US6558400B2 - Obesity treatment tools and methods - Google Patents

Obesity treatment tools and methods Download PDF

Info

Publication number
US6558400B2
US6558400B2 US09/871,297 US87129701A US6558400B2 US 6558400 B2 US6558400 B2 US 6558400B2 US 87129701 A US87129701 A US 87129701A US 6558400 B2 US6558400 B2 US 6558400B2
Authority
US
United States
Prior art keywords
area
stomach
tissue
interior
adhering member
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
US09/871,297
Other versions
US20020183768A1 (en
Inventor
Mark E. Deem
Douglas S. Sutton
Hanson S. Gifford, III
Bernard H. Andreas
Ronald G. French
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Ethicon Endo Surgery Inc
Original Assignee
Satiety Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Satiety Inc filed Critical Satiety Inc
Priority to US09/871,297 priority Critical patent/US6558400B2/en
Assigned to SATIETY, INC. reassignment SATIETY, INC. ASSIGNMENT OF ASSIGNORS INTEREST (SEE DOCUMENT FOR DETAILS). Assignors: ANDREAS, BERNARD H., FRENCH, RONALD G., SUTTON, DOUGLAS S., DEEM, MARK E., GIFFORD, HANSON S. III
Priority to US10/155,362 priority patent/US7083629B2/en
Priority to AT02739531T priority patent/ATE424790T1/en
Priority to AU2002312174A priority patent/AU2002312174B2/en
Priority to PCT/US2002/017077 priority patent/WO2002096327A2/en
Priority to EP02739531A priority patent/EP1389984B1/en
Priority to ES02739531T priority patent/ES2321487T3/en
Priority to MXPA03010987A priority patent/MXPA03010987A/en
Priority to BRPI0210900-0A priority patent/BR0210900B1/en
Priority to DE60231489T priority patent/DE60231489D1/en
Priority to JP2002592844A priority patent/JP4283546B2/en
Priority to CA002448961A priority patent/CA2448961A1/en
Priority to US10/313,394 priority patent/US7288099B2/en
Publication of US20020183768A1 publication Critical patent/US20020183768A1/en
Priority to US10/342,623 priority patent/US7288101B2/en
Priority to US10/402,061 priority patent/US7503922B2/en
Application granted granted Critical
Publication of US6558400B2 publication Critical patent/US6558400B2/en
Priority to NO20035239A priority patent/NO20035239D0/en
Priority to US10/729,552 priority patent/US8613749B2/en
Priority to US10/729,622 priority patent/US7510559B2/en
Priority to JP2005156465A priority patent/JP4268599B2/en
Priority to US11/364,036 priority patent/US7306614B2/en
Priority to AU2006230695A priority patent/AU2006230695B2/en
Priority to US11/654,783 priority patent/US7862574B2/en
Priority to US11/654,709 priority patent/US7909838B2/en
Priority to US11/716,902 priority patent/US8075577B2/en
Priority to US11/801,474 priority patent/US8137367B2/en
Priority to US11/801,475 priority patent/US8080025B2/en
Priority to US11/801,449 priority patent/US8137366B2/en
Priority to US11/801,450 priority patent/US8080022B2/en
Priority to US11/757,943 priority patent/US8123765B2/en
Priority to JP2008284886A priority patent/JP2009078158A/en
Priority to US13/029,075 priority patent/US8419755B2/en
Assigned to ETHICON ENDO-SURGERY, INC. reassignment ETHICON ENDO-SURGERY, INC. ASSIGNMENT OF ASSIGNORS INTEREST (SEE DOCUMENT FOR DETAILS). Assignors: SATIETY, INC.
Priority to US13/847,040 priority patent/US8794243B2/en
Priority to JP2013087257A priority patent/JP5524387B2/en
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Images

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00Surgical instruments, devices or methods, e.g. tourniquets
    • A61B17/11Surgical instruments, devices or methods, e.g. tourniquets for performing anastomosis; Buttons for anastomosis
    • A61B17/1114Surgical instruments, devices or methods, e.g. tourniquets for performing anastomosis; Buttons for anastomosis of the digestive tract, e.g. bowels or oesophagus
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00Surgical instruments, devices or methods, e.g. tourniquets
    • A61B17/064Surgical staples, i.e. penetrating the tissue
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61FFILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F5/00Orthopaedic methods or devices for non-surgical treatment of bones or joints; Nursing devices; Anti-rape devices
    • A61F5/0003Apparatus for the treatment of obesity; Anti-eating devices
    • A61F5/0013Implantable devices or invasive measures
    • A61F5/0083Reducing the size of the stomach, e.g. gastroplasty
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61FFILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F5/00Orthopaedic methods or devices for non-surgical treatment of bones or joints; Nursing devices; Anti-rape devices
    • A61F5/0003Apparatus for the treatment of obesity; Anti-eating devices
    • A61F5/0013Implantable devices or invasive measures
    • A61F5/0083Reducing the size of the stomach, e.g. gastroplasty
    • A61F5/0086Reducing the size of the stomach, e.g. gastroplasty using clamps, folding means or the like
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00Surgical instruments, devices or methods, e.g. tourniquets
    • A61B17/00234Surgical instruments, devices or methods, e.g. tourniquets for minimally invasive surgery
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00Surgical instruments, devices or methods, e.g. tourniquets
    • A61B17/064Surgical staples, i.e. penetrating the tissue
    • A61B17/0644Surgical staples, i.e. penetrating the tissue penetrating the tissue, deformable to closed position
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00Surgical instruments, devices or methods, e.g. tourniquets
    • A61B17/12Surgical instruments, devices or methods, e.g. tourniquets for ligaturing or otherwise compressing tubular parts of the body, e.g. blood vessels, umbilical cord
    • A61B17/122Clamps or clips, e.g. for the umbilical cord
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00Surgical instruments, devices or methods, e.g. tourniquets
    • A61B2017/00535Surgical instruments, devices or methods, e.g. tourniquets pneumatically or hydraulically operated
    • A61B2017/00557Surgical instruments, devices or methods, e.g. tourniquets pneumatically or hydraulically operated inflatable
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00Surgical instruments, devices or methods, e.g. tourniquets
    • A61B17/30Surgical pincettes without pivotal connections
    • A61B2017/306Surgical pincettes without pivotal connections holding by means of suction
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B90/00Instruments, implements or accessories specially adapted for surgery or diagnosis and not covered by any of the groups A61B1/00 - A61B50/00, e.g. for luxation treatment or for protecting wound edges
    • A61B90/39Markers, e.g. radio-opaque or breast lesions markers
    • A61B2090/3937Visible markers
    • A61B2090/395Visible markers with marking agent for marking skin or other tissue

