US6093201A - Biocompatible absorbable polymer plating system for tissue fixation - Google Patents

Biocompatible absorbable polymer plating system for tissue fixation Download PDF

Info

Publication number
US6093201A
US6093201A US09/233,569 US23356999A US6093201A US 6093201 A US6093201 A US 6093201A US 23356999 A US23356999 A US 23356999A US 6093201 A US6093201 A US 6093201A
Authority
US
United States
Prior art keywords
plate
biocompatible
biocompatible plate
group
poly
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
US09/233,569
Inventor
Kevin L. Cooper
David W. Overaker
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Ethicon Inc
Original Assignee
Ethicon Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ethicon Inc filed Critical Ethicon Inc
Priority to US09/233,569 priority Critical patent/US6093201A/en
Assigned to ETHICON, INC. reassignment ETHICON, INC. ASSIGNMENT OF ASSIGNORS INTEREST (SEE DOCUMENT FOR DETAILS). Assignors: COOPER, KEVIN L., OVERAKER, DAVID W.
Application granted granted Critical
Publication of US6093201A publication Critical patent/US6093201A/en
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Images

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00Surgical instruments, devices or methods, e.g. tourniquets
    • A61B17/56Surgical instruments or methods for treatment of bones or joints; Devices specially adapted therefor
    • A61B17/58Surgical instruments or methods for treatment of bones or joints; Devices specially adapted therefor for osteosynthesis, e.g. bone plates, screws, setting implements or the like
    • A61B17/68Internal fixation devices, including fasteners and spinal fixators, even if a part thereof projects from the skin
    • A61B17/80Cortical plates, i.e. bone plates; Instruments for holding or positioning cortical plates, or for compressing bones attached to cortical plates
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00Surgical instruments, devices or methods, e.g. tourniquets
    • A61B17/04Surgical instruments, devices or methods, e.g. tourniquets for suturing wounds; Holders or packages for needles or suture materials
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00Surgical instruments, devices or methods, e.g. tourniquets
    • A61B17/56Surgical instruments or methods for treatment of bones or joints; Devices specially adapted therefor
    • A61B17/58Surgical instruments or methods for treatment of bones or joints; Devices specially adapted therefor for osteosynthesis, e.g. bone plates, screws, setting implements or the like
    • A61B17/68Internal fixation devices, including fasteners and spinal fixators, even if a part thereof projects from the skin
    • A61B17/84Fasteners therefor or fasteners being internal fixation devices
    • A61B17/842Flexible wires, bands or straps
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00Surgical instruments, devices or methods, e.g. tourniquets
    • A61B2017/00004(bio)absorbable, (bio)resorbable, resorptive
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00Surgical instruments, devices or methods, e.g. tourniquets
    • A61B17/04Surgical instruments, devices or methods, e.g. tourniquets for suturing wounds; Holders or packages for needles or suture materials
    • A61B17/06Needles ; Sutures; Needle-suture combinations; Holders or packages for needles or suture materials
    • A61B2017/06052Needle-suture combinations in which a suture is extending inside a hollow tubular needle, e.g. over the entire length of the needle
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10STECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S606/00Surgery
    • Y10S606/902Cortical plate specifically adapted for a particular bone
    • Y10S606/903Cranial and facial plate
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10STECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S606/00Surgery
    • Y10S606/907Composed of particular material or coated
    • Y10S606/908Bioabsorbable material
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10STECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S606/00Surgery
    • Y10S606/907Composed of particular material or coated
    • Y10S606/91Polymer

Definitions

  • the general field to which the invention relates is absorbable polymer plates.
  • absorbable polyester matrices for use in a plating system for the fixation of bone and cartilage, especially hard tissue of the cranium, face and other plastic/reconstructive procedures.
  • Synthetic absorbable biocompatible polymers are well known in the art. Such polymers are typically used to manufacture medical devices, which are implanted in body tissue and absorb over time. Synthetic absorbable biocompatible polymers include homopolymers, copolymers (random, block, segmented and graft) of monomers such as glycolic acid, glycolide, lactic acid, lactide (d, l, meso and mixtures thereof), ⁇ -caprolactone, trimethylene carbonate and p-dioxanone. Numerous U.S. Patents describe these polymers including U.S. Pat. Nos. 5,431,679; 5,403,347; 5,314,989; 5,431,679; 5,403,347; and 5,502,159.
  • U.S. Pat. No. 4,905,680 describes an absorbable bone plate having an elongated body with lower and upper surfaces and a plurality of screw holes where the width of the plate and its thickness is extended around the screw holes to add reinforcement so that stresses surrounding the screw holes are not significantly greater than those developed in any unreinforced area of the plate.
  • U.S. Pat. No. 5,057,111 describes a non-stress shielding bone fracture healing compression plate with at least two openings to attach it to the bone tissue where at least one opening is designed with a relaxation section. When the plate begins to creep under load the stresses can be transferred to the bone so that stress shielding will not occur.
  • U.S. Pat. No. 5,275,601 describes a self locking absorbable bone screw and plate system where the head has three dimensional corrugations that when driven into the plate locks it into similar corrugations found on the plate.
  • the plate additionally has undercuts or three-dimensional conical or pyramidal elements to decrease contact area between the bone and the plate.
  • U.S. Pat. Nos. 5,290,281 and 5,607,427 describe a surgical plating system that includes a thermoplastic, absorbable plate with a plurality of concave formations and through-bore holes arranged in an alternating fashion along the plate; fasteners that are inserted through the bore holes to secure the plate to the tissue; and a heating wand with a tip adapted to mate with the concave formations to heat and bend the plate to conform it to the contours of the tissue.
  • U.S. Pat. No. 5,569,250 describes a biocompatible osetosynthesis plate secured to a plurality of bone portions.
  • the plate has an elongated section with a top and bottom face, at least one fastener opening between the faces and means for permitting additional fastener openings to be formed during the surgical procedure.
  • the plate additionally can be converted from one thermochemical state to another by application of heat to deform it prior to fixation.
  • the plates also have raised surfaces or rails disposed upon the top face to enhance rigidity.
  • the surgical plates of the present invention provide means to the surgeon to secure soft tissue to the plating system.
  • a biocompatible plate has an upper surface, a lower surface, and fastener openings extending through the plates from the upper surface to the lower surface wherein the plate has channels for attaching sutures to the plate thereby allowing the suture to closely nestle against the plate for better post-surgical cosmesis.
  • a biocompatible plate in another embodiment, has an upper surface, a lower surface, and fastener openings extending through the plates from the upper surface to the lower surface wherein the plate has risers extending from the lower surface.
  • FIG. 1 is a perspective view of the upper surface of a biocompatible, absorbable plating device of the present invention.
  • FIG. 2 is a perspective view of the lower surface of a biocompatible, absorbable plating device of the present invention.
  • FIG. 3 is a perspective view of the lower surface of an alternative embodiment of a biocompatible, absorbable plating device of the present invention.
  • FIG. 4 is a perspective view of the upper surface of another alternative embodiment of a biocompatible, absorbable plating device of the present invention.
  • the present invention discloses a plate 2 made of bioabsorbable material consisting of one or a plurality of fastener openings 4 extending through the upper surface 3 to the lower surface 5 of the plate 2.
  • Fastener 7 may be passed through the fastener openings 4 to attach the plate 2 into hard tissue such as bone 16.
  • the plates illustrated in FIGS. 1-3 have multiple lobes 8.
  • the plates 2 used in the present invention may have a variety of shapes such as multi-lobed plates (illustrated in FIGS. 1-3), I, T, Y, L, H, X, square, triangular, or circular (as are illustrated in U.S. Pat. No. 5,569,250 hereby incorporated by reference herein).
  • the inner surface 9 of the fastener openings 4 be sloped to mate with a conical surface on the head of the fastener 7 such that said head may be flush with the upper surface 3 of the plate 2 when deployed.
  • the plate 2 has one or more channels 6 through which sutures 11 may be placed to use in anchoring tissue 14 to the plate 2.
  • These sutures 11 could be pre-threaded into the plates prior to use to facilitate ease of use in surgical procedures.
  • these channels may extend only part way across and through the plate 2 or may traverse the plate (externally or internally) as shown in FIGS. 2 and 4.
  • These plates are particularly well adapted to attaching tissue such as dermis, muscle or tendon tissue to a surface of the plate 2. These plates 2 would be especially desirable for use in facial reconstruction.
  • the plate 2 has protrusions or risers 10 extending from the lower surface 5 of the plate 2 which serve to capture and provide a space for the tissue underneath the plate 2 when it is fastened to bone.
  • the risers 10 may have a variety of shapes and be positioned in various patterns to facilitate tissue reattachment and maintenance of tissue viability.
  • the tissue directly beneath the riser will be trapped between the bone and the riser 10.
  • the trapped tissue will be secured in position, which is one method for reattaching ligaments to bone.
  • the tissue that occupies the space created by the riser between the lower surface 5 of the plate 2 and the bone will be capable of remaining viable.
  • channels may also be used with the risers to secure to the upper and lower surface of the plates.
  • the plates of the present invention may be made from a variety of biocompatible materials. These biocompatible materials may be non-absorbable or absorbable.
  • the non-absorbable materials include metals and polymers. Suitable biocompatible metals include, but are not limited to metals selected from the group consisting of stainless steel, titanium and tantalum.
  • suitable biocompatible non-absorbable polymers with relatively low chronic tissue response include but are not limited to polymers selected from the group consisting of polyurethanes, polyolefins, polyesters, poly(meth)acrylates, polyvinyl fluorides, nylons and combinations thereof.
  • Suitable polymers include but are not limited to polymers selected from the group consisting of polyolefins (such as polyethylene and polypropylene including atactic, isotactic, syndiotactic, and blends thereof as well as, polyisobutylene and ethylene-alphaolefins copolymers); polyesters (such as polyethylene terephthalate and polybutylene terephthalate); acrylic polymers and copolymers, vinyl halide polymers and copolymers (such as polyvinyl chloride); polyvinyl ethers (such as polyvinyl methyl ether); polyvinylidene halides (such as polyvinylidene fluoride and polyvinylidene chloride); polyacrylonitrile; polyvinyl ketones; polyvinyl aromatics (such as polystyrene); polyvinyl esters (such as polyvinyl acetate); copolymers of vinyl monomers with each other and olefins, (such as
  • Polyamides for the purpose of this application would also includes polyamides of the form-NH--(CH 2 ) n --CO-- and NH--(CH 2 ) x --NH--CO--(CH 2 ) y --CO, wherein n is preferably an integer in from 6 to 13; x is an integer in the range of form 6 to 12; and y is an integer in the range of from 4 to 16.
  • n is preferably an integer in from 6 to 13; x is an integer in the range of form 6 to 12; and y is an integer in the range of from 4 to 16.
  • Suitable biocompatible absorbable materials from which the plate may be formed include biocompatible absorbable polymers selected from the group consisting of: aliphatic polyesters; polyorthoesters; polyanhydrides; polycarbonates; polyurethanes; polyamides; polyalkylene oxides; and combinations thereof.
  • the orthopedic plate of the present invention can also be formed from absorbable glasses or ceramics comprising calcium phosphates and other biocompatible metal oxides (i.e., CaO).
  • the plate of the present invention can further comprise combination of absorbable ceramics, glasses and polymers.
  • the orthopedic plate will be formed from an aliphatic polyester(a) and blends thereof.
  • the aliphatic polyesters are typically synthesized in a ring opening polymerization.
  • Suitable monomers include but are not limited to lactic acid, lactide (including L-, D-, meso and D,L mixtures), glycolic acid, glycolide, ⁇ -caprolactone, p-dioxanone (1,4-dioxan-2-one), trimethylene carbonate (1,3-dioxan-2-one), delta-valerolactone, beta-butyrolactone, epsilon-decalactone, 2,5-diketomorpholine, pivalolactone, alpha, alpha-diethylpropiolactone, ethylene carbonate, ethylene oxalate, 3-methyl-1,4-dioxane-2,5-dione, 3,3-diethyl-1,4-dioxan-2,5-dione,
  • the organometallic catalyst is preferably tin based, e.g., stannous octoate, and is present in the monomer mixture at a molar ratio of monomer to catalyst ranging from about 10,000/1 to about 100,000/1.
  • the initiator is typically an alkanol (including diols and polyols), a glycol, a hydroxyacid, or an amine, and is present in the monomer mixture at a molar ratio of monomer to initiator ranging from about 100/1 to about 5000/1.
  • the polymerization is typically carried out at a temperature range from about 80° C. to about 240° C., preferably from about 100° C. to about 220° C., until the desired molecular weight and viscosity are achieved.
  • the polymer blends of the present invention are manufactured in a conventional manner, preferably in the following manner.
  • the homopolymers and copolymers, prepared as described above, are individually charged into a conventional mixing vessel or reactor vessel having a conventional mixing device mounted therein, such as an impeller or equivalents thereof.
  • the polymers and copolymers are mixed at a temperature of about 100° C. to about 230° C., more preferably from about 160° C. to about 200° C., for about 5 to about 90 minutes, more preferably for about 10 to about 45 minutes, until a uniformly dispersed polymer blend is obtained.
  • the polymer blend is further processed by removing it from the mixing device, cooling to room temperature, grinding, and drying under pressures below atmospheric at elevated temperatures for a period of time using conventional apparatuses and processes.
  • the polymers and blends composed of glycolide, ⁇ -caprolactone, p-dioxanone, lactide and trimethylene carbonate will typically have a weight average molecular weight of about 20,000 grams per mole to about 300,000 grams per mole, more typically about 40,000 grams per mole to about 200,000 grams per mole, and preferably about 60,000 grams per mole to about 150,000 grams per mole.
  • molecular weights provide an inherent viscosity between about 0.5 to about 4.0 deciliters per gram (dL/g), more typically about 0.7 to about 3.5 dL/g, and most preferably about 1.0 to about 3.0 dL/g as measured in a 0.1 g/dL solution of hexafluoroisopropanol (HFIP) at 25° C. Also, it should be noted that under the above-described conditions, the residual monomer content would be less than about 5 weight percent.
  • dL/g deciliters per gram
  • HFIP hexafluoroisopropanol
  • Articles such as the absorbable plates of the present invention are molded from the polymers and blends of the present invention by use of various injection and extrusion molding equipment equipped with dry nitrogen atmospheric chamber(s) at temperatures ranging from about 100° C. to about 230° C., more preferably 140° C. to about 200° C., with residence times of about 1 to about 20 minutes, more preferably about 2 to about 10 minutes.
  • the absorbable plates of the present invention can be molded from the polymers and blends of the present invention by use of compression molding equipment equipped with a nitrogen chamber to maintain an inert atmosphere at temperatures ranging from about 100° C. to about 230° C., more preferably 140° C. to about 200° C., with residence times of about 1 to about 20 minutes, more preferably about 2 to about 10 minutes at a pressure of about 100 lbs. to about 25000 lbs., more preferably 1000 lbs. to about 10000 lbs., to form plaques.
  • the plaques would be then machined using various machining equipment to form various shaped articles.
  • the plate after molding will be sterilized by conventional means and packaged in an appropriate container for use in a surgical setting.
  • the plate is coated with or if made from a polymer or polymer blend can also contain a pharmaceutically active compound or therapeutic agent.
  • a pharmaceutically active compound or therapeutic agent can also contain a pharmaceutically active compound or therapeutic agent.
  • therapeutic agents which may be administered via this invention include, without limitation: antiinfectives such as antibiotics and antiviral agents; analgesics and analgesic combinations; antiinflammatory agents; hormones such as steroids; bone regenerating growth factors; and naturally derived or genetically engineered proteins, polysaccharides, glycoproteins, or lipoproteins.
  • Matrix formulations may be formulated by mixing one or more therapeutic agents with a polymer (such as an aliphatic polyester).
  • the therapeutic agent may be present as a liquid, a finely divided solid, or any other appropriate physical form.
  • the matrix will include one or more additives, such as diluents, carriers, excipients, stabilizers or the like.
  • the amount of therapeutic agent will depend on the particular drug being employed and medical condition being treated. Typically, the amount of drug represents about 0.001% to about 70%, more typically about 0.001% to about 50%, most typically about 0.001% to about 20% by weight of the matrix.
  • the quantity and type of drug incorporated into the delivery matrix will vary depending on the release profile desired and the amount of drug employed.
  • aliphatic polyesters Upon contact with body fluids, aliphatic polyesters undergoes gradual degradation (mainly through hydrolysis) with concomitant release of the dispersed drug for a sustained or extended period. This can result in prolonged delivery (over, say 1 to 5,000 hours, preferably 2 to 800 hours) of effective amounts (say, 0.0001 mg/kg/hour to 10 mg/kg/hour) of the drug.
  • This dosage form can be administered as is necessary depending on the subject being treated, the severity of the affliction, the judgment of the prescribing physician, and the like.
  • a biocompatible dye could be added to the polymer used to make the device during processing in order to make it more visible in the surgical field.
  • radio-opaque markers may be added to the plate to allow imaging after implantation.
  • the examples describe a biocompatible, absorbable plating system that comprises a polymer, copolymer or polymer blend that has unique soft tissue fixation characteristics.
  • the high molecular weight aliphatic polyesters are prepared by a method consisting of reacting lactone monomers via a ring opening polymerization at temperatures of 100° C. to 230° C. for 2 to 24 hours under an inert nitrogen atmosphere until the desired molecular weight and viscosity are achieved.
  • the polymer blends of the present invention are prepared by individually charging the synthesized aliphatic homo- and co-polymers into a conventional mixing vessel.
  • the homopolymers and copolymers are mixed at a temperature of 100° C. to 230° C., for 5 to 90 minutes until a uniformly dispersed polymer blend is obtained.
  • the absorbable plates of the present invention are molded from the polymers and blends of the present invention by use of various injection and extrusion molding equipment equipped with dry nitrogen atmospheric chamber(s) at temperatures ranging from 100° C. to 230° C., with residence times of 1 to 20 minutes.
  • the absorbable plates of the present invention can be molded from the polymers and blends of the present invention by use of compression molding equipment equipped with a nitrogen chamber to maintain an inert atmosphere at temperatures ranging from 100° C. to about 230° C., with residence times of about 1 to about 20 minutes at a pressure of 5000 lbs. to form plaques.
  • the plaques are then machined using various machining equipment to from various shaped articles.
  • the blends, polymers and monomers were characterized for chemical composition and purity (NMR, FT-IR), thermal analysis (DSC), melt rheology (melt stability and viscosity), molecular weight (inherent viscosity), and baseline mechanical properties (Instron stress/strain).
  • Inherent viscosities (I.V., dL/g) of the blends and polymers were measured using a 50 bore Cannon-Ubbelhode dilution viscometer immersed in a thermostatically controlled water bath at 25° C. utilizing chloroform or HFIP as the solvent at a concentration of 0.1 g/dL.
  • the assembly was then placed in a high temperature oil bath at 185° C.
  • the stirred monomers quickly began to melt.
  • the low viscosity melt quickly increased in viscosity.
  • Mechanical stirring of the high viscosity melt was continued for a total reaction time of 4 hours.
  • the 85:15 (mol/mol) poly(lactide-co-glycolide) copolymer is removed from the bath, cooled to room temperature under a stream of nitrogen, isolated and ground. The polymer was then dried under vacuum at 110° C. for 24 hours. Inherent viscosity using HFIP as a solvent is 1.90 dL/g.
  • 1.5 Kg of the polymer as formed in Example 1 is added to a nitrogen purged hopped of a 28 ton Engel injection molder equipped with an 18 mm diameter barrel to form a circular plate as shown in FIG. 1.
  • Two heating zones of 170° C., and 170° C. were employed to melt the blend as it entered the barrel.
  • a nozzle temperature of 170° C. with an injection pressure of 500 psi and a speed of 2 in/s were used to feed the molten material down the barrel.
  • Each injection produced a single part in a single cavity mold.
  • a temperature of 30° C. was used in the mold to optimize the stress levels in the part. Using this process 2 parts are formed per minute.
  • a circular burr hole cover plate (as illustrated in FIG. 1) is manufactured from the matrix described in Example 1 by the injection molding process described in Example 2.
  • the plate is immersed in a vessel containing a biocompatible heat transfer medium (i.e. warm water) at a temperature of about 50-60° C.
  • a biocompatible heat transfer medium i.e. warm water
  • the surgeon shapes the plate by bending it without causing damage to the plate.
  • the surgeon secures the soft tissue to the plate and then the plate to the fracture site in a conventional manner using conventional fasteners (i.e. screws, rivets).

