US5464122A - Non-streaming ophthalmic tip and delivery device - Google Patents

Non-streaming ophthalmic tip and delivery device Download PDF

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Publication number
US5464122A
US5464122A US08/265,351 US26535194A US5464122A US 5464122 A US5464122 A US 5464122A US 26535194 A US26535194 A US 26535194A US 5464122 A US5464122 A US 5464122A
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United States
Prior art keywords
tip
cap
barrier
channel
ophthalmic
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Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
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US08/265,351
Inventor
Arthur L. Lifshey
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Merck Sharp and Dohme LLC
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Merck and Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck and Co Inc filed Critical Merck and Co Inc
Priority to US08/265,351 priority Critical patent/US5464122A/en
Assigned to MERCK & CO., INC. reassignment MERCK & CO., INC. ASSIGNMENT OF ASSIGNORS INTEREST (SEE DOCUMENT FOR DETAILS). Assignors: LIFSHEY, ARTHUR L.
Priority to ES95924607T priority patent/ES2164156T3/en
Priority to PCT/US1995/007708 priority patent/WO1996000173A1/en
Priority to EP95924607A priority patent/EP0765276B1/en
Priority to AT95924607T priority patent/ATE207442T1/en
Priority to DE69523454T priority patent/DE69523454T2/en
Priority to JP50325596A priority patent/JP3490090B2/en
Priority to CA002193245A priority patent/CA2193245C/en
Priority to AU29039/95A priority patent/AU689918B2/en
Publication of US5464122A publication Critical patent/US5464122A/en
Application granted granted Critical
Assigned to MERCK SHARP & DOHME CORP. reassignment MERCK SHARP & DOHME CORP. CHANGE OF NAME (SEE DOCUMENT FOR DETAILS). Assignors: MERCK & CO., INC.
Assigned to SCHERING CORPORATION reassignment SCHERING CORPORATION MERGER (SEE DOCUMENT FOR DETAILS). Assignors: MERCK SHARP & DOHME CORP.
Assigned to MERCK SHARP & DOHME CORP. reassignment MERCK SHARP & DOHME CORP. CHANGE OF NAME (SEE DOCUMENT FOR DETAILS). Assignors: SCHERING CORPORATION
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

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Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
    • B65D—CONTAINERS FOR STORAGE OR TRANSPORT OF ARTICLES OR MATERIALS, e.g. BAGS, BARRELS, BOTTLES, BOXES, CANS, CARTONS, CRATES, DRUMS, JARS, TANKS, HOPPERS, FORWARDING CONTAINERS; ACCESSORIES, CLOSURES, OR FITTINGS THEREFOR; PACKAGING ELEMENTS; PACKAGES
    • B65D51/00—Closures not otherwise provided for
    • B65D51/18—Arrangements of closures with protective outer cap-like covers or of two or more co-operating closures
    • B65D51/20—Caps, lids, or covers co-operating with an inner closure arranged to be opened by piercing, cutting, or tearing
    • B65D51/22—Caps, lids, or covers co-operating with an inner closure arranged to be opened by piercing, cutting, or tearing having means for piercing, cutting, or tearing the inner closure
    • B65D51/221—Caps, lids, or covers co-operating with an inner closure arranged to be opened by piercing, cutting, or tearing having means for piercing, cutting, or tearing the inner closure a major part of the inner closure being left inside the container after the opening
    • B65D51/222—Caps, lids, or covers co-operating with an inner closure arranged to be opened by piercing, cutting, or tearing having means for piercing, cutting, or tearing the inner closure a major part of the inner closure being left inside the container after the opening the piercing or cutting means being integral with, or fixedly attached to, the outer closure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F9/00—Methods or devices for treatment of the eyes; Devices for putting-in contact lenses; Devices to correct squinting; Apparatus to guide the blind; Protective devices for the eyes, carried on the body or in the hand
    • A61F9/0008—Introducing ophthalmic products into the ocular cavity or retaining products therein
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
    • B65D—CONTAINERS FOR STORAGE OR TRANSPORT OF ARTICLES OR MATERIALS, e.g. BAGS, BARRELS, BOTTLES, BOXES, CANS, CARTONS, CRATES, DRUMS, JARS, TANKS, HOPPERS, FORWARDING CONTAINERS; ACCESSORIES, CLOSURES, OR FITTINGS THEREFOR; PACKAGING ELEMENTS; PACKAGES
    • B65D2251/00—Details relating to container closures
    • B65D2251/0003—Two or more closures
    • B65D2251/0006—Upper closure
    • B65D2251/0015—Upper closure of the 41-type
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
    • B65D—CONTAINERS FOR STORAGE OR TRANSPORT OF ARTICLES OR MATERIALS, e.g. BAGS, BARRELS, BOTTLES, BOXES, CANS, CARTONS, CRATES, DRUMS, JARS, TANKS, HOPPERS, FORWARDING CONTAINERS; ACCESSORIES, CLOSURES, OR FITTINGS THEREFOR; PACKAGING ELEMENTS; PACKAGES
    • B65D2251/00—Details relating to container closures
    • B65D2251/0003—Two or more closures
    • B65D2251/0068—Lower closure
    • B65D2251/0093—Membrane
    • B65D2251/0096—Membrane integral with the container

