US4976259A - Ultrasonic nebulizer - Google Patents
Ultrasonic nebulizer Download PDFInfo
- Publication number
- US4976259A US4976259A US07/266,823 US26682388A US4976259A US 4976259 A US4976259 A US 4976259A US 26682388 A US26682388 A US 26682388A US 4976259 A US4976259 A US 4976259A
- Authority
- US
- United States
- Prior art keywords
- crystal
- transducer
- interface
- cover member
- fluid reservoir
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
Images
Classifications
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B05—SPRAYING OR ATOMISING IN GENERAL; APPLYING FLUENT MATERIALS TO SURFACES, IN GENERAL
- B05B—SPRAYING APPARATUS; ATOMISING APPARATUS; NOZZLES
- B05B17/00—Apparatus for spraying or atomising liquids or other fluent materials, not covered by the preceding groups
- B05B17/04—Apparatus for spraying or atomising liquids or other fluent materials, not covered by the preceding groups operating with special methods
- B05B17/06—Apparatus for spraying or atomising liquids or other fluent materials, not covered by the preceding groups operating with special methods using ultrasonic or other kinds of vibrations
- B05B17/0607—Apparatus for spraying or atomising liquids or other fluent materials, not covered by the preceding groups operating with special methods using ultrasonic or other kinds of vibrations generated by electrical means, e.g. piezoelectric transducers
- B05B17/0615—Apparatus for spraying or atomising liquids or other fluent materials, not covered by the preceding groups operating with special methods using ultrasonic or other kinds of vibrations generated by electrical means, e.g. piezoelectric transducers spray being produced at the free surface of the liquid or other fluent material in a container and subjected to the vibrations
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M11/00—Sprayers or atomisers specially adapted for therapeutic purposes
- A61M11/005—Sprayers or atomisers specially adapted for therapeutic purposes using ultrasonics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M15/00—Inhalators
- A61M15/0001—Details of inhalators; Constructional features thereof
- A61M15/0013—Details of inhalators; Constructional features thereof with inhalation check valves
- A61M15/0015—Details of inhalators; Constructional features thereof with inhalation check valves located upstream of the dispenser, i.e. not traversed by the product
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M15/00—Inhalators
- A61M15/0085—Inhalators using ultrasonics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M11/00—Sprayers or atomisers specially adapted for therapeutic purposes
- A61M11/001—Particle size control
- A61M11/002—Particle size control by flow deviation causing inertial separation of transported particles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M11/00—Sprayers or atomisers specially adapted for therapeutic purposes
- A61M11/006—Sprayers or atomisers specially adapted for therapeutic purposes operated by applying mechanical pressure to the liquid to be sprayed or atomised
- A61M11/008—Sprayers or atomisers specially adapted for therapeutic purposes operated by applying mechanical pressure to the liquid to be sprayed or atomised by squeezing, e.g. using a flexible bottle or a bulb
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M15/00—Inhalators
- A61M15/0001—Details of inhalators; Constructional features thereof
- A61M15/0021—Mouthpieces therefor
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M2206/00—Characteristics of a physical parameter; associated device therefor
- A61M2206/10—Flow characteristics
- A61M2206/14—Static flow deviators in tubes disturbing laminar flow in tubes, e.g. archimedes screws
Definitions
- This invention relates to medical devices for the inhalation of medication and, more particularly, to a novel and improved nebulizer which is specifically adapted for use in the inhalation of medication but having useful application on other devices employing a piezoelectric crystal for ultrasonic stimulation and excitation such as emulsifiers, cleaners and the like.
- Pulmonary drug delivery systems commonly referred to medically as nebulizers, come in various forms. These, in turn can be broken down into various sub-groups.
- the atomizer type of device uses the venturi principle of air passing across a pipe or orifice to draw liquid medication from a storage receptical and atomize it into small particles.
- Such devices can be operated by squeezing a bulb or with a pressurized container.
- the ultrasonic energy When ultrasonic energy of the right frequency and power is applied to a liquid, a very fine particle mist is released from the surface.
- the ultrasonic energy can be produced by electrically exciting a piezoelectric-material, such as, lead zirconate titonate, and mechanically coupling that material to the liquid.
- a piezoelectric-material such as, lead zirconate titonate
- mechanically coupling that material to the liquid.
- some is converted to heat in the piezoelectric material, some may be converted to heat in the liquid, and the remainder is consumed at the liquid surface in the process of breaking away particles to form the mist.
- this process is called nebulization and is used to convert medication to a mist for inhalation in the treatment of respiratory disease.
- the medication should be nebulized into particles or droplets of a particular size range and, as a general rule, the smaller the particles the better the penetration of the particles into the lungs and the bronchial passageways.
- ultrasonic nebulizers were intended for use primarily in the home or medical facility environment.
- miniaturization and the availability of small, highly efficient, rechargeable battery packs make it highly desirable to provide portable ultrasonic nebulizers which can be hand-carried and used as required in the treatment of respiratory disease.
- ultrasonic nebulizers which have employed a piezoelectric material have encountered numerous problems, among which is the tendency of the material to rapidly degrade owing to the generation of heat, cavitation of the liquid caused by the high acoustic energy level, and chemical attack of the surface by medications and cleaning agents. Each time that acoustic energy crosses from one material to another, some is passed and some is reflected. Any material positioned between the transducer and the liquid for protecting the surface should possess high energy transmission efficiency and low energy reflection back to the transducer.
- this condition can be created by providing a thin coating or plating of approximately 1/100 W, such as, teflon, polyimide or gold, or providing a cover having a thickness of W/2 or a multiple thereof, such as, W, 3W/2, 2W attached to the transducer surface where ⁇ W ⁇ is the wavelength of the excitation signal.
- a cover having a thickness of W/2 or a multiple thereof, such as, W, 3W/2, 2W attached to the transducer surface where ⁇ W ⁇ is the wavelength of the excitation signal.
- Glass is a preferred material for such a cover because it presents an easily cleaned and durable surface to the liquid and can tolerate high temperatures. Nevertheless, a coupling agent is required to bridge the air gap between the two surfaces.
- U.S. Pat. No. 4,109,863 to Olson et al it was proposed to employ adhesives for this purpose.
- Olson et al proposed to solve the problem of high temperatures at the transducer surface by circulating a cooling water over the transducer and glass, but this method is not feasible for a portable handheld device and has the additional undesirable effect of acoustically damping the back side of the transducer and thus reducing the efficiency of the nebulizer system.
- oil of the correct viscosity and temperature capability as a coupling agent.
- the oil tends to migrate toward the high energy density center of the transducer/glass interface and occurs even after high temperatures have forced some of the oil to the periphery.
- the gap between the protective cover and the transducer surface must be so shaped as to provide an optimum oil film thickness thereacross which will avoid regularly generated reflections.
- it is important to contain the oil so that gravity and capillary forces do not carry it away from the gap during periods of inactivity. Accordingly it is important that the oil be confined or sealed in such a way as to assure that it will migrate towards the center of the gap when energy is applied.
- U.S. Pat. No. 3,433,461 to Scarpa employs a piezoelectric crystal bonded to a support layer. Both the crystal and the support layer were chosen to be one-half wavelength in thickness and bonded together with an adhesive to form a composite structure one wavelength in thickness. This structure is supported around its periphery and contains a thin web between the vibrating center and supported periphery to prevent support structure loading which is counter productive to efficient high energy vibration.
- Other patents of interest are U.S. Pat. No. 4,094,317 to Wasnich and U.S. Pat. No. 3,861,386 to Harris where an acoustic wave form is shaped to perform ultrasonic nebulization of the liquid and to isolate the liquid from the piezoelectric crystal and prevent dry operation of the device.
- Another object of the present invention is to provide in an ultrasonic nebulizer for a novel and approved piezoelectric transducer and wherein the means for acoustically coupling the ultrasonic energy from the piezoelectric element to a face plate is a liquid; and further wherein the gap formed between the face plate and piezoelectric element is so formed that the energy transfer is maximized and heating minimized so as to avoid the necessity for external means of cooling.
- a further object of the present invention is to provide in an ultrasonic nebulizer for a novel and improved method and means for mounting a piezoelectric crystal and protective cover and face plate which will maintain an optimum gap between the elements notwithstanding pressure increases created by thermal expansion of the coupling fluid; and further wherein the mounting means will act as a reservoir for the coupling fluid and retain any entrapped gases therein so as to prevent decay of the coupling efficiency otherwise resulting from gas build up.
- an assembly having a cavity therein for holding a liquid medication to be nebulized by a piezoelectric crystal disposed in communication with the cavity and separated from medication contained in the cavity by a thin cover of a material having characteristics for allowing it to match acoustical impedances without significant attenuation, such as, those possessed by glass, the crystal being disposed adjacent to the cover; a thin film of an energy-coupling fluid interposed between the cover and the surface of the crystal; and, sealing means for the cover and the surface of the crystal for preventing loss of fluid from between the cover and the surface of the crystal.
- the cavity has a hole in the bottom thereof communicating with the surface of the crystal; and, the cover comprises a sheet of glass, or the like, disposed over the surface of the crystal.
- the cavity has a hole in the bottom thereof communicating with the surface of the crystal; and, the cover comprises the bottom of a unitary bowl insert of a glass-like material inserted into the cavity.
- the bowl unit is of unitary construction and the cover comprises the bottom of the cavity which is formed therein.
- the improvement comprises a protective cover member of a predetermined wavelength superimposed on the transducer, the cover member and transducer having generally planar confronting surfaces and a common interface therebetween, annular sealing means in outer surrounding relation to the cover member to prevent the loss of fluid from the interface, and oil coupling means in the interface for coupling the ultrasonic energy from the transducer to the cover member.
- the transducer is a piezoelectric crystal having a top electrode extending down the sides and wrapping around the bottom edge and a bottom disc electrode of substantially smaller diameter than the diameter of the piezoelectric crystal whereby the electrical contact to the bottom of the piezoelectric crystal thereof is adjacent to the center thereof.