Definitions

  • the present invention relates generally to tools and methods for the treatment of obesity. More particularly, the present invention relates to tools and methods for performing less traumatic gastroplasty procedures.
  • Obesity is considered a major health problem with annual associated costs reaching $100 billion in the U.S. alone.
  • Morbid obesity is a condition of obesity with the presence of a secondary debilitating progressive disease and is generally associated with a body mass index (BMI) ⁇ 40 kg/m 2 .
  • BMI body mass index
  • the basic mechanism of obesity is simply an imbalance between caloric intake and burn rate, the underlying factors are varied and complex and conservative attempts at sustained weight loss with this population are almost always unsuccessful.
  • obesity is a disease that eludes a simple treatment, with a recurrence rate above 90% for those who attempt to lose weight.
  • Surgical procedures for obesity date back to 1889 (Billroth) with the earliest peer reviewed procedure being the jejuno-ileal bypass in 1954 (Kreman).
  • a successful procedure is commonly defined as one that results in at least 50% excess weight loss at 2 years.
  • Today, the most commonly done operation is the Roux-en-Y gastric bypass (RYGB), with around 35,000 performed annually in the U.S.
  • Other forms of bariatric surgery include Fobi pouch, bilio-pancreatic diversion, and gastroplasty or “stomach stapling”.
  • the single existing procedure that involves an implanted device is the Lap-Band, which is a laparoscopically installed inflatable cuff that is placed around the top of the stomach just below the lower esophageal sphincter (LES). This device affects satiety only (no reduced caloric absorption). Because there is more to obesity than simple overeating, it is unlikely that Lap-Band by itself will ever be as effective as a surgery that includes other
  • the RYGB procedure is a procedure which has become very common in bariatric surgery. This procedure facilitates the movement of the jejunum to a high position by using a retrocolic Roux-en-Y loop.
  • the procedure is generally performed through a 6-8 inch incision extending from the end of the breastbone to just above the navel.
  • the stomach is completely divided into 2 unequal portions (a smaller upper and a larger lower gastric pouch) using an automatic stapling device with the raw surface reinforced with additional sutures.
  • the upper pouch typically measures less than about 1 ounce or 20 cc, while the lower larger pouch remains generally intact and continues to secrete stomach juices flowing through the intestinal tract.
  • a segment of the small intestine (just distal of the duodenum or proximal of the jejunum) is then brought from the lower abdomen and joined with the upper pouch to form an end-to-end anastomosis created through a half-inch opening, also called the stoma.
  • This segment of the small intestine is called the “Roux loop” and carries food from the upper pouch to the remainder of the intestines, where the food is digested.
  • the remaining lower pouch and the attached segment of duodenum are then reconnected to form another anastomotic connection to the Roux loop at a location approximately 50-150 cm (1.6-4.9 ft) from the stoma, typically using a stapling instrument.
  • GSD gastroesophageal reflux disease
  • the lower esophageal sphincter is located in a distal portion of the esophagus adjacent to the junction between the esophagus and the stomach.
  • GERD gastroesophageal reflux disease
  • GERD is a disorder where the esophageal sphincter allows the stomach contents, which includes gastric acid and bile, to flow back into the distal portion of the esophagus.
  • Some complications associated with GERD include heartburn, pulmonary disorders, chest pain, esophageal ulcers, esophagitis, Barrett's esophagus, and esophageal carcinoma.
  • GERD GERD-associated GERD
  • Surgical procedures have included a procedure called the Nissen fundoplication, where a portion of the gastric fundus is wrapped around the esophagus. The wrapped fundus applies pressure to the esophagus to limit the reverse flow of the stomach contents. Effectively elongating the esophagus by fundoplication or by extending it via a staple line may be done to treat GERD.
  • Conventional fundoplication procedures may be effective at treating GERD, but they also have disadvantages. For instance, many of these procedures require large incisions to be made in a patient.
  • Laparoscopic procedures typically require several smaller incisions formed in the abdominal wall for the insertion of instruments into the patient's body.
  • such procedures can be expensive and they can increase the risks of post-operative hernias, accidental organ perforations, and other related drawbacks.
  • U.S. Pat. No. 5,549,621 to Bessler et al. which is incorporated herein by reference in its entirety, pertains to an apparatus and method for performing vertical banded gastroplasty without the use of staples.
  • the described device uses at least two clamping bars to create a tubular-shaped pouch. However, the device is deployed laparoscopically onto the external surface of the stomach.
  • U.S. Pat. No. 5,345,949 to Shlain which is incorporated herein by reference in its entirety, relates to laparoscopic methods and tools for inserting a banding device to bring the walls of the stomach adjacent to one another between the proximal pouch and the distal region of the stomach. But there is no procedure for the creation of an internal pouch internally created from the stomach.
  • U.S. Pat. No. 6,113,609 to Adams which is incorporated herein by reference in its entirety, pertains to a system which includes placement of a distal anchor through a hole formed in the wall of the esophagus and through a hole formed in the gastric wall, which are then fastened together.
  • U.S. Pat. No. 5,571,116 to Bolanos et al. which is incorporated herein by reference in its entirety, pertains to an invagination device which approximates the lower esophagus and the fundus of the stomach.
  • GSD gastroesophageal reflux disease
  • One method involves reducing the size of the stomach pouch to limit the caloric intake as well as to provide an earlier feeling of satiety. This may be done by creating a smaller gastric pouch within the stomach. This procedure optionally may be enhanced by performing a pyloroplasty prior to and/or in conjunction with the pouch size reduction, i.e., rendering the pyloric sphincter incompetent.
  • the food in the stomach may be made to also bypass a proximal portion of the bowel, i.e., a portion of the duodenum and jejunum, by creating a gastric anastomosis thereby creating a malabsorption of sugars and fats which are mostly absorbed in the bypassed portion of the duodenum and jejunum.
  • Sugars and fats entering the bowel directly from the stomach rather than passing through the pylorus and proximal duodenum and jejunum may cause “dumping” syndrome and diarrhea. This in turn may create enforced behavioral modifications, thereby discouraging the patient from eating these types of high-caloric foods.
  • a marking device such as a bougie
  • a marking device may be used at the beginning of the procedure, to create a dye marker “road map” on the interior surface of the stomach from the pylorus to the esophagus.
  • This may enable visualization by, e.g., an endoscope, to give the physician a clear reference point for staple or fixation element placement.
  • a distal balloon which is preferably attached to an inflation tip at a distal end, may be inserted into the pylorus to stabilize the bougie during the procedure and may be inflated from the proximal end of the tubing by the physician.
  • one variation involves grasping the interior walls of the stomach, preferably via an endoscope advanced trans-esophageally, and placing one to several individual fixation elements on opposing interior walls and then bringing those fixation elements together.
  • the stomach pouch may be modified and/or created by a variety of other device variations utilizing other methods, e.g., stapling opposing sides of a stomach together to form two separate lumens from within the interior surface of the stomach.
  • An endoscopic stapling device may be used to accomplish such a task.
  • Such an endoscopic stapler preferably brings two regions of tissue into apposition and may then apply a fastening element, e.g., staples, clips, tags, screws, etc., into the two regions of tissue to affix them together.
  • rotating and rotatable probes may also be used to form a modified smaller lumen within a main lumen.
  • Such probes generally may be inserted into a stomach endoscopically and may engage a portion of the interior lining of the stomach and may then be rotated to roll the engaged portion of the stomach wall around the probe itself to bring the wall in apposition with another portion of the stomach wall.
  • Such rotating probes may be used to create a blind-ended pouch of stomach within the main stomach lumen, or as with the other devices, may be used to create a smaller pouch exiting into the pylorus.
  • a row or a plurality of fasteners e.g., staples, blind staples, clips, tags, adhesives, screws, etc.
  • fasteners e.g., staples, blind staples, clips, tags, adhesives, screws, etc.
  • gastric volume reduction devices as part of the present invention.
  • Such volume reduction devices generally may be inserted into a stomach trans-esophageally through the use of, e.g., an endoscope.
  • the reduction device may be used to draw or engage a portion of the interior lining of the stomach; the drawn or engaged portion may then be eventually removed, either actively or through natural processes, e.g., pressure necrosis.
  • a pyloroplasty procedure may also be performed to enhance treatment.
  • the pyloroplasty may be performed prior to (preferable), in conjunction with, or following the gastric reduction procedure.
  • a pyloroplasty procedure typically results in the pyloric sphincter being rendered incompetent.
  • a pyloroplasty device may be passed endoscopically through the esophagus, into the stomach, and preferably into position in or across the pylorus. Energy or a stimulus is then preferably applied to the pylorus to render it incompetent.
  • an additional anastomosis gastric bypass procedure may also be performed to further enhance treatment.
  • the anastomosis procedure may be performed preferably prior to, in conjunction with, or following the gastric reduction and pyloroplasty procedures (if performed at all).
  • the procedure generally involves endoscopically or laparoscopically creating a side-to-side anastomosis preferably from within the stomach and bowel and within the digestive tract. This procedure may be similar to the Roux-en-Y gastric bypass procedure but with minimal trauma.
  • FIG. 1A shows an example of a modified stomach having a smaller pouch created from the interior surface lining.
  • FIG. 1B shows a partial superior view of the cross section from FIG. 1 A.
  • FIG. 2 shows a variation on a marking device or bougie for marking the interior surface of a stomach.
  • FIG. 3A shows a variation on positioning a marking device inserted into a stomach.
  • FIG. 3B shows a cross section view from FIG. 3A of a deflated stomach around the marking device.
  • FIG. 3C shows the cross section view from FIG. 3B of an insufflated stomach with the resulting marks.
  • FIG. 4A shows a view of the interior of the lesser curvature of a stomach with anchors attached.
  • FIG. 4B shows a cross section view from FIG. 4A with the anchors attached.
  • FIG. 5A shows a side view of a crimping variation on a fastening device.
  • FIGS. 5B and 5C show a superior and side view, respectively, of several interlocked crimping devices from FIG. 5 A.
  • FIG. 6A shows an isometric view of a zip-tie or ratcheted variation on a fastening device.
  • FIG. 6B shows a superior view of the device of FIG. 6A attached to the stomach wall.
  • FIG. 6C shows a superior view of another double zip-tie variation on a fastening device.
  • FIG. 6D shows the stomach of FIG. 6B with the fasteners cinched.
  • FIG. 6E shows a superior view of another perpendicular zip-tie variation on a fastening device.
  • FIGS. 7A and 7B show a superior view of an extendable double hook device attaching to a stomach wall.
  • FIG. 7C shows the device of FIG. 7A locked by a crimping variation.
  • FIGS. 8A and 8B show a superior view of a modified stomach maintained by a fastening staple.
  • FIGS. 9A and 9B show isometric views of a variation on an endoscopic stapling device.
  • FIG. 10 shows an isometric view of a variation on a box stapling device.
  • FIG. 11A shows an assembly view of another stapling device variation.
  • FIG. 11B shows a side view of the device of FIG. 11 A.
  • FIG. 12A shows an isometric view of a crescent shaped variation of a stapling device.
  • FIG. 12B shows an end view of the device of FIG. 12A showing a staple deploying.
  • FIG. 12C shows an interior side view of the device of FIG. 12A with a translating wedge sequentially deploying staples.
  • FIG. 13 shows an interior view of a stomach with an example of stapling device placement.
  • FIG. 14 shows an interior view of a stomach with an example of a modified stapling device which may be used for the treatment of GERD.
  • FIG. 15A shows an assembly view of a variation on an approximating device.
  • FIGS. 15B to 15 D show the process of invaginating stomach interior lining and fastening using the device of FIG. 15 A.
  • FIGS. 15E shows the assembly view of another variation of the device of FIG. 15A wherein the clip may be replaced by a screw.
  • FIGS. 15F to 15 H show the process of invaginating stomach interior lining and fastening using the device of FIG. 15 E.
  • FIG. 16A shows an example of a modified stomach created by a rotating device variation.
  • FIG. 16B shows a superior cross section view of the stomach of FIG. 16A where the modified lumen may be created by rotating the interior stomach lining upon itself.
  • FIG. 16C shows an alternate superior cross section view of the stomach of FIG. 16A where the modified lumen may be created by rotating apposed portions of the interior stomach lining upon itself.
  • FIGS. 17A and 17B show an isometric and cross section view, respectively, of a vacuum tube variation.
  • FIGS. 18A and 18B show an isometric and cross section view, respectively, of a counter-rotating vacuum tube variation.
  • FIGS. 19A and 19B show an isometric and cross section view, respectively, of a vacuum tube variation with attachment points.
  • FIGS. 20A and 20B show an isometric and cross section view, respectively, of a split tube variation.
  • FIG. 21 shows an example of placement within a stomach of a rotatable device variation.
  • FIGS. 22A and 22B show the possible creation of a rotated lumen using the device of FIGS. 19A and 19B.
  • FIGS. 23A to 23 D show the possible creation of a rotated lumen using the device of FIGS. 20A and 20B.
  • FIG. 24A shows an isometric view of a variation on a dual rotatable tube device.
  • FIGS. 24B and 24C show an end view and cross section view, respectively, of the device of FIG. 24 A.
  • FIG. 25A shows a variation on an endoscopic vacuum device in a stomach.
  • FIGS. 25B and 25C show an end view of a variation on lumen creation from the interior surface of the stomach using the device of FIG. 25 A.
  • FIG. 26 shows an isometric view of a variation on a gastric volume reduction device.
  • FIGS. 27A to 27 D show the device of FIG. 26 inserted into a stomach to draw or cinch up lining tissue to reduce a volume of the stomach.
  • FIG. 28 shows another variation on a gastric volume reduction device utilizing a grasping device and a ligating device.
  • FIGS. 29A and 29B show an isometric view on a variation of a gastric volume reduction device utilizing tractive rollers to draw tissue up between them.
  • FIG. 29C shows another variation of the device of FIGS. 29A and 29B with ratcheted rollers.
  • FIG. 30 shows an isometric view of a variation on a pyloroplasty device with an angioplasty balloon.
  • FIG. 31 shows an isometric view of another variation on a pyloroplasty device with extendable probes.
  • FIGS. 32A and 32B show variations on sphincterotome arms for use in a pyloroplasty procedure.
  • FIG. 33 shows a stomach with a distal portion of the wall of the lesser curvature removed to show a possible use for the device of FIG. 31 .
  • FIG. 34A shows an isometric view of another variation on a pyloroplasty device with a combination cutting and stapling notch.
  • FIG. 34B shows the device of FIG. 34A in a possible use in a stomach.
  • FIG. 35 shows a representative and normal gastro-intestinal system of a person.
  • FIG. 36 shows an example of a gastro-intestinal system modified by a preferable anastomosis procedure.
  • FIG. 37 shows an isometric view of a variation on an anastomosis deployment device.
  • FIG. 38 shows a cross section view of an anastomosis assembly mating a portion of the stomach with a portion of the intestinal tract.
  • FIG. 39 shows a cross section view of another anastomosis assembly mating two different portions of the intestinal tract.
  • the size of the stomach pouch may be reduced to limit the caloric intake as well as to provide an earlier feeling of satiety. This may be accomplished by creating a smaller gastric pouch within the stomach by a variety of methods. This procedure optionally may be enhanced by performing a pyloroplasty prior to and/or in conjunction with the pouch size reduction, i.e., rendering the pyloric sphincter incompetent.
  • the food in the stomach may be made to also bypass a proximal portion of the bowel, i.e., a portion of the duodenum and jejunum, by creating a gastric anastomosis thereby creating a malabsorption of sugars and fats which are mostly absorbed in the bypassed portion of the duodenum and jejunum.
  • Sugars and fats entering the bowel directly from the stomach rather than passing through the pylorus and proximal duodenum and jejunum may cause “dumping” syndrome and diarrhea.
  • rendering the pylorus incompetent may also lead to dumping syndrome partly because of the rapid gastric emptying which may occur. This in turn may create enforced behavioral modifications, thereby discouraging the patient from eating these types of high-caloric foods.
  • FIG. 1A shows an example of a modified stomach 10 which may be created, by any one of the methods described below, as part of the present invention. Greater curvature 12 and lesser curvature 14 is seen in modified stomach 10 , as well as the distal end of esophagus 16 and pylorus 18 . As part of the present invention, stomach 10 may be divided along junction 24 into modified pouch 22 , which is preferably less than about 1 ounce in volume, and main pouch 20 .
  • FIG. 1B shows a partial superior view of the cross section of main pouch 20 and modified pouch 22 as viewed from cutting plane P from FIG. 1 A. As seen, modified lumen 26 is preferably formed by junction 24 from main lumen 28 by joining a portion of stomach wall 30 .
  • modified pouch 22 accepts food from esophagus 16 and preferably passes it directly through modified lumen 26 into pylorus 18 .
  • Main pouch 20 may remain intact and function normally, but preferably sees little or no food. Acids and other fluids that may be generated in main lumen 28 may drain through the reduced outlet near pylorus 18 and may pass through the digestive system normally.
  • a marking device may be used, preferably at the beginning of the procedure, to create a dye marker “road map” on the interior surface of the stomach from the pylorus to the esophagus. Once such dye marks are placed, they may be visualized, e.g., endoscopically, thereby giving the physician a clear reference point for staple or fixation element placement.
  • An example of such a marking device is shown in FIG. 2 as marking device or bougie 40 .
  • Bougie 40 is preferably an elongated device made from tubing member 44 which may have several channels defined within.
  • Tubing 44 may be made from any variety of biocompatible materials, e.g., stainless steel, plastics, etc., and preferably has a diameter and cross section which is similar to that of the finished modified lesser pouch.
  • a series of dye ports 46 through which the marking dye may be channeled through from the proximal end of bougie 40 .
  • biocompatible dyes which preferably enhance visualization may be used, e.g., methylene blue, thionine, acridine orange, acridine yellow, acriflavine, quinacrine and its derivatives, brilliant green, gentian violet, crystal violet, triphenyl methane, bis naphthalene, trypan blue, and trypan red.
  • a distal balloon 52 which may be inserted into the pylorus to stabilize bougie 40 during the procedure, is preferably attached to inflation tip 50 at distal end 42 and may be inflated from the proximal end of tubing 44 by the physician.
  • FIGS. 3A to 3 C show bougie 40 during one method of use.
  • FIG. 3A shows stomach 60 as bougie 40 is inserted down through esophagus 62 .
  • distal balloon 52 may be inflated through inflation tip 50 , thus securing the device.
  • Bougie 40 preferably follows lesser curvature 64 and may alternatively be shaped to approximate lesser curvature 64 .
  • Bougie 40 is also preferably rotated such that dye ports 46 face away from lesser curvature 64 and face towards greater curvature 66 .
  • FIG. 3B shows cross section 3 B— 3 B from FIG. 3A as deflated stomach 60 .
  • modified lumen 70 may take shape around bougie 40 , separate from deflated main lumen 68 .
  • the dye may be channeled through dye ports 46 , thereby leaving dye marks 72 on interior lining 74 .
  • lumen 68 may be insufflated, as shown in FIG. 3C, and bougie 40 may then be removed.
  • dye marks 72 mark or delineate the junction region where anchors or fasteners may be placed to draw interior lining 74 together to form the modified lumen.
  • One variation of reducing the stomach size involves grasping the interior walls of the stomach, preferably via an endoscope advanced trans-esophageally, and placing one to several fixation elements on opposing interior walls and then bringing those fixation elements together.
  • FIG. 4A shows a view of the interior of the lesser curvature of stomach 60 with part of the greater curvature wall removed.
  • individual anchors 80 may be secured to the interior surface along the junction 24 where modified pouch 22 from FIG. 1A would form.
  • Anchors 80 may be of any biocompatible material, e.g., stainless steel, polymers, etc., which may be formed into a variety of fasteners, e.g., staples, ratcheted wires, zip ties, clips, tags, eyelets, crimps, and screws.
  • Anchors 80 may be placed by estimating the junction boundary, but they are preferably located along dye mark 72 , which may be formed by methods and tools described above, prior to anchor 80 placement, as shown in FIG.
  • suture 82 may be drawn through each of the anchors 80 , preferably in a zig-zag manner, and then suture 82 may be drawn tight to bring the opposing surfaces of interior lining 74 together in apposition along dye marks 72 to form the modified lumen.
  • individual anchors 80 may be preloaded or prefastened by suture 82 , and anchors 80 may be fastened to interior lining 74 in this manner.
  • FIG. 5A shows a side view of a variation on a fastening device in crimping member 90 .
  • Crimping member 90 is preferably made from a biocompatible material, e.g., stainless steel, nitinol, etc., and may be formed to have elbow 92 extend into two opposing anchoring ends 94 .
  • FIG. 5B shows a superior view of a created modified lumen 100 formed from main lumen 98 by any of the methods described herein.
  • several crimping members 90 may be attached or fastened to interior lining 96 by anchoring ends 94 . As they become attached, each of the members 90 are preferably configured to interlock with an adjacent crimping member 90 , much like a zipper.
  • FIG. 5B shows the interlocked members 90 from the top to form lumen 100
  • FIG. 5C shows the view from 5 C— 5 C from FIG. 5B where each of the crimping members 90 are shown interlocking at their elbows 92 like a zipper.
  • FIG. 6A shows an isometric view of another variation on a fastening device in ratcheted wire or zip tie 110 .
  • This particular variation shows a distal tip or male end 112 and a corresponding proximal end or female end 114 , with ratcheted length 116 between those two ends.
  • FIG. 6B shows a superior view of stomach wall 120 just prior to the formation of modified lumen 124 from main lumen 122 .
  • male end 112 of first zip tie 110 ′ may be pierced through one side of interior lining 118 and second zip tie 110 ′′ may be pierced through the opposing side of interior lining 118 such that the male ends 112 of each zip tie preferably correspond to the female ends 114 of the other zip tie.
  • each zip tie 110 ′, 110 ′′ may be drawn together and tightened accordingly, as shown in FIG. 6D.
  • a plurality of zip ties 110 are preferably used to form modified lumen 124 by aligning them by any of the methods described above.
  • An alternative zip tie device which may be used is a perpendicular type version of zip tie 110 .
  • first perpendicular zip tie 134 ′ and second perpendicular zip tie 134 ′′ may be used in place of zip tie 110 and lumen 124 may be formed in much the same manner as described above to result in the modified stomach as shown in FIG. 6E.
  • a further alternative is shown in FIG. 6C where male zip tie 126 preferably has dual piercing male ends with catcher tubes 128 .
  • a vacuum-type device as described below in detail, or forceps may be used to draw portions of stomach wall 120 in apposition.
