US5640764A - Method of forming a tubular feed-through hermetic seal for an implantable medical device - Google Patents
Method of forming a tubular feed-through hermetic seal for an implantable medical device Download PDFInfo
- Publication number
- US5640764A US5640764A US08/446,138 US44613895A US5640764A US 5640764 A US5640764 A US 5640764A US 44613895 A US44613895 A US 44613895A US 5640764 A US5640764 A US 5640764A
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- United States
- Prior art keywords
- tube
- capsule
- casing
- sealing
- hermetically sealing
- Prior art date
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- Expired - Lifetime
Links
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- 239000002775 capsule Substances 0.000 claims abstract description 55
- 238000007789 sealing Methods 0.000 claims abstract description 36
- 239000007789 gas Substances 0.000 claims abstract description 26
- 239000004020 conductor Substances 0.000 claims abstract description 9
- 238000013022 venting Methods 0.000 claims abstract description 3
- 239000011521 glass Substances 0.000 claims description 40
- 239000011324 bead Substances 0.000 claims description 23
- 229910052751 metal Inorganic materials 0.000 claims description 13
- 239000002184 metal Substances 0.000 claims description 13
- 239000011261 inert gas Substances 0.000 claims description 10
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- 229910052734 helium Inorganic materials 0.000 description 5
- SWQJXJOGLNCZEY-UHFFFAOYSA-N helium atom Chemical compound [He] SWQJXJOGLNCZEY-UHFFFAOYSA-N 0.000 description 5
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- 238000007792 addition Methods 0.000 description 1
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Images
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01M—TESTING STATIC OR DYNAMIC BALANCE OF MACHINES OR STRUCTURES; TESTING OF STRUCTURES OR APPARATUS, NOT OTHERWISE PROVIDED FOR
- G01M3/00—Investigating fluid-tightness of structures
- G01M3/02—Investigating fluid-tightness of structures by using fluid or vacuum
- G01M3/04—Investigating fluid-tightness of structures by using fluid or vacuum by detecting the presence of fluid at the leakage point
- G01M3/20—Investigating fluid-tightness of structures by using fluid or vacuum by detecting the presence of fluid at the leakage point using special tracer materials, e.g. dye, fluorescent material, radioactive material
- G01M3/22—Investigating fluid-tightness of structures by using fluid or vacuum by detecting the presence of fluid at the leakage point using special tracer materials, e.g. dye, fluorescent material, radioactive material for pipes, cables or tubes; for pipe joints or seals; for valves; for welds; for containers, e.g. radiators
- G01M3/226—Investigating fluid-tightness of structures by using fluid or vacuum by detecting the presence of fluid at the leakage point using special tracer materials, e.g. dye, fluorescent material, radioactive material for pipes, cables or tubes; for pipe joints or seals; for valves; for welds; for containers, e.g. radiators for containers, e.g. radiators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N1/00—Electrotherapy; Circuits therefor
- A61N1/18—Applying electric currents by contact electrodes
- A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
- A61N1/36—Applying electric currents by contact electrodes alternating or intermittent currents for stimulation
- A61N1/372—Arrangements in connection with the implantation of stimulators
- A61N1/375—Constructional arrangements, e.g. casings
- A61N1/3752—Details of casing-lead connections
- A61N1/3754—Feedthroughs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N1/00—Electrotherapy; Circuits therefor
- A61N1/18—Applying electric currents by contact electrodes
- A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
- A61N1/36—Applying electric currents by contact electrodes alternating or intermittent currents for stimulation
- A61N1/372—Arrangements in connection with the implantation of stimulators
- A61N1/37205—Microstimulators, e.g. implantable through a cannula
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
- Y10T29/00—Metal working
- Y10T29/49—Method of mechanical manufacture
- Y10T29/49002—Electrical device making
- Y10T29/49117—Conductor or circuit manufacturing
- Y10T29/49169—Assembling electrical component directly to terminal or elongated conductor
- Y10T29/49171—Assembling electrical component directly to terminal or elongated conductor with encapsulating
- Y10T29/49172—Assembling electrical component directly to terminal or elongated conductor with encapsulating by molding of insulating material
Definitions
- the present invention relates to hermetically sealed cases or housings suitable for implantation within living tissue, and more particularly, to a method and apparatus for hermetically sealing an implantable device which prevents moisture from forming within the sealed device.
- the method and apparatus utilize a tubular feedthrough to vent moisture and other volatile gases trapped within the sealed device during the manufacturing process. Such tubular feedthrough also facilitates hermeticity testing of the implantable device during the manufacturing process.
