels of unsaturated esters |
US4192827A (en) * | 1974-06-27 | 1980-03-11 | Ciba-Geigy Corporation | Water-insoluble hydrophilic copolymers |
US4136250A (en) * | 1977-07-20 | 1979-01-23 | Ciba-Geigy Corporation | Polysiloxane hydrogels |
US4347198A (en) * | 1977-09-12 | 1982-08-31 | Toray Industries, Ltd. | Producing soft contact lenses |
US4224427A (en) * | 1978-06-01 | 1980-09-23 | Ciba-Geigy Corporation | Process for preparing hydrogels as spherical beads of large size |
Non-Patent Citations (4)
Title |
---|
Runge et al., Radiology, vol. 147, pp. 789 791 (1983). * |
Runge et al., Radiology, vol. 147, pp. 789-791 (1983). |
Wehrli et al, Magnetic Resonance Imaging, vol. 2, pp. 3 16 (1984). * |
Wehrli et al, Magnetic Resonance Imaging, vol. 2, pp. 3-16 (1984). |
Cited By (77)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5023185A (en) * | 1986-12-17 | 1991-06-11 | Nippon Oil Co., Ltd. | Method for determining resolution power or discrimination capacity of an NMR imaging apparatus |
US5079006A (en) * | 1987-07-15 | 1992-01-07 | Aprex Corporation | Pharmaceutical compositions containing a magnetically detectable material |
US5071602A (en) * | 1987-08-27 | 1991-12-10 | Nippon Oil Co., Ltd. | Method of making phantom for nmr diagnosis |
US5045304A (en) * | 1988-08-31 | 1991-09-03 | Wayne State University | Contras agent having an imaging agent coupled to viable granulocytes for use in magnetic resonance imaging of abscess and a method of preparing and using same |
US5145661A (en) * | 1988-08-31 | 1992-09-08 | Wayne State University | Method and contrast agent for use in magnetic resonance imaging of abscess |
US5125408A (en) * | 1988-10-24 | 1992-06-30 | The United States Of America As Represented By The Of The Department Of Health And Human Services | Pressure sensor element and method to measure contact stress |
US4967764A (en) * | 1988-10-24 | 1990-11-06 | The United States Of America As Represented By The Department Of Health And Human Services | Pressure sensor element to measure contact stress |
US5312755A (en) * | 1989-02-24 | 1994-05-17 | Wisconsin Alumni Research Foundation | Contrast resolution tissue mimicking phantoms for nuclear magnetic resonance imaging with stable NMR properties |
JP2962521B2 (en) | 1989-07-21 | 1999-10-12 | ニユコメド・アクシエセルカペト | Contrast composition |
EP0409351A1 (en) * | 1989-07-21 | 1991-01-23 | Nycomed Imaging As | Contrast medium composition |
US5393525A (en) * | 1989-07-21 | 1995-02-28 | Nycomed Imaging As | Contrast medium comprising superparamagnetic or ferromagnetic particles capable of increasing viscosity after administration |
JPH04506806A (en) * | 1989-07-21 | 1992-11-26 | ニユコメド・アクシエセルカペト | Contrast agent composition |
US5380514A (en) * | 1990-03-24 | 1995-01-10 | The Victoria University Of Manchester | Method for magnetic resonance imaging of internal body tissues using polysiloxanes |
US5624661A (en) * | 1990-04-10 | 1997-04-29 | Unger; Evan C. | Hypoosmotic compositions comprising a polymer and a complexed contrast agent for MRI |
EP0693288A1 (en) * | 1990-04-10 | 1996-01-24 | UNGER, Evan C | Polymers as contrast media for magnetic resonance |
US5985244A (en) * | 1990-04-10 | 1999-11-16 | Imarx Pharmaceutical Corp. | Polymers with a gas magnetic resonance imaging |
US5368840A (en) * | 1990-04-10 | 1994-11-29 | Imarx Pharmaceutical Corp. | Natural polymers as contrast media for magnetic resonance imaging |
WO1991015753A1 (en) * | 1990-04-10 | 1991-10-17 | Unger Evan C | Polymers as contrast media for magnetic resonance imaging |
US5681542A (en) * | 1990-04-10 | 1997-10-28 | Imarx Pharmaceutical Corp. | Compositions comprising a biocompatible gas and a polymer for magnetic resonance imaging |
