Recherche Images Maps Play YouTube Actualités Gmail Drive Plus »
Recherche avancée dans les brevets | Historique Web | Connexion

Brevets

Numéro de publicationUS5002048 A
Type de publicationOctroi
Numéro de demande07/449,575
Date de publication26 mars 1991
Date de dépôt12 déc. 1989
Date de priorité
12 déc. 1989
Inventeurs
Cessionnaire d'origine
Classification aux États-Unis
Classification internationale
Classification coopérative
Classification européenne
A61M15/00P
Références
Liens externes
Inhalation device utilizing two or more aerosol containers
US 5002048 A
Résumé

The invention includes an inhalation device for delivering medication from two or more medicinal aerosol containers. An L-shaped housing includes a mouthpiece opening at one end and chambers at the other end for receiving the medicinal aerosol containers.

Revendications
What is claimed is:

1. An inhalation device, comprising:

a housing with a first end having at least two openings, each of said at least two openings adapted to receive an aerosol container containing a medicinal compound;

said housing having a second end with an opening in communication with the outside;

said housing further having a hollow chamber in communication with said opening at said second end and means contiguous with said hollow chamber for discharging the medicinal compound from the aerosol containers through said hollow chamber and out of the opening in the second end in communication with the outside.

2. The inhalation device recited in claim 1 wherein said means for discharging includes individual means for discharging the medicinal compound from each of the aerosol containers.

3. The inhalation device recited in claim 2 further comprising means for dividing said hollow chamber into a plurality of hollow chambers corresponding to the number of said individual discharging means, each of said plurality of hollow chambers being in communication with one of said individual discharging means and said opening at said second end.

4. The inhalation device recited in claim 3 wherein said means for dividing includes a dividing wall extending from a first interior side of said housing to a second interior side of said housing between adjacent of said individual discharging means.

5. The inhalation device recited in claim 4 wherein said dividing wall extends between said individual discharging means and said opening at said second end.

6. An inhalation device, comprising:

a housing having a first end and a second end disposed in an L-shaped relationship, said first end having first and second aligned cavities adapted to receive first and second aerosol containers each of which contain a medicinal component, said first cavity being disposed between said second end and said second cavity;

said second end having an opening in communication with the outside;

said housing further having a hollow chamber in communication with said opening at said second end; and

first means contiguous with said hollow chamber for discharging the medicinal component from the first aerosol container in a first fluid path towards and through said hollow chamber and out of said opening in said second end and second means contiguous with said hollow chamber for discharging the medicinal component in a second fluid path from the second aerosol container towards and through said hollow chamber and out of said opening in said second end.

7. The inhalation device recited in claim 6 wherein said housing further includes means for supporting said first and second means for discharging so that the second fluid path does not intersect said first means for discharging.

8. The inhalation device recited in claim 6 further including means for dividing said hollow chamber into a first chamber that permits communication between said first means for discharging and said opening at said second end and a second chamber that permits communication between said second means for discharging and said opening at said second end.

9. The inhalation device recited in claim 8 wherein said dividing means includes a dividing wall extending from a first interior side of said housing to a second interior side of said housing between said first and second means for discharging.

10. An inhalation device comprising:

a housing having a first end and a second end, said first end having first and second spaced radial extensions thereof, each of said first and second spaced radial extensions having an opening adapted to receive an aerosol container containing a medicinal component;

said second end having an opening in communication with the outside;

said housing further having a hollow chamber in communication with said opening at said second end; and

first means contiguous with said hollow chamber for discharging the medicinal component from the first aerosol container in a first fluid path towards and through said hollow chamber and out of said opening in said second end and second means contiguous with said hollow chamber for discharging the medicinal component in a second fluid path from the second aerosol container towards and through said hollow chamber and out of said opening in said second end.

Description
FIELD OF THE INVENTION

The present invention relates to inhalation devices and, more particularly, relates to inhalation devices for delivering multiple medications.

BACKGROUND OF THE INVENTION

Therapeutic efficiency is often improved by treating patients with a combination of medications. Asthma treatment is representative of such methods; as a rule, a beta-adrenergic product or a cromolyn sodium product is first delivered to dilate the bronchial passageways after which a corticosteroid is administered to reduce inflammation.

Typically, these medications are delivered as inhalational medications. Under conventional practice, a patient uses one metered dose inhaler to deliver the bronchodilator and another metered dose inhaler to deliver the corticosteroid. The practice of using multiple inhalers is inconvenient and burdensome. Often times a patient will misplace one of the inhalers and then simply administer the drug contained in the remaining inhaler with the obvious detriment to therapeutic efficacy resulting. Patients already self-conscious of the fact that they are publicly taking medication are likely to skip scheduled administrations during working or school hours when multiple inhalers have to be utilized. Accordingly, the prior art lacks a single device capable of delivering inhalation medications administered in combination.