- FIG. 1 is a partially exploded, simplified, cutaway drawing of a prior art ultrasonic nebulizer
- FIG. 2 is a drawing of the prior art nebulizer of FIG. 1 shown assembled and showing its manner of operation;
- FIG. 3 is an enlarged, detailed, cutaway drawing of the bowl portion of a nebulizer according to the present invention in a first embodiment thereof;
- FIG. 4 is a simplified cutaway drawing through a piezoelectric crystal as employed in prior art ultrasonic nebulizers showing the manner of vibrational propagation therethrough;
- FIG. 5 is a simplified cutaway drawing through a piezoelectric crystal as employed in the ultrasonic nebulizer of the present invention with its protective covering and showing the manner of vibrational propagation therethrough;
- FIG. 6 is an enlarged, detailed, cutaway drawing of the bowl portion of a nebulizer according to the present invention in a second embodiment thereof;
- FIG. 7 is an enlarged, detailed, cutaway drawing of the bowl portion of a nebulizer according to the present invention in a third embodiment thereof;
- FIG. 8 is a simplified cutaway drawing through a prior art vibrational surface specially shaped to direct the energy waves toward the center thereof;
- FIG. 9 is a simplified cutaway drawing through a prior art composite structure for a piezoelectric crystal wherein the crystal is adhesively attached to a vibrating support structure and the virbating portion is decoupled from the actual support area;
- FIG. 10 is a simplified cutaway through a prior art structure wherein the liquid to be nebulized is contained in a separate container;
- FIG. 11 is a sectional view of a preferred form of portable nebulizer unit in accordance with the present invention.
- FIG. 12 is a detailed view in section of the piezoelectric transducer assembly.
- FIG. 13 is a bottom view of the preferred form of crystal employed in accordance with the present invention.
- prior art nebulizers such as, that generally indicated at 10 in FIG. 1 in exploded view, comprise a power pack 12 containing batteries, not shown, if it is a portable unit, or are adapted to be plugged into a wall outlet in the case of non-portable units.
- the power pack 12 is connected by power cable 14 to the nebulizing unit 16.
- the nebulizing unit 16 in turn, comprises a bowl portion 18 over which a cover 20 is adapted to be positioned.
- the cover 20 has a mouthpiece mounting tube 22 through the sidewalls thereof into which mouthpiece 24 can be press fit.
- the bowl portion 18, cover 20, tube 22 and mouthpiece 24 are usually cylindrical in cross section.
- the same components are also typically made of high impact plastic for light weight, ease of cleaning, and non-contamination.
- the bowl portion 18 contains a bowl-shaped cavity 26 in the top thereof into which the liquid medication 28 (see FIG. 2) is poured.
- a piezoelectric crystal 30 is positioned under the cavity 26 and the bottom of the cavity 26 has a circular hole 32 therein communicating with the top of the piezoelectric crystal 30.
- the button 34 on the top of the power pack 12 is depressed, causing the piezoelectric crystal 30 to have power applied thereto. That, in turn, causes the crystal 30 to vibrate at ultrasonic frequency and nebulize a portion of the liquid medication disposed within the hole 32 and on top of the surface of the piezoelectric crystal 30.
- the atomized droplets 36 produced are inhaled through the mouthpiece 24 in combination with air, indicated by the arrows 38, which is drawn in through the entry pipe 40 in the top of the cover 20 provided for that purpose.
- the piezoelectric crystal 88 is bonded to a support layer 90 which actually contacts the liquid. Both the crystal 88 and the support layer 90 were chosen to be one-half wavelength in thickness and then bonded together with an adhesive 92 to form a composite structure 86 one wavelength in thickness.
- the composite structure 86 is supported about its periphery and contains a thin web 94 between the vibrating center portion and the supported periphery 96 to prevent support structure loading thereof which is counterproductive to efficient high energy vibration.
- a vibrating surface is shown on which the liquid to be nebulized is in contact in order to focus the energy waves towards the center of the liquid in a concentrated energy area.
- the vibrating surface 98 in FIG. 8 is in the form of a Fresnel lens, which aims or directs the vibrational energy, indicated by the dotted lines 100, towards a plane passing through the center.
- a second technique is shown in simplified form in FIG. 10 and comprises placing the liquid to be nebulized 102 in a small container 104 having a thin, vibratable bottom surface 106 and placing the small container 104 in a large container 108 filled with liquid 110 (such as water) and having the piezoelectric crystal 30 at the bottom thereof.
- liquid 110 such as water
- the crystal 30 is always liquid-covered.
- the energy waves travel through the liquid 110 in the large container 108 and strike the bottom surface 106 of the small container 104, causing it to vibrate an amount sufficient to nebulize the liquid 102 and cause the droplets 112.
- FIG. 3 The improved bowl portion of an ultrasonic nebulizer similar to the prior art nebulizer of FIGS. 1 and 2 and modified according to the present invention is shown in detail in FIG. 3 and labelled therein as 18'. It is designed to be used in conjunction with a power pack 12 and cover 20, as previously described with respect to FIGS. 1 and 2, and in the interest of simplicity and the avoiding of redundancy in the description and drawings, those portions will not be shown or described hereinafter.
- the improvement to a piezoelectric crystal constructed assembly of the present invention as used in a nebulizer includes a protective covering for the piezoelectric crystal and a revised construction of the crystal itself.
- the piezoelectric crystal 30' of the present invention in the first embodiment thereof has a protective pyrex glass covering 42 disposed over the surface thereof and under the hole 32 in the bottom of the cavity 26.
- the piezoelectric crystal 30' is 0.77 inches in diameter and the glass covering 42 is 0.61 inches in diameter.
- the glass covering 42 is one-half wavelength of the crystal's frequency in thickness, which was found to give preferred coupling to the medication 28 shown in FIG. 2. Since the frequency being employed is about 1.65 MHz, the thickness of the glass covering 42 is approximately 0.064 inches. It should be noted at this point that while the tested example being described here employs a protective pyrex glass covering, other materials known to those skilled in the art could, of course, be employed. For example, certain plastics and ceramic materials would undoubtedly make good substitutes. Likewise, while a circular disc is shown and preferred for ease of manufacture, other shapes could, of course, be used and the term "disc” is not to be construed as a limitation, but rather, a term of convenience only.
- fluids of a particular type and exhibiting particular coupling characteristics are described hereinafter by way of example, those skilled in the art will recognize and appreciate that there are other materials, which could be easily overlooked in the broad classification of "fluids", which could be substituted as the coupling fluid.
- fluid is used in the descriptions herein and in the claims appended hereto, it is the applicants' intent that it be considered in its broadest sense as including other coupling fluids possessing the necessary qualities and characteristics as set forth in detail hereinafter. As to some of the fluids which were tested and found to be unsuitable, some were quickly destroyed while others were not.
- oil fluids ultimately employed by the applicants as a film between the crystal and its closely adjacent, spaced, protective cover have the property of being “self protecting and self healing”; that is, when destructive conditions appear, the oil film will move out of the most active (and destructive) areas. After the detrimental conditions have left; i.e., there is medicine in the bowl and a good impedance match, the oil "pumps” itself back into the necessary areas to allow good acoustic coupling.
- acoustic coupling fluids which are appropriate include--viscosity, viscosity breakdown, temperature stability, acoustic impedance, chemical stability, and molecular composition. These properties will now be addressed individually.
- Viscosity Through empirical analysis, the applicants herein were able to determine the workable limits of viscosity. Bounding the low end is the ability to manufacture the assembly. If the fluid is too thin (under 1 centistoke at 100° C. for oil), it is very difficult to intimately join the crystal and the glass without excessive air entrapping itself (enough to significantly decrease life or couple effectively). On the high end (above 100 centistoke at 100° C. for oil), the fluid still passes the acoustical energy; but, attenuation becomes significant. The higher viscosity fluids tested produced lower output as compared to the fluid viscosities. It is desirable for the fluid to have a viscosity curve which is as flat as possible. This provides uniformity as the temperature of the system changes. The preferred viscosity range is between 4 and 10 centistoke at 100° C. for an oil coupling. In this range, there were no detectable differences in either coupling or life.
- Viscosity Breakdown Because of the high energy densities of the reflected acoustic wave when impedances are mismatched (i.e., air only, no medicine) corresponding high temperatures are found in the interface between the crystal and the glass containing the fluid. To maintain the desired viscosity range and reasonable life, the fluid should not undergo permanent changes in viscosity when exposed to the high temperature and energy densities involved.
- Temperature Stability As previously mentioned, the fluid is subject to very high temperature gradients. Therefore, the fluid needs to have high operating temperature limits as well as a reasonably flat viscosity curve. Temperature requirements are met if the flash point is above 200° C. and there is no viscosity breakdown after repeated thermal cycling.
- the fluid must also have an acoustic impedance which is acceptable to the assembly system at the desired frequency without significant attenuation. Ideal impedance matching between the crystal and cover is difficult to attain; however, through empirical testing, the applicants were able to determine that the window of acceptability was fairly large in a given family of fluids.
- Chemical Stability Some of the fluids tested failed to pass the acoustic energy after a limited number of uses. It is hypothesized that the high energy densities and thermal gradients caused the fluids to change chemical composition. Therefore, the fluid needs to maintain chemical composition when exposed to high temperature and energy densities. Synthetic oils appear to have the ability to take the harsh conditions and maintain their initial properties.
- the fluid preferred by applicants, as a group, is synthetic oil based.
- the preferred embodiment as presently employed by the applicants in the commercial embodiments of the present invention is an 8 centistoke (at 100° C.) Polyalphaolefin base oil.
- the assembly When initially excited, the assembly attempts to pump fluid into the center of activity to correctly match acoustical impedances.
- the mechanism of this movement is not fully understood but the applicants hypothesize that a slow moving, travelling wave is created between the crystal surface and the protective glass cover similar to peristaltic pumping. This wave slowly brings in the necessary amount of fluid to complete coupling and better match the acoustic impedance of the crystal to the glass and the medication, i.e., the preferred fluids actually make the assembly self-adjusting for optimum performance.
