US6096862A - Multimeric antiviral agent - Google Patents
Multimeric antiviral agent Download PDFInfo
- Publication number
- US6096862A US6096862A US08/318,039 US31803994A US6096862A US 6096862 A US6096862 A US 6096862A US 31803994 A US31803994 A US 31803994A US 6096862 A US6096862 A US 6096862A
- Authority
- US
- United States
- Prior art keywords
- icam
- multimeric
- ticam
- antiviral agent
- monomers
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
- C07K14/70503—Immunoglobulin superfamily
- C07K14/70525—ICAM molecules, e.g. CD50, CD54, CD102
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Genetics & Genomics (AREA)
- Zoology (AREA)
- Molecular Biology (AREA)
- Immunology (AREA)
- General Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Biophysics (AREA)
- Biomedical Technology (AREA)
- Medicinal Chemistry (AREA)
- Biochemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Gastroenterology & Hepatology (AREA)
- Wood Science & Technology (AREA)
- General Engineering & Computer Science (AREA)
- Biotechnology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Cell Biology (AREA)
- Toxicology (AREA)
- Plant Pathology (AREA)
- Pharmacology & Pharmacy (AREA)
- Physics & Mathematics (AREA)
- Virology (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Microbiology (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Polysaccharides And Polysaccharide Derivatives (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
Abstract
Description
______________________________________ Abbreviation Definition ______________________________________ ICAM Intercellular adhesion molecule - may be used to denote both full length (transmembrane) and truncated (non- transmembrane) forms of the protein. ICAM-1 Intercellular adhesion molecule-1, also known as ICAM, tmICAM-1; denoting the full length transmembrane protein tmICAM-1 Transmembrane intercellular adhesion molecule-1, also known as human rhino- virus receptor (HRR)-requires e.g., detergent conditions to be solubilized sICAM-1 A naturally occurring soluble ICAM-1 having both the transmembrane and the cytoplasmic domain of ICAM-1 deleted; amino acids 1-442 plus 11 novel amino acids; distinguishable from Staunton, et al. tICAM453 which consists of amino acids 1-453 with the terminal tyrosine replaced with phenylalanine. tICAM Truncated intracellular adhesion molecule, also known as non-transmembrane ICAM. tICAM(453) Truncated form of ICAM - extracellular amino terminal domain of ICAM; having the transmembrane domain and cytoplasmic domain of ICAM-1 deleted; also referred to as sICAM-1 by Marlin, et al. tICAM(185) Truncated form of ICAM - extracellular amino terminal domain of ICAM having the transmembrane domain and cytoplasmic domain of ICAM-1 deleted. ______________________________________
(ggaattcATGGCTCCCAGCAGCCCCCGGCCC) [SEQ ID NO:3] and
PCR 3.1: (ggaattcTCAGGGAGGCGTGGCTTGTGTGTT) [SEQ ID NO:6].
GAGGTGTTCTCAAACAGCTCCAGCCCTTGGGGCCGCAGGTCCAGTTC (ICAM1) [SEQ ID NO:5]
and
CGCTGGCAGGACAAAGGTCTGGAGCTGGTAGGGGGCCGAGGTGTTCT (ICAM3) [SEQ ID NO:6].
______________________________________ Temperature (° C.) Time (mins) ______________________________________ 94 1 55 2 72 1.5 71 4 (final extension) ______________________________________
GGAATTCAAGCTTCTCAGCCTCGCTATGGCTCCCAGCAGCCCCCGGCCC [SEQ ID NO:7]
GGAATTCCTGCAGTCACTCATACCGGGGGGAGAGCACATT [SEQ ID NO:8]
TTCTAGAGGATCCTCAAAAGGTCTGGAGCTGGTAGGGGG [SEQ ID NO:9]
TTCTAGAGGATCCTCACTTCTCATACCGGGGGGAGAGCACATT [SEQ ID NO:10]
TTCTAGAGGATCCTCACTTAAAGGTCTGGAGCTGGTAGGGGGC [SEQ ID NO:11]
TABLE 1 ______________________________________ ICAM % ICAM Pelleted* ______________________________________ tmICAM-1 11.6% tICAM(453) 1.0% tICAM(185) 4.3% ______________________________________ *average of 4 experiments; these numbers cannot be directly converted int relative affinities
TABLE 2 ______________________________________ ICAM IC.sub.50 * ______________________________________ tmICAM 8.0 ± 3.3 nM (N = 3) tICAM(453) 2.8 ± 0.6 μM (N = 3) tICAM(185) 7.9 ± 2.8 μM (N = 3) ______________________________________ *IC.sub.50 is the concentration of soluble ICAM needed to inhibit HRV3 binding by 50%.
TABLE 3 ______________________________________ Binding of .sup.35 S HRV3 to Immobilized ICAM* ICAM tICAM(453) ratio ICAM/tICAM453 ______________________________________ 1.2 ± 1.1 0.52 ± 0.45 2.3 ______________________________________ *Average of 5 experiments. Data is expressed in arbitrary densitometric units of .sup.35 S HRV3 binding/.sup.125 I antiICAM Mab binding.
TABLE 4 ______________________________________ IC50% (μM)* ICAM Assay: A B C ______________________________________ tmICAM-1 0.03 ND ND tICAM(453) >20 0.2 0.2 tICAM(185) >20 ND ND ______________________________________ *IC50% is defined as the concentration of ICAM protein needed to inhibit HRV3 infectivity by 50%.
TABLE 5 ______________________________________ Inhibition of LFA-1/ICAM-1 interaction by soluble ICAM tICAM(453) (μg/ml) % control cell binding* ______________________________________ -- 100 100 96 300 93 600 75 ______________________________________ *Binding to ICAM1-coated microtiter plates; 10 μg/ml antiLFA-1 or antiICAM-1 MAb inhibited binding to >1%.
__________________________________________________________________________ # SEQUENCE LISTING - - - - (1) GENERAL INFORMATION: - - (iii) NUMBER OF SEQUENCES: 11 - - - - (2) INFORMATION FOR SEQ ID NO:1: - - (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 505 (B) TYPE: amino acids (D) TOPOLOGY: linear - - (ii) MOLECULE TYPE: protein - - (iii) HYPOTHETICAL: no - - (ix) FEATURE: (A) NAME/KEY: ICAM-1 pr - #otein - - (x) PUBLICATION INFORMATION: (A) AUTHORS: Staunton, - #D.E., Marlin, S.D., Stratowa, C., Dustin, M - #.L., and Springer, T.A. (B) TITLE: Primary Stru - #cture of ICAM-1 Demonstrates Interaction - #between Members of the Immunoglobulin and Integrin - #Supergene Families (C) JOURNAL: Cell (D) VOLUME: 52 (F) PAGES: 925-933 (G) DATE: March 25, - #1988 - - (xi) SEQUENCE DESCRIPTION: SEQ ID NO: - #1: - - Gln Thr Ser Val Ser Pro Ser Lys Val Ile Le - #u Pro Arg Gly Gly 5 - # 10 - # 15 - - Ser Val Leu Val Thr Cys Ser Thr Ser Cys As - #p Gln Pro Lys Leu 20 - # 25 - # 30 - - Leu Gly Ile Glu Thr Pro Leu Pro Lys Lys Gl - #u Leu Leu Leu Pro 35 - # 40 - # 45 - - Gly Asn Asn Arg Lys Val Tyr Glu Leu Ser As - #n Val Gln Glu Asp 50 - # 55 - # 60 - - Ser Gln Pro Met Cys Tyr Ser Asn Cys Pro As - #p Gly Gln Ser Thr 65 - # 70 - # 75 - - Ala Lys Thr Phe Leu Thr Val Tyr Trp Thr Pr - #o Glu Arg Val Glu 80 - # 85 - # 90 - - Leu Ala Pro Leu Pro Ser Trp Gln Pro Val Gl - #y Lys Asn Leu Thr 95 - # 100 - # 105 - - Leu Arg Cys Gln Val Glu Gly Gly Ala Pro Ar - #g Ala Asn Leu Thr 110 - # 115 - # 120 - - Val Val Leu Leu Arg Gly Glu Lys Glu Leu Ly - #s Arg Glu Pro Ala 125 - # 130 - # 135 - - Val Gly Glu Pro Ala Glu Val Thr Thr Thr Va - #l Leu Val Arg Arg 140 - # 145 - # 150 - - Asp His His Gly Ala Asn Phe Ser Cys Arg Th - #r Glu Leu Asp Leu 155 - # 160 - # 165 - - Arg Pro Gln Gly Leu Glu Leu Phe Glu Asn Th - #r Ser Ala Pro Tyr 170 - # 175 - # 180 - - Gln Leu Gln Thr Phe Val Leu Pro Ala Thr Pr - #o Pro Gln Leu Val 185 - # 190 - # 195 - - Ser Pro Arg Val Leu Glu Val Asp Thr Gln Gl - #y Thr Val Val Cys 200 - # 205 - # 210 - - Ser Leu Asp Gly Leu Phe Pro Val Ser Glu Al - #a Gln Val His Leu 215 - # 220 - # 225 - - Ala Leu Gly Asp Gln Arg Leu Asn Pro Thr Va - #l Thr Tyr Gly Asn 230 - # 235 - # 240 - - Asp Ser Phe Ser Ala Lys Ala Ser Val Ser Va - #l Thr Ala Glu Asp 245 - # 250 - # 255 - - Glu Gly Thr Gln Arg Leu Thr Cys Ala Val Il - #e Leu Gly Asn Gln 260 - # 265 - # 270 - - Ser Gln Glu Thr Leu Gln Thr Val Thr Ile Ty - #r Ser Phe Pro Ala 275 - # 280 - # 285 - - Pro Asn Val Ile Leu Thr Lys Pro Glu Val Se - #r Glu Gly Thr Glu 290 - # 295 - # 300 - - Val Thr Val Lys Cys Glu Ala His Pro Arg Al - #a Lys Val Thr Leu 305 - # 310 - # 315 - - Asn Gly Val Pro Ala Gln Pro Leu Gly Pro Ar - #g Ala Gln Leu Leu 320 - # 325 - # 330 - - Leu Lys Ala Thr Pro Glu Asp Asn Gly Arg Se - #r Phe Ser Cys Ser 335 - # 340 - # 345 - - Ala Thr Leu Glu Val Ala Gly Gln Leu Ile Hi - #s Lys Asn Gln Thr 350 - # 355 - # 360 - - Arg Glu Leu Arg Val Leu Tyr Gly Pro Arg Le - #u Asp Glu Arg Asp 365 - # 370 - # 375 - - Cys Pro Gly Asn Trp Thr Trp Pro Glu Asn Se - #r Gln Gln Thr Pro 380 - # 385 - # 390 - - Met Cys Gln Ala Trp Gly Asn Pro Leu Pro Gl - #u Leu Lys Cys Leu 395 - # 400 - # 405 - - Lys Asp Gly Thr Phe Pro Leu Pro Ile Gly Gl - #u Ser Val Thr Val 410 - # 415 - # 420 - - Thr Arg Asp Leu Glu Gly Thr Tyr Leu Cys Ar - #g Ala Arg Ser Thr 425 - # 430 - # 435 - - Gln Gly Glu Val Thr Arg Glu Val Thr Val As - #n Val Leu Ser Pro 440 - # 445 - # 450 - - Arg Tyr Glu Ile Val Ile Ile Thr Val Val Al - #a Ala Ala Val Ile 455 - # 460 - # 465 - - Met Gly Thr Ala Gly Leu Ser Thr Tyr Leu Ty - #r Asn Arg Gln Arg 470 - # 475 - # 480 - - Lys Ile Lys Lys Tyr Arg Leu Gln Gln Ala Gl - #n Lys Gly Thr Pro 485 - # 490 - # 495 - - Met Lys Pro Asn Thr Gln Ala Thr Pro Pro 500 - # 505 - - - - (2) INFORMATION FOR SEQ ID NO:2: - - (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 1656 (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear - - (ii) MOLECULE TYPE: other nucleic acid - - (iii) HYPOTHETICAL: no - - (iv) ANTI-SENSE: no - - (ix) FEATURE: (A) NAME/KEY: ICAM-1 co - #ding sequence - - (x) PUBLICATION INFORMATION: (A) AUTHORS: Staunton, - #D.E., Marlin, S.D., Stratowa, C., Dustin, M - #.L., and Springer, T.A. (B) TITLE: Primary Stru - #cture of ICAM-1 Demonstrates Interaction - #between Members of the Immunoglobulin and Integrin - #Supergene Families (C) JOURNAL: Cell (D) VOLUME: 52 (F) PAGES: 925-933 (G) DATE: March 25, - #1988 (K) RELEVANT RESIDUES I - #N SEQ ID NO:2: From 58 to 1653 - - (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2: - - gcgccccagt cgacgctgag ctcctctgct actcagagtt gcaacctcag cc - #tcgctatg 60 - - gctcccagca gcccccggcc cgcgctgccc gcactcctgg tcctgctggg gg - #ctctgtta 120 - - ccaggacctg gcaatgcc cag aca tct gtg tcc ccc tca - #aaa gtc atc ctg 171 - # Gln Thr Ser Val Ser Pro Ser Lys Val - #Ile Leu - # 1 - #5 - # 10 - - ccc cgg gga ggc tcc gtg ctg gtg aca tgc ag - #c acc tcc tgt gac cag 219 Pro Arg Gly Gly Ser Val Leu Val Thr Cys Se - #r Thr Ser Cys Asp Gln 15 - # 20 - # 25 - - ccc aag ttg ttg ggc ata gag acc ccg ttg cc - #t aaa aag gag ttg ctc 267 Pro Lys Leu Leu Gly Ile Glu Thr Pro Leu Pr - #o Lys Lys Glu Leu Leu 30 - # 35 - # 40 - - ctg cct ggg aac aac cgg aag gtg tat gaa ct - #g agc aat gtg caa gaa 315 Leu Pro Gly Asn Asn Arg Lys Val Tyr Glu Le - #u Ser Asn Val Gln Glu 45 - # 50 - # 55 - - gat agc caa cca atg tgc tat tca aac tgc cc - #t gat ggg cag tca aca 363 Asp Ser Gln Pro Met Cys Tyr Ser Asn Cys Pr - #o Asp Gly Gln Ser Thr 60 - # 65 - # 70 - # 75 - - gct aaa acc ttc ctc acc gtg tac tgg act cc - #a gaa cgg gtg gaa ctg 411 Ala Lys Thr Phe Leu Thr Val Tyr Trp Thr Pr - #o Glu Arg Val Glu Leu 80 - # 85 - # 90 - - gca ccc ctc ccc tct tgg cag cca gtg ggc aa - #g aac ctt acc cta cgc 459 Ala Pro Leu Pro Ser Trp Gln Pro Val Gly Ly - #s Asn Leu Thr Leu Arg 95 - # 100 - # 105 - - tgc cag gtg gag ggt ggg gca ccc cgg gcc aa - #c ctc acc gtg gtg ctg 507 Cys Gln Val Glu Gly Gly Ala Pro Arg Ala As - #n Leu Thr Val Val Leu 110 - # 115 - # 120 - - ctc cgt ggg gag aag gag ctg aaa cgg gag cc - #a gct gtg ggg gag ccc 555 Leu Arg Gly Glu Lys Glu Leu Lys Arg Glu Pr - #o Ala Val Gly Glu Pro 125 - # 130 - # 135 - - gct gag gtc acg acc acg gtg ctg gtg agg ag - #a gat cac cat gga gcc 603 Ala Glu Val Thr Thr Thr Val Leu Val Arg Ar - #g Asp His His Gly Ala 140 1 - #45 1 - #50 1 - #55 - - aat ttc tcg tgc cgc act gaa ctg gac ctg cg - #g ccc caa ggg ctg gag 651 Asn Phe Ser Cys Arg Thr Glu Leu Asp Leu Ar - #g Pro Gln Gly Leu Glu 160 - # 165 - # 170 - - ctg ttt gag aac acc tcg gcg ccc tac cag ct - #c cag acc ttt gtc ctg 699 Leu Phe Glu Asn Thr Ser Ala Pro Tyr Gln Le - #u Gln Thr Phe Val Leu 175 - # 180 - # 185 - - cca gcg act ccc cca caa ctt gtc agc ccc cg - #g gtc cta gag gtg gac 747 Pro Ala Thr Pro Pro Gln Leu Val Ser Pro Ar - #g Val Leu Glu Val Asp 190 - # 195 - # 200 - - acg cag ggg acc gtg gtc tgt tcc ctg gac gg - #g ctg ttc cca gtc tcg 795 Thr Gln Gly Thr Val Val Cys Ser Leu Asp Gl - #y Leu Phe Pro Val Ser 205 - # 210 - # 215 - - gag gcc cag gtc cac ctg gca ctg ggg gac ca - #g agg ttg aac ccc aca 843 Glu Ala Gln Val His Leu Ala Leu Gly Asp Gl - #n Arg Leu Asn Pro Thr 220 2 - #25 2 - #30 2 - #35 - - gtc acc tat ggc aac gac tcc ttc tcg gcc aa - #g gcc tca gtc agt gtg 891 Val Thr Tyr Gly Asn Asp Ser Phe Ser Ala Ly - #s Ala Ser Val Ser Val 240 - # 245 - # 250 - - acc gca gag gac gag ggc acc cag cgg ctg ac - #g tgt gca gta ata ctg 939 Thr Ala Glu Asp Glu Gly Thr Gln Arg Leu Th - #r Cys Ala Val Ile Leu 255 - # 260 - # 265 - - ggg aac cag agc cag gag aca ctg cag aca gt - #g acc atc tac agc ttt 987 Gly Asn Gln Ser Gln Glu Thr Leu Gln Thr Va - #l Thr Ile Tyr Ser Phe 270 - # 275 - # 280 - - ccg gcg ccc aac gtg att ctg acg aag cca ga - #g gtc tca gaa ggg acc 1035 Pro Ala Pro Asn Val Ile Leu Thr Lys Pro Gl - #u Val Ser Glu Gly Thr 285 - # 290 - # 295 - - gag gtg aca gtg aag tgt gag gcc cac cct ag - #a gcc aag gtg acg ctg 1083 Glu Val Thr Val Lys Cys Glu Ala His Pro Ar - #g Ala Lys Val Thr Leu 300 3 - #05 3 - #10 3 - #15 - - aat ggg gtt cca gcc cag cca ctg ggc ccg ag - #g gcc cag ctc ctg ctg 1131 Asn Gly Val Pro Ala Gln Pro Leu Gly Pro Ar - #g Ala Gln Leu Leu Leu 320 - # 325 - # 330 - - aag gcc acc cca gag gac aac ggg cgc agc tt - #c tcc tgc tct gca acc 1179 Lys Ala Thr Pro Glu Asp Asn Gly Arg Ser Ph - #e Ser Cys Ser Ala Thr 335 - # 340 - # 345 - - ctg gag gtg gcc ggc cag ctt ata cac aag aa - #c cag acc cgg gag ctt 1227 Leu Glu Val Ala Gly Gln Leu Ile His Lys As - #n Gln Thr Arg Glu Leu 350 - # 355 - # 360 - - cgt gtc ctg tat ggc ccc cga ctg gac gag ag - #g gat tgt ccg gga aac 1275 Arg Val Leu Tyr Gly Pro Arg Leu Asp Glu Ar - #g Asp Cys Pro Gly Asn 365 - # 370 - # 375 - - tgg acg tgg cca gaa aat tcc cag cag act cc - #a atg tgc cag gct tgg 1323 Trp Thr Trp Pro Glu Asn Ser Gln Gln Thr Pr - #o Met Cys Gln Ala Trp 380 3 - #85 3 - #90 3 - #95 - - ggg aac cca ttg ccc gag ctc aag tgt cta aa - #g gat ggc act ttc cca 1371 Gly Asn Pro Leu Pro Glu Leu Lys Cys Leu Ly - #s Asp Gly Thr Phe Pro 400 - # 405 - # 410 - - ctg ccc atc ggg gaa tca gtg act gtc act cg - #a gat ctt gag ggc acc 1419 Leu Pro Ile Gly Glu Ser Val Thr Val Thr Ar - #g Asp Leu Glu Gly Thr 415 - # 420 - # 425 - - tac ctc tgt cgg gcc agg agc act caa ggg ga - #g gtc acc cgc gag gtg 1467 Tyr Leu Cys Arg Ala Arg Ser Thr Gln Gly Gl - #u Val Thr