US4789639A - Liquid recovery device - Google Patents
Liquid recovery device Download PDFInfo
- Publication number
- US4789639A US4789639A US07/000,058 US5887A US4789639A US 4789639 A US4789639 A US 4789639A US 5887 A US5887 A US 5887A US 4789639 A US4789639 A US 4789639A
- Authority
- US
- United States
- Prior art keywords
- receptacle
- pad
- liquid
- shaft
- sleeve
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
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Images
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B10/00—Other methods or instruments for diagnosis, e.g. instruments for taking a cell sample, for biopsy, for vaccination diagnosis; Sex determination; Ovulation-period determination; Throat striking implements
- A61B10/0096—Casings for storing test samples
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
- C12M23/00—Constructional details, e.g. recesses, hinges
- C12M23/32—Frangible parts
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
- C12M33/00—Means for introduction, transport, positioning, extraction, harvesting, peeling or sampling of biological material in or from the apparatus
- C12M33/02—Means for introduction, transport, positioning, extraction, harvesting, peeling or sampling of biological material in or from the apparatus by impregnation, e.g. using swabs or loops
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S436/00—Chemistry: analytical and immunological testing
- Y10S436/807—Apparatus included in process claim, e.g. physical support structures
- Y10S436/81—Tube, bottle, or dipstick
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
- Y10T436/00—Chemistry: analytical and immunological testing
- Y10T436/25—Chemistry: analytical and immunological testing including sample preparation
- Y10T436/25375—Liberation or purification of sample or separation of material from a sample [e.g., filtering, centrifuging, etc.]
- Y10T436/255—Liberation or purification of sample or separation of material from a sample [e.g., filtering, centrifuging, etc.] including use of a solid sorbent, semipermeable membrane, or liquid extraction
Definitions
- the present invention relates to preparation of solutions for analysis, and more particularly, related to a device and method for recovery of a solution from an absorbent material.
- Immunoassay is conventionally carried out by contacting in an assay vehicle a solution of an analyte, such as an antigen, antibody or hapten, with a specific antianalyte.
- an analyte such as an antigen, antibody or hapten
- the sensitivity of the assay is often at least in part determined by the concentration of the analyte in the assay vehicle, and, in general, it is advantageous to carry out the assay on as concentrated a solution of analyte as possible.
- identification of the pathogen is often necessary in order to determine the most effective treatment. Frequently this entails taking a culture sample, by swabbing the patient's throat or nasal passage, immersing the swab in an appropriate liquid in a receptacle to give a solution of an antigen associated with the pathogen, and performing an immunoassay on the solution.
- Use of too much liquid for immersion of the swab reduces the antigen concentration in the solution.
- use of too little liquid results in absorption of a substantial portion of the solution into the swab so that insufficient solution remains in the receptacle to perform the assay.
- a variety of related devices has been disclosed for collecting, maintaining and transporting culture specimens to be taken by swab.
- these devices include a swab and a receptacle containing a liquid to keep the specimen viable during transport, and may also include structure to protect a technician from coming into contact with the specimen at any time during use of the device.
- Representative of such devices are those disclosed in U.S. Pat. No. 3,674,007 to Freis and U.S. Pat. No. 3,776,220 to Monaghan.
- the liquid is provided in a separate frangible container.
- U.S. Pat. No. 4,175,008 to White additionally provides a long swab stem for ease of specimen taking which includes a breakaway feature for use with a short compact receptacle to facilitate sample transport.
- a liquid recovery device includes a receptacle, a sample transfer means and a wringing means.
- the transfer means and wringing means are both positioned inside the receptacle, the transfer means below the wringing means.
- the preferred receptacle has a body portion, a closed lower end, an open upper end and may additionally have means for removably attaching a cap.
- the preferred transfer means is a shaft having an absorbent material attached to one end of a shaft.
- the most preferred receptacle and transfer means are a vial and a swab consisting of a shaft and an absorbent pad.