SUMMARY OF THE INVENTION

The present invention includes an inhalation device for administering medications from different aerosol containers supported thereon. Two aerosol containers are supported relative to a mouthpiece opening. Respective valve assemblies are provided to direct the metered dose spray towards the mouthpiece upon actuation by the patient. The valve assemblies are positioned so that the aerosolized spray upon discharge passes unimpeded towards the mouthpiece opening. A dividing wall may be provided to separate the fluid paths of different medicinal sprays. In one embodiment, the two aerosol containers are aligned perpendicular to the longitudinal axis of the mouthpiece. In another embodiment, the two aerosol containers extend radially relative to the mouthpiece.

It is a primary object of the present invention to provide an inhalation device for administering medication from multiple aerosol containers.

It is a further object of the present invention to provide an inhalation device that is simple and inexpensive to manufacture.

It is still another object of the present invention to provide an inhalation device that facilitates administration of complementary medications.

BRIEF DESCRIPTION OF THE DRAWING

These and other details and advantages of the invention will be described in connection with the accompanying Drawing in which:

FIG. 1 is a perspective view partly in phantom of the inhalation device according to a preferred embodiment of the invention; and

FIG. 2 is a top view partly in phantom showing an alternative embodiment of the invention.

DESCRIPTION OF THE PREFERRED EMBODIMENT

In the preferred embodiment of the present invention as shown in FIG. 1, the inhalation device 10 includes an L-shaped housing 12 having first and second chambers 14, 16 which may be aligned with one another. Aerosol canisters or containers 18, 20 containing the medicine to be administered are received within the chambers 14, 16. Exit tubes 22, 24 are positioned in the opening of the valve discharge assemblies 26, 28. As is well known to those skilled in the art, displacement of the aerosol container against the valve discharge assemblies will cause the pressurized medication stored in the container to escape through the exit tubes and into the valve assemblies. The valve assemblies discharge the aerosolized medication 30, 31 towards and through the mouthpiece opening 32. Valve assembly 28 is disposed below valve assembly 26 to provide an unobstructed fluid path for the aerosolized medicinal spray to follow towards the mouthpiece opening 32. Chamber 16 is preferably positioned so that container 20 extends to a lesser height than container 18. The distinction in height between the two containers 18, 20 is thought to facilitate the patients recognition of the different medications being actuated. Also having the Beta.sub.2 product appearing in front of the corticosteroid product is believed to further facilitate the patient's recognition as to which medication to take first.

To prevent the aerosolized sprays from mixing prior to administration and to prevent medicinal remnants on the housing inner surface from contaminating subsequent actuations, a dividing wall 34 is preferably disposed between the first and second valve assemblies. The dividing wall 34 extends across the housing 12 from one side to the other and lengthwise at least a sufficient amount to ensure that the aforementioned disadvantages are minimized. The greatest guarantee against deleterious mixing and contamination is achieved by having the dividing wall 34 extend all the way to the mouthpiece opening 32.

In an alternative embodiment shown in FIG. 2 the chambers 50, 52 for receiving the containers holding the pressurized medicine extend radially from the housing 54. To facilitate manufacture of the inhalation device, the valve assemblies 56, 58 are aligned with the chambers 50, 52. Dividing wall 60 is disposed between the valve assemblies 56, 58 to prevent disadvantageous contamination or commingling of the different medications discharged from the first and second containers 62, 64.

Application of complementary medications is facilitated by use of the present invention. A representative example is the treatment of asthma. In the dual chamber inhalation device according to the present invention, one of the aerosol containers holds a bronchodilator such as albuterol while the other aerosol container holds the corticosteroid such as beclomethasone dipropionate. The patient places the mouthpiece into his/her mouth and then depresses the aerosol container holding the albuterol whereby a metered dose of albuterol is discharged from the aerosol container through the exit tube and out of the valve towards and through the mouthpiece opening and into the patients bronchial passageways. After a predetermined period of time in which the albuterol operates to open the bronchial channels, the patient depresses the other aerosol container whereby the beclomethasone dipropionate is administered to the patient via the same route through the inhalation device. The anti-inflammatory corticosteroid can travel deep into the patients bronchial tract by virtue of the prior bronchodilation therapy. Accordingly, increased therapeutic efficiency of the inhaled beclomethasone dipropionate is achieved. Also by using the corticosteroid after the bronchodilator the patient will reduce inflammation and enhance the effectiveness of the subsequent bronchodilator administration. Consequently, using a Beta.sub.2 and an inhaled corticosteroid combination drug regimen optimizes the total therapeutic efficiency of both drugs.