- the glass cover attains similar vibrational characteristics to the crystal, resulting in a stable standing wave with the fluid at the center of the assembly.
- the diameter of the glass cover 42 and crystal 30' were made the same and the two were merely pressed into the groove under the hole 32 originally provided for the crystal alone.
- the sealing configuration of FIG. 3 was finally developed.
- the diameter of the protective glass cover 42 was made smaller than the diameter of the crystal 30'.
- the coupling fluid 44 between the glass cover 42 and the surface of the crystal 30' the circumferencial edge was sealed with an adhesive 46.
- the preferred adhesive 46 sealing material is a two part epoxy which, when fully cured, provides a hard, rigid, attachment as well as sealing in the coupling fluid. Like the surface of the crystal 30', however, if exposed to the medication 28 at ultrasonic vibrational frequencies, the epoxy adhesive 46 would be quickly destroyed.
- a second seal was provided to isolate the edge seal of the epoxy adhesive 46 from the medication 28. That second seal is provided by positioning the edge of the outer periphery of the protective glass 42 and the adhesive 46 outside of the O-ring 48 and which is disposed in a circular groove 50 provided therefor below and surrounding the hole 32.
- O-ring 48 is of a diameter less than the diameter of the glass cover 42 and greater than the diameter of the hole 32.
- the crystal 30', protective glass cover 42 and O-ring 48 are held in position for operation under the bowl-shaped cavity 26 by the same mounting apparatus as in the prior art ultrasonic nebulizers previously discussed broadly under Background of the Invention.
- a metal cylindrical contact 52 connected to one wire 54 within power cable 14 is supported against the bottom of the crystal 30' by cylindrical plate 56 as a result of the screws 58 threaded into the bottom 60 of the bowl portion 18'.
- a thermal switch 62 connected to the other wire 64 within power cable 14, is pushed up against the bottom of the crystal 30' by insulating O-ring 66 and plate 56 in a manner common in the prior art.
- a piezoelectric crystal 30 as employed in prior art ultrasonic nebulizers, emulsifiers, cleaners, and the like, comprises a circular disc 68 of piezoelectric crystal material. Over the disc 68 two metal electrical contacts 70, 72 are bonded or plated. The upper contact 70 covers the top and sides and extends just around the bottom edge of the disc 68. The bottom contact 72 is a disc that covers the bottom of the disc 68 except for a small circumferencial spacing from the edge of the contact 70 to provide electrical isolation therefrom.
- a nebulizer bowl portion according to a second embodiment of the present invention is indicated therein as 18".
- the bowl portion 18 the bowl 26' itself has no hole in the bottom as in the previously described embodiment. Rather, the bottom of the bowl 26' comprises a thin planar cover 76 of the same material as the rest of the bowl portion 18". This makes the inside surface of the bowl 26' smooth and without cracks or joints. Such a design is sanitary and easy to clean.
- This embodiment would lend itself particularly well to being formed of one of the modern ceramic materials or high temperature plastics developed from space technology.
- the piezoelectric crystal 68 is closely spaced and coupled directly to the planar cover 76 by the coupling fluid 44.
- a peripheral seal 78 such as, an O-ring, adhesive, or the like is disposed between the crystal 68 and the bottom 80 of the planar cover 76 to prevent the loss of the fluid 44, as previously described.
- a nebulizer bowl portion according to a third embodiment of the present invention is indicated therein as 18'".
- the bowl 26' itself has hole 32' in the bottom as in the previously described embodiment of FIG. 3.
- a unitary bowl insert 82 is disposed within the bowl 26" and over the hole 32'.
- the bowl insert can be of pyrex glass, plastic, ceramic, or the like, as desired. This design too is sanitary and easy to clean.
- the piezoelectric crystal 68 is closely spaced and coupled directly to the bottom 84 of the bowl insert 82 by the coupling fluid 44.
- a peripheral seal 78' such as, an O-ring, adhesive or the like is disposed between the crystal 68 and the bottom 84 of the bowl insert 82 to prevent the loss of the fluid 44, as previously described.
- FIGS. 11 to 14 A novel and improved form of portable nebulizer unit is illustrated in FIGS. 11 to 14 and comprises a generally cylindrical housing 120 which is divided into an upper chamber area 121 and a lower bowl section 122.
- the lower bowl section 122 defines a cavity 123 with a hole 124 in the bottom of the cavity directly above a piezoelectric crystal 126.
- the crystal 126 is covered by a one-half wave glass cover plate 127, the plate 127 being resiliently urged against an upper surface of the crystal by an elastomeric boot 128.
- boot 128 has an outer wall 130 which encircles the perimeter of the crystal 126 and plate 127 with a reservoir 129 in communication with the external edge of interface 125 between the crystal 126 and cover plate 127.
- the boot 128 has upper and lower annular return flanges 131 and 132, respectively, and is dimensioned such that it must be stretched over the crystal 126 and cover plate 127 so that the crystal 126 and cover plate 127 are pressed together in close-fitting sealed relation to the boot 128 without the necessity of an adhesive.
- An energy coupling oil film 133 is placed in the interface or gap 125.
- thermoswitch 134 is supported beneath the crystal 126 by an annular plastic support member 136, and a cable retainer has a power pack connection 139 for a power pack unit, not shown.
- a leaf spring contact 142 is interposed between the center or positive electrode 143 on the undersurface of the crystal 126 and is connected to a positive electrical strap 144 extending downwardly into the power pack connection 139.
- a negative electrical strap or lead 145 establishes contact with the outer, negative electrode 146 of the crystal and extends into the power pack connection 138.
- the upper chamber area 121 is made up of inner and outer concentric tubes 150 and 151, respectively, which are arranged coaxially and in direct communication with respect to the bowl unit 122.
- the inner concentric tube 150 terminates at its upper end in an enlarged annular seat portion 152 which receives an on-off valve assembly 154, the valve assembly provided with flap valve members 156.
- the valve member 156 is a thin resilient membrane of generally circular configuration which is secured to a fixed hub 158 and radiates outwardly across openings 160. The valve membrane is normally biased in a direction closing the valve but when a negative pressure is created in the interior of the tube 150 it will cause the circular membrane to open and admit outside air in the direction of the arrows through the inner tube 150.
- the necessary negative pressure or suction is created by means of a mouthpiece 162 in communication with the concentric space 163 between the tubes 150 and 151 so as to cause air to be drawn downwardly through the tube and into the cavity of the bowl unit 122 so as to pick up particles of liquid medication generated by the piezoelectric crystal and which particles tend to erupt into a somewhat conical-shaped turbulent fountain within the cavity area formed by the bowl unit.
- the particles are entrained in the airstream and flow upwardly along a spiral flow path created by a spirally extending baffle 164 on the external surface of the inner tube 150 beneath the mouthpiece 162.
- Ultrasonic nebulizers typically produce a range of particle sizes, a significant number of which are larger than those clinically useful. These larger particles do not reach the respiratory tissues targeted for treatment and therefore represented wasted medication.
- the upper section of the nebulizer is provided with a particle impaction baffle 164 as described. The baffle will accelerate the particles through a circular path on their way to the mouthpiece and only the larger particles will tend to accumulate on the sidewalls and flow back downwardly into the bowl unit to be renebulized. As a result, essentially all liquid medication is converted to a mist of clinically useful particles to insure accurate and economical treatment.
- the crystal 126 has a center electrode 143 and outer spaced concentric negative electrode 146 surrounding the top surface and outer perimeter of the crystal.
- the electrodes are composed of a thin coating or plating, such as, nickel, silver or gold. It is important that the coating selected be such that it will not tend to separate from the surface of the crystal and cause acoustic energy coupling losses and resultant reduction in nebulization.
- the cover plate 127 is preferably a glass material having a thickness of one-half wave length or a multiple thereof, such as, W, 3W/2, 2W and which is assembled to the transducer or crystal surface. Again, glass is a convenient material for such a cover since it presents an easily cleaned and durable surface to the liquid and can tolerate high temperatures.
- the liquid coupling film 133 serves to bridge the gap formed between the two confronting surfaces of the crystal 126 and cover plate 127.
- the gap formed is a generally circular recess defined by a planar surface 126' and concave surface 127' on the crystal 126 and cover plate 127, respectively.
- the gap or recess avoids problems associated with a uniform recess depth which were found to lead to destruction of the transducer surface caused by concentric standing wave activity in the oil layer.
- the success of the oil coupling system suggests that the oil be contained so that gravity and capillary forces do not carry the coupling oil out of the gap during periods of inactivity.
- the reservoir 129 formed in the boot permits storage of excess oil at the periphery of the gap and allows migration of the oil 133 toward the center when energy is applied to the transducer.
- the oil reservoir 129 permits the oil to expand with increased temperature rather than to separate the transducer from the glass.
- the boot 128 reduces damping by acoustically isolating the vibrating transducer and glass assembly from the outer housing.
