US6354603B1 - Sealing device for carpule - Google Patents

Sealing device for carpule Download PDF

Info

Publication number
US6354603B1
US6354603B1 US09/486,874 US48687400A US6354603B1 US 6354603 B1 US6354603 B1 US 6354603B1 US 48687400 A US48687400 A US 48687400A US 6354603 B1 US6354603 B1 US 6354603B1
Authority
US
United States
Prior art keywords
needle
cartridge
opening
membrane
top end
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
US09/486,874
Inventor
Alain Villette
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Individual
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Application granted granted Critical
Publication of US6354603B1 publication Critical patent/US6354603B1/en
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Images

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/24—Ampoule syringes, i.e. syringes with needle for use in combination with replaceable ampoules or carpules, e.g. automatic
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/31—Details
    • A61M2005/3103—Leak prevention means for distal end of syringes, i.e. syringe end for mounting a needle
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S215/00—Bottles and jars
    • Y10S215/03—Medical

Definitions

  • the present invention relates to a sealing device intended particularly, but not exclusively, for carpules or injection cartridges, in particular those containing anesthetics.
  • cartridges for mounting on a syringe, are constituted by a small tube, generally made of glass having an end wall that constitutes a moving piston for expelling liquid into a hollow needle.
  • a small tube generally made of glass having an end wall that constitutes a moving piston for expelling liquid into a hollow needle.
  • the front portion of the cartridge Prior to the needle being inserted, the front portion of the cartridge is closed by a rubber capsule or seal membrane disk through which the needle is to pass, the seal membrane being secured to the tube by means of a metal ring crimped over the seal membrane and onto the front of the tube.
  • Such a structure provides acceptable sealing during storage and transport of cartridges, with pressure being in balance on either side of the membrane.
  • pressure being applied to the end of the cartridge, once a needle has been mounted on the cartridge, then a leak occurs between the seal membrane disk and the metal ring. This leak takes place at the periphery of the rubber membrane and the metal ring.
  • the pressure applied to the end of the carpule is transmitted by the liquid which tends to lift the membrane disk off the seat constituted by the front portion of the tube, thus allowing the liquid to pass between the seat and the rear wall of the membrane.
  • AU-A-603 862 describes a crown that serves to center the rubber membrane.
  • the object of the invention is to mitigate the drawbacks mentioned above even when high pressure is applied, and to make injections possible without leaks, even when high pressures are necessary, e.g., for intradiploic, intraligamentary, intraseptal, intrapalatine, etc. injections. It is based on the idea that to provide sealing under high pressure it is necessary to compress a flexible membrane between the edges of two non-deformable parts.
  • the link part between the needle and the front portion of the cartridge presents a projecting crown of diameter substantially equal to the diameter of the opening in the cartridge, and preferably slightly smaller than opening in the cartridge, that comes to bear against the flexible membrane so as to press it against the inside edge of the top surface of the cartridge.
  • connection part between the needle and the cartridge can either be an adapter for mounting the needle on a syringe or needle carrier, or else an overmolded plastic part that surrounds the needle proper.
  • the needle carrier integrated in the front portion by molding can have the same disposition.
  • FIG. 1 is a view of the top portion of a prior art cartridge
  • FIG. 2 is a view showing how the membrane is deformed in an injector of the invention.
  • FIG. 3 is a view of a needle of the invention.
  • FIG. 1 shows the top of a conventional type of glass cartridge 1 , e.g., containing anesthetic.
  • FIG. 2 shows the top of a glass cartridge 1 according to the invention.
  • the cartridge 1 has a flat top surface 2 against which there rests a flexible membrane 3 of rubber, neoprene, or the like.
  • the membrane 3 is held against the surface 2 by a metal ring 5 whose bottom portion is crimped in a groove 4 of the cartridge 1 (see also FIG. 2 ).
  • the top central orifice 6 of the cartridge 1 is thus closed by the membrane 3 .
  • the hollow needle (not shown in FIG. 1) passes through the membrane to take the liquid to the injection point.
  • the present invention seeks to establish a leakproof connection in the vicinity of the inner edge 7 of the top surface 2 of the cartridge around the orifice 6 .
  • the needle is mounted in a needle carrier like the needle carrier 8 shown in FIG. 2 .
  • the needle is inserted in the needle carrier 8 to which it is generally screwed via a thread 16 and the needle carrier is slid onto the front of the syringe where it is held by friction. Sliding the needle carrier into place causes a protruding rear end of the needle to pass through the membrane 3 .
  • Reference 10 in FIG. 2 designates the passage followed by the needle proper.
  • the bottom skirt 11 of the needle carrier preferably has indentations 12 that facilitate sliding of the needle carrier over the carpule and provide an effective mechanical connection.
  • the needle carrier 8 has a projecting crown 9 of diameter nearly equal to the diameter of the orifice 6 of the cartridge 1 as shown in FIG. 3, or slightly smaller than the diameter of orifice 6 as shown in FIG. 2 .
  • the crown has a height that is equal to 1 . 5 millimeters, for example.
  • this sealing crown 9 bears against a same-sized zone of the membrane 3 so that prior to injection the membrane takes up the shape shown in the figure. That is to say the central portion of the membrane 3 takes up the shape of a biconvex lens.
  • This deformation presses the membrane against the inside edge 7 of the cartridge 1 and against a ring around the inside of the top surface 2 , defining orifice 6 . This produces a sealing zone that opposes any leakage.
  • the needle is mounted on the carpule by means of a needle carrier 8 .
  • the needle proper is usually surrounded by an overmolded plastics part enabling it to be fixed in the needle carrier without there being any need to touch it with the hand.
  • the present invention can also be implemented when the needle is mounted directly on the carpule.
  • One such needle is shown in FIG. 3 . It comprises a hollow metal channel 13 on which a plastic part 14 is overmolded.
  • the assembly part 14 has a frustoconical front end and a slightly conical bottom skirt 15 which is provided with indentations 12 enabling the skirt 15 to slide over the outside wall of the cartridge 1 .
  • the skirt is not fitted with an inside thread as used in the preceding embodiment to secure the needle to the thread 16 of the needle carrier 8 .
  • the part 14 has a sealing crown 9 which performs the same function as in the preceding embodiment.