Abstract

An absorbable biocompatible polymeric plate is described. The plate has channels on its top surface and through its thickness for receiving sutures to secure soft tissue proximally to the device. The plate also has notches on its bottom surface for added security of soft tissue when conditions require the surgeon to attach tissue beneath the plate.

Description

FIELD OF THE INVENTION
The general field to which the invention relates is absorbable polymer plates. Specifically, absorbable polyester matrices for use in a plating system for the fixation of bone and cartilage, especially hard tissue of the cranium, face and other plastic/reconstructive procedures.
BACKGROUND OF THE INVENTION
Synthetic absorbable biocompatible polymers are well known in the art. Such polymers are typically used to manufacture medical devices, which are implanted in body tissue and absorb over time. Synthetic absorbable biocompatible polymers include homopolymers, copolymers (random, block, segmented and graft) of monomers such as glycolic acid, glycolide, lactic acid, lactide (d, l, meso and mixtures thereof), ε-caprolactone, trimethylene carbonate and p-dioxanone. Numerous U.S. Patents describe these polymers including U.S. Pat. Nos. 5,431,679; 5,403,347; 5,314,989; 5,431,679; 5,403,347; and 5,502,159.
Plating systems comprising such polymers have also been described. U.S. Pat. No. 4,905,680 describes an absorbable bone plate having an elongated body with lower and upper surfaces and a plurality of screw holes where the width of the plate and its thickness is extended around the screw holes to add reinforcement so that stresses surrounding the screw holes are not significantly greater than those developed in any unreinforced area of the plate.
U.S. Pat. No. 5,057,111 describes a non-stress shielding bone fracture healing compression plate with at least two openings to attach it to the bone tissue where at least one opening is designed with a relaxation section. When the plate begins to creep under load the stresses can be transferred to the bone so that stress shielding will not occur.
U.S. Pat. No. 5,275,601 describes a self locking absorbable bone screw and plate system where the head has three dimensional corrugations that when driven into the plate locks it into similar corrugations found on the plate. The plate additionally has undercuts or three-dimensional conical or pyramidal elements to decrease contact area between the bone and the plate.
U.S. Pat. Nos. 5,290,281 and 5,607,427 describe a surgical plating system that includes a thermoplastic, absorbable plate with a plurality of concave formations and through-bore holes arranged in an alternating fashion along the plate; fasteners that are inserted through the bore holes to secure the plate to the tissue; and a heating wand with a tip adapted to mate with the concave formations to heat and bend the plate to conform it to the contours of the tissue.
U.S. Pat. No. 5,569,250 describes a biocompatible osetosynthesis plate secured to a plurality of bone portions. The plate has an elongated section with a top and bottom face, at least one fastener opening between the faces and means for permitting additional fastener openings to be formed during the surgical procedure. The plate additionally can be converted from one thermochemical state to another by application of heat to deform it prior to fixation. The plates also have raised surfaces or rails disposed upon the top face to enhance rigidity.
Unfortunately, these patents do not recognize the need for a device that allows a method by which to secure soft tissue to the plate. This is critical, especially in plastic reconstructive procedures where soft tissue needs to be reattached near its original anatomical position to provide proper support during healing and improved post-surgical cosmesis.
The surgical plates of the present invention provide means to the surgeon to secure soft tissue to the plating system.
SUMMARY OF THE INVENTION
We have discovered an absorbable polymer plating system that provides means by which to secure soft tissue to the plates.
In one embodiment, a biocompatible plate is provided that has an upper surface, a lower surface, and fastener openings extending through the plates from the upper surface to the lower surface wherein the plate has channels for attaching sutures to the plate thereby allowing the suture to closely nestle against the plate for better post-surgical cosmesis.
In another embodiment, a biocompatible plate is provided that has an upper surface, a lower surface, and fastener openings extending through the plates from the upper surface to the lower surface wherein the plate has risers extending from the lower surface.
The foregoing and other features and advantages of the invention will become more apparent from the following description and accompanying examples.
BRIEF DESCRIPTION OF THE DRAWINGS
FIG. 1 is a perspective view of the upper surface of a biocompatible, absorbable plating device of the present invention.
FIG. 2 is a perspective view of the lower surface of a biocompatible, absorbable plating device of the present invention.
FIG. 3 is a perspective view of the lower surface of an alternative embodiment of a biocompatible, absorbable plating device of the present invention.
FIG. 4 is a perspective view of the upper surface of another alternative embodiment of a biocompatible, absorbable plating device of the present invention.
DETAILED DESCRIPTION OF THE INVENTION
As is illustrated in FIGS. 1-3 the present invention discloses a plate 2 made of bioabsorbable material consisting of one or a plurality of fastener openings 4 extending through the upper surface 3 to the lower surface 5 of the plate 2. Fastener 7 may be passed through the fastener openings 4 to attach the plate 2 into hard tissue such as bone 16. The plates illustrated in FIGS. 1-3 have multiple lobes 8. However, the plates 2 used in the present invention may have a variety of shapes such as multi-lobed plates (illustrated in FIGS. 1-3), I, T, Y, L, H, X, square, triangular, or circular (as are illustrated in U.S. Pat. No. 5,569,250 hereby incorporated by reference herein). It is preferred, that the inner surface 9 of the fastener openings 4 be sloped to mate with a conical surface on the head of the fastener 7 such that said head may be flush with the upper surface 3 of the plate 2 when deployed.
In one embodiment of the present invention, illustrated in FIGS. 1, 2 and 4 the plate 2 has one or more channels 6 through which sutures 11 may be placed to use in anchoring tissue 14 to the plate 2. These sutures 11 of course could be pre-threaded into the plates prior to use to facilitate ease of use in surgical procedures. As is shown in FIG. 1 these channels may extend only part way across and through the plate 2 or may traverse the plate (externally or internally) as shown in FIGS. 2 and 4. These plates are particularly well adapted to attaching tissue such as dermis, muscle or tendon tissue to a surface of the plate 2. These plates 2 would be especially desirable for use in facial reconstruction.
In another embodiment, illustrated in FIG. 3, the plate 2 has protrusions or risers 10 extending from the lower surface 5 of the plate 2 which serve to capture and provide a space for the tissue underneath the plate 2 when it is fastened to bone. The risers 10 may have a variety of shapes and be positioned in various patterns to facilitate tissue reattachment and maintenance of tissue viability. The tissue directly beneath the riser will be trapped between the bone and the riser 10. The trapped tissue will be secured in position, which is one method for reattaching ligaments to bone. The tissue that occupies the space created by the riser between the lower surface 5 of the plate 2 and the bone will be capable of remaining viable. Additionally, channels may also be used with the risers to secure to the upper and lower surface of the plates.
The plates of the present invention may be made from a variety of biocompatible materials. These biocompatible materials may be non-absorbable or absorbable. The non-absorbable materials include metals and polymers. Suitable biocompatible metals include, but are not limited to metals selected from the group consisting of stainless steel, titanium and tantalum.
Examples of suitable biocompatible non-absorbable polymers with relatively low chronic tissue response include but are not limited to polymers selected from the group consisting of polyurethanes, polyolefins, polyesters, poly(meth)acrylates, polyvinyl fluorides, nylons and combinations thereof. Suitable polymers include but are not limited to polymers selected from the group consisting of polyolefins (such as polyethylene and polypropylene including atactic, isotactic, syndiotactic, and blends thereof as well as, polyisobutylene and ethylene-alphaolefins copolymers); polyesters (such as polyethylene terephthalate and polybutylene terephthalate); acrylic polymers and copolymers, vinyl halide polymers and copolymers (such as polyvinyl chloride); polyvinyl ethers (such as polyvinyl methyl ether); polyvinylidene halides (such as polyvinylidene fluoride and polyvinylidene chloride); polyacrylonitrile; polyvinyl ketones; polyvinyl aromatics (such as polystyrene); polyvinyl esters (such as polyvinyl acetate); copolymers of vinyl monomers with each other and olefins, (such as etheylene-methyl methacrylate copolymers, acrylonitrile-styrene copolymers, ABS resins and ethylene-vinyl acetate copolymers); polyamides (such as nylon 4, nylon 6, nylon 66, nylon 610, nylon 11, nylon 12 and polycaprolactam); alkyd resins; polycarbonates; polyoxymethylenes; polyimides; polyethers; epoxy resins, polyurethanes; rayon; and rayon-triacetate. Polyamides for the purpose of this application would also includes polyamides of the form-NH--(CH2)n --CO-- and NH--(CH2)x --NH--CO--(CH2)y --CO, wherein n is preferably an integer in from 6 to 13; x is an integer in the range of form 6 to 12; and y is an integer in the range of from 4 to 16. The list provided above is illustrative but not limiting.
Suitable biocompatible absorbable materials from which the plate may be formed include biocompatible absorbable polymers selected from the group consisting of: aliphatic polyesters; polyorthoesters; polyanhydrides; polycarbonates; polyurethanes; polyamides; polyalkylene oxides; and combinations thereof. The orthopedic plate of the present invention can also be formed from absorbable glasses or ceramics comprising calcium phosphates and other biocompatible metal oxides (i.e., CaO). The plate of the present invention can further comprise combination of absorbable ceramics, glasses and polymers.
In a preferred embodiment, the orthopedic plate will be formed from an aliphatic polyester(a) and blends thereof. The aliphatic polyesters are typically synthesized in a ring opening polymerization. Suitable monomers include but are not limited to lactic acid, lactide (including L-, D-, meso and D,L mixtures), glycolic acid, glycolide, ε-caprolactone, p-dioxanone (1,4-dioxan-2-one), trimethylene carbonate (1,3-dioxan-2-one), delta-valerolactone, beta-butyrolactone, epsilon-decalactone, 2,5-diketomorpholine, pivalolactone, alpha, alpha-diethylpropiolactone, ethylene carbonate, ethylene oxalate, 3-methyl-1,4-dioxane-2,5-dione, 3,3-diethyl-1,4-dioxan-2,5-dione, gamma-butyrolactone, 1,4-dioxepan-2-one, 1,5-dioxepan-2-one, 6,6-dimethyl-dioxepan-2-one, 6,8-dioxabicycloctane-7-one and combinations thereof.
These monomers are generally polymerized in the presence of an organometallic catalyst and an initiator at elevated temperatures. The organometallic catalyst is preferably tin based, e.g., stannous octoate, and is present in the monomer mixture at a molar ratio of monomer to catalyst ranging from about 10,000/1 to about 100,000/1. The initiator is typically an alkanol (including diols and polyols), a glycol, a hydroxyacid, or an amine, and is present in the monomer mixture at a molar ratio of monomer to initiator ranging from about 100/1 to about 5000/1. The polymerization is typically carried out at a temperature range from about 80° C. to about 240° C., preferably from about 100° C. to about 220° C., until the desired molecular weight and viscosity are achieved.
The polymer blends of the present invention are manufactured in a conventional manner, preferably in the following manner. The homopolymers and copolymers, prepared as described above, are individually charged into a conventional mixing vessel or reactor vessel having a conventional mixing device mounted therein, such as an impeller or equivalents thereof. Then, the polymers and copolymers are mixed at a temperature of about 100° C. to about 230° C., more preferably from about 160° C. to about 200° C., for about 5 to about 90 minutes, more preferably for about 10 to about 45 minutes, until a uniformly dispersed polymer blend is obtained. Then, the polymer blend is further processed by removing it from the mixing device, cooling to room temperature, grinding, and drying under pressures below atmospheric at elevated temperatures for a period of time using conventional apparatuses and processes.
Under the above described conditions, the polymers and blends composed of glycolide, ε-caprolactone, p-dioxanone, lactide and trimethylene carbonate will typically have a weight average molecular weight of about 20,000 grams per mole to about 300,000 grams per mole, more typically about 40,000 grams per mole to about 200,000 grams per mole, and preferably about 60,000 grams per mole to about 150,000 grams per mole. These molecular weights provide an inherent viscosity between about 0.5 to about 4.0 deciliters per gram (dL/g), more typically about 0.7 to about 3.5 dL/g, and most preferably about 1.0 to about 3.0 dL/g as measured in a 0.1 g/dL solution of hexafluoroisopropanol (HFIP) at 25° C. Also, it should be noted that under the above-described conditions, the residual monomer content would be less than about 5 weight percent.
Articles such as the absorbable plates of the present invention are molded from the polymers and blends of the present invention by use of various injection and extrusion molding equipment equipped with dry nitrogen atmospheric chamber(s) at temperatures ranging from about 100° C. to about 230° C., more preferably 140° C. to about 200° C., with residence times of about 1 to about 20 minutes, more preferably about 2 to about 10 minutes.
In addition, the absorbable plates of the present invention can be molded from the polymers and blends of the present invention by use of compression molding equipment equipped with a nitrogen chamber to maintain an inert atmosphere at temperatures ranging from about 100° C. to about 230° C., more preferably 140° C. to about 200° C., with residence times of about 1 to about 20 minutes, more preferably about 2 to about 10 minutes at a pressure of about 100 lbs. to about 25000 lbs., more preferably 1000 lbs. to about 10000 lbs., to form plaques. The plaques would be then machined using various machining equipment to form various shaped articles.
The plate after molding will be sterilized by conventional means and packaged in an appropriate container for use in a surgical setting.
In another embodiment of the present invention, the plate is coated with or if made from a polymer or polymer blend can also contain a pharmaceutically active compound or therapeutic agent. The variety of different therapeutic agents that can be used in conjunction with the polymers of the present invention is vast. In general, therapeutic agents which may be administered via this invention include, without limitation: antiinfectives such as antibiotics and antiviral agents; analgesics and analgesic combinations; antiinflammatory agents; hormones such as steroids; bone regenerating growth factors; and naturally derived or genetically engineered proteins, polysaccharides, glycoproteins, or lipoproteins.
Matrix formulations may be formulated by mixing one or more therapeutic agents with a polymer (such as an aliphatic polyester). The therapeutic agent, may be present as a liquid, a finely divided solid, or any other appropriate physical form. Typically, but optionally, the matrix will include one or more additives, such as diluents, carriers, excipients, stabilizers or the like.
The amount of therapeutic agent will depend on the particular drug being employed and medical condition being treated. Typically, the amount of drug represents about 0.001% to about 70%, more typically about 0.001% to about 50%, most typically about 0.001% to about 20% by weight of the matrix.
The quantity and type of drug incorporated into the delivery matrix will vary depending on the release profile desired and the amount of drug employed.
Upon contact with body fluids, aliphatic polyesters undergoes gradual degradation (mainly through hydrolysis) with concomitant release of the dispersed drug for a sustained or extended period. This can result in prolonged delivery (over, say 1 to 5,000 hours, preferably 2 to 800 hours) of effective amounts (say, 0.0001 mg/kg/hour to 10 mg/kg/hour) of the drug. This dosage form can be administered as is necessary depending on the subject being treated, the severity of the affliction, the judgment of the prescribing physician, and the like.
Following this or similar procedures, those skilled in the art will be able to prepare a variety of formulations.
In another embodiment of the present plate invention, a biocompatible dye could be added to the polymer used to make the device during processing in order to make it more visible in the surgical field. Additionally, radio-opaque markers may be added to the plate to allow imaging after implantation.
The following non-limiting examples are illustrative of the principles and practice of this invention. Numerous additional embodiments within the scope and spirit of the invention will become apparent to those skilled in the art.
EXAMPLES
The examples describe a biocompatible, absorbable plating system that comprises a polymer, copolymer or polymer blend that has unique soft tissue fixation characteristics.
In the synthetic process, the high molecular weight aliphatic polyesters are prepared by a method consisting of reacting lactone monomers via a ring opening polymerization at temperatures of 100° C. to 230° C. for 2 to 24 hours under an inert nitrogen atmosphere until the desired molecular weight and viscosity are achieved.
The polymer blends of the present invention are prepared by individually charging the synthesized aliphatic homo- and co-polymers into a conventional mixing vessel. The homopolymers and copolymers are mixed at a temperature of 100° C. to 230° C., for 5 to 90 minutes until a uniformly dispersed polymer blend is obtained.
The absorbable plates of the present invention are molded from the polymers and blends of the present invention by use of various injection and extrusion molding equipment equipped with dry nitrogen atmospheric chamber(s) at temperatures ranging from 100° C. to 230° C., with residence times of 1 to 20 minutes.
In addition, the absorbable plates of the present invention can be molded from the polymers and blends of the present invention by use of compression molding equipment equipped with a nitrogen chamber to maintain an inert atmosphere at temperatures ranging from 100° C. to about 230° C., with residence times of about 1 to about 20 minutes at a pressure of 5000 lbs. to form plaques. The plaques are then machined using various machining equipment to from various shaped articles.
In the examples which follow, the blends, polymers and monomers were characterized for chemical composition and purity (NMR, FT-IR), thermal analysis (DSC), melt rheology (melt stability and viscosity), molecular weight (inherent viscosity), and baseline mechanical properties (Instron stress/strain).
Inherent viscosities (I.V., dL/g) of the blends and polymers were measured using a 50 bore Cannon-Ubbelhode dilution viscometer immersed in a thermostatically controlled water bath at 25° C. utilizing chloroform or HFIP as the solvent at a concentration of 0.1 g/dL.
Several examples will be described in the following few pages. Parts and percentages where used are parts and percentages as specified as weight or moles.
Example 1 Synthesis of a 85:15 (mol/mol) poly(lactide-co-glycolide) copolymer
The method described below and utilized in this example is similar to those described in U.S. Pat. Nos. 4,643,191, 4,653,497, 5,007,923, 5,047,048 which are incorporated by reference, and is known to those skilled in the art.
To a flame dried 500 mL 1-neck round bottom flask equipped with an overhead mechanical stirrer and nitrogen inlet, 268 grams (1.86 moles) of L(-) lactide, 38.4 grams (0.330 moles) of glycolide, 0.53 grams (7×10-3 moles) of glycolic acid initiator, and 131 microliters of a 0.33 M solution of stannous octoate catalyst are added.
The assembly was then placed in a high temperature oil bath at 185° C. The stirred monomers quickly began to melt. The low viscosity melt quickly increased in viscosity. Mechanical stirring of the high viscosity melt was continued for a total reaction time of 4 hours.
The 85:15 (mol/mol) poly(lactide-co-glycolide) copolymer is removed from the bath, cooled to room temperature under a stream of nitrogen, isolated and ground. The polymer was then dried under vacuum at 110° C. for 24 hours. Inherent viscosity using HFIP as a solvent is 1.90 dL/g.
Example 2 Injection molding a circular plate (of FIG. 1) of a 85:15 poly(lactide-co-glycolide) copolymer
1.5 Kg of the polymer as formed in Example 1 is added to a nitrogen purged hopped of a 28 ton Engel injection molder equipped with an 18 mm diameter barrel to form a circular plate as shown in FIG. 1. Two heating zones of 170° C., and 170° C. were employed to melt the blend as it entered the barrel. A nozzle temperature of 170° C. with an injection pressure of 500 psi and a speed of 2 in/s were used to feed the molten material down the barrel. Each injection produced a single part in a single cavity mold. A temperature of 30° C. was used in the mold to optimize the stress levels in the part. Using this process 2 parts are formed per minute.
Example 3 Compression molding and machining a circular plate (of FIG. 1) of a 85:15 poly(lactide-co-glycolide) copolymer
32 grams of a 85:15 poly(lactide-co-glycolide) copolymer is placed on a 6"×6" metal platen. A 6"×6" metal schimm is placed around the polymer and then a second 6"×6" metal platen is placed on top of the other metal platen, the schimm and the polymer. The entire assembly is then placed in a Tetrahedron compression molding press equipped with a nitrogen chamber to maintain an inert atmosphere. The temperature of the press is slowly ramped up to 185° C. After 10 minutes at 185° C., the polymer becomes molten and 5000 lbs. of pressure is slowly applied. The pressure and temperature are maintained for ten minutes. The press is then cooled to room temperature and the plaque is removed from the platen assembly. The plaque is then machined into various plate geometries and sizes.
Example 4
A circular burr hole cover plate (as illustrated in FIG. 1) is manufactured from the matrix described in Example 1 by the injection molding process described in Example 2. The plate is immersed in a vessel containing a biocompatible heat transfer medium (i.e. warm water) at a temperature of about 50-60° C. The surgeon shapes the plate by bending it without causing damage to the plate. The surgeon then secures the soft tissue to the plate and then the plate to the fracture site in a conventional manner using conventional fasteners (i.e. screws, rivets).