- the wringing means may be any structure adapted to compress the absorbent transfer material and thereby cause removal of a liquid absorbed therein.
- the wringing means is a cap for the receptacle having a hole large enough to allow the shaft to pass through, but small enough so that the absorbent material is compressed when it passes through.
- a flat rubber plug in the cap has a cross slit to facilitate the wringing when the transfer means passes through.
- the wringing means is a closure inserted into the open upper end of the receptacle. The closure has a passageway therethrough which is dimensioned to compress the absorbent material when it enters the passageway.
- the wringing means is a sleeve supported within the receptacle. Both ends of the sleeve are open and have closures inserted therein. The closures have aligned passageways through which the shaft passes. The passageways are large enough so that the shaft may be passed through, but small enough so that the absorbent pad is compressed when it enters the passageway in the lower closure.
- the cap and wringing means may be an integral unit which includes a sleeve having integrally formed base and head portions with holes therein for the shaft and means such as threads for removable attachment of the integral wringing unit to the receptacle.
- the device may be used in a method for recovering a liquid from an absorbent material.
- the device is useful in preparing a sample of an analyte in a small volume of liquid to be used in assaying for the analyte.
- a swab may be used to take a throat or nasal sample suspected of containing an analyte, such as a microorganism or a virus.
- the absorbent pad of the swab, having the analyte sample thereon is mixed thoroughly with a liquid in the receptacle whereby a portion of the liquid is absorbed into the pad.
- the swab shaft is pulled upward, the pad enters the hole in the lower closure and is compressed whereby the liquid containing the analyte is squeezed out and collects in the receptacle.
- the device of the invention overcomes deficiencies of prior art devices used to collect swab samples and prepare solutions of the samples in a liquid for immunoassay, and, when used in the method of the invention, increases the sensitivity of the immunoassay.
- Prior art devices make no provision for recovery of the substantial volume of liquid absorbed and retained by the swab.
- a larger volume of liquid must be used in prior devices in order to obtain sufficient volumes of solution to carry out the assay.
- the larger volume reduces the analyte concentration in the solution.
- the device of the present invention allows recovery of most of the solution which otherwise would be retained by the swab. Smaller volumes of liquid can thus be used, higher concentrations of analyte obtained and more sensitive assays achieved.
- the swab is enclosed in the sleeve thereby providing for safe and sanitary disposal of the used web.
- FIG. 1 is perspective view of the liquid recovery device of the invention
- FIG. 2 is a perspective view of a preferred embodiment of the receptacle of the recovery device of FIG. 1;
- FIG. 3 is a perspective view of the preferred sample transfer unit of the recovery device of FIG. 1;
- FIG. 4 is a perspective view of a preferred wringing unit of the recovery device of FIG. 1;
- FIG. 5 is a vertical sectional view of the wringing unit of FIG. 4 taken along the line 5--5 thereof;
- FIGS. 6 is a vertical sectional view of the liquid recovery device of FIG. 1 taken along the line 6--6 thereof;
- FIGS. 7 and 8 are sectional views similar to FIG. 6 illustrating the sequential steps of removing the swab from the liquid and wringing it;
- FIG. 9 is a partial vertical sectional view of another embodiment of the recovery device showing an alternative wringing unit
- FIG. 10 is a perspective view of an alternative embodiment of the wringing unit
- FIG. 11 is a vertical sectional view of the wringing unit of FIG. 10 taken along the line 11--11 thereof;
- FIG. 12 is a vertical sectional view of a further embodiment of the device showing an integral cap and wringing unit
- FIGS. 13 and 14 are partial vertical sectional views of alternate embodiments of the recovery device of the present invention.
- the liquid recovery device of the invention comprises a receptacle, a sample transfer unit and a liquid wringing unit.
- FIG. 1 shows liquid recovery device 15 having a receptacle 16, a cap 17 and a shaft 18 of the sample transfer unit passing through a hole 19 in cap 17.