Definitions

  • This invention relates to a liquid dispensing tip and cap especially useful in the dispensing of ophthalmic drugs which typically need to be dispensed in the form of a drop, and a novel method of manufacturing it.
  • the present invention pertains to the art of liquid dispensers, and, more particularly, to a dispensing tip for accurately dispensing small droplets of liquid.
  • the invention is particularly applicable for use as an eyedropper to dispense ophthalmic drugs and will be described with particular reference thereto although it will be appreciated that the invention has other and broader applications.
  • Medicant drop dispensers of the type to which the present invention pertains are available in various sizes and shapes for the numerous medicines and solutions which are available for the care and comfort of the human eye.
  • Such dispensers are basically comprised of a relatively small compressible plastic container or vial provided with a dispensing tip and cap.
  • One problem associated with conventional eyedroppers is the difficulty in accurately controlling the amount of medicine dispensed, i.e., the number of drops dispensed.
  • Many conventional eyedroppers utilize one or a combination of methods to achieve single drop control.
  • One method uses a highly compliant plastic bottle which the user squeezes to dispense a drop.
  • the extensive deflection of the bottle creates an significant internal air pressure within the vial which expels the liquid through the tip.
  • these bottles sometimes incorporate a flow restriction at the inlet of the tip or nozzle. This flow restriction tends to limit the number of drops expelled during a single squeeze. It limits the liquid medicant flow rate favoring the formation of individual drops releasing from the dropper tip rather than a continuous stream.
  • the present invention contemplates a new and improved tip and cap for ophthalmic use, which overcomes the above-referred to manufacturing difficulties and which accurately dispenses droplets of liquid medicant at desired locations as discrete drops.
  • Single drops having a volume of approximately 30-50 microliters are typical in the art, but larger or smaller drops, can be provided by adjusting size and geometry of the tip.
  • an improved tip, or drop dispenser for use with a closed compressible container.
  • the preferred tip is integrated into a simple one piece molded device, together with a mated cap in combination which is best understood by reference to the accompanying drawings.
  • the tip/cap combination also serves as a means for providing an hermetically sealed tip which can be activated (opened) only when ready for use. This can be accomplished by only partially assembling the cap onto the tip, so s that the cap (2) does not displace the membrane in the tip. The tip thus remains hermetically sealed, eliminating the possibility of minor leaks of liquid or vapor during long storage periods.
  • FIG. 1 is a vertical sectional view of the one-piece molded tip having a cap with screw threads engaged around the tip.
  • FIG. 2 is a cross-section of FIG. 1 taken along line 2--2, showing a restricted flow channel side slot.
  • FIGS. 2a and 2b are alternate embodiments showing other restricted slot(s) or groove(s).
  • FIGS. 3 and 4 are vertical sectional views of the tip showing the action in opening the cap and the restricted flow path, which prevents streaming.
  • FIG. 5 is a diagrammatic view of an example of an ophthalmic container having the tip with cap of this invention in place.
  • the actual bottle design is not a critical part of this invention. Any of the ophthalmic containers presently available can be used with the tip of this invention.
  • the bottle design illustrated, which is especially preferred, is one having a limited displacement area, such as described in the invention claimed in U.S. Ser. No. 08/200,076, filed Dec. 22, 1993.