Claims (21)

We claim:
1. A biocompatible plate having an upper surface, a lower surface, fastener openings extending through the plate from the upper surface to the lower surface; and one or more channels traversing the plate for attaching at least one suture to the plate.
2. The biocompatible plate of claim 1 wherein the channel traverses the lower surface of the biocompatible plate.
3. The biocompatible plate of claim 1 wherein the channel internally traverses the biocompatible plate.
4. The biocompatible plate of claim 1 wherein the plate is made from a biocompatible material selected from the group consisting of aliphatic polyesters; polyorthoesters; polyanhydrides; polycarbonates; polyurethanes; polyamides; polyalkylene oxides; absorbable glasses or ceramics comprising calcium phosphates; biocompatible metal oxides; and combinations thereof.
5. The biocompatible plate of claim 4 wherein the biocompatible plate is made from biocompatible aliphatic polyesters.
6. The biocompatible aliphatic polyester of claim 5 wherein the aliphatic polyester is selected from the group consisting of polylactide, polyglycolide, poly-1,4-dioxan-2-one, polytrimethylene carbonate and poly(ε-caprolactone), copolymers and blends thereof.
7. The biocompatible plate of claim 1 wherein the plate has a shape selected from the group consisting of multilobed, I, T, Y, L, H, X, square, triangular, and circular.
8. The biocompatible plate of claim 1 wherein additionally present is a pharmaceutically active compound selected from the group consisting of antiinfectives; analgesics and analgesic combinations; antiinflammatory agents; hormones; growth factors; and naturally derived or genetically engineered proteins, polysaccharides, glycoproteins, or lipoproteins.
9. The biocompatible plate of claim 1 wherein additionally present in the biocompatible plate is a radio-opaque marker.
10. The biocompatible plate of claim 1 wherein a suture is attached to the biocompatible plate.
11. A biocompatible plate having an upper surface, a lower surface, fastener openings extending through the plate from the upper surface to the lower surface, risers extending from the lower surface; and one or more channels for attaching at least one suture to the plate.
12. The biocompatible plate of claim 11 wherein the plate is made from a biocompatible material selected from the group consisting of aliphatic polyesters; polyorthoesters; polyanhydrides; polycarbonates; polyurethanes; polyamides; polyalkylene oxides; absorbable glasses or ceramics comprising calcium phosphates; biocompatible metal oxides; and combinations thereof.
13. The biocompatible plate of claim 12 wherein the biocompatible plate is made from biocompatible aliphatic polyesters.
14. The biocompatible aliphatic polymer of claim 13 wherein the aliphatic polyester is selected from the group consisting of polylactide, polyglycolide, poly-1,4-dioxan-2-one, polytrimethylene carbonate and poly(ε-caprolactone), copolymers and blends thereof.
15. The biocompatible plate of claim 11 wherein the plate has a shape selected from the group consisting of multilobed, I, T, Y, L, H, X, square, triangular, and circular.
16. The biocompatible plate of claim 11 wherein the channel extends part way across a surface of the plate and through the plate.
17. The biocompatible plate of claim 11 wherein the channel traverses the lower surface of the biocompatible plate.
18. The biocompatible plate of claim 11 wherein the channel internally traverses the biocompatible plate.
19. The biocompatible plate of claim 11 wherein additionally present is a pharmaceutically active compound selected from the group consisting of antiinfectives; analgesics and analgesic combinations; antiinflammatory agents; hormones; growth factors; and naturally derived or genetically engineered proteins, polysaccharides, glycoproteins, or lipoproteins.
20. The biocompatible plate of claim 11 wherein additionally present in the biocompatible plate is a radio-opaque marker.
21. The biocompatible plate of claim 11 wherein a suture is attached to the biocompatible plate.
US09/233,569 1999-01-19 1999-01-19 Biocompatible absorbable polymer plating system for tissue fixation Expired - Lifetime US6093201A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
US09/233,569 US6093201A (en) 1999-01-19 1999-01-19 Biocompatible absorbable polymer plating system for tissue fixation

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US09/233,569 US6093201A (en) 1999-01-19 1999-01-19 Biocompatible absorbable polymer plating system for tissue fixation

Publications (1)

Publication Number Publication Date
US6093201A true US6093201A (en) 2000-07-25

Family

ID=22877779

Family Applications (1)

Application Number Title Priority Date Filing Date
US09/233,569 Expired - Lifetime US6093201A (en) 1999-01-19 1999-01-19 Biocompatible absorbable polymer plating system for tissue fixation

Country Status (1)

Country Link
US (1) US6093201A (en)