Abstract

A device for sealing a syringe in which a cartridge is inserted, the cartridge being closed at its top end by a flexible membrane and being connected to an injection needle of a needle-carrier part presenting a crown between the needle and the top surface of the cartridge so as to bear against the membrane to press the membrane inwardly just inside the edge of the orifice in the top surface of the cartridge and sealing the membrane to the top surface along the edge.

Description

The present invention relates to a sealing device intended particularly, but not exclusively, for carpules or injection cartridges, in particular those containing anesthetics.
BACKGROUND OF THE INVENTION
These cartridges, for mounting on a syringe, are constituted by a small tube, generally made of glass having an end wall that constitutes a moving piston for expelling liquid into a hollow needle. Prior to the needle being inserted, the front portion of the cartridge is closed by a rubber capsule or seal membrane disk through which the needle is to pass, the seal membrane being secured to the tube by means of a metal ring crimped over the seal membrane and onto the front of the tube.
Such a structure provides acceptable sealing during storage and transport of cartridges, with pressure being in balance on either side of the membrane. However, it is frequently observed that when pressure is applied to the end of the cartridge, once a needle has been mounted on the cartridge, then a leak occurs between the seal membrane disk and the metal ring. This leak takes place at the periphery of the rubber membrane and the metal ring. The pressure applied to the end of the carpule is transmitted by the liquid which tends to lift the membrane disk off the seat constituted by the front portion of the tube, thus allowing the liquid to pass between the seat and the rear wall of the membrane.
Proposals have already been made to improve the sealing of cartridges provided with sealing means so as to ensure that the content remains sterile.
AU-A-603 862 describes a crown that serves to center the rubber membrane.
In U.S. Pat. No. 1,993 629, a collar deforms a block of rubber that closes the front of the glass tube.
In U.S. Pat. No. 2 157 503, a collar has an acute-angled section, but neither its function nor its dimensional relationships with the tube are defined.
Those three documents relate to the hand-operated syringes, i.e. acting under relatively low pressure.
OBJECT AND SUMMARY OF THE INVENTION
The object of the invention is to mitigate the drawbacks mentioned above even when high pressure is applied, and to make injections possible without leaks, even when high pressures are necessary, e.g., for intradiploic, intraligamentary, intraseptal, intrapalatine, etc. injections. It is based on the idea that to provide sealing under high pressure it is necessary to compress a flexible membrane between the edges of two non-deformable parts.
According to the invention, in the device for sealing a syringe in which there is inserted a cartridge that is closed at its top end by a flexible membrane and that is connected to an injection needle, the link part between the needle and the front portion of the cartridge presents a projecting crown of diameter substantially equal to the diameter of the opening in the cartridge, and preferably slightly smaller than opening in the cartridge, that comes to bear against the flexible membrane so as to press it against the inside edge of the top surface of the cartridge.
Thus, when pressure is applied to the end wall of the carpule, the crown presses the disk strongly against the top edge of the opening, thereby deforming it and preventing any leakage. The connection part between the needle and the cartridge can either be an adapter for mounting the needle on a syringe or needle carrier, or else an overmolded plastic part that surrounds the needle proper. With some syringes, the needle carrier integrated in the front portion by molding can have the same disposition.
BRIEF DESCRIPTION OF THE DRAWINGS