- Hermetically sealed cases or housings are widely used to protect electronic or other components that may be susceptible to damage or malfunction from exposure to the surrounding environment.
- the hermetic seal is simply an airtight, durable seal that is long-lasting and physically rugged.
- the interior of an hermetically sealed enclosure is filled with an inert gas such as helium, to further retard the deterioration of the component or components inside.
- the tightness of the hermetic seal referred to as the hermeticity
- the hermeticity is typically measured or specified in terms of the leakage rate through the seal, expressed in cc/sec of helium at standard temperature and pressure.
- the hermeticity can only be measured by placing a radioactive gas within the enclosure and then using an appropriate radiation detector to "sniff" the seal for radioactive leaks.
- the hermetically sealed case (which must be made from a material that is compatible with body tissue, such as titanium, platinum or stainless steel or glass) serves a dual purpose: (1) it protects the electrical or other components housed in the device from body fluids and tissue, which fluids and tissue could otherwise prevent the components from performing their desired function; and (2) it protects the body tissue and fluids from the electrical or other components, which components may be made at least in part from materials that may be damaging to body tissue, and which therefore could pose a potential health risk to the patient wherein they are implanted. It is thus critically important that the hermetic seal of an implanted device be especially long-lasting and physically rugged. For this reason, stringent requirements are imposed on the hermeticity of an implanted device, typically requiring a seal that provides a helium leakage rate of less than 10 -8 cc/sec at standard temperature and pressure (STP).
- STP standard temperature and pressure
- hermetic conductive feedthroughs in order to establish electrical contact between the appropriate circuitry sealed in the hermetically closed case or capsule and an external electrode that must be in contact with the body tissue or fluids outside of the sealed case or capsule.
- a pacemaker for example, it is common to provide such a feedthrough by using a feedthrough capacitor.
- a representative feedthrough capacitor is described in U.S. Pat. No. 4,152,540.
- a hermetic feedthrough is typically used to establish electrical connections between the appropriate electronic components or circuitry sealed in the hermetically closed case or capsule and an external control device, or monitoring equipment.
- an hermetic feedthrough for implantable devices has consisted of a ceramic or glass bead that is bonded chemically at its perimeter through brazing or the use of oxides, and/or mechanically bonded through compression, to the walls of the sealed case or capsule.
- a suitable wire or other conductor passes through the center of the bead, which wire or conductor must also be sealed to the bead through chemical bonds and/or mechanical compression.
- the feedthrough is thus circular, and the wire(s) or conductor(s) mounted within the bead are centered or mounted in a uniform pattern centrally positioned within the bead. Such centering is necessary due to the thermal coefficients required for the different expansion rates that occur when heat is applied to either create a compression seal or to create an oxide or bronze bond.
- glass beads are fused within the device cases or capsules to hermetically seal the case or capsule.
- Water vapors are often produced by the gas flame fusing and are often trapped inside the capsules which water vapors may lead to eventual failure of the implanted device.
- Another problem associate with conventional sealing processes is related to the expansion of gases remaining inside the sealed capsule. As the glass bead is fused to the case or capsule, air inside the case or capsule expands. The expanding air tries to escape from the case or capsule and is likely to result in localized stress in the glass fusion areas and may even form a hole through the molten glass. If a hole forms within the glass, it is very difficult if not impossible to repair.
- Still other art relating generally to methods for forming hermetically sealed cases having electrical feedthroughs and vias include U.S. Pat. No. 4,525,766 issued to Petersen, U.S. Pat. No. 4,861,641 issued to Foster et al., and U.S. Pat. No. 4,882,298 issued to Moeller et al. While these patents teach improvements in the art, such teachings are limited to use with semiconductor substrates and are not easily adaptable for use with microminiature devices implantable within living tissue.
- the present invention addresses the above and other needs by providing a low cost method of encapsulating microstimulators and other implantable devices through the use of a tubular feedthrough.
- the tubular feedthrough allows moisture and expanding air trapped within the sealed device to vent during the manufacturing process.
- the tubular feedthrough facilitates hermeticity testing at all stages of manufacturing by providing a channel through which a leakage testing apparatus may be attached to detect the presence of inert gases that are introduced in the environment surrounding the encapsulated device and that leak thereinto.
- an inert gas may be introduced into the capsule (encapsulated device) under pressure using the tubular feedthrough and thereafter the environment surrounding the capsule may be tested to see if any of the inert gas has leaked out from the capsule.
- Such leakage detection of the capsule can advantageously be accomplished via the tubular feedthrough at any time prior to sealing the feedthrough, or thereafter (in the case of inert gases being introduced into the capsule).