Cited By (117)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2002026106A2 (en) * 2000-09-25 2002-04-04 Kinamed, Inc. Suspension plate for attaching the temporalis muscle supporting sutures
WO2002034159A2 (en) * 2000-10-25 2002-05-02 Sdgi Holdings, Inc. Non-metallic implant devices and intra-operative methods for assembly and fixation
US6464706B1 (en) * 1999-06-10 2002-10-15 Thomas F. Winters Tissue fixation device and method
US6514274B1 (en) * 2000-02-25 2003-02-04 Arthrotek, Inc. Method and apparatus for rotator cuff repair
US20030049299A1 (en) * 2001-07-16 2003-03-13 Prasanna Malaviya Porous delivery scaffold and method
EP1322241A1 (en) * 2000-09-20 2003-07-02 Kevin Jon Lawson Cable-anchor system for spinal fixation
US6607548B2 (en) 2001-05-17 2003-08-19 Inion Ltd. Resorbable polymer compositions
EP1321154A3 (en) * 2001-12-20 2004-01-07 Ethicon, Inc. Bioabsorbable coatings of surgical devices
US6692498B1 (en) * 2000-11-27 2004-02-17 Linvatec Corporation Bioabsorbable, osteopromoting fixation plate
US6723097B2 (en) * 2002-07-23 2004-04-20 Depuy Spine, Inc. Surgical trial implant
US20040166169A1 (en) * 2002-07-15 2004-08-26 Prasanna Malaviya Porous extracellular matrix scaffold and method
US20040193165A1 (en) * 2003-03-27 2004-09-30 Hand Innovations, Inc. Anatomical distal radius fracture fixation plate and methods of using the same
US20040193164A1 (en) * 2003-03-27 2004-09-30 Orbay Jorge L. Anatomical distal radius fracture fixation plate and methods of using the same
US20040210218A1 (en) * 2001-10-15 2004-10-21 Dixon Robert A. Vertebral implant for bone fixation or interbody use
EP1477124A1 (en) * 2003-05-12 2004-11-17 C.H. Medical Limited Fixation of fractured bones
US20040260296A1 (en) * 2003-06-18 2004-12-23 Kaiser Ryan A. Device and method of fastening a graft to a bone
US20050065524A1 (en) * 2003-03-27 2005-03-24 Orbay Jorge L. Anatomical distal radius fracture fixation plate with fixed-angle K-wire holes defining a three-dimensional surface
US20050065523A1 (en) * 2003-03-27 2005-03-24 Orbay Jorge L. Distal radius fracture fixation plate having K-wire hole structured to fix a K-wire in one dimension relative to the plate
US20050124990A1 (en) * 2003-12-09 2005-06-09 Michael Teague Bone plate holder and screw guide
US20050216008A1 (en) * 2004-03-24 2005-09-29 Zwirnmann Ralph F Bone fixation implants
US20050228500A1 (en) * 2003-08-01 2005-10-13 Spinal Kinetics, Inc. Prosthetic intervertebral disc and methods for using same
US20050228442A1 (en) * 2002-05-06 2005-10-13 Wheatley Margaret A Tissue joining devices capable of delivery of bioactive agents and methods for use thereof
US20050251143A1 (en) * 2004-05-05 2005-11-10 Dillard David G Surgical system and method of use for soft tissue fixation to bone
US20050273165A1 (en) * 2004-06-04 2005-12-08 Bryan Griffiths Soft tissue spacer
US20060015106A1 (en) * 1999-10-30 2006-01-19 Karl-Dieter Lerch Surgical connecting element for fixing adjacently arranged bone plates
US7001411B1 (en) 2000-09-25 2006-02-21 Dean John C Soft tissue cleat
US20060128296A1 (en) * 2004-10-29 2006-06-15 Schwan Wade E Intestine processing device and associated method
US20060235408A1 (en) * 2001-11-09 2006-10-19 Wang Robert C Apparatus and methods for bone fracture fixation
US20060235407A1 (en) * 2001-11-09 2006-10-19 Wang Robert C Apparatus and methods for bone fracture reduction and fixation
US20060241617A1 (en) * 2005-04-04 2006-10-26 Ashley Holloway Bone plate with suture loops
US20060247638A1 (en) * 2005-04-29 2006-11-02 Sdgi Holdings, Inc. Composite spinal fixation systems
US20060253153A1 (en) * 2005-04-22 2006-11-09 Helmut Schreiber Surgical marker/connector
US7160333B2 (en) 2000-08-04 2007-01-09 Depuy Orthopaedics, Inc. Reinforced small intestinal submucosa
US20070162019A1 (en) * 2005-12-21 2007-07-12 Paul Burns Resorbable anterior cervical plating system with screw retention mechanism
US20070167950A1 (en) * 2005-12-22 2007-07-19 Tauro Joseph C System and method for attaching soft tissue to bone
US20070270853A1 (en) * 2006-04-11 2007-11-22 Ebi, L.P. Contoured bone plate
US20070270849A1 (en) * 2006-04-21 2007-11-22 Orbay Jorge L Fixation Plate With Multifunctional Holes
US7303577B1 (en) 2003-02-05 2007-12-04 Dean John C Apparatus and method for use in repairs of injured soft tissue
US20070288023A1 (en) * 2006-06-12 2007-12-13 Greg Pellegrino Soft tissue repair using tissue augments and bone anchors
US7361195B2 (en) 2001-07-16 2008-04-22 Depuy Products, Inc. Cartilage repair apparatus and method
US20080097490A1 (en) * 2005-04-22 2008-04-24 Helmut Schreiber Method for Marking and Connecting Tissue
US20080188856A1 (en) * 2007-02-06 2008-08-07 Zimmer Gmbh Central Structures Spreader for the Lumbar Spine
US20080200955A1 (en) * 2005-02-22 2008-08-21 Kyon Plate and Screws for Treatment of Bone Fractures
US20090082816A1 (en) * 2007-09-20 2009-03-26 Graham Matthew R Remodelable orthopaedic spacer and method of using the same
US7527649B1 (en) 2002-02-15 2009-05-05 Nuvasive, Inc. Intervertebral implant and related methods
US20090216270A1 (en) * 2008-02-27 2009-08-27 Scott Humphrey Fixable suture anchor plate and method for tendon-to-bone repair
US7585311B2 (en) 2004-06-02 2009-09-08 Kfx Medical Corporation System and method for attaching soft tissue to bone
US20090234386A1 (en) * 2008-03-11 2009-09-17 Dean John C Suture Cleat for Soft Tissue Injury Repair
US20100030277A1 (en) * 2008-07-31 2010-02-04 Haidukewych George J Periarticular bone plate with biplanar offset head member
US20100030276A1 (en) * 2008-07-31 2010-02-04 Dave Huebner Periarticular Bone Plate With Biplanar Offset Head Member
US20100049247A1 (en) * 2008-08-25 2010-02-25 Daniel Larkin Suture fixation kit of parts, system, and device
US20100217392A1 (en) * 2009-02-23 2010-08-26 Bartee Barry K Reinforced ptfe medical barriers
US20100234895A1 (en) * 2009-03-13 2010-09-16 Harold Hess Dynamic Vertebral Column Plate System
US7819918B2 (en) 2001-07-16 2010-10-26 Depuy Products, Inc. Implantable tissue repair device
US20110004252A1 (en) * 2009-07-04 2011-01-06 Jordan Velikov Plate for the treatment of bone fractures
US7871440B2 (en) 2006-12-11 2011-01-18 Depuy Products, Inc. Unitary surgical device and method
US7914808B2 (en) 2001-07-16 2011-03-29 Depuy Products, Inc. Hybrid biologic/synthetic porous extracellular matrix scaffolds
US20110160856A1 (en) * 2009-07-02 2011-06-30 Medicinelodge, Inc. Dba Imds Co-Innovation Systems and Methods for Zipknot ACL Fixation
US8012205B2 (en) 2001-07-16 2011-09-06 Depuy Products, Inc. Cartilage repair and regeneration device
US20110218574A1 (en) * 2010-03-03 2011-09-08 Warsaw Orthopedic, Inc. Dynamic vertebral construct
US8025896B2 (en) 2001-07-16 2011-09-27 Depuy Products, Inc. Porous extracellular matrix scaffold and method
US8062334B2 (en) 2004-06-02 2011-11-22 Kfx Medical Corporation Suture anchor
US8092529B2 (en) 2001-07-16 2012-01-10 Depuy Products, Inc. Meniscus regeneration device
US20120029275A1 (en) * 2010-07-29 2012-02-02 Boston Scientific Scimed, Inc. Bodily implants and methods of adjusting the same
US20120046747A1 (en) * 2004-09-07 2012-02-23 Medicinelodge, Inc. Dba Imds Co-Innovation Systems and methods for zipknot acl fixation
US20120265254A1 (en) * 2006-02-24 2012-10-18 Horan Timothy J Tibial plateau leveling osteotomy plate
US20120289964A1 (en) * 2011-05-10 2012-11-15 Peter Nakaji Cranial plating and bur hole cover system and methods of use
US8337537B2 (en) 2001-07-16 2012-12-25 Depuy Products, Inc. Device from naturally occurring biologically derived materials
US8366787B2 (en) 2000-08-04 2013-02-05 Depuy Products, Inc. Hybrid biologic-synthetic bioabsorbable scaffolds
US8388655B2 (en) 2003-06-11 2013-03-05 Imds Corporation Compact line locks and methods
WO2013055858A1 (en) 2011-10-11 2013-04-18 Norris Brent Lane Low profile periarticular tension band plating system with soft tissue neutralization cable tunnel/channel
KR101277605B1 (en) * 2013-05-08 2013-06-21 ㈜ 이트리온 Plate for fixing bone and method for making the plate
US8491460B1 (en) * 2012-12-14 2013-07-23 Joseph S. Montgomery, III Method and apparatus for treating vaginal prolapse
US20130190817A1 (en) * 2012-01-24 2013-07-25 Synthes Usa, Llc Compression screw system
US8545535B2 (en) 2009-05-12 2013-10-01 Foundry Newco Xi, Inc. Suture anchors with one-way cinching mechanisms
US8574270B2 (en) 2009-03-13 2013-11-05 Spinal Simplicity Llc Bone plate assembly with bone screw retention features
US20130331848A1 (en) * 2011-10-25 2013-12-12 Biomet Sports Medicine, Llc Method And Apparatus For Intraosseous Membrane Reconstruction
US20140371798A1 (en) * 2013-06-13 2014-12-18 James Platt Channeled bone plate and methods for implanting the same
US8974504B2 (en) 2012-05-10 2015-03-10 Spinal Simplicity Llc Dynamic bone fracture plates
US20150094763A1 (en) * 2011-09-29 2015-04-02 Smith & Nephew, Inc. Attachment Device to Attach Tissue Graft
US9011494B2 (en) 2009-09-24 2015-04-21 Warsaw Orthopedic, Inc. Composite vertebral rod system and methods of use
RU2553191C2 (en) * 2013-06-13 2015-06-10 Муниципальное бюджетное учреждение здравоохранения "Городская клиническая больница N 11" Retainer for stable functional osteosynthesis of patella fractures
US20150238237A1 (en) * 2014-02-21 2015-08-27 The Charlotte-Mecklenburg Hospital Authority D/B/A Carolinas Healthcare System Bone fixation implants
CN105167834A (en) * 2015-10-30 2015-12-23 重庆医科大学附属永川医院 Inner fixing steel plate capable of promoting fracture healing for orthopaedics department
US20160066970A1 (en) * 2012-01-05 2016-03-10 The Cleveland Clinic Foundation Bone fixation apparatus
US9463010B2 (en) 2009-05-12 2016-10-11 The Foundry, Llc Methods and devices to treat diseased or injured musculoskeletal tissue
WO2016164911A3 (en) * 2015-04-10 2016-12-15 Colorado State University Research Foundation Ring-opening polymerization methods and recyclable biorenewable polyesters
US9526543B2 (en) 2004-11-10 2016-12-27 Biomet C.V. Modular fracture fixation system
US20170209195A1 (en) * 2014-07-10 2017-07-27 In2Bones Implant and surgical kit for holding bone bodies of a patient in position with respect to one another
US20170238981A1 (en) * 2014-02-21 2017-08-24 Jeko Metodiev Madjarov Bone fixation implants and methods
US20180064522A1 (en) * 2015-03-31 2018-03-08 Prevent Patch, LLC Devices and methods for preventing incisional hernias
US9936940B2 (en) 2013-06-07 2018-04-10 Biomet Sports Medicine, Llc Method and apparatus for coupling soft tissue to bone
US20180132915A1 (en) * 2016-11-11 2018-05-17 Stryker European Holdings I, Llc Implant for bone fixation
US20190000628A1 (en) * 2011-02-28 2019-01-03 DePuy Synthes Products, Inc. Modular tissue scaffolds
US10383624B2 (en) 2008-10-24 2019-08-20 The Foundry, Llc Methods and devices for suture anchor delivery
RU2712297C1 (en) * 2019-03-21 2020-01-28 Федеральное государственное бюджетное учреждение "Российский ордена Трудового Красного Знамени научно-исследовательский институт травматологии и ортопедии имени Р.Р. Вредена" Министерства здравоохранения Российской Федерации (ФГБУ "РНИИТО им. Р.Р. Вредена" Минздрава России) Device for muscle tendons fixation to bones
US10709485B2 (en) 2017-06-30 2020-07-14 Brian K. P. Vickaryous Neutralization plate and related methods
US10722229B2 (en) 2018-07-30 2020-07-28 DePuy Synthes Products, Inc. Suture crimp plate
US10765462B2 (en) 2018-09-11 2020-09-08 DePuy Synthes Products, Inc. Patella bone plate and methods of fixation
US10828074B2 (en) 2015-11-20 2020-11-10 Globus Medical, Inc. Expandalbe intramedullary systems and methods of using the same
US10828075B2 (en) 2015-09-25 2020-11-10 Globus Medical Inc. Bone fixation devices having a locking feature
RU2738161C1 (en) * 2020-01-09 2020-12-09 федеральное государственное бюджетное образовательное учреждение высшего образования "Северный государственный медицинский университет" Министерства здравоохранения Российской Федерации Polypropylene structure for laparoscopic hernioplasty in recurrent inguinal hernias
US10905478B2 (en) 2015-09-04 2021-02-02 DePuy Synthes Products, Inc. Patella bone plate and methods of fixation
US11071570B2 (en) 2018-03-02 2021-07-27 Globus Medical, Inc. Distal tibial plating system
US11096730B2 (en) 2017-09-13 2021-08-24 Globus Medical Inc. Bone stabilization systems
US11129627B2 (en) 2019-10-30 2021-09-28 Globus Medical, Inc. Method and apparatus for inserting a bone plate
US11141172B2 (en) 2018-04-11 2021-10-12 Globus Medical, Inc. Method and apparatus for locking a drill guide in a polyaxial hole
US11197701B2 (en) 2016-08-17 2021-12-14 Globus Medical, Inc. Stabilization systems
US11197704B2 (en) 2016-04-19 2021-12-14 Globus Medical, Inc. Implantable compression screws
US11202663B2 (en) 2019-02-13 2021-12-21 Globus Medical, Inc. Proximal humeral stabilization systems and methods thereof
US11224468B2 (en) 2018-03-02 2022-01-18 Globus Medical, Inc. Distal tibial plating system
US11259853B2 (en) 2015-01-09 2022-03-01 Stryker European Operations Holdings Llc Implant for bone fixation
US11284920B2 (en) 2016-03-02 2022-03-29 Globus Medical Inc. Fixators for bone stabilization and associated systems and methods
US11432857B2 (en) 2016-08-17 2022-09-06 Globus Medical, Inc. Stabilization systems
US11576707B2 (en) 2013-07-11 2023-02-14 Stryker European Operations Holdings Llc Fixation assembly with a flexible elongated member for securing parts of a sternum
US11607254B2 (en) 2017-09-13 2023-03-21 Globus Medical, Inc. Bone stabilization systems
US11723647B2 (en) 2019-12-17 2023-08-15 Globus Medical, Inc. Syndesmosis fixation assembly