Abstract
Description
Claims (10)
Priority Applications (8)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US07/266,823 US4976259A (en) | 1986-12-22 | 1988-11-02 | Ultrasonic nebulizer |
CA000610511A CA1329083C (en) | 1988-11-02 | 1989-09-07 | Ultrasonic nebulizer |
GB8922417A GB2224446B (en) | 1988-11-02 | 1989-10-05 | Ultrasonic nebulizer |
IT00955289A IT1236320B (en) | 1988-11-02 | 1989-10-30 | DEVICE FOR ULTRASONIC NEBULIZATION OF FLUIDS, FOR RESPIRATORY INHALATION AND OTHER |
DE3936248A DE3936248A1 (en) | 1988-11-02 | 1989-10-31 | ULTRASONIC SPRAYER |
JP1287255A JPH02243165A (en) | 1988-11-02 | 1989-11-02 | Ultrasonic atomizer for liquid |
AU43986/89A AU4398689A (en) | 1988-11-02 | 1989-11-02 | Ultrasonic nebulizer |
FR8914372A FR2638362A1 (en) | 1988-11-02 | 1989-11-02 | ULTRASONIC NEBULIZER COMPRISING A PIEZOELECTRIC TRANSDUCER |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US94420386A | 1986-12-22 | 1986-12-22 | |
US07/266,823 US4976259A (en) | 1986-12-22 | 1988-11-02 | Ultrasonic nebulizer |
Related Parent Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
US94420386A Continuation-In-Part | 1986-12-22 | 1986-12-22 |
Publications (1)
Publication Number | Publication Date |
---|---|
US4976259A true US4976259A (en) | 1990-12-11 |
Family
ID=23016138
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
US07/266,823 Expired - Fee Related US4976259A (en) | 1986-12-22 | 1988-11-02 | Ultrasonic nebulizer |
Country Status (8)
Country | Link |
---|---|
US (1) | US4976259A (en) |
JP (1) | JPH02243165A (en) |
AU (1) | AU4398689A (en) |
CA (1) | CA1329083C (en) |
DE (1) | DE3936248A1 (en) |
FR (1) | FR2638362A1 (en) |
GB (1) | GB2224446B (en) |
IT (1) | IT1236320B (en) |
Cited By (99)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5134993A (en) * | 1988-12-13 | 1992-08-04 | Siemens Aktiengesellschaft | Inhalator device, in particular a pocket inhalator |
US5170782A (en) * | 1991-09-12 | 1992-12-15 | Devilbiss Health Care, Inc. | Medicament nebulizer with improved aerosol chamber |
US5429302A (en) * | 1993-05-19 | 1995-07-04 | Fisons Corporation | Nebulizing element and device |
US5435282A (en) * | 1994-05-19 | 1995-07-25 | Habley Medical Technology Corporation | Nebulizer |
US5452711A (en) * | 1992-12-24 | 1995-09-26 | Exar Corporation | Small form factor atomizer |
US5485828A (en) * | 1992-04-29 | 1996-01-23 | Hauser; Jean-Luc | Portable device for micropulverization generated by ultrasound waves |
US5551416A (en) * | 1991-11-12 | 1996-09-03 | Medix Limited | Nebuliser and nebuliser control system |
US5586550A (en) * | 1995-08-31 | 1996-12-24 | Fluid Propulsion Technologies, Inc. | Apparatus and methods for the delivery of therapeutic liquids to the respiratory system |
US5644186A (en) * | 1995-06-07 | 1997-07-01 | Halliburton Company | Acoustic Transducer for LWD tool |
US5758637A (en) * | 1995-08-31 | 1998-06-02 | Aerogen, Inc. | Liquid dispensing apparatus and methods |
US5788665A (en) * | 1989-08-28 | 1998-08-04 | Alliance Pharmaceutical Corp. | Apparatus for pulmonary therapy |
US5918593A (en) * | 1997-06-20 | 1999-07-06 | Dragerwerk Ag | Ultrasonic atomizer for respiration systems |
US5927547A (en) * | 1996-05-31 | 1999-07-27 | Packard Instrument Company | System for dispensing microvolume quantities of liquids |
US5950619A (en) * | 1995-03-14 | 1999-09-14 | Siemens Aktiengesellschaft | Ultrasonic atomizer device with removable precision dosating unit |
US5970974A (en) * | 1995-03-14 | 1999-10-26 | Siemens Aktiengesellschaft | Dosating unit for an ultrasonic atomizer device |
US6014970A (en) * | 1998-06-11 | 2000-01-18 | Aerogen, Inc. | Methods and apparatus for storing chemical compounds in a portable inhaler |
US6085740A (en) * | 1996-02-21 | 2000-07-11 | Aerogen, Inc. | Liquid dispensing apparatus and methods |
US6152383A (en) * | 1999-11-22 | 2000-11-28 | King Ultrasonic Co., Ltd. | Ultrasonic nebulizer |
US6203759B1 (en) | 1996-05-31 | 2001-03-20 | Packard Instrument Company | Microvolume liquid handling system |
US6205999B1 (en) | 1995-04-05 | 2001-03-27 | Aerogen, Inc. | Methods and apparatus for storing chemical compounds in a portable inhaler |
US6235177B1 (en) | 1999-09-09 | 2001-05-22 | Aerogen, Inc. | Method for the construction of an aperture plate for dispensing liquid droplets |
US6283118B1 (en) * | 1999-10-13 | 2001-09-04 | Hsueh-Yu Lu | Ultrasonic nebulizer |
US20020073990A1 (en) * | 2000-12-18 | 2002-06-20 | Xerox Corporation | Inhaler that uses focused acoustic waves to deliver a pharmaceutical product |
US20020077369A1 (en) * | 2000-12-18 | 2002-06-20 | Xerox Corporation | Method of using focused acoustic waves to deliver a pharmaceutical product |
US6521187B1 (en) | 1996-05-31 | 2003-02-18 | Packard Instrument Company | Dispensing liquid drops onto porous brittle substrates |
US6537817B1 (en) | 1993-05-31 | 2003-03-25 | Packard Instrument Company | Piezoelectric-drop-on-demand technology |
US20030062038A1 (en) * | 2001-09-28 | 2003-04-03 | Omron Corporation | Inhalator attachment and nebulizer equipped with same |
US6543443B1 (en) | 2000-07-12 | 2003-04-08 | Aerogen, Inc. | Methods and devices for nebulizing fluids |
US6546927B2 (en) | 2001-03-13 | 2003-04-15 | Aerogen, Inc. | Methods and apparatus for controlling piezoelectric vibration |
US6550472B2 (en) | 2001-03-16 | 2003-04-22 | Aerogen, Inc. | Devices and methods for nebulizing fluids using flow directors |
US6554201B2 (en) | 2001-05-02 | 2003-04-29 | Aerogen, Inc. | Insert molded aerosol generator and methods |
US6601777B2 (en) * | 2001-01-30 | 2003-08-05 | Msp Corporation | Suspended particle container for an atomizer |
US6622720B2 (en) * | 2000-12-18 | 2003-09-23 | Xerox Corporation | Using capillary wave driven droplets to deliver a pharmaceutical product |
US6629524B1 (en) | 2000-07-12 | 2003-10-07 | Ponwell Enterprises Limited | Inhaler |
WO2004017848A1 (en) * | 2002-08-23 | 2004-03-04 | Sheiman Ultrasonic Research Foundation Pty Ltd | Nebulizing and drug delivery device |
US20040050952A1 (en) * | 2002-09-18 | 2004-03-18 | Wen-Pin Chen | Aerosol impingement baffle |
US6726186B2 (en) * | 2000-08-16 | 2004-04-27 | Sonia Gaaloul | Apparatus for cleaning and refreshing fabrics with an improved ultrasonic nebulizer |
US6732944B2 (en) | 2001-05-02 | 2004-05-11 | Aerogen, Inc. | Base isolated nebulizing device and methods |
US20040124258A1 (en) * | 2002-12-18 | 2004-07-01 | Monitto Perry H. | Misting fogger |
US6782886B2 (en) | 1995-04-05 | 2004-08-31 | Aerogen, Inc. | Metering pumps for an aerosolizer |
US6845771B1 (en) * | 2002-05-07 | 2005-01-25 | Ronald Charles Love | Essential oil vaporizer |
US6948491B2 (en) | 2001-03-20 | 2005-09-27 | Aerogen, Inc. | Convertible fluid feed system with comformable reservoir and methods |
US6962151B1 (en) * | 1999-11-05 | 2005-11-08 | Pari GmbH Spezialisten für effektive Inhalation | Inhalation nebulizer |
US7100600B2 (en) | 2001-03-20 | 2006-09-05 | Aerogen, Inc. | Fluid filled ampoules and methods for their use in aerosolizers |
US20060201502A1 (en) * | 2005-03-09 | 2006-09-14 | Ric Investments, Llc. | Nebulizing drug delivery device with increased flow rate |
US20060201500A1 (en) * | 2005-03-09 | 2006-09-14 | Ric Investments, Llc. | Nebulizing drug delivery device for ventilator |
US20060201501A1 (en) * | 2005-03-09 | 2006-09-14 | Ric Investments, Llc | Nebulizing drug delivery device with interlock detection and temperature protection |
US20060243274A1 (en) * | 2005-03-09 | 2006-11-02 | Ric Investments, Llc | Nebulizing drug delivery device with barrier |
WO2007025068A2 (en) * | 2005-08-26 | 2007-03-01 | Ricciardi Jonathan J | Method and apparatus for optimizing aerosol generation with ultrasonic transducers |
US20080233001A1 (en) * | 2005-08-26 | 2008-09-25 | Ricciardi Jonathan J | Method And Apparatus For An Improved Aerosol Generator And Associated Uses And Equipment |
US20090044787A1 (en) * | 2007-08-15 | 2009-02-19 | Adams Georg B L | Efficient Reduced-Emissions Carburetor |
US20090044786A1 (en) * | 2007-08-15 | 2009-02-19 | Adams Georg B L | Efficient Reduced-Emissions Carburetor |
US20090200392A1 (en) * | 2008-02-13 | 2009-08-13 | L'oreal | Device for spraying a cosmetic composition while blowing hot or cold air |
US20090200395A1 (en) * | 2008-02-13 | 2009-08-13 | L'oreal | Spray head including a sonotrode |