US5658550A (en) * | 1990-04-10 | 1997-08-19 | Imarx Pharmaceutical Corp. | Non cross-linked synthetic polymers as contrast media for magnetic resonance imaging |
US5645816A (en) * | 1990-04-10 | 1997-07-08 | Imarx Pharmaceutical Corp. | Synthetic polyuronic and hypoosmotic polymer compositions in admixture with proteinaceously bound contrast agents for MRI |
US5688490A (en) * | 1991-02-15 | 1997-11-18 | Bracco International B.V. | Mucoadhesive compositions for increasing the ultrasonic image contrast of the digestive tract |
EP0502814A2 (en) * | 1991-02-15 | 1992-09-09 | BRACCO International B.V. | Compositions for increasing the image contrast in imaging of the digestive tract of patients |
US5370901A (en) * | 1991-02-15 | 1994-12-06 | Bracco International B.V. | Compositions for increasing the image contrast in diagnostic investigations of the digestive tract of patients |
US5792445A (en) * | 1991-02-15 | 1998-08-11 | Bracco International B.V. | Polymers and copolymers of acrylic acid MRI of the digestive tract of patients |
US5653959A (en) * | 1991-02-15 | 1997-08-05 | Sintetica Sa | Compositions for increasing the image contrast in diagnostic investigations of the digestive tract of patients |
EP0502814A3 (en) * | 1991-02-15 | 1992-10-07 | Sintetica S.A. | Compositions for increasing the image contrast in diagnostic investigations of the digestive tract of patients |
US5385719A (en) * | 1991-09-24 | 1995-01-31 | Unger; Evan C. | Copolymers and their use as contrast agents in magnetic resonance imaging and in other applications |
US5458127A (en) * | 1991-09-24 | 1995-10-17 | Imarx Pharmaceutical Corp. | Copolymers and their use as contrast agents in magnetic resonance imaging and in other applications |
US5517993A (en) * | 1991-09-24 | 1996-05-21 | Imarx Pharmaceutical Corp. | Copolymers and their use as contrast agents in magnetic resonance imaging and in other applications |
WO1993010163A2 (en) * | 1991-11-12 | 1993-05-27 | Nepera, Inc. | Adhesive hydrogels having extended use lives and process for the preparation of same |
WO1993010163A3 (en) * | 1991-11-12 | 1993-06-24 | Nepera Inc | Adhesive hydrogels having extended use lives and process for the preparation of same |
AU671862B2 (en) * | 1992-10-13 | 1996-09-12 | Imarx Therapeutics, Inc. | Polymers as contrast media for magnetic resonance imaging |
WO1994008509A1 (en) * | 1992-10-13 | 1994-04-28 | Unger Evan C | Polymers as contrast media for magnetic resonance imaging |
US5551429A (en) * | 1993-02-12 | 1996-09-03 | Fitzpatrick; J. Michael | Method for relating the data of an image space to physical space |
US5730130A (en) * | 1993-02-12 | 1998-03-24 | Johnson & Johnson Professional, Inc. | Localization cap for fiducial markers |
US5532006A (en) * | 1993-04-23 | 1996-07-02 | The Board Of Trustees Of The University Of Illinois | Magnetic gels which change volume in response to voltage changes for MRI |
US6333971B2 (en) | 1995-06-07 | 2001-12-25 | George S. Allen | Fiducial marker |
US6675035B1 (en) | 1997-06-20 | 2004-01-06 | Imaging Diagnostic Systems, Inc. | Phantom for optical and magnetic resonance imaging quality control |
US6410616B1 (en) * | 1998-04-09 | 2002-06-25 | Nippon Shokubai Co., Ltd | Crosslinked polymer particle and its production process and use |
US6635486B2 (en) | 1999-07-14 | 2003-10-21 | Wisconsin Alumni Research Foundation | Multi-imaging modality tissue mimicking materials for imaging phantoms |
US6318146B1 (en) * | 1999-07-14 | 2001-11-20 | Wisconsin Alumni Research Foundation | Multi-imaging modality tissue mimicking materials for imaging phantoms |
US20070167735A1 (en) * | 2001-11-27 | 2007-07-19 | Sheng-Ping Zhong | Implantable or insertable medical devices visible under magnetic resonance imaging |