  • the ophthalmic tip shown generally at 1
  • a cap 2 attached through screw threads 3.
  • the bottle which can be any type bottle useful for dispensing ophthalmic medicaments, is indicated generally at 4.
  • the cap 2 serves as a "seal-break".
  • the tip is formed with a dislodgeable barrier 5 across the opening.
  • the embodiment shown is eliptically shaped, and slanted so that it is attached higher inside the tip, at a point above a side slot 8.
  • Other embodiments can include a circular or spherical barrier attached at circumferentially to the inside wall of the tip 1.
  • the inside of the cap 2 fitting over the nozzle opening is fitted with a suitably sized and shaped integrally molded stud 6.
  • the cap 2 can be designed so that a final clockwise half-turn of the cap pushes the stud 6 against the barrier 5 and downwardly displaces it while it remains attached at hinge point 9 to inside wall 7.
  • the cap and bottle may be so designed so that the stud 6 is moved downward against barrier 5 by axial force applied to the cap.
  • Another embodiment of this invention would have stud 6 completely dislodge barrier 5 with a new position, which would break the hermetic seal and create a suitable flow restriction.
  • the barrier would be captivated in its new open position by friction fit, undercuts, or other mechanical means, allowing it to function as a flow restrictor able to resist the internal pressure generated in the vial during dispensing.
  • the slot 8 in FIG. 2 may be of various sizes to allow for flow characteristics and viscosity of diverse fluids. Slot 8 may also consist of any number of shallow slots, as dictated by the flow properties.
  • the restricted flow channel side slot 8 or slots is an important part of this invention, as it serves to aid in the prevention of a stream of medicament.
  • cap 2 Once the cap 2 is pushed or screwed down onto the tip 1, and the barrier 5 is displaced downwardly, the liquid contents can exit through the side slot 8 by flowing around the barrier 5, as shown in FIG. 4, which is an upside-down vertical section.
  • the arrow 10 in FIG. 4 demonstrates the fluid path flow.
  • the stud 6 of cap 2 is designed so that the stud 6 serves as a leak-proof closure for the bottle upon recapping after activation.
  • the restricted flow channel side slot 8 is formed during the injection molding process by using a small radially outward projection on a relatively large sturdy core pin.
  • the ophthalmic dispensing tip and cap of this invention can be injection molded of a suitable plastic, such as polyethylene or polypropylene.
  • the tip of this invention is molded as part of a bottle having a limited displacement side member as illustrated in FIG. 5.
  • the combination of a limited displacement bottle and the flow restriction in the instant dispensing tip are a way to prevent streaming.
  • FIG. 5 is a diagrammatic view of this embodiment of the ophthalmic container including the tip and cap of the instant invention.
  • the invention of the bottle of FIG. 5 is an independent invention, previously filed on Dec. 22, 1993, U.S. Ser. No. 08/200,676.
  • FIG. 5 shows the tip and cap of the present invention in place on the bottle of the independent invention, comprised of a compressible plastic container or vial 20, a cap member 21, and a bottom closure 22.
  • Container or vial 20 contains a supply of liquid 23, medicament for instance, to be dispensed in droplet form.
  • the container 20 has an integral reduced diameter open neck portion 24 provided with external helical screw threads 25 over the uppermost part of the neck end portion as shown in FIG. 5.
  • the screw threads 25 are adapted to matingly engage internal threads 26 on cap member 21 to thereby attach the latter in place on container 20 in liquid-tight relation thereto.
  • Cap member 21 comprises a generally cylindrical mounting or base portion 27 and a inside nozzle end portion stud 28 projecting endwise therefrom.