Arg Glu Val 430 - # 435 - # 440 - - acc gtg aat gtg ctc tcc ccc cgg tat gag at - #t gtc atc atc act gtg 1515 Thr Val Asn Val Leu Ser Pro Arg Tyr Glu Il - #e Val Ile Ile Thr Val 445 - # 450 - # 455 - - gta gca gcc gca gtc ata atg ggc act gca gg - #c ctc agc acg tac ctc 1563 Val Ala Ala Ala Val Ile Met Gly Thr Ala Gl - #y Leu Ser Thr Tyr Leu 460 4 - #65 4 - #70 4 - #75 - - tat aac cgc cag cgg aag atc aag aaa tac ag - #a cta caa cag gcc caa 1611 Tyr Asn Arg Gln Arg Lys Ile Lys Lys Tyr Ar - #g Leu Gln Gln Ala Gln 480 - # 485 - # 490 - - aaa ggg acc ccc atg aaa ccg aac aca caa gc - #c acg cct ccc - #1653 Lys Gly Thr Pro Met Lys Pro Asn Thr Gln Al - #a Thr Pro Pro 495 - # 500 - # 505 - - tga - # - # - # 1656 - - - - (2) INFORMATION FOR SEQ ID NO:3: - - (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 31 (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear - - (ii) MOLECULE TYPE: other nucleic acid - - (iii) HYPOTHETICAL: no - - (iv) ANTI-SENSE: no - - (ix) FEATURE: (A) NAME/KEY: PCR 5.1 - #(5' PCR primer) (B) LOCATION: 5' end - # of ICAM-1 coding sequence (D) OTHER INFORMATION: - #bp 1 = G; bp 2-7 = EcoRI site; bp - #8-31 = 24 bases coding for the first eig - #ht amino acid residues of hICAM-1 - - (x) PUBLICATION INFORMATION: (A) AUTHORS: Greve, J.M - #., G. Davis, A.M. Meyer, C.P. Fort - #e, S.C. Yost, C.W. Marlor, M.E. Kamarck, - #and A. McClelland (B) TITLE: The Major - #Human Rhinovirus Receptor is ICAM-1 (C) JOURNAL: Cell (D) VOLUME: 56 (F) PAGES: 839-847 (G) DATE: March 10, - #1989 (K) RELEVANT RESIDUES I - #N SEQ ID NO:3: From 1 to 31 - - (xi) SEQUENCE DESCRIPTION: SEQ ID NO:3: - - GGAATTC ATG GCT CCC AGC AGC CCC CGG CCC - # - # 31 Met Ala Pro Ser Ser Pro - #Arg Pro - # 5 - - - - (2) INFORMATION FOR SEQ ID NO:4: - - (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 31 bp (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear - - (ii) MOLECULE TYPE: other nucleic acid - - (iii) HYPOTHETICAL: no - - (iv) ANTI-SENSE: yes - - (ix) FEATURE: (A) NAME/KEY: PCR 3.1 - #(3' PCR primer) (B) LOCATION: 3' end - # of ICAM-1 coding sequence (D) OTHER INFORMATION: - #bp 1 = G; bp 2-7 = EcoRI site; bp - #8-31 = 24 bases complementary to nucleic a - #cid sequence coding for last 8 amino aci - #d residues of hICAM-1 - - (x) PUBLICATION INFORMATION: (A) AUTHORS: Greve, J.M - #., G. Davis, A.M. Meyer, C.P. Fort - #e, S.C. Yost, C.W. Marlor, M.E. Kamarck, - #and A. McClelland (B) TITLE: The Major - #Human Rhinovirus Receptor is ICAM-1 (C) JOURNAL: Cell (D) VOLUME: 56 (F) PAGES: 839-847 (G) DATE: March 10, - #1989 (K) RELEVANT RESIDUES I - #N SEQ ID NO:4: From 1 to 31 - - (xi) SEQUENCE DESCRIPTION: SEQ ID NO:4: - - GGAATTCTCA GGGAGGCGTG GCTTGTGTGT T - # - # 31 - - - - (2) INFORMATION FOR SEQ ID NO:5: - - (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 47 bp (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear - - (ii) MOLECULE TYPE: other nucleic acid - - (iii) HYPOTHETICAL: no - - (iv) ANTI-SENSE: yes - - (ix) FEATURE: (A) NAME/KEY: ICAM1 pro - #be (D) OTHER INFORMATION: - #complementary to nucleotides - #565 to 611 of ICAM-1 - - (x) PUBLICATION INFORMATION: (A) AUTHORS: Greve, J.M - #., G. Davis, A.M. Meyer, C.P. Fort - #e, S.C. Yost, C.W. Marlor, M.E. Kamarck, - #and A. McClelland (B) TITLE: The Major - #Human Rhinovirus Receptor is ICAM-1 (C) JOURNAL: Cell (D) VOLUME: 56 (F) PAGES: 839-847 (G) DATE: March 10, - #1989 (K) RELEVANT RESIDUES I - #N SEQ ID NO:5: From 1 to 47 - - (xi) SEQUENCE DESCRIPTION: SEQ ID NO:5: - - GAGGTGTTCT CAAACAGCTC CAGCCCTTGG GGCCGCAGGT CCAGTTC - # 47 - - - - (2) INFORMATION FOR SEQ ID NO:6: - - (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 47 bp (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear - - (ii) MOLECULE TYPE: other nucleic acid - - (iii) HYPOTHETICAL: no - - (iv) ANTI-SENSE: yes - - (ix) FEATURE: (A) NAME/KEY: ICAM3 pro - #be (B) LOCATION: complementar - #y to nucleotides 659 to 705 - #of human ICAM-1 - - (xi) SEQUENCE DESCRIPTION: SEQ ID NO:6: - - CGCTGGCAGG ACAAAGGTCT GGAGCTGGTA GGGGGCCGAG GTGTTCT - # 47 - - - - (2) INFORMATION FOR SEQ ID NO:7: - - (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 49 bp (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear - - (ii) MOLECULE TYPE: other nucleic acid - - (iii) HYPOTHETICAL: no - - (iv) ANTI-SENSE: no - - (ix) FEATURE: (A) NAME/KEY: PCR 5.5 (D) OTHER INFORMATION: - #bp 1 = G; bp 2-7 = EcoRI site; bp - #8-13 = HindIII site; bp 14-25 = hICAM-1 5 - #' untranslated region; bp 26-49 = sequence - #coding for first 8 amino acid residues - #of hICAM-1 - - (x) PUBLICATION INFORMATION: (A) AUTHORS: Greve, J.M - #., C.P. Forte, C.W. Marlor, A - #.M. Meyer, H. Hoover-Litty, D. Wunderlich, - #and A. McClelland (B) TITLE: "Mechanisms - #of Receptor-mediated Rhinovirus - #Neutralization Defined by Two Soluble F - #orms of ICAM-1" (C) JOURNAL: Journal of - # Virology (D) VOLUME: 65 (E) ISSUE: 11 (F) PAGES: 6015-6023 (G) DATE: 1991 (K) RELEVANT RESIDUES I - #N SEQ ID NO:7: From 1 to 49 - - (xi) SEQUENCE DESCRIPTION: SEQ ID NO:7: - - GGAATTCAAG CTTCTCAGCC TCGCT ATG GCT CCC AGC AGC - #CCC CGG CCC 49 - # Met Ala Pro Ser Ser - # Pro Arg Pro - # - # 5 - - - - (2) INFORMATION FOR SEQ ID NO:8: - - (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 40 bp (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear - - (ii) MOLECULE TYPE: other nucleic acid - - (iii) HYPOTHETICAL: no - - (iv) ANTI-SENSE: yes - - (ix) FEATURE: (A) NAME/KEY: PCR 3.3 (D) OTHER INFORMATION: - #bp 1 = G; bp 2-7 = EcoRI site; bp - #8-13 = PstI site; bp 14-16 = stop codon; bp - # 17-40 = complementary to nucleotide - #sequence coding for residues 453-446 of hICAM-1 - - (x) PUBLICATION INFORMATION: (A) AUTHORS: Greve, J.M - #., C.P. Forte, C.W. Marlor, A - #.M. Meyer, H. Hoover-Litty, D. Wunderlich, - #and A. McClelland (B) TITLE: Mechanisms o - #f Receptor-mediated Rhinovirus - #Neutralization Defined by Two Soluble F - #orms of ICAM-1 (C) JOURNAL: Journal of - # Virology (D) VOLUME: 65 (E) ISSUE: 11 (F) PAGES: 6015-6023 (G) DATE: 1991 (K) RELEVANT RESIDUES I - #N SEQ ID NO:8: From 1 to 40 - - (xi) SEQUENCE DESCRIPTION: SEQ ID NO:8: - - GGAATTCCTG CAGTCACTCA TACCGGGGGG AGAGCACATT - # - # 40 - - - - (2) INFORMATION FOR SEQ ID NO:9: - - (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 39 bp (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear - - (ii) MOLECULE TYPE: other nucleic acid - - (iii) HYPOTHETICAL: no - - (iv) ANTI-SENSE: yes - - (ix) FEATURE: (A) NAME/KEY: PCR 3.10 (D) OTHER INFORMATION: - #bp 1 = T; bp 2-7 = Xba site; bp - #8-13 = Bam site; bp 14-16 = stop codon; bp - # 17-39 = sequence complementary to nucleotides - #693-671 which code for amino acid resi - #dues 185-178 of hICAM-1 - - (x) PUBLICATION INFORMATION: (A) AUTHORS: Greve, J.M - #., C.P. Forte, C.W. Marlor, A - #.M. Meyer, H. Hoover-Litty, D. Wunderlich, - #and A. McClelland (B) TITLE: Mechanisms o - #f Receptor-mediated Rhinovirus - #Neutralization Defined by Two Soluble F - #orms of ICAM-1 (C) JOURNAL: Journal of - # Virology (D) VOLUME: 65 (E) ISSUE: 11 (F) PAGES: 6015-6023 (G) DATE: 1991 (K) RELEVANT RESIDUES I - #N SEQ ID NO:9: From 1 to 39 - - (xi) SEQUENCE DESCRIPTION: SEQ ID NO:9: - - TTCTAGAGGA TCCTCAAAAG GTCTGGAGCT GGTAGGGGG - # - # 39 - - - - (2) INFORMATION FOR SEQ ID NO:10: - - (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 43 bp (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear - - (ii) MOLECULE TYPE: other nucleic acid - - (iii) HYPOTHETICAL: no - - (iv) ANTI-SENSE: yes - - (ix) FEATURE: (A) NAME/KEY: PCR 3.19 (D) OTHER INFORMATION: - #bp 1 = T; bp 2-7 = Xba site; bp - #8-13 = Bam site; bp 14-16 = stop codon; bp - # 17-19 = lysine codon; bp 20 - 43 = sequence - #complementary to nucleotides coding for amino - # acid residues 453-446 of hICAM-1 - - (xi) SEQUENCE DESCRIPTION: SEQ ID NO:10: - - TTCTAGAGGA TCCTCACTTC TCATACCGGG GGGAGAGCAC ATT - # - # 43 - - - - (2) INFORMATION FOR SEQ ID NO:11: - - (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 43 bp (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear - - (ii) MOLECULE TYPE: other nucleic acid - - (iii) HYPOTHETICAL: no - - (iv) ANTI-SENSE: yes - - (ix) FEATURE: (A) NAME/KEY: PCR 3.20 (D) OTHER INFORMATION: - #bp 1 = T; bp 2-7 = Xba site; bp - #8-13 = Bam site; bp 14-16 = stop codon; bp - # 17-19 = lysine codon; bp 20 - 43 = sequence - #complementary to nucleotides coding for amino - # acid residues 185-178 of hICAM-1 - - (xi) SEQUENCE DESCRIPTION: SEQ ID NO:11: - - TTCTAGAGGA TCCTCACTTA AAGGTCTGGA GCTGGTAGGG GGC - # - # 43 __________________________________________________________________________
Claims (10)
Priority Applications (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US08/318,039 US6096862A (en) | 1990-07-20 | 1994-10-04 | Multimeric antiviral agent |
US08/469,581 US5686581A (en) | 1990-07-20 | 1995-06-05 | Multimeric form of human rhinovirus receptor protein |
US08/469,588 US5674982A (en) | 1990-07-20 | 1995-06-05 | Multimeric form of human rhinovirus receptor protein |
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US55623890A | 1990-07-20 | 1990-07-20 | |
US97758992A | 1992-11-17 | 1992-11-17 | |
US15907693A | 1993-11-29 | 1993-11-29 | |
US08/318,039 US6096862A (en) | 1990-07-20 | 1994-10-04 | Multimeric antiviral agent |
Related Parent Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
US15907693A Continuation | 1990-07-20 | 1993-11-29 |
Related Child Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
US08/469,588 Continuation US5674982A (en) | 1990-07-20 | 1995-06-05 | Multimeric form of human rhinovirus receptor protein |
US08/469,581 Continuation US5686581A (en) | 1990-07-20 | 1995-06-05 | Multimeric form of human rhinovirus receptor protein |
Publications (1)
Publication Number | Publication Date |
---|---|
US6096862A true US6096862A (en) | 2000-08-01 |
Family
ID=24220489
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
US08/318,039 Expired - Lifetime US6096862A (en) | 1990-07-20 | 1994-10-04 | Multimeric antiviral agent |
Country Status (14)
Country | Link |
---|---|
US (1) | US6096862A (en) |
EP (2) | EP0987329A3 (en) |
JP (1) | JP3091527B2 (en) |
KR (1) | KR100208847B1 (en) |
AT (1) | ATE184049T1 (en) |
DE (1) | DE69131564T2 (en) |
DK (1) | DK0468257T3 (en) |
ES (1) | ES2134762T3 (en) |
FI (1) | FI105687B (en) |
GR (1) | GR3031768T3 (en) |
IE (1) | IE912552A1 (en) |
IL (1) | IL98866A0 (en) |
PT (1) | PT98394B (en) |
ZA (1) | ZA915678B (en) |
Cited By (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6326004B1 (en) | 1988-09-01 | 2001-12-04 | Bayer Corporation | Antiviral methods using fragments of human rhinovirus receptor (ICAM-1) |
US6867203B2 (en) | 1998-12-29 | 2005-03-15 | Abbott Laboratories | Cell adhesion-inhibiting antiinflammatory and immune-suppressive compounds |
US7132395B1 (en) | 1988-09-01 | 2006-11-07 | Bayer Pharmaceuticals Corporation | Antiviral methods using human rhinovirus receptor (ICAM-1) |
US20080131454A1 (en) * | 2006-12-05 | 2008-06-05 | Marinomed Biotechnologie Gmbh | Methods and Compositions for the Treatment of Rhinovirus Infections with Carrageenan |
US20100160254A1 (en) * | 2006-04-04 | 2010-06-24 | Marinomed Biotechnologie Gmbh | Cellulose Sulfate for the Treatment of Rhinovirus Infection |
Families Citing this family (24)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6051231A (en) * | 1988-09-01 | 2000-04-18 | Bayer Corporation | Antiviral methods and prepations |
US6143298A (en) * | 1988-09-01 | 2000-11-07 | Bayer Corporation | Soluble truncated forms of ICAM-1 |
ATE184049T1 (en) * | 1990-07-20 | 1999-09-15 | Bayer Ag | MULTIPLE FORMS OF HUMAN RHINOVIRUS RECEPTOR PROTEIN |
US6107461A (en) * | 1990-07-20 | 2000-08-22 | Bayer Corporation | Multimeric forms of human rhinovirus receptor and fragments thereof, and method of use |
US6130202A (en) * | 1990-07-20 | 2000-10-10 | Bayer Corporation | Antiviral methods |
US5891841A (en) * | 1991-06-11 | 1999-04-06 | The Center For Blood Research, Inc. | Methods of using intercellular adhesion molecule-3 (ICAM-3), antibodies thereto, and soluble fragments thereof |
US6818743B1 (en) | 1992-01-27 | 2004-11-16 | Icos Corporation | I-CAM related protein |
US6100383A (en) * | 1992-01-27 | 2000-08-08 | Icos Corporation | Fusion proteins comprising ICAM-R polypeptides and immunoglobulin constant regions |
US5700658A (en) * | 1992-01-27 | 1997-12-23 | Icos Corporation | ICAM-4 materials and methods |
CA2107097A1 (en) * | 1992-01-27 | 1993-07-28 | Michael W. Gallatin | Icam-related protein |
US5852170A (en) * | 1992-01-27 | 1998-12-22 | Icos Corporation | ICAM-4 materials and methods |
US5532127A (en) * | 1992-01-27 | 1996-07-02 | Icos Corporation | Assay for 1-CAM related protein expression |
US5753502A (en) * | 1993-08-05 | 1998-05-19 | Icos Corporation | Neuron-specific ICAM-4 promoter |
US5773293A (en) * | 1992-01-27 | 1998-06-30 | Icos Corporation | Anti-ICAM-4 antibodies and hybridomas |
US5773218A (en) * | 1992-01-27 | 1998-06-30 | Icos Corporation | Method to identify compounds which modulate ICAM-related protein interactions |
US5525487A (en) * | 1992-01-27 | 1996-06-11 | Icos Corporation | DNA encoding I-CAM related protein |
US5989843A (en) * | 1992-01-27 | 1999-11-23 | Icos Corporation | Methods for identifying modulators of protein kinase C phosphorylation of ICAM-related protein |
US5702917A (en) * | 1992-01-27 | 1997-12-30 | Icos Corporation | Polynucleotides encoding human ICAM-4 |
US5837822A (en) * | 1992-01-27 | 1998-11-17 | Icos Corporation | Humanized antibodies specific for ICAM related protein |
US6153395A (en) * | 1992-01-27 | 2000-11-28 | Icos Corporation | ICAM-related protein |
EP0604624A4 (en) * | 1992-06-22 | 1997-03-12 | Miles Inc | Multimeric forms of human rhinovirus receptor protein. |
US5879712A (en) | 1995-06-07 | 1999-03-09 | Sri International | Method for producing drug-loaded microparticles and an ICAM-1 dosage form so produced |
US20020168367A1 (en) | 2000-04-28 | 2002-11-14 | Planet Biotechnology Incorporated | Novel immunoadhesins for treating and preventing viral and bacterial diseases |
CN101643512A (en) | 2000-04-28 | 2010-02-10 | 行星生物技术有限公司 | Novel immunoadhesin for the prevention of rhinovirus infection |
Citations (65)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4171365A (en) * | 1977-08-05 | 1979-10-16 | Sterling Drug Inc. | Antiviral aryloxyalkylpyrazoles |
GB2022826A (en) * | 1978-06-12 | 1979-12-19 | Corning Glass Works | Measuring Antigen Receptors on Cell Membranes |
