US5516637A - Method involving display of protein binding pairs on the surface of bacterial pili and bacteriophage - Google Patents
Method involving display of protein binding pairs on the surface of bacterial pili and bacteriophage Download PDFInfo
- Publication number
- US5516637A US5516637A US08/258,026 US25802694A US5516637A US 5516637 A US5516637 A US 5516637A US 25802694 A US25802694 A US 25802694A US 5516637 A US5516637 A US 5516637A
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- United States
- Prior art keywords
- bacteriophage
- protein
- specific binding
- dna
- phage
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- Expired - Fee Related
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- C—CHEMISTRY; METALLURGY
- C40—COMBINATORIAL TECHNOLOGY
- C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
- C40B40/00—Libraries per se, e.g. arrays, mixtures
- C40B40/02—Libraries contained in or displayed by microorganisms, e.g. bacteria or animal cells; Libraries contained in or displayed by vectors, e.g. plasmids; Libraries containing only microorganisms or vectors
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
- C07K14/24—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Enterobacteriaceae (F), e.g. Citrobacter, Serratia, Proteus, Providencia, Morganella, Yersinia
- C07K14/245—Escherichia (G)
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
- C12N15/1034—Isolating an individual clone by screening libraries
- C12N15/1037—Screening libraries presented on the surface of microorganisms, e.g. phage display, E. coli display
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/70—Vectors or expression systems specially adapted for E. coli
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/02—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving viable microorganisms
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/70—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving virus or bacteriophage
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
- C07K2319/02—Fusion polypeptide containing a localisation/targetting motif containing a signal sequence
Abstract
Description
__________________________________________________________________________ SEQUENCE LISTING (1) GENERAL INFORMATION: (iii) NUMBER OF SEQUENCES: 26 (2) INFORMATION FOR SEQ ID NO:1: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 35 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: unknown (D) TOPOLOGY: unknown (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1: GGGGGGAATTC TATCCGAAATTGAGGTAACTTATG35 (2) INFORMATION FOR SEQ ID NO:2: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 39 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: unknown (D) TOPOLOGY: unknown (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2: GGGGGGTCTAGATTAT CAGAGGCCAACGACGGCCATAAC39 (2) INFORMATION FOR SEQ ID NO:3: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 41 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: unknown (D) TOPOLOGY: unknown (xi) SEQUENCE DESCRIPTION: SEQ ID NO:3: GGGGGGATCCCCATGGCCAG CTGCGGGAAGAACATCATCAG41 (2) INFORMATION FOR SEQ ID NO:4: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 40 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: unknown (D) TOPOLOGY: unknown (xi) SEQUENCE DESCRIPTION: SEQ ID NO:4: GGGGGGATCCGGCGCCGGCAGCAGT GGTCAGGACCTGATG40 (2) INFORMATION FOR SEQ ID NO:5: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 33 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: unknown (D) TOPOLOGY: unknown (xi) SEQUENCE DESCRIPTION: SEQ ID NO:5: CACTTGGCCATGGCCGAGGTTCAGCTGCAG CAG33 (2) INFORMATION FOR SEQ ID NO:6: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 