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4905680A (en) * 1986-10-27 1990-03-06 Johnson & Johnson Orthopaedics, Inc. Absorbable bone plate
US5002544A (en) * 1987-12-02 1991-03-26 Synthes (U.S.A.) Osteosynthetic pressure plate osteosynthetic compression plate
US5057111A (en) * 1987-11-04 1991-10-15 Park Joon B Non-stress-shielding bone fracture healing device
US5084051A (en) * 1986-11-03 1992-01-28 Toermaelae Pertti Layered surgical biocomposite material
US5676667A (en) * 1995-12-08 1997-10-14 Hausman; Michael Bone fixation apparatus and method

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4905680A (en) * 1986-10-27 1990-03-06 Johnson & Johnson Orthopaedics, Inc. Absorbable bone plate
US5084051A (en) * 1986-11-03 1992-01-28 Toermaelae Pertti Layered surgical biocomposite material
US5057111A (en) * 1987-11-04 1991-10-15 Park Joon B Non-stress-shielding bone fracture healing device
US5002544A (en) * 1987-12-02 1991-03-26 Synthes (U.S.A.) Osteosynthetic pressure plate osteosynthetic compression plate
US5676667A (en) * 1995-12-08 1997-10-14 Hausman; Michael Bone fixation apparatus and method