- Receptacle 16 has an open upper end and a closed lower end, and in FIG. 2, is depicted as a vial 20 having a closed bottom end 22, an open upper end 24, and a body portion 26.
- a neck portion 28 of body portion 26 has an upper lip 29 and a thread 30 for removable attachment of cap 17.
- the preferred sample transfer unit is a swab 32 having an absorbent pad 34 attached to one end of the shaft 18, as illustrated in FIG. 3.
- Pad 34 may be attached to shaft 18 in any convenient way provided that the attachment is sufficiently secure to prevent detachment of the pad from the shaft when upward movement (as described below) is appled to shaft 18 and pad 34 is thereby pulled into the wringing unit.
- a physical means of attachment such as twisting may be used, or, preferably, a permanent bonding method, such as gluing, may be used.
- FIGS. 4 and 5 A preferred embodiment of the wringing unit 36 is illustrated in FIGS. 4 and 5.
- a sleeve 38 has an open lower end 39 and an open upper end 40.
- a closure 42 in open lower end 39 has a passageway 44 therethrough.
- a closure 46 in open upper end 40 has a passageway 48 therethrough and a flange 50.
- Flange 50 is dimensioned so that its lower edge 52 rests on lip 29 of vial 20, as described below.
- FIG. 6 shows the relationship of the receptacle, transfer unit and wringing unit in the assembled liquid recovery device of the invention.
- Absorbent pad 34 attached to shaft 18 is immersed in a reservoir of a liquid 53 in vial 20.
- Shaft 18 extends through passageways 44 and 48 of closures 42 and 46 respectively.
- a washer 54 rests on lip 29 of vial neck portion 28 and provides rigidity to support flange 50.
- Cap 17 has an internal thread 55 which mates with thread 30 of vial neck portion 28.
- Pad 34 when withdrawn from liquid 53 by upward movement applied to shaft 18, retains a portion of the liquid due to its absorbent nature.
- FIG. 7 shows pad 34 entering passageway 44 of lower closure 42. It is seen that passageway 44 is large enough to allow passage of shaft 18 but too small to allow free passage of pad 34. Pad 34 is thereby compressed when in passageway 44 and liquid 53a, retained in the pad, is squeezed out and drips back into the reservoir of liquid 53 in vial 20.
- Cap 17 may then be detached from vial 20 by unscrewing threads 30 and 55 and the complete wringing and transfer units including sleeve 38, closure 42 and 46 and shaft 18 with attached pad 34 removed and discarded. Cap 17 may then be replaced, or, preferably, a modified cap (not shown in the figures) identical to 17 in all respects except lacking hole 19, may be used. It is seen that, after removal of the transfer and wringing units and attachment of the modified cap, a sealed vial containing liquid 53 is obtained which is suitable for immediate assay or for storage or transfer. It is further seen that pad 34 is substantially enclosed by sleeve 38 and closures 42 and 46 thereby providing the important advantage of safe and sanitary disposal of the used swab.
- Sleeve 38 described with respect to the preferred embodiment, may be eliminated and closure 46a placed directly in open end 24a of vial 20a, as shown in FIG. 9. It is seen that wringing will occur when upward movement is applied to shaft 18a so that pad 34a enters passageway 48a.
- FIGS. 10 and 11 show wringing unit 60 as an integrally formed unit consisting of sleeve 38a, base portion 62 defining passageway 64 and top portion 66 defining passageway 68.
- Top portion 66 includes flange 69.
- Unit 70 has a jacket 71 having a wall portion 72, a base portion 73 and a head portion 74. Head portion 74 rests on and is supported by receptacle lip 29b and defines passageway 75. Base portion 73 defines passageway 76. Shaft 18b slides freely in the passageways. Absorbent pad 34b, when withdrawn from liquid 53 and drawn through passageway 76, is compressed to induce wringing, as described above. Head portion 74 and neck portion 28b of vial 20b have means, illustrated in FIG. 12 as mating threads 30b and 77, for removably attaching the head portion 74 to the vial.