34 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: unknown (D) TOPOLOGY: unknown (xi) SEQUENCE DESCRIPTION: SEQ ID NO:6: GCTGCCACCGCCACCTGAGGAGACGGTGACTGAG 34 (2) INFORMATION FOR SEQ ID NO:7: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 35 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: unknown (D) TOPOLOGY: unknown (xi) SEQUENCE DESCRIPTION: SEQ ID NO:7: GGAGGCGGCGGTTCTGATATTGTGATGACTCAGGC 35 (2) INFORMATION FOR SEQ ID NO:8: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 40 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: unknown (D) TOPOLOGY: unknown (xi) SEQUENCE DESCRIPTION: SEQ ID NO:8: TTCATAGGCGGCCGCACTAGTAGCMCGTTTCAGYTCCARC 40 (2) INFORMATION FOR SEQ ID NO:9: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 33 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: unknown (D) TOPOLOGY: unknown (xi) SEQUENCE DESCRIPTION: SEQ ID NO:9: GCCGGCCATGGCCCAGGTBCARCTKMARSARTC 33 (2) INFORMATION FOR SEQ ID NO:10: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 35 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: unknown (D) TOPOLOGY: unknown (xi) SEQUENCE DESCRIPTION: SEQ ID NO:10: GCTGCCACCGCCACCTGMRGAGACDGTGASTGARG 35 (2) INFORMATION FOR SEQ ID NO:11: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 35 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: unknown (D) TOPOLOGY: unknown (xi) SEQUENCE DESCRIPTION: SEQ ID NO:11: GGAGGCGGCGGTTCTGACATTGTGMTGWCACAGTC 35 (2) INFORMATION FOR SEQ ID NO:12: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 40 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: unknown (D) TOPOLOGY: unknown (xi) SEQUENCE DESCRIPTION: SEQ ID NO:12: TTCATAGGCGGCCGCACTAGTAGCMCGTTTKATYTCCARC 40 (2) INFORMATION FOR SEQ ID NO:13: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 45 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: unknown (D) TOPOLOGY: unknown (xi) SEQUENCE DESCRIPTION: SEQ ID NO:13: GGTGGCGGTGGCAGCGGCGGTGGTGGTTCCGGAGGCGGCGGTTCT45 (2) INFORMATION FOR SEQ ID NO:14: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 45 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: unknown (D) TOPOLOGY: unknown (xi) SEQUENCE DESCRIPTION: SEQ ID NO:14: AGAACCGCCGCCTCCGGAAGGAGGACCGCCGCTGCCACCGCCACC45 (2) INFORMATION FOR SEQ ID NO:15: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 53 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: unknown (D) TOPOLOGY: unknown (xi) SEQUENCE DESCRIPTION: SEQ ID NO:15: CATGGCGGCCGGCAGCGCGGCCGCTGAGGAAGAAGAGTACATGCCGATGGAAC53 (2) INFORMATION FOR SEQ ID NO:16: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 53 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: unknown (D) TOPOLOGY: unknown (xi) SEQUENCE DESCRIPTION: SEQ ID NO:16: GCGCCTTCCATCGGCATGTACTCTTCTTCCTCAGCGGCCGCGCTGCCGGCCGC53 (2) INFORMATION FOR SEQ ID NO:17: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 540 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: unknown (D) TOPOLOGY: unknown (xi) SEQUENCE DESCRIPTION: SEQ ID NO:17: GAAACAGCTATGACCATGATTACGAATTCTATCCGAAATTGAGGTAACTTATGAATGCTG60 TTTTAAGTGTTCAGG GTGCTTCTGCGCCCGTCAAAAAGAAGTCGTTTTTTTCCAAATTCA120 CTCGTCTGAATATGCTTCGCCTGGCTCGCGCAGTGATCCCGGCTGCTGTTCTGATGATGT180 TCTTCCCGCAGCTGGCCATGGCGGCCGGCAGCGCGGCCGCTGAGGAAGAAGAGTACATG C240 CGATGGAAGGCGCCGGCAGCAGTGGTCAGGACCTGATGGCAAGCGGTAACACCACGGTTA300 AGGCGACCTTCGGTAAGGACTCCAGTGTTGTTAAATGGGTTGTTCTGGCTGAAGTTCTGG360 TCGGTGCTGTCATGTACATGATGACCAAAAACG TCAAGTTCCTGGCCGGTTTTGCCATCA420 TCTCTGTATTTATTGCTGTGGTTATGGCCGTCGTTGGCCTCTGATAATCTAGAGTCGACC480 TGCAGGCATGCAAGCTTGGCACTGGCCGTCGTTTTACAACGTCGTGACTGGGAAAACCCT540 (2) INFORMATION FOR SEQ ID NO:18: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 137 