  • needles 130 which are preferably passed through a double female zip tip 132 , may be used to pierce through tissue 120 and lock into catcher tubes 128 . Needles 130 may then be drawn back through tissue 120 , while simultaneously pulling male ends/catcher tubes 128 back through tissue 120 and into the corresponding double female zip tie 132 . The locked zip tie 126 may then be drawn tight against female zip tie 132 , trimmed, and then released. This procedure may be repeated for any number of zip ties which may be used to draw the stomach lining together to form the smaller pouch and may also be used with the dye marking device 40 and procedure as described above.
  • FIG. 7 A shows gasping device 140 with retaining tube 142 and extendable members 146 which may extend from distal opening 144 .
  • Extendable members 146 are preferably made from a biocompatible material, e.g., superelastic or shape memory alloy such as nitinol, which may be biased to urge away from a longitudinal axis defined by tube 142 once extended beyond distal opening 144 .
  • members 146 may reach out to grasp apposed portions of interior lining 150 by hooks 148 .
  • the locations where hooks 148 grasp may be defined by the marking device as described above and viewed by the physician through, e.g., an endoscope.
  • members 146 may then be drawn back through distal opening 144 , as shown in FIG. 7B, and a retaining device, such as crimp 152 , may be slid over a distal section of members 146 , as shown in FIG. 7C, to maintain the position of hooks 148 and apposed lining 150 to create the desired lumen.
  • a retaining device such as crimp 152
  • FIG. 8A shows the cross sectioned superior view of FIG. 1B with the addition of staple 160 maintaining junction 24 .
  • the figure shows an example of how, e.g., an endoscopically applied stapler, may be used to retain and hold junction 24 to form modified lumen 26 .
  • FIG. 8B shows a close-up view of the junction 24 and staple 160 which was applied from within lumen 26 .
  • an endoscopic stapling device may be used to accomplish such a task.
  • Such an endoscopic stapler preferably brings two regions of tissue into apposition and may then apply a fastening element, e.g., staples, clips, tags, etc., into the two regions of tissue to affix them together.
  • a fastening element e.g., staples, clips, tags, etc.
  • These stapling devices may optionally incorporate the use of the marking device or bougie 40 , as described above, as a preliminary step as a guide to vacuum placement and/or stapling to form the desired modified lumen.
  • the fastening elements e.g., staples
  • the fastening elements are preferably made of a biocompatible material such as stainless steel, titanium, polymers, sutures, nitinol, or any other similar metals and alloys, etc. and may be in any conventional shape such as C-shaped and U-shaped staples or any of the other shapes as described herein.
  • the two regions of tissue may be adhered to the stapling device by a variety of attachment methods, e.g., tines, barbs, hooks, vacuum, or any combinations thereof.
  • such a device may be a tubular or wand-shaped member and preferably has at least two windows which may be spaced about the circumference of the tube or wand. These windows may be separated by an arc in a range of about 20° to 180° about the longitudinal axis defined by the length of the tube or wand, and are preferably separated by an arc in a range of about 90° to 180°.
  • FIG. 9A shows a variation of an endoscopic stapling device in the isometric view of anvil stapling device 170 .
  • Stapling unit 172 is shown attached to the distal end of tube 174 .
  • staple enclosure 176 Within stapling unit 172 is staple enclosure 176 where staples may be loaded and vacuum ports 178 which are seen in an alternating fashion with staple slots 180 , through which the staples may be deployed.
  • FIG. 9B shows a reverse isometric view of the device of FIG. 9 A.
  • stapling unit 172 may have septum 184 insertable into septum slot 186 , which is preferably midway between the sides of staple enclosure 176 and which may separate the interior of staple enclosure 176 into two separate chambers.
  • Septum 184 may serve several functions, one of which may be to allow selective activation of opposing sides of vacuum ports 178 of unit 172 as tissue is selectively adhered to the device. Other functions of septum 184 are discussed below.
  • stapling unit 172 may be inserted trans-esophageally into a stomach and a first portion of the interior lining may be adhered to a single side of staple enclosure 176 through a vacuum created within vacuum ports 178 .
  • the vacuum may be created in stapling unit 172 through tube 174 and activated from the proximal end of tube 174 from outside the patient's body.
  • the opposite set of vacuum ports 178 may be activated and unit 172 may be used to draw the first portion to an opposing second portion of the interior lining, which may then be adhered to the device such that the first portion and the second portion are preferably in apposition to each other.
  • septum 184 may be withdrawn from septum slot 186 by introduced forceps through, e.g., an endoscopic or through an integral actuator, to form a single chamber within staple enclosure 176 . Removal of septum 184 may then bring the first and second portions of tissue into contact apposition.
  • the side surfaces 188 of septum 184 may incorporate a cutting, abrading, scoring, heating, freezing, chemically damaging, or some other damaging surface to tissue. Such a surface 188 may damage the interior lining contacting each other upon removal of septum 184 as surface 188 slides past. This damage may encourage a more vigorous healing response and a more permanent fixation between the damaged tissue once stapled or affixed together.
  • the staples loaded within staple enclosure 176 may be fired through staple slots 180 to affix the tissue.
  • anvil 182 may be used as an anvil to secure the staples to the tissue, thereby resulting in the modified lumen 26 as shown in FIG. 8 B.
  • the length of stapling device 170 may be made according to the desired junction length and the size of the patient's stomach. This particular variation may be withdrawn from the area after the stapling procedure by first pushing the stapling device 170 past the resulting staple line.
  • FIG. 10 shows an isometric view of another variation in box stapling device 190 .
  • Stapling unit 192 is shown as being attached in fluid communication to vacuum tube 193 .
  • Stapling device 190 may be inserted and operated in the same manner as device 170 described above.
  • Stapling unit 192 may have vacuum ports 194 activated selectively on either side of septum 196 as described above.
  • the tips of staples 198 are shown partially deployed for illustration purposes, but are preferably not deployed until septum 196 is first retracted preferably in the direction as indicated.
  • Septum 196 may also be configured to damage the contacting tissue upon septum 196 withdrawal in the same manner as described above.
  • Stapling device 190 may be easily applied and removed after staples 198 have been deployed.
  • FIG. 11A shows an assembly isometric view of another variation in stapling device 200 .
  • This variation 200 shows curved tube 202 which may have lumen 204 house staples 206 as well as act as a combination vacuum and staple slot 216 .
  • Tube 202 may be shaped in a variety of ways but is shown here as a C-shaped or U-shaped tube with first channel 210 ′ and second channel 210 ′′, for adhering the two apposed portions of tissue, preferably separated by removable septum 212 .
  • tissue may be adhered within the channels 210 ′, 210 ′′ through vacuum/staple slot 216 and once positioned, staples 206 may be deployed while septum 212 is removed simultaneously by the use of curved wedge 218 .
  • curved wedge 218 may be drawn within lumen 204 from the tube 202 distal end to the proximal end by, e.g., a pull-wire attached to wedge 218 .
  • wedge 218 would preferably force pivot 208 of staple 206 against contact edge 214 of septum 212 .
  • urging end 220 may then urge the curved ends of staple 206 to rotate about pivot 208 and deploy through slot 216 .
  • notch 222 preferably located at a distal end of wedge 218 , may engage contact edge 214 and begin to slide septum 212 simultaneously towards the proximal end of tube 202 .
  • FIG. 11B shows a side view of stapling device 200 of FIG. 11 A.
  • curved wedge 218 preferably contacts septum 212 via notch 222 and pushes while simultaneously urging staple 206 to deploy.
  • the figures show a single staple 206 for illustrative purposes only and any plurality of staples 206 may be used in practice depending upon the desired results.
  • FIG. 12A shows an isometric view of yet another variation in stapling device 230 .
  • This variation may omit a removable septum.
  • Curved tube 232 is preferably curved in this variation in a crescent shape forming contact channel 234 .
  • a number of vacuum ports 236 and staple slots 238 may be defined in an alternating pattern, as shown.
  • a possible W-shaped staple 240 preferably having pivot 242 at the staple 240 midpoint is shown outside of tube 232 for illustrative purposes in a possible orientation for insertion within staple slots 238 .
  • FIG. 12B shows cross section 12 B— 12 B from FIG. 12 A.
  • tube 232 defines lumen 244 , which preferably runs the length of tube 232 , and translating wedge 246 which is preferably slidingly disposed within lumen 244 .
  • wedge 246 may be translated by pull-wire 248 .
  • Pull-wire 248 which may be made of any high-strength material, e.g., stainless steel, nitinol, nylon, polymers, etc., may be manipulated by a physician from the proximal end of tube 232 from outside of the patient's body.
  • any high-strength material e.g., stainless steel, nitinol, nylon, polymers, etc.
  • translating wedge 246 may be advanced proximally. Advancing wedge 246 may urge staples 240 to deploy through staple slots 238 sequentially as shown to hold the tissue and form the desired lumen.
  • FIG. 13 An example of deployment for any of the stapling devices described above is shown in FIG. 13 .
  • stomach 250 with the wall partially cut out is seen with stapling device 252 inserted within.
  • Stapling device 252 is shown merely as an example of insertion and could comprise any of the devices described herein.
  • Device 252 which is preferably advanced trans-orally into stomach 250 and through esophagus 256 , is preferably located at the distal end of delivery/vacuum tube 254 . Once inserted, device 252 may be located by the assistance of the lesser curvature 258 of stomach 250 .
  • vacuum/staple ports 260 which may be any of the configurations as described herein.
  • stapling device 252 may be configured to produce a staple line or junction following the lesser curvature beginning from cardiac notch 264 down towards pylorus 262 . Accordingly, device 252 may have the length and vacuum/staple ports 260 configured such that the distal end of device 252 points towards pylorus 262 .
  • FIG. 14 shows stapling device 270 in a slightly different configuration for the treatment of other gastrointestinal diseases such as gastroesophageal reflux disease (GERD), as discussed above.
  • the stomach 250 of FIG. 13 is shown, but for the treatment of GERD, stapling device 270 may be slightly modified such that the device 270 and vacuum/staple ports 272 may be straight or flared away from, rather than towards, lesser curvature 258 and pylorus 262 as described above.
  • vacuum/staple ports 272 would preferably produce a staple line or junction beginning from cardiac notch 264 and then flares away from lesser curvature 258 and pylorus 262 .
  • Device 270 may be any of the devices described and operated herein, but for the flared modification.
  • any of the devices described herein may be used for the treatment of GERD by simply angling the device to produce a flared staple line.
  • a simple non-flared staple line may also suffice for treating GERD.
  • the staple line may act as a Heimlich valve which preferably closes down in response to pressure exerted from the greater or main lumen.
  • the smaller volume of the modified lumen in-line with esophagus 256 may provide a smaller volume of acid available for esophageal reflux.
  • Tube 282 is preferably a tubular device which may be inserted into a stomach through the esophagus of a patient.
  • a lumen 284 may run through tube 282 from a proximal end to the distal end of tube 282 .
  • two or more windows or slots 286 are preferably defined opposite of one another, as shown.
  • the lengths and widths of slots 286 may vary and is preferably long enough to approximate the desired length of the boundary or junction line of the modified lumen; likewise, the width is preferably wide enough to accommodate at least two layers of the stomach interior lining.
  • Approximating clip 288 is shown having at least two piercing ends 290 and may be loaded into tube lumen 284 from either the proximal end or distal end of tube 282 preferably prior to inserting the device 280 into the patient.
  • Clip 288 is preferably made of a biocompatible material as described above.
  • Biodegradable plug 292 may be placed into the distal end of tube 282 prior to insertion into the patient and is preferably made of a biocompatible biodegradable material, e.g., biodegradable polymers such as polylactide, polyglycolide, and their copolymers.
  • Plug 292 may be alternatively made from a non-biodegradable material and may simply pass after the procedure. Plug 292 may aid in maintaining a vacuum seal through slots 286 during the approximation procedure, as described below.
  • FIG. 15B shows an end view from section 15 B— 15 B from FIG. 15A of tube 282 in operation.
  • opposing portions of stomach interior lining 294 may be drawn into lumen 284 through opposing slots 286 by creating a vacuum within lumen 284 .
  • Approximating clip 288 may be urged distally through tube 282 such that each of ends 290 may be drawn through a corresponding slot 286 over and/or pierced through lining 294 within lumen 284 .
  • biodegradable plug 292 may become invaginated within lining 294 .
  • tube 282 may be withdrawn from the area while clip 288 preferably slides through the distal end of tube 282 leaving the approximated interior lining 294 held in position by ends 290 , as seen in FIG. 15 D. Removal of tube 282 may urge plug 292 to slide off the distal end of tube 282 and remain within the newly formed lumen to become degraded over time or to pass through the patient's system.
  • FIG. 15E shows the device of FIG. 15A, but in this variation, clip 288 may be replaced by screw 289 , which is preferably in the shape of a helix or coil having a tapering width or diameter.
  • the first few turns or coils of screw 289 may have the same or similar diameter than the remaining tapering coils; this may enable piercing end 291 to engage interior 294 and may also allow screw 289 to be advanced at the desired orientation through the tissue.
  • Screw 289 preferably maintains a parallel orientation with tube 282 during delivery into the tissue, i.e., a longitudinal axis defined by screw 289 is preferably parallel, or close to parallel, with the longitudinal axis defined by tube 282 .
  • the outer diameter of the first few turns or coils are preferably the same diameter, or slightly less than, the inner diameter of tube 282 . This may further enable screw 289 to be advanced through lumen 284 at the proper orientation prior to engaging interior 294 .
  • opposing portions of stomach interior lining 294 may be drawn into lumen 284 through opposing slots 286 by creating a vacuum within lumen 284 , as shown in FIG. 15 F.
  • Screw 289 may then be urged through lumen 284 and rotated in the direction of the arrow shown until piercing end 291 engages the invaginated lining 294 .
  • Piercing end 291 preferably is sharp and needle-like to enable piercing through multiple layers of lining 294 . As screw 289 is further rotated, it may be further advanced distally through the remaining portion of invaginated lining 294 .
  • the tapering diameter and decreasing width may also begin to further approximate the opposing edges of lining 294 towards one another, as shown in FIG. 15 G.
  • further advancement of screw 289 preferably draws the opposing surfaces into contact with one another.
  • Tube 282 may then be removed, as described above.
  • Screw 289 may be made of a bioabsorbable or biocompatible material, as described herein such as a polymer or superelastic alloy, and may be integrally formed with barbs or whisker-like filaments protruding along its length to help prevent screw 289 from backing out once it has been engaged within the lining 294 .
  • a spiraling suturing needle or screw which may be used in this variation is shown and described in U.S. Pat. No. 5,330,503 to Yoon, which is incorporated herein by reference in its entirety.
  • Another example of a helical fastener or screw and applicator which may be used in this or another variation is shown and described in U.S. Pat. No.
  • rotating and rotatable probes may also be used to form a modified smaller lumen within a main lumen.
  • Such probes generally may be inserted into a stomach endoscopically and may engage a portion of the interior lining of the stomach and may then be rotated to roll the engaged portion of the stomach wall around the probe itself to bring the wall in apposition with another portion of the stomach wall.
  • Such rotating probes may be used to create a blind-ended pouch of stomach within the main stomach lumen, or as with the other devices, may be used to create a smaller pouch exiting into the pylorus.
  • a row or a plurality of fasteners e.g., staples, blind staples, clips, tags, adhesives, etc.
  • the tubes themselves may be made of any variety of biocompatible materials which preferably have sufficient strength to undergo a torsional load, e.g., stainless steel, nickel, platinum, etc.
  • FIG. 16 A An example of a stomach modified by such a rotating probe or device is shown in FIG. 16 A.
  • Main pouch 300 is seen with modified pouch 302 formed along the lesser curvature of the stomach and delineated by junction 304 .
  • modified pouch 302 extending from esophagus 306 and terminating in pouch opening 308 proximally of pylorus 310 .
  • Pouch opening 308 may also be made to terminate at pylorus 310 .
  • FIG. 16B shows a superior view from cross section 16 B— 16 B from FIG. 16A of one variation on producing modified pouch 302 having modified lumen 314 from main pouch 300 having main lumen 312 where junction 304 may be formed by rotating the stomach upon itself.
  • FIG. 16C shows an alternative superior view from cross section 16 B— 16 B from FIG. 16A where modified pouch 302 ′ having modified lumen 314 ′ may be formed from main pouch 300 ′ having main lumen 312 ′.
  • junction 304 ′ may be formed by taking apposed sides of the interior stomach lining near the lesser curvature and approximating them to form modified lumen 314 ′.
  • FIG. 17A shows vacuum tube 320 which may have an elongate tubular body.
  • Tube 320 may be inserted into a patient's stomach trans-esophageally via, e.g., an endoscope.
  • distal end 322 is preferably rounded or gently tapered to be atraumatic to the patient.
  • An opening or window 324 may be defined in the wall of tube 320 near distal end 322 and as seen in FIG. 17B, opening 324 is preferably in communication with lumen 326 , which may run throughout tube 320 .
  • the geometry of opening 324 is preferably large enough to accommodate the invagination of tissue from the interior stomach lining by a vacuum created within lumen 326 and opening 324 .
  • the vacuum may be activated by the physician from a proximal end of tube 320 from outside of the patient.
  • a fastening member may be inserted and deployed to secure the interior stomach lining thereby reducing its overall volume, as described in further detail below.
  • tube 320 preferably has a diameter and cross section which may approximate a final geometry of the newly created lumen within the stomach.
  • FIG. 18A shows an isometric view of another variation in counter-rotating tube 330 .
  • Counter-rotating tube 330 may have a gently tapered distal end 332 with an opening 334 defined in the tube wall near distal end 332 .
  • an additional inner tube 336 Preferably contained within tube 330 is an additional inner tube 336 , which may be geometrically similar to tube 330 but with a diameter small enough to allow free rotation about the longitudinal axis preferably shared by both tubes 330 and 336 .
  • Inner tube 336 likewise may have inner opening 338 , which may allow communication between lumen 340 and openings 334 and 338 .
  • a vacuum may be activated from a proximal end of tube 330 to draw tissue from the interior stomach lining through lumen 340 and into openings 334 and 338 when they are aligned.
  • FIG. 18B which is cross section 18 B— 18 B from FIG. 18A
  • inner tube 336 may be rotated to effectively pinch and firmly hold the tissue in place, as shown in FIG. 18 B.
  • the addition of the pinching action in addition to the vacuum may aid in holding the tissue, thereby aiding in the rotation of both tube 330 and inner tube 336 when forming the modified lumen.
  • Both tubes 330 and 336 may be manipulated and rotated from a proximal end of the tubes from outside of the patient.
  • FIG. 19A shows an isometric view of another variation in barbed tube 350 .
  • Tube 350 may be similar to vacuum tube 320 described above.
  • Distal end 352 is preferably tapered and opening 354 may be defined in the wall of tube 350 near distal end 352 .
  • at least one and preferably several attachment points 356 e.g., tines, barbs, or hooks, may be defined along at least a single edge around opening 354 .
  • Attachment points 356 are preferably defined along the leading edge of opening 354 for rotation of tube 350 .
  • FIG. 19B which is cross section 19 B— 19 B from FIG. 19A, shows opening 354 preferably in communication with lumen 358 and a preferred orientation of attachment point 356 .
  • FIG. 20A shows an isometric view of yet another variation in split tube 360 .
  • Split tube 360 may be formed of at least two splittable halves, e.g., first half 364 and second half 366 , which may be joined together longitudinally along split 370 . When first half 364 and second half 366 are joined together, split tube 360 preferably forms a tapered distal end 362 .
  • Split tube 360 may also define a lumen 372 which may run throughout the length of split tube 360 .
  • This variation may also comprise at least one and preferably several attachment points 368 on each of first half 364 and second half 366 .
  • first half 364 may have a row of attachment points 368 preferably aligned along a portion of split 370 and second half 366 may likewise have a row of attachment points 368 juxtaposed and preferably mirroring those located on first half 364 .
  • Attachment points 368 may be of any type described above and the number and positioning of attachment points 368 may depend upon the desired length of the resulting junction formed upon rolling the stomach.
  • FIG. 20B which is cross section 20 B— 20 B from FIG. 20A, shows split 370 and an example of the juxtaposed relationship of attachment points 368 .
  • FIG. 21 shows an example of a rotatable probe device during insertion into stomach 380 .
  • tube 384 may be inserted into stomach 380 via esophagus 382 , preferably endoscopically.
  • Tube 384 may be any of the devices described above and is shown generally as an example of how such devices may be inserted into an organ, e.g., stomach 380 .
  • the engagement may be accomplished by any of the methods described herein, e.g., attachment points partially piercing the stomach lining, a vacuum adhering a portion of the lining, etc.
  • tube 384 may then be rotated to roll the engaged portion of the stomach wall around the probe itself to bring the wall in apposition with another portion of the stomach wall.
  • FIG. 22A shows a variation on partial cross section 22 / 23 — 22 / 23 from FIG. 21 with tube 350 from FIGS. 19A and 19B in a preferred operation.
  • interior lining 390 may be adhered to tube 350 via a vacuum created in opening 354 through lumen 358 and/or via attachment points 356 which may partially pierce lining 390 , as described above.
  • the location for adhering tube 350 may also be determined or aided by the use of marking device 40 , as described above.
  • tube 350 may be rotated about its longitudinal axis, following the arrow as shown, by at least about 180° and preferably at least about 360°.
  • Lining 390 is preferably rotated until the adhered portion contacts a second portion of lining 390 to result in the modified lumen 314 of FIG. 22B, also shown in FIG. 16 B.
  • fasteners may be fired or deployed through opening 354 or via a separate endoscopic stapling device at location 392 to secure and maintain modified lumen 314 .
  • Fasteners may comprise any of the fasteners as described herein, e.g., staples.
  • tube 350 may then be removed.
  • FIG. 16B shows newly created modified pouch 302 with modified lumen 314 and, as seen, interior lining 390 also forms the interior surface defining modified lumen 314 .
  • FIGS. 23A to 23 D show another variation on partial cross section 22 / 23 — 22 / 23 from FIG. 21 with split tube 360 from FIGS. 20A and 20B.
  • Split tube 360 may be inserted into the stomach either as separate halves 364 , 366 individually or as a whole tube which may then be split while in the stomach. Once separated, first half 364 and second half 366 may be engaged to interior lining 390 by attachment points 368 at a slight distance from one another.
  • the separation distance may be determined by the desired resulting size of the lumen. Alternatively, the separation distance may be determined or aided by the use of marking device 40 , as described above.