Cited By (237)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6464706B1 (en) * 1999-06-10 2002-10-15 Thomas F. Winters Tissue fixation device and method
US8535314B2 (en) * 1999-10-30 2013-09-17 Aesculap Ag Surgical connecting element for fixing adjacently arranged bone plates
US20060015106A1 (en) * 1999-10-30 2006-01-19 Karl-Dieter Lerch Surgical connecting element for fixing adjacently arranged bone plates
US20080172097A1 (en) * 1999-10-30 2008-07-17 Karl-Dieter Lerch Surgical connecting element for fixing adjacently arranged bone plates
US6514274B1 (en) * 2000-02-25 2003-02-04 Arthrotek, Inc. Method and apparatus for rotator cuff repair
US7160333B2 (en) 2000-08-04 2007-01-09 Depuy Orthopaedics, Inc. Reinforced small intestinal submucosa
US20070129811A1 (en) * 2000-08-04 2007-06-07 Plouhar Pamela L Reinforced small intestinal submucosa
US7799089B2 (en) 2000-08-04 2010-09-21 Depuy Orthopaedics, Inc. Reinforced small intestinal submucosa
US8366787B2 (en) 2000-08-04 2013-02-05 Depuy Products, Inc. Hybrid biologic-synthetic bioabsorbable scaffolds
EP1322241A4 (en) * 2000-09-20 2005-05-11 Kevin Jon Lawson Cable-anchor system for spinal fixation
EP1322241A1 (en) * 2000-09-20 2003-07-02 Kevin Jon Lawson Cable-anchor system for spinal fixation
WO2002026106A2 (en) * 2000-09-25 2002-04-04 Kinamed, Inc. Suspension plate for attaching the temporalis muscle supporting sutures
WO2002026106A3 (en) * 2000-09-25 2002-08-22 Kinamed Inc Suspension plate for attaching the temporalis muscle supporting sutures
US7001411B1 (en) 2000-09-25 2006-02-21 Dean John C Soft tissue cleat
US6605090B1 (en) 2000-10-25 2003-08-12 Sdgi Holdings, Inc. Non-metallic implant devices and intra-operative methods for assembly and fixation
US20110202091A1 (en) * 2000-10-25 2011-08-18 Warsaw Orthopedic, Inc. Non-metallic implant devices and intra-operative methods for assembly and fixation
US7951177B2 (en) * 2000-10-25 2011-05-31 Warsaw Orthopedic, Inc. Non-metallic implant devices and intra-operative methods for assembly and fixation
US20080167717A9 (en) * 2000-10-25 2008-07-10 Trieu Hai H Non-metallic implant devices and intra-operative methods for assembly and fixation
US20070213828A1 (en) * 2000-10-25 2007-09-13 Trieu Hai H Non-metallic implant devices and intra-operative methods for assembly and fixation
WO2002034159A3 (en) * 2000-10-25 2002-11-28 Sdgi Holdings Inc Non-metallic implant devices and intra-operative methods for assembly and fixation
US8911480B2 (en) * 2000-10-25 2014-12-16 Warsaw Orthopedic, Inc. Non-metallic implant devices and intra-operative methods for assembly and fixation
AU2002220096B2 (en) * 2000-10-25 2005-06-02 Warsaw Orthopedic, Inc. Non-metallic implant devices and intra-operative methods for assembly and fixation
US7172593B2 (en) 2000-10-25 2007-02-06 Sdgi Holdings, Inc. Non-metallic implant devices and intra-operative methods for assembly and fixation
WO2002034159A2 (en) * 2000-10-25 2002-05-02 Sdgi Holdings, Inc. Non-metallic implant devices and intra-operative methods for assembly and fixation
US20040030342A1 (en) * 2000-10-25 2004-02-12 Trieu Hai H. Non-metallic implant devices and intra-operative methods for assembly and fixation
US6692498B1 (en) * 2000-11-27 2004-02-17 Linvatec Corporation Bioabsorbable, osteopromoting fixation plate
US6607548B2 (en) 2001-05-17 2003-08-19 Inion Ltd. Resorbable polymer compositions
US7819918B2 (en) 2001-07-16 2010-10-26 Depuy Products, Inc. Implantable tissue repair device
US7914808B2 (en) 2001-07-16 2011-03-29 Depuy Products, Inc. Hybrid biologic/synthetic porous extracellular matrix scaffolds
US8092529B2 (en) 2001-07-16 2012-01-10 Depuy Products, Inc. Meniscus regeneration device
US8025896B2 (en) 2001-07-16 2011-09-27 Depuy Products, Inc. Porous extracellular matrix scaffold and method
US20030049299A1 (en) * 2001-07-16 2003-03-13 Prasanna Malaviya Porous delivery scaffold and method
US8337537B2 (en) 2001-07-16 2012-12-25 Depuy Products, Inc. Device from naturally occurring biologically derived materials
US20080167716A1 (en) * 2001-07-16 2008-07-10 Schwartz Hebert E Cartilage repair apparatus and method
US7361195B2 (en) 2001-07-16 2008-04-22 Depuy Products, Inc. Cartilage repair apparatus and method
US8012205B2 (en) 2001-07-16 2011-09-06 Depuy Products, Inc. Cartilage repair and regeneration device
US20040210218A1 (en) * 2001-10-15 2004-10-21 Dixon Robert A. Vertebral implant for bone fixation or interbody use
US20060142765A9 (en) * 2001-10-15 2006-06-29 Dixon Robert A Vertebral implant for bone fixation or interbody use
US20060235408A1 (en) * 2001-11-09 2006-10-19 Wang Robert C Apparatus and methods for bone fracture fixation
US20060235407A1 (en) * 2001-11-09 2006-10-19 Wang Robert C Apparatus and methods for bone fracture reduction and fixation
US20110218535A1 (en) * 2001-11-09 2011-09-08 Wang Robert C Apparatus and methods for bone fracture fixation
US8617221B2 (en) 2001-11-09 2013-12-31 Board Of Regents Of The Nevada System Of Higher Education, On Behalf Of The University Of Nevada, Reno Apparatus and methods for bone fracture fixation
US7578835B2 (en) * 2001-11-09 2009-08-25 Board Of Regents Of The Nevada System Of Higher Education Apparatus and methods for bone fracture reduction and fixation
US8197480B2 (en) 2001-12-20 2012-06-12 Depuy Mitek, Inc. Bioabsorbable coatings of surgical devices
EP1321154A3 (en) * 2001-12-20 2004-01-07 Ethicon, Inc. Bioabsorbable coatings of surgical devices
US9737643B2 (en) 2001-12-20 2017-08-22 Depuy Mitek, Llc Bioabsorbable coatings of surgical devices
US7713272B2 (en) 2001-12-20 2010-05-11 Ethicon, Inc. Bioabsorbable coatings of surgical devices
US20100185199A1 (en) * 2001-12-20 2010-07-22 Depuy Mitek, Inc. Bioabsorbable coatings of surgical devices
US8840613B2 (en) 2001-12-20 2014-09-23 Depuy Mitek, Llc Bioabsorbable coatings of surgical devices
US7527649B1 (en) 2002-02-15 2009-05-05 Nuvasive, Inc. Intervertebral implant and related methods
US20050228442A1 (en) * 2002-05-06 2005-10-13 Wheatley Margaret A Tissue joining devices capable of delivery of bioactive agents and methods for use thereof
US20040166169A1 (en) * 2002-07-15 2004-08-26 Prasanna Malaviya Porous extracellular matrix scaffold and method
US6723097B2 (en) * 2002-07-23 2004-04-20 Depuy Spine, Inc. Surgical trial implant
AU2003204910B2 (en) * 2002-07-23 2008-02-21 Depuy Spine, Inc. Surgical trial implant
US7972360B2 (en) 2003-02-05 2011-07-05 Dean John C Method for use in repairs of injured soft tissue
US7303577B1 (en) 2003-02-05 2007-12-04 Dean John C Apparatus and method for use in repairs of injured soft tissue
US20040193165A1 (en) * 2003-03-27 2004-09-30 Hand Innovations, Inc. Anatomical distal radius fracture fixation plate and methods of using the same
US7857838B2 (en) 2003-03-27 2010-12-28 Depuy Products, Inc. Anatomical distal radius fracture fixation plate
US7294130B2 (en) * 2003-03-27 2007-11-13 Depuy Products, Inc. Distal radius fracture fixation plate having K-wire hole structured to fix a K-wire in one dimension relative to the plate
US7282053B2 (en) 2003-03-27 2007-10-16 Depuy Products, Inc. Method of using fracture fixation plate for performing osteotomy
US20050065524A1 (en) * 2003-03-27 2005-03-24 Orbay Jorge L. Anatomical distal radius fracture fixation plate with fixed-angle K-wire holes defining a three-dimensional surface
US8579946B2 (en) 2003-03-27 2013-11-12 Biomet C.V. Anatomical distal radius fracture fixation plate
US7635381B2 (en) 2003-03-27 2009-12-22 Depuy Products, Inc. Anatomical distal radius fracture fixation plate with fixed-angle K-wire holes defining a three-dimensional surface
US20050065523A1 (en) * 2003-03-27 2005-03-24 Orbay Jorge L. Distal radius fracture fixation plate having K-wire hole structured to fix a K-wire in one dimension relative to the plate
US20040193164A1 (en) * 2003-03-27 2004-09-30 Orbay Jorge L. Anatomical distal radius fracture fixation plate and methods of using the same
EP1477124A1 (en) * 2003-05-12 2004-11-17 C.H. Medical Limited Fixation of fractured bones
US8388655B2 (en) 2003-06-11 2013-03-05 Imds Corporation Compact line locks and methods
US9265498B2 (en) 2003-06-11 2016-02-23 Imds Llc Compact line locks and methods
US7255700B2 (en) 2003-06-18 2007-08-14 Biomet Sports Medicine, Inc. Device and method of fastening a graft to a bone
US20040260296A1 (en) * 2003-06-18 2004-12-23 Kaiser Ryan A. Device and method of fastening a graft to a bone
US20050228500A1 (en) * 2003-08-01 2005-10-13 Spinal Kinetics, Inc. Prosthetic intervertebral disc and methods for using same
US7905921B2 (en) * 2003-08-01 2011-03-15 Spinal Kinetics, Inc. Prosthetic intervertebral disc
US9072558B2 (en) 2003-09-17 2015-07-07 Biomet C.V. Distal radius fracture fixation plate with ulnar buttress
US8556945B2 (en) 2003-09-17 2013-10-15 Biomet C.V. Anatomical distal radius fracture fixation plate with ulnar buttress
US7588576B2 (en) * 2003-12-09 2009-09-15 Michael Teague Bone plate holder and screw guide
US20050124990A1 (en) * 2003-12-09 2005-06-09 Michael Teague Bone plate holder and screw guide
WO2005099604A3 (en) * 2004-03-24 2006-06-29 Zwirnmann Ralph Fritz Bone fixation implants
US20050216008A1 (en) * 2004-03-24 2005-09-29 Zwirnmann Ralph F Bone fixation implants
WO2005099604A2 (en) * 2004-03-24 2005-10-27 Zwirnmann, Ralph, Fritz Bone fixation implants
US20050251143A1 (en) * 2004-05-05 2005-11-10 Dillard David G Surgical system and method of use for soft tissue fixation to bone
US8951287B1 (en) 2004-06-02 2015-02-10 Kfx Medical Corporation System and method for attaching soft tissue to bone
US8926663B2 (en) 2004-06-02 2015-01-06 Kfx Medical Corporation System and method for attaching soft tissue to bone
US8529601B2 (en) 2004-06-02 2013-09-10 Kfx Medical Corporation System and method for attaching soft tissue to bone
US9044226B2 (en) 2004-06-02 2015-06-02 Kfx Medical Corporation System and method for attaching soft tissue to bone
US8512378B2 (en) 2004-06-02 2013-08-20 Kfx Medical Corporation Suture anchor
US8109969B1 (en) 2004-06-02 2012-02-07 Kfx Medical Corporation System and method for attaching soft tissue to bone
US8267964B2 (en) 2004-06-02 2012-09-18 Kfx Medical Corporation System and method for attaching soft tissue to bone
US7585311B2 (en) 2004-06-02 2009-09-08 Kfx Medical Corporation System and method for attaching soft tissue to bone
US8100942B1 (en) 2004-06-02 2012-01-24 Kfx Medical Corporation System and method for attaching soft tissue to bone
US10561409B2 (en) 2004-06-02 2020-02-18 Kfx Medical, Llc System and method for attaching soft tissue to bone
US8062334B2 (en) 2004-06-02 2011-11-22 Kfx Medical Corporation Suture anchor
US9655611B2 (en) 2004-06-02 2017-05-23 Kfx Medical, Llc System and method for attaching soft tissue to bone
US9414835B1 (en) 2004-06-02 2016-08-16 Kfx Medical, Llc System and method for attaching soft tissue to bone
US20090318966A1 (en) * 2004-06-02 2009-12-24 Kfx Medical Corporation System and method for attaching soft tissue to bone
US20050273165A1 (en) * 2004-06-04 2005-12-08 Bryan Griffiths Soft tissue spacer
US8945220B2 (en) 2004-06-04 2015-02-03 DePuy Synthes Products, LLC Soft tissue spacer
US20110098760A1 (en) * 2004-06-04 2011-04-28 Bryan Griffiths Soft Tissue Spacer
US7887587B2 (en) 2004-06-04 2011-02-15 Synthes Usa, Llc Soft tissue spacer
US20120046747A1 (en) * 2004-09-07 2012-02-23 Medicinelodge, Inc. Dba Imds Co-Innovation Systems and methods for zipknot acl fixation
US20060128296A1 (en) * 2004-10-29 2006-06-15 Schwan Wade E Intestine processing device and associated method
US9526543B2 (en) 2004-11-10 2016-12-27 Biomet C.V. Modular fracture fixation system
US9913671B2 (en) 2004-11-10 2018-03-13 Biomet C.V. Modular fracture fixation system
US20080200955A1 (en) * 2005-02-22 2008-08-21 Kyon Plate and Screws for Treatment of Bone Fractures
US8968368B2 (en) * 2005-02-22 2015-03-03 Kyon Plate and screws for treatment of bone fractures
US8579944B2 (en) 2005-04-04 2013-11-12 Arthrex, Inc. Bone plate with suture loops
EP1709921A3 (en) * 2005-04-04 2009-04-22 Arthrex, Inc. Bone plate with suture loops
US20060241617A1 (en) * 2005-04-04 2006-10-26 Ashley Holloway Bone plate with suture loops
US20080097490A1 (en) * 2005-04-22 2008-04-24 Helmut Schreiber Method for Marking and Connecting Tissue
US7452364B2 (en) * 2005-04-22 2008-11-18 Helmut Schreiber Surgical marker/connector
US8142453B2 (en) 2005-04-22 2012-03-27 Helmut Schreiber Method for marking and connecting tissue
US20060253153A1 (en) * 2005-04-22 2006-11-09 Helmut Schreiber Surgical marker/connector
US20060247638A1 (en) * 2005-04-29 2006-11-02 Sdgi Holdings, Inc. Composite spinal fixation systems
US20070190230A1 (en) * 2005-04-29 2007-08-16 Trieu Hai H Composite Spinal Fixation Systems
US20070162019A1 (en) * 2005-12-21 2007-07-12 Paul Burns Resorbable anterior cervical plating system with screw retention mechanism
US20070167950A1 (en) * 2005-12-22 2007-07-19 Tauro Joseph C System and method for attaching soft tissue to bone
US10905479B2 (en) 2006-02-24 2021-02-02 DePuy Synthes Products, Inc. Tibial plateau leveling osteotomy plate
US10786290B2 (en) * 2006-02-24 2020-09-29 DePuy Synthes Products, Inc. Tibial plateau leveling osteotomy plate
US11026728B2 (en) 2006-02-24 2021-06-08 DePuy Synthes Products, Inc. Tibial plateau leveling osteotomy plate
US20120265254A1 (en) * 2006-02-24 2012-10-18 Horan Timothy J Tibial plateau leveling osteotomy plate
US20070270853A1 (en) * 2006-04-11 2007-11-22 Ebi, L.P. Contoured bone plate
US20150094810A1 (en) * 2006-04-11 2015-04-02 Biomet Manufacturing, Llc Contoured bone plate