US4209526A (en) * | 1977-08-05 | 1980-06-24 | Sterling Drug Inc. | Antiviral arylenedioxyalkyl substituted pyrazoles |
US4232161A (en) * | 1979-10-24 | 1980-11-04 | Sterling Drug Inc. | 4-[6-(2-Chloro-4-methoxyphenoxy)hexyl]-3,5-diethyl-1-(2-pyridinyl)-1H-pyrazole |
US4234725A (en) * | 1979-10-24 | 1980-11-18 | Sterling Drug Inc. | 4-[6-(2-Chloro-4-methoxyphenoxy)hexyl]-3,5-diethyl-1-[4-(4-morpholinyl)-1-oxobutyl]-1H-pyrazole |
US4261928A (en) * | 1977-08-05 | 1981-04-14 | Sterling Drug Inc. | 2-Benzoyl-8-(2-chloro-4-methoxyphenoxy)-1-phenyl-1-octanone |
US4372976A (en) * | 1981-08-07 | 1983-02-08 | Sterling Drug Inc. | Novel aryl-aliphatic ketone and its use as an antiviral agent |
US4427653A (en) * | 1981-01-26 | 1984-01-24 | President And Fellows Of Harvard College | Method of making monoclonal antibodies |
US4451476A (en) * | 1982-12-13 | 1984-05-29 | Sterling Drug Inc. | Isoxazoles as antiviral agents |
EP0169146A2 (en) * | 1984-07-20 | 1986-01-22 | Merck & Co. Inc. | Monoclonal antibodies directed against the cellular receptor of human rhinovirus |
EP0169729A2 (en) * | 1984-07-23 | 1986-01-29 | Becton Dickinson and Company | Recovery of cell receptors |
EP0192175A2 (en) * | 1985-02-15 | 1986-08-27 | BOEHRINGER INGELHEIM INTERNATIONAL GmbH | Rhinovirus strain HRV2 polypeptides and DNA molecules encoding them |
EP0207453A2 (en) * | 1985-07-02 | 1987-01-07 | Sterling Winthrop Inc. | Heterocyclic substituted-phenoxyalkyl-isoxazoles and-furans, their preparation and use as antiviral agents |
EP0227604A2 (en) * | 1985-12-23 | 1987-07-01 | Sandoz Ag | Use of oligopeptides in the treatment of viral infections |
EP0261403A2 (en) * | 1986-08-23 | 1988-03-30 | BOEHRINGER INGELHEIM INTERNATIONAL GmbH | Polypeptide of rhinovirus strain HRV89, and DNA molecule encoding it |
EP0280578A2 (en) * | 1987-02-26 | 1988-08-31 | Dana-Farber Cancer Institute, Inc. | Purification of LFA-3 |
WO1988006592A1 (en) * | 1987-02-26 | 1988-09-07 | Dana-Farber Cancer Institute, Inc. | Cloning of lfa-1 |
AU1463088A (en) * | 1987-04-14 | 1988-10-20 | Boehringer Ingelheim International Gmbh | Receptor of the small rhinovirus receptor group |
EP0289949A2 (en) * | 1987-05-04 | 1988-11-09 | Dana Farber Cancer Institute | Intercellular adhesion molecules, and their binding ligands |
EP0314863A2 (en) * | 1987-11-02 | 1989-05-10 | Baylor College Of Medicine | Use of ICAM-1 or its functional derivatives for the treatment of non-specific inflammation |
AU2633288A (en) * | 1987-05-04 | 1989-05-18 | Dana-Farber Cancer Institute | Intercellular adhesion molecules and their binding ligands |
EP0319815A2 (en) * | 1987-12-08 | 1989-06-14 | Miles Inc. | Transfectant cell lines which express the major human rhinovirus receptor |
US4843087A (en) * | 1983-08-29 | 1989-06-27 | Sterling Drug Inc. | Di-heterocyclic compounds and their use as antiviral agents |
WO1989010938A1 (en) * | 1988-05-04 | 1989-11-16 | Dana-Farber Cancer Institute | Protein micelles |
PT91570A (en) * | 1988-09-01 | 1990-03-30 | Molecular Therapeutics Inc | METHOD FOR OBTAINING A HUMAN RHINOVIRUS RECEPTOR PROTEIN THAT INHIBITS VIRUS INFECTIVITY |
EP0362526A2 (en) * | 1988-08-23 | 1990-04-11 | Dana Farber Cancer Institute | The Alpha-subunit of the LFA-1 leukocyte adhesion receptor |
EP0364690A2 (en) * | 1988-08-23 | 1990-04-25 | Dana Farber Cancer Institute | The alpha-subunit of the Mac-1 leukocyte adhesion receptor |
EP0365837A2 (en) * | 1988-09-28 | 1990-05-02 | Dana Farber Cancer Institute | Intercellular adhesion molecules, and their binding ligands |
PT92920A (en) * | 1989-01-24 | 1990-07-31 | Molecular Therapeutics Inc | METHOD FOR THE PRODUCTION OF A SOLUABLE MOLECULATE RELATED BUT DIFFERENT FROM ICAM-1 |
EP0380068A1 (en) * | 1989-01-24 | 1990-08-01 | Miles Inc. | An expression system for production of chimeric monoclonal antibodies |
US4956281A (en) * | 1987-06-03 | 1990-09-11 | Biogen, Inc. | DNA sequences, recombinant DNA molecules and processes for producing lymphocyte function associated antigen-3 |
EP0387668A1 (en) * | 1989-03-09 | 1990-09-19 | Center For Blood Research Laboratories, Inc. | Intercellular adhesion molecule - 2 and its binding ligands |
AU5129990A (en) * | 1989-03-16 | 1990-09-20 | Dana-Farber Cancer Institute | Intercellular adhesion molecules and their binding ligands |
EP0391088A2 (en) * | 1989-03-16 | 1990-10-10 | Center For Blood Research Laboratories, Inc. | Use of functional derivatives of the intercellular adhesion molecule ICAM-1 in anti-viral therapy |
EP0459577A2 (en) * | 1990-06-01 | 1991-12-04 | Merck & Co. Inc. | Microbially expressed portions of a monoclonal antibody block rhinovirus attachment to cell receptors |
US5081228A (en) * | 1988-02-25 | 1992-01-14 | Immunex Corporation | Interleukin-1 receptors |
EP0468257A1 (en) * | 1990-07-20 | 1992-01-29 | Bayer Corporation | Multimeric form of human rhinovirus receptor protein |
US5109123A (en) * | 1988-06-14 | 1992-04-28 | Dana Farber Cancer Institute | Alteration of ability of soluble CD4 fragments to bind HIV |
EP0488061A2 (en) * | 1990-11-28 | 1992-06-03 | Center For Blood Research Laboratories, Inc. | The MAC-1 binding site of ICAM-1 |
EP0387701B1 (en) * | 1989-03-09 | 1992-08-12 | Boehringer Ingelheim Pharmaceuticals Inc. | Use of intercellular adhesion molecules, and their binding ligands in the treatment of asthma |
EP0510483A1 (en) * | 1991-04-22 | 1992-10-28 | Boehringer Ingelheim Pharmaceuticals Inc. | Method for the detection of viruses |
US5179017A (en) * | 1980-02-25 | 1993-01-12 | The Trustees Of Columbia University In The City Of New York | Processes for inserting DNA into eucaryotic cells and for producing proteinaceous materials |
US5235049A (en) * | 1989-01-24 | 1993-08-10 | Molecular Therapeutics, Inc. | Nucleic acid sequences encoding a soluble molecule (SICAM-1) related to but distinct from ICAM-1 |
US5240694A (en) * | 1991-09-23 | 1993-08-31 | University Of Virginia | Combined antiviral and antimediator treatment of common colds |
EP0566554A2 (en) * | 1992-03-13 | 1993-10-20 | Monsanto Company | Production of recombinant proteins using herpes virus promoters and VP16 transactivators |
US5284931A (en) * | 1987-05-04 | 1994-02-08 | Dana Farber Cancer Institute | Intercellular adhesion molecules, and their binding ligands |
US5304636A (en) * | 1987-04-14 | 1994-04-19 | Boehringer Ingelheim International Gmbh | Receptor for the human rhinovirus minor group |
US5324510A (en) * | 1989-09-01 | 1994-06-28 | Boehringer Ingelheim Pharmaceuticals, Inc. | Use of antibodies to intercellular adhesion molecule-1 (ICAM-1) in the treatment of asthma |
US5340800A (en) * | 1990-08-27 | 1994-08-23 | Liu David Y | Peptide medicaments for the treatment of disease |
US5349053A (en) * | 1990-06-01 | 1994-09-20 | Protein Design Labs, Inc. | Chimeric ligand/immunoglobulin molecules and their uses |
US5359046A (en) * | 1990-12-14 | 1994-10-25 | Cell Genesys, Inc. | Chimeric chains for receptor-associated signal transduction pathways |
US5372933A (en) * | 1988-10-03 | 1994-12-13 | The Scripps Research Institute | Polypeptides that mimic receptor-induced binding sites, and methods of using same |
US5395929A (en) * | 1987-12-15 | 1995-03-07 | Dana Farber Cancer Institute | Isolated nucleic acid encoding the alpha subunit of the human leukocyte adhesion receptor |
US5472849A (en) * | 1991-05-03 | 1995-12-05 | Boehringer Ingelheim Pharmaceuticals, Inc. | Method for detecting inflammation |
US5525487A (en) * | 1992-01-27 | 1996-06-11 | Icos Corporation | DNA encoding I-CAM related protein |
US5532127A (en) * | 1992-01-27 | 1996-07-02 | Icos Corporation | Assay for 1-CAM related protein expression |
US5580969A (en) * | 1992-07-24 | 1996-12-03 | The United States Of America As Represented By The Secretary Of The Navy | Antisense oligonucleotides directed against human ICAM-I RNA |
US5589453A (en) * | 1988-09-01 | 1996-12-31 | Molecular Therapeutics, Inc. | Human rhinovirus receptor protein (ICAM-1) that inhibits rhinovirus attachment and infectivity |
US5597567A (en) * | 1991-10-04 | 1997-01-28 | The United States Of America As Represented By The Department Of Health And Human Services | Blocking cell adhesion molecules and treating animals with ocular inflammation |
US5603932A (en) * | 1987-04-14 | 1997-02-18 | Boehringer Ingelheim International Gmbh | Receptor of the minor human rhinovirus receptor group |
US5663293A (en) * | 1992-01-27 | 1997-09-02 | Icos Corporation | ICAM-related protein |
US5674982A (en) * | 1990-07-20 | 1997-10-07 | Bayer Corporation | Multimeric form of human rhinovirus receptor protein |
US5686582A (en) * | 1990-07-20 | 1997-11-11 | Bayer Corporation | Multimeric forms of human rhinovirus receptor protein |
US5821341A (en) * | 1989-01-24 | 1998-10-13 | Bayer Corporation | Antibodies to sICAM-1 |
US5831036A (en) * | 1987-05-04 | 1998-11-03 | Dana Farber Cancer Institute | Soluble fragments of human intercellular adhesion molecule-1 |
-
1991
- 1991-07-06 AT AT91111272T patent/ATE184049T1/en not_active IP Right Cessation
- 1991-07-06 EP EP98124642A patent/EP0987329A3/en not_active Withdrawn
- 1991-07-06 DK DK91111272T patent/DK0468257T3/en active
- 1991-07-06 EP EP91111272A patent/EP0468257B1/en not_active Expired - Lifetime
- 1991-07-06 DE DE69131564T patent/DE69131564T2/en not_active Expired - Lifetime
- 1991-07-06 ES ES91111272T patent/ES2134762T3/en not_active Expired - Lifetime
- 1991-07-17 IL IL98866A patent/IL98866A0/en unknown
- 1991-07-18 FI FI913470A patent/FI105687B/en not_active IP Right Cessation
- 1991-07-18 JP JP03202211A patent/JP3091527B2/en not_active Expired - Lifetime
- 1991-07-19 IE IE255291A patent/IE912552A1/en not_active IP Right Cessation
- 1991-07-19 PT PT98394A patent/PT98394B/en not_active IP Right Cessation
- 1991-07-19 ZA ZA915678A patent/ZA915678B/en unknown
- 1991-07-20 KR KR1019910012433A patent/KR100208847B1/en not_active IP Right Cessation
-
1994
- 1994-10-04 US US08/318,039 patent/US6096862A/en not_active Expired - Lifetime
-
1999
- 1999-11-05 GR GR990402859T patent/GR3031768T3/en unknown
Patent Citations (84)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4209526A (en) * | 1977-08-05 | 1980-06-24 | Sterling Drug Inc. | Antiviral arylenedioxyalkyl substituted pyrazoles |
US4261928A (en) * | 1977-08-05 | 1981-04-14 | Sterling Drug Inc. | 2-Benzoyl-8-(2-chloro-4-methoxyphenoxy)-1-phenyl-1-octanone |
US4171365A (en) * | 1977-08-05 | 1979-10-16 | Sterling Drug Inc. | Antiviral aryloxyalkylpyrazoles |
GB2022826A (en) * | 1978-06-12 | 1979-12-19 | Corning Glass Works | Measuring Antigen Receptors on Cell Membranes |
US4232161A (en) * | 1979-10-24 | 1980-11-04 | Sterling Drug Inc. | 4-[6-(2-Chloro-4-methoxyphenoxy)hexyl]-3,5-diethyl-1-(2-pyridinyl)-1H-pyrazole |
US4234725A (en) * | 1979-10-24 | 1980-11-18 | Sterling Drug Inc. | 4-[6-(2-Chloro-4-methoxyphenoxy)hexyl]-3,5-diethyl-1-[4-(4-morpholinyl)-1-oxobutyl]-1H-pyrazole |
US5179017A (en) * | 1980-02-25 | 1993-01-12 | The Trustees Of Columbia University In The City Of New York | Processes for inserting DNA into eucaryotic cells and for producing proteinaceous materials |
US4427653A (en) * | 1981-01-26 | 1984-01-24 | President And Fellows Of Harvard College | Method of making monoclonal antibodies |
US4372976A (en) * | 1981-08-07 | 1983-02-08 | Sterling Drug Inc. | Novel aryl-aliphatic ketone and its use as an antiviral agent |
US4451476A (en) * | 1982-12-13 | 1984-05-29 | Sterling Drug Inc. | Isoxazoles as antiviral agents |
US4843087A (en) * | 1983-08-29 | 1989-06-27 | Sterling Drug Inc. | Di-heterocyclic compounds and their use as antiviral agents |
EP0169146A2 (en) * | 1984-07-20 | 1986-01-22 | Merck & Co. Inc. | Monoclonal antibodies directed against the cellular receptor of human rhinovirus |
EP0169729A2 (en) * | 1984-07-23 | 1986-01-29 | Becton Dickinson and Company | Recovery of cell receptors |
EP0192175A2 (en) * | 1985-02-15 | 1986-08-27 | BOEHRINGER INGELHEIM INTERNATIONAL GmbH | Rhinovirus strain HRV2 polypeptides and DNA molecules encoding them |
EP0207453A2 (en) * | 1985-07-02 | 1987-01-07 | Sterling Winthrop Inc. | Heterocyclic substituted-phenoxyalkyl-isoxazoles and-furans, their preparation and use as antiviral agents |
EP0227604A2 (en) * | 1985-12-23 | 1987-07-01 | Sandoz Ag | Use of oligopeptides in the treatment of viral infections |
EP0261403A2 (en) * | 1986-08-23 | 1988-03-30 | BOEHRINGER INGELHEIM INTERNATIONAL GmbH | Polypeptide of rhinovirus strain HRV89, and DNA molecule encoding it |
EP0280578A2 (en) * | 1987-02-26 | 1988-08-31 | Dana-Farber Cancer Institute, Inc. | Purification of LFA-3 |
WO1988006592A1 (en) * | 1987-02-26 | 1988-09-07 | Dana-Farber Cancer Institute, Inc. | Cloning of lfa-1 |
EP0287076B1 (en) * | 1987-04-14 | 1993-03-24 | BOEHRINGER INGELHEIM INTERNATIONAL GmbH | Receptor of the minor rhinovirus receptor group |
US5603932A (en) * | 1987-04-14 | 1997-02-18 | Boehringer Ingelheim International Gmbh | Receptor of the minor human rhinovirus receptor group |
DE3712678A1 (en) * | 1987-04-14 | 1988-10-27 | Boehringer Ingelheim Int | RECEPTOR OF THE SMALL RHINOVIRUS RECEPTOR GROUP |
AU1463088A (en) * | 1987-04-14 | 1988-10-20 | Boehringer Ingelheim International Gmbh | Receptor of the small rhinovirus receptor group |
US5304636A (en) * | 1987-04-14 | 1994-04-19 | Boehringer Ingelheim International Gmbh | Receptor for the human rhinovirus minor group |
US5712245A (en) * | 1987-04-14 | 1998-01-27 | Boehringer Ingelheim International Gmbh | Receptor of the minor human rhinovirus receptor group |
EP0289949A2 (en) * | 1987-05-04 | 1988-11-09 | Dana Farber Cancer Institute | Intercellular adhesion molecules, and their binding ligands |
US5831036A (en) * | 1987-05-04 | 1998-11-03 | Dana Farber Cancer Institute | Soluble fragments of human intercellular adhesion molecule-1 |
US5612216A (en) * | 1987-05-04 | 1997-03-18 | Dana Farber Cancer Institute | Nucleotide sequence encoding intercellular adhesion molecule-1 and fragments thereof |
AU1551888A (en) * | 1987-05-04 | 1988-11-10 | Dana-Farber Cancer Institute | Intercellular adhesion molecules and their binding ligands |
AU2633288A (en) * | 1987-05-04 | 1989-05-18 | Dana-Farber Cancer Institute | Intercellular adhesion molecules and their binding ligands |
US5475091A (en) * | 1987-05-04 | 1995-12-12 | The Dana Farber Cancer Institute | R6-5-D6, an antibody which binds intercellular adhesion molecule-1 |
US5284931A (en) * | 1987-05-04 | 1994-02-08 | Dana Farber Cancer Institute | Intercellular adhesion molecules, and their binding ligands |