Abstract

This invention consists of an ophthalmic dispensing tip formed by injection molding, which has a one-piece molded tip to be used with a mating cap, the tip having an internally molded breakaway barrier membrane inside the flow channel, and the cap having a shaped stud fitting inside the tip, so that the final clockwise half-turn of the cap pushes the stud against the barrier and displaces it, thereby creating a restricted path through which the contents are dispensed.

Description

TECHNICAL HELD
This invention relates to a liquid dispensing tip and cap especially useful in the dispensing of ophthalmic drugs which typically need to be dispensed in the form of a drop, and a novel method of manufacturing it.
BACKGROUND OF THE INVENTION
The present invention pertains to the art of liquid dispensers, and, more particularly, to a dispensing tip for accurately dispensing small droplets of liquid. The invention is particularly applicable for use as an eyedropper to dispense ophthalmic drugs and will be described with particular reference thereto although it will be appreciated that the invention has other and broader applications.
Medicant drop dispensers of the type to which the present invention pertains are available in various sizes and shapes for the numerous medicines and solutions which are available for the care and comfort of the human eye. Such dispensers are basically comprised of a relatively small compressible plastic container or vial provided with a dispensing tip and cap.
One problem associated with conventional eyedroppers is the difficulty in accurately controlling the amount of medicine dispensed, i.e., the number of drops dispensed. Many conventional eyedroppers utilize one or a combination of methods to achieve single drop control.
One method uses a highly compliant plastic bottle which the user squeezes to dispense a drop. The extensive deflection of the bottle creates an significant internal air pressure within the vial which expels the liquid through the tip. In order to prevent a continuous stream of liquid medicant from being expelled, and to create single drops, these bottles sometimes incorporate a flow restriction at the inlet of the tip or nozzle. This flow restriction tends to limit the number of drops expelled during a single squeeze. It limits the liquid medicant flow rate favoring the formation of individual drops releasing from the dropper tip rather than a continuous stream. Unfortunately, the creation of a very small molded orifice, frequently as small as 0.005" (0.13 mm) in diameter creates manufacturing difficulties, since the plastic injection molds must have corresponding small fragile (0.005" dia./0.13 mm dia.) core pins.
SUMMARY OF THE INVENTION
The present invention contemplates a new and improved tip and cap for ophthalmic use, which overcomes the above-referred to manufacturing difficulties and which accurately dispenses droplets of liquid medicant at desired locations as discrete drops. Single drops having a volume of approximately 30-50 microliters are typical in the art, but larger or smaller drops, can be provided by adjusting size and geometry of the tip.
In accordance with the present invention there is provided an improved tip, or drop dispenser for use with a closed compressible container. The preferred tip is integrated into a simple one piece molded device, together with a mated cap in combination which is best understood by reference to the accompanying drawings. The tip/cap combination also serves as a means for providing an hermetically sealed tip which can be activated (opened) only when ready for use. This can be accomplished by only partially assembling the cap onto the tip, so s that the cap (2) does not displace the membrane in the tip. The tip thus remains hermetically sealed, eliminating the possibility of minor leaks of liquid or vapor during long storage periods.
FIG. 1 is a vertical sectional view of the one-piece molded tip having a cap with screw threads engaged around the tip.
FIG. 2 is a cross-section of FIG. 1 taken along line 2--2, showing a restricted flow channel side slot. FIGS. 2a and 2b are alternate embodiments showing other restricted slot(s) or groove(s).
FIGS. 3 and 4 are vertical sectional views of the tip showing the action in opening the cap and the restricted flow path, which prevents streaming.
FIG. 5 is a diagrammatic view of an example of an ophthalmic container having the tip with cap of this invention in place.