  • each of free ends 394 of halves 364 , 366 may then be rotated in the direction of the arrow, as shown. Free ends 394 may be configured to simply contact each other or to interlock with each other and rotate about a hinge or pivot.
  • FIGS. 23B and 23C show the progression of lumen formation as attachment points 368 draw around and towards one another.
  • modified lumen 314 ′ may be formed, as also shown in FIG. 16C, to then be secured or maintained preferably by fasteners, e.g., staples, which may be deployed through junction 304 ′.
  • Dual tube device 400 may have at least two elongate members, first member 402 and second member 404 , which may be rotatingly attached to controlling device 406 and may be parallel to each other.
  • the members 402 , 404 are preferably counter-rotating and may be rotated by a rotation control 408 , which is preferably located on controlling device 406 .
  • First member 402 may have first distal end 410 offset slightly from the longitudinal axis of first member 402 by first bend 412 .
  • First opening 414 is also preferably defined in the wall of first member 402 proximally of first distal end 410 .
  • Second member 404 is preferably similar to first member 402 and may have second distal end 416 offset slightly from the longitudinal axis of second member 404 by second bend 418 . Near second distal end 416 , second opening 420 may be defined in the wall of second member 404 .
  • FIG. 24B shows end view 24 B— 24 B from FIG. 24 A. Distal ends 410 , 416 are seen as preferably being parallel and mirror images of one another. Also, the preferable counter-rotating action may be seen by the directional arrows.
  • FIG. 24C shows cross section 24 C— 24 C from FIG. 24 A. As shown, the relationship between first and second opening 414 , 420 , respectively, and first and second lumen 422 , 424 , respectively, may be seen in the figure. Lumens 422 , 424 preferably run through the length of members 402 , 404 , respectively, and are in communication with openings 414 , 420 .
  • a vacuum may be created in openings 414 , 420 through lumens 422 , 424 , respectively, from the controlling device 406 .
  • members 402 , 404 may be inserted trans-esophageally into a patient's stomach.
  • a vacuum may then be created in first and second openings 414 , 420 to engage a portion of the stomach interior lining.
  • a modified pouch may be created from the interior lining in much the same manner as described for FIGS. 23A to 23 D, except the individual counter-rotating members 402 , 404 do not form a split tube.
  • the operation of the vacuum application and counter-rotation may be controlled through controlling device 406 which is preferably located outside the patient's body.
  • FIG. 25A shows yet another variation in vacuum device 432 shown inserted into stomach 430 .
  • Vacuum device 432 may be an endoscopic device inserted trans-esophageally into stomach 430 through esophagus 434 .
  • Device 432 may have vacuum member 438 and at least two grasping members 440 , preferably disposed on either side of vacuum member 438 .
  • vacuum member 438 may be steered towards a desired area of interior lining 442 , as seen in FIG. 25B which is a cross section view of device 432 attached to stomach interior lining 442 .
  • the desirable area of interior lining 442 may be located along greater curvature 436 or alternatively along lesser curvature 444 , depending upon the desired results.
  • a vacuum may be activated in member 438 to draw a portion of interior lining 442 preferably between grasping members 440 .
  • grasping members 440 may be used to pinch and grasp the drawn portion of lining 442 .
  • device 432 may be rotated in the direction of the arrow indicated in FIG. 25C to result in the formation of a modified lumen.
  • grasping members 440 may be locked in place, disengaged from device 432 , and left as an implant.
  • lining 442 may be fastened to maintain the created lumen by any of the methods described herein and grasping members 440 , along with the rest of device 432 , may be removed from stomach 430 .
  • gastric volume reduction devices may also be used as part of the present invention.
  • Such volume reduction devices generally may be inserted into a stomach trans-esophageally through the use of, e.g., an endoscope.
  • the reduction device may be used to draw or engage a portion of the interior lining of the stomach; the drawn or engaged portion may then be eventually removed, either actively or through natural processes.
  • FIG. 26 shows an isometric view of a variation on the gastric volume reduction device in concentric tube device 450 .
  • Device 450 may have inner tube 452 defining lumen 454 , which preferably runs throughout inner tube 452 .
  • Pusher sleeve 456 may be disposed concentrically over inner tube 452 such that pusher sleeve 456 may be allowed to slide freely along inner tube 452 .
  • Pusher sleeve 456 is also preferably disposed over inner tube 452 such that the distal end of inner tube 452 is open to allow ring 458 to be rolled or stretched onto the distal end.
  • Ring 458 is preferably made of an elastic type material which would allow ring 458 to elastically cinch onto inner tube 452 .
  • FIG. 27A shows a view of concentric tube device 450 within stomach 460 preferably inserted through esophagus 462 .
  • the distal end of device 450 may be brought into position near a location of interior surface 464 where tissue may be desirably removed.
  • a vacuum may be actuated within lumen 454 .
  • the vacuum may then draw a portion of withdrawn lining tissue 466 up into lumen 454 , as seen in the cross section of device 450 .
  • pusher sleeve 456 may be pushed or urged distally along inner tube 452 .
  • pusher sleeve 456 may also push or urge elastic ring 458 distally along inner tube 452 until ring 458 is pushed entirely off the distal end of inner tube 452 and onto a portion of lining tissue 466 , as seen in FIG. 27 C.
  • Device 450 may then be removed from stomach 460 after ceasing the vacuum, thereby leaving lining tissue 466 with elastic ring 458 .
  • pressure necrosis may cause lining tissue 466 and ring 458 to simply fall off from the rest of interior surface 464 to be passed normally through the rest of the patient's body.
  • the action of drawing up and removing a portion of interior surface 464 may effectively reduce the overall volume of stomach 460 , thereby reducing the available volume for the ingestion of foods. As such, this procedure may be repeated several times either sequentially or simultaneously until the overall volume of stomach 460 is reduced to a desirable volume depending upon the desired results.
  • FIG. 28 shows another variation on the gastric volume reduction device.
  • an endoscope 474 preferably having grasping device 476 , e.g., biopsy forceps, may be inserted into stomach 472 .
  • a ligating apparatus e.g., ring stapler, zip tie, etc., either as part of endoscope 474 or as a separately introduced ligation device 478 , is preferably also introduced within stomach 472 .
  • Forceps 476 and ligation device 478 may be used in conjunction with one another by, e.g., having forceps 476 grasp withdrawn tissue 480 and then having ligation device 478 tie or ligate tissue 480 .
  • Forceps 476 may then be used to excise and remove withdrawn tissue 480 above ties 482 to reduce the overall stomach volume.
  • An example of a jaw structure which may be utilized is shown and described in U.S. Pat. No. 5,749,893 to Vidal et al., which is incorporated herein by reference in its entirety.
  • ligated withdrawn tissue 480 may be left attached to stomach 470 to be removed naturally by pressure necrosis.
  • Several excisions may be performed in reducing stomach volume from, e.g., stomach 472 (as shown by the dashed lines) down to a final reduced stomach 470 .
  • FIG. 29A shows yet another variation with tractive rollers 490 .
  • This device may have at least two rigid rollers 492 , which are preferably elongated, connected to one another preferably at both ends by, e.g., elastic members 494 .
  • the connection of rollers 492 may create channel 496 therebetween through which tissue may be drawn.
  • FIG. 29B shows rollers 492 with a portion of stomach interior surface 498 being drawn through channel 496 by a grasping device, e.g., forceps 500 .
  • rollers 492 may be maintained within the stomach by, e.g., retaining forceps 502 , which may be used to hold rollers 492 relative to interior surface 498 .
  • Elastic members 494 may pinch rollers 492 together, thereby creating a zone of pressure necrosis in withdrawn interior surface 498 .
  • rollers 492 may contain a ratcheting device within to prevent surface 498 from rolling out back through channel 496 . Once the desired amount of surface 498 has been drawn, it may either be excised or simply left to be removed naturally by necrosis.
  • FIG. 29C shows an alternative variation with ratcheted rollers 504 .
  • Ratcheted rollers 504 may be operated in the same manner as described for rollers 492 but they preferably have a tractive surface to enhance traction between the tissue and the rollers 504 .
  • Torquing device 506 may be used with ratcheted rollers 504 and may be introduced into the stomach endoscopically to mesh with one of rollers 504 for the purpose of causing it to rotate. Moreover, either rollers 492 or ratcheted rollers 504 may be used simply to gather stomach surface tissue to allow for fastening, e.g., suturing, stapling, etc.
  • Creating a smaller gastric pouch within the stomach may be accomplished by a variety of methods, as described above.
  • a pyloroplasty procedure may also be performed to enhance treatment.
  • the pyloroplasty may be performed prior to (preferable), in conjunction with, or following the gastric reduction procedure.
  • a pyloroplasty procedure typically results in the pyloric sphincter being rendered incompetent.
  • the pyloroplasty procedure as described herein may be omitted.
  • Conventional pyloroplasty procedures may typically be performed surgically or through the use of standard peripheral angioplasty balloons, e.g., in the 7 mm range.
  • a more aggressive procedure may be needed.
  • a pyloroplasty device may be passed endoscopically through the esophagus, into the stomach, and preferably into position in or across the pylorus.
  • Energy or a stimulus is then preferably applied to the pylorus to render it incompetent.
  • Energy may be in the form of, e.g., heat, electrical, chemical, RF, etc., or a combination.
  • Examples of chemical energy stimulus may comprise alcohol and sotrodecol.
  • the stimulus may be in the form of, e.g., dilatation, cutting, ablation, viral, etc., or a combination.
  • An example of a viral or chemical stimulus may be, e.g., a poison such as the botulinum toxin type A virus (Botox).
  • Botox An example of a method of use for Botox is described in U.S. Pat. No. 5,437,291 to Pasricha et al., which is incorporated herein by reference in its entirety.
  • An incompetent pylorus may allow stomach contents to drain directly into the proximal duodenum with minimal resistance.
  • some of the mentioned pyloroplasty treatments may be selected or designed to last only for a specific time period, e.g., a week or several months, etc.
  • the effects of simple dilatation or the injection of Botox may be designed to render the pylorus incompetent for only a few months, which may be a desirable time period for the patient to obtain the desired results of the procedure.
  • FIG. 30 shows an isometric view of one variation of a dilatation device in balloon device 510 which may have angioplasty balloon 512 located near or at the distal end of catheter 514 .
  • Angioplasty balloon 512 may be used alone to simply dilate the pylorus.
  • exterior balloon surface 516 may have at least one and preferably several stimulating members 518 disposed about surface 516 .
  • Stimulating members 518 are shown in the figure as cutting blades or wires, but alternatively, they may include electrodes, cryogenic dispensing probes or members, chemical dispensing probes, etc.
  • balloon 512 may alternatively be a dilation wire basket similarly disposed with stimulating members 518 .
  • FIG. 31 shows an isometric view of another variation in probe device 520 .
  • Device 520 may have catheter or delivery member 524 with, e.g., probes 526 , which may extend from distal end 522 . Although three probes 526 are shown in the figure, at least one and up to several probes of varying thickness and lengths may be used.
  • Probes 526 may be retractable so that during delivery through, e.g., the esophagus or stomach, probes 526 may be withdrawn within distal end 522 and then extended when treating the pylorus.
  • Probes 526 may be electrically connected to a voltage or power source located outside the patient's body to deliver electrical, RF, or heat energy to the pylorus.
  • probes 526 may be used to inject chemicals, e.g., alcohol, sotrodecol, or other ablative chemicals, or biological stimuli, e.g., Botox virus or some other incapacitating virus, into the pylorus.
  • chemicals e.g., alcohol, sotrodecol, or other ablative chemicals
  • biological stimuli e.g., Botox virus or some other incapacitating virus.
  • Such stimulants may be carried within distal end 522 , delivery catheter 524 , or they may also be delivered from the proximal end of catheter 524 and injected through to probes 526 .
  • FIGS. 32A and 32B Other variations which may be used for the pyloroplasty procedure are shown in FIGS. 32A and 32B.
  • FIG. 32A shows sphincterotome arm 530 having a distal end 532 . Arm 530 may be bent as shown to allow cutting member 534 to be drawn between distal end 532 and a location proximal of distal end 532 along arm 530 .
  • FIG. 32B shows delivery member 536 may have an arcuate support member 538 to support cutting member 540 .
  • FIGS. 32A and 32B shows sphincterotome arm 530 having a distal end 532 . Arm 530 may be bent as shown to allow cutting member 534 to be drawn between distal end 532 and a location proximal of distal end 532 along arm 530 .
  • delivery member 536 may have an arcuate support member 538 to support cutting member 540 .
  • 32A and 32B may be delivered via a catheter or endoscope trans-esophageally and through the stomach to the pylorus where either cutting member 534 , 540 may be used to cut or saw into the tissue in or around the pylorus to render it incompetent.
  • cutting member 534 , 540 may be used to cut or saw into the tissue in or around the pylorus to render it incompetent.
  • FIGS. 32A and 32B may be manufactured by Medi-Globe Corporation, located in Tempe, Ariz.
  • FIG. 33 shows stomach 550 with a distal portion of the wall of the lesser curvature removed for clarity.
  • Device 520 may be delivered through esophagus 552 to a location proximal of pylorus 558 , e.g., first position 554 . If probes 526 were retracted during delivery, they may then be extended, as shown. Distal end 522 of device 520 may be advanced to, e.g., second position 556 , such that probes 526 may pierce pylorus 558 to deliver the stimulus.
  • FIG. 34A shows an isometric view of another variation with combination device 560 .
  • Device 560 may have housing 562 on the distal end of delivery catheter or endoscope 564 .
  • Housing 562 defines notch 566 which may be oriented perpendicularly relative to the longitudinal axis defined by endoscope 564 .
  • Notch 566 preferably has a geometry large enough to accommodate part of pylorus 558 and housing 562 may be tapered at its distal end to allow for easy insertion into the pylorus 558 during the procedure.
  • Within notch 566 may be cutting blade 568 and on either side of blade 568 may be fasteners 570 , e.g., individual anchors, staples, etc.
  • housing 562 and endoscope 564 delivered through esophagus 552 The wall of stomach 550 is partially cut away for clarity.
  • Housing 562 may be inserted into pylorus 558 , then notch 566 is preferably aligned such that part of the pyloral sphincter lies within notch 566 .
  • the pyloral tissue may also be drawn into notch 566 via a vacuum or grasping member. Once the pyloral tissue is within notch 566 , cutting blade 568 may be actuated to traverse notch 566 and sever part of the tissue of pylorus 558 .
  • Fasteners 570 may then be deployed on either side of incision 572 to affix the incised tissue.
  • the number of incisions 572 may vary depending upon the desired degree of pyloric disablement.
  • an inflatable balloon may be attached on the back of notch 566 and inflated to push housing 562 into apposition with pylorus 558 and cause invagination of the tissue into notch 566 .
  • an additional anastomosis gastric bypass procedure may also be performed to further enhance treatment.
  • the anastomosis procedure may be performed preferably prior to, in conjunction with, or following the gastric reduction and pyloroplasty (if performed at all) procedures.
  • the anastomosis procedure as described herein may be omitted.
  • the procedure generally involves endoscopically or laparoscopically creating a side-to-side anastomosis preferably from within the stomach and bowel and within the digestive tract. This procedure may be similar to the Roux-en-Y gastric bypass (RYGB) procedure but with minimal trauma. This procedure may also effectively bypass food from the stomach, past a proximal portion of the bowel, and preferably directly into a lower portion of the bowel. This bypassed portion may be considered a malabsorption zone.
  • RYGB Roux-en-Y gastric bypass
  • FIG. 35 A representative and normal gastrointestinal system of a person is shown in FIG. 35 for comparison.
  • Stomach 580 is shown with pyloric sphincter 582 near gallbladder 584 and attached to the proximal section of duodenum 586 .
  • the distal section of duodenum 586 is attached to the proximal section of jejunum 588 , the distal section of which is further attached to the proximal section of ileum 590 .
  • Ileum 590 is then attached to ascending colon 592 , which continues through to the transverse colon (which has been removed for clarity), and then to descending colon 594 and finally to rectum 596 .
  • FIG. 36 A gastro-intestinal system which may be modified by a preferable anastomosis procedure is shown in FIG. 36 .
  • Stomach 600 is shown in this variation as having been modified by creating modified pouch 602 , which may be created by any of the methods and tools as described above.
  • Esophagus 603 is preferably connected to a proximal end of pouch 602 .
  • the distal end of pouch 602 may be connected directly to pylorus 604 or alternatively, may be a blind-ended pouch and pylorus 604 is connected to the proximal end of duodenum 606 .
  • a first anastomosis 608 may be created preferably between modified pouch 602 and a section of digestive tract either from the distal duodenum 606 or proximal jejunum 610 .
  • First anastomosis 608 may be located in a range from about 20 to 50 cm from pylorus 604 .
  • a second anastomosis 614 may be created preferably between a section of duodenum 606 and a section of ileum 612 .
  • the second anastomosis 614 may be located in a range from about 15 to 55 cm from pylorus 604 or about 150 to 200 cm down along the length of the small intestines from pylorus 604 .
  • This procedure may allow for drainage of secretions created by stomach 600 to pass through pylorus 604 and secretions of bile and chyme from the pancreas and gallbladder 618 to pass through biliary duct 620 partly through duodenum 606 and then through second anastomosis 614 and directly into distal ileum 616 and out of the body.
  • the bypassed stomach 600 , pylorus 604 , and proximal duodenum 606 may act as a malabsorption zone because sugars and fats which might normally be mostly absorbed in this zone may now be directly passed into the distal duodenum 606 or proximal jejunum 610 .
  • both first and second anastomoses 608 , 614 may be created first.
  • Duodenum 606 may then be closed off between the two anastomoses 608 , 614 .
  • pylorus 604 may be closed off or left open, depending upon the desired result and which of procedures and tools are implemented.
  • modified pouch 602 may be created after the anastomoses procedures.
  • modified pouch 602 may be created prior to the anastomoses procedures, again depending upon the desired result and which of procedures and tools are implemented. If modified pouch 602 were created first, then the anastomoses procedure may be reversed to essentially end with the same result.
  • FIG. 37 shows an isometric view of an assembly which may be utilized to achieve part of the procedure.
  • Deployment device 630 may have anastomosis assembly 632 preferably connected by steerable length 634 to manipulation handle 636 .
  • Assembly 632 may be steerable during insertion, preferably trans-esophageally and through the stomach, by steering grip 638 which may be located on manipulation handle 636 . Control by a physician or surgeon of manipulation handle 636 may be facilitated by handle 640 .
  • Anastomosis assembly 632 may have stapler housing 644 configured to fit intimately with distal element 646 preferably by a magnetic force, the use of which is described below.
  • Distal element 646 is preferably tapered or rounded on one side and may have a coring anvil 648 on its opposing side.
  • Coring anvil 648 may be tapered or rounded and may fit intimately into coring mate 650 which is preferably located near or at the center of stapler housing 644 .
  • Stapler housing 644 may also house several staples loaded within staple slots 652 , which may be disposed circumferentially around coring mate 650 and may be actuated from the proximal end of length 634 by staple trigger 642 .
  • FIG. 38 shows a cross sectioned view of anastomosis assembly 632 mated with distal element 646 at first anastomosis 608 between modified pouch 602 and jejunum 610 .
  • distal element 646 may first be placed within the appropriate section of jejunum 610 . This may be done by orally passing distal element 646 through the esophagus, stomach, and then through the duodenum.
  • Distal element 646 is preferably magnetized, either by manufacturing distal element 646 from natural ferrous materials or artificially magnetizing it. Because of the magnetization, distal element 646 may be urged through the body and into place within the duodenum by, e.g., magnetic wands or magnetic pickups, which may be manipulated from outside the patient's body.
  • stapler housing 644 which may be attached to steerable length 634 , may be introduced trans-esophageally into the stomach 602 and placed into position along stomach wall 660 at the desired site of first anastomosis 608 .
  • both stapler housing 644 and distal element 646 may then be coupled together preferably by the magnetic force and attraction between the two.
  • the two may be brought into alignment either by alignment grooves (not shown) or by the mating of coring anvil 648 into coring mate 650 .
  • part of stomach wall 660 and intestinal wall 662 are preferably held or maintained between stapler housing 644 and distal element 646 .
  • fasteners may optionally be deployed from stapler housing 644 through staple slots 652 and preferably through both stomach wall 660 and intestinal wall 662 into distal element 646 .
  • FIG. 38 shows staples 667 deployed as fasteners, but they may comprise any type of mechanical fasteners as described above, as well as, e.g., grommet-type swages, snap lock fits, staples, screws, clips, and friction-fittings.
  • the device may be left in apposition to maintain the position of stomach wall 660 and intestinal wall 662 for about one week. This may result in pressure necrosis of the tissue between stapler housing 644 and distal element 646 preferably causing the serosal layers of the gut to fuse, at which point the assembly may drop out and be passed, preferably leaving first anastomosis 608 behind.
  • a coring device 664 which may be slidingly contained within stapler housing 644 , may first be advanced through the center of stapler housing 644 and both stomach wall 660 and intestinal wall 662 to create first anastomosis 608 . The remaining assembly may then be left to cause the pressure necrosis and fusing of tissue, as described.
  • stapler housing 644 and distal element 646 may be used as a mechanism for a conventional end-to-end anastomosis (EEA) stapler.
  • EAA end-to-end anastomosis
  • a rod may be advanced through the center of the assembly to preferably lock distal element 646 to intestinal wall 662 .
  • the rod may be drawn back, preferably pulling a distal stapler segment into stapler housing 644 . This action may cause staples to fire and a circumferential blade to cut out the center of the staple ring, thereby creating an anastomosis.
  • FIG. 39 shows a portion of duodenum 606 juxtaposed to a portion of ileum 612 and distal ileum 616 with part of the intestinal walls removed for clarity.
  • proximal element 670 may be used and is preferably a magnetized mating element for distal element 646 .
  • Distal element 646 may first be urged to the desired location preferably in ileum 612 by, e.g., magnetic wands or magnetic pickups, which may be manipulated from outside the patient's body, in the same manner as above.
  • proximal element 670 may also be delivered or urged to the desired location in the same manner. Once both elements 646 , 670 are in position, they are preferably mated together by a magnetic force. The mating may optionally be enhanced by fasteners, e.g., staples 667 , to hold both elements 646 , 670 in position.
  • the intestinal wall inbetween may be cored, as described above, but it may also be simply left to undergo pressure necrosis between elements 646 , 670 eventually causing the serosal layers of the gut to fuse, at which point elements 646 , 670 may drop out and be passed, preferably leaving second anastomosis 614 behind.