US20090200398A1 (en) * | 2008-02-13 | 2009-08-13 | L'oreal | Spray head including a sonotrode with a composition feed channel passing therethrough |
US20100051717A1 (en) * | 2008-08-27 | 2010-03-04 | Hon Hai Precision Industry Co., Ltd. | Ultrasonic atomizer |
US7677467B2 (en) | 2002-01-07 | 2010-03-16 | Novartis Pharma Ag | Methods and devices for aerosolizing medicament |
US7748377B2 (en) | 2000-05-05 | 2010-07-06 | Novartis Ag | Methods and systems for operating an aerosol generator |
US7771642B2 (en) | 2002-05-20 | 2010-08-10 | Novartis Ag | Methods of making an apparatus for providing aerosol for medical treatment |
US7779831B1 (en) * | 2006-04-20 | 2010-08-24 | Ric Investments, Llc | Ultrasonic nebulizer with metal coated ultrasonic generator |
US20100236545A1 (en) * | 2006-06-07 | 2010-09-23 | Joachim Kern | Dosage inhaler |
US20100313883A1 (en) * | 2006-04-20 | 2010-12-16 | Koninklijke Philips Electronics N.V. | Ultrasonic bebulilzer with metal coated ultrasonic genrator |
US20110114744A1 (en) * | 2005-08-26 | 2011-05-19 | Ricciardi Jonathan J | Method and Apparatus for an Improved Aerosol Generator and Associated Uses and Equipment |
US7946291B2 (en) | 2004-04-20 | 2011-05-24 | Novartis Ag | Ventilation systems and methods employing aerosol generators |
US7971588B2 (en) | 2000-05-05 | 2011-07-05 | Novartis Ag | Methods and systems for operating an aerosol generator |
US20120060833A1 (en) * | 2009-02-20 | 2012-03-15 | Pari Pharma Gmbh | Inhalation therapy device |
US20120111970A1 (en) * | 2010-10-04 | 2012-05-10 | Stamford Devices Limited | Aerosol Generator |
US8196604B1 (en) | 2010-01-18 | 2012-06-12 | Ricciardi Jonathan J | Deployable automated vent cover device |
US8336545B2 (en) | 2000-05-05 | 2012-12-25 | Novartis Pharma Ag | Methods and systems for operating an aerosol generator |
US8359984B1 (en) | 2010-01-18 | 2013-01-29 | Wolf Ii John D | Portable automated vent cover |
US8382008B1 (en) | 2005-08-26 | 2013-02-26 | Jonathan J. Ricciardi | Optimized and miniaturized aerosol generator |
US8410669B2 (en) | 2010-09-24 | 2013-04-02 | China Steel Corporation | Piezoceramic transducer and method for manufacturing the same |
US8539944B2 (en) | 2002-01-07 | 2013-09-24 | Novartis Ag | Devices and methods for nebulizing fluids for inhalation |
US8616195B2 (en) * | 2003-07-18 | 2013-12-31 | Novartis Ag | Nebuliser for the production of aerosolized medication |
WO2015119588A1 (en) * | 2014-02-10 | 2015-08-13 | Gama Araştirma Patent Tasarim Ve Endüstri̇yel Ürünler San. Ti̇c. Ltd.Şti̇. | Wearable nebulizer |
US9108211B2 (en) | 2005-05-25 | 2015-08-18 | Nektar Therapeutics | Vibration systems and methods |
WO2016007356A1 (en) * | 2014-07-07 | 2016-01-14 | Microdose Therapeutx, Inc. | Inhalation device |
WO2016044775A1 (en) * | 2014-09-19 | 2016-03-24 | Aerovu Technologies, Inc. | Spacer device with flow rate spirometer cross reference to related application (s) |
US9339507B2 (en) | 2006-05-15 | 2016-05-17 | United Therapeutics Corporation | Treprostinil administration by inhalation |
US9339836B2 (en) | 2005-05-23 | 2016-05-17 | Biosonic Australia Pty Ltd | Ultrasonic atomization apparatus |
US20160279352A1 (en) * | 2014-01-13 | 2016-09-29 | Changzhou Zhengyuan Medical Technology Co., Ltd. | Portable high frequency ultrasonic nebulizer for the whole respiratory tract drug delivery |
RU2618917C2 (en) * | 2012-03-09 | 2017-05-11 | Вектура Гмбх | Mixing duct for inhalation device, and inhalation device |
WO2018031693A1 (en) * | 2016-08-09 | 2018-02-15 | Cashman Kathryn | Ampoule for inhalant device |
US9895464B2 (en) | 2013-04-01 | 2018-02-20 | Earl Vaughn Sevy | Axial, triple-separation, diffusion apparatus and method |
US9943621B2 (en) | 2013-04-01 | 2018-04-17 | Earl Vaughn Sevy | Atomization separating and silencing apparatus and method |
US10507258B2 (en) | 2013-04-01 | 2019-12-17 | Earl Vaughn Sevy | Compact, mobile, modular, integrated diffuser apparatus and method |
WO2020181238A1 (en) * | 2019-03-06 | 2020-09-10 | Kedalion Therapeutics, Inc. | Multi-dose ocular fluid delivery system |
US10806817B2 (en) | 2015-12-10 | 2020-10-20 | Earl Vaughn Sevy | Annular separator apparatus and method |
US10823438B1 (en) * | 2019-09-05 | 2020-11-03 | Altapure, Llc | Vent bypass system |
US11065358B2 (en) | 2016-02-11 | 2021-07-20 | Earl Vaughn Sevy | Air-blade, silencer and separator apparatus and method |
US20210268209A1 (en) * | 2018-07-24 | 2021-09-02 | Monash University | Nebulizer |
US20210330621A1 (en) | 2020-04-17 | 2021-10-28 | United Therapeutics Corporation | Treatment for interstitial lung disease |
TWI747773B (en) * | 2021-03-25 | 2021-11-21 | 心誠鎂行動醫電股份有限公司 | Drug delivery container and atomizing device |
US11247001B2 (en) * | 2016-09-30 | 2022-02-15 | De Motu Cordis Pty Ltd | Delivery device with cantilever structure and associated method of use |
US11389602B2 (en) * | 2017-07-19 | 2022-07-19 | Flaem Nuova S.P.A. | Nebulization device for medical mixture |
US11679028B2 (en) | 2019-03-06 | 2023-06-20 | Novartis Ag | Multi-dose ocular fluid delivery system |
US11819453B2 (en) | 2015-01-12 | 2023-11-21 | Novartis Ag | Micro-droplet delivery device and methods |
US11925577B2 (en) | 2020-04-17 | 2024-03-12 | Bausch + Lomb Ireland Limted | Hydrodynamically actuated preservative free dispensing system |
US11938057B2 (en) | 2020-04-17 | 2024-03-26 | Bausch + Lomb Ireland Limited | Hydrodynamically actuated preservative free dispensing system |
Families Citing this family (15)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE59107894D1 (en) * | 1991-03-21 | 1996-07-11 | Ritzau Pari Werk Gmbh Paul | Nebulizers, in particular for use in devices for inhalation therapy |
FR2699411B1 (en) * | 1992-12-23 | 1995-02-24 | Dp Medical | Nebulizer. |
DE19507410C2 (en) * | 1995-03-03 | 1997-05-22 | Gsf Forschungszentrum Umwelt | Method and device for producing aerosols |
EP0730877A1 (en) * | 1995-03-06 | 1996-09-11 | Fisons Corporation | Nebulizing element and device |
GB9604065D0 (en) * | 1996-02-27 | 1996-05-01 | Medix Ltd | A nebuliser |
BE1010763A3 (en) * | 1996-11-22 | 1999-01-05 | Vereniging Voor De Bevordering | METHOD AND APPARATUS FOR GENERATING drops. |
DE19934582C2 (en) * | 1999-07-23 | 2003-09-18 | Otto Schill Gmbh & Co Kg | aerosol generator |
DE19953317C1 (en) * | 1999-11-05 | 2001-02-01 | Pari Gmbh | Aerosol generation unit for inhalation therapies, comprises a valve which allows patient's exhaled air to enter into the surroundings, but prevents direct entry of external air into the mixing chamber during the inhaling phase |
DE10229538A1 (en) * | 2002-07-01 | 2004-01-15 | Siemens Ag | ultrasonic nebulizer |
US8763605B2 (en) | 2005-07-20 | 2014-07-01 | Manta Devices, Llc | Inhalation device |
US8156933B2 (en) | 2006-06-21 | 2012-04-17 | Puthalath Koroth Raghuprasad | Cloud nebulizer |
US11224704B2 (en) | 2007-07-06 | 2022-01-18 | Manta Devices, Llc | Dose delivery device for inhalation |
US9179691B2 (en) | 2007-12-14 | 2015-11-10 | Aerodesigns, Inc. | Delivering aerosolizable food products |
DE102009030185A1 (en) | 2009-06-24 | 2010-12-30 | Joachim Kern | Turboinhalator |
US11147936B2 (en) | 2014-05-02 | 2021-10-19 | Manta Devices, Llc | Dose delivery device with cover connected to dose chamber seal |
Citations (11)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3433461A (en) * | 1967-05-22 | 1969-03-18 | Edison Instr Inc | High-frequency ultrasonic generators |
US3774602A (en) * | 1972-01-03 | 1973-11-27 | American Hospital Supply Corp | Ultrasonic nebulizer for inhalation therapy |
US3828773A (en) * | 1972-09-22 | 1974-08-13 | Theratron Corp | Nebulizing apparatus and system |
US3861386A (en) * | 1966-01-12 | 1975-01-21 | Misto & Gen Equipment Co | Ultrasonic nebulizer |
US3866831A (en) * | 1973-10-10 | 1975-02-18 | Research Corp | Pulsed ultrasonic nebulization system and method for flame spectroscopy |
US3989042A (en) * | 1974-06-06 | 1976-11-02 | Tdk Electronics Company, Limited | Oscillator-exciting system for ultrasonic liquid nebulizer |
US4001650A (en) * | 1975-09-02 | 1977-01-04 | Puritan-Bennett Corporation | Method and apparatus for ultrasonic transducer protection |
US4094317A (en) * | 1976-06-11 | 1978-06-13 | Wasnich Richard D | Nebulization system |