The actual bottle design is not a critical part of this invention. Any of the ophthalmic containers presently available can be used with the tip of this invention. The bottle design illustrated, which is especially preferred, is one having a limited displacement area, such as described in the invention claimed in U.S. Ser. No. 08/200,076, filed Dec. 22, 1993.
Referring to the drawings, the key aspects of this invention are described as follows.
In FIG. 1, the ophthalmic tip, shown generally at 1, is protected by a cap 2, attached through screw threads 3. The bottle, which can be any type bottle useful for dispensing ophthalmic medicaments, is indicated generally at 4.
The cap 2 serves as a "seal-break". The tip is formed with a dislodgeable barrier 5 across the opening. The embodiment shown is eliptically shaped, and slanted so that it is attached higher inside the tip, at a point above a side slot 8. Other embodiments can include a circular or spherical barrier attached at circumferentially to the inside wall of the tip 1. The inside of the cap 2 fitting over the nozzle opening is fitted with a suitably sized and shaped integrally molded stud 6. The cap 2 can be designed so that a final clockwise half-turn of the cap pushes the stud 6 against the barrier 5 and downwardly displaces it while it remains attached at hinge point 9 to inside wall 7. Alternatively, the cap and bottle may be so designed so that the stud 6 is moved downward against barrier 5 by axial force applied to the cap. Another embodiment of this invention would have stud 6 completely dislodge barrier 5 with a new position, which would break the hermetic seal and create a suitable flow restriction. In all cases, the barrier would be captivated in its new open position by friction fit, undercuts, or other mechanical means, allowing it to function as a flow restrictor able to resist the internal pressure generated in the vial during dispensing. Alternatively, the slot 8 in FIG. 2 may be of various sizes to allow for flow characteristics and viscosity of diverse fluids. Slot 8 may also consist of any number of shallow slots, as dictated by the flow properties.
The restricted flow channel side slot 8 or slots is an important part of this invention, as it serves to aid in the prevention of a stream of medicament.
Its shape in cross section is shown in FIGS. 2, and alterative embodiments 2A and 2B wherein it can clearly be seen as molded slot(s) or groove(s) in the nozzle channel.
Once the cap 2 is pushed or screwed down onto the tip 1, and the barrier 5 is displaced downwardly, the liquid contents can exit through the side slot 8 by flowing around the barrier 5, as shown in FIG. 4, which is an upside-down vertical section. The arrow 10 in FIG. 4 demonstrates the fluid path flow. The stud 6 of cap 2 is designed so that the stud 6 serves as a leak-proof closure for the bottle upon recapping after activation.
The restricted flow channel side slot 8 is formed during the injection molding process by using a small radially outward projection on a relatively large sturdy core pin.
The ophthalmic dispensing tip and cap of this invention can be injection molded of a suitable plastic, such as polyethylene or polypropylene.
In one preferred embodiment, the tip of this invention is molded as part of a bottle having a limited displacement side member as illustrated in FIG. 5. The combination of a limited displacement bottle and the flow restriction in the instant dispensing tip are a way to prevent streaming. FIG. 5 is a diagrammatic view of this embodiment of the ophthalmic container including the tip and cap of the instant invention. As noted, the invention of the bottle of FIG. 5 is an independent invention, previously filed on Dec. 22, 1993, U.S. Ser. No. 08/200,676.
FIG. 5 shows the tip and cap of the present invention in place on the bottle of the independent invention, comprised of a compressible plastic container or vial 20, a cap member 21, and a bottom closure 22. Container or vial 20 contains a supply of liquid 23, medicament for instance, to be dispensed in droplet form. The container 20 has an integral reduced diameter open neck portion 24 provided with external helical screw threads 25 over the uppermost part of the neck end portion as shown in FIG. 5. The screw threads 25 are adapted to matingly engage internal threads 26 on cap member 21 to thereby attach the latter in place on container 20 in liquid-tight relation thereto.
Cap member 21 comprises a generally cylindrical mounting or base portion 27 and a inside nozzle end portion stud 28 projecting endwise therefrom.