Other characteristics and advantages of the invention will appear on reading the following description of particular embodiments, given purely by way of non-limiting example and with reference to the drawings, in which:
FIG. 1 is a view of the top portion of a prior art cartridge;
FIG. 2 is a view showing how the membrane is deformed in an injector of the invention; and
FIG. 3 is a view of a needle of the invention.
MORE DETAILED DESCRIPTION
FIG. 1 shows the top of a conventional type of glass cartridge 1, e.g., containing anesthetic. FIG. 2 shows the top of a glass cartridge 1 according to the invention. The cartridge 1 has a flat top surface 2 against which there rests a flexible membrane 3 of rubber, neoprene, or the like. The membrane 3 is held against the surface 2 by a metal ring 5 whose bottom portion is crimped in a groove 4 of the cartridge 1 (see also FIG. 2). As shown in FIG. 1, the top central orifice 6 of the cartridge 1 is thus closed by the membrane 3. The hollow needle (not shown in FIG. 1) passes through the membrane to take the liquid to the injection point.
When pressure is applied to the lower end wall of the cartridge (not shown) while the needle is in place, the top wall of the membrane presses firmly against the inside surface of the crimped metal ring 5, thereby tending to lift the membrane off the seat constituted by the top surface 2 of the cartridge and thus giving rise to leaks. The present invention seeks to establish a leakproof connection in the vicinity of the inner edge 7 of the top surface 2 of the cartridge around the orifice 6.
In numerous syringes, the needle is mounted in a needle carrier like the needle carrier 8 shown in FIG. 2. The needle is inserted in the needle carrier 8 to which it is generally screwed via a thread 16 and the needle carrier is slid onto the front of the syringe where it is held by friction. Sliding the needle carrier into place causes a protruding rear end of the needle to pass through the membrane 3. Reference 10 in FIG. 2 designates the passage followed by the needle proper. The bottom skirt 11 of the needle carrier preferably has indentations 12 that facilitate sliding of the needle carrier over the carpule and provide an effective mechanical connection.
In accordance with the invention, beneath the channel 10, the needle carrier 8 has a projecting crown 9 of diameter nearly equal to the diameter of the orifice 6 of the cartridge 1 as shown in FIG. 3, or slightly smaller than the diameter of orifice 6 as shown in FIG. 2. The crown has a height that is equal to 1.5 millimeters, for example. As can be seen in FIG. 2, this sealing crown 9 bears against a same-sized zone of the membrane 3 so that prior to injection the membrane takes up the shape shown in the figure. That is to say the central portion of the membrane 3 takes up the shape of a biconvex lens. This deformation presses the membrane against the inside edge 7 of the cartridge 1 and against a ring around the inside of the top surface 2, defining orifice 6. This produces a sealing zone that opposes any leakage.
In the above embodiment, the needle is mounted on the carpule by means of a needle carrier 8. The needle proper is usually surrounded by an overmolded plastics part enabling it to be fixed in the needle carrier without there being any need to touch it with the hand. The present invention can also be implemented when the needle is mounted directly on the carpule. One such needle is shown in FIG. 3. It comprises a hollow metal channel 13 on which a plastic part 14 is overmolded. The assembly part 14 has a frustoconical front end and a slightly conical bottom skirt 15 which is provided with indentations 12 enabling the skirt 15 to slide over the outside wall of the cartridge 1. Unlike known needles, the skirt is not fitted with an inside thread as used in the preceding embodiment to secure the needle to the thread 16 of the needle carrier 8. However, the part 14 has a sealing crown 9 which performs the same function as in the preceding embodiment.
Naturally, numerous variants can be provided, in particular by substituting equivalent technical means, without thereby going beyond the ambit of the invention.