US4109863A (en) * | 1977-08-17 | 1978-08-29 | The United States Of America As Represented By The United States Department Of Energy | Apparatus for ultrasonic nebulization |
US4113809A (en) * | 1977-04-04 | 1978-09-12 | Champion Spark Plug Company | Hand held ultrasonic nebulizer |
US4646967A (en) * | 1984-04-23 | 1987-03-03 | The Boeing Company | Ultrasonic water jet having electromagnetic interference shielding |
Family Cites Families (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB1069048A (en) * | 1964-02-10 | 1967-05-17 | Devilbiss Co | Method and apparatus for producing aerosols |
US3469785A (en) * | 1967-07-28 | 1969-09-30 | Macrosonics Corp | High frequency ultrasonic fog generator and method |
US3490697A (en) * | 1968-01-24 | 1970-01-20 | J J Monaghan Co Inc | Ultrasonic nebulizer |
US3561444A (en) * | 1968-05-22 | 1971-02-09 | Bio Logics Inc | Ultrasonic drug nebulizer |
FR2180958A1 (en) * | 1972-04-18 | 1973-11-30 | Hirtz Hans |
-
1988
- 1988-11-02 US US07/266,823 patent/US4976259A/en not_active Expired - Fee Related
-
1989
- 1989-09-07 CA CA000610511A patent/CA1329083C/en not_active Expired - Fee Related
- 1989-10-05 GB GB8922417A patent/GB2224446B/en not_active Expired - Lifetime
- 1989-10-30 IT IT00955289A patent/IT1236320B/en active IP Right Grant
- 1989-10-31 DE DE3936248A patent/DE3936248A1/en not_active Withdrawn
- 1989-11-02 FR FR8914372A patent/FR2638362A1/en not_active Withdrawn
- 1989-11-02 AU AU43986/89A patent/AU4398689A/en not_active Abandoned
- 1989-11-02 JP JP1287255A patent/JPH02243165A/en active Pending
Patent Citations (11)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3861386A (en) * | 1966-01-12 | 1975-01-21 | Misto & Gen Equipment Co | Ultrasonic nebulizer |
US3433461A (en) * | 1967-05-22 | 1969-03-18 | Edison Instr Inc | High-frequency ultrasonic generators |
US3774602A (en) * | 1972-01-03 | 1973-11-27 | American Hospital Supply Corp | Ultrasonic nebulizer for inhalation therapy |
US3828773A (en) * | 1972-09-22 | 1974-08-13 | Theratron Corp | Nebulizing apparatus and system |
US3866831A (en) * | 1973-10-10 | 1975-02-18 | Research Corp | Pulsed ultrasonic nebulization system and method for flame spectroscopy |
US3989042A (en) * | 1974-06-06 | 1976-11-02 | Tdk Electronics Company, Limited | Oscillator-exciting system for ultrasonic liquid nebulizer |
US4001650A (en) * | 1975-09-02 | 1977-01-04 | Puritan-Bennett Corporation | Method and apparatus for ultrasonic transducer protection |
US4094317A (en) * | 1976-06-11 | 1978-06-13 | Wasnich Richard D | Nebulization system |
US4113809A (en) * | 1977-04-04 | 1978-09-12 | Champion Spark Plug Company | Hand held ultrasonic nebulizer |
US4109863A (en) * | 1977-08-17 | 1978-08-29 | The United States Of America As Represented By The United States Department Of Energy | Apparatus for ultrasonic nebulization |
US4646967A (en) * | 1984-04-23 | 1987-03-03 | The Boeing Company | Ultrasonic water jet having electromagnetic interference shielding |
Cited By (156)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5134993A (en) * | 1988-12-13 | 1992-08-04 | Siemens Aktiengesellschaft | Inhalator device, in particular a pocket inhalator |
US5788665A (en) * | 1989-08-28 | 1998-08-04 | Alliance Pharmaceutical Corp. | Apparatus for pulmonary therapy |
US5170782A (en) * | 1991-09-12 | 1992-12-15 | Devilbiss Health Care, Inc. | Medicament nebulizer with improved aerosol chamber |
US5551416A (en) * | 1991-11-12 | 1996-09-03 | Medix Limited | Nebuliser and nebuliser control system |
US5485828A (en) * | 1992-04-29 | 1996-01-23 | Hauser; Jean-Luc | Portable device for micropulverization generated by ultrasound waves |
US5452711A (en) * | 1992-12-24 | 1995-09-26 | Exar Corporation | Small form factor atomizer |
US5429302A (en) * | 1993-05-19 | 1995-07-04 | Fisons Corporation | Nebulizing element and device |
US6537817B1 (en) | 1993-05-31 | 2003-03-25 | Packard Instrument Company | Piezoelectric-drop-on-demand technology |
US5435282A (en) * | 1994-05-19 | 1995-07-25 | Habley Medical Technology Corporation | Nebulizer |
US5970974A (en) * | 1995-03-14 | 1999-10-26 | Siemens Aktiengesellschaft | Dosating unit for an ultrasonic atomizer device |
US5950619A (en) * | 1995-03-14 | 1999-09-14 | Siemens Aktiengesellschaft | Ultrasonic atomizer device with removable precision dosating unit |
US6755189B2 (en) | 1995-04-05 | 2004-06-29 | Aerogen, Inc. | Methods and apparatus for storing chemical compounds in a portable inhaler |
US6205999B1 (en) | 1995-04-05 | 2001-03-27 | Aerogen, Inc. | Methods and apparatus for storing chemical compounds in a portable inhaler |
US6782886B2 (en) | 1995-04-05 | 2004-08-31 | Aerogen, Inc. | Metering pumps for an aerosolizer |
US8561604B2 (en) | 1995-04-05 | 2013-10-22 | Novartis Ag | Liquid dispensing apparatus and methods |
US6640804B2 (en) | 1995-04-05 | 2003-11-04 | Aerogen, Inc. | Liquid dispensing apparatus and methods |
US6467476B1 (en) | 1995-04-05 | 2002-10-22 | Aerogen, Inc. | Liquid dispensing apparatus and methods |
US5644186A (en) * | 1995-06-07 | 1997-07-01 | Halliburton Company | Acoustic Transducer for LWD tool |
US5586550A (en) * | 1995-08-31 | 1996-12-24 | Fluid Propulsion Technologies, Inc. | Apparatus and methods for the delivery of therapeutic liquids to the respiratory system |
US5758637A (en) * | 1995-08-31 | 1998-06-02 | Aerogen, Inc. | Liquid dispensing apparatus and methods |
US6085740A (en) * | 1996-02-21 | 2000-07-11 | Aerogen, Inc. | Liquid dispensing apparatus and methods |
US6079283A (en) * | 1996-05-31 | 2000-06-27 | Packard Instruments Comapny | Method for aspirating sample liquid into a dispenser tip and thereafter ejecting droplets therethrough |
US5927547A (en) * | 1996-05-31 | 1999-07-27 | Packard Instrument Company | System for dispensing microvolume quantities of liquids |
US6592825B2 (en) | 1996-05-31 | 2003-07-15 | Packard Instrument Company, Inc. | Microvolume liquid handling system |
US6203759B1 (en) | 1996-05-31 | 2001-03-20 | Packard Instrument Company | Microvolume liquid handling system |
US6083762A (en) * | 1996-05-31 | 2000-07-04 | Packard Instruments Company | Microvolume liquid handling system |
US6112605A (en) * | 1996-05-31 | 2000-09-05 | Packard Instrument Company | Method for dispensing and determining a microvolume of sample liquid |
US6422431B2 (en) | 1996-05-31 | 2002-07-23 | Packard Instrument Company, Inc. | Microvolume liquid handling system |
US6521187B1 (en) | 1996-05-31 | 2003-02-18 | Packard Instrument Company | Dispensing liquid drops onto porous brittle substrates |
US5918593A (en) * | 1997-06-20 | 1999-07-06 | Dragerwerk Ag | Ultrasonic atomizer for respiration systems |
US8578931B2 (en) | 1998-06-11 | 2013-11-12 | Novartis Ag | Methods and apparatus for storing chemical compounds in a portable inhaler |
US6014970A (en) * | 1998-06-11 | 2000-01-18 | Aerogen, Inc. | Methods and apparatus for storing chemical compounds in a portable inhaler |
US6235177B1 (en) | 1999-09-09 | 2001-05-22 | Aerogen, Inc. | Method for the construction of an aperture plate for dispensing liquid droplets |
US8398001B2 (en) | 1999-09-09 | 2013-03-19 | Novartis Ag | Aperture plate and methods for its construction and use |
US6283118B1 (en) * | 1999-10-13 | 2001-09-04 | Hsueh-Yu Lu | Ultrasonic nebulizer |
US6962151B1 (en) * | 1999-11-05 | 2005-11-08 | Pari GmbH Spezialisten für effektive Inhalation | Inhalation nebulizer |
US6152383A (en) * | 1999-11-22 | 2000-11-28 | King Ultrasonic Co., Ltd. | Ultrasonic nebulizer |
US7748377B2 (en) | 2000-05-05 | 2010-07-06 | Novartis Ag | Methods and systems for operating an aerosol generator |
US8336545B2 (en) | 2000-05-05 | 2012-12-25 | Novartis Pharma Ag | Methods and systems for operating an aerosol generator |
US7971588B2 (en) | 2000-05-05 | 2011-07-05 | Novartis Ag | Methods and systems for operating an aerosol generator |
US6629524B1 (en) | 2000-07-12 | 2003-10-07 | Ponwell Enterprises Limited | Inhaler |
US6543443B1 (en) | 2000-07-12 | 2003-04-08 | Aerogen, Inc. | Methods and devices for nebulizing fluids |
US6726186B2 (en) * | 2000-08-16 | 2004-04-27 | Sonia Gaaloul | Apparatus for cleaning and refreshing fabrics with an improved ultrasonic nebulizer |
US20020077369A1 (en) * | 2000-12-18 | 2002-06-20 | Xerox Corporation | Method of using focused acoustic waves to deliver a pharmaceutical product |