Abstract

Various obesity treatment tools and methods are described herein, as well as treatments for other gastric-related diseases, e.g., GERD. Treatment includes reducing the size of the stomach pouch to limit the caloric intake as well as to provide an earlier feeling of satiety. This may be done by creating a smaller gastric pouch within the stomach directly from the interior of the stomach itself. The smaller pouches may be made through the use of individual anchoring devices, rotating probes, or volume reduction devices. A pyloroplasty procedure may also be performed to render the pyloric sphincter incompetent. A gastric bypass procedure may additionally be performed using atraumatic magnetic anastomoses devices so that sugars and fats are passed directly to the bowel while bypassing the stomach. Many of these procedures may be done in a variety of combinations. Treatment may create enforced behavioral modifications by discouraging the ingestion of high-caloric foods.

Description

TECHNICAL FIELD OF THE INVENTION
The present invention relates generally to tools and methods for the treatment of obesity. More particularly, the present invention relates to tools and methods for performing less traumatic gastroplasty procedures.
BACKGROUND OF THE INVENTION
Obesity is considered a major health problem with annual associated costs reaching $100 billion in the U.S. alone. Morbid obesity is a condition of obesity with the presence of a secondary debilitating progressive disease and is generally associated with a body mass index (BMI)≧40 kg/m2. While the basic mechanism of obesity is simply an imbalance between caloric intake and burn rate, the underlying factors are varied and complex and conservative attempts at sustained weight loss with this population are almost always unsuccessful. Often, there are genetic and other biological influences that may override environmental causes. Consequently, obesity is a disease that eludes a simple treatment, with a recurrence rate above 90% for those who attempt to lose weight. Moreover, long-term results using conservative treatments for morbid obesity are generally unsuccessful and are typically associated with further loss of self-esteem with the regaining of weight. Hypertension, cardiovascular disease, diabetes, along with a host of other comorbidities all make morbid obesity second only to smoking as a preventable cause of death.
Surgical procedures for obesity date back to 1889 (Billroth) with the earliest peer reviewed procedure being the jejuno-ileal bypass in 1954 (Kreman). A successful procedure is commonly defined as one that results in at least 50% excess weight loss at 2 years. Today, the most commonly done operation is the Roux-en-Y gastric bypass (RYGB), with around 35,000 performed annually in the U.S. Other forms of bariatric surgery include Fobi pouch, bilio-pancreatic diversion, and gastroplasty or “stomach stapling”. The single existing procedure that involves an implanted device is the Lap-Band, which is a laparoscopically installed inflatable cuff that is placed around the top of the stomach just below the lower esophageal sphincter (LES). This device affects satiety only (no reduced caloric absorption). Because there is more to obesity than simple overeating, it is unlikely that Lap-Band by itself will ever be as effective as a surgery that includes other physiologic feedback mechanisms.
The RYGB procedure is a procedure which has become very common in bariatric surgery. This procedure facilitates the movement of the jejunum to a high position by using a retrocolic Roux-en-Y loop. The procedure is generally performed through a 6-8 inch incision extending from the end of the breastbone to just above the navel. The stomach is completely divided into 2 unequal portions (a smaller upper and a larger lower gastric pouch) using an automatic stapling device with the raw surface reinforced with additional sutures. The upper pouch typically measures less than about 1 ounce or 20 cc, while the lower larger pouch remains generally intact and continues to secrete stomach juices flowing through the intestinal tract.
A segment of the small intestine (just distal of the duodenum or proximal of the jejunum) is then brought from the lower abdomen and joined with the upper pouch to form an end-to-end anastomosis created through a half-inch opening, also called the stoma. This segment of the small intestine is called the “Roux loop” and carries food from the upper pouch to the remainder of the intestines, where the food is digested. The remaining lower pouch and the attached segment of duodenum are then reconnected to form another anastomotic connection to the Roux loop at a location approximately 50-150 cm (1.6-4.9 ft) from the stoma, typically using a stapling instrument. It is at this connection that the digestive juices from the bypassed stomach, pancreas, and liver enter the jejunum or ileum to aid in the digesting of food. Due to the small size of the upper pouch, patients are forced to eat at a slower rate and are satiated much more quickly, thereby reducing the caloric intake (typically between about 1000-1200 Calories).
Because the food enters the intestines directly, conditions known as the “dumping syndrome” are created when certain types of “junk foods” are consumed (usually sweets and other simple carbohydrates). This creates unpleasant feelings of nausea, diarrhea, nervousness, and sweating, which in turn discourages patients from developing unhealthy eating patterns. With the RYGB procedure, a loss of at least 50% of excess body weight (EBW) is maintained in approximately 60% of patients at 5 years with a reduced complication rate than other procedures.
In creating the anastomoses in the RYGB procedure, several methods have previously been developed to maintain channel integrity. However, the conventional RYGB procedure requires a great deal of operative time and because of the degree of invasiveness, post-operative recovery time can be quite lengthy and painful.
Aside from the RYGB procedure, another gastrointestinal disease which relates to the stomach is gastroesophageal reflux disease (GERD). The lower esophageal sphincter is located in a distal portion of the esophagus adjacent to the junction between the esophagus and the stomach. When food is digested, a properly functioning lower esophageal sphincter would allow food to pass from the esophagus to the stomach while preventing reverse flow. However, GERD is a disorder where the esophageal sphincter allows the stomach contents, which includes gastric acid and bile, to flow back into the distal portion of the esophagus. Some complications associated with GERD include heartburn, pulmonary disorders, chest pain, esophageal ulcers, esophagitis, Barrett's esophagus, and esophageal carcinoma.
Common treatments for GERD include the administration of prescription acid blockers. But these drugs afford only short term relief; additionally, these drugs can be expensive and may have long-term side effects. Surgical procedures have included a procedure called the Nissen fundoplication, where a portion of the gastric fundus is wrapped around the esophagus. The wrapped fundus applies pressure to the esophagus to limit the reverse flow of the stomach contents. Effectively elongating the esophagus by fundoplication or by extending it via a staple line may be done to treat GERD. Conventional fundoplication procedures may be effective at treating GERD, but they also have disadvantages. For instance, many of these procedures require large incisions to be made in a patient. Laparoscopic procedures typically require several smaller incisions formed in the abdominal wall for the insertion of instruments into the patient's body. However, such procedures can be expensive and they can increase the risks of post-operative hernias, accidental organ perforations, and other related drawbacks.
Examples related to the field of gastroplasty are described below.
U.S. Pat. No. 5,549,621 to Bessler et al., which is incorporated herein by reference in its entirety, pertains to an apparatus and method for performing vertical banded gastroplasty without the use of staples. The described device uses at least two clamping bars to create a tubular-shaped pouch. However, the device is deployed laparoscopically onto the external surface of the stomach.
U.S. Pat. No. 5,382,231 to Shlain, which is incorporated herein by reference in its entirety, describes a device for transesophageal stomach retraction by a device having vacuum ports utilized to draw the stomach over the device. However, this device is used for manipulating and retracting a patient's stomach from the inside during a variety of surgical procedures and is not a permanent procedure for creating an internal pouch within the stomach itself.
U.S. Pat. No. 5,345,949 to Shlain, which is incorporated herein by reference in its entirety, relates to laparoscopic methods and tools for inserting a banding device to bring the walls of the stomach adjacent to one another between the proximal pouch and the distal region of the stomach. But there is no procedure for the creation of an internal pouch internally created from the stomach.
Examples related to the field of GERD treatment are described below.
U.S. Pat. No. 6,159,146 to El Gazayerli, which is incorporated herein by reference in its entirety, relates to a device which is inserted transesophageally and engages the inside anterior wall of the fundus and secures it to the side of the esophagus.
U.S. Pat. No. 6,113,609 to Adams, which is incorporated herein by reference in its entirety, pertains to a system which includes placement of a distal anchor through a hole formed in the wall of the esophagus and through a hole formed in the gastric wall, which are then fastened together.
U.S. Pat. No. 5,571,116 to Bolanos et al., which is incorporated herein by reference in its entirety, pertains to an invagination device which approximates the lower esophagus and the fundus of the stomach.
However, all of these examples are limited to treatments for GERD which involves the attachment of the fundus, or upper portion of the stomach, to the esophagus.
SUMMARY OF THE INVENTION
Various tools and methods of treatment for obesity are described herein which are less traumatic and less invasive than procedures currently available. A variety of methods for the treatment of obesity, as well as other gastric-related diseases, e.g., gastroesophageal reflux disease (GERD), are disclosed. One method involves reducing the size of the stomach pouch to limit the caloric intake as well as to provide an earlier feeling of satiety. This may be done by creating a smaller gastric pouch within the stomach. This procedure optionally may be enhanced by performing a pyloroplasty prior to and/or in conjunction with the pouch size reduction, i.e., rendering the pyloric sphincter incompetent. This increases the rate of stomach emptying, allowing sugars and fats to pass directly into the bowel, thereby inducing dumping. Moreover, the food in the stomach may be made to also bypass a proximal portion of the bowel, i.e., a portion of the duodenum and jejunum, by creating a gastric anastomosis thereby creating a malabsorption of sugars and fats which are mostly absorbed in the bypassed portion of the duodenum and jejunum. Sugars and fats entering the bowel directly from the stomach rather than passing through the pylorus and proximal duodenum and jejunum may cause “dumping” syndrome and diarrhea. This in turn may create enforced behavioral modifications, thereby discouraging the patient from eating these types of high-caloric foods.
In forming a modified pouch, a marking device, such as a bougie, may be used at the beginning of the procedure, to create a dye marker “road map” on the interior surface of the stomach from the pylorus to the esophagus. This may enable visualization by, e.g., an endoscope, to give the physician a clear reference point for staple or fixation element placement. A distal balloon, which is preferably attached to an inflation tip at a distal end, may be inserted into the pylorus to stabilize the bougie during the procedure and may be inflated from the proximal end of the tubing by the physician.
In reducing the stomach size, one variation involves grasping the interior walls of the stomach, preferably via an endoscope advanced trans-esophageally, and placing one to several individual fixation elements on opposing interior walls and then bringing those fixation elements together. The stomach pouch may be modified and/or created by a variety of other device variations utilizing other methods, e.g., stapling opposing sides of a stomach together to form two separate lumens from within the interior surface of the stomach. An endoscopic stapling device may be used to accomplish such a task. Such an endoscopic stapler preferably brings two regions of tissue into apposition and may then apply a fastening element, e.g., staples, clips, tags, screws, etc., into the two regions of tissue to affix them together.
In addition to endoscopically applied stapling and clip devices, rotating and rotatable probes may also be used to form a modified smaller lumen within a main lumen. Such probes generally may be inserted into a stomach endoscopically and may engage a portion of the interior lining of the stomach and may then be rotated to roll the engaged portion of the stomach wall around the probe itself to bring the wall in apposition with another portion of the stomach wall. Such rotating probes may be used to create a blind-ended pouch of stomach within the main stomach lumen, or as with the other devices, may be used to create a smaller pouch exiting into the pylorus. Once the roll of stomach wall is brought into apposition, a row or a plurality of fasteners, e.g., staples, blind staples, clips, tags, adhesives, screws, etc., may be used to maintain the stomach. Moreover, other variations may include gastric volume reduction devices as part of the present invention. Such volume reduction devices generally may be inserted into a stomach trans-esophageally through the use of, e.g., an endoscope. The reduction device may be used to draw or engage a portion of the interior lining of the stomach; the drawn or engaged portion may then be eventually removed, either actively or through natural processes, e.g., pressure necrosis.
To aid in the overall effect, a pyloroplasty procedure may also be performed to enhance treatment. The pyloroplasty may be performed prior to (preferable), in conjunction with, or following the gastric reduction procedure. A pyloroplasty procedure typically results in the pyloric sphincter being rendered incompetent. Generally, a pyloroplasty device may be passed endoscopically through the esophagus, into the stomach, and preferably into position in or across the pylorus. Energy or a stimulus is then preferably applied to the pylorus to render it incompetent.
Moreover, an additional anastomosis gastric bypass procedure may also be performed to further enhance treatment. The anastomosis procedure may be performed preferably prior to, in conjunction with, or following the gastric reduction and pyloroplasty procedures (if performed at all). The procedure generally involves endoscopically or laparoscopically creating a side-to-side anastomosis preferably from within the stomach and bowel and within the digestive tract. This procedure may be similar to the Roux-en-Y gastric bypass procedure but with minimal trauma.
BRIEF DESCRIPTION OF THE DRAWINGS
FIG. 1A shows an example of a modified stomach having a smaller pouch created from the interior surface lining.
FIG. 1B shows a partial superior view of the cross section from FIG. 1A.
FIG. 2 shows a variation on a marking device or bougie for marking the interior surface of a stomach.
FIG. 3A shows a variation on positioning a marking device inserted into a stomach.
FIG. 3B shows a cross section view from FIG. 3A of a deflated stomach around the marking device.
FIG. 3C shows the cross section view from FIG. 3B of an insufflated stomach with the resulting marks.
FIG. 4A shows a view of the interior of the lesser curvature of a stomach with anchors attached.
FIG. 4B shows a cross section view from FIG. 4A with the anchors attached.
FIG. 5A shows a side view of a crimping variation on a fastening device.
FIGS. 5B and 5C show a superior and side view, respectively, of several interlocked crimping devices from FIG. 5A.
FIG. 6A shows an isometric view of a zip-tie or ratcheted variation on a fastening device.
FIG. 6B shows a superior view of the device of FIG. 6A attached to the stomach wall.
FIG. 6C shows a superior view of another double zip-tie variation on a fastening device.
FIG. 6D shows the stomach of FIG. 6B with the fasteners cinched.
FIG. 6E shows a superior view of another perpendicular zip-tie variation on a fastening device.
FIGS. 7A and 7B show a superior view of an extendable double hook device attaching to a stomach wall.
FIG. 7C shows the device of FIG. 7A locked by a crimping variation.
FIGS. 8A and 8B show a superior view of a modified stomach maintained by a fastening staple.
FIGS. 9A and 9B show isometric views of a variation on an endoscopic stapling device.
FIG. 10 shows an isometric view of a variation on a box stapling device.
FIG. 11A shows an assembly view of another stapling device variation.
FIG. 11B shows a side view of the device of FIG. 11A.
FIG. 12A shows an isometric view of a crescent shaped variation of a stapling device.
FIG. 12B shows an end view of the device of FIG. 12A showing a staple deploying.
FIG. 12C shows an interior side view of the device of FIG. 12A with a translating wedge sequentially deploying staples.
FIG. 13 shows an interior view of a stomach with an example of stapling device placement.
FIG. 14 shows an interior view of a stomach with an example of a modified stapling device which may be used for the treatment of GERD.
FIG. 15A shows an assembly view of a variation on an approximating device.
FIGS. 15B to 15D show the process of invaginating stomach interior lining and fastening using the device of FIG. 15A.
FIGS. 15E shows the assembly view of another variation of the device of FIG. 15A wherein the clip may be replaced by a screw.
FIGS. 15F to 15H show the process of invaginating stomach interior lining and fastening using the device of FIG. 15E.
FIG. 16A shows an example of a modified stomach created by a rotating device variation.
FIG. 16B shows a superior cross section view of the stomach of FIG. 16A where the modified lumen may be created by rotating the interior stomach lining upon itself.
FIG. 16C shows an alternate superior cross section view of the stomach of FIG. 16A where the modified lumen may be created by rotating apposed portions of the interior stomach lining upon itself.
FIGS. 17A and 17B show an isometric and cross section view, respectively, of a vacuum tube variation.
FIGS. 18A and 18B show an isometric and cross section view, respectively, of a counter-rotating vacuum tube variation.
FIGS. 19A and 19B show an isometric and cross section view, respectively, of a vacuum tube variation with attachment points.
FIGS. 20A and 20B show an isometric and cross section view, respectively, of a split tube variation.
FIG. 21 shows an example of placement within a stomach of a rotatable device variation.
FIGS. 22A and 22B show the possible creation of a rotated lumen using the device of FIGS. 19A and 19B.
FIGS. 23A to 23D show the possible creation of a rotated lumen using the device of FIGS. 20A and 20B.
FIG. 24A shows an isometric view of a variation on a dual rotatable tube device.
FIGS. 24B and 24C show an end view and cross section view, respectively, of the device of FIG. 24A.
FIG. 25A shows a variation on an endoscopic vacuum device in a stomach.
FIGS. 25B and 25C show an end view of a variation on lumen creation from the interior surface of the stomach using the device of FIG. 25A.
FIG. 26 shows an isometric view of a variation on a gastric volume reduction device.
FIGS. 27A to 27D show the device of FIG. 26 inserted into a stomach to draw or cinch up lining tissue to reduce a volume of the stomach.
FIG. 28 shows another variation on a gastric volume reduction device utilizing a grasping device and a ligating device.
FIGS. 29A and 29B show an isometric view on a variation of a gastric volume reduction device utilizing tractive rollers to draw tissue up between them.
FIG. 29C shows another variation of the device of FIGS. 29A and 29B with ratcheted rollers.
FIG. 30 shows an isometric view of a variation on a pyloroplasty device with an angioplasty balloon.
FIG. 31 shows an isometric view of another variation on a pyloroplasty device with extendable probes.
FIGS. 32A and 32B show variations on sphincterotome arms for use in a pyloroplasty procedure.
FIG. 33 shows a stomach with a distal portion of the wall of the lesser curvature removed to show a possible use for the device of FIG. 31.
FIG. 34A shows an isometric view of another variation on a pyloroplasty device with a combination cutting and stapling notch.
FIG. 34B shows the device of FIG. 34A in a possible use in a stomach.
FIG. 35 shows a representative and normal gastro-intestinal system of a person.
FIG. 36 shows an example of a gastro-intestinal system modified by a preferable anastomosis procedure.
FIG. 37 shows an isometric view of a variation on an anastomosis deployment device.
FIG. 38 shows a cross section view of an anastomosis assembly mating a portion of the stomach with a portion of the intestinal tract.
FIG. 39 shows a cross section view of another anastomosis assembly mating two different portions of the intestinal tract.
DETAILED DESCRIPTION OF THE INVENTION
With obesity becoming an increasing problem, various tools and methods of treatment are described herein which are less traumatic and less invasive than procedures currently available. As described in further detail below, a variety of methods for the treatment of obesity, as well as other gastric-related diseases, are disclosed. Generally, the size of the stomach pouch may be reduced to limit the caloric intake as well as to provide an earlier feeling of satiety. This may be accomplished by creating a smaller gastric pouch within the stomach by a variety of methods. This procedure optionally may be enhanced by performing a pyloroplasty prior to and/or in conjunction with the pouch size reduction, i.e., rendering the pyloric sphincter incompetent. Additionally, the food in the stomach may be made to also bypass a proximal portion of the bowel, i.e., a portion of the duodenum and jejunum, by creating a gastric anastomosis thereby creating a malabsorption of sugars and fats which are mostly absorbed in the bypassed portion of the duodenum and jejunum. Sugars and fats entering the bowel directly from the stomach rather than passing through the pylorus and proximal duodenum and jejunum may cause “dumping” syndrome and diarrhea. Moreover, rendering the pylorus incompetent may also lead to dumping syndrome partly because of the rapid gastric emptying which may occur. This in turn may create enforced behavioral modifications, thereby discouraging the patient from eating these types of high-caloric foods.
FIG. 1A shows an example of a modified stomach 10 which may be created, by any one of the methods described below, as part of the present invention. Greater curvature 12 and lesser curvature 14 is seen in modified stomach 10, as well as the distal end of esophagus 16 and pylorus 18. As part of the present invention, stomach 10 may be divided along junction 24 into modified pouch 22, which is preferably less than about 1 ounce in volume, and main pouch 20. FIG. 1B shows a partial superior view of the cross section of main pouch 20 and modified pouch 22 as viewed from cutting plane P from FIG. 1A. As seen, modified lumen 26 is preferably formed by junction 24 from main lumen 28 by joining a portion of stomach wall 30. During ingestion of food, modified pouch 22 accepts food from esophagus 16 and preferably passes it directly through modified lumen 26 into pylorus 18. Main pouch 20 may remain intact and function normally, but preferably sees little or no food. Acids and other fluids that may be generated in main lumen 28 may drain through the reduced outlet near pylorus 18 and may pass through the digestive system normally.
Marking Tools and Methods
As part of forming a modified pouch, a marking device may be used, preferably at the beginning of the procedure, to create a dye marker “road map” on the interior surface of the stomach from the pylorus to the esophagus. Once such dye marks are placed, they may be visualized, e.g., endoscopically, thereby giving the physician a clear reference point for staple or fixation element placement. An example of such a marking device is shown in FIG. 2 as marking device or bougie 40. Bougie 40 is preferably an elongated device made from tubing member 44 which may have several channels defined within. Tubing 44 may be made from any variety of biocompatible materials, e.g., stainless steel, plastics, etc., and preferably has a diameter and cross section which is similar to that of the finished modified lesser pouch. Along the length may be defined a series of dye ports 46 through which the marking dye may be channeled through from the proximal end of bougie 40. Any variety of biocompatible dyes which preferably enhance visualization may be used, e.g., methylene blue, thionine, acridine orange, acridine yellow, acriflavine, quinacrine and its derivatives, brilliant green, gentian violet, crystal violet, triphenyl methane, bis naphthalene, trypan blue, and trypan red. Also along the length and on either side of dye ports 46 may be a series of vacuum ports 48, which are optional. A distal balloon 52, which may be inserted into the pylorus to stabilize bougie 40 during the procedure, is preferably attached to inflation tip 50 at distal end 42 and may be inflated from the proximal end of tubing 44 by the physician.
FIGS. 3A to 3 C show bougie 40 during one method of use. FIG. 3A shows stomach 60 as bougie 40 is inserted down through esophagus 62. As bougie 40 is advanced down to pylorus 76, distal balloon 52 may be inflated through inflation tip 50, thus securing the device. Bougie 40 preferably follows lesser curvature 64 and may alternatively be shaped to approximate lesser curvature 64. Bougie 40 is also preferably rotated such that dye ports 46 face away from lesser curvature 64 and face towards greater curvature 66. Then the air and fluids contained within stomach 60 are preferably removed, either through vacuum ports 48, if they are included in bougie 40, or through another vacuum port which may be introduced endoscopically through esophagus 62. FIG. 3B shows cross section 3B—3B from FIG. 3A as deflated stomach 60. Once deflated, modified lumen 70 may take shape around bougie 40, separate from deflated main lumen 68. In this deflated state, the dye may be channeled through dye ports 46, thereby leaving dye marks 72 on interior lining 74. Once the staining has been performed, lumen 68 may be insufflated, as shown in FIG. 3C, and bougie 40 may then be removed. As seen in FIG. 3C, dye marks 72 mark or delineate the junction region where anchors or fasteners may be placed to draw interior lining 74 together to form the modified lumen.
Gastric Reduction Tools and Methods Using Fasteners
One variation of reducing the stomach size involves grasping the interior walls of the stomach, preferably via an endoscope advanced trans-esophageally, and placing one to several fixation elements on opposing interior walls and then bringing those fixation elements together.
Several examples of different possible variations on fasteners are shown and described below. These variations are not intended to be limiting but are merely given as illustrative examples.
FIG. 4A shows a view of the interior of the lesser curvature of stomach 60 with part of the greater curvature wall removed. As seen, individual anchors 80 may be secured to the interior surface along the junction 24 where modified pouch 22 from FIG. 1A would form. Anchors 80 may be of any biocompatible material, e.g., stainless steel, polymers, etc., which may be formed into a variety of fasteners, e.g., staples, ratcheted wires, zip ties, clips, tags, eyelets, crimps, and screws. Anchors 80 may be placed by estimating the junction boundary, but they are preferably located along dye mark 72, which may be formed by methods and tools described above, prior to anchor 80 placement, as shown in FIG. 4B, which is cross section 4B—4B from FIG. 4A. After anchors 80 have been fastened, suture 82 may be drawn through each of the anchors 80, preferably in a zig-zag manner, and then suture 82 may be drawn tight to bring the opposing surfaces of interior lining 74 together in apposition along dye marks 72 to form the modified lumen. Alternatively, individual anchors 80 may be preloaded or prefastened by suture 82, and anchors 80 may be fastened to interior lining 74 in this manner.