Claims (4)

What is claimed is:
1. A syringe, comprising:
a cartridge for a liquid having a top end with a circular opening and a back end, the back end receiving a piston and the top end being closed over an edge of the circular opening by a flat flexible membrane maintained against the top end of the cartridge by a metal ring, said top end being connected to an injection needle borne by said syringe and linked to said cartridge,
further comprising a projecting crown formed above the opening of said top end and projecting toward the opening in the top end of the cartridge, the crown having a diameter that is slightly smaller than a diameter around the edge of the opening, the crown bearing against said membrane to press the membrane against the edge of the opening.
2. A syringe according to claim 1, the needle being inserted in an overmolded plastic having a duct for passing the needle portion, wherein the crown is formed inside the said portion beneath the duct for passing the needle.
3. A syringe according to claim 2, wherein the said overmolded plastic portion comprises a skirt that fits around the top end of the cartridge.
4. A syringe containing a cartridge for a liquid, said cartridge having a top end and a back end, the top end having a circular central opening at which a flat flexible membrane is held by a ring around the central opening and through which part of the needle is passed, the needle being borne by a needle carrier, a projecting crown being formed on an inside and at the center of the needle carrier around the opening the crown having a diameter that is slightly smaller than a diameter around the edge of the opening, the crown bearing against said membrane to press the membrane against the edge of the opening.
US09/486,874 1998-03-07 1999-02-07 Sealing device for carpule Expired - Fee Related US6354603B1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
FR9808503A FR2780653B1 (en) 1998-07-03 1998-07-03 SEALING DEVICE FOR A CARPULE
FR9808503 1998-07-03
PCT/FR1999/001588 WO2000001430A2 (en) 1998-07-03 1999-07-02 Sealing device for capsule, in particular for injection capsules or cartridges

Publications (1)

Publication Number Publication Date
US6354603B1 true US6354603B1 (en) 2002-03-12

Family

ID=9528208

Family Applications (1)

Application Number Title Priority Date Filing Date
US09/486,874 Expired - Fee Related US6354603B1 (en) 1998-03-07 1999-02-07 Sealing device for carpule

Country Status (5)

Country Link
US (1) US6354603B1 (en)
EP (1) EP1047463A2 (en)
JP (1) JP2002519157A (en)
FR (1) FR2780653B1 (en)
WO (1) WO2000001430A2 (en)

Cited By (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20030036742A1 (en) * 2001-08-17 2003-02-20 Becton, Dickinson And Company Liquid specimen collection system
US20090171311A1 (en) * 2007-12-28 2009-07-02 Aktivpak, Inc. Dispenser and therapeutic package suitable for administering a therapeutic substance to a subject, along with method relating to same
US20100179473A1 (en) * 2006-12-29 2010-07-15 Amir Genosar Hypodermic drug delivery reservoir and apparatus
US9468423B2 (en) 2012-01-10 2016-10-18 Becton, Dickinson And Company Safety shield for fluid specimen container
US9504816B2 (en) 2008-03-17 2016-11-29 Syringetech Llc Multi-mode syringe
CN114258311A (en) * 2019-07-26 2022-03-29 卢昱來 Medicine injection cartridge and medicine injector comprising same

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP3999489B2 (en) * 2001-10-19 2007-10-31 住友ゴム工業株式会社 Syringe
CA2777146A1 (en) * 2009-10-16 2011-04-21 Sanofi-Aventis Deutschland Gmbh Arrangement for use in a drug delivery device
DK2654848T3 (en) * 2010-12-21 2016-05-30 Sanofi Aventis Deutschland PATTERN HOLDER DEVICE FOR A PHARMACEUTICAL SUPPLY DEVICE