It is to be understood that the preceding description is given merely by way of illustration and not in limitation of the invention and that various modifications may be made thereto without departing from the spirit of the invention as claimed.

Citations de brevets
Brevet cité Date de dépôt Date de publication Déposant Titre
US345159324 juin 196624 juin 1969Colgate Palmolive Co.Pressurized dispensing device
US37047255 janv. 19715 déc. 1972Ciba-Geigy Corp.High pressure propellant dispensing valve
US390886831 mai 197430 sept. 1975Itt CorporationLiquid dispenser
US391634331 juil. 197428 oct. 1975Minolta Camera Kabushiki KaishaFrequency stabilized relaxation oscillator
US392320229 nov. 19732 déc. 1975Ciba-Geigy CorporationNon-spitting liquid dispensing device with pressurized product supply
US42614818 août 197814 avr. 1981General DynamicsFluid packaging kit for pressurized dispensing
US459383610 mai 198410 juin 1986Societe AvitexDouble chamber aerosol container
US479114910 nov. 198613 déc. 1988Dow Corning France S.A.Methods of making dressings
US488759127 juil. 198819 déc. 1989Grace Create Inc.Midget life-saving respirator gas tank apparatus
US495354726 janv. 19894 sept. 1990Greenfield Medical Technologies Inc.Drug administering endotracheal respiration systems
Référencé par
Brevet citant Date de dépôt Date de publication Déposant Titre
US516902931 mai 19918 déc. 1992Societe Francaise d'Aerosols et de BauchageMixing dispenser and method of using same
US53016646 mars 199212 avr. 1994Hansen; Brian N.Methods and apparatus for drug delivery using supercritical solutions
US54372673 août 19931 août 1995Weinstein; AllanDevice for delivering aerosol to the nasal membranes and method of use
US55051944 oct. 19949 avr. 1996Abbott LaboratoriesAerosol inhalation device having slideably and rotatably connected elliptical cylinder portions
US552461324 sept. 199311 juin 1996Habley Medical Technology CorporationControlled multi-pharmaceutical inhaler
US56394418 avr. 199417 juin 1997Board Of Regents Of University Of ColoradoMethods for fine particle formation
US566455727 déc. 19959 sept. 1997Respiratory Delivery Systems, Inc.Releasably engageable coupling for an inhaler
US58304904 avr. 19973 nov. 1998Weinstein; Alan M.Method and device for organizing and coordinating the combined use of topical aerosols and oral medications for the treatment of disorders
US594124112 mai 199724 août 1999Weinstein; Allan M.Method and device for organizing and coordinating the combined use of topical aerosols for the treatment of respiratory disorders
US600674517 mai 199528 déc. 1999Minnesota Mining And Manufacturing CompanyDevice for delivering an aerosol
US609513424 avr. 19971 août 2000The Board Of Regents Of The University Of CoMethods and apparatus for fine particle formation
US652353612 mars 200125 févr. 2003Birdsong Medical Devices, Inc.Dual-canister inhaler having a spacer and easy to operate lever mechanism
US654344312 juil. 20008 avr. 2003Aerogen, Inc.Methods and devices for nebulizing fluids
US66848804 déc. 20013 févr. 2004Hewlett-Packard Development Company, L.P.Applicator for dispensing bioactive compositions and methods for using the same
US669842225 févr. 20022 mars 2004Birdsong Medical Devices, Inc.Canister inhaler having a spacer and easy to operate lever mechanism and a flexible, elastic mouthpiece
US672585914 janv. 199827 avr. 2004Charles River LaboratoriesApparatus for delivering air-borne substances
US681087320 avr. 20002 nov. 2004Innovata Biomed LimitedPowder inhaler for combined medicament
US681087420 avr. 20002 nov. 2004Innovata Biomed LimitedPowder inhaler for combined medicament
US683004629 avr. 200214 déc. 2004Hewlett-Packard Development Company, L.P.Metered dose inhaler
US68457721 déc. 200025 janv. 2005Innovata Biomed LimitedInhaler
US696898218 sept. 200229 nov. 2005Burns Caleb E SMultiple-mist dispenser
US69713859 mai 20036 déc. 2005Flora MaurinoApparatus and method for respiratory drug delivery