FIG. 5A shows a side view of a variation on a fastening device in crimping member 90. Crimping member 90 is preferably made from a biocompatible material, e.g., stainless steel, nitinol, etc., and may be formed to have elbow 92 extend into two opposing anchoring ends 94. FIG. 5B shows a superior view of a created modified lumen 100 formed from main lumen 98 by any of the methods described herein. In this variation, several crimping members 90 may be attached or fastened to interior lining 96 by anchoring ends 94. As they become attached, each of the members 90 are preferably configured to interlock with an adjacent crimping member 90, much like a zipper. FIG. 5B shows the interlocked members 90 from the top to form lumen 100 and FIG. 5C shows the view from 5C—5C from FIG. 5B where each of the crimping members 90 are shown interlocking at their elbows 92 like a zipper.
FIG. 6A shows an isometric view of another variation on a fastening device in ratcheted wire or zip tie 110. This particular variation shows a distal tip or male end 112 and a corresponding proximal end or female end 114, with ratcheted length 116 between those two ends. FIG. 6B shows a superior view of stomach wall 120 just prior to the formation of modified lumen 124 from main lumen 122. As seen, male end 112 of first zip tie 110′ may be pierced through one side of interior lining 118 and second zip tie 110″ may be pierced through the opposing side of interior lining 118 such that the male ends 112 of each zip tie preferably correspond to the female ends 114 of the other zip tie. To then form the lumen 124, each zip tie 110′, 110″ may be drawn together and tightened accordingly, as shown in FIG. 6D. A plurality of zip ties 110 are preferably used to form modified lumen 124 by aligning them by any of the methods described above.
An alternative zip tie device which may be used is a perpendicular type version of zip tie 110. As shown in FIG. 6E, first perpendicular zip tie 134′ and second perpendicular zip tie 134″ may be used in place of zip tie 110 and lumen 124 may be formed in much the same manner as described above to result in the modified stomach as shown in FIG. 6E. A further alternative is shown in FIG. 6C where male zip tie 126 preferably has dual piercing male ends with catcher tubes 128. In this variation, a vacuum-type device, as described below in detail, or forceps may be used to draw portions of stomach wall 120 in apposition. As the apposed stomach walls 120 are positioned, needles 130, which are preferably passed through a double female zip tip 132, may be used to pierce through tissue 120 and lock into catcher tubes 128. Needles 130 may then be drawn back through tissue 120, while simultaneously pulling male ends/catcher tubes 128 back through tissue 120 and into the corresponding double female zip tie 132. The locked zip tie 126 may then be drawn tight against female zip tie 132, trimmed, and then released. This procedure may be repeated for any number of zip ties which may be used to draw the stomach lining together to form the smaller pouch and may also be used with the dye marking device 40 and procedure as described above.
A further variation on the individual anchoring fasteners is shown in FIG. 7A. This variation shows gasping device 140 with retaining tube 142 and extendable members 146 which may extend from distal opening 144. Extendable members 146 are preferably made from a biocompatible material, e.g., superelastic or shape memory alloy such as nitinol, which may be biased to urge away from a longitudinal axis defined by tube 142 once extended beyond distal opening 144. As members 146 extend, they may reach out to grasp apposed portions of interior lining 150 by hooks 148. As above, the locations where hooks 148 grasp may be defined by the marking device as described above and viewed by the physician through, e.g., an endoscope. Once hooks 148 have grasped the appropriate portion of lining 150, members 146 may then be drawn back through distal opening 144, as shown in FIG. 7B, and a retaining device, such as crimp 152, may be slid over a distal section of members 146, as shown in FIG. 7C, to maintain the position of hooks 148 and apposed lining 150 to create the desired lumen.
Gastric Reduction Tools and Methods Using Stapling Devices
Aside from individual anchoring and fastening devices, the stomach pouch may be modified and/or created by a variety of other device variations utilizing other methods. FIG. 8A shows the cross sectioned superior view of FIG. 1B with the addition of staple 160 maintaining junction 24. The figure shows an example of how, e.g., an endoscopically applied stapler, may be used to retain and hold junction 24 to form modified lumen 26. FIG. 8B shows a close-up view of the junction 24 and staple 160 which was applied from within lumen 26.
To staple opposing sides of a stomach together to form two separate lumens from within the interior surface of the stomach, an endoscopic stapling device may be used to accomplish such a task. Such an endoscopic stapler preferably brings two regions of tissue into apposition and may then apply a fastening element, e.g., staples, clips, tags, etc., into the two regions of tissue to affix them together. These stapling devices may optionally incorporate the use of the marking device or bougie 40, as described above, as a preliminary step as a guide to vacuum placement and/or stapling to form the desired modified lumen. The fastening elements, e.g., staples, are preferably made of a biocompatible material such as stainless steel, titanium, polymers, sutures, nitinol, or any other similar metals and alloys, etc. and may be in any conventional shape such as C-shaped and U-shaped staples or any of the other shapes as described herein. The two regions of tissue may be adhered to the stapling device by a variety of attachment methods, e.g., tines, barbs, hooks, vacuum, or any combinations thereof. In an adhering device utilizing a vacuum to hold the apposing regions of tissue together, such a device may be a tubular or wand-shaped member and preferably has at least two windows which may be spaced about the circumference of the tube or wand. These windows may be separated by an arc in a range of about 20° to 180° about the longitudinal axis defined by the length of the tube or wand, and are preferably separated by an arc in a range of about 90° to 180°.
Several examples of different possible variations on the stapling device are shown and described below. These variations are not intended to be limiting but are merely given as illustrative examples.
FIG. 9A shows a variation of an endoscopic stapling device in the isometric view of anvil stapling device 170. Stapling unit 172 is shown attached to the distal end of tube 174. Within stapling unit 172 is staple enclosure 176 where staples may be loaded and vacuum ports 178 which are seen in an alternating fashion with staple slots 180, through which the staples may be deployed. FIG. 9B shows a reverse isometric view of the device of FIG. 9A. As seen, stapling unit 172 may have septum 184 insertable into septum slot 186, which is preferably midway between the sides of staple enclosure 176 and which may separate the interior of staple enclosure 176 into two separate chambers. Septum 184 may serve several functions, one of which may be to allow selective activation of opposing sides of vacuum ports 178 of unit 172 as tissue is selectively adhered to the device. Other functions of septum 184 are discussed below.
In operation, stapling unit 172 may be inserted trans-esophageally into a stomach and a first portion of the interior lining may be adhered to a single side of staple enclosure 176 through a vacuum created within vacuum ports 178. The vacuum may be created in stapling unit 172 through tube 174 and activated from the proximal end of tube 174 from outside the patient's body. Once the first portion of the interior lining is adhered to one side of staple enclosure 176, the opposite set of vacuum ports 178 may be activated and unit 172 may be used to draw the first portion to an opposing second portion of the interior lining, which may then be adhered to the device such that the first portion and the second portion are preferably in apposition to each other. This action preferably forms the modified lumen 26 of FIGS. 8A and 8B. As the tissue is held to unit 172, septum 184 may be withdrawn from septum slot 186 by introduced forceps through, e.g., an endoscopic or through an integral actuator, to form a single chamber within staple enclosure 176. Removal of septum 184 may then bring the first and second portions of tissue into contact apposition. The side surfaces 188 of septum 184 may incorporate a cutting, abrading, scoring, heating, freezing, chemically damaging, or some other damaging surface to tissue. Such a surface 188 may damage the interior lining contacting each other upon removal of septum 184 as surface 188 slides past. This damage may encourage a more vigorous healing response and a more permanent fixation between the damaged tissue once stapled or affixed together.
After removal of septum 184, the staples loaded within staple enclosure 176 may be fired through staple slots 180 to affix the tissue. As the staples are fired, anvil 182 may be used as an anvil to secure the staples to the tissue, thereby resulting in the modified lumen 26 as shown in FIG. 8B. The length of stapling device 170 may be made according to the desired junction length and the size of the patient's stomach. This particular variation may be withdrawn from the area after the stapling procedure by first pushing the stapling device 170 past the resulting staple line.
FIG. 10 shows an isometric view of another variation in box stapling device 190. Stapling unit 192 is shown as being attached in fluid communication to vacuum tube 193. Stapling device 190 may be inserted and operated in the same manner as device 170 described above. Stapling unit 192 may have vacuum ports 194 activated selectively on either side of septum 196 as described above. The tips of staples 198 are shown partially deployed for illustration purposes, but are preferably not deployed until septum 196 is first retracted preferably in the direction as indicated. Septum 196 may also be configured to damage the contacting tissue upon septum 196 withdrawal in the same manner as described above. Stapling device 190 may be easily applied and removed after staples 198 have been deployed.
FIG. 11A shows an assembly isometric view of another variation in stapling device 200. This variation 200 shows curved tube 202 which may have lumen 204 house staples 206 as well as act as a combination vacuum and staple slot 216. Tube 202 may be shaped in a variety of ways but is shown here as a C-shaped or U-shaped tube with first channel 210′ and second channel 210″, for adhering the two apposed portions of tissue, preferably separated by removable septum 212. With this variation 200, tissue may be adhered within the channels 210′, 210″ through vacuum/staple slot 216 and once positioned, staples 206 may be deployed while septum 212 is removed simultaneously by the use of curved wedge 218. In operation, curved wedge 218 may be drawn within lumen 204 from the tube 202 distal end to the proximal end by, e.g., a pull-wire attached to wedge 218. As wedge 218 is advanced proximally, wedge 218 would preferably force pivot 208 of staple 206 against contact edge 214 of septum 212. As wedge 218 is advanced further proximally, urging end 220 may then urge the curved ends of staple 206 to rotate about pivot 208 and deploy through slot 216. While staple 206 is deploying, notch 222, preferably located at a distal end of wedge 218, may engage contact edge 214 and begin to slide septum 212 simultaneously towards the proximal end of tube 202. FIG. 11B shows a side view of stapling device 200 of FIG. 11A. As seen, curved wedge 218 preferably contacts septum 212 via notch 222 and pushes while simultaneously urging staple 206 to deploy. The figures show a single staple 206 for illustrative purposes only and any plurality of staples 206 may be used in practice depending upon the desired results.
FIG. 12A shows an isometric view of yet another variation in stapling device 230. This variation may omit a removable septum. Curved tube 232 is preferably curved in this variation in a crescent shape forming contact channel 234. Within contact channel 234, a number of vacuum ports 236 and staple slots 238 may be defined in an alternating pattern, as shown. A possible W-shaped staple 240 preferably having pivot 242 at the staple 240 midpoint is shown outside of tube 232 for illustrative purposes in a possible orientation for insertion within staple slots 238. FIG. 12B shows cross section 12B—12B from FIG. 12A. As seen, tube 232 defines lumen 244, which preferably runs the length of tube 232, and translating wedge 246 which is preferably slidingly disposed within lumen 244. As seen in FIGS. 12B and 12C, which is a side view of the interior of tube 232, wedge 246 may be translated by pull-wire 248. Pull-wire 248, which may be made of any high-strength material, e.g., stainless steel, nitinol, nylon, polymers, etc., may be manipulated by a physician from the proximal end of tube 232 from outside of the patient's body. Like the device 200 of FIGS. 11A and 11B, once vacuum ports 236 have acquired the interior tissue lining to be approximated, translating wedge 246 may be advanced proximally. Advancing wedge 246 may urge staples 240 to deploy through staple slots 238 sequentially as shown to hold the tissue and form the desired lumen.
An example of deployment for any of the stapling devices described above is shown in FIG. 13. As shown, stomach 250 with the wall partially cut out is seen with stapling device 252 inserted within. Stapling device 252 is shown merely as an example of insertion and could comprise any of the devices described herein. Device 252, which is preferably advanced trans-orally into stomach 250 and through esophagus 256, is preferably located at the distal end of delivery/vacuum tube 254. Once inserted, device 252 may be located by the assistance of the lesser curvature 258 of stomach 250. Also shown are vacuum/staple ports 260, which may be any of the configurations as described herein. In a preferable variation, stapling device 252 may be configured to produce a staple line or junction following the lesser curvature beginning from cardiac notch 264 down towards pylorus 262. Accordingly, device 252 may have the length and vacuum/staple ports 260 configured such that the distal end of device 252 points towards pylorus 262.
FIG. 14 shows stapling device 270 in a slightly different configuration for the treatment of other gastrointestinal diseases such as gastroesophageal reflux disease (GERD), as discussed above. The stomach 250 of FIG. 13 is shown, but for the treatment of GERD, stapling device 270 may be slightly modified such that the device 270 and vacuum/staple ports 272 may be straight or flared away from, rather than towards, lesser curvature 258 and pylorus 262 as described above. As such, vacuum/staple ports 272 would preferably produce a staple line or junction beginning from cardiac notch 264 and then flares away from lesser curvature 258 and pylorus 262. Device 270 may be any of the devices described and operated herein, but for the flared modification. Likewise, any of the devices described herein may be used for the treatment of GERD by simply angling the device to produce a flared staple line. Alternatively, a simple non-flared staple line may also suffice for treating GERD. The staple line may act as a Heimlich valve which preferably closes down in response to pressure exerted from the greater or main lumen. Moreover, the smaller volume of the modified lumen in-line with esophagus 256 may provide a smaller volume of acid available for esophageal reflux.
An isometric view of a single channel vacuum device variation is shown in FIG. 15A in approximating device 280. Tube 282 is preferably a tubular device which may be inserted into a stomach through the esophagus of a patient. A lumen 284 may run through tube 282 from a proximal end to the distal end of tube 282. At the distal end, two or more windows or slots 286 are preferably defined opposite of one another, as shown. The lengths and widths of slots 286 may vary and is preferably long enough to approximate the desired length of the boundary or junction line of the modified lumen; likewise, the width is preferably wide enough to accommodate at least two layers of the stomach interior lining. Approximating clip 288 is shown having at least two piercing ends 290 and may be loaded into tube lumen 284 from either the proximal end or distal end of tube 282 preferably prior to inserting the device 280 into the patient. Clip 288 is preferably made of a biocompatible material as described above. Biodegradable plug 292 may be placed into the distal end of tube 282 prior to insertion into the patient and is preferably made of a biocompatible biodegradable material, e.g., biodegradable polymers such as polylactide, polyglycolide, and their copolymers. Plug 292 may be alternatively made from a non-biodegradable material and may simply pass after the procedure. Plug 292 may aid in maintaining a vacuum seal through slots 286 during the approximation procedure, as described below.
FIG. 15B shows an end view from section 15B—15B from FIG. 15A of tube 282 in operation. As shown, opposing portions of stomach interior lining 294 may be drawn into lumen 284 through opposing slots 286 by creating a vacuum within lumen 284. Approximating clip 288 may be urged distally through tube 282 such that each of ends 290 may be drawn through a corresponding slot 286 over and/or pierced through lining 294 within lumen 284. As lining 294 is approximated within lumen 284, biodegradable plug 292 may become invaginated within lining 294. Accordingly, as clip 288 and ends 290 are positioned over lining 294, tube 282 may be withdrawn from the area while clip 288 preferably slides through the distal end of tube 282 leaving the approximated interior lining 294 held in position by ends 290, as seen in FIG. 15D. Removal of tube 282 may urge plug 292 to slide off the distal end of tube 282 and remain within the newly formed lumen to become degraded over time or to pass through the patient's system.
FIG. 15E shows the device of FIG. 15A, but in this variation, clip 288 may be replaced by screw 289, which is preferably in the shape of a helix or coil having a tapering width or diameter. The first few turns or coils of screw 289 may have the same or similar diameter than the remaining tapering coils; this may enable piercing end 291 to engage interior 294 and may also allow screw 289 to be advanced at the desired orientation through the tissue. Screw 289 preferably maintains a parallel orientation with tube 282 during delivery into the tissue, i.e., a longitudinal axis defined by screw 289 is preferably parallel, or close to parallel, with the longitudinal axis defined by tube 282. Moreover, the outer diameter of the first few turns or coils are preferably the same diameter, or slightly less than, the inner diameter of tube 282. This may further enable screw 289 to be advanced through lumen 284 at the proper orientation prior to engaging interior 294.
As described above for the device of FIGS. 15A to 15D, opposing portions of stomach interior lining 294 may be drawn into lumen 284 through opposing slots 286 by creating a vacuum within lumen 284, as shown in FIG. 15F. Screw 289 may then be urged through lumen 284 and rotated in the direction of the arrow shown until piercing end 291 engages the invaginated lining 294. Piercing end 291 preferably is sharp and needle-like to enable piercing through multiple layers of lining 294. As screw 289 is further rotated, it may be further advanced distally through the remaining portion of invaginated lining 294. The tapering diameter and decreasing width may also begin to further approximate the opposing edges of lining 294 towards one another, as shown in FIG. 15G. Finally, as seen in FIG. 15H, further advancement of screw 289 preferably draws the opposing surfaces into contact with one another. Tube 282 may then be removed, as described above. Although the fixation of one screw 289 is described, multiple screws 289 may be fastened one after another to form a continuous fixation line.
Screw 289 may be made of a bioabsorbable or biocompatible material, as described herein such as a polymer or superelastic alloy, and may be integrally formed with barbs or whisker-like filaments protruding along its length to help prevent screw 289 from backing out once it has been engaged within the lining 294. An example of a spiraling suturing needle or screw which may be used in this variation is shown and described in U.S. Pat. No. 5,330,503 to Yoon, which is incorporated herein by reference in its entirety. Another example of a helical fastener or screw and applicator which may be used in this or another variation is shown and described in U.S. Pat. No. 5,582,616 to Bolduc et al., which is also incorporated herein by reference in its entirety. Other examples of helical fasteners or screws and applicators are also shown in U.S. Pat. Nos. 5,810,882; 5,824,008; and 5,964,772; all to Bolduc et al., each of which is incorporated herein by reference in their entirety.
Gastric Reduction Tools and Methods Using Rotatable Devices
Aside from endoscopically applied stapling and clip devices, rotating and rotatable probes may also be used to form a modified smaller lumen within a main lumen. Such probes generally may be inserted into a stomach endoscopically and may engage a portion of the interior lining of the stomach and may then be rotated to roll the engaged portion of the stomach wall around the probe itself to bring the wall in apposition with another portion of the stomach wall. Such rotating probes may be used to create a blind-ended pouch of stomach within the main stomach lumen, or as with the other devices, may be used to create a smaller pouch exiting into the pylorus. Once the roll of stomach wall is brought into apposition, a row or a plurality of fasteners, e.g., staples, blind staples, clips, tags, adhesives, etc., may be used to maintain the stomach. The tubes themselves may be made of any variety of biocompatible materials which preferably have sufficient strength to undergo a torsional load, e.g., stainless steel, nickel, platinum, etc.
An example of a stomach modified by such a rotating probe or device is shown in FIG. 16A. Main pouch 300 is seen with modified pouch 302 formed along the lesser curvature of the stomach and delineated by junction 304. This example shows modified pouch 302 extending from esophagus 306 and terminating in pouch opening 308 proximally of pylorus 310. Pouch opening 308 may also be made to terminate at pylorus 310.
FIG. 16B shows a superior view from cross section 16B—16B from FIG. 16A of one variation on producing modified pouch 302 having modified lumen 314 from main pouch 300 having main lumen 312 where junction 304 may be formed by rotating the stomach upon itself. FIG. 16C shows an alternative superior view from cross section 16B—16B from FIG. 16A where modified pouch 302′ having modified lumen 314′ may be formed from main pouch 300′ having main lumen 312′. In this particular variation, junction 304′ may be formed by taking apposed sides of the interior stomach lining near the lesser curvature and approximating them to form modified lumen 314′.
Several examples of different possible variations on the rotating probe or device are shown and described below. These variations are not intended to be limiting but are merely given as illustrative examples.
FIG. 17A shows vacuum tube 320 which may have an elongate tubular body. Tube 320 may be inserted into a patient's stomach trans-esophageally via, e.g., an endoscope. Accordingly, distal end 322 is preferably rounded or gently tapered to be atraumatic to the patient. An opening or window 324 may be defined in the wall of tube 320 near distal end 322 and as seen in FIG. 17B, opening 324 is preferably in communication with lumen 326, which may run throughout tube 320. The geometry of opening 324 is preferably large enough to accommodate the invagination of tissue from the interior stomach lining by a vacuum created within lumen 326 and opening 324. The vacuum may be activated by the physician from a proximal end of tube 320 from outside of the patient. Once tissue is invaginated within window 324, a fastening member may be inserted and deployed to secure the interior stomach lining thereby reducing its overall volume, as described in further detail below. As shown in FIG. 17B, which is cross section 17B—17B from FIG. 17A, tube 320 preferably has a diameter and cross section which may approximate a final geometry of the newly created lumen within the stomach.
FIG. 18A shows an isometric view of another variation in counter-rotating tube 330. Counter-rotating tube 330 may have a gently tapered distal end 332 with an opening 334 defined in the tube wall near distal end 332. Preferably contained within tube 330 is an additional inner tube 336, which may be geometrically similar to tube 330 but with a diameter small enough to allow free rotation about the longitudinal axis preferably shared by both tubes 330 and 336. Inner tube 336 likewise may have inner opening 338, which may allow communication between lumen 340 and openings 334 and 338. As above, a vacuum may be activated from a proximal end of tube 330 to draw tissue from the interior stomach lining through lumen 340 and into openings 334 and 338 when they are aligned. As shown in FIG. 18B, which is cross section 18B—18B from FIG. 18A, once the tissue has become invaginated within openings 334, 338, inner tube 336 may be rotated to effectively pinch and firmly hold the tissue in place, as shown in FIG. 18B. The addition of the pinching action in addition to the vacuum may aid in holding the tissue, thereby aiding in the rotation of both tube 330 and inner tube 336 when forming the modified lumen. Both tubes 330 and 336 may be manipulated and rotated from a proximal end of the tubes from outside of the patient.
FIG. 19A shows an isometric view of another variation in barbed tube 350. Tube 350 may be similar to vacuum tube 320 described above. Distal end 352 is preferably tapered and opening 354 may be defined in the wall of tube 350 near distal end 352. Additionally, at least one and preferably several attachment points 356, e.g., tines, barbs, or hooks, may be defined along at least a single edge around opening 354. Attachment points 356 are preferably defined along the leading edge of opening 354 for rotation of tube 350. FIG. 19B, which is cross section 19B—19B from FIG. 19A, shows opening 354 preferably in communication with lumen 358 and a preferred orientation of attachment point 356.
FIG. 20A shows an isometric view of yet another variation in split tube 360. Split tube 360 may be formed of at least two splittable halves, e.g., first half 364 and second half 366, which may be joined together longitudinally along split 370. When first half 364 and second half 366 are joined together, split tube 360 preferably forms a tapered distal end 362. Split tube 360 may also define a lumen 372 which may run throughout the length of split tube 360. This variation may also comprise at least one and preferably several attachment points 368 on each of first half 364 and second half 366. As shown in the figure, first half 364 may have a row of attachment points 368 preferably aligned along a portion of split 370 and second half 366 may likewise have a row of attachment points 368 juxtaposed and preferably mirroring those located on first half 364. Attachment points 368 may be of any type described above and the number and positioning of attachment points 368 may depend upon the desired length of the resulting junction formed upon rolling the stomach. FIG. 20B, which is cross section 20B—20B from FIG. 20A, shows split 370 and an example of the juxtaposed relationship of attachment points 368.
FIG. 21 shows an example of a rotatable probe device during insertion into stomach 380. As seen, tube 384 may be inserted into stomach 380 via esophagus 382, preferably endoscopically. Tube 384 may be any of the devices described above and is shown generally as an example of how such devices may be inserted into an organ, e.g., stomach 380. As tube 384 is inserted, it may engage a portion of the interior of stomach 380, preferably along lesser curvature 386. The engagement may be accomplished by any of the methods described herein, e.g., attachment points partially piercing the stomach lining, a vacuum adhering a portion of the lining, etc. Once engaged, tube 384 may then be rotated to roll the engaged portion of the stomach wall around the probe itself to bring the wall in apposition with another portion of the stomach wall.
FIG. 22A shows a variation on partial cross section 22/2322/23 from FIG. 21 with tube 350 from FIGS. 19A and 19B in a preferred operation. As shown, interior lining 390 may be adhered to tube 350 via a vacuum created in opening 354 through lumen 358 and/or via attachment points 356 which may partially pierce lining 390, as described above. The location for adhering tube 350 may also be determined or aided by the use of marking device 40, as described above. Once the desired location of interior lining 390 has been established, tube 350 may be rotated about its longitudinal axis, following the arrow as shown, by at least about 180° and preferably at least about 360°. Lining 390 is preferably rotated until the adhered portion contacts a second portion of lining 390 to result in the modified lumen 314 of FIG. 22B, also shown in FIG. 16B. Once modified lumen 314 has been formed, fasteners may be fired or deployed through opening 354 or via a separate endoscopic stapling device at location 392 to secure and maintain modified lumen 314. Fasteners may comprise any of the fasteners as described herein, e.g., staples. Once modified lumen 314 has been secured, tube 350 may then be removed. FIG. 16B shows newly created modified pouch 302 with modified lumen 314 and, as seen, interior lining 390 also forms the interior surface defining modified lumen 314.