Citations (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US1993629A (en) 1932-02-09 1935-03-05 Arthur E Smith Syringe and ampule therefor
US2157503A (en) 1936-04-10 1939-05-09 Arthur E Smith Ampoule syringe
US2870766A (en) * 1956-06-06 1959-01-27 American Home Prod Cartridge for metering syringe
US3084688A (en) * 1959-07-15 1963-04-09 Robert K Mcconnaughey Disposable hypodermic syringe
US3387609A (en) * 1966-01-19 1968-06-11 Walter A. Shields Closure cap for disposable hypodermic syringes
US3710794A (en) * 1971-06-16 1973-01-16 W Shields Recessed diaphragm with annular grooves for hypodermic syringes
US3976069A (en) * 1974-04-08 1976-08-24 U.S. Philips Corporation Injection syringe with cartridge retaining tab
US3995630A (en) * 1974-09-12 1976-12-07 U.S. Philips Corporation Injection syringe with telescopic assembly between cartridge and vial
US4568346A (en) * 1982-10-27 1986-02-04 Duphar International Research, B.V. Hypodermic syringe having a telescopic assembly between cartridge and medicament holder
US4909794A (en) * 1988-06-24 1990-03-20 Habley Medical Technology Corporation Combination retractable needle cannula and cannula lock for a medication carpule
US4935014A (en) * 1988-06-24 1990-06-19 Habley Medical Technology Corporation Combination retractable needle cannual and cannual lock for a medication carpule
AU603862B2 (en) 1988-02-10 1990-11-29 Astra Pharmaceuticals Pty Ltd Plastic cartridge and syringe
US4982769A (en) * 1990-02-21 1991-01-08 Survival Technology, Inc. Package
US5067945A (en) * 1988-03-01 1991-11-26 Ryan Medical, Inc. Safety needled medical devices capable of one-handed manipulation
US5085332A (en) * 1991-04-11 1992-02-04 Gettig Technologies, Inc. Closure assembly
US5188599A (en) * 1989-07-11 1993-02-23 Med-Design, Inc. Retractable needle system
US5316163A (en) * 1992-08-24 1994-05-31 Pohl Gmbh & Co. Kg Bottle top having inner and outer caps for securing and sealing a resilient stopper
US5334162A (en) * 1993-03-15 1994-08-02 Eli Lilly And Company Cartridge assembly for a lyophilized compound forming a disposable portion of an injector pen and method for same
US5421469A (en) * 1993-03-02 1995-06-06 Morihiro Sudo Synthetic resin sealing cap for a fluid bottle
US5611786A (en) * 1993-07-09 1997-03-18 Disetronic Ag Needle system fastening mechanism
US5662230A (en) * 1990-07-13 1997-09-02 J. G. Finneran Associates Crimp top seal for vials
US5709668A (en) * 1991-01-16 1998-01-20 Senetek Plc Automatic medicament injector employing non-coring needle
US5718690A (en) * 1996-06-10 1998-02-17 Gettig Technologies, Incorporated Hypodermic injector system and method for maintaining the sterility thereof prior to use
US6017331A (en) * 1998-02-20 2000-01-25 Becton Dickinson And Company Threaded medication cartridge

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5067947A (en) * 1989-07-18 1991-11-26 Tri/West Systems, Inc. Syringe plunger rod mount
DE19751219A1 (en) * 1997-11-19 1999-05-27 Vetter & Co Apotheker Syringe, especially prefilled syringe, or carpule

Patent Citations (25)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US1993629A (en) 1932-02-09 1935-03-05 Arthur E Smith Syringe and ampule therefor
US2157503A (en) 1936-04-10 1939-05-09 Arthur E Smith Ampoule syringe
US2870766A (en) * 1956-06-06 1959-01-27 American Home Prod Cartridge for metering syringe
US3084688A (en) * 1959-07-15 1963-04-09 Robert K Mcconnaughey Disposable hypodermic syringe
US3387609A (en) * 1966-01-19 1968-06-11 Walter A. Shields Closure cap for disposable hypodermic syringes
US3710794A (en) * 1971-06-16 1973-01-16 W Shields Recessed diaphragm with annular grooves for hypodermic syringes
US3976069A (en) * 1974-04-08 1976-08-24 U.S. Philips Corporation Injection syringe with cartridge retaining tab
US3995630A (en) * 1974-09-12 1976-12-07 U.S. Philips Corporation Injection syringe with telescopic assembly between cartridge and vial
US4568346A (en) * 1982-10-27 1986-02-04 Duphar International Research, B.V. Hypodermic syringe having a telescopic assembly between cartridge and medicament holder
AU603862B2 (en) 1988-02-10 1990-11-29 Astra Pharmaceuticals Pty Ltd Plastic cartridge and syringe
US5067945A (en) * 1988-03-01 1991-11-26 Ryan Medical, Inc. Safety needled medical devices capable of one-handed manipulation
US4909794A (en) * 1988-06-24 1990-03-20 Habley Medical Technology Corporation Combination retractable needle cannula and cannula lock for a medication carpule
US4935014A (en) * 1988-06-24 1990-06-19 Habley Medical Technology Corporation Combination retractable needle cannual and cannual lock for a medication carpule
US5188599A (en) * 1989-07-11 1993-02-23 Med-Design, Inc. Retractable needle system
US4982769A (en) * 1990-02-21 1991-01-08 Survival Technology, Inc. Package
US5662230A (en) * 1990-07-13 1997-09-02 J. G. Finneran Associates Crimp top seal for vials
US5709668A (en) * 1991-01-16 1998-01-20 Senetek Plc Automatic medicament injector employing non-coring needle
US5085332A (en) * 1991-04-11 1992-02-04 Gettig Technologies, Inc. Closure assembly
US5085332B1 (en) * 1991-04-11 1994-04-05 Gettig Technologies Inc Closure assembly
US5316163A (en) * 1992-08-24 1994-05-31 Pohl Gmbh & Co. Kg Bottle top having inner and outer caps for securing and sealing a resilient stopper
US5421469A (en) * 1993-03-02 1995-06-06 Morihiro Sudo Synthetic resin sealing cap for a fluid bottle
US5334162A (en) * 1993-03-15 1994-08-02 Eli Lilly And Company Cartridge assembly for a lyophilized compound forming a disposable portion of an injector pen and method for same
US5611786A (en) * 1993-07-09 1997-03-18 Disetronic Ag Needle system fastening mechanism
US5718690A (en) * 1996-06-10 1998-02-17 Gettig Technologies, Incorporated Hypodermic injector system and method for maintaining the sterility thereof prior to use
US6017331A (en) * 1998-02-20 2000-01-25 Becton Dickinson And Company Threaded medication cartridge