- FIG. 13 shows this embodiment of the device to have an optional flat washer 84 with hole 86 on either or both sides of disc 80 to provide rigidity for prevention of distortion of the disc when pad 34d is drawn through cross slits 82d.
- liquid recovery device of the invention has been illustrated with threads for attachment of the cap to the vial. It is evident that other means, such as compression or snap fits may be used instead of screw fits.
- vial 20 and sleeve 38 may be glass or any suitable plastic, preferably transparent, such as polyolefin, polyurethane and the like.
- Cap 17 and washer 54 preferably are plastic.
- Pad 34 may be of any suitable absorbent material, such as glass wool, cotton, rayon, nylon, dacron and the like.
- Shaft 18 may be plastic or, preferably wood.
- Closures 42 and 46 and disc 80 may be plastic, preferably rubber.
- Vial 20 may contain a reagent, preferably soluble and in lyophilized form, to be reconstituted in liquid 53 when the device is to be used.
- the reagent may be for any purpose.
- the reagent may provide a medium to promote growth or maintain the viability of a microorganism, or it may provide a medium for breakdown of material transferred by swab 32 into a form which can more readily be assayed.
- reagents may be supplied which, when reconstituted in liquid 53, provide a buffer suitable for storing or transporting a material prior to assay.
- any suitable liquid may be added to vial 20 in accordance with the purpose for which the device is to be used. Water or, if desired, an organic solvent may be added. When the device is to be used for immunoassay of an antigen, water, saline, or buffer, and the like may be added.
- the volume of liquid to be added to the vial may in general be determined by the use contemplated for the device. Immunoassay procedures in general require from about 5 to 1000 ul of assay solution. Conventional medical swabs retain about 300 ul of liquid, about 200 ul of which may be recovered when the swab is used in conjunction with the device of the invention. Thus, for an assay procedure requiring about 200 ul of antigen solution, only about 300 ul of liquid need be added to the receptacle. On the other hand, conventional preparation of the antigen solution (i.e., without the recovery device of the invention), may require 500 or more ul of liquid to obtain 200 ul of usable antigen solution. Thus, it is seen that the device of the invention provides 40 percent or more increase in antigen concentration in the assay solution and thereby a substantial increase in assay sensitivity.
Abstract
Description
Claims (14)
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
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US07/000,058 US4789639A (en) | 1987-01-02 | 1987-01-02 | Liquid recovery device |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
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US07/000,058 US4789639A (en) | 1987-01-02 | 1987-01-02 | Liquid recovery device |
Publications (1)
Publication Number | Publication Date |
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US4789639A true US4789639A (en) | 1988-12-06 |
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ID=21689719
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
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US07/000,058 Expired - Fee Related US4789639A (en) | 1987-01-02 | 1987-01-02 | Liquid recovery device |
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Cited By (39)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4963325A (en) * | 1988-05-06 | 1990-10-16 | Hygeia Sciences, Inc. | Swab expressor immunoassay device |
US5096062A (en) * | 1990-07-10 | 1992-03-17 | Hoffmann-La Roche Inc. | Transport system for shipping microbiological samples |