Claims (1)

What is claimed is:
1. An ophthalmic tip and cap system providing non-streaming drop control, the tip having an internally molded dislodgeable barrier attached inside the channel of the tip at a slant, the higher point of attachment being above a side slot in said channel; and the lower point of attachment being opposite said slot; the cap having a stud shaped to fit inside said channel, so that the downward axial movement of the cap displaces the barrier downward from the higher point of attachment in said channel, said barrier remaining attached inside said channel at the lower point of attachment.
US08/265,351 1994-06-24 1994-06-24 Non-streaming ophthalmic tip and delivery device Expired - Lifetime US5464122A (en)

Priority Applications (9)

Application Number Priority Date Filing Date Title
US08/265,351 US5464122A (en) 1994-06-24 1994-06-24 Non-streaming ophthalmic tip and delivery device
JP50325596A JP3490090B2 (en) 1994-06-24 1995-06-22 Eye drops and eye drops that do not flow out
AU29039/95A AU689918B2 (en) 1994-06-24 1995-06-22 Non-streaming ophthalmic tip and delivery device
EP95924607A EP0765276B1 (en) 1994-06-24 1995-06-22 Non-streaming ophthalmic tip and delivery device
AT95924607T ATE207442T1 (en) 1994-06-24 1995-06-22 OPHTHALMOLOGICAL DISPENSING TIP AND DROP-WISE DISPENSING DEVICE
DE69523454T DE69523454T2 (en) 1994-06-24 1995-06-22 OPHTHALMOLOGICAL DISPENSING TIP AND DISCHARGE DISPENSER
ES95924607T ES2164156T3 (en) 1994-06-24 1995-06-22 DISTRIBUTING NOZZLE FOR OPHTHALMIC PREPARATION THAT DOES NOT FORM A CONTINUOUS CURRENT AND ASSOCIATED DISTRIBUTING DEVICE.
CA002193245A CA2193245C (en) 1994-06-24 1995-06-22 Non-streaming ophthalmic tip and delivery device
PCT/US1995/007708 WO1996000173A1 (en) 1994-06-24 1995-06-22 Non-streaming ophthalmic tip and delivery device

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US08/265,351 US5464122A (en) 1994-06-24 1994-06-24 Non-streaming ophthalmic tip and delivery device

Publications (1)

Publication Number Publication Date
US5464122A true US5464122A (en) 1995-11-07

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Application Number Title Priority Date Filing Date
US08/265,351 Expired - Lifetime US5464122A (en) 1994-06-24 1994-06-24 Non-streaming ophthalmic tip and delivery device

Country Status (9)

Country Link
US (1) US5464122A (en)
EP (1) EP0765276B1 (en)
JP (1) JP3490090B2 (en)
AT (1) ATE207442T1 (en)
AU (1) AU689918B2 (en)
CA (1) CA2193245C (en)
DE (1) DE69523454T2 (en)
ES (1) ES2164156T3 (en)
WO (1) WO1996000173A1 (en)

Cited By (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5609273A (en) * 1995-03-03 1997-03-11 Allergan, Inc. Barrier packaging and materials therefor
US5797506A (en) * 1997-01-27 1998-08-25 Amway Corporation Closure with seal opening member
USD423355S (en) * 1998-09-08 2000-04-25 Thatcher Tubes Llc Applicator tube head
US20040210203A1 (en) * 2001-10-31 2004-10-21 Yukio Kusu Instillation container with level-difference portion
EP1518525A1 (en) 2003-09-26 2005-03-30 Shinko Chemical Co., Ltd. A droplet nozzle for use in eye drop container
US20060191959A1 (en) * 2003-03-11 2006-08-31 Davies Michael B Fluid dispensing device with stopper
WO2007022653A1 (en) * 2005-08-25 2007-03-01 Riwisa Ag Gas-tight spout closure with opening device
US20070251537A1 (en) * 2005-08-29 2007-11-01 L'oreal Product application device
CN100353930C (en) * 1999-08-17 2007-12-12 参天制药株式会社 Open instillation container and method of manufacturing container
US20140376984A1 (en) * 2013-06-24 2014-12-25 HCT Group Holdings Limited Dispenser with threaded tip/dispenser with removable cap
WO2016124683A1 (en) * 2015-02-04 2016-08-11 Alpla Werke Alwin Lehner Gmbh & Co. Kg Pouring-out element
DE102018124067A1 (en) * 2018-09-28 2020-04-02 Gerresheimer Regensburg Gmbh Device for storing and dispensing a sterile fluid
US20220402660A1 (en) * 2021-06-21 2022-12-22 Sulzer Mixpac Ag Liquid applicator
US11641923B2 (en) * 2018-11-07 2023-05-09 HCT Group Holdings Limited Cosmetic container with a capped seal