FIGS. 23A to 23D show another variation on partial cross section 22/2322/23 from FIG. 21 with split tube 360 from FIGS. 20A and 20B. Split tube 360 may be inserted into the stomach either as separate halves 364, 366 individually or as a whole tube which may then be split while in the stomach. Once separated, first half 364 and second half 366 may be engaged to interior lining 390 by attachment points 368 at a slight distance from one another. The separation distance may be determined by the desired resulting size of the lumen. Alternatively, the separation distance may be determined or aided by the use of marking device 40, as described above.
Once first half 364 and second half 366 have engaged interior lining 390, as shown in FIG. 23A, each of free ends 394 of halves 364, 366 may then be rotated in the direction of the arrow, as shown. Free ends 394 may be configured to simply contact each other or to interlock with each other and rotate about a hinge or pivot. As first half 364 and second half 366 continue to be rotated, FIGS. 23B and 23C show the progression of lumen formation as attachment points 368 draw around and towards one another. Finally in FIG. 23D, as split tube 360 is preferably formed again, modified lumen 314′ may be formed, as also shown in FIG. 16C, to then be secured or maintained preferably by fasteners, e.g., staples, which may be deployed through junction 304′.
A further variation on a rotating device is shown in the isometric view of dual tube device 400 shown in FIG. 24A. Dual tube device 400 may have at least two elongate members, first member 402 and second member 404, which may be rotatingly attached to controlling device 406 and may be parallel to each other. The members 402, 404 are preferably counter-rotating and may be rotated by a rotation control 408, which is preferably located on controlling device 406. First member 402 may have first distal end 410 offset slightly from the longitudinal axis of first member 402 by first bend 412. First opening 414 is also preferably defined in the wall of first member 402 proximally of first distal end 410. Second member 404 is preferably similar to first member 402 and may have second distal end 416 offset slightly from the longitudinal axis of second member 404 by second bend 418. Near second distal end 416, second opening 420 may be defined in the wall of second member 404.
FIG. 24B shows end view 24B—24B from FIG. 24A. Distal ends 410, 416 are seen as preferably being parallel and mirror images of one another. Also, the preferable counter-rotating action may be seen by the directional arrows. FIG. 24C shows cross section 24C—24C from FIG. 24A. As shown, the relationship between first and second opening 414, 420, respectively, and first and second lumen 422, 424, respectively, may be seen in the figure. Lumens 422, 424 preferably run through the length of members 402, 404, respectively, and are in communication with openings 414, 420. A vacuum may be created in openings 414, 420 through lumens 422, 424, respectively, from the controlling device 406. In operation, members 402, 404 may be inserted trans-esophageally into a patient's stomach. A vacuum may then be created in first and second openings 414, 420 to engage a portion of the stomach interior lining. Once engaged, a modified pouch may be created from the interior lining in much the same manner as described for FIGS. 23A to 23D, except the individual counter-rotating members 402, 404 do not form a split tube. The operation of the vacuum application and counter-rotation may be controlled through controlling device 406 which is preferably located outside the patient's body.
FIG. 25A shows yet another variation in vacuum device 432 shown inserted into stomach 430. Vacuum device 432 may be an endoscopic device inserted trans-esophageally into stomach 430 through esophagus 434. Device 432 may have vacuum member 438 and at least two grasping members 440, preferably disposed on either side of vacuum member 438. Once device 432 has been introduced into stomach 430, vacuum member 438 may be steered towards a desired area of interior lining 442, as seen in FIG. 25B which is a cross section view of device 432 attached to stomach interior lining 442. The desirable area of interior lining 442 may be located along greater curvature 436 or alternatively along lesser curvature 444, depending upon the desired results. In position, a vacuum may be activated in member 438 to draw a portion of interior lining 442 preferably between grasping members 440. As lining 442 is adhered to vacuum member 438, grasping members 440 may be used to pinch and grasp the drawn portion of lining 442. Then, device 432 may be rotated in the direction of the arrow indicated in FIG. 25C to result in the formation of a modified lumen. Afterwards, grasping members 440 may be locked in place, disengaged from device 432, and left as an implant. Alternatively, lining 442 may be fastened to maintain the created lumen by any of the methods described herein and grasping members 440, along with the rest of device 432, may be removed from stomach 430.
Gastric Reduction Tools and Methods Using Volume Reduction Devices
Aside from the use of rotating and rotatable probes, gastric volume reduction devices may also be used as part of the present invention. Such volume reduction devices generally may be inserted into a stomach trans-esophageally through the use of, e.g., an endoscope. The reduction device may be used to draw or engage a portion of the interior lining of the stomach; the drawn or engaged portion may then be eventually removed, either actively or through natural processes.
Several examples of different possible variations on the gastric volume reduction devices are shown and described below. These variations are not intended to be limiting but are merely given as illustrative examples.
FIG. 26 shows an isometric view of a variation on the gastric volume reduction device in concentric tube device 450. Device 450 may have inner tube 452 defining lumen 454, which preferably runs throughout inner tube 452. Pusher sleeve 456 may be disposed concentrically over inner tube 452 such that pusher sleeve 456 may be allowed to slide freely along inner tube 452. Pusher sleeve 456 is also preferably disposed over inner tube 452 such that the distal end of inner tube 452 is open to allow ring 458 to be rolled or stretched onto the distal end. Ring 458 is preferably made of an elastic type material which would allow ring 458 to elastically cinch onto inner tube 452.
During use, FIG. 27A shows a view of concentric tube device 450 within stomach 460 preferably inserted through esophagus 462. The distal end of device 450, particularly inner tube 452, may be brought into position near a location of interior surface 464 where tissue may be desirably removed. As shown in FIG. 27B, once device 450 is in place, a vacuum may be actuated within lumen 454. The vacuum may then draw a portion of withdrawn lining tissue 466 up into lumen 454, as seen in the cross section of device 450. While lining tissue 466 is held within lumen 454, pusher sleeve 456 may be pushed or urged distally along inner tube 452. As pusher sleeve 456 advances, it may also push or urge elastic ring 458 distally along inner tube 452 until ring 458 is pushed entirely off the distal end of inner tube 452 and onto a portion of lining tissue 466, as seen in FIG. 27C. Device 450 may then be removed from stomach 460 after ceasing the vacuum, thereby leaving lining tissue 466 with elastic ring 458. After time, as seen in FIG. 27D, pressure necrosis may cause lining tissue 466 and ring 458 to simply fall off from the rest of interior surface 464 to be passed normally through the rest of the patient's body. The action of drawing up and removing a portion of interior surface 464 may effectively reduce the overall volume of stomach 460, thereby reducing the available volume for the ingestion of foods. As such, this procedure may be repeated several times either sequentially or simultaneously until the overall volume of stomach 460 is reduced to a desirable volume depending upon the desired results.
FIG. 28 shows another variation on the gastric volume reduction device. As shown, an endoscope 474 preferably having grasping device 476, e.g., biopsy forceps, may be inserted into stomach 472. A ligating apparatus, e.g., ring stapler, zip tie, etc., either as part of endoscope 474 or as a separately introduced ligation device 478, is preferably also introduced within stomach 472. Forceps 476 and ligation device 478 may be used in conjunction with one another by, e.g., having forceps 476 grasp withdrawn tissue 480 and then having ligation device 478 tie or ligate tissue 480. Forceps 476 may then be used to excise and remove withdrawn tissue 480 above ties 482 to reduce the overall stomach volume. An example of a jaw structure which may be utilized is shown and described in U.S. Pat. No. 5,749,893 to Vidal et al., which is incorporated herein by reference in its entirety. Alternatively, ligated withdrawn tissue 480 may be left attached to stomach 470 to be removed naturally by pressure necrosis. Several excisions may be performed in reducing stomach volume from, e.g., stomach 472 (as shown by the dashed lines) down to a final reduced stomach 470.
FIG. 29A shows yet another variation with tractive rollers 490. This device may have at least two rigid rollers 492, which are preferably elongated, connected to one another preferably at both ends by, e.g., elastic members 494. The connection of rollers 492 may create channel 496 therebetween through which tissue may be drawn. FIG. 29B shows rollers 492 with a portion of stomach interior surface 498 being drawn through channel 496 by a grasping device, e.g., forceps 500. Meanwhile, rollers 492 may be maintained within the stomach by, e.g., retaining forceps 502, which may be used to hold rollers 492 relative to interior surface 498. Elastic members 494 may pinch rollers 492 together, thereby creating a zone of pressure necrosis in withdrawn interior surface 498. Also, as interior surface 498 is drawn up through channel 496, rollers 492 may contain a ratcheting device within to prevent surface 498 from rolling out back through channel 496. Once the desired amount of surface 498 has been drawn, it may either be excised or simply left to be removed naturally by necrosis. FIG. 29C shows an alternative variation with ratcheted rollers 504. Ratcheted rollers 504 may be operated in the same manner as described for rollers 492 but they preferably have a tractive surface to enhance traction between the tissue and the rollers 504. Torquing device 506 may be used with ratcheted rollers 504 and may be introduced into the stomach endoscopically to mesh with one of rollers 504 for the purpose of causing it to rotate. Moreover, either rollers 492 or ratcheted rollers 504 may be used simply to gather stomach surface tissue to allow for fastening, e.g., suturing, stapling, etc.
Pyloroplasty Tools and Methods
Creating a smaller gastric pouch within the stomach may be accomplished by a variety of methods, as described above. To aid in the overall effect for the treatment of obesity, a pyloroplasty procedure may also be performed to enhance treatment. The pyloroplasty may be performed prior to (preferable), in conjunction with, or following the gastric reduction procedure. A pyloroplasty procedure typically results in the pyloric sphincter being rendered incompetent. However, in the case of treatments for GERD using the devices and methods described above, the pyloroplasty procedure as described herein may be omitted. Conventional pyloroplasty procedures may typically be performed surgically or through the use of standard peripheral angioplasty balloons, e.g., in the 7 mm range. However, in order to render a relatively healthy and normal pylorus permanently incompetent, a more aggressive procedure may be needed.
To accomplish this generally, a pyloroplasty device may be passed endoscopically through the esophagus, into the stomach, and preferably into position in or across the pylorus. Energy or a stimulus is then preferably applied to the pylorus to render it incompetent. Energy may be in the form of, e.g., heat, electrical, chemical, RF, etc., or a combination. Examples of chemical energy stimulus may comprise alcohol and sotrodecol. The stimulus may be in the form of, e.g., dilatation, cutting, ablation, viral, etc., or a combination. An example of a viral or chemical stimulus may be, e.g., a poison such as the botulinum toxin type A virus (Botox). An example of a method of use for Botox is described in U.S. Pat. No. 5,437,291 to Pasricha et al., which is incorporated herein by reference in its entirety. An incompetent pylorus may allow stomach contents to drain directly into the proximal duodenum with minimal resistance. Moreover, some of the mentioned pyloroplasty treatments may be selected or designed to last only for a specific time period, e.g., a week or several months, etc. For instance, the effects of simple dilatation or the injection of Botox may be designed to render the pylorus incompetent for only a few months, which may be a desirable time period for the patient to obtain the desired results of the procedure.
Several examples of different possible variations on pyloroplasty devices are shown and described below. These variations are not intended to be limiting but are merely given as illustrative examples.
FIG. 30 shows an isometric view of one variation of a dilatation device in balloon device 510 which may have angioplasty balloon 512 located near or at the distal end of catheter 514. Angioplasty balloon 512 may be used alone to simply dilate the pylorus. Alternatively, exterior balloon surface 516 may have at least one and preferably several stimulating members 518 disposed about surface 516. Stimulating members 518 are shown in the figure as cutting blades or wires, but alternatively, they may include electrodes, cryogenic dispensing probes or members, chemical dispensing probes, etc. Moreover, balloon 512 may alternatively be a dilation wire basket similarly disposed with stimulating members 518.
FIG. 31 shows an isometric view of another variation in probe device 520. Device 520 may have catheter or delivery member 524 with, e.g., probes 526, which may extend from distal end 522. Although three probes 526 are shown in the figure, at least one and up to several probes of varying thickness and lengths may be used. Probes 526 may be retractable so that during delivery through, e.g., the esophagus or stomach, probes 526 may be withdrawn within distal end 522 and then extended when treating the pylorus. Probes 526 may be electrically connected to a voltage or power source located outside the patient's body to deliver electrical, RF, or heat energy to the pylorus. Alternatively, they may be configured like a needle to deliver chemical or biological stimuli to render the pylorus incompetent. For example, probes 526 may be used to inject chemicals, e.g., alcohol, sotrodecol, or other ablative chemicals, or biological stimuli, e.g., Botox virus or some other incapacitating virus, into the pylorus. Such stimulants may be carried within distal end 522, delivery catheter 524, or they may also be delivered from the proximal end of catheter 524 and injected through to probes 526.
Other variations which may be used for the pyloroplasty procedure are shown in FIGS. 32A and 32B. FIG. 32A shows sphincterotome arm 530 having a distal end 532. Arm 530 may be bent as shown to allow cutting member 534 to be drawn between distal end 532 and a location proximal of distal end 532 along arm 530. Another variation is seen in FIG. 32B where delivery member 536 may have an arcuate support member 538 to support cutting member 540. The variations shown in FIGS. 32A and 32B may be delivered via a catheter or endoscope trans-esophageally and through the stomach to the pylorus where either cutting member 534, 540 may be used to cut or saw into the tissue in or around the pylorus to render it incompetent. These particular variations of sphincterotomes shown in FIGS. 32A and 32B may be manufactured by Medi-Globe Corporation, located in Tempe, Ariz.
FIG. 33 shows stomach 550 with a distal portion of the wall of the lesser curvature removed for clarity. Device 520 may be delivered through esophagus 552 to a location proximal of pylorus 558, e.g., first position 554. If probes 526 were retracted during delivery, they may then be extended, as shown. Distal end 522 of device 520 may be advanced to, e.g., second position 556, such that probes 526 may pierce pylorus 558 to deliver the stimulus.
FIG. 34A shows an isometric view of another variation with combination device 560. Device 560 may have housing 562 on the distal end of delivery catheter or endoscope 564. Housing 562 defines notch 566 which may be oriented perpendicularly relative to the longitudinal axis defined by endoscope 564. Notch 566 preferably has a geometry large enough to accommodate part of pylorus 558 and housing 562 may be tapered at its distal end to allow for easy insertion into the pylorus 558 during the procedure. Within notch 566 may be cutting blade 568 and on either side of blade 568 may be fasteners 570, e.g., individual anchors, staples, etc. In operation, FIG. 34B shows housing 562 and endoscope 564 delivered through esophagus 552. The wall of stomach 550 is partially cut away for clarity. Housing 562 may be inserted into pylorus 558, then notch 566 is preferably aligned such that part of the pyloral sphincter lies within notch 566. Alternatively, the pyloral tissue may also be drawn into notch 566 via a vacuum or grasping member. Once the pyloral tissue is within notch 566, cutting blade 568 may be actuated to traverse notch 566 and sever part of the tissue of pylorus 558. Fasteners 570 may then be deployed on either side of incision 572 to affix the incised tissue. The number of incisions 572 may vary depending upon the desired degree of pyloric disablement. Alternatively, an inflatable balloon may be attached on the back of notch 566 and inflated to push housing 562 into apposition with pylorus 558 and cause invagination of the tissue into notch 566.
Anastomosis Tools and Methods
In addition to the tools and methods described above for gastric reduction and pyloroplasty procedures, an additional anastomosis gastric bypass procedure may also be performed to further enhance treatment. The anastomosis procedure may be performed preferably prior to, in conjunction with, or following the gastric reduction and pyloroplasty (if performed at all) procedures. In the case of treatments for GERD using the devices and methods described above, the anastomosis procedure as described herein may be omitted. The procedure generally involves endoscopically or laparoscopically creating a side-to-side anastomosis preferably from within the stomach and bowel and within the digestive tract. This procedure may be similar to the Roux-en-Y gastric bypass (RYGB) procedure but with minimal trauma. This procedure may also effectively bypass food from the stomach, past a proximal portion of the bowel, and preferably directly into a lower portion of the bowel. This bypassed portion may be considered a malabsorption zone.
A representative and normal gastrointestinal system of a person is shown in FIG. 35 for comparison. Stomach 580 is shown with pyloric sphincter 582 near gallbladder 584 and attached to the proximal section of duodenum 586. The distal section of duodenum 586 is attached to the proximal section of jejunum 588, the distal section of which is further attached to the proximal section of ileum 590. Ileum 590 is then attached to ascending colon 592, which continues through to the transverse colon (which has been removed for clarity), and then to descending colon 594 and finally to rectum 596.
A gastro-intestinal system which may be modified by a preferable anastomosis procedure is shown in FIG. 36. Stomach 600 is shown in this variation as having been modified by creating modified pouch 602, which may be created by any of the methods and tools as described above. Esophagus 603 is preferably connected to a proximal end of pouch 602. As described above, the distal end of pouch 602 may be connected directly to pylorus 604 or alternatively, may be a blind-ended pouch and pylorus 604 is connected to the proximal end of duodenum 606. A first anastomosis 608 may be created preferably between modified pouch 602 and a section of digestive tract either from the distal duodenum 606 or proximal jejunum 610. First anastomosis 608 may be located in a range from about 20 to 50 cm from pylorus 604. A second anastomosis 614 may be created preferably between a section of duodenum 606 and a section of ileum 612. The second anastomosis 614 may be located in a range from about 15 to 55 cm from pylorus 604 or about 150 to 200 cm down along the length of the small intestines from pylorus 604. This procedure may allow for drainage of secretions created by stomach 600 to pass through pylorus 604 and secretions of bile and chyme from the pancreas and gallbladder 618 to pass through biliary duct 620 partly through duodenum 606 and then through second anastomosis 614 and directly into distal ileum 616 and out of the body. The bypassed stomach 600, pylorus 604, and proximal duodenum 606 may act as a malabsorption zone because sugars and fats which might normally be mostly absorbed in this zone may now be directly passed into the distal duodenum 606 or proximal jejunum 610.
During the anastomosis procedure, both first and second anastomoses 608, 614, respectively, may be created first. Duodenum 606 may then be closed off between the two anastomoses 608, 614. Then, depending upon the length and size of the resulting modified stomach 602, pylorus 604 may be closed off or left open, depending upon the desired result and which of procedures and tools are implemented. Finally, modified pouch 602 may be created after the anastomoses procedures. Alternatively, modified pouch 602 may be created prior to the anastomoses procedures, again depending upon the desired result and which of procedures and tools are implemented. If modified pouch 602 were created first, then the anastomoses procedure may be reversed to essentially end with the same result.
A conventional RYGB procedure is generally performed through a 6-8 inch incision extending from the end of the breastbone to just above the navel. However, the procedure described above may be performed entirely endoscopically or laparoscopically. FIG. 37 shows an isometric view of an assembly which may be utilized to achieve part of the procedure. Deployment device 630 may have anastomosis assembly 632 preferably connected by steerable length 634 to manipulation handle 636. Assembly 632 may be steerable during insertion, preferably trans-esophageally and through the stomach, by steering grip 638 which may be located on manipulation handle 636. Control by a physician or surgeon of manipulation handle 636 may be facilitated by handle 640.
Anastomosis assembly 632 may have stapler housing 644 configured to fit intimately with distal element 646 preferably by a magnetic force, the use of which is described below. Distal element 646 is preferably tapered or rounded on one side and may have a coring anvil 648 on its opposing side. Coring anvil 648 may be tapered or rounded and may fit intimately into coring mate 650 which is preferably located near or at the center of stapler housing 644. Stapler housing 644 may also house several staples loaded within staple slots 652, which may be disposed circumferentially around coring mate 650 and may be actuated from the proximal end of length 634 by staple trigger 642.
FIG. 38 shows a cross sectioned view of anastomosis assembly 632 mated with distal element 646 at first anastomosis 608 between modified pouch 602 and jejunum 610. Part of the walls of modified pouch 602 and jejunum 610 have been removed for clarity. In creating first anastomosis 608, distal element 646 may first be placed within the appropriate section of jejunum 610. This may be done by orally passing distal element 646 through the esophagus, stomach, and then through the duodenum. Distal element 646 is preferably magnetized, either by manufacturing distal element 646 from natural ferrous materials or artificially magnetizing it. Because of the magnetization, distal element 646 may be urged through the body and into place within the duodenum by, e.g., magnetic wands or magnetic pickups, which may be manipulated from outside the patient's body.
During or after placement of distal element 646, stapler housing 644, which may be attached to steerable length 634, may be introduced trans-esophageally into the stomach 602 and placed into position along stomach wall 660 at the desired site of first anastomosis 608. Once both stapler housing 644 and distal element 646 are in position, they may then be coupled together preferably by the magnetic force and attraction between the two. Moreover, the two may be brought into alignment either by alignment grooves (not shown) or by the mating of coring anvil 648 into coring mate 650. As the mating occurs, part of stomach wall 660 and intestinal wall 662 are preferably held or maintained between stapler housing 644 and distal element 646. To enhance the mating, fasteners may optionally be deployed from stapler housing 644 through staple slots 652 and preferably through both stomach wall 660 and intestinal wall 662 into distal element 646. FIG. 38 shows staples 667 deployed as fasteners, but they may comprise any type of mechanical fasteners as described above, as well as, e.g., grommet-type swages, snap lock fits, staples, screws, clips, and friction-fittings.
Once the fitting has been accomplished, the device may be left in apposition to maintain the position of stomach wall 660 and intestinal wall 662 for about one week. This may result in pressure necrosis of the tissue between stapler housing 644 and distal element 646 preferably causing the serosal layers of the gut to fuse, at which point the assembly may drop out and be passed, preferably leaving first anastomosis 608 behind. Alternatively, a coring device 664, which may be slidingly contained within stapler housing 644, may first be advanced through the center of stapler housing 644 and both stomach wall 660 and intestinal wall 662 to create first anastomosis 608. The remaining assembly may then be left to cause the pressure necrosis and fusing of tissue, as described. Another alternative may be to use stapler housing 644 and distal element 646 as a mechanism for a conventional end-to-end anastomosis (EEA) stapler. In this case, once they are aligned, a rod may be advanced through the center of the assembly to preferably lock distal element 646 to intestinal wall 662. The rod may be drawn back, preferably pulling a distal stapler segment into stapler housing 644. This action may cause staples to fire and a circumferential blade to cut out the center of the staple ring, thereby creating an anastomosis.
To create second anastomosis 614, a similar approach may be taken as for creating first anastomosis 608. An example of another magnetic anastomosis device which may also be used in this procedure is shown and described in U.S. Pat. No. 5,690,656 to Cope et al., which is incorporated herein by reference in its entirety. FIG. 39 shows a portion of duodenum 606 juxtaposed to a portion of ileum 612 and distal ileum 616 with part of the intestinal walls removed for clarity. In this variation, proximal element 670 may be used and is preferably a magnetized mating element for distal element 646. Distal element 646 may first be urged to the desired location preferably in ileum 612 by, e.g., magnetic wands or magnetic pickups, which may be manipulated from outside the patient's body, in the same manner as above. During or after placement of distal element 646, proximal element 670 may also be delivered or urged to the desired location in the same manner. Once both elements 646, 670 are in position, they are preferably mated together by a magnetic force. The mating may optionally be enhanced by fasteners, e.g., staples 667, to hold both elements 646, 670 in position. The intestinal wall inbetween may be cored, as described above, but it may also be simply left to undergo pressure necrosis between elements 646, 670 eventually causing the serosal layers of the gut to fuse, at which point elements 646, 670 may drop out and be passed, preferably leaving second anastomosis 614 behind.
The applications of the methods and tools discussed above are not limited to the treatment of obesity, but may include any number of further applications, e.g., GERD, which may involve manipulation of an organ interior. Modification of the above-described methods and tools for carrying out the invention, and variations of aspects of the invention that are obvious to those of skill in the art are intended to be within the scope of the claims.