US20030100830A1 (en) * | 2001-11-27 | 2003-05-29 | Sheng-Ping Zhong | Implantable or insertable medical devices visible under magnetic resonance imaging |
US8163326B2 (en) * | 2001-11-27 | 2012-04-24 | Boston Scientific Scimed, Inc. | Implantable or insertable medical devices visible under magnetic resonance imaging |
US20050227364A1 (en) * | 2002-10-04 | 2005-10-13 | Wisconsin Alumni Research Foundation | Tissue mimicking elastography phantoms |
US20040067591A1 (en) * | 2002-10-04 | 2004-04-08 | Wisconsin Alumni Research Foundation | Tissue mimicking elastography phantoms |
US7462488B2 (en) | 2002-10-04 | 2008-12-09 | Wisconsin Alumni Research Foundation | Tissue mimicking elastography phantoms |
US6965235B1 (en) | 2003-07-24 | 2005-11-15 | General Electric Company | Apparatus to simulate MR properties of human brain for MR applications evaluation |
JP2005104842A (en) * | 2003-09-26 | 2005-04-21 | Mitsui Chemicals Inc | New (meth)acrylate having thiourethane skeleton |
US20080077006A1 (en) * | 2004-08-25 | 2008-03-27 | Koninklijke Philips Electronics, N.V. | Mr Method of Determining Local Relaxation Time Values Using Calibrated Phantom |
US7642775B2 (en) | 2004-08-25 | 2010-01-05 | Koninklijke Philips Electronics N.V. | MR method of determining local relaxation time values using calibrated phantom |
US7419376B2 (en) * | 2006-08-14 | 2008-09-02 | Artahn Laboratories, Inc. | Human tissue phantoms and methods for manufacturing thereof |
WO2008021720A3 (en) * | 2006-08-14 | 2008-12-04 | Artann Lab Inc | Human tissue phantoms and methods for manufacturing thereof |
US20080076099A1 (en) * | 2006-08-14 | 2008-03-27 | Artann Laboratories, Inc. | Human tissue phantoms and methods for manufacturing thereof |
WO2008021720A2 (en) * | 2006-08-14 | 2008-02-21 | Artann Laboratories, Inc. | Human tissue phantoms and methods for manufacturing thereof |
US20130022548A1 (en) * | 2009-12-14 | 2013-01-24 | Bennett Kevin M | Methods and Compositions Relating to Reporter Gels for Use in MRI Techniques |
US9823325B2 (en) * | 2009-12-14 | 2017-11-21 | Kevin M. Bennett | Methods and compositions relating to reporter gels for use in MRI techniques |
US20140356967A1 (en) * | 2011-12-28 | 2014-12-04 | Hitachi, Ltd. | Tissue mimicking phantom and calibration device |
US9958521B2 (en) | 2015-07-07 | 2018-05-01 | Q Bio, Inc. | Field-invariant quantitative magnetic-resonance signatures |
US10194829B2 (en) | 2015-07-07 | 2019-02-05 | Q Bio, Inc. | Fast scanning based on magnetic resonance history |
US10635833B2 (en) | 2015-09-12 | 2020-04-28 | Q Bio, Inc. | Uniform-frequency records with obscured context |
US10964412B2 (en) | 2015-10-20 | 2021-03-30 | Q Bio, Inc. | Population-based medical rules via anonymous sharing |
WO2017161239A1 (en) * | 2016-03-18 | 2017-09-21 | Q Bio, Inc. | System and method for magnetic resonance elastography |
US11872025B2 (en) | 2016-03-18 | 2024-01-16 | Q Bio, Inc. | System and method for magnetic resonance elastography |
US10359486B2 (en) | 2016-04-03 | 2019-07-23 | Q Bio, Inc. | Rapid determination of a relaxation time |
US10222441B2 (en) | 2016-04-03 | 2019-03-05 | Q Bio, Inc. | Tensor field mapping |
US11085984B2 (en) | 2016-04-03 | 2021-08-10 | Q Bio, Inc. | Tensor field mapping |
US11650195B2 (en) | 2017-02-03 | 2023-05-16 | Q Bio, Inc. | Iterative medical testing of biological samples |
US10936180B2 (en) | 2017-03-16 | 2021-03-02 | Q Bio, Inc. | User interface for medical information |
US11354586B2 (en) | 2019-02-15 | 2022-06-07 | Q Bio, Inc. | Model parameter determination using a predictive model |
US11360166B2 (en) | 2019-02-15 | 2022-06-14 | Q Bio, Inc | Tensor field mapping with magnetostatic constraint |