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US6098852A (en) * 1999-01-27 2000-08-08 Automatic Liquid Packaging, Inc. Tip for liquid drop dispensing container
DE102008034831A1 (en) * 2008-07-26 2010-01-28 Brämig, Sabine Bottle dispenser has container with base, with which container is arranged on horizontal level in its stoppage position, and liquid is filled in container
CA3133645A1 (en) 2019-03-28 2020-10-01 Howard L. Golub Devices and methods for flow control of ophthalmic formulations

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US2411435A (en) * 1943-01-08 1946-11-19 Kirschenbaum Samuel Liquid dispensing device
US2671577A (en) * 1951-03-09 1954-03-09 Peerless Tube Company Collapsible tube with easily rupturable neck diaphragm
US3454196A (en) * 1967-07-20 1969-07-08 Polytop Corp Fixed spout closure with auxiliary cap
DE2906818A1 (en) * 1978-05-03 1979-11-08 Jenapharm Veb LOCKING COMBINATION
EP0228751A2 (en) * 1985-12-31 1987-07-15 LAMEPLAST S.r.l. Piercing closure capsule for droppers or the like
US5052589A (en) * 1990-02-08 1991-10-01 Cp Packaging, Inc. Unit dose assembly

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US2411435A (en) * 1943-01-08 1946-11-19 Kirschenbaum Samuel Liquid dispensing device
US2671577A (en) * 1951-03-09 1954-03-09 Peerless Tube Company Collapsible tube with easily rupturable neck diaphragm
US3454196A (en) * 1967-07-20 1969-07-08 Polytop Corp Fixed spout closure with auxiliary cap
DE2906818A1 (en) * 1978-05-03 1979-11-08 Jenapharm Veb LOCKING COMBINATION
EP0228751A2 (en) * 1985-12-31 1987-07-15 LAMEPLAST S.r.l. Piercing closure capsule for droppers or the like
US5052589A (en) * 1990-02-08 1991-10-01 Cp Packaging, Inc. Unit dose assembly

Cited By (27)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5799837A (en) * 1995-03-03 1998-09-01 Allergan Barrier packaging and materials therefor
US5609273A (en) * 1995-03-03 1997-03-11 Allergan, Inc. Barrier packaging and materials therefor
US5797506A (en) * 1997-01-27 1998-08-25 Amway Corporation Closure with seal opening member
USD423355S (en) * 1998-09-08 2000-04-25 Thatcher Tubes Llc Applicator tube head
CN100353930C (en) * 1999-08-17 2007-12-12 参天制药株式会社 Open instillation container and method of manufacturing container
US7438704B1 (en) 1999-08-17 2008-10-21 Santen Pharmaceutical Co., Ltd. Open instillation container and method of manufacturing the container
US20040210203A1 (en) * 2001-10-31 2004-10-21 Yukio Kusu Instillation container with level-difference portion
US7503909B2 (en) 2001-10-31 2009-03-17 Santen Pharmaceutical Co., Ltd. Instillation container with level-difference portion
US7854352B2 (en) * 2003-03-11 2010-12-21 Glaxo Group Limited Fluid dispensing device with stopper
US20060191959A1 (en) * 2003-03-11 2006-08-31 Davies Michael B Fluid dispensing device with stopper
US20050087572A1 (en) * 2003-09-26 2005-04-28 Shinko Chemical Co., Ltd. Droplet nozzle for use in eye drop container
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ATE207442T1 (en) 2001-11-15
WO1996000173A1 (en) 1996-01-04
CA2193245A1 (en) 1996-01-04
DE69523454T2 (en) 2002-04-18
EP0765276A1 (en) 1997-04-02
DE69523454D1 (en) 2001-11-29
ES2164156T3 (en) 2002-02-16
EP0765276B1 (en) 2001-10-24
JP3490090B2 (en) 2004-01-26
AU2903995A (en) 1996-01-19
EP0765276A4 (en) 1998-12-02
AU689918B2 (en) 1998-04-09
CA2193245C (en) 2008-03-18
JPH10502037A (en) 1998-02-24

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