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Brevets

A dosage form and a method are disclosed and claimed for administering a drug in a sustained and constantly ascending rate per unit time to provide an intended therapeutic effect while concomitantly lessening the development of unwanted effects.

InventeursSuneel K. Gupta, Diane R. Guinta, Carol A. Christopher, Samuel R. Saks
Cessionnaire d'origineALZA Corporation
Classification américaine actuelle514/317; 514/376; 514/654; 514/964
Classification internationale: A61K 3142; A61K 31135; A61K 31445

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Citations

Brevet cité Date de dépôt Date de délivrance Cessionnaire d'origine Titre
US25076319 mars 194516 mai 1950PYRIDINE AND PIPERDJINE COMPOUNDS
US264860921 janv. 194911 août 1953COMPRESSED
US26681622 févr. 1954PREPARATION
US267694518 oct. 195027 avr. 1954CONDENSATION POLYMERS OF HYDROXY
US273830318 juil. 195213 mars 1956 BLYTHE
US295788022 janv. 195825 oct. 1960PROCESS FOR THE CONVERSION OF
US299643116 déc. 195315 août 1961CERTIFICATION OF CORRECTION
US313938326 juin 19611964METHOD FOR ENCAPSULATING THE SAME
US362521418 mai 19707 déc. 1971DRUG-DELIVERY DEVICE
US37739198 oct. 197020 nov. 1973POLYLACTIDE-DRUG MIXTURES
US381144427 déc. 197215 sept. 1974BIOERODIBLE OCULAR DEVICE
US396241425 oct. 19748 juin 1976Alza CorporationStructured bioerodible drug delivery device
US399251829 sept. 197516 nov. 1976G. D. Searle & Co.Method for making a microsealed delivery device
US40667478 avr. 19763 janv. 1978Alza CorporationPolymeric orthoesters housing beneficial drug for controlled release therefrom
US407034716 août 197624 janv. 1978Alza CorporationPoly(orthoester) co- and homopolymers and poly(orthocarbonate) co- and homopolymers having carbonyloxy functionality
US40790385 mars 197614 mars 1978Alza CorporationPoly(carbonates)
US40839498 juil. 197411 avr. 1978Byk Gulden Lomberg Chemische Fabrik GmbHNew oral form of medicament and a method for producing it
US409370928 janv. 19756 juin 1978Alza CorporationDrug delivery devices manufactured from poly(orthoesters) and poly(orthocarbonates)
US443415322 mars 198228 févr. 1984Alza CorporationDrug delivery system comprising a reservoir containing a plurality of tiny pills
US472161317 sept. 198426 janv. 1988ALZA CorporationDelivery system comprising means for shielding a multiplicity of reservoirs in selected environment of use
US475247024 nov. 198621 juin 1988Controlled release indomethacin
US485322926 oct. 19871 août 1989ALZA CorporationMethod for adminstering tiny pills

Revendications

1. A method for lessening the incidence of tolerance to methylphenidate administered to an Attention-Deficit Disorder patient who develops tolerance to methylphenidate, wherein the method comprises administering orally to the patient a dosage form tablet that delivers 100 ng to 500 mg of methylphenidate in a sustained and increasing dose over 16 hours to produce the intended effect.

2. A method for lessening the incidence of tolerance in a patient having Attention-Deficit Disorder, wherein the method comprises administering a pharmaceutically acceptable composition comprising 100 ng to 500 mg of methylphenidate and a pharmaceutically acceptable carrier, that is administered in a sustained and increasing dose for lessening the incidence of tolerance in this patient.

3. A method for treating Attention-Deficit Disorder in a patient, wherein the method comprises administering a pharmaceutically acceptable composition comprising 100 ng to 500 mg of a member selected from the group consisting of amphetamine, dextroamphetamine, methamphetamine, phenylisopropylamine, and pemoline, and a pharmaceutically acceptable carrier, in a sustained and increasing dose for treating Attention-Deficit Disorder in the patient.

4. A method for maintaining the therapeutic effect of methylphenidate in an Attention-Deficit Disorder patient who acquires tolerance to methylphenidate, wherein the method comprises administering orally to the patient a dosage form tablet comprising 100 ng to 500 mg of methylphenidate that delivers the methylphenidate in a controlled and increasing dose over 16 hours to maintain the therapeutic effect in the patient.

5. A method for compensating for a decrease in the therapeutic effect to methylphenidate in an Attention-Deficit Disorder patient, wherein the method comprises administering a dosage form tablet comprising 100 ng to 500 mg of methylphenidate to the patient that administers the methylphenidate in a continually-ascending rate over 16 hours to compensate for the decrease in the therapeutic effect.

6. A method for treating Attention-Deficit Disorder in a human, wherein the method comprises administering orally to a human having Attention-Deficit Disorder a dosage form that administers a sustained and continuously ascending dose of 100 ng to 500 mg.

7. A method of treating Attention-Deficit Disorder in a human wherein the method comprises administering orally to a human having Attention-Deficit Disorder a dosage form that administers a sustained and continuously ascending dose of 5 mg to 75 mg over 12 hours of a drug selected from the group consisting of methylphenidate and its pharmaceutically acceptable salts for treating Attention-Deficit Disorders in the human.

8. A method of treating Attention-Deficit Disorder in a human wherein the method comprises administering orally to a human having Attention-Deficit Disorder a dosage form that administers a sustained and continuously ascending dose of 100 ng to 500 mg over 16 hours of a drug selected from the group consisting of amphetamine, dextroamphetamine, methamphetamine, threomethylphenidate, phenylisopropylamine and pemoline for treating Attention-Deficit Disorders in the human.

9. A method for the management of Attention-Deficit Disorder and Attention-Deficit Hyperactivity Disorder in a patient, wherein the method comprises administering orally to the patient a dosage form comprising 100 ng to 500 mg of methylphenidate that is administered in a sustained and continuosly ascending dose throughout the school day for the management of Attention-Deficit Disorder and Attention-Deficit Hyperactivity Disorder in the patient.

10. A dosage form tablet for treating Attention-Deficit Disorder comprising 100 ng to 500 mg of methylphenidate in admixture with a pharmaceutically acceptable carrier that releases the methylphenidate in a sustained and increasing dose for treating Attention-Deficit Disorder.

11. A dosage form tablet for treating Attention-Deficit Hyperactivity Disorder, comprising 100 ng to 500 mg of a member selected from the group consisting of methylphenidate and its pharmaceutically acceptable salts mixed with a pharmaceutically acceptable carrier that is delivered in a controlled and increasing dose for treating Attention-Deficit Hyperactivity Disorder.