US4956281A (en) * | 1987-06-03 | 1990-09-11 | Biogen, Inc. | DNA sequences, recombinant DNA molecules and processes for producing lymphocyte function associated antigen-3 |
EP0314863A2 (en) * | 1987-11-02 | 1989-05-10 | Baylor College Of Medicine | Use of ICAM-1 or its functional derivatives for the treatment of non-specific inflammation |
EP0319815A2 (en) * | 1987-12-08 | 1989-06-14 | Miles Inc. | Transfectant cell lines which express the major human rhinovirus receptor |
EP0319815B1 (en) * | 1987-12-08 | 1994-08-31 | Miles Inc. | Transfectant cell lines which express the major human rhinovirus receptor |
US5395929A (en) * | 1987-12-15 | 1995-03-07 | Dana Farber Cancer Institute | Isolated nucleic acid encoding the alpha subunit of the human leukocyte adhesion receptor |
US5081228A (en) * | 1988-02-25 | 1992-01-14 | Immunex Corporation | Interleukin-1 receptors |
WO1989010938A1 (en) * | 1988-05-04 | 1989-11-16 | Dana-Farber Cancer Institute | Protein micelles |
US5109123A (en) * | 1988-06-14 | 1992-04-28 | Dana Farber Cancer Institute | Alteration of ability of soluble CD4 fragments to bind HIV |
EP0362526A2 (en) * | 1988-08-23 | 1990-04-11 | Dana Farber Cancer Institute | The Alpha-subunit of the LFA-1 leukocyte adhesion receptor |
EP0364690A2 (en) * | 1988-08-23 | 1990-04-25 | Dana Farber Cancer Institute | The alpha-subunit of the Mac-1 leukocyte adhesion receptor |
NZ230474A (en) * | 1988-09-01 | 1993-03-26 | Miles Inc | Detergent-complexed human rhinovirus receptor: (intercellular adhesion molecule-1 (icam-1) fragments) |
PT91570A (en) * | 1988-09-01 | 1990-03-30 | Molecular Therapeutics Inc | METHOD FOR OBTAINING A HUMAN RHINOVIRUS RECEPTOR PROTEIN THAT INHIBITS VIRUS INFECTIVITY |
IL91454A (en) * | 1988-09-01 | 1995-08-31 | Molecular Therapeutics Inc | Use of a human rhinovirus receptor preparation for the manufacture of medicaments for the treatment of rhinovirus infections |
EP0362531A1 (en) * | 1988-09-01 | 1990-04-11 | Bayer Corporation | A human rhinovirus receptor protein that inhibits virus infectivity |
US5589453A (en) * | 1988-09-01 | 1996-12-31 | Molecular Therapeutics, Inc. | Human rhinovirus receptor protein (ICAM-1) that inhibits rhinovirus attachment and infectivity |
EP0365837A2 (en) * | 1988-09-28 | 1990-05-02 | Dana Farber Cancer Institute | Intercellular adhesion molecules, and their binding ligands |
US5372933A (en) * | 1988-10-03 | 1994-12-13 | The Scripps Research Institute | Polypeptides that mimic receptor-induced binding sites, and methods of using same |
US5821341A (en) * | 1989-01-24 | 1998-10-13 | Bayer Corporation | Antibodies to sICAM-1 |
US5849699A (en) * | 1989-01-24 | 1998-12-15 | Bayer Corporation | Soluble molecule related to but distinct from ICAM-1 |
AU4876790A (en) * | 1989-01-24 | 1990-08-02 | Molecular Therapeutics, Inc. | A soluble molecule related to but distinct from ICAM-1 |
KR100202435B1 (en) * | 1989-01-24 | 1999-06-15 | 골든 피.폴리 | A soluble molecule (sicam-1) related but distinct from icam-1 |
EP0379904A1 (en) * | 1989-01-24 | 1990-08-01 | Bayer Corporation | A soluble molecule related to but distinct from ICAM-1 |
EP0380068A1 (en) * | 1989-01-24 | 1990-08-01 | Miles Inc. | An expression system for production of chimeric monoclonal antibodies |
US5235049A (en) * | 1989-01-24 | 1993-08-10 | Molecular Therapeutics, Inc. | Nucleic acid sequences encoding a soluble molecule (SICAM-1) related to but distinct from ICAM-1 |
NZ232203A (en) * | 1989-01-24 | 1992-10-28 | Molecular Therapeutics Inc | Human soluble intercellular adhesion molecule-1 (sicam-1), dna encoding it, antibodies and pharmaceutical compositions |
PT92920A (en) * | 1989-01-24 | 1990-07-31 | Molecular Therapeutics Inc | METHOD FOR THE PRODUCTION OF A SOLUABLE MOLECULATE RELATED BUT DIFFERENT FROM ICAM-1 |
EP0387701B1 (en) * | 1989-03-09 | 1992-08-12 | Boehringer Ingelheim Pharmaceuticals Inc. | Use of intercellular adhesion molecules, and their binding ligands in the treatment of asthma |
EP0387668A1 (en) * | 1989-03-09 | 1990-09-19 | Center For Blood Research Laboratories, Inc. | Intercellular adhesion molecule - 2 and its binding ligands |
AU5129990A (en) * | 1989-03-16 | 1990-09-20 | Dana-Farber Cancer Institute | Intercellular adhesion molecules and their binding ligands |
EP0391088A2 (en) * | 1989-03-16 | 1990-10-10 | Center For Blood Research Laboratories, Inc. | Use of functional derivatives of the intercellular adhesion molecule ICAM-1 in anti-viral therapy |
US5730983A (en) * | 1989-09-01 | 1998-03-24 | Boehringer Ingelheim Pharmaceuticals, Inc. | Use of intercellular adhesion molecules, and their binding ligands in the treatment of asthma |
US5324510A (en) * | 1989-09-01 | 1994-06-28 | Boehringer Ingelheim Pharmaceuticals, Inc. | Use of antibodies to intercellular adhesion molecule-1 (ICAM-1) in the treatment of asthma |
US5349053A (en) * | 1990-06-01 | 1994-09-20 | Protein Design Labs, Inc. | Chimeric ligand/immunoglobulin molecules and their uses |
EP0459577A2 (en) * | 1990-06-01 | 1991-12-04 | Merck & Co. Inc. | Microbially expressed portions of a monoclonal antibody block rhinovirus attachment to cell receptors |
EP0468257A1 (en) * | 1990-07-20 | 1992-01-29 | Bayer Corporation | Multimeric form of human rhinovirus receptor protein |
US5686581A (en) * | 1990-07-20 | 1997-11-11 | Bayer Corporation | Multimeric form of human rhinovirus receptor protein |
US5871733A (en) * | 1990-07-20 | 1999-02-16 | Bayer Corporation | Multimeric forms of human rhinovirus receptor protein |
US5686582A (en) * | 1990-07-20 | 1997-11-11 | Bayer Corporation | Multimeric forms of human rhinovirus receptor protein |
US5674982A (en) * | 1990-07-20 | 1997-10-07 | Bayer Corporation | Multimeric form of human rhinovirus receptor protein |
US5340800A (en) * | 1990-08-27 | 1994-08-23 | Liu David Y | Peptide medicaments for the treatment of disease |
EP0488061A2 (en) * | 1990-11-28 | 1992-06-03 | Center For Blood Research Laboratories, Inc. | The MAC-1 binding site of ICAM-1 |
US5359046A (en) * | 1990-12-14 | 1994-10-25 | Cell Genesys, Inc. | Chimeric chains for receptor-associated signal transduction pathways |
EP0510483A1 (en) * | 1991-04-22 | 1992-10-28 | Boehringer Ingelheim Pharmaceuticals Inc. | Method for the detection of viruses |
US5472849A (en) * | 1991-05-03 | 1995-12-05 | Boehringer Ingelheim Pharmaceuticals, Inc. | Method for detecting inflammation |
US5422097A (en) * | 1991-09-23 | 1995-06-06 | University Of Virginia | Combined antiviral and antimediator treatment of common colds |
US5240694A (en) * | 1991-09-23 | 1993-08-31 | University Of Virginia | Combined antiviral and antimediator treatment of common colds |
US5597567A (en) * | 1991-10-04 | 1997-01-28 | The United States Of America As Represented By The Department Of Health And Human Services | Blocking cell adhesion molecules and treating animals with ocular inflammation |
US5663293A (en) * | 1992-01-27 | 1997-09-02 | Icos Corporation | ICAM-related protein |
US5532127A (en) * | 1992-01-27 | 1996-07-02 | Icos Corporation | Assay for 1-CAM related protein expression |
US5525487A (en) * | 1992-01-27 | 1996-06-11 | Icos Corporation | DNA encoding I-CAM related protein |
EP0566554A2 (en) * | 1992-03-13 | 1993-10-20 | Monsanto Company | Production of recombinant proteins using herpes virus promoters and VP16 transactivators |
US5580969A (en) * | 1992-07-24 | 1996-12-03 | The United States Of America As Represented By The Secretary Of The Navy | Antisense oligonucleotides directed against human ICAM-I RNA |
Non-Patent Citations (362)
Title |
---|
"Chapter 9, Introduction of DNA into Mammalian Cells", Current Protocols in Molecular Biology 1997: 9.0.1-9.9.16 (1997). |
Abraham, G. and Colonno, R. J., "Many Rhinovirus Serotypes Share the Same Cellular Receptor", J. Virol. 51:340-345 (1984). |
Abraham, G. and Colonno, R. J., Many Rhinovirus Serotypes Share the Same Cellular Receptor , J. Virol. 51:340 345 (1984). * |
Abraham, G. and R.J. Colonno, "Characterization of human rhinoviruses displaced by an anti-receptor monoclonal antibody", J. Virol.62(7):2300-2306 (Jul. 1988). |
Al-Nakib, W., P.G. Higgins, G.I. Barrow, D.A.J. Tyrrell, K. Andries, G. Vanden Bussche, N. Taylor, and P.A.J. Janssen, "Suppression of Colds in Human Volunteers Challenged with Rhinoviurs by a New Synthetic Drug (R61837)", Antimicrobial Agents and Chemotherapy 33(4): 522-525 (Apr. 1989). |
Amzel, L. M., and R.J. Poljak, "Three-Dimensional Structure of Immunoglobulins", Ann. Rev. Biochem. 48: 961-997 (1979). |
Anasetti et al., "Activation of Natural Killer Cells by LFA-3 Binding to CD2", 4th International Conference on Human Leukocyte Differentiation Antigens, Vienna, Austria, Feb. 21-25, 1989, Tissue Antigens (1989) 33(2), 73. |
Anasetti et al., Activation of Natural Killer Cells by LFA 3 Binding to CD2 , 4 th International Conference on Human Leukocyte Differentiation Antigens, Vienna, Austria, Feb. 21 25, 1989, Tissue Antigens (1989) 33(2), 73. * |
Argenbright et al., "Monoclonal Antibodies to the Leukocyte Membrane CD18 Glycoprotein Complex and to Intercellular Adhesion Molecule-1 Inhibit Leukocyte-Endothelial Adhesion in Rabbits", J. Leukoc. Biol. 49:253-257 (1991). |
Argenbright et al., Monoclonal Antibodies to the Leukocyte Membrane CD18 Glycoprotein Complex and to Intercellular Adhesion Molecule 1 Inhibit Leukocyte Endothelial Adhesion in Rabbits , J. Leukoc. Biol. 49:253 257 (1991). * |
Argenbright, L. W. and Barton, R. W., "Interactions of Leukocyte Integrins with Intercellular Adhesion Molecule-1 in the Production of Inflammatory Vascular Injury In Vivo: the Shwartzman Reaction Revisited", J. Clin. Invest. 89(1):259-272 (1992). |
Argenbright, L. W. and Barton, R. W., Interactions of Leukocyte Integrins with Intercellular Adhesion Molecule 1 in the Production of Inflammatory Vascular Injury In Vivo: the Shwartzman Reaction Revisited , J. Clin. Invest. 89(1):259 272 (1992). * |
Ashkenazi, A., L.G. Presta, S.A. Marsters, T.R. Camerato, K.A. Rosen, B.M. Fendly, and D.J. Capon, "Mapping the CD4 binding site for human immunodeficiency virus by alanine scanning mutagenesis", Proc. Natl. Acad. Sci. USA 87:7150-7154 (Sep. 1990). |
Associated Press, "Common Colds: Nasal Spray May Help Keep The Sniffles Away", Atlanta Constitution, Sep. 20, 1995. |
Associated Press, "Cure For The Cold? No, But Prevention May Be Spray Away", San Diego Union-Tribune, Sep. 20, 1995. |
Associated Press, "Doctors Sniffing Out Spray to Fight Colds", Denver Post, Sep. 20, 1995. |
Associated Press, "Drug Sprays Away Colds", New York Post, Sep. 20, 1995. |
Associated Press, "Nasal Spray May Prevent Sniffles", Miami Herald, Sep. 20, 1995. |
Associated Press, "Scientists Feel They Can Develop Spray To Keep The Sniffles Away", The Spectator, Sep. 20, 1995. |
Associated Press, "Simple Nasal Spray May Be Able To Keep Common Cold Away. Medicine Successful On Chimps So Far", Washington Times, Sep. 20, 1995. |
Associated Press, "Someday Soon, A Simple Sniff Should Snuff The Sniffles", Houston Chronicle, Sep. 20, 1995. |
Associated Press, No Cure, But Nothing To Sniff(le) At. Nasal Spray To Block Common Cold Is In The Works, Minneapolis Star Tribune, Sep. 20, 1995. |
Badger et. al., "Structure Analysis of a Series of Antiviral Agents Complexed with Human Rhinovirus 14", PNAS 85:3304-3308 (1988). |
Badger et. al., Structure Analysis of a Series of Antiviral Agents Complexed with Human Rhinovirus 14 , PNAS 85:3304 3308 (1988). * |
Bangham, C. R. M. and McMichael, A. J., Nosing ahead in the cold war Nature 334:16 (1990). * |
Bebbington, C. R., and Hentschel, C. C. G. "The use of vectors based on gene amplification for the expression of cloned genes in mammalian cells" DNA Cloning 3:163-186 (1987). |
Bebbington, C. R., and Hentschel, C. C. G. The use of vectors based on gene amplification for the expression of cloned genes in mammalian cells DNA Cloning 3:163 186 (1987). * |
Becker, J. W., and G.N.Reeke, Jr., "Three-dimensional structure of β2 -microglobulin", Proc. Natl. Acad. Sci. USA 82: 4225-4229 (Jun. 1985). |
Becker, J. W., H.P. Erickson, S. Hoffman, B.A. Cunningham, and G.M. Edelman, "Topology of cell adhesion molecules", Proc. Natl. Acad. Sci. USA, 86: 1088-1092 (Feb. 1989). |
Bjorkman, P. J., M.A. Saper, B. Samraoui, W.S. Bennett, J.L. Strominger, and D.C. Wiley, "Structure of the human class I histocompatility antigen, HLA-A2", Nature 329: 506-512 (Oct. 1987). |
Blann, A. D., "Cell Hybrids: an important new source o antibody production" Med. Lab. Sci. 36:329-338 (1979). |
Blann, A. D., Cell Hybrids: an important new source o antibody production Med. Lab. Sci. 36:329 338 (1979). * |
Bock et al., "Characterization of soluble forms of NCAM", FEBS Lett 225(1,2):33-36 (1987). |
Bock et al., Characterization of soluble forms of NCAM , FEBS Lett 225(1,2):33 36 (1987). * |
Bowie et al., "Deciphering the Message in Protein Sequences: Tolerance to Amino Acid Substitutions", Science 247:1306-1310 (1990). |
Bowie et al., Deciphering the Message in Protein Sequences: Tolerance to Amino Acid Substitutions , Science 247:1306 1310 (1990). * |
Braude, A. (ed.s), "Infectious Diseases and Medical Microbiology, 2nd edition, W.B. Saunders Co., Philadelphia, PA, (1986) chapter 65 Picornaviruses", pp. 521-529. |
British Biotechnology, Ltd. (Oxford, England), 1993 Product Catalog, Item # BBE 1, "Soluble ICAM-1 Elisa". |
Brodsky, M.H., M. Warton, R.M. Myers, and D.R. Littman, "Analysis of the site in CD4 that binds to the HIV envelope glycoprotein", J. Immunol. 144(8):3078-3086 (Apr. 1990). |
Callahan, P.L., S. Mizutani, and R.J. Colonno, "Molecular cloning and complete sequence determination of RNA genome of human rhinovirus type 14", Proc. Natl. Acad. Sci. USA 82(3):732-6 (Feb. 1985). |
Campbell, B. A. and Cords, C. E., "Monoclonal Antibodies That Inhibit Attachment of Group B Coxsackieviruses", J. Virol. 48(2):561-564 (1983). |
Campbell, B. A. and Cords, C. E., Monoclonal Antibodies That Inhibit Attachment of Group B Coxsackieviruses , J. Virol. 48(2):561 564 (1983). * |
Capon et al., "Designing CD4 immunoadhesins for AIDS therapy", Nature 337:525-531 (1989). |
Capon et al., Designing CD4 immunoadhesins for AIDS therapy , Nature 337:525 531 (1989). * |
Cate et al., "Isolation of the Bovine and Human Genes for Mullerian Inhibiting Substance and Expression of the Human Gene in Animal Cells", Cell 45:685-698 (1986). |