US9750550B2 (en) * 2006-04-11 2017-09-05 Biomet Manufacturing, Llc Contoured bone plate
US8926675B2 (en) * 2006-04-11 2015-01-06 Biomet Manufacturing, Llc Contoured bone plate
US20070270849A1 (en) * 2006-04-21 2007-11-22 Orbay Jorge L Fixation Plate With Multifunctional Holes
US20070288023A1 (en) * 2006-06-12 2007-12-13 Greg Pellegrino Soft tissue repair using tissue augments and bone anchors
US10463409B2 (en) 2006-09-28 2019-11-05 Biomet C.V. Modular fracture fixation system
US7871440B2 (en) 2006-12-11 2011-01-18 Depuy Products, Inc. Unitary surgical device and method
US20080188856A1 (en) * 2007-02-06 2008-08-07 Zimmer Gmbh Central Structures Spreader for the Lumbar Spine
US9107702B2 (en) * 2007-02-06 2015-08-18 Zimmer Gmbh Central structures spreader for the lumbar spine
US20090082816A1 (en) * 2007-09-20 2009-03-26 Graham Matthew R Remodelable orthopaedic spacer and method of using the same
US8267973B2 (en) * 2008-02-27 2012-09-18 Shoulder Options, Inc. Fixable suture anchor plate and method for tendon-to-bone repair
US20090216270A1 (en) * 2008-02-27 2009-08-27 Scott Humphrey Fixable suture anchor plate and method for tendon-to-bone repair
US20090234386A1 (en) * 2008-03-11 2009-09-17 Dean John C Suture Cleat for Soft Tissue Injury Repair
US20100030277A1 (en) * 2008-07-31 2010-02-04 Haidukewych George J Periarticular bone plate with biplanar offset head member
US20100030276A1 (en) * 2008-07-31 2010-02-04 Dave Huebner Periarticular Bone Plate With Biplanar Offset Head Member
US8262707B2 (en) 2008-07-31 2012-09-11 Biomet C.V. Periarticular bone plate with biplanar offset head member
US8257405B2 (en) * 2008-07-31 2012-09-04 Biomet C.V. Periarticular bone plate with biplanar offset head member
US20100049247A1 (en) * 2008-08-25 2010-02-25 Daniel Larkin Suture fixation kit of parts, system, and device
US9060766B2 (en) * 2008-08-25 2015-06-23 Daniel Larkin Suture fixation kit of parts, system, and device
US11272925B2 (en) 2008-10-24 2022-03-15 The Foundry, Llc Methods and devices for suture anchor delivery
US10383624B2 (en) 2008-10-24 2019-08-20 The Foundry, Llc Methods and devices for suture anchor delivery
US20100217392A1 (en) * 2009-02-23 2010-08-26 Bartee Barry K Reinforced ptfe medical barriers
US8556990B2 (en) * 2009-02-23 2013-10-15 Barry K. Bartee Reinforced PTFE medical barriers
US8882812B2 (en) 2009-03-13 2014-11-11 Spinal Simplicity Llc Bone plate assembly with plates that ratchet together
US8574270B2 (en) 2009-03-13 2013-11-05 Spinal Simplicity Llc Bone plate assembly with bone screw retention features
US8262711B2 (en) 2009-03-13 2012-09-11 Spinal Simplicity Llc Dynamic vertebral column plate system
US9095388B2 (en) 2009-03-13 2015-08-04 Spinal Simplicity Llc Bone plate assembly with plates that ratchet together
US20100234895A1 (en) * 2009-03-13 2010-09-16 Harold Hess Dynamic Vertebral Column Plate System
US8814915B2 (en) 2009-03-13 2014-08-26 Spinal Simplicity Llc Dynamic vertebral column plate system
US9463010B2 (en) 2009-05-12 2016-10-11 The Foundry, Llc Methods and devices to treat diseased or injured musculoskeletal tissue
US10588614B2 (en) 2009-05-12 2020-03-17 The Foundry, Llc Methods and devices to treat diseased or injured musculoskeletal tissue
US8545535B2 (en) 2009-05-12 2013-10-01 Foundry Newco Xi, Inc. Suture anchors with one-way cinching mechanisms
US10582919B2 (en) 2009-05-12 2020-03-10 The Foundry, Llc Suture anchors with one-way cinching mechanisms
US9539000B2 (en) 2009-05-12 2017-01-10 The Foundry, Llc Knotless suture anchor and methods of use
US11000267B2 (en) 2009-05-12 2021-05-11 The Foundry, Llc Knotless suture anchor and methods of use
US20110160856A1 (en) * 2009-07-02 2011-06-30 Medicinelodge, Inc. Dba Imds Co-Innovation Systems and Methods for Zipknot ACL Fixation
US20110004252A1 (en) * 2009-07-04 2011-01-06 Jordan Velikov Plate for the treatment of bone fractures
US8834532B2 (en) * 2009-07-07 2014-09-16 Zimmer Gmbh Plate for the treatment of bone fractures
US9011494B2 (en) 2009-09-24 2015-04-21 Warsaw Orthopedic, Inc. Composite vertebral rod system and methods of use
US20110218574A1 (en) * 2010-03-03 2011-09-08 Warsaw Orthopedic, Inc. Dynamic vertebral construct
US9402706B2 (en) * 2010-07-29 2016-08-02 Boston Scientific Scimed, Inc. Bodily implants and methods of adjusting the same
US20120029275A1 (en) * 2010-07-29 2012-02-02 Boston Scientific Scimed, Inc. Bodily implants and methods of adjusting the same
US11793644B2 (en) 2011-02-28 2023-10-24 DePuy Synthes Products, Inc. Modular tissue scaffolds
US10500053B2 (en) * 2011-02-28 2019-12-10 DePuy Synthes Products, Inc. Modular tissue scaffolds
US20190000628A1 (en) * 2011-02-28 2019-01-03 DePuy Synthes Products, Inc. Modular tissue scaffolds
US9827012B2 (en) * 2011-05-10 2017-11-28 Incubeon Cranial plating and bur hole cover system and methods of use
US20160262815A1 (en) * 2011-05-10 2016-09-15 Peter Nakaji Cranial plating and bur hole cover system and methods of use
US9345493B2 (en) * 2011-05-10 2016-05-24 Peter Nakaji Cranial plating and bur hole cover system and methods of use
US20120289964A1 (en) * 2011-05-10 2012-11-15 Peter Nakaji Cranial plating and bur hole cover system and methods of use
US9629707B2 (en) * 2011-09-29 2017-04-25 Smith & Nephew, Inc. Attachment device to attach tissue graft
US20150094763A1 (en) * 2011-09-29 2015-04-02 Smith & Nephew, Inc. Attachment Device to Attach Tissue Graft
WO2013055858A1 (en) 2011-10-11 2013-04-18 Norris Brent Lane Low profile periarticular tension band plating system with soft tissue neutralization cable tunnel/channel
US8906073B2 (en) 2011-10-11 2014-12-09 Brent Lane Norris Low profile periarticular tension band plating system with soft tissue neutralization cable tunnel/channel for use on the greater tuberosity of the humerus
US8906071B2 (en) 2011-10-11 2014-12-09 Brent Lane Norris Low profile periartiular tension band plating system with soft tissue neutralization cable tunnel/channel for use on the olecranon
US8551143B2 (en) 2011-10-11 2013-10-08 Brent Lane Norris Low profile periarticular tension band plating system with soft tissue neutralization cable tunnel/channel
US8906072B2 (en) 2011-10-11 2014-12-09 Brent Lane Norris Low profile periartiular tension band plating system with soft tissue neutralization cable tunnel/channel for use on the greater trochanter
US9445827B2 (en) * 2011-10-25 2016-09-20 Biomet Sports Medicine, Llc Method and apparatus for intraosseous membrane reconstruction
US20130331848A1 (en) * 2011-10-25 2013-12-12 Biomet Sports Medicine, Llc Method And Apparatus For Intraosseous Membrane Reconstruction
US20160066970A1 (en) * 2012-01-05 2016-03-10 The Cleveland Clinic Foundation Bone fixation apparatus
US11197667B2 (en) 2012-01-24 2021-12-14 DePuy Synthes Products, Inc. Compression screw system
US20130190817A1 (en) * 2012-01-24 2013-07-25 Synthes Usa, Llc Compression screw system
US8974504B2 (en) 2012-05-10 2015-03-10 Spinal Simplicity Llc Dynamic bone fracture plates
US8491460B1 (en) * 2012-12-14 2013-07-23 Joseph S. Montgomery, III Method and apparatus for treating vaginal prolapse
KR101277605B1 (en) * 2013-05-08 2013-06-21 ㈜ 이트리온 Plate for fixing bone and method for making the plate
WO2014181928A1 (en) * 2013-05-08 2014-11-13 (주)이트리온 Bone fixing plate and method for manufacturing same
US9936940B2 (en) 2013-06-07 2018-04-10 Biomet Sports Medicine, Llc Method and apparatus for coupling soft tissue to bone
US10842481B2 (en) 2013-06-07 2020-11-24 Biomet Sports Medicine, Llc Method and apparatus for coupling soft tissue to bone
US20140371798A1 (en) * 2013-06-13 2014-12-18 James Platt Channeled bone plate and methods for implanting the same
US9700360B2 (en) * 2013-06-13 2017-07-11 James Platt Channeled bone plate and methods for implanting the same
RU2553191C2 (en) * 2013-06-13 2015-06-10 Муниципальное бюджетное учреждение здравоохранения "Городская клиническая больница N 11" Retainer for stable functional osteosynthesis of patella fractures
US11576707B2 (en) 2013-07-11 2023-02-14 Stryker European Operations Holdings Llc Fixation assembly with a flexible elongated member for securing parts of a sternum
US20180344372A1 (en) * 2014-02-21 2018-12-06 Jeko Metodiev Madjarov Bone Fixation Implants And Methods
US10070904B2 (en) * 2014-02-21 2018-09-11 Jeko Metodiev Madjarov Bone fixation implants
US10952782B2 (en) * 2014-02-21 2021-03-23 Jcor-1, Inc. Bone fixation implants and methods
US10076372B2 (en) * 2014-02-21 2018-09-18 Jeko Metodiev Madjarov Bone fixation implants and methods
US20180344367A1 (en) * 2014-02-21 2018-12-06 Jeko Metodiev Madjarov Bone Fixation Implants
US20150238237A1 (en) * 2014-02-21 2015-08-27 The Charlotte-Mecklenburg Hospital Authority D/B/A Carolinas Healthcare System Bone fixation implants
US20170238981A1 (en) * 2014-02-21 2017-08-24 Jeko Metodiev Madjarov Bone fixation implants and methods
US20170209195A1 (en) * 2014-07-10 2017-07-27 In2Bones Implant and surgical kit for holding bone bodies of a patient in position with respect to one another
US11259853B2 (en) 2015-01-09 2022-03-01 Stryker European Operations Holdings Llc Implant for bone fixation
US10603154B2 (en) * 2015-03-31 2020-03-31 Prevent Patch, LLC Devices and methods for preventing incisional hernias
US20180064522A1 (en) * 2015-03-31 2018-03-08 Prevent Patch, LLC Devices and methods for preventing incisional hernias
US10364319B2 (en) 2015-04-10 2019-07-30 Colorado State University Research Foundation Ring-opening polymerization methods and recyclable biorenewable polyesters
WO2016164911A3 (en) * 2015-04-10 2016-12-15 Colorado State University Research Foundation Ring-opening polymerization methods and recyclable biorenewable polyesters
US11690658B2 (en) 2015-09-04 2023-07-04 DePuy Synthes Products, Inc. Patella bone plate and methods of fixation
US10905478B2 (en) 2015-09-04 2021-02-02 DePuy Synthes Products, Inc. Patella bone plate and methods of fixation
US10828075B2 (en) 2015-09-25 2020-11-10 Globus Medical Inc. Bone fixation devices having a locking feature
CN105167834A (en) * 2015-10-30 2015-12-23 重庆医科大学附属永川医院 Inner fixing steel plate capable of promoting fracture healing for orthopaedics department
US10828074B2 (en) 2015-11-20 2020-11-10 Globus Medical, Inc. Expandalbe intramedullary systems and methods of using the same
US11284920B2 (en) 2016-03-02 2022-03-29 Globus Medical Inc. Fixators for bone stabilization and associated systems and methods
US11197704B2 (en) 2016-04-19 2021-12-14 Globus Medical, Inc. Implantable compression screws
US11432857B2 (en) 2016-08-17 2022-09-06 Globus Medical, Inc. Stabilization systems
US11197701B2 (en) 2016-08-17 2021-12-14 Globus Medical, Inc. Stabilization systems
US10856921B2 (en) * 2016-11-11 2020-12-08 Stryker European Holdings I, Llc Implant for bone fixation
US20180132915A1 (en) * 2016-11-11 2018-05-17 Stryker European Holdings I, Llc Implant for bone fixation
US11596458B2 (en) 2016-11-11 2023-03-07 Stryker European Operations Holdings Llc Implant for bone fixation
US10709485B2 (en) 2017-06-30 2020-07-14 Brian K. P. Vickaryous Neutralization plate and related methods
US11553951B2 (en) 2017-06-30 2023-01-17 Brian K. P. Vickaryous Neutralization plate and related methods
US11607254B2 (en) 2017-09-13 2023-03-21 Globus Medical, Inc. Bone stabilization systems
US11871970B2 (en) 2017-09-13 2024-01-16 Globus Medical, Inc Bone stabilization systems
US11096730B2 (en) 2017-09-13 2021-08-24 Globus Medical Inc. Bone stabilization systems
US11224468B2 (en) 2018-03-02 2022-01-18 Globus Medical, Inc. Distal tibial plating system
US11071570B2 (en) 2018-03-02 2021-07-27 Globus Medical, Inc. Distal tibial plating system
US11771480B2 (en) 2018-03-02 2023-10-03 Globus Medical, Inc. Distal tibial plating system
US11779354B2 (en) 2018-04-11 2023-10-10 Globus Medical Inc. Method and apparatus for locking a drill guide in a polyaxial hole
US11141172B2 (en) 2018-04-11 2021-10-12 Globus Medical, Inc. Method and apparatus for locking a drill guide in a polyaxial hole
US10722229B2 (en) 2018-07-30 2020-07-28 DePuy Synthes Products, Inc. Suture crimp plate
US10765462B2 (en) 2018-09-11 2020-09-08 DePuy Synthes Products, Inc. Patella bone plate and methods of fixation
US11660132B2 (en) 2018-09-11 2023-05-30 DePuy Synthes Products, Inc. Patella bone plate and methods of fixation
US11413078B2 (en) 2018-09-11 2022-08-16 DePuy Synthes Products, Inc. Patella bone plate and methods of fixation
US11202663B2 (en) 2019-02-13 2021-12-21 Globus Medical, Inc. Proximal humeral stabilization systems and methods thereof
US11259848B2 (en) 2019-02-13 2022-03-01 Globus Medical, Inc. Proximal humeral stabilization systems and methods thereof
RU2712297C1 (en) * 2019-03-21 2020-01-28 Федеральное государственное бюджетное учреждение "Российский ордена Трудового Красного Знамени научно-исследовательский институт травматологии и ортопедии имени Р.Р. Вредена" Министерства здравоохранения Российской Федерации (ФГБУ "РНИИТО им. Р.Р. Вредена" Минздрава России) Device for muscle tendons fixation to bones
US11129627B2 (en) 2019-10-30 2021-09-28 Globus Medical, Inc. Method and apparatus for inserting a bone plate
US11826060B2 (en) 2019-10-30 2023-11-28 Globus Medical Inc. Method and apparatus for inserting a bone plate
US11723647B2 (en) 2019-12-17 2023-08-15 Globus Medical, Inc. Syndesmosis fixation assembly
RU2738161C1 (en) * 2020-01-09 2020-12-09 федеральное государственное бюджетное образовательное учреждение высшего образования "Северный государственный медицинский университет" Министерства здравоохранения Российской Федерации Polypropylene structure for laparoscopic hernioplasty in recurrent inguinal hernias