US5102631A (en) * | 1989-12-18 | 1992-04-07 | Abbott Laboratories | Evaporation chimney |
US5260031A (en) * | 1990-12-18 | 1993-11-09 | Saliva Diagnostic Systems, Inc. | Saliva sampling device with sample adequacy indicating system |
WO1995000244A1 (en) * | 1993-06-25 | 1995-01-05 | National Scientific Company | Screw thread autosampler vial and closure for use with laboratory robotics |
US5460781A (en) * | 1989-10-27 | 1995-10-24 | Fujirebio Kabushiki Kaisha | Hemoglobin sampler |
US5514339A (en) * | 1989-04-07 | 1996-05-07 | Leopardi; Francesco | Stopper of analysis test tubes |
US5916526A (en) * | 1995-08-11 | 1999-06-29 | Robbins Scientific Corporation | Compartmentalized multi-well container |
US6173851B1 (en) * | 1999-03-18 | 2001-01-16 | Anesta Corporation | Method and apparatus for the interim storage of medicated oral dosage forms |
US6372313B1 (en) | 1998-09-01 | 2002-04-16 | Closure Medical Corporation | Package assembly with applicator and container for adhesive materials |
US20020127147A1 (en) * | 2001-03-09 | 2002-09-12 | Kacian Daniel L. | Penetrable cap |
US20020197196A1 (en) * | 2001-05-15 | 2002-12-26 | Brian Hague | Method and system for disposing of a medicated oral dosage form |
US20020197738A1 (en) * | 2001-06-21 | 2002-12-26 | Gc Corporation | Pretreatment instrument of saliva and pretreatment method of saliva |
US6548309B1 (en) * | 1998-03-19 | 2003-04-15 | Binax, Inc. | Procedure for assay of liquids containing undissolved solids, semisolids or colloids |
US6558630B1 (en) * | 1997-10-20 | 2003-05-06 | Hans Degn | Dosing unit and a method of continuous introduction of liquid solution samples into a system |
US6716396B1 (en) | 1999-05-14 | 2004-04-06 | Gen-Probe Incorporated | Penetrable cap |
US6802416B1 (en) | 1998-09-01 | 2004-10-12 | Closure Medical Corporation | Package assembly with applicator and container for adhesive materials |
US20040214316A1 (en) * | 2003-04-24 | 2004-10-28 | O'connell David | Personal cell sampling kit |
US20040267181A1 (en) * | 2003-06-26 | 2004-12-30 | Asd | Swab sample collection and recovery device |
US20050010133A1 (en) * | 2003-07-08 | 2005-01-13 | Larry Pestes | Specimen collection system |
US20050023182A1 (en) * | 2003-08-01 | 2005-02-03 | Shah Tilak M. | Press-flat centrifuge tube and specimen collection assembly comprising same |
US20050155440A1 (en) * | 2004-01-16 | 2005-07-21 | Andx, Inc. | Sample collection device and method |
US20050167391A1 (en) * | 2003-03-03 | 2005-08-04 | Aqua Pyrenees S.A. | Stopper device for containers, such as cylinders, equipped with a neck of the water fountain type |
US20080103426A1 (en) * | 2006-10-25 | 2008-05-01 | Cao Group, Inc. | Unit Dose Delivery Systems Using Brushes |
US20080268427A1 (en) * | 2001-08-09 | 2008-10-30 | Idexx Laboratories, Inc. | Detection of bovine viral diarrhea virus in hair samples |
US20090042182A1 (en) * | 2001-08-09 | 2009-02-12 | Idexx Laboratories, Inc. | Detection of bovine viral diarrhea virus in tissue samples |
US20090202288A1 (en) * | 2008-02-07 | 2009-08-13 | Koschinsky Ralph K | Dispenser of coating material |
US20090246750A1 (en) * | 2004-04-09 | 2009-10-01 | Research Think Tank, Inc. | Devices and Methods for Collection, Storage and Transportation of Biological Specimens |
US20110085948A1 (en) * | 2009-10-12 | 2011-04-14 | Poll Val L | Devices and methods for collecting and processing a specimen |
US20110083495A1 (en) * | 2009-10-12 | 2011-04-14 | Poll Val L | Devices and methods for collecting and processing a specimen |
EP2502982A1 (en) | 2011-03-22 | 2012-09-26 | Qiagen GmbH | Device for recovery of a collected specimen |
EP2510881A1 (en) | 2011-04-11 | 2012-10-17 | Qiagen GmbH | Device and method for recovery of a collected specimen |