Cate et al., Isolation of the Bovine and Human Genes for M u llerian Inhibiting Substance and Expression of the Human Gene in Animal Cells , Cell 45:685 698 (1986). * |
Cole et al., "Topographic Localization of the Heparin-binding Domain of the Neural Cell Adhesion Molecule N-CAM", J. Cell Biol. 103:1739-1744 (1986). |
Cole et al., Topographic Localization of the Heparin binding Domain of the Neural Cell Adhesion Molecule N CAM , J. Cell Biol. 103:1739 1744 (1986). * |
Colman, P.M., "Structure of Antibody-Antigen Complexes: Implications for Immune Recognition", Advances in Immunology 43: 99-132 (1988). |
Colonno et al., "Isolation of a Monoclonal Antibody that Blocks Attachment of the Major Group of Human Rhinoviruses", J. Virology 57:7-12 (1986). |
Colonno et al., Isolation of a Monoclonal Antibody that Blocks Attachment of the Major Group of Human Rhinoviruses , J. Virology 57:7 12 (1986). * |
Colonno, R. J. and Tomassini, J. E., "Viral Receptors: A Novel Approach For The Prevention Of Human Rhinovirus Infection", in Medical Virology VI, de la Maza, L. M. and E. M. Peterson, eds. (Elsevier, New York, 1987) 331-351. |
Colonno, R. J. and Tomassini, J. E., Viral Receptors: A Novel Approach For The Prevention Of Human Rhinovirus Infection , in Medical Virology VI , de la Maza, L. M. and E. M. Peterson, eds. (Elsevier, New York, 1987) 331 351. * |
Colonno, R. J., J.H. Condra, S. Mizutani, P.L. Callahan, M.-E.Davies, and M.A. Murcko, "Evidence for the direct involvement of the rhinovirus canyon in receptor binding", Proc. Natl. Acad. Sci. USA 85: 5449-5453 (Aug. 1988). |
Colonno, R.J., "Cell surface receptors for picornaviruses", Bioassays 5(6):270-4 (1986). |
Colonno, R.J., "Molecular interactions between human rhinoviruses and the adhesion receptor ICAM-1", in Microb. Adhes. Invasion, [Proc. Symp.], meeting date 1990, Hook et al., eds. (Springer, NY, 1992), pp. 33-41. |
Colonno, R.J., "Molecular interactions between human rhinoviruses and their cellular receptors", Seminars in Virol. 3(2):101-107 (1992). |
Colonno, R.J., "Virus receptors: the Achilles' heel of human rhinoviruses", in Innovations in Antiviral Development and the Detection of Virus Infection, T. Block et al., eds., (Plenum Press, NY, 1992), pp. 61-70. |
Colonno, R.J., G. Abraham, and J.E. Tomassini, "Molecular and biochemical aspects of human rhinovirus attachment to cellular receptors", in Molecular Aspects of Picornavirus Infection and Detection, [Presentations ICN-UCI Int. Conf. Virol.], Meeting Date 1988, Semler et al., eds. (Am. Soc. Microbiol., Washington, DC, 1989), pp. 169-178. |
Colonno, R.J., J.E. Tomassini, and P.L. Callahan, "Isolation and characterization of a monoclonal antibody which blocks attachment of human rhinoviruses", in UCLA Symposia on Molecular and Cellular Biology , New Series, vol. 54, Positive Strand RNA Viruses, Keystone, CO Apr. 20-26, 1986, Brinton et al., eds. (Alan R. Liss, Inc., NY, 1987), pp. 93-102. |
Colonno, R.J., J.E. Tomassini, and P.L. Callahn, "Huan rhinovirus attachment requires a specific cellular receptor protein", in Symposium on Positive Strand RNA Viruses, 15th Annual Meeting of the UCLA Symposia on Molecular and Cellular Biology, Apr. 20-26, 1986, J. Cell. Biochem Suppl., 0 (10 Part D):266, #Q4 (1986). |
Colonno, R.J., J.E. Tomassini, P.L. Callahan, and W.J. Long, "Characterization of the cellular receptor specific for attachment of most human rhinovirus serotypes", in Virus Attachment Entry Cells, Proc. ASM Conf., Meeting Date 1985, Crowell et al., eds. (Am. Soc. Microbiol. Washington, DC, 1986), pp. 109-115. |
Colonno, R.J., J.H. Condra, and S. Mizutani, "Interaction of cellular receptors with the canyon structure of human rhinoviruses", in UCLA Symposia on Molecular and Cellular Biology New Series, vol. 90, Cell Biology of Virus Entry, Replication, and Pathogenesis, Taos, NM, Feb. 28-Mar. 5, 1988, Compans et al., eds. (Alan R. Liss, Inc., NY, 1988) pp. 75-84. |
Colonno, R.J., J.H. Condra, S. Mizutani, G. Abraham, P.L. Callahan, J.E. Tomassini, and M.A. Murcko, "Evidence for direct involvement of the rhinovirus canyon with cellular receptors", in Symposium on Cell Biology of Virus Entry, Replication and Pathogenesis, Positive Strand RNA Viruses, 17th Annual UCLA meeting on Molecular and Cellular Biology, Taos, NM, Feb. 28-Mar. 5, 1988, J. Cell. Biochem. Suppl., 0 (12 Part C):4, #J005 (1988). |
Colonno, R.J., P.L. Callahan, D.M. Leippe, R.R. Rueckert, and J.E. Tomassini, "Inhibition of rhinovirus attachment by neutralizing monoclonal antibodies and their Fab fragments," J. Virol. 63(1):36-42 (Jan. 1989). |
Colonno, R.J., R.B. Register, D.W. Lineberger, and C.R. Uncapher, "Identification of ICAM-1 residues critical for attachment of human rhinoviruses", Meeting on Molecular Biology of Human Pathogenic Viruses held at the 20th Annual Meeting of the Keystone Symposia on Molecular and Cellular Biology, Lake Tahoe, CA, Mar. 8-15, 1991, J. Cell Biochem. Suppl. 15(Part E):82, #M310 (1991). |
Colonno, R.J., R.L. LaFemina, C.M. DeWitt, and J.E. Tomassini, "The major-group rhinoviruses utilize the intercellular adhesion molecule 1 ligand as a cellular receptor during infection", in New Aspects of Positive-Strand RNA Viruses, Second International Symposium, Vienna, Austria, Meeting Date 1989, Brinton et al., eds. (Am. Soc. Microbiol., Washington, DC, 1990), pp. 257-261. |
Condra, J.H., V.V. Sardan, J.E. Tomassini, A.J. Schlabach, M.-E. Davies, D.W. Lineberger, D.J. Graham, and R.J. Colonno,, "Bacterial expression of antibody fragments that block human rhinovirus infection of cultured cells", J. Biol. Chem. 265(4):2292-2295 (Feb. 1990). |
Cooper, G.M., "Cellular Transforming Genes", Science 217: 801-806 (1982). |
Cooper, G.M., Cellular Transforming Genes , Science 217: 801 806 (1982). * |
Cordingley, M.G., P.L. Callahan, V.V. Sardana, V.M. Garsky, and R.J. Colonno, "Substrate requirements of human rhinovirus 3C protease for peptide cleavage in vitro", J. Biol. Chem. 265(16):9062-5 (1990). |
Cordingley, M.G., R.B. Register, P.l. Callahan, V.M. Garsky, and R.J. Colonno, "Cleavage of small peptides in vitro by human rhinovirus 14 3C protease expressed in Escherichia coli", J. Virol. 63(12):5037-45 (Dec. 1989). |
Couch et al., "Effect of Route Inoculation on Experimental Respiratory Viral Disease in Volunteers and Evidence for Airborne Transmission", Bacteriol. Rev. 30:517-529 (1966). |
Couch et al., Effect of Route Inoculation on Experimental Respiratory Viral Disease in Volunteers and Evidence for Airborne Transmission , Bacteriol. Rev. 30:517 529 (1966). * |
Couch, R.B., "Rhinoviruses", Virology, Second Edition, edited by B. N. Fields, D. M. Knipe et al. Raven Press, Ltd., New York, 607-629 (1990). |
Couch, R.B., Rhinoviruses , Virology , Second Edition, edited by B. N. Fields, D. M. Knipe et al. Raven Press, Ltd., New York, 607 629 (1990). * |
Craig, A. G. and A.R. Berendt, "The Role of ICAM-1 as a Receptor for Rhinovirus and Malaria", in Integrins and ICAM-1 in Immune Responses, N. Hodd, ed. (Chem Immunol. Basel, Karger, 1991), vol. 50, pp. 116-134 (1991). |
Creighton, T.E., Proteins by W. H. Freeman and Company, New York, 33 34 (1984). * |
Creighton, T.E., Proteins by W. H. Freeman and Company, New York, 33-34 (1984). |
Crump et al., "In Vitro Inhibitory Activity of Soluble ICAM-1 for the Numbered Serotypes of Human Rhinovirus", Antiviral Chemistry and Chemother. 4(6):323-327 (1993). |
Crump et al., In Vitro Inhibitory Activity of Soluble ICAM 1 for the Numbered Serotypes of Human Rhinovirus , Antiviral Chemistry and Chemother. 4(6):323 327 (1993). * |
Crump, C. E., Arruda, and F.G. Hayden, "Comparative Antirhinoviral Activities of Soluble Intercellular Adhesion Molecule-1 (sICAM-1) and Chimeric ICAM-1/Immunoglobulin A Molecule", Antimicrobial Agents and Chemotherapy 38(6): 1425-1427 (Jun. 1994). |
Cunningham et al., "Neural Cell Adhesion Molecule: Structure, Immunoglobulin-Like Domains, Cell Surface Modulation, and Alternative RNA Splicing", Science 236:799-806 (1987). |
Cunningham et al., Neural Cell Adhesion Molecule: Structure, Immunoglobulin Like Domains, Cell Surface Modulation, and Alternative RNA Splicing , Science 236:799 806 (1987). * |
Cybulsky, M. I. and Gimbrone, Jr., M. A., "Endothelial Expression of a Mononuclear Leukocyte Adhesion Molecule During Atherogenesis", Science 251:788-791 (1991). |
Cybulsky, M. I. and Gimbrone, Jr., M. A., Endothelial Expression of a Mononuclear Leukocyte Adhesion Molecule During Atherogenesis , Science 251:788 791 (1991). * |
D Alessio et al., Short Duration Exposure and the Transmission of Rhinoviral Colds , J. Inf. Dis. 150(2):189 193 (1984). * |
D'Alessio et al., "Short-Duration Exposure and the Transmission of Rhinoviral Colds", J. Inf. Dis. 150(2):189-193 (1984). |
Dayhoff, M. O., W.C. Barker, and L. T. Hunt, "Establishing Homologies in Protein Sequences", Methods in Enzymology 91: 524-545 (1983). |
Dearden, C., W. Al-Nakib, K. Andries, R. Woestenborghs, and D.A.J. Tyrrell, "Drug resistant rhinoviruses from the nose of experimentally treated volunteers", Arch. Virol. 109: 71-81 (1989). |
Deen et al., "A Soluble Form of CD4 (T4) Protein Inhibits AIDS Virus Infection", Nature 331:82-86 (1988). |
Deen et al., A Soluble Form of CD4 (T4) Protein Inhibits AIDS Virus Infection , Nature 331:82 86 (1988). * |
Dewalt, P.G., M.A. Lawson, R.J. Colonno, and B.L. Semler, "Chimeric picornavirus polyproteins demonstrate a common 3C proteinase substrate specificity", J. Virol. 63(8):3444-3452 (1989). |
Dick, E.C., "Experimental Infection of Chimpanzees with Human Rhinovirus Types 14 and 43", Proceedings Of The Society For Experimental Biology And Medicine 127:1079-1081 (1968). |
Dick, E.C., and C.R. Dick, "Natural and Experimental Infections of Nonhuman Primates with Respiratory Viruses", Laboratory Animal Science 24(1): 177-181 (1974). |
Dick, E.C., Experimental Infection of Chimpanzees with Human Rhinovirus Types 14 and 43 , Proceedings Of The Society For Experimental Biology And Medicine 127:1079 1081 (1968). * |
Dochez et al., "Studies in the Common Cold. IV. Experimental Transmission of the Common Cold to Anthropoid Apes and Human Beings by Means of a Filtrable Agent", J. Exp. Med. 52:701-716 (1930). |
Dochez et al., Studies in the Common Cold. IV. Experimental Transmission of the Common Cold to Anthropoid Apes and Human Beings by Means of a Filtrable Agent , J. Exp. Med. 52:701 716 (1930). * |
Douglas et al., "Prophylactic Efficacy of Intranasal Alpha 2-Interferon Against Rhinovirus Infections in the Family Setting", The New England J. of Med. 314:65-70 (1986). |
Douglas et al., Prophylactic Efficacy of Intranasal Alpha 2 Interferon Against Rhinovirus Infections in the Family Setting , The New England J. of Med. 314:65 70 (1986). * |
Douglas, R. G., "Pathogenesis of Rhinovirus Common Colds in Human Volunteers", Annals of Otology, Rhinology and Laryngology 79:563-571 (1970). |
Douglas, R. G., Pathogenesis of Rhinovirus Common Colds in Human Volunteers , Annals of Otology, Rhinology and Laryngology 79:563 571 (1970). * |
Dustin et al., "Correlation of CD2 Binding and Functional Properties of Multimeric and Monomeric Lymphocyte Function-Associated Antigen 3", J. Exp. Med. 169:503-517 (1989). |
Dustin et al., "Induction by IL 1 and Inteferon-γ: Tissue Distribution, Biochemistry, and Function of a Natural Adherence Molecule (ICAM-1)", J. Immunol. 137(1):245-254 (1986). |
Dustin et al., "Supergene Families Meet in the Immune System" Immunology Today, 9(7 and 8):213-215 (1988). |
Dustin et al., Correlation of CD2 Binding and Functional Properties of Multimeric and Monomeric Lymphocyte Function Associated Antigen 3 , J. Exp. Med. 169:503 517 (1989). * |
Dustin et al., Induction by IL 1 and Inteferon : Tissue Distribution, Biochemistry, and Function of a Natural Adherence Molecule (ICAM 1) , J. Immunol. 137(1):245 254 (1986). * |
Dustin et al., Supergene Families Meet in the Immune System Immunology Today, 9(7 and 8):213 215 (1988). * |
Dustin, M. L. and T.A. Springer, "Lymphocyte Function-associated Antigen-1 (LFA-1) Interaction with Intercellular Adhesion Molecule-1 (ICAM-1) is One of At Least Three Mechanisms for Lymphocyte Adhesion to Cultured Endothelial Cells," J. Cell Biol. 107: 321-331 (Jul. 1988). |
Emini, E.A., W.A. Schleif, R.J. Colonno, and E. Wimmer, "Antigenic conservation and divergence between the viral-specific proteins of poliovirus type 1 and various picornaviruses", Virol. 140(1):13-20 (1985). |
Ey, P.L., et. al., Isolation of Pure IgG1, IgG2a, and IgG2b Immunoglobulins from Mouse Serum Using Protein A Sepharose , Immunochemistry 15:429 436 (1978). * |
Ey, P.L., et. al.,"Isolation of Pure IgG1, IgG2a, and IgG2b Immunoglobulins from Mouse Serum Using Protein A--Sepharose", Immunochemistry 15:429-436 (1978). |
Ezekovitz, R.A.B., R.B. Sim, G.G. MacPherson, and S. Gordon, "Interaction of Human Monocytes, Macrophages, and Polymorphonuclear Leukocytes with Zymosan in Vitro: Role of Type 3 Compliment Receptors and Macrophage Derived Complement", J. Clin. Invest. 76: 2368-2376 (Dec. 1985). |
Fisher et al., "HIV Infection is Blocked in vitro by Recombinant Soluble CD4", Nature 331:76-78 (1988). |
Fisher et al., HIV Infection is Blocked in vitro by Recombinant Soluble CD4 , Nature 331:76 78 (1988). * |
Fox et al., "Prevention of a Rhinovirus and Poliovirus Uncoating by WIN 51711, a New Antiviral Drug", Antimicrob. Ag. and Chemotherapy 30:110-116 (1986). |
Fox et al., Prevention of a Rhinovirus and Poliovirus Uncoating by WIN 51711, a New Antiviral Drug , Antimicrob. Ag. and Chemotherapy 30:110 116 (1986). * |
G u ssow, D. and Ploegh, H., Soluble class I antigens: a conundrum with no solution , Immunology Today 8(7,8):220 222 (1987). * |
Galfrey et. al., "Antibodies to Major Histocompatibility Antigens Produced by Hybrid Cell Lines", Nature 266:550-552 (1977). |
Galfrey et. al., Antibodies to Major Histocompatibility Antigens Produced by Hybrid Cell Lines , Nature 266:550 552 (1977). * |
Gennaro, A.R. (ed.), Remington's Pharmaceutical Sciences, 18th edition, Mack Publishing Co., Easton, PA (1990), "Drug Absorption, Action and Disposition", pp. 707-721. |
Gething, M.J. and Sambrook, J., "Construction of Influenza Haemagglutinin Genes that Code for Intracellular and Secreted Forms of the Protein" Nature 300:598-603 (1982). |
Gething, M.J. and Sambrook, J., Construction of Influenza Haemagglutinin Genes that Code for Intracellular and Secreted Forms of the Protein Nature 300:598 603 (1982). * |