US11748642B2 (en) | 2019-02-15 | 2023-09-05 | Q Bio, Inc. | Model parameter determination using a predictive model |
US11614509B2 (en) | 2019-09-27 | 2023-03-28 | Q Bio, Inc. | Maxwell parallel imaging |
US11131735B2 (en) | 2019-09-27 | 2021-09-28 | Q Bio, Inc. | Maxwell parallel imaging |
US11181601B1 (en) | 2020-05-19 | 2021-11-23 | Wisconsin Alumni Research Foundation | Systems and methods for magnetic resonance phantoms |
US11614508B1 (en) | 2021-10-25 | 2023-03-28 | Q Bio, Inc. | Sparse representation of measurements |
Also Published As
Publication number | Publication date |
---|---|
CA1279819C (en) | 1991-02-05 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
US4729892A (en) | Use of cross-linked hydrogel materials as image contrast agents in proton nuclear magnetic resonance tomography and tissue phantom kits containing such materials | |
US11857694B2 (en) | Particles | |
EP0777503B1 (en) | Radiopaque polymers and methods for preparation thereof | |
US5236969A (en) | Polymer compositions for contact lenses | |
Hagit et al. | Synthesis and characterization of dual modality (CT/MRI) core− shell microparticles for embolization purposes | |
Horak et al. | Hydrogels in endovascular embolization. III. Radiopaque spherical particles, their preparation and properties | |
AU2003288178A1 (en) | Stabilization of poly(oxyalkylene) contining polymeric materials | |
JPH08509141A (en) | Medical devices and materials that enhance the visibility of magnetic images | |
JP2002506690A (en) | Methods for producing intraocular lenses and materials suitable for their production | |
EP1031354A2 (en) | Polymeric MRI Contrast agents | |
US4622367A (en) | X-ray contrast spherical hydrogel particles based on polymer and copolymers of acrylates and methacrylates and the method for preparation thereof | |
Le et al. | Crosslinkable polymeric contrast agent for high-resolution X-ray imaging of the vascular system | |
Okamura et al. | Synthesis and properties of radiopaque polymer hydrogels II: copolymers of 2, 4, 6-triiodophenyl-or N-(3-carboxy-2, 4, 6-triiodophenyl)-acrylamide and p-styrene sulfonate | |
EP0488200B1 (en) | Sheet for assisting in NMR diagnosis | |
EP2214718A1 (en) | Loadable polymeric particles for enhanced imaging in clinical applications and methods of preparing and using the same | |
CN117618631A (en) | Developing embolism microsphere and preparation method thereof | |
DE2502682C2 (en) | Hydrophilic and water absorbable copolymer | |
JPH03103237A (en) | Phantom for adjusting crossing-over relaxation time mri | |
CN1686571A (en) | Magnetic resonance radiography reinforcing coating composition used for interposing catheter or device and its preparation method | |
JP2021085016A (en) | pH-RESPONSIVE POLYMER COMPOUND |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
AS | Assignment |
Owner name: CIBA-GEIGY CORPORATION, 444 SAW MILL RIVER ROAD, A Free format text: ASSIGNMENT OF ASSIGNORS INTEREST.;ASSIGNOR:BEALL, PAULA T.;REEL/FRAME:004797/0507 Effective date: 19860321 Owner name: CIBA-GEIGY CORPORATION, 444 SAW MILL RIVER ROAD, A Free format text: ASSIGNMENT OF ASSIGNORS INTEREST;ASSIGNOR:BEALL, PAULA T.;REEL/FRAME:004797/0507 Effective date: 19860321 |
|
STCF | Information on status: patent grant |
Free format text: PATENTED CASE |
|
FEPP | Fee payment procedure |
Free format text: PAYOR NUMBER ASSIGNED (ORIGINAL EVENT CODE: ASPN); ENTITY STATUS OF PATENT OWNER: LARGE ENTITY |
|
FPAY | Fee payment |
Year of fee payment: 4 |
|
FPAY | Fee payment |
Year of fee payment: 8 |
|
FPAY | Fee payment |
Year of fee payment: 12 |
|
AS | Assignment |
Owner name: NOVARTIS CORPORATION, NEW YORK Free format text: CHANGE OF NAME;ASSIGNOR:CIBA-GEIGY CORPORATION;REEL/FRAME:011089/0648 Effective date: 19970612 |