US8623665B2 (en) | 2009-10-12 | 2014-01-07 | Val L. Poll | Fecal sample collection and processing apparatus and method |
DE102013013003A1 (en) * | 2013-08-02 | 2015-02-19 | Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V. | Apparatus and method for detaching biological material from a surface of a carrier |
USD743046S1 (en) | 2009-10-12 | 2015-11-10 | Medsmart, Llc | Fecal sample collection device |
US20160273059A1 (en) * | 2013-10-22 | 2016-09-22 | Ilex Medical Ltd. | Kit and method for collecting body fluid for medical diagnosis |
US10092275B2 (en) | 2011-01-05 | 2018-10-09 | Copan Italia S.P.A. | Process for realising a device for collecting and transferring samples for molecular biology |
US10327741B2 (en) | 2003-04-01 | 2019-06-25 | Copan Italia S.P.A. | Swab for collecting biological specimens |
JP2021167822A (en) * | 2015-07-24 | 2021-10-21 | ノベル マイクロデバイシズ, エルエルシー (ディービーエー ノベル デバイシズ)Novel Microdevices, Llc (Dba Novel Devices) | Sample extraction device and method of use thereof |
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Cited By (79)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4963325A (en) * | 1988-05-06 | 1990-10-16 | Hygeia Sciences, Inc. | Swab expressor immunoassay device |
US5514339A (en) * | 1989-04-07 | 1996-05-07 | Leopardi; Francesco | Stopper of analysis test tubes |
US5460781A (en) * | 1989-10-27 | 1995-10-24 | Fujirebio Kabushiki Kaisha | Hemoglobin sampler |
US5102631A (en) * | 1989-12-18 | 1992-04-07 | Abbott Laboratories | Evaporation chimney |
US5096062A (en) * | 1990-07-10 | 1992-03-17 | Hoffmann-La Roche Inc. | Transport system for shipping microbiological samples |
US5283038A (en) * | 1990-12-18 | 1994-02-01 | Saliva Diagnostic Systems, Inc. | Fluid sampling and testing device |
US5260031A (en) * | 1990-12-18 | 1993-11-09 | Saliva Diagnostic Systems, Inc. | Saliva sampling device with sample adequacy indicating system |
WO1995000244A1 (en) * | 1993-06-25 | 1995-01-05 | National Scientific Company | Screw thread autosampler vial and closure for use with laboratory robotics |
US5916526A (en) * | 1995-08-11 | 1999-06-29 | Robbins Scientific Corporation | Compartmentalized multi-well container |
US6558630B1 (en) * | 1997-10-20 | 2003-05-06 | Hans Degn | Dosing unit and a method of continuous introduction of liquid solution samples into a system |
US6548309B1 (en) * | 1998-03-19 | 2003-04-15 | Binax, Inc. | Procedure for assay of liquids containing undissolved solids, semisolids or colloids |
US20040026282A1 (en) * | 1998-09-01 | 2004-02-12 | Closure Medical Corporation | Package assembly with applicator and container for adhesive materials |
US6372313B1 (en) | 1998-09-01 | 2002-04-16 | Closure Medical Corporation | Package assembly with applicator and container for adhesive materials |
US6960040B2 (en) | 1998-09-01 | 2005-11-01 | Closure Medical Corporation | Package assembly with applicator and container for adhesive materials |
US6802416B1 (en) | 1998-09-01 | 2004-10-12 | Closure Medical Corporation | Package assembly with applicator and container for adhesive materials |
US6173851B1 (en) * | 1999-03-18 | 2001-01-16 | Anesta Corporation | Method and apparatus for the interim storage of medicated oral dosage forms |
US6286698B2 (en) * | 1999-03-18 | 2001-09-11 | Cephalon, Inc. | Methods and apparatus for the interim storage of medicated oral dosage forms |
US8211710B2 (en) | 1999-05-14 | 2012-07-03 | Dickey Kathleen A | Method for accessing the contents of a closed collection device |
US7276383B2 (en) | 1999-05-14 | 2007-10-02 | Gen-Probe Incorporated | Method for obtaining the contents of a fluid-holding vessel |
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