Ginsberg et al., "Inhibition of Fibronectin Binding to Platelets by Proteolytic Fragments and Synthetic Peptides Which Support Fibroblast Adhesion", J. Biol. Chem. 260(7): 3931-3936 (1985). |
Ginsberg et al., Inhibition of Fibronectin Binding to Platelets by Proteolytic Fragments and Synthetic Peptides Which Support Fibroblast Adhesion , J. Biol. Chem. 260(7): 3931 3936 (1985). * |
Giranda et al., "Modelling of the Human Intercellular Adhesion Molecule-1, the Human Rhinovirus Major Group Receptor" Proteins: Structure, Function, and Genetics, 7:227-233 (1990). |
Giranda et al., Modelling of the Human Intercellular Adhesion Molecule 1, the Human Rhinovirus Major Group Receptor Proteins: Structure, Function, and Genetics, 7:227 233 (1990). * |
Gough, N., "Putting A Stop To An Immunoglobulin Message", Trends Genet. 3(9):238-240 (1987). |
Gough, N., Putting A Stop To An Immunoglobulin Message , Trends Genet. 3(9):238 240 (1987). * |
Gower et al., "Alternative Splicing Generates a Secreted Form of N-CAM in Muscle and Brain", Cell 55:955-964 (1988). |
Gower et al., Alternative Splicing Generates a Secreted Form of N CAM in Muscle and Brain , Cell 55:955 964 (1988). * |
Graham, F.L., and Van der Eb, A. J., "A New Technique for the Assay of Infectivity of Human Adenovirus 5 DNA", Virology 52: 456-467 (1973). |
Graham, F.L., and Van der Eb, A. J., A New Technique for the Assay of Infectivity of Human Adenovirus 5 DNA , Virology 52: 456 467 (1973). * |
Green et al., "Immunogenic Structure of the Influenza Virus Hemagglutinin", Cell 28:477-487 (1982). |
Green et al., Immunogenic Structure of the Influenza Virus Hemagglutinin , Cell 28:477 487 (1982). * |
Greve et al. "Mechanisms of Receptor-Mediated Rhinovirus Neutralization Defined by Two Soluble Forms of ICAM-1", J. Virology 65:6015-6023 (1991). |
Greve et al. Mechanisms of Receptor Mediated Rhinovirus Neutralization Defined by Two Soluble Forms of ICAM 1 , J. Virology 65:6015 6023 (1991). * |
Greve et al., "The Major Human Rhinovirus Receptor Is ICAM-1", Cell 56:839-847 (1989). |
Greve et al., The Major Human Rhinovirus Receptor Is ICAM 1 , Cell 56:839 847 (1989). * |
Greve, J. M., C.P. Forte, C.W. Marlor, A.M. Meyer, H. Hoover-Litty, D. Wunderlich, and A. McClelland "Mechanisms of Receptor-Mediated Rhinovirus Neutralization Defined by Two Soluble Forms of ICAM-1", J. Virol. 65(11): 6015-6023 (Nov. 1991). |
Gross Bellard et al., Isolation of High Molecular Weight DNA from Mammalian Cells , Eur. J. Biochem. 36:32 38 (1973). * |
Gross-Bellard et al., "Isolation of High-Molecular-Weight DNA from Mammalian Cells", Eur. J. Biochem. 36:32-38 (1973). |
Gussow, D. and Ploegh, H., "Soluble class I antigens: a conundrum with no solution?", Immunology Today 8(7,8):220-222 (1987). |
Guttman, N., and D. Baltimore, "Plasma Membrane Component Able to Bind and Alter Virions of Poliovirus Type 1: Sutides on Cell-Free Alteration Using a Simplified Assay", Virol. 82: 25-36 (1977). |
Gwaltney et al., Diagnostic Procedures for Viral, Rickettsial and Chlamydial Infections , N. J. Schmidt and R. W. Evans, Eds, 6th edition. p. 603, Am Pub. Health. Assoc., Washington D.C. (1989). * |
Gwaltney et al., Diagnostic Procedures for Viral, Rickettsial and Chlamydial Infections, N. J. Schmidt and R. W. Evans, Eds, 6th edition. p. 603, Am Pub. Health. Assoc., Washington D.C. (1989). |
Gwaltney, J. M., Jr., "Rhinovirus colds: epdimiology, clinical characteristics and transmission", Eur. J. Respir. Dis. 64 (suppl. 128): 336-339 (1983). |
Gwaltney, J. M., Jr., "Rhinoviruses", Yale J. Biol. Med. 48: 17-45 (1975). |
Gwaltney, J. M., Jr., and J.O. Hendley, "Rhinovirus Transmission: One if by Air, Two if by Hand", Trans. Am. Clin. Climatol. Assoc. 89: 194-200 (1977). |
Gwaltney, J. M.,Jr., and J.O. Hendley, "Rhinovirus Transmission One if by Air, Two if by Hand", Am. J. Epid. 107(5): 357-361 (May 1978). |
Halperin et al., "Exacerbations of Asthma in Adults During Experimental Rhinovirus Infection", Am. Rev. Respir. Dis. 132:976-980 (1985). |
Halperin et al., Exacerbations of Asthma in Adults During Experimental Rhinovirus Infection , Am. Rev. Respir. Dis. 132:976 980 (1985). * |
Hamparian et al., "A Collaborative Report: Rhinoviruses--Extension of the Numbering System from 89 to 100", Virology 159:191-192 (1987). |
Hamparian et al., A Collaborative Report: Rhinoviruses Extension of the Numbering System from 89 to 100 , Virology 159:191 192 (1987). * |
Haney, Daniel Q., "Beyond Chicken Soup. Nasal Spray Keeps Chimps From Catching Cold Virus", St. Louis Post Dispatch, Sep. 20, 1995. |
Haney, Daniel Q., "Nasal Spray Touted As Next-Best Thing To Cure For Colds", The Montreal Gazette, Sep. 20, 1995. |
Haney, Daniel Q., Associated Press, "For Colds, Nasal Spray Holds Hope. A Protein Swamps The Virus With Potential Targets In The Nose. Its a Decoy Trick", Philadelphia Inquirer, Sep. 20, 1995. |
Haney, Daniel Q., Associated Press, "Labs Busy Working On Nose Spray To Keep Colds Away", Charlotte Observer, Sep. 20, 1995. |
Haney, Daniel Q., Associated Press, "New Nasal Spray May Take Sniffles Out Of Common Cold", Cleveland Plain Dealer, Sep. 20, 1995. |
Haney, Daniel Q., Associated Press, "Out Front: Progress On Cold Front. Spray May Ward Off Sniffles. Medicine Is First To Block Infection", Sep. 19, 1995. |
Haney, Daniel Q., Associated Press, "Scientists Make Headway In Cold War With Nose Spray", Chicago Sun-Times, Sep. 20, 1995. |
Haney, Daniel Q., Associated Press, "Spray May Ward Off Sniffles. Nasal Treatment Studied To Keep Cold Viruses From Invading Victim", Denver--Rocky Mountain News, Sep. 20, 1995. |
Haney, Daniel Q., Associated Press, "The Cold War: Scientists Develop Spray That May End Sniffles", Arizona Republic, Sep. 20, 1995. |
Hardy et al., "Intranasal Drug Delivery by Spray and Drops", J. Pharm. Pharmacol. 37:294-297 (1985). |
Hardy et al., Intranasal Drug Delivery by Spray and Drops , J. Pharm. Pharmacol. 37:294 297 (1985). * |
Harning et al., "Serum Levels of Circulating Intercellular Adhesion Molecule 1 in Human Malignant Melanoma", Cancer Res. 51(8):5003-5005 (1991). |
Harning et al., Serum Levels of Circulating Intercellular Adhesion Molecule 1 in Human Malignant Melanoma , Cancer Res. 51(8):5003 5005 (1991). * |
Hayden et al., "Modification of Experimental Rhinovirus Colds by Receptor Blockade" Antiviral Research 9:233-247 (1988). |
Hayden et al., "Prevention of Natural Colds by Contact Prophylaxis with Intranasal Alpha2-Interferon", The New England Journal of Medicine, 314(2):71-75 (1986). |
Hayden et al., "Safety and Efficacy of Intranasal Pirodavir (R77975) in Experimental Rhinovirus Infection", Antimicrob. Agents Chemother. 36(4):727-732 (1992). |
Hayden et al., Modification of Experimental Rhinovirus Colds by Receptor Blockade Antiviral Research 9:233 247 (1988). * |
Hayden et al., Prevention of Natural Colds by Contact Prophylaxis with Intranasal Alpha2 Interferon , The New England Journal of Medicine, 314(2):71 75 (1986). * |
Hayden et al., Safety and Efficacy of Intranasal Pirodavir (R77975) in Experimental Rhinovirus Infection , Antimicrob. Agents Chemother. 36(4):727 732 (1992). * |
Hayden, F. G., and J.M. Gwaltney, Jr., "Intranasal Interferon-α2 Treatment of Experimental Rhinoviral Colds", J. Infect. Dis. 150(2): 174-180 (Aug. 1984). |
Hazuda, D., V. Sardana, P. Callahan, M. Cordingley, and R. Colonno, "Chemical approaches to mapping the active site thiol of human rhinovirus 3C protease", Joint Meeting of the American Society for Biochemistry and Molecular Biology and the American Association of Immunologists, New Orleans, LA, Jun. 4-7, 1990, Fed. Am. Soc. Exp. Biol. J. 4(7):#1605 (1990). |
Helenius, A. and Von Bonsdorff, C. H., "Semliki Forest Virus Membrane Proteins, Preparation and Characterization of Spike Complexes Soluble in Detergent-Free Medium" Biochimica et Biophysica Acta 436:895-899 (1976). |
Helenius, A. and Von Bonsdorff, C. H., Semliki Forest Virus Membrane Proteins, Preparation and Characterization of Spike Complexes Soluble in Detergent Free Medium Biochimica et Biophysica Acta 436:895 899 (1976). * |
Hendley et al., "Relation Between Naturally acquired Immunity and Infectivity of Two Rhinoviruses in Volunteers", J. Inf. Dis. 125:243-248 (1972). |
Hendley et al., "Transmission of Rhinovirus Colds By Self-Inoculation", The New England Journal of Medicine, 288(26):1361-1364 (Jun. 28, 1973). |
Hendley et al., Relation Between Naturally acquired Immunity and Infectivity of Two Rhinoviruses in Volunteers , J. Inf. Dis. 125:243 248 (1972). * |
Hendley, J. O., and Gwaltney, J. M., Jr., "Mechanisms of Transmission of Rhinovirus Infections", Epidemiologic Reviews, 10:242-257 (1988). |
Hendley, J.O., and J.M. Gwaltney, Jr., "Mechanisms of Transmission of Rhinovirus Infections", Epidemologic Reviews 10: 242-258 (1988). |
Holland, J. J. and McLaren, L. C., "The mammalian cell-virus relationship. II. Absorption, Reception and Eclipse of Poliovirus by HeLa Cells", J. Exp. Med. 109:487-504 (1959). |
Holland, J. J. and McLaren, L. C., The mammalian cell virus relationship. II. Absorption, Reception and Eclipse of Poliovirus by HeLa Cells , J. Exp. Med. 109:487 504 (1959). * |
Holland, J. J., "Receptor affinities as Major Determinants of Enterovirus Tissue Tropisms in Humans", Virology 15:312-326, 1961. |
Holland, J. J., Receptor affinities as Major Determinants of Enterovirus Tissue Tropisms in Humans , Virology 15:312 326, 1961. * |
Horley, K. J., C. Carpenito, B. Baker, and F. Takei, "Molecular cloning of murine intercellular adhesion molecule (ICAM-1)", EMBO J. 8(10): 2889-2896 (1989). |
Horton et al., "Gene Splicing by Overlap Extension: Tailor-Made Genes Using the Polyerase Chain Reaction", BioTechniques 8(5):528-535 (1990). |
Horton et al., Gene Splicing by Overlap Extension: Tailor Made Genes Using the Polyerase Chain Reaction , BioTechniques 8(5):528 535 (1990). * |
Hussey et. al., "A Soluble CD4 Protein Selectively Inhibits HIV Replication and Syncytium Formation" Nature, 331:78-81 (1988). |
Hussey et. al., A Soluble CD4 Protein Selectively Inhibits HIV Replication and Syncytium Formation Nature, 331:78 81 (1988). * |
Illum, L., "The Nasal Delivery of Peptides and Proteins", Trends in Biotech. 9:284-289 (1991). |
Illum, L., The Nasal Delivery of Peptides and Proteins , Trends in Biotech. 9:284 289 (1991). * |
Jacobs, K., C. Shoemaker, R. Rudersdorf, S.D. Neill, R.J. Kaufman, A. Mufson, J. Seehra, S.S. Jones, R. Hewick, E.F. Fritsch, M. Kawakita, T. Shimizu, and T. Miyake, "Isolation and characterization of genomic and cDNA clones of human erythropoietin", Nature 313: 806-810 (Feb. 1985). |
Johnston et al., "Viral Infections in Exacerbations in School Children with Cough or Wheeze: A Longitudinal Study", Am. Rev. Resp. Dis., 145:A546 (1992). |
Johnston et al., "Viruses as Precipitants of Asthma Symptoms. III. Rhinoviruses: Molecular Biology and Prospects for Future Intervention", Clin. Exp. Allergy, 23:237 (1993). |
Johnston et al., Viral Infections in Exacerbations in School Children with Cough or Wheeze: A Longitudinal Study , Am. Rev. Resp. Dis., 145:A546 (1992). * |
Johnston et al., Viruses as Precipitants of Asthma Symptoms. III. Rhinoviruses: Molecular Biology and Prospects for Future Intervention , Clin. Exp. Allergy, 23:237 (1993). * |
Johnston, S.C., M.L. Dustin, M.L. Hibbs, and T.A. Springer, "On the species specificity of the interaction of LFA-1 with intercellular adhesion molecules", J. Immunol. 145(4):1181-1187 (Aug. 1990). |
K u hn et al., Gene Transfer, Expression, and Molecular Cloning of the Human Transferrin Receptor Gene , Cell 37:95 103 (1984). * |
Kamarck, M. E., and Ruddle, F. H., "Somatic Cell Genetics and the Human Gene Map", Chapter 105 in Handbook of Experimental Immunology in Four Volumes, vol 3: Genetics and Molecular Immunology, D. M. Weir, ed. (Blackwell Scientific Publications, Boston, MA, 1986). |
Kamarck, M. E., and Ruddle, F. H., Somatic Cell Genetics and the Human Gene Map , Chapter 105 in Handbook of Experimental Immunology in Four Volumes, vol 3: Genetics and Molecular Immunology , D. M. Weir, ed. (Blackwell Scientific Publications, Boston, MA, 1986). * |
Katz et al., "Chromosome Mapping of Cell Membrane Antigens Expressed on Activated B Cells", Eur. J. Immunol., 15:103-106 (1985). |
Katz et al., Chromosome Mapping of Cell Membrane Antigens Expressed on Activated B Cells , Eur. J. Immunol., 15:103 106 (1985). * |
Kavenoff, R., and Zimm, B. H., "Chromosome-Sized DNA Molecules from Drosophila", Chromosoma (Berl.) 41:1-27 (1973). |
Kavenoff, R., and Zimm, B. H., Chromosome Sized DNA Molecules from Drosophila , Chromosoma (Berl.) 41:1 27 (1973). * |
Kim S., T.J. Smith, M.S. Chapman, M.G. Rossmann, D.C. Pevear, F.J. Dutko, P.J. Felock, G.D. Diana, and M.A. McKinlay, "Crystal Structure of Human Rhinovirus Serotype 1A (HRV1A)", J. Med. Biol. 210: 91-111 (1989). |
Kuhn et al., "Gene Transfer, Expression, and Molecular Cloning of the Human Transferrin Receptor Gene", Cell 37:95-103 (1984). |
Lamarre, D., D.J. Capon, D.R. Karp, T.Gregory, E.O. Long, and R.-P. Sekaly, "Class II MHC molecules and the HIV envelope glycoprotein interact with functionally distinct regions of the molecule", EMBO J. 8(11):3271-3277 (1989). |
Layne S. P., M.J. Merges, M. Dembo, J.L. Spouge, and P.L. Nara, "HIV requires multiple gp120 molecules for CD4-mediated infection", Nature 346: 277-279 (Jul. 1990). |
Lebman et al., "A Monoclonal Antibody that Detects Expression of Transferrin Receptor in Human Erythroid Precursor Cells", Blood 59(3):671-678 (1982). |
Lebman et al., A Monoclonal Antibody that Detects Expression of Transferrin Receptor in Human Erythroid Precursor Cells , Blood 59(3):671 678 (1982). * |
Lemanske et al., "Rhinovirus Upper Respiratory Infection Increases Airway Hyperreactivity and Late Asthmatic Reactions", J. Clin. Invest. 83:1-10 (1989). |
Lemanske et al., Rhinovirus Upper Respiratory Infection Increases Airway Hyperreactivity and Late Asthmatic Reactions , J. Clin. Invest. 83:1 10 (1989). * |
Leonard, W. J., J.M. Depper, G.R. Crabtree, S. Rudikoff, J. Pumphrey, R.J. Robb, M. Kronke, P.B. Svetlik, N.J. Peffer, T.A. Waldmann, and W.C. Greene, "Molecular cloning and expression of cDNAs for the human interleukin-2 receptor", Nature 311: 626-631 (Oct. 1984). |
Leszczynski, J. F., and G.D. Rose, "Loops in Globular Proteins: A Novel Category of Secondary Structure", Science 234: 849-855 (Nov. 1986). |