- the present invention also permits electrical connection between electronic circuits sealed within the case or capsule and electrodes and/or other electrical terminals on the outside of the case or capsule. That is, while preventing moisture and expanding air from becoming trapped within the capsule as the assembly is sealed, as explained above, the tubular feedthrough may further provide a conductive path through the seal through which signal connections can be made.
- Alternative embodiments of the conductive tubular feedthrough contemplate more than just electrical conduction, but also include optical conduction, fluid conduction, etc., to allow signal connections between the interior and exterior of the hermetically sealed case or capsule.
- FIG. 1 is a side, cross sectional view of a simple implantable device that is hermetically sealed in accordance with the present invention.
- FIG. 2 is a side, cross sectional view of a microstimulator having the tubular feedthrough hermetic seal of the present invention.
- FIG. 3 is a flow diagram illustrating the method of the invention.
- the tubular feedthrough disclosed herein is adapted for use with many different implantable electronic devices and particularly where it is advantageous to prevent entrapment of water vapors and other volatile gases within the sealed device.
- the disclosed method and apparatus is also adapted for use with hermetically sealed devices to allow hermeticity testing throughout the manufacturing process.
- the preferred embodiment of the tubular feedthrough is particularly adapted for use with microstimulators, microtransducers, microtelemeters or similar electronic devices, or combinations of such devices.
- the invention may be used with the microstimulator of the type disclosed in U.S. Pat. Nos. 5,193,539; and 5,193,540, incorporated herein by reference.
- microstimulators typically comprises: a capsule which is generally tubular glass capillary having two open ends; an electronic assembly; one or more hermetic seals and feedthroughs; and one or more active electrodes. It is to be understood, however, that the invention can be practiced with any type of implantable device wherein a hermetic seal is required, regardless of whether such device requires electronic circuitry or not.
- the implantable device 13 includes a hermetically sealed casing 20, and a tube 30 that has one end 34 disposed within the casing 20 and the other end 35 extending out from the casing 20.
- the tube 30 is hermetically sealed to the casing 20 with the aid of a suitable seal 29 at the point of entry into the casing 20.
- an assembly 40 such as an electronic assembly, optical assembly or other component or element may be disposed within the casing 20 and connected to the tube 30 such that an appropriate connection between the encased assembly 40 and the outside of the casing 30 is established.
- a seal 49 is disposed in the end 35 of the tube 30 after any volatile gases within the casing 20 have been vented through the tube and after the implanted device 13 has been vacuum baked to drive out any moisture from the casing 20 through the tube 30.
- Such seal 49 may comprise a simple plug, or simply a crimp in the tube 30, or a weld, or any other means for hermetically closing the end 35 of the tube 30.
- hermeticity testing of the casing 20 can be easily accomplished in one of several manners. For example, by connecting a leakage detector 33 to the end 35 of the tube 30 extending from the casing 20 and introducing an inert detectable gas in the environment outside the sealed casing 20, one may find defective seals in the casing 20 by detecting the presence of the inert gas that leaks from the outside environment into the sealed casing 20. Alternatively, leaks may be detected by introducing an inert detectable gas into to the casing 20 via the tube 30 and subsequently detecting the presence of any inert detectable gas using the leakage detector 33 that leaks out of the casing 20.
- the microstimulator 12 includes a first hermetic feedthrough conductor 14 that is formed at the aft end 16 of the glass capillary 20.
- the first feedthrough conductor 14 is preferably a metal wire 22 extending through a preformed glass bead 24.
- the preformed glass bead 24 is then placed within the aft end 16 of the glass capillary 20 and is hermetically sealed therein by fusing the aft end 16 of the glass capillary 20 with the glass bead 24 using a gas flame.
- a second feedthrough conductor 26 is formed by sealing a second glass bead 28 around a metal tubing 30.
- This second glass bead 28 is also dimensioned to snugly fit into the open forward end 32 of the glass capillary 20.
- the aft end 34 of the metal tubing 30 is then connected to the microstimulator electronic assembly 40 proximate the forward end 36 thereof.
- the microstimulator electronic assembly 40 is then slid into the glass capillary 20.
- the radial dimension of the glass capillary 20 is such that the microstimulator electronic assembly 40 can be slid therein leaving a small clearance therebetween.
- the longitudinal dimensions of the microstimulator electronic assembly 40 and the glass capillary 20 are such that when the aft end 38 of the microstimulator electronic assembly 40 reaches the first conductive feedthrough 14, the open forward end 32 of the glass capillary 20 aligns with the second glass bead 28.