US6622720B2 (en) * | 2000-12-18 | 2003-09-23 | Xerox Corporation | Using capillary wave driven droplets to deliver a pharmaceutical product |
US8122880B2 (en) | 2000-12-18 | 2012-02-28 | Palo Alto Research Center Incorporated | Inhaler that uses focused acoustic waves to deliver a pharmaceutical product |
US20020073990A1 (en) * | 2000-12-18 | 2002-06-20 | Xerox Corporation | Inhaler that uses focused acoustic waves to deliver a pharmaceutical product |
US7121275B2 (en) * | 2000-12-18 | 2006-10-17 | Xerox Corporation | Method of using focused acoustic waves to deliver a pharmaceutical product |
US6601777B2 (en) * | 2001-01-30 | 2003-08-05 | Msp Corporation | Suspended particle container for an atomizer |
US6546927B2 (en) | 2001-03-13 | 2003-04-15 | Aerogen, Inc. | Methods and apparatus for controlling piezoelectric vibration |
US6550472B2 (en) | 2001-03-16 | 2003-04-22 | Aerogen, Inc. | Devices and methods for nebulizing fluids using flow directors |
US7100600B2 (en) | 2001-03-20 | 2006-09-05 | Aerogen, Inc. | Fluid filled ampoules and methods for their use in aerosolizers |
US8196573B2 (en) | 2001-03-20 | 2012-06-12 | Novartis Ag | Methods and systems for operating an aerosol generator |
US6948491B2 (en) | 2001-03-20 | 2005-09-27 | Aerogen, Inc. | Convertible fluid feed system with comformable reservoir and methods |
US6732944B2 (en) | 2001-05-02 | 2004-05-11 | Aerogen, Inc. | Base isolated nebulizing device and methods |
US6554201B2 (en) | 2001-05-02 | 2003-04-29 | Aerogen, Inc. | Insert molded aerosol generator and methods |
US20030062038A1 (en) * | 2001-09-28 | 2003-04-03 | Omron Corporation | Inhalator attachment and nebulizer equipped with same |
US6705312B2 (en) * | 2001-09-28 | 2004-03-16 | Omron Corporation | Inhalator attachment and nebulizer equipped with same |
US7677467B2 (en) | 2002-01-07 | 2010-03-16 | Novartis Pharma Ag | Methods and devices for aerosolizing medicament |
US8539944B2 (en) | 2002-01-07 | 2013-09-24 | Novartis Ag | Devices and methods for nebulizing fluids for inhalation |
US6845771B1 (en) * | 2002-05-07 | 2005-01-25 | Ronald Charles Love | Essential oil vaporizer |
US7771642B2 (en) | 2002-05-20 | 2010-08-10 | Novartis Ag | Methods of making an apparatus for providing aerosol for medical treatment |
US20060137680A1 (en) * | 2002-08-23 | 2006-06-29 | Vladimir Sheiman | Nebulizing and drug delivery device |
WO2004017848A1 (en) * | 2002-08-23 | 2004-03-04 | Sheiman Ultrasonic Research Foundation Pty Ltd | Nebulizing and drug delivery device |
US8001962B2 (en) | 2002-08-23 | 2011-08-23 | Sheiman Ultrasonic Research Foundation Pty Ltd. | Nebulizing and drug delivery device |
US20040050952A1 (en) * | 2002-09-18 | 2004-03-18 | Wen-Pin Chen | Aerosol impingement baffle |
US7229028B2 (en) * | 2002-09-18 | 2007-06-12 | Kai Chih Industrial Co., Ltd. | Aerosol impingement baffle |
US6854661B2 (en) * | 2002-12-18 | 2005-02-15 | Multi Media Electronics, Inc. | Misting fogger |
US20040124258A1 (en) * | 2002-12-18 | 2004-07-01 | Monitto Perry H. | Misting fogger |
US8616195B2 (en) * | 2003-07-18 | 2013-12-31 | Novartis Ag | Nebuliser for the production of aerosolized medication |
US7946291B2 (en) | 2004-04-20 | 2011-05-24 | Novartis Ag | Ventilation systems and methods employing aerosol generators |
US20060201502A1 (en) * | 2005-03-09 | 2006-09-14 | Ric Investments, Llc. | Nebulizing drug delivery device with increased flow rate |
US20060201500A1 (en) * | 2005-03-09 | 2006-09-14 | Ric Investments, Llc. | Nebulizing drug delivery device for ventilator |
US20100294269A1 (en) * | 2005-03-09 | 2010-11-25 | Koninklijke Philips Electronics N.V. | Nebulizing drug delivery device with an increased flow rate |
US7721729B2 (en) | 2005-03-09 | 2010-05-25 | Ric Investments, Llc | Nebulizing drug delivery device for ventilator |
US7631643B2 (en) | 2005-03-09 | 2009-12-15 | Ric Investments, Llc | Nebulizing drug delivery device with interlock detection and temperature protection |
US8056557B2 (en) * | 2005-03-09 | 2011-11-15 | Ric Investments, Llc | Nebulizing drug delivery device with barrier |
US20060243274A1 (en) * | 2005-03-09 | 2006-11-02 | Ric Investments, Llc | Nebulizing drug delivery device with barrier |
US20060201501A1 (en) * | 2005-03-09 | 2006-09-14 | Ric Investments, Llc | Nebulizing drug delivery device with interlock detection and temperature protection |
US7814901B2 (en) | 2005-03-09 | 2010-10-19 | Ric Investments, Llc | Nebulizing drug delivery device with increased flow rate |
US9339836B2 (en) | 2005-05-23 | 2016-05-17 | Biosonic Australia Pty Ltd | Ultrasonic atomization apparatus |
US9108211B2 (en) | 2005-05-25 | 2015-08-18 | Nektar Therapeutics | Vibration systems and methods |
US8382008B1 (en) | 2005-08-26 | 2013-02-26 | Jonathan J. Ricciardi | Optimized and miniaturized aerosol generator |
US7871016B2 (en) | 2005-08-26 | 2011-01-18 | Altapure, Llc | Method and apparatus for an improved aerosol generator and associated uses and equipment |
US20110114744A1 (en) * | 2005-08-26 | 2011-05-19 | Ricciardi Jonathan J | Method and Apparatus for an Improved Aerosol Generator and Associated Uses and Equipment |
US8177142B2 (en) | 2005-08-26 | 2012-05-15 | Ricciardi Jonathan J | Method and apparatus for an improved aerosol generator and associated uses and equipment |
US7641130B2 (en) | 2005-08-26 | 2010-01-05 | Altapure Llc | Methods and apparatus for optimizing aerosol generation with ultrasonic transducers |
WO2007025068A3 (en) * | 2005-08-26 | 2009-04-16 | Jonathan J Ricciardi | Method and apparatus for optimizing aerosol generation with ultrasonic transducers |
US20080233001A1 (en) * | 2005-08-26 | 2008-09-25 | Ricciardi Jonathan J | Method And Apparatus For An Improved Aerosol Generator And Associated Uses And Equipment |
US20070053789A1 (en) * | 2005-08-26 | 2007-03-08 | Ricciardi Jonathan J | Method and apparatus for optimizing aerosol generation with ultrasonic transducers |
WO2007025068A2 (en) * | 2005-08-26 | 2007-03-01 | Ricciardi Jonathan J | Method and apparatus for optimizing aerosol generation with ultrasonic transducers |
US7779831B1 (en) * | 2006-04-20 | 2010-08-24 | Ric Investments, Llc | Ultrasonic nebulizer with metal coated ultrasonic generator |
US20100313883A1 (en) * | 2006-04-20 | 2010-12-16 | Koninklijke Philips Electronics N.V. | Ultrasonic bebulilzer with metal coated ultrasonic genrator |
US10376525B2 (en) | 2006-05-15 | 2019-08-13 | United Therapeutics Corporation | Treprostinil administration by inhalation |
US10716793B2 (en) | 2006-05-15 | 2020-07-21 | United Therapeutics Corporation | Treprostinil administration by inhalation |
US9358240B2 (en) | 2006-05-15 | 2016-06-07 | United Therapeutics Corporation | Treprostinil administration by inhalation |
US9339507B2 (en) | 2006-05-15 | 2016-05-17 | United Therapeutics Corporation | Treprostinil administration by inhalation |
US11357782B2 (en) | 2006-05-15 | 2022-06-14 | United Therapeutics Corporation | Treprostinil administration by inhalation |
US20100236545A1 (en) * | 2006-06-07 | 2010-09-23 | Joachim Kern | Dosage inhaler |
US9155846B2 (en) * | 2006-06-07 | 2015-10-13 | United Therapeutics Corporation | Dosage inhaler |
US20090044786A1 (en) * | 2007-08-15 | 2009-02-19 | Adams Georg B L | Efficient Reduced-Emissions Carburetor |
US20090044787A1 (en) * | 2007-08-15 | 2009-02-19 | Adams Georg B L | Efficient Reduced-Emissions Carburetor |
US8430338B2 (en) | 2008-02-13 | 2013-04-30 | L'oreal | Spray head including a sonotrode with a composition feed channel passing therethrough |
US20090200392A1 (en) * | 2008-02-13 | 2009-08-13 | L'oreal | Device for spraying a cosmetic composition while blowing hot or cold air |
US8746586B2 (en) | 2008-02-13 | 2014-06-10 | L'oreal | Device for spraying a cosmetic composition while blowing hot or cold air |
US20090200398A1 (en) * | 2008-02-13 | 2009-08-13 | L'oreal | Spray head including a sonotrode with a composition feed channel passing therethrough |
US8556191B2 (en) * | 2008-02-13 | 2013-10-15 | L'oreal | Spray head including a sonotrode |
US20090200395A1 (en) * | 2008-02-13 | 2009-08-13 | L'oreal | Spray head including a sonotrode |
US20100051717A1 (en) * | 2008-08-27 | 2010-03-04 | Hon Hai Precision Industry Co., Ltd. | Ultrasonic atomizer |