amino acids (B) TYPE: amino acid (C) STRANDEDNESS: unknown (D) TOPOLOGY: unknown (xi) SEQUENCE DESCRIPTION: SEQ ID NO:18: MetAsnAlaValLeuSerValGlnGlyAlaSerAlaProValLysLys 1 51015 LysSerPhePheSerLysPheThrArgLeuAsnMetLeuArgLeuAla 202530 ArgAlaVal IleProAlaAlaValLeuMetMetPhePheProGlnLeu 354045 AlaMetAlaAlaGlySerAlaAlaAlaGluGluGluGluTyrMetPro 50 5560 MetGluGlyAlaGlySerSerGlyGlnAspLeuMetAlaSerGlyAsn 65707580 ThrThrValLy sAlaThrPheGlyLysAspSerSerValValLysTrp 859095 ValValLeuAlaGluValLeuValGlyAlaValMetTyrMetMetThr 100105110 LysAsnValLysPheLeuAlaGlyPheAlaIleIleSerValPheIle 115120125 AlaValVa lMetAlaValValGlyLeu 130135 (2) INFORMATION FOR SEQ ID NO:19: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 67 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: unknown (D) TOPOLOGY: unknown (xi) SEQUENCE DESCRIPTION: SEQ ID NO:19: GGGGGGAGCTCTCTGC AAAGAGACAGTCATAATGAAATACCTATTGCCTACGGCAGCCGC60 TGGATTG67 (2) INFORMATION FOR SEQ ID NO:20: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 66 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: unknown (D) TOPOLOGY: unknown (xi) SEQUENCE DESCRIPTION: SEQ ID NO:20: GGGGGGCCGCGGCCGCGGCCATGGCCGGCTGGGCCGCGAGTAATAACAATCCAGCGGCTG60 CCGTAG 66 (2) INFORMATION FOR SEQ ID NO:21: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 84 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: unknown (D) TOPOLOGY: unknown (xi) SEQUENCE DESCRIPTION: SEQ ID NO:21: GGGGGGCCGCGGCCGCGGAGGAAGAAGAGTACAACCCGAACGAAGGCGCCGCCTAGACTG60 TTGAAAGTTGTTTAGCAAAACCTC84 (2) INFORMATION FOR SEQ ID NO:22: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 44 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: unknown (D) TOPOLOGY: unknown (xi) SEQUENCE DESCRIPTION: SEQ ID NO:22: GGGC CGAATTCCTATTAAGACTCCTTATTACGCAGTATGTTAGC44 (2) INFORMATION FOR SEQ ID NO:23: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 53 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: unknown (D) TOPOLOGY: unknown (xi) SEQUENCE DESCRIPTION: SEQ ID NO:23: GGGGGGACT AGTGCGGCCGCGGGCGCCGCTGAAACTGTTGAAAGTTGTTTAGC53 (2) INFORMATION FOR SEQ ID NO:24: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 35 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: unknown (D) TOPOLOGY: unknown (xi) SEQUENCE DESCRIPTION: SEQ ID NO:24: GGGGGGGGATCCA GAGGGTTGATATAAGTATAGCC35 (2) INFORMATION FOR SEQ ID NO:25: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 110 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (ii) MOLECULE TYPE: cDNA (iii) HYPOTHETICAL: NO (iv ) ANTI-SENSE: NO (v) FRAGMENT TYPE: (vi) ORIGINAL SOURCE: (xi) SEQUENCE DESCRIPTION: SEQ ID NO:25: AGCTGGAGCTCTCTGCCAAGGAGACAGTCATAATGAAATACCTATTGCCTACGGCAGCCC60 CTGGATTGTTATTACTCGCGGCCCAGCCCGGCCATGGCCGCGGCCGCTCT110 (2) INFORMATION FOR SEQ ID NO:26: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 110 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (ii) MOLECULE TYPE: cDNA (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: NO (v) FRAGMENT TYPE: (vi) ORIGINAL SOURCE: (xi) SEQUENCE DESCRIPTION: SEQ ID NO:26: AGAGCG GCCCCGGCCATGCCCGGCTGGGCCGCGAGTAATAACAATCCAGCGGCTGCCGTA60 GGCAATAGGTATTTCATTATGACTGTCTCCTTGGCAAGAGAGCTCCAGCT110
Claims (14)
Priority Applications (6)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US08/258,026 US5516637A (en) | 1994-06-10 | 1994-06-10 | Method involving display of protein binding pairs on the surface of bacterial pili and bacteriophage |
CA002169358A CA2169358A1 (en) | 1994-06-10 | 1995-06-12 | A method for displaying proteins |
JP8502436A JPH09504181A (en) | 1994-06-10 | 1995-06-12 | How to display protein |
EP95923861A EP0722495A1 (en) | 1994-06-10 | 1995-06-12 | A method for displaying proteins |