Cited By (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20030036742A1 (en) * 2001-08-17 2003-02-20 Becton, Dickinson And Company Liquid specimen collection system
US6921395B2 (en) * 2001-08-17 2005-07-26 Becton, Dickinson And Company Liquid specimen collection system
US20100179473A1 (en) * 2006-12-29 2010-07-15 Amir Genosar Hypodermic drug delivery reservoir and apparatus
US8684968B2 (en) 2006-12-29 2014-04-01 Aktivpak, Inc. Hypodermic drug delivery reservoir and apparatus
US20090171311A1 (en) * 2007-12-28 2009-07-02 Aktivpak, Inc. Dispenser and therapeutic package suitable for administering a therapeutic substance to a subject, along with method relating to same
US8663188B2 (en) 2007-12-28 2014-03-04 Aktivpak, Inc. Dispenser and therapeutic package suitable for administering a therapeutic substance to a subject, along with method relating to same
US9504816B2 (en) 2008-03-17 2016-11-29 Syringetech Llc Multi-mode syringe
US9468423B2 (en) 2012-01-10 2016-10-18 Becton, Dickinson And Company Safety shield for fluid specimen container
CN114258311A (en) * 2019-07-26 2022-03-29 卢昱來 Medicine injection cartridge and medicine injector comprising same

Also Published As

Publication number Publication date
FR2780653B1 (en) 2000-10-20
EP1047463A2 (en) 2000-11-02
WO2000001430A2 (en) 2000-01-13
WO2000001430A3 (en) 2000-08-10
FR2780653A1 (en) 2000-01-07
JP2002519157A (en) 2002-07-02

Similar Documents

Publication Publication Date Title
US4781701A (en) Syringe for medical purposes
US7846146B2 (en) Medicament cartridge
US6027482A (en) Syringe tip cap
US5275582A (en) Disposable syringe
US6126644A (en) Holder for a syringe and an injection device using the holder
US5858008A (en) Cannula sealing shield assembly
US6189580B1 (en) Vial transferset and method
US6520935B1 (en) Syringe and tip cap assembly
US6354603B1 (en) Sealing device for carpule
US8534477B2 (en) Closure system for containers
CA1098405A (en) Nose cap and diaphragm assembly for injector
US20070260189A1 (en) Syringe with Recessed Nose for Use with Frontal Attachments
AU2006312731A1 (en) Cylinder/piston unit having a non-cylindrical chamber
US5799829A (en) Membrane-sealed tube with a needle closure
US7014766B2 (en) Self-venting filter element for a fuel filter arrangement
JPS6224104B2 (en)
US4809888A (en) Metering valve
EP0022576A1 (en) Syringe with inner cone
US5165573A (en) Adhesive container
CN217793985U (en) Injection assembly and injection device
US6004058A (en) Marking instrument
EP0837779B1 (en) Marking instrument
KR820001166Y1 (en) Injector for infusion
JP2597985Y2 (en) Ejector
CN115320279A (en) Ink filling bottle

Legal Events

Date Code Title Description
REMI Maintenance fee reminder mailed
LAPS Lapse for failure to pay maintenance fees
STCH Information on status: patent discontinuation

Free format text: PATENT EXPIRED DUE TO NONPAYMENT OF MAINTENANCE FEES UNDER 37 CFR 1.362

FP Lapsed due to failure to pay maintenance fee

Effective date: 20060312