- a conductive epoxy connection 44 is made between the aft end 38 of the microstimulator electronic assembly 40 and the first hermetic feedthrough conductor 14.
- Hermetic sealing of the forward end 32 of the glass capillary 20 is accomplished by fusing the forward end 32 of the glass capillary 20 with the second glass bead 28 using a gas flame.
- the metal tube 30 extending from the microstimulator electronic assembly 40 through the second glass bead 28 allows the expanded air and moisture to escape during the fusing process.
- the entire microstimulator 12 is vacuum baked until all the moisture and other volatile contaminates are driven out of the microstimulator capsule.
- an inert gas such as helium or argon, may be pumped into the capsule.
- the forward end 46 of the metal tube 30 is then sealed or pinched off with a very small flame or some other sealing method such as a tungsten inert gas (TIG) flame, resistance welding, or laser welding.
- TIG tungsten inert gas
- a microstimulator electrode wire 50 can be attached to the metal tube 30, as needed, during the pinching process or in a subsequently performed attachment step.
- the method of forming a tubular feedthrough for an implanted electronic device in accordance with the present invention comprises three essential steps including: (a) attaching one end of a metal tube to an electronic assembly such that an electrical connection or feedthrough is established; (b) encasing the electronic assembly within a capsule such that one end of the metal tube resides in the interior of the sealed capsule while the other end extends out from of the capsule; and (c) hermetically sealing the metal tube to the capsule.
- the steps are performed in such a manner that the tubular feedthrough vents any moisture and other volatile gases that are trapped within the capsule and further allows hermeticity testing or leak detection of the sealed capsule. Changes in the order of the aforementioned steps may be made without sacrificing the advantages presented by this method.
- the method essentially comprises four steps.
- the first step involves forming a venting feedthrough by having a glass bead hermetically sealed around a platinum-iridium tube.
- the platinum-iridium tube is preferably a small diameter tube on the order of about 0.25 mm outside diameter by 0.125 mm inside diameter by about 2.5 mm in length.
- One end of the platinum iridium tubing is attached to the forward end of the microstimulator electronic assembly forming an electrical connection therewith.
- the second step involves fusing the glass bead to a suitable glass capsule such that the microstimulator electronic assembly is fully encased within the capsule (block 62 of FIG. 3).
- the glass bead and glass capsule are preferably dimensioned such that the glass bead snugly fits into the an open end of the glass capsule leaving little or no clearance therebetween.
- the glass-to-glass fusing is preferably/done using a gas-oxygen flame (or, as indicated below, an infrared laser) and is performed at a temperature of about 1180°-1200° C. (e.g., 1189° C.) being careful not to sustain heat damage to the microstimulator electronic assembly.
- the platinum-iridium tube extending from the microstimulator electronic assembly through the glass bead provides a path through which the expanded air and moisture are vented.
- an infrared laser could be used to seal the end of the tube.
- An infrared laser is particularly well suited for this operation because it may be used to melt the glass in an inert atmosphere, such as argon gas, and as a result no water is generated as the melting operation is performed.
- the infrared laser when used in an inert atmosphere, prevents the formation of water.
- the third step in the described method for hermetically sealing microstimulators is vacuum baking of the entire microstimulator in an evacuated oven until all the moisture and other unwanted gases are driven out of the microstimulator capsule (block 64 of FIG. 3).
- the vacuum baking step is preferably performed at a temperature of about 80° C., for approximately 72 hours, again being careful not to damage the microstimulator electronic assembly.
- the microstimulator is cooled (block 66), and then the microstimulator electrode wires, or other wires needed for operation of the device, may then be inserted into the open end of the platinum-iridium tubing (block 68 of FIG. 3).
- the microstimulator electrode wires are also made from platinum-iridium and are dimension to fit within the platinum-iridium tube.
- the platinum-iridium electrode wire and platinum-iridium tube are then hermetically sealed (block 70 of FIG. 3) with a process such as resistance welding, a TIG flame, or laser welding. It should also be noted that the tube itself may be sealed without inserting an electrode wire therein, and the tube then functions (when properly electrically connected to the appropriate circuitry within the microstimulator) as the electrode wire. It is further noted that other dissimilar metals, which do not corrode, and which have an appropriate corresponding coefficient of expansion, may be used in lieu of platinum-iridium as the tube material.
- inert detectable gases such as helium
- inert detectable gases such as helium
- This additional step facilitates hermeticity testing at all subsequent stages of manufacturing. By detecting the presence of these inert gases outside the sealed capsule using various leakage tests, defective devices can be identified and receive the appropriate disposition.