PCT/US1995/007541 WO1995034648A1 (en) | 1994-06-10 | 1995-06-12 | A method for displaying proteins |
AU28282/95A AU697865B2 (en) | 1994-06-10 | 1995-06-12 | A method for displaying proteins |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US08/258,026 US5516637A (en) | 1994-06-10 | 1994-06-10 | Method involving display of protein binding pairs on the surface of bacterial pili and bacteriophage |
Publications (1)
Publication Number | Publication Date |
---|---|
US5516637A true US5516637A (en) | 1996-05-14 |
Family
ID=22978788
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
US08/258,026 Expired - Fee Related US5516637A (en) | 1994-06-10 | 1994-06-10 | Method involving display of protein binding pairs on the surface of bacterial pili and bacteriophage |
Country Status (6)
Country | Link |
---|---|
US (1) | US5516637A (en) |
EP (1) | EP0722495A1 (en) |
JP (1) | JPH09504181A (en) |
AU (1) | AU697865B2 (en) |
CA (1) | CA2169358A1 (en) |
WO (1) | WO1995034648A1 (en) |
Cited By (561)
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WO1998020159A1 (en) * | 1996-11-07 | 1998-05-14 | Ramot University Authority For Applied Research & Industrial Development Ltd. | Representations of bimolecular interactions |
US5922537A (en) * | 1996-11-08 | 1999-07-13 | N.o slashed.AB Immunoassay, Inc. | Nanoparticles biosensor |
WO1999047538A1 (en) | 1998-03-19 | 1999-09-23 | Human Genome Sciences, Inc. | Cytokine receptor common gamma chain like |
US5981249A (en) * | 1998-02-05 | 1999-11-09 | Spectral Diagnostics, Inc. | Single-chain polypeptides comprising creatine kinase M and creatine kinase B |
US6040136A (en) * | 1990-12-03 | 2000-03-21 | Genentech, Inc. | Enrichment method for variant proteins with altered binding properties |
WO2002002641A1 (en) | 2000-06-16 | 2002-01-10 | Human Genome Sciences, Inc. | Antibodies that immunospecifically bind to blys |
WO2002064612A2 (en) | 2001-02-09 | 2002-08-22 | Human Genome Sciences, Inc. | Human g-protein chemokine receptor (ccr5) hdgnr10 |
US20020150534A1 (en) * | 1994-11-07 | 2002-10-17 | Guo-Liang Yu | Tumor necrosis factor-gamma |
US6475785B1 (en) | 1997-12-18 | 2002-11-05 | Spectral Diagnostics, Inc. | Single-chain polypeptides comprising troponin I N-terminal fragments and troponin C |
US6479280B1 (en) * | 1999-09-24 | 2002-11-12 | Vlaams Interuniversitair Institutuut Voor Biotechnologie Vzw | Recombinant phages capable of entering host cells via specific interaction with an artificial receptor |
US20030039958A1 (en) * | 1999-12-03 | 2003-02-27 | Domantis Limited | Direct screening method |
US20030044863A1 (en) * | 2001-07-20 | 2003-03-06 | Children's Medical Center Corporation | Invasion complex and methods of targeting |
US20030068320A1 (en) * | 2001-03-02 | 2003-04-10 | Christine Dingivan | Methods of administering/dosing CD2 antagonists for the prevention and treatment of autoimmune disorders or inflammatory disorders |
US20030091593A1 (en) * | 2001-09-14 | 2003-05-15 | Cytos Biotechnology Ag | In vivo activation of antigen presenting cells for enhancement of immune responses induced by virus like particles |
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US20060239533A1 (en) * | 2001-06-04 | 2006-10-26 | Triantafyllos Tafas | Method for detecting infectious agents using computer controlled automated image analysis |
US20060269556A1 (en) * | 2005-04-18 | 2006-11-30 | Karl Nocka | Mast cell activation using siglec 6 antibodies |
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WO1995034648A1 (en) | 1995-12-21 |
AU697865B2 (en) | 1998-10-22 |
AU2828295A (en) | 1996-01-05 |
CA2169358A1 (en) | 1995-12-21 |
EP0722495A1 (en) | 1996-07-24 |
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