Lineberger, D. W., D.J. Graham, J.E. Tomassini, and R.J. Colonno, "Antibodies that Block Rhinovirus Attachment Map to Domain 1 of the Major Group Receptor", J. Virol. 64(6): 2582-2587 (Jun. 1990). |
Lineberger, D.W., C.R. Uncapher, D.J. Graham, and R.J. Colonno, "Domains 1 and 2 of ICAM-1 are sufficient to bind human rhinoviruses", Virus Research 24(2): 173-86 (1992). |
Littlefield, J.W., "Selection of Hybrids from Matings of Fibroblasts in vitro and Their Presumed Recombinants", Science 145:709-710 (1964). |
Littlefield, J.W., Selection of Hybrids from Matings of Fibroblasts in vitro and Their Presumed Recombinants , Science 145:709 710 (1964). * |
Livingston, D. J., and J.M. McPherson, "Protein Engineering: New Approaches to Improved Therapeutic Proteins, Part II", in Biotech. Trends, S. Petska, ed. (Pharmaceutical Technology, Jun. 1989). |
Lonberg Holm et al., Unrelated Animal Viruses Share Receptor , Nature 259:679 681 (1976). * |
Lonberg-Holm et al., "Unrelated Animal Viruses Share Receptor", Nature 259:679-681 (1976). |
Maddon, P.J., A.G. Dalgleish, J.S. McDougal, P.R. Clapham, R.A. Weiss, and R. Axel, "The T4 Gene Encodes the AIDS Virus Receptor and is Expressed in the Immune System and the Brain", Cell 47: 333-348 (Nov. 1986). |
Manning, Anita, "War on Bacteria Mix of Victories Amid Warnings", USA Today, Sep. 20, 1995. |
Margulies, D. H., et. al., "Engineering Soluble Major Histocompatibility Molecules: Why and How", Immunol. Res. 6: 101-116 (1987). |
Margulies, D. H., et. al., Engineering Soluble Major Histocompatibility Molecules: Why and How , Immunol. Res. 6: 101 116 (1987). * |
Marlin et al., "A Soluble Form of Intercellular Adhesion Molecule-1 Inhibits Rhinovirus Infection", Nature 344:70-72 (1990). |
Marlin et al., A Soluble Form of Intercellular Adhesion Molecule 1 Inhibits Rhinovirus Infection , Nature 344:70 72 (1990). * |
Marlin, S. D. et al., Cell 51:813-819 (1987) "Purified Intercellular Adhesion Molecule-1 (ICAM-1) . . . ". |
Marlin, S. D., et al., Cell 51:813-819 (Dec. 4, 1987), "Purified Intercellular adhesion molecule-1 (ICAM-1) is a ligand for lymphocyte function-associated antigen 1 (LFA-1)". |
Marlin, S.D. and Springer, T. A., "Purified Intercellular Adhesion Molecule-1 (ICAM-1) Is a Ligand for Lymphocyte Function-Associated Antigen 1 (LFA-1)", Cell 51:813-819 (1987). |
Marlin, S.D. and Springer, T. A., Purified Intercellular Adhesion Molecule 1 (ICAM 1) Is a Ligand for Lymphocyte Function Associated Antigen 1 (LFA 1) , Cell 51:813 819 (1987). * |
Marsh et al., "Antibody-toxin Conjugation", Immunotoxins by Kluwer Academic Publishers, Boston, Dordrecht, Lancaster 213-237 (1988). |
Marsh et al., "Interactions of Semliki Forest Virus Spike Glycoprotein Rosettes and Vesicle with Cultures Cells", J. Cell Biology 96:455-461 (1983). |
Marsh et al., Antibody toxin Conjugation , Immunotoxins by Kluwer Academic Publishers, Boston, Dordrecht, Lancaster 213 237 (1988). * |
Marsh et al., Interactions of Semliki Forest Virus Spike Glycoprotein Rosettes and Vesicle with Cultures Cells , J. Cell Biology 96:455 461 (1983). * |
Marsh, J. W., et al., in Immunotoxins, A. E. Frankel (ed), Kluwer Academic Publishers, Boston (1988), "Antibody-toxin conjugation". |
Marsh, J.W. et al., in Immunotoxins (Frankel, ed) Kluwer Academic Publishers (1988). pp. 213-237. |
Martin et al., "Efficient Neutralization and Disruption of Rhinovirus by Chimeric ICAM-1/Immunoglobulin Molecules", J. Virology, 67(6):3561-3568 (Jun. 1993). |
Martin, S., J.M. Casanovas, D.E. Staunton, and T.A. Springer, "Erfolgreiche Blockade von Rhinovirusinfektionen durch ICAM-1-Immunoglobulinchimare in vitro", Med. Klin. 88(4): 193-197 (1993). |
McClelland et al., "Identification of Monoclonal Antibody Epitopes and Critical Residues for Rhinovirus in Domain 1 of ICAM-1", PNAS 88(18):7993-7997 (1991). |
McClelland et al., "Transfectant cell lines which express the major human rhinovirus receptor, their preparation, and their uses", Immuno. 112:117179 (1990). |
McClelland et al., Identification of Monoclonal Antibody Epitopes and Critical Residues for Rhinovirus in Domain 1 of ICAM 1 , PNAS 88(18):7993 7997 (1991). * |
McClelland et al., Transfectant cell lines which express the major human rhinovirus receptor, their preparation, and their uses , Immuno. 112:117179 (1990). * |
McClelland, A., M.E.Kamarck, and F.H. Ruddle, "Molecular Cloning of Receptor Genes by Transfection", Methods in Enzymology 147: 280-291 (1987). |
McCray, J. and Werner, G., "Different Rhinovirus Serotypes Neutralized by Antipeptide Antibodies", Nature 329:736-738 (1987). |
McCray, J. and Werner, G., Different Rhinovirus Serotypes Neutralized by Antipeptide Antibodies , Nature 329:736 738 (1987). * |
McPherson, J. M., and D.J. Livingston, "Protein Engineering: New Approaches to Improved Therapeutic Proteins, Part I", in Biotech. Trends, S. Petska, ed. (Pharmaceutical Technology, May 1989). |
McPherson, J. M., and D.J. Livingston, "Protein Engineering: New Approaches to Improved Therapeutic Proteins, Part III", in Biotech. Trends, S. Petska, ed. (Pharmaceutical Technology, Sep. 1989). |
Medical Microbiology: "An Introduction to Infectious Diseases", 2nd ed., J.C. Sherris, ed. (Elsevier Science Publishing Co., Inc., N.Y. 1990) pp. 514-515. |
Medical Microbiology: An Introduction to Infectious Diseases , 2nd ed., J.C. Sherris, ed. (Elsevier Science Publishing Co., Inc., N.Y. 1990) pp. 514 515. * |
Medrano, L. and Green, H., "Picornavirus Receptors and Picornavirus Multiplication in Human-Mouse Hybrid Cell Lines", Virology 54:515-524 (1973). |
Medrano, L. and Green, H., Picornavirus Receptors and Picornavirus Multiplication in Human Mouse Hybrid Cell Lines , Virology 54:515 524 (1973). * |
Melchers et al. Lymphocyte Hybridomas , vol. 81 of Current Topics in Microbiology and Immunology, W. Arber, W. Henle, P.H. Hofschneider, J.H. Humphrey, J. Klein, P. Koldovsky, H. Koprowski, O. Maaloe, F. Melchers, R. Rott, H.G. Schweiger, L. Syrucek, P.K. Vogt, eds (Springer Verlang, New York, 1978). * |
Melchers et al. Lymphocyte Hybridomas, vol. 81 of Current Topics in Microbiology and Immunology, W. Arber, W. Henle, P.H. Hofschneider, J.H. Humphrey, J. Klein, P. Koldovsky, H. Koprowski, O. Maaloe, F. Melchers, R. Rott, H.G. Schweiger, L. Syrucek, P.K. Vogt, eds (Springer Verlang, New York, 1978). |
Mendelsohn et al., "Transformation of a Human Poliovirus Receptor Gene into Mouse Cells", PNAS 83:7845-7849 (1986). |
Mendelsohn et al., Transformation of a Human Poliovirus Receptor Gene into Mouse Cells , PNAS 83:7845 7849 (1986). * |
Mendelsohn, C.L., E. Wimmer, and V.R. Racaniello, "Cellular receptor for poliovirus: molecular cloning, nucleotide sequence, and expression of a new member of the immunoglobulin superfamily", Cell 56:855-865 (Mar. 1989). |
Minor et al., "Monoclonal antibodies which block cellular receptors of poliovirus", Virus Research 1:203-212 (1984). |
Minor et al., Monoclonal antibodies which block cellular receptors of poliovirus , Virus Research 1:203 212 (1984). * |
Minor, P. D., "Chapter 2: Growth, Assay and Purification of Picornaviruses", in Virology: a practical approach (IRL Press, Washington, D.C., 1985), pp. 25-41. |
Minor, P. D., P.A. Pipkin, D. Hockley, G.C. Schild, and J.W. Almond, "Monoclonal antibodies which block cellular receptors of poliovirus", Virus Res. 1: 203-212 (1984). |
Minor, P.D., "Growth, Assay and Purification of Picornaviruses", in Virology: A Practical Approach, B.W.J. Mahy, ed. (IRL Press Limited, Oxford, England), 25-41 (1985). |
Minor, P.D., Growth, Assay and Purification of Picornaviruses , in Virology: A Practical Approach , B.W.J. Mahy, ed. (IRL Press Limited, Oxford, England), 25 41 (1985). * |
Mizutani, S., and R.J. Colonno, In vitro synthesis of an infectious RNA from cDNA clones of human rhinovirus type 14;, J. Virol. 56(2):628-32 (Nov. 1985). |
Monitoring Report, "Cure For Colds Sep. 18 to Sep. 20", Video Monitoring Services of America, a Burrelle's Affiliate, New York, New York, pp. 1-3, Sep. 20, 1995. |
Morein B., "Potentiation of the Immune Response by Immunization with Antigens in Defined Multimeric Physical Forms", Vet. Immunol. Immunopathol. 17: 153-159 (1987). |
Morein, B., "Potentiation of the Immune Response by Immunization with Antigens in Defined Multimeric Physical Forms", Veterinary Immunology and Immunopathology 17:153-159 (1987). |
Morein, B., Potentiation of the Immune Response by Immunization with Antigens in Defined Multimeric Physical Forms , Veterinary Immunology and Immunopathology 17:153 159 (1987). * |
Niman et al., "Anti-peptide antibodies detect oncogene-related proteins in urine", PNAS 82:7924-7928 (1985). |
Niman et al., Anti peptide antibodies detect oncogene related proteins in urine , PNAS 82:7924 7928 (1985). * |
Nobis et al., "Production of a Monoclonal Antibody against an Epitope on HeLa Cells that Is the Functional Poliovirus Binding Site", J. Gen. Virol. 66:2563-2569 (1985). |
Nobis et al., Production of a Monoclonal Antibody against an Epitope on HeLa Cells that Is the Functional Poliovirus Binding Site , J. Gen. Virol. 66:2563 2569 (1985). * |
Ockenhouse, C.F., R. Betageri, T.A. Springer, and D.E. Staunton, "Plasmodium falciparum-Infected Erythrocytes Bind ICAM-1 at a Site Distinct from LFA-1, Mac-1, and Human Rhinovirus", Cell 68: 63-69 (Jan. 1992). |
Ohlin et al., "Spectrum of Activity of Soluble Intercellular Adhesion Molecule-1 Against Rhinovirus Reference Strains and Field Isolates", Antimicrob. Agents and Chemother. 38:1413-1415 (1994). |
Ohlin et al., Spectrum of Activity of Soluble Intercellular Adhesion Molecule 1 Against Rhinovirus Reference Strains and Field Isolates , Antimicrob. Agents and Chemother. 38:1413 1415 (1994). * |
Parham, P., "Monoclonal Antibodies Against HLA Products and Their use in Immunaffinity Purification," Methods in Enzymology 92:110-138 (1983). |
Parham, P., Monoclonal Antibodies Against HLA Products and Their use in Immunaffinity Purification, Methods in Enzymology 92:110 138 (1983). * |
Pepinsky et al., "The Increased Potency of Crossed-linked Lymphocyte Function-associated Antigen-3 (LFA-3) Multimers Is a Direct Consequence of Changes in Valency", J. Biol. Chem. 266(27):18244-18249 (1991). |
Pepinsky et al., The Increased Potency of Crossed linked Lymphocyte Function associated Antigen 3 (LFA 3) Multimers Is a Direct Consequence of Changes in Valency , J. Biol. Chem. 266(27):18244 18249 (1991). * |
Peppel, K., D. Crawford, and B. Beutler, "A Tumor Necrosis Factor (TNF) Receptor-IgG Heavy Chain Chimeric Protein as a Bivalent Antagonist of TNF Activity", J. Exp. Med. 174: 1483-1489 (Dec. 1991). |
Peterson, A. and Seed, B., "Genetic Analysis of Monoclonal Antibody and HIV Binding Sites on the Human Lymophocyte Antigen CD4", Cell 54:65-72 (1988). |
Peterson, A. and Seed, B., Genetic Analysis of Monoclonal Antibody and HIV Binding Sites on the Human Lymophocyte Antigen CD4 , Cell 54:65 72 (1988). * |
Pevear, D. C., M.J. Fancher, P.J. Felock, M.g. Rossmann, M.S. Miller, G. Diana, A.M. Treasurywala, M.A. McKinlay, and F.J. Dutko, "Conformational Change in the floor of the Human Rhinovirus Canyon Blocks Adsorption to HeLa Cell Receptors", J. Virol. 63(5): 2002-2007 (May 1989). |
Plow, E. F., M.D. Pierschbacher, E. Ruoslahti, G.A. Marguerie, and M.H. Ginsberg, "The effect of Arg-Gly-Asp-containing peptides on fibrinogen and von Willebrand factor binding to platelets", Proc. Natl. Acad. Sci. USA 82: 8057-8061 (1985). |
R&D Systems (Minneapolis, MN), 1994 Catalog, Item # BBE 1B, "Human Soluble ICAM-1". |
Ray, C. G., "Chapter 32: Respiratory Viruses", in Medical Microbiology, an Introduction to Infectious Diseases, 2nd Ed, J. C. Sherris, ed. (Elsevier, New York, 1990), pp. 499-516. |
Register, R.B., C.R. Uncapher, A.M. Naylor, D.W. Lineberger, and R.J. Colonno, "Human-murine chimeras of ICAM-1 identify amino acid residues critical for rhinovirus and antibody binding", J. Virol. 65(12):6589-6596 (Dec. 1991). |
Roesing, T. G., P.A. Toselli, and R.L. Crowell, "Elution and Uncoating of Coxsackievirus B3 by Isolated HeLa Cell Plasma Membranes", J. Virol. 15(3): 654-667 (Mar. 1975). |
Rossman et al., "Structure of a Human Common Cold Virus and Functional Relationship to other Picornaviruses", Nature 317: 145-153 (1985). |
Rossman et al., Structure of a Human Common Cold Virus and Functional Relationship to other Picornaviruses , Nature 317: 145 153 (1985). * |
Rossmann, M. G., "The Canyon Hypothesis. Hiding the Host Cell Receptor Attachment Site on a Viral Surface from Immune Surveillance", J. Biol. Chem. 264(25): 14587-14590 (Sep. 1989). |
Rothlein et al., "A Form of Circulating ICAM-1 In Human Serum", J. Immunol. 147(11):3788-3793 (1991). |
Rothlein et al., "A Human Intercellular Adhesion Molecule (ICAM-1) Distinct From LFA-1", J. Immuno. 137(4):1270-1274 (1986). |
Rothlein et al., A Form of Circulating ICAM 1 In Human Serum , J. Immunol. 147(11):3788 3793 (1991). * |
Rothlein et al., A Human Intercellular Adhesion Molecule (ICAM 1) Distinct From LFA 1 , J. Immuno. 137(4):1270 1274 (1986). * |
Ruddle et al., "DNA-Mediated Gene Transfer in Mammalian Gene Cloning", Genetic Engineering 6:319-338 (1984). |
Ruddle et al., DNA Mediated Gene Transfer in Mammalian Gene Cloning , Genetic Engineering 6:319 338 (1984). * |
Rueckert, R. B. Sherry, A. Mosser, R. Colonno, and M. Rossman, "Location of four neutralization antigens on the three-dimensional surface of a common-cold picornavirus, human rhinovirus 14", in Virus Attachment Entry Cells, Proc. ASM Conf., Meeting date 1985, Crowell et al., eds. (Am. Soc. Microbiol., Washington, DC, 1986), pp. 21-27. |
Ruoslahti et al., "Synthetic Peptides in the Analysis of Cell Adhesion," in Synthetic Peptides in Biology and Medicine Elsvier Science Publishers, pp. 191-197 (1985). |
Ruoslahti et al., Synthetic Peptides in the Analysis of Cell Adhesion, in Synthetic Peptides in Biology and Medicine Elsvier Science Publishers, pp. 191 197 (1985). * |
Saiki et al., "Enzymatic Amplification of β-Globin Genomic Sequences and Restriction Site Analysis for Diagnosis of Sicle Cell Anemia," Science 230:1350-1354 (1985). |
Saiki et al., Enzymatic Amplification of Globin Genomic Sequences and Restriction Site Analysis for Diagnosis of Sicle Cell Anemia, Science 230:1350 1354 (1985). * |
Saiki, R.K., D.H. Gelfand, S. Stoffel, S.J. Scharf, R. Higuchi, G.T. Horn, K.B. Mullis, and H.A. Erlich, "Primer-Directed Enzymatic Amplification of DNA with a Thermostable DNA Polymerase", Science 239: 487-491 (Jan. 1988). |