US702149921 sept. 20044 avr. 2006Bissell Homecare, Inc.Aerosol package
US702946510 avr. 200318 avr. 2006Pharmacia CorporationFilter ampoule system
US708993426 févr. 200115 août 2006Vectura LimitedDelivery of oral drugs
US719804429 oct. 20033 avr. 2007Hewlett-Packard Development Company, L.P.Applicator for dispensing bioactive compositions and methods for using the same
US72073305 juin 200024 avr. 2007Innovata Biomed LimitedDelivery system
US72196654 sept. 200022 mai 2007Innovata Biomed LimitedDelivery device
US723446418 déc. 200026 juin 2007Meda Pharma Gmbh & Co. Kg.Storage system for powdered pharmaceuticals, and inhaler equipped with this system
US746470422 nov. 200216 déc. 2008Innovata Biomed LimitedMedicament delivery assembly
US75717231 mars 200711 août 2009Innovata Biomed LimitedDelivery device
US75717241 mars 200711 août 2009Innovata Biomed LimitedDelivery device
US768619112 juil. 200530 mars 2010Burns Caleb E SMultiple-mist dispenser
US77263081 nov. 20051 juin 2010Flora MaurinoApparatus and method for respiratory drug delivery
US78498539 févr. 200414 déc. 2010Trudell Medical InternationalVentilator circuit and the method for the use thereof
US79136868 nov. 200529 mars 2011Scadds IncorporatedSelf contained aerosol dual delivery system (SCADDS)
US79310228 oct. 200226 avr. 2011Respirks, Inc.Method and apparatus for dispensing inhalator medicament
US79544929 nov. 20057 juin 2011Almirall, S.A.Pharmaceutical powder cartridge, and inhaler equipped with same
US802869724 avr. 20064 oct. 2011Trudell Medical InternationalVentilator circuit and method for the use thereof
US815179418 avr. 200810 avr. 2012Trudell Medical InternationalAerosol delivery system
US816196821 juil. 200424 avr. 2012Glaxo Group LimitedMedicament dispenser
US820155612 août 200519 juin 2012Glaxo Group LimitedMedicament dispenser
US820561410 août 200926 juin 2012Innovata Biomed LimitedDelivery device
US825508928 mai 201028 août 2012S.C. Johnson & Son, Inc.Multiple volatile material dispensing device and operating methodologies therefore
US837594025 mai 200719 févr. 2013Almirall, S.A.Storage system for powdered pharmaceuticals and inhaler equipped with this system
US2005015449122 janv. 200314 juil. 2005Anderson Gregor J.M.Medicament dispenser
US2008030810113 juin 200818 déc. 2008Idtx Systems, Inc.Drug delivery and monitoring system for a ventilator
US2010007488113 juil. 200925 mars 2010Parion Sciences, Inc.Multiple nebulizer systems
US2011021467123 oct. 20088 sept. 2011Pulmovet ApsInhaler assembly
CN100553705C13 juil. 200728 oct. 2009Canon KkMedicine ejection apparatus
EP1317939A214 nov. 200211 juin 2003Hewlett-Packard CompanyApplicator for dispensing bioactive compositions and methods for using the same
EP1878455A13 juil. 200716 janv. 2008Canon Kabushiki KaishaMethod for controlling ejection of medicines and medicine ejection apparatus
WO1992016249A121 mars 19911 oct. 1992Weinstein, AllanInhaler device
WO1996022119A11 déc. 199525 juil. 1996Dwork, PaulMetered dose medication adaptor with improved incentive spirometer
WO2002004055A127 juin 200117 janv. 2002Aerogen, Inc.Methods and devices for nebulizing fluids
WO2002066009A17 févr. 200229 août 2002Aeropharm Technology, Inc.Modulated release particles for aerosol delivery
WO2002066010A16 févr. 200229 août 2002Aeropharm Technology, Inc.Modulated release particles for aerosol delivery
WO2003061744A122 janv. 200331 juil. 2003Bonney, Stanley, GeorgeMedicament dispenser
WO2003086268A110 avr. 200323 oct. 2003Carpenter, PeterFile ampoule system
WO2004011069A123 juil. 20035 févr. 2004Davies, Michael, BirshaMedicament dispenser
WO2004011070A123 juil. 20035 févr. 2004Bonney, Stanley, GeorgeMedicament dispenser
WO2006114699A226 avr. 20062 nov. 2006Trudell Medical InternationalVentilator circuit and method for the use thereof
WO2009052563A123 oct. 200830 avr. 2009Funch Nielsen, HelleInhaler assembly
WO2012032010A15 sept. 201115 mars 2012Chiesi Farmaceutici S.P.A.Metered-dose inhaler and method of using the same