Similar Documents

Publication Publication Date Title
US6093201A (en) Biocompatible absorbable polymer plating system for tissue fixation
US5971987A (en) Biocompatible absorbable polymer fastener and driver for use in surgical procedures
EP0998878B1 (en) Biocompatible absorbable rivets and pins for use in surgical procedures
CA2371670C (en) Scaffold fixation device for use in articular cartilage repair
US6352667B1 (en) Method of making biodegradable polymeric implants
Vert et al. More about the degradation of LA/GA-derived matrices in aqueous media
US6846313B1 (en) One-piece biocompatible absorbable rivet and pin for use in surgical procedures
US5679723A (en) Hard tissue bone cements and substitutes
Pulapura et al. Trends in the development of bioresorbable polymers for medical applications
Vert Biomedical polymers from chiral lactides and functional lactones: Properties and applications
EP0747072B1 (en) Biodegradable moldable surgical material
CN1212865C (en) Utilization of compound capable of biologically absorbing polymer wax and medical equipment
JP2711849B2 (en) Purification method of absorbable polyester
EP1166987B1 (en) Methods of making micropatterned foams
US5705181A (en) Method of making absorbable polymer blends of polylactides, polycaprolactone and polydioxanone
EP1366718A2 (en) Attachment of absorbable tissue scaffolds to fixation devices
EP0949299B1 (en) Two phase thermally deformable biocompatible absorbable polymer matrix for use in medical devices
MXPA97001690A (en) Mixtures containing polyoxamides absorbib
JP2012183318A (en) Fastener device used in surgery
Vert Poly (lactic acid) s
Shalaby Absorbable Polymers with Engineered Biomedical Properties
Vert Understanding of the Bioresorption of PLA/GA Polymers with Respect

Legal Events

Date Code Title Description
AS Assignment

Owner name: ETHICON, INC., NEW JERSEY

Free format text: ASSIGNMENT OF ASSIGNORS INTEREST;ASSIGNORS:COOPER, KEVIN L.;OVERAKER, DAVID W.;REEL/FRAME:009892/0050

Effective date: 19990224

STCF Information on status: patent grant

Free format text: PATENTED CASE

FPAY Fee payment

Year of fee payment: 4

FPAY Fee payment

Year of fee payment: 8

FPAY Fee payment

Year of fee payment: 12