Sambrook et al., Molecular Cloning: A Laboratory Manual, 2d ed. (Cold Spring Harbor Laboratory Press, Cold Spring Harbor, NY, 1989) pp. 1.21-1.52. |
Sayre, P.H., R.E. Hussey, H.-C. Chang, T.L. Ciardelli, and E.L. Reinherz, "Structural and Binding Analysis of a Two Domain Extracellular CD2 Molecule", J. Exp. Med. 169: 995-1009 (Mar. 1989). |
Schipper et al., "The Nasal Mucocilliary Clearance: Relevance to Nasal Drug Delivery", Pharm. Res. 8:807-814 (1991). |
Scopes, R.K., "Separation By Precipitation," in Protein Purification: Principles & Practice (1982) Springler Verlag, NY, pp. 39-46. |
Seed, B. and Aruffo, A., "Molecular Cloning of the CD2 antigen, the T-Cell Erythrocyte Receptor, by a Rapid Immunoselection Procedure," PNAS 84:3365-3369 (1987). |
Seed, B., "An LFA-3 cDNA Encodes a Phospholipid-Linked Membrane Protein Homologous to its Receptor CD2," Nature 329: 840-842 (1987). |
Seth et al., "Circulating ICAM-1 isoforms: Diagnostic Prospects for Inflammatory and Immune Disorders," Lancet 338:83-84 (1991). |
Sherman-Gold, R., "Companies Pursue Therapies Based on Complex Cell Adhesion Molecules", Genetic Engineering News pp. 6-7,14 (Jul. 1993). |
Sherry, B. and Rueckert, R., "Evidence for at Least Two Dominant Neutralization Antigens on Human Rhinovirus 14," J. Virol. 53(1):137-143 (1985). |
Sherry, B., A. G. Mosser, R.J. Colonno, and R.R. Rueckert, "Use of monoclonal antibodies to identify four neutralizing immunogens on a common cold picornavirus, human rhinovirus 14", J. Virol. 57(1):246-57 (Jan. 1986). |
Shih, C. and Weinberg, R. A., "Isolation of a Transforming Sequence from a Human Bladder Carcinoma Cell Line," Cell 29: 161-169 (1982). |
Shipkowitz et al., "Antiviral Activity of a bis-Benzimidazole Against Experimental Rhinovirus Infections in Chimpanzees", App. Microbiol. 23(1):117-122 (1972). |
Siddique et al., "The Poliovirus Sensitivity (PVS) Gene Is on Chromosome 19q12->q13.2", Genomics 3:156-160 (1988). |
Simmons et al., "ICAM, an Adhesion Ligand of LFA-1, is Homologous to the Neural Cell Adhesion Molecule NCAM," Nature 331:624-627 (1988). |
Simons et al., "Formation of Protein Micelles from Amphiphilic Membrane Proteins", PNAS 75(11):5306-5310 (1978). |
Siu, G., S.M. Hedrick, and A.A. Brian, "Isolation of the Murine Intercellular Adhesion Molecule 1 (ICAM-1) Gene", J. Immun. 143(11): 3813-3820 (Dec. 1989). |
Skern, T., W. Sommergruber, D. Blass, P. Gruendler, F. Fraundorfer, C. Pieler, I. Fogy, and E. Kuechler, "Human rhinovirus 2: complete nucleotide sequence and proteolytic processing signals in the capsid protein region", Nucleic Acids Research 13(6): 2111-2126 (1985). |
Skerra, A. and Pluckthun, A., "Assembly of a Functional Immunoglobulin FV Fragment in Escherichia coli" Science, 240: 1038-1041 (1988). |
Smilek, D.E., D.C. Wraith, S. Hodgkinson, S. Swivedy, L. Steinman, and H.O. McDevitt, "A single amino acid change in a mylelin basic protein peptide confers the capacity to prevent rather than induce experimental autoimmune encephalomyelitis", Proc. Natl. Acad. Sci. USA 88: 9633-9637 (Nov. 1991). |
Smith et al., "Blocking of HIV-1 Infectivity by a Soluble, Secreted Form of the CD4 Antigen," Science 238:1704-1707 (1987). |
Smith et al., "Modification and Secretion of Human Interleukin 2 Produced in Insect Cells by a Baculovirus Expression Vector", PNAS 82:8404-8408 (1985). |
Smith, T.J., et. al., "The Site of Attachment in Human Rhinovirus 14 for 4 Antiviral Agents that Inhibit Uncoating", Science 233:1286-1293 (1986). |
Springer, T.A., "Adhesion Receptors of the Immune System", Nature 346:425-434 (1990). |
Staunton et al., "A Cell Adhesion Molecule, ICAM-1, is the Major Surface Receptor for Rhinoviruses," Cell 56:849-853 (1989). |
Staunton et al., "Primary Structure of ICAM-1 Demonstrates Interaction between Members of the Immunoglobulin and Integrin Supergene Families," Cell 52:925-933 (1988). |
Staunton et al., "The Arrangement of the Immunoglobulin-Like Domains of ICAM-1 and the Binding Sites for LFA-1 and Rhinovirus," Cell 61:243-254 (1990). |
Staunton, D. E., et al., Cell 61:243-254 (Apr. 20, 1990), "The arrangement of the immunoglobulin-like domains of ICAM-1 and the binding sites for LFA-1 and rhinovirus". |
Staunton, D.E., C.F. Ockenhouse, and T.A. Springer, "Soluble Intercellular Adhesion Molecule 1-Immunoglobulin G1 Immunoadhesin Mediates Phagocytosis of Malaria-infected Erythrocytes", J. Exp. Med. 176: 1471-1476 (Nov. 1992). |
Staunton, D.E., M.L. Dustin, and T.A. Springer, "Functional cloning of ICAM-2, a cell adhesion ligand for LFA-1 homologous to ICAM-1", Nature 339: 61-64 (May 1989). |
Steis et al., "Serum Soluble IL-2 Receptor as a Tumor Marker in Patients with Hairy Cell Leukemia", Blood 71(5):1304-1309 (May 1988). |
Sundquist et al., "Influenza Virus ISCOMs: Antibody Response in Animals", Vaccine 6:49-53 (1988). |
Sundquist et al., "Influenza Virus ISCOMs: Biochemical Characterization", Vaccine 6:44-48 (1988). |
Suter, David, Associated Press, "Tests for a Nasal Spray to Deflect Cold Viruses", New York Times, Sep. 20, 1995. |
Tomassini et al., "cDNA Cloning Reveals that the Major Group Rhinovirus Receptor on HeLa Cells is Intercellular Adhesion Molecule 1," PNAS 86:4907-4911 (1989). |
Tomassini, J. E., et al., J. Virology 58(2):290-295 (May, 1986), "Isolation of a receptor protein involved in attachment of human rhinoviruses". |
Tomassini, J.E. and Colonno, R. J., "Isolation of a Receptor Protein Involved in Attachment of Human Rhinoviruses," J. Virol. 58(2):290-295 (1986). |
Tomassini, J.E. et al., J. Virol. 58(2):290-295 (1986) "Isolation of a receptor protein involved in attachment of human rhinoviruses". |
Tomassini, J.E., "Isolation, Characterization and Cloning of the Cellular Receptor for the Major Group of Human Rhinoviruses," Ph.D. Thesis, University of Pennsylvania (1986). |
Tomassini, J.E., and R.J. Colonno, "Isolation and characterization of a cellular receptor involved in attachment of human rhinoviruses to cells", in Symposium on Positive Strand RNA Viruses, 15th Annual Meeting of the UCLA Symposia on Molecular and Cellular Biology, Apr. 20-26, 1986, J. Cell. Biochem. Suppl., 0 (10 Part D):300, #Q92 (1986). |
Tomassini, J.E., T.R. Maxson, and R.J. Colonno, "Biochemical characterization of a glycoprotein required for rhinovirus attachment", J. Biol. Chem. 264(3):1656-1662 (Jan. 1989). |
Towbin et. al., "Electrophoretic Transfer of Proteins from Polyacrylamide Gels to Nitrocellulose Sheets: Procedure and Some Applications", PNAS 76(9):4350-4354 (1979). |
Towbin, H., et al., PNAS 76:4350-4354 (1979), "Electrophoretic transfer of protiens from polyacrylamide gels to nitrocellulose sheets: procedure and some applications". |
Traunecker et al., "Highly Efficient Neutralization of HIV with Recombinant CD4-Immunoglobulin Molecules," Nature 339: 68-70 (1989). |
Traunecker et al., "Soluble CD4 Molecules Neutralize Human Immunodeficiency Virus Type 1" Nature 331:84-86 (1988). |
Turner et al., "Efficacy of Oral WIN 54954 for Prophylaxis of Experimental Rhinovirus Infection", 37:297-300 (1993). |
Uncapher, C. R., C.M. DeWitt, and R.J. Colonno, "The Major and Minor Group Receptor Families Contain All but One Human Rhinovirus Serotype", Virology 180: 814-817 (1991). |
Urlaub, G. and Chasin, L. A., "Isolation of Chinese Hamster Cell Mutants Deficient in Dihydrofolate Reductase Activity," PNAS USA 77(7):4216-4220 (1980). |
Wade, N., "Hybridomas: A Potent New Biotechnology," Science 208:692-693 (1980). |
Weis, W., J.H. Brown, S. Cusack, J.C. Paulson, J.J. Skehel, and D.C. Wiley, "Structure of the influenza virus haemagglutinin complexed with its receptor, sialic acid", Nature 333: 426-431 (Jun. 1988). |
Welsh, K.I., "Antibody Production Made Easier," Nature 266: 495 (1977). |
Wickner W. T., and H.F. Lodish, "Multiple Mechanisms of Protein Insertion Into and Across Membranes", Science 230: 400-407 (Oct. 1985). |
Wigler et al., "Transformation of Mammalian Cells with Genes from Procaryotes and Eucaryotes," Cell 16:777-785 (1979). |
Williams, A. F. and Barclay, A. N.,"The Immunoglobulin Superfamily-Domains for Cell Surface Recognition1,2 ", Ann. Rev. Immunol. 6:381-405 (1988). |
Williams, A. F., "A Year in the Life of the Immunoglobulin Superfamily", Immunology Today 8(10):298-303 (1987). |
Winther et al., "Sites of Rhinovirus Recovery After Point Inoculation of the Upper Airway", JAMA 256(13):1763-1767 (1986). |
Woods et al., "In Vitro and In Vivo Activities of WIN 54954, a New Broad Spectrum Antipicornavirus Drug", Antimicrob. Agents Chemother 33:2069-2074 (1989). |
Zettlmeissl et al., "Expression and Characterization of Human CD4: Immunoglobulin Fusion Proteins," DNA and Cell Biology 9: 347-353 (1990). |
Cited By (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6326004B1 (en) | 1988-09-01 | 2001-12-04 | Bayer Corporation | Antiviral methods using fragments of human rhinovirus receptor (ICAM-1) |
US6514936B1 (en) | 1988-09-01 | 2003-02-04 | Bayer Corporation | Antiviral methods using human rhinovirus receptor (ICAM-1) |
US7132395B1 (en) | 1988-09-01 | 2006-11-07 | Bayer Pharmaceuticals Corporation | Antiviral methods using human rhinovirus receptor (ICAM-1) |
US6867203B2 (en) | 1998-12-29 | 2005-03-15 | Abbott Laboratories | Cell adhesion-inhibiting antiinflammatory and immune-suppressive compounds |
US20100160254A1 (en) * | 2006-04-04 | 2010-06-24 | Marinomed Biotechnologie Gmbh | Cellulose Sulfate for the Treatment of Rhinovirus Infection |
US20080131454A1 (en) * | 2006-12-05 | 2008-06-05 | Marinomed Biotechnologie Gmbh | Methods and Compositions for the Treatment of Rhinovirus Infections with Carrageenan |
US20100040658A1 (en) * | 2006-12-05 | 2010-02-18 | Marinomed Biotechnologie Gmbh | Antiviral composition and method of use |
US8282969B2 (en) | 2006-12-05 | 2012-10-09 | Marinomed Biotechnologie Gmbh | Antiviral composition and method of use |
US10376537B2 (en) | 2006-12-05 | 2019-08-13 | Marinomed Biotech Ag | Antiviral composition and method of use |
Also Published As
Publication number | Publication date |
---|---|
EP0468257A1 (en) | 1992-01-29 |
ZA915678B (en) | 1992-05-27 |
IE912552A1 (en) | 1992-01-29 |
EP0987329A2 (en) | 2000-03-22 |
DK0468257T3 (en) | 2000-03-27 |
EP0987329A3 (en) | 2004-03-03 |
KR100208847B1 (en) | 1999-07-15 |
EP0468257B1 (en) | 1999-09-01 |
JPH04297499A (en) | 1992-10-21 |
FI913470A0 (en) | 1991-07-18 |
KR930002511A (en) | 1993-02-23 |
GR3031768T3 (en) | 2000-02-29 |
DE69131564D1 (en) | 1999-10-07 |
AU652567B2 (en) | 1994-09-01 |
PT98394A (en) | 1992-06-30 |
FI105687B (en) | 2000-09-29 |
ES2134762T3 (en) | 1999-10-16 |
JP3091527B2 (en) | 2000-09-25 |
ATE184049T1 (en) | 1999-09-15 |
IL98866A0 (en) | 1992-07-15 |
AU8117691A (en) | 1992-01-23 |
PT98394B (en) | 1999-01-29 |
DE69131564T2 (en) | 2000-01-13 |
FI913470A (en) | 1992-01-21 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
US6096862A (en) | Multimeric antiviral agent | |
IE83581B1 (en) | Multimeric form of human rhinovirus receptor protein | |
JP3134874B2 (en) | Use of DNA encoding T cell surface protein T4 and T4 fragment for AIDS treatment | |
US5686581A (en) | Multimeric form of human rhinovirus receptor protein | |
US5976877A (en) | Proteins produced by human lymphocytes DNA sequence encoding these proteins and their pharmaceutical and biological uses | |
JP2003089654A (en) | Cd2-binding domain of lymphocyte function associated antigen 3 | |
NO326967B1 (en) | Tumor necrosis factor-related ligand (TRELL), recombinant DNA encoding TRELL, pharmaceutical compositions containing them, and antibody specifically reactive with TRELL | |
US5652210A (en) | Soluble splice variant of the Fas (APO-1) antigen, FasΔTM | |
Martin et al. | Determination of the role for CD21 during Epstein-Barr virus infection of B-lymphoblastoid cells | |
US5871733A (en) | Multimeric forms of human rhinovirus receptor protein | |
US6326004B1 (en) | Antiviral methods using fragments of human rhinovirus receptor (ICAM-1) | |
US6090575A (en) | Polynucleotides encoding human G-protein coupled receptor GPR1 | |
US5972702A (en) | Osteoclast transporter | |
JP2001509663A (en) | Human tumor necrosis factor receptor-like gene | |
US6051385A (en) | Compositions and methods for identifying and testing therapeutics against HSV infection | |
US6107461A (en) | Multimeric forms of human rhinovirus receptor and fragments thereof, and method of use | |
AU675441B2 (en) | Multimeric forms of human rhinovirus receptor protein | |
WO1998033819A9 (en) | Cellular receptors for subgroup c adenoviruses and group b coxsackieviruses | |
US6143298A (en) | Soluble truncated forms of ICAM-1 | |
CA2384115C (en) | Methods and compositions for treatment of inflammatory disease using cadherin-11 modulating agents | |
US5928890A (en) | Human amine receptor | |
WO1995004756A1 (en) | Complement inhibitor proteins of non-human primates | |
AU2004212622C1 (en) | A Tumor Necrosis Factor Related Ligand | |
EP1472288B1 (en) | Viral cd30 polypeptide | |
AU710965B2 (en) | Multimeric forms of human rhinovirus receptor protein |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
STCF | Information on status: patent grant |
Free format text: PATENTED CASE |
|
AS | Assignment |
Owner name: BAYER CORPORATION, PENNSYLVANIA Free format text: MERGER AND CHANGE OF NAME;ASSIGNOR:MILES INC.;REEL/FRAME:014154/0135 Effective date: 19950401 Owner name: BAYER PHARMACEUTICALS CORPORATION, CONNECTICUT Free format text: ASSIGNMENT OF ASSIGNORS INTEREST;ASSIGNOR:BAYER CORPORATION;REEL/FRAME:014154/0178 Effective date: 20030530 Owner name: MILES, INC., PENNSYLVANIA Free format text: MERGER;ASSIGNOR:MOLECULAR THERAPEUTICS, INC.;REEL/FRAME:014154/0183 Effective date: 19920115 |
|
FEPP | Fee payment procedure |
Free format text: PAYOR NUMBER ASSIGNED (ORIGINAL EVENT CODE: ASPN); ENTITY STATUS OF PATENT OWNER: LARGE ENTITY |
|
FPAY | Fee payment |
Year of fee payment: 4 |
|
FPAY | Fee payment |
Year of fee payment: 8 |
|
REMI | Maintenance fee reminder mailed | ||
AS | Assignment |
Owner name: BAYER HEALTHCARE LLC, NEW YORK Free format text: ASSIGNMENT OF ASSIGNORS INTEREST;ASSIGNOR:BAYER PHARMACEUTICALS CORPORATION;REEL/FRAME:023027/0804 Effective date: 20071219 Owner name: BAYER HEALTHCARE LLC,NEW YORK Free format text: ASSIGNMENT OF ASSIGNORS INTEREST;ASSIGNOR:BAYER PHARMACEUTICALS CORPORATION;REEL/FRAME:023027/0804 Effective date: 20071219 |
|
FPAY | Fee payment |
Year of fee payment: 12 |