US20120060833A1 (en) * | 2009-02-20 | 2012-03-15 | Pari Pharma Gmbh | Inhalation therapy device |
US8196604B1 (en) | 2010-01-18 | 2012-06-12 | Ricciardi Jonathan J | Deployable automated vent cover device |
US8359984B1 (en) | 2010-01-18 | 2013-01-29 | Wolf Ii John D | Portable automated vent cover |
US8410669B2 (en) | 2010-09-24 | 2013-04-02 | China Steel Corporation | Piezoceramic transducer and method for manufacturing the same |
US9289792B2 (en) * | 2010-10-04 | 2016-03-22 | Stamford Devices Limited | Aerosol generator |
US11446695B2 (en) | 2010-10-04 | 2022-09-20 | Stamford Devices Limited | Aerosol generator with electrical power conducting pins |
US11904340B2 (en) | 2010-10-04 | 2024-02-20 | Stamford Devices Limited | Aerosol generator |
US10695787B2 (en) | 2010-10-04 | 2020-06-30 | Stamford Devices Limited | Aerosol generator |
US10399109B2 (en) | 2010-10-04 | 2019-09-03 | Stamford Devices Limited | Aerosol generator |
US20120111970A1 (en) * | 2010-10-04 | 2012-05-10 | Stamford Devices Limited | Aerosol Generator |
US10322432B2 (en) | 2010-10-04 | 2019-06-18 | Stamford Devices Limited | Aerosol generator |
US10092924B2 (en) | 2010-10-04 | 2018-10-09 | Stamford Devices, Ltd. | Aerosol generator |
US10857310B2 (en) | 2012-03-09 | 2020-12-08 | Vectura Gmbh | Mixing channel for an inhalation device and inhalation device |
RU2618917C2 (en) * | 2012-03-09 | 2017-05-11 | Вектура Гмбх | Mixing duct for inhalation device, and inhalation device |
US10258714B2 (en) | 2013-04-01 | 2019-04-16 | Earl Vaughn Sevy | Axial, triple-separation, diffusion apparatus and method |
US10507258B2 (en) | 2013-04-01 | 2019-12-17 | Earl Vaughn Sevy | Compact, mobile, modular, integrated diffuser apparatus and method |
US9943621B2 (en) | 2013-04-01 | 2018-04-17 | Earl Vaughn Sevy | Atomization separating and silencing apparatus and method |
US9895464B2 (en) | 2013-04-01 | 2018-02-20 | Earl Vaughn Sevy | Axial, triple-separation, diffusion apparatus and method |
US10245345B2 (en) | 2013-04-01 | 2019-04-02 | Earl Vaughn Sevy | Atomization separating and silencing apparatus and method |
US10195368B2 (en) * | 2014-01-13 | 2019-02-05 | Changzhou Zhengyuan Medical Technology Co., Ltd. | Handheld high frequency ultrasonic nebulizer for whole respiratory tract drug delivery |
US20160279352A1 (en) * | 2014-01-13 | 2016-09-29 | Changzhou Zhengyuan Medical Technology Co., Ltd. | Portable high frequency ultrasonic nebulizer for the whole respiratory tract drug delivery |
WO2015119588A1 (en) * | 2014-02-10 | 2015-08-13 | Gama Araştirma Patent Tasarim Ve Endüstri̇yel Ürünler San. Ti̇c. Ltd.Şti̇. | Wearable nebulizer |
EP3804794A1 (en) * | 2014-07-07 | 2021-04-14 | MicroDose Therapeutx, Inc. | Inhalation device |
EA032922B1 (en) * | 2014-07-07 | 2019-08-30 | Майкродоуз Терапьютэкс, Инк. | Inhalation device |
CN106573120A (en) * | 2014-07-07 | 2017-04-19 | 微剂量治疗公司 | Inhalation device |
US10744278B2 (en) * | 2014-07-07 | 2020-08-18 | Microdose Therapeutx, Inc. | Inhalation device |
WO2016007356A1 (en) * | 2014-07-07 | 2016-01-14 | Microdose Therapeutx, Inc. | Inhalation device |
CN106573120B (en) * | 2014-07-07 | 2020-02-07 | 微剂量治疗公司 | Inhalation device |
AU2015288166B2 (en) * | 2014-07-07 | 2019-09-12 | Microdose Therapeutx, Inc. | Inhalation device |
US20170274161A1 (en) * | 2014-09-19 | 2017-09-28 | Aerovu Technologies, Inc. | Spacer device with flow rate spirometer |
WO2016044775A1 (en) * | 2014-09-19 | 2016-03-24 | Aerovu Technologies, Inc. | Spacer device with flow rate spirometer cross reference to related application (s) |
US11819453B2 (en) | 2015-01-12 | 2023-11-21 | Novartis Ag | Micro-droplet delivery device and methods |
US10806817B2 (en) | 2015-12-10 | 2020-10-20 | Earl Vaughn Sevy | Annular separator apparatus and method |
US11065358B2 (en) | 2016-02-11 | 2021-07-20 | Earl Vaughn Sevy | Air-blade, silencer and separator apparatus and method |
WO2018031693A1 (en) * | 2016-08-09 | 2018-02-15 | Cashman Kathryn | Ampoule for inhalant device |
US11247001B2 (en) * | 2016-09-30 | 2022-02-15 | De Motu Cordis Pty Ltd | Delivery device with cantilever structure and associated method of use |
US11389602B2 (en) * | 2017-07-19 | 2022-07-19 | Flaem Nuova S.P.A. | Nebulization device for medical mixture |
US20210268209A1 (en) * | 2018-07-24 | 2021-09-02 | Monash University | Nebulizer |
CN113543752A (en) * | 2019-03-06 | 2021-10-22 | 科达莱昂治疗公司 | Multi-dose ophthalmic fluid delivery system |
US11679028B2 (en) | 2019-03-06 | 2023-06-20 | Novartis Ag | Multi-dose ocular fluid delivery system |
WO2020181238A1 (en) * | 2019-03-06 | 2020-09-10 | Kedalion Therapeutics, Inc. | Multi-dose ocular fluid delivery system |
US10823438B1 (en) * | 2019-09-05 | 2020-11-03 | Altapure, Llc | Vent bypass system |
US11826327B2 (en) | 2020-04-17 | 2023-11-28 | United Therapeutics Corporation | Treatment for interstitial lung disease |
US20210330621A1 (en) | 2020-04-17 | 2021-10-28 | United Therapeutics Corporation | Treatment for interstitial lung disease |
US11925577B2 (en) | 2020-04-17 | 2024-03-12 | Bausch + Lomb Ireland Limted | Hydrodynamically actuated preservative free dispensing system |
US11938057B2 (en) | 2020-04-17 | 2024-03-26 | Bausch + Lomb Ireland Limited | Hydrodynamically actuated preservative free dispensing system |
TWI747773B (en) * | 2021-03-25 | 2021-11-21 | 心誠鎂行動醫電股份有限公司 | Drug delivery container and atomizing device |
Also Published As
Publication number | Publication date |
---|---|
CA1329083C (en) | 1994-05-03 |
GB2224446B (en) | 1992-09-16 |
AU4398689A (en) | 1990-05-10 |
IT8909552A1 (en) | 1991-04-30 |
GB2224446A (en) | 1990-05-09 |
JPH02243165A (en) | 1990-09-27 |
FR2638362A1 (en) | 1990-05-04 |
IT1236320B (en) | 1993-02-22 |
DE3936248A1 (en) | 1990-05-03 |
GB8922417D0 (en) | 1989-11-22 |
IT8909552A0 (en) | 1989-10-30 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
US4976259A (en) | Ultrasonic nebulizer | |
US3387607A (en) | Apparatus for inhalation therapy | |
US20200185591A1 (en) | Vibration systems and methods | |
JP5694666B2 (en) | Ultrasonic liquid sprayer | |
US5485828A (en) | Portable device for micropulverization generated by ultrasound waves | |
TWI732833B (en) | Smoking device for aerosol-generation, aerosol-generating smoking system, cartridge for smoking devices for aerosol-generation and method for generating an aerosol in a smoking system | |
KR100562725B1 (en) | Sonophoresis method and apparatus | |
KR0152086B1 (en) | Dispensing apparatus | |
US3861386A (en) | Ultrasonic nebulizer | |
TW201943341A (en) | Atomization unit | |
JP2008104966A (en) | Atomizing apparatus and suction device | |
JP2008168222A (en) | Ultrasonic atomizing apparatus | |
JP6682267B2 (en) | Nebulizer and method for manufacturing nebulizer | |
US5716002A (en) | Ultrasonic atomizer | |
CN112617297A (en) | Atomizer and electronic atomization device | |
JP2511119Y2 (en) | Ultrasonic atomizer | |
JPH06277590A (en) | Ultrasonic atomizing device | |
JPH08215308A (en) | Liquid evaporator | |
JPS6077771A (en) | Ultrasonic atomizer |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
AS | Assignment |
Owner name: E.D.L. CORPORATION, 4 EAST YANONALI STREET, SANTA Free format text: ASSIGNMENT OF ASSIGNORS INTEREST.;ASSIGNORS:HIGSON, JAMES R.;D'ALFONSO, DAVID A.;WALLS, ROBERT R.;REEL/FRAME:004988/0321 Effective date: 19881128 Owner name: E.D.L. CORPORATION, A CORP. OF UTAH, CALIFORNIA Free format text: ASSIGNMENT OF ASSIGNORS INTEREST;ASSIGNORS:HIGSON, JAMES R.;D'ALFONSO, DAVID A.;WALLS, ROBERT R.;REEL/FRAME:004988/0321 Effective date: 19881128 Owner name: MOUNTAIN MEDICAL EQUIPMENT, INC., 10488 WEST CENTE Free format text: ASSIGNMENT OF ASSIGNORS INTEREST.;ASSIGNOR:E.D.L. CORPORATION;REEL/FRAME:004988/0324 Effective date: 19881128 Owner name: MOUNTAIN MEDICAL EQUIPMENT, INC., A CORP. OF COLO Free format text: ASSIGNMENT OF ASSIGNORS INTEREST;ASSIGNOR:E.D.L. CORPORATION;REEL/FRAME:004988/0324 Effective date: 19881128 |
|
FPAY | Fee payment |
Year of fee payment: 4 |
|
REMI | Maintenance fee reminder mailed | ||
LAPS | Lapse for failure to pay maintenance fees | ||
FP | Lapsed due to failure to pay maintenance fee |
Effective date: 19981211 |
|
STCH | Information on status: patent discontinuation |
Free format text: PATENT EXPIRED DUE TO NONPAYMENT OF MAINTENANCE FEES UNDER 37 CFR 1.362 |