- the present invention thus provides an improved method and apparatus for hermetically sealing microstimulators and other implantable electronic devices that prevents moisture and expanding air from becoming trapped within the sealed device.
- various changes and additions may be made in the described methods and in the form, construction and arrangement of the elements thereof without departing from the spirit and scope of the invention or sacrificing all of its material advantages, the forms and methods hereinbefore described being merely exemplary embodiments thereof. Therefore, it is not intended that the scope of the invention be limited to the specific embodiments and processes described. Rather, it is intended that the scope of this invention be determined by the appending claims and their equivalents.
Abstract
Description
Claims (13)
Priority Applications (2)
Application Number | Priority Date | Filing Date | Title |
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US08/446,138 US5640764A (en) | 1995-05-22 | 1995-05-22 | Method of forming a tubular feed-through hermetic seal for an implantable medical device |
US08/829,137 US5843140A (en) | 1995-05-22 | 1997-03-28 | Tubular feedthrough system for hermetically sealed devices |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
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US08/446,138 US5640764A (en) | 1995-05-22 | 1995-05-22 | Method of forming a tubular feed-through hermetic seal for an implantable medical device |
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US08/829,137 Division US5843140A (en) | 1995-05-22 | 1997-03-28 | Tubular feedthrough system for hermetically sealed devices |
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US5640764A true US5640764A (en) | 1997-06-24 |
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US08/446,138 Expired - Lifetime US5640764A (en) | 1995-05-22 | 1995-05-22 | Method of forming a tubular feed-through hermetic seal for an implantable medical device |
US08/829,137 Expired - Lifetime US5843140A (en) | 1995-05-22 | 1997-03-28 | Tubular feedthrough system for hermetically sealed devices |
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US08/829,137 Expired - Lifetime US5843140A (en) | 1995-05-22 | 1997-03-28 | Tubular feedthrough system for hermetically sealed devices |
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US6051169A (en) * | 1997-08-27 | 2000-04-18 | International Business Machines Corporation | Vacuum baking process |
US20040058186A1 (en) * | 2002-06-28 | 2004-03-25 | Jay Daulton | Self-centering braze assembly |
US20040193229A1 (en) * | 2002-05-17 | 2004-09-30 | Medtronic, Inc. | Gastric electrical stimulation for treatment of gastro-esophageal reflux disease |
US20040236382A1 (en) * | 2003-05-19 | 2004-11-25 | Medtronic, Inc. | Gastro-electric stimulation for increasing the acidity of gastric secretions or increasing the amounts thereof |
US20040236381A1 (en) * | 2003-05-19 | 2004-11-25 | Medtronic, Inc. | Gastro-electric stimulation for reducing the acidity of gastric secretions or reducing the amounts thereof |
US20050075702A1 (en) * | 2003-10-01 | 2005-04-07 | Medtronic, Inc. | Device and method for inhibiting release of pro-inflammatory mediator |
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US20060183979A1 (en) * | 2002-01-29 | 2006-08-17 | Rini Christopher J | Methods for using an implantable sensor unit |
US20060283624A1 (en) * | 2001-03-30 | 2006-12-21 | Jerry Ok | Method and apparatus for providing hermetic electrical feedthrough |
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US7498516B1 (en) | 2006-06-14 | 2009-03-03 | Boston Scientific Neuromodulation Corporation | Feedthru assembly |
US20090276005A1 (en) * | 2008-05-01 | 2009-11-05 | Benjamin David Pless | Method and Device for the Treatment of Headache |
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US20100274313A1 (en) * | 2009-04-22 | 2010-10-28 | Carl Lance Boling | Implantable Neurostimulator with Integral Hermetic Electronic Enclosure, Circuit Substrate, Monolithic Feed-Through, Lead Assembly and Anchoring Mechanism |
US20100305664A1 (en) * | 2009-06-01 | 2010-12-02 | Wingeier Brett M | Methods and Devices for Adrenal Stimulation |
US7860544B2 (en) | 1998-04-30 | 2010-12-28 | Abbott Diabetes Care Inc. | Analyte monitoring device and methods of use |
US7920907B2 (en) | 2006-06-07 | 2011-04-05 | Abbott Diabetes Care Inc. | Analyte monitoring system and method |
US7928850B2 (en) | 2007-05-08 | 2011-04-19 | Abbott Diabetes Care Inc. | Analyte monitoring system and methods |
US7976778B2 (en) | 2001-04-02 | 2011-07-12 | Abbott Diabetes Care Inc. | Blood glucose tracking apparatus |
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