Claims (54)

We claim:
1. A device for reducing an interior volume of an organ comprising:
a tissue adhering member having a proximal end and a distal end with a length therebetween, the member having at least two releasably adherable regions for releasably positioning via a vacuum a first area of the interior near a second area of the interior,
wherein the interior volume of the organ is reduced upon fastening the first area to the second area such that communication with the interior volume is maintained.
2. The device of claim 1 wherein the first area is positioned adjacent to the second area.
3. The device of claim 1 wherein the first area is in apposition to the second area.
4. The device of claim 1 wherein the tissue adhering member defines a slot along the length, the slot being adapted to receive a retractable septum.
5. The device of claim 4 wherein the retractable septum defines at least one surface adapted to abrade an adjacent portion of the interior.
6. The device of claim 5 wherein the adjacent portion of the interior surface is abraded by the retractable septum using a method selected from the group consisting of cutting, scoring, heating, freezing, and chemical ablation.
7. The device of claim 1 wherein each of the two releasably adherable regions are separated by an angle between about 20° to 180° about a longitudinal axis defined by the length.
8. The device of claim 7 wherein the two releasably adherable regions are separated by an angle between about 90° to 180°.
9. The device of claim 1 wherein the first area and the second area are adhered to the tissue adhering member via the vacuum created in each of the two releasably adherable regions.
10. The device of claim 9 wherein each of the two releasably adherable regions are in fluid communication with a common channel defined within the tissue adhering member.
11. The device of claim 1 further comprising a delivery member having a proximal end and a distal end with a length therebetween, the tissue adhering member being attached to the distal end of the delivery member.
12. The device of claim 11 wherein the tissue adhering member is in fluid communication with the proximal end of the delivery member.
13. The device of claim 1 wherein the length of the tissue adhering member is straight.
14. The device of claim 1 wherein the length of the tissue adhering member defines an arc.
15. The device of claim 1 wherein a geometry of the tissue adhering member is adjustable.
16. The device of claim 1 wherein the distal end of the tissue adhering member flares away from a curvature of the organ.
17. The device of claim 1 wherein the organ comprises a stomach.
18. The device of claim 17 wherein the tissue adhering member is adapted to be inserted into the stomach endoscopically via an esophageal passageway.
19. The device of claim 1 further comprising at least one fastener disposable within the tissue adhering member for fastening the first area to the second area.
20. The device of claim 19 further comprising a wedge slidingly disposed within an interior channel defined by the tissue adhering member, the wedge being adapted to urge the fastener from an open first configuration to a closed second configuration.
21. The device of claim 20 further comprising a wire attached to the wedge.
22. The device of claim 19 wherein the fastener comprises a mechanical fastener selected from the group consisting of C staples, U staples, clips, and tags.
23. The device of claim 19 wherein the fastener comprises a screw having a helical shape.
24. The device of claim 23 wherein a diameter of a distal end of the screw is larger than a diameter of a proximal end of the screw.
25. The device of claim 24 wherein a length between the distal end of the screw and the proximal end of the screw is tapered.
26. The device of claim 23 wherein at least two coils at a distal end of the screw each comprise a diameter which is equal.
27. The device of claim 23 wherein a distal end of the screw is configured to pierce tissue.
28. The device of claim 23 wherein the screw is at least partially covered with securing members.
29. The device of claim 28 wherein the securing members are selected from the group consisting of barbs and whisker-like filaments.
30. The device of claim 23 wherein the screw comprises a bioabsorbable or biocompatible material.
31. The device of claim 30 wherein the bioabsorbable or biocompatible material is selected from the group consisting of polymers and superelastic alloys.
32. The device of claim 23 wherein the screw is configured to alternatingly pierce a first area of tissue and a second area of tissue while approximating the first area of tissue and the second area of tissue together.
33. The device of claim 19 further comprising a plurality of additional fasteners, each of the fasteners being configured to fasten the first area to the second area while juxtaposed linearly to form a continuous fixation line.
34. A method for reducing an interior volume of an organ comprising:
releasably adhering a first area of the interior to a tissue adhering member via a vacuum;
releasably adhering a second area of the interior to the tissue adhering member via the vacuum such that the first area is positioned near the second area; and,
fastening the first area to the second area such that communication with the interior volume is maintained, thereby reducing the interior volume of the organ.
35. The method of claim 34 wherein the first area and the second area are releasably adhered to the tissue adhering member via the vacuum created in at least two releasably adherable regions defined in the tissue adhering member.
36. The method of claim 34 wherein the first area is positioned adjacent to the second area.
37. The method of claim 34 wherein the first area is in apposition to the second area.
38. The method of claim 34 wherein releasably adhering a second area of the interior surface to the tissue adhering member such that the first area is positioned near the second area further comprises removing a septum disposed in the tissue adhering member such that the first area contacts the second area.
39. The method of claim 34 further comprising inducing a healing response in the first area or the second area.
40. The method of claim 38 further comprising abrading the first area or the second area while removing the septum.
41. The method of claim 39 wherein inducing a healing response in the first area or the second area comprises a method selected from the group consisting of cutting, scoring, heating, freezing, and chemical ablation.
42. The method of claim 34 wherein fastening the first area to the second area further comprises sliding a wedge disposed within an interior channel defined by the tissue adhering member such that the wedge urges a mechanical fastener to cinch the first area to the second area.
43. The method of claim 34 wherein the fastener is selected from the group consisting of C staples, U staples, clips, and tags.
44. The method of claim 34 further comprising disengaging the first area and the second area from the tissue adhering member.
45. The method of claim 34 wherein the organ comprises a stomach.
46. The method of claim 45 wherein the tissue adhering member is endoscopically inserted into the stomach via an esophageal passageway prior to releasably adhering a first area of the interior to a tissue adhering member.
47. The method of claim 34 wherein fastening the first area to the second area creates a boundary between a lumen, formed by the fastened first area and second area, and a remaining portion of the organ.
48. The method of claim 47 wherein the boundary is straight.
49. The method of claim 47 wherein the boundary approximates a curvature of the organ.
50. The method of claim 47 wherein the boundary is adjustable.
51. The method of claim 47 wherein the boundary flares towards the remaining portion of the organ.
52. The method of claim 34 wherein fastening the first area to the second area to reduce the volume of an interior organ further comprises urging a fastener through an interior channel defined in the tissue adhering member to fasten the first area and the second area together.
53. The method of claim 52 wherein the fastener has a tapering helical shape with a piercing end.
54. The method of claim 52 wherein urging the fastener through the interior channel comprises rotating the fastener about a longitudinal axis defined by the fastener such that the first area and the second area cinches together.
US09/871,297 2001-05-30 2001-05-30 Obesity treatment tools and methods Expired - Lifetime US6558400B2 (en)

Priority Applications (33)

Application Number Priority Date Filing Date Title
US09/871,297 US6558400B2 (en) 2001-05-30 2001-05-30 Obesity treatment tools and methods
US10/155,362 US7083629B2 (en) 2001-05-30 2002-05-23 Overtube apparatus for insertion into a body
BRPI0210900-0A BR0210900B1 (en) 2001-05-30 2002-05-29 device for reducing the interior size of a stomach.
CA002448961A CA2448961A1 (en) 2001-05-30 2002-05-29 Obesity treatment tools and methods
PCT/US2002/017077 WO2002096327A2 (en) 2001-05-30 2002-05-29 Obesity treatment tools and methods
EP02739531A EP1389984B1 (en) 2001-05-30 2002-05-29 Obesity treatment tools
ES02739531T ES2321487T3 (en) 2001-05-30 2002-05-29 TOOLS FOR TREATMENT OF OBESITY.
MXPA03010987A MXPA03010987A (en) 2001-05-30 2002-05-29 Obesity treatment tools and methods.
AT02739531T ATE424790T1 (en) 2001-05-30 2002-05-29 DEVICES FOR TREATING OBESITY
DE60231489T DE60231489D1 (en) 2001-05-30 2002-05-29 DEVICES FOR TREATMENT OF GRAVITY
JP2002592844A JP4283546B2 (en) 2001-05-30 2002-05-29 Obesity treatment tools and methods
AU2002312174A AU2002312174B2 (en) 2001-05-30 2002-05-29 Obesity treatment tools and methods
US10/313,394 US7288099B2 (en) 2001-05-30 2002-12-05 Obesity treatment tools and methods
US10/342,623 US7288101B2 (en) 2001-05-30 2003-01-14 Obesity treatment tools and methods
US10/402,061 US7503922B2 (en) 2001-05-30 2003-03-27 Obesity treatment tools and methods
NO20035239A NO20035239D0 (en) 2001-05-30 2003-11-25 Devices and methods for treating obesity
US10/729,552 US8613749B2 (en) 2001-05-30 2003-12-05 Obesity treatment tools and methods
US10/729,622 US7510559B2 (en) 2001-05-30 2003-12-05 Obesity treatment tools and methods
JP2005156465A JP4268599B2 (en) 2001-05-30 2005-05-27 Obesity treatment tools and methods
US11/364,036 US7306614B2 (en) 2001-05-30 2006-02-28 Overtube apparatus for insertion into a body
AU2006230695A AU2006230695B2 (en) 2001-05-30 2006-10-19 Obesity treatment tools and methods
US11/654,783 US7862574B2 (en) 2001-05-30 2007-01-18 Obesity treatment tools and methods
US11/654,709 US7909838B2 (en) 2001-05-30 2007-01-18 Obesity treatment tools and methods
US11/716,902 US8075577B2 (en) 2001-05-30 2007-03-12 Obesity treatment tools and methods
US11/801,450 US8080022B2 (en) 2001-05-30 2007-05-10 Obesity treatment tools and methods
US11/801,449 US8137366B2 (en) 2001-05-30 2007-05-10 Obesity treatment tools and methods
US11/801,474 US8137367B2 (en) 2001-05-30 2007-05-10 Obesity treatment tools and methods
US11/801,475 US8080025B2 (en) 2001-05-30 2007-05-10 Obesity treatment tools and methods
US11/757,943 US8123765B2 (en) 2001-05-30 2007-06-04 Obesity treatment tools and methods
JP2008284886A JP2009078158A (en) 2001-05-30 2008-11-05 Obesity treatment tool and method
US13/029,075 US8419755B2 (en) 2001-05-30 2011-02-16 Obesity treatment tools and methods
US13/847,040 US8794243B2 (en) 2001-05-30 2013-03-19 Obesity treatment tools and methods
JP2013087257A JP5524387B2 (en) 2001-05-30 2013-04-18 Obesity treatment equipment

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US09/871,297 US6558400B2 (en) 2001-05-30 2001-05-30 Obesity treatment tools and methods

Related Child Applications (5)

Application Number Title Priority Date Filing Date
US10/155,362 Continuation-In-Part US7083629B2 (en) 2001-05-30 2002-05-23 Overtube apparatus for insertion into a body
US10/313,394 Division US7288099B2 (en) 2001-05-30 2002-12-05 Obesity treatment tools and methods
US10/342,623 Continuation US7288101B2 (en) 2001-05-30 2003-01-14 Obesity treatment tools and methods
US10/402,061 Continuation US7503922B2 (en) 2001-05-30 2003-03-27 Obesity treatment tools and methods
US11/364,036 Continuation-In-Part US7306614B2 (en) 2001-05-30 2006-02-28 Overtube apparatus for insertion into a body

Publications (2)

Publication Number Publication Date
US20020183768A1 US20020183768A1 (en) 2002-12-05
US6558400B2 true US6558400B2 (en) 2003-05-06

Family

ID=25357144

Family Applications (16)

Application Number Title Priority Date Filing Date
US09/871,297 Expired - Lifetime US6558400B2 (en) 2001-05-30 2001-05-30 Obesity treatment tools and methods
US10/313,394 Expired - Lifetime US7288099B2 (en) 2001-05-30 2002-12-05 Obesity treatment tools and methods
US10/342,623 Expired - Lifetime US7288101B2 (en) 2001-05-30 2003-01-14 Obesity treatment tools and methods
US10/402,061 Expired - Fee Related US7503922B2 (en) 2001-05-30 2003-03-27 Obesity treatment tools and methods
US10/729,622 Expired - Fee Related US7510559B2 (en) 2001-05-30 2003-12-05 Obesity treatment tools and methods
US10/729,552 Active 2025-06-18 US8613749B2 (en) 2001-05-30 2003-12-05 Obesity treatment tools and methods
US11/654,783 Expired - Lifetime US7862574B2 (en) 2001-05-30 2007-01-18 Obesity treatment tools and methods
US11/654,709 Active 2024-06-02 US7909838B2 (en) 2001-05-30 2007-01-18 Obesity treatment tools and methods
US11/716,902 Active 2024-12-03 US8075577B2 (en) 2001-05-30 2007-03-12 Obesity treatment tools and methods
US11/801,474 Active 2024-03-12 US8137367B2 (en) 2001-05-30 2007-05-10 Obesity treatment tools and methods
US11/801,449 Active 2024-05-26 US8137366B2 (en) 2001-05-30 2007-05-10 Obesity treatment tools and methods
US11/801,475 Active 2024-08-07 US8080025B2 (en) 2001-05-30 2007-05-10 Obesity treatment tools and methods
US11/801,450 Active 2024-07-04 US8080022B2 (en) 2001-05-30 2007-05-10 Obesity treatment tools and methods
US11/757,943 Active 2024-08-17 US8123765B2 (en) 2001-05-30 2007-06-04 Obesity treatment tools and methods
US13/029,075 Expired - Fee Related US8419755B2 (en) 2001-05-30 2011-02-16 Obesity treatment tools and methods
US13/847,040 Expired - Fee Related US8794243B2 (en) 2001-05-30 2013-03-19 Obesity treatment tools and methods

Family Applications After (15)

Application Number Title Priority Date Filing Date
US10/313,394 Expired - Lifetime US7288099B2 (en) 2001-05-30 2002-12-05 Obesity treatment tools and methods
US10/342,623 Expired - Lifetime US7288101B2 (en) 2001-05-30 2003-01-14 Obesity treatment tools and methods
US10/402,061 Expired - Fee Related US7503922B2 (en) 2001-05-30 2003-03-27 Obesity treatment tools and methods
US10/729,622 Expired - Fee Related US7510559B2 (en) 2001-05-30 2003-12-05 Obesity treatment tools and methods
US10/729,552 Active 2025-06-18 US8613749B2 (en) 2001-05-30 2003-12-05 Obesity treatment tools and methods
US11/654,783 Expired - Lifetime US7862574B2 (en) 2001-05-30 2007-01-18 Obesity treatment tools and methods
US11/654,709 Active 2024-06-02 US7909838B2 (en) 2001-05-30 2007-01-18 Obesity treatment tools and methods
US11/716,902 Active 2024-12-03 US8075577B2 (en) 2001-05-30 2007-03-12 Obesity treatment tools and methods
US11/801,474 Active 2024-03-12 US8137367B2 (en) 2001-05-30 2007-05-10 Obesity treatment tools and methods
US11/801,449 Active 2024-05-26 US8137366B2 (en) 2001-05-30 2007-05-10 Obesity treatment tools and methods
US11/801,475 Active 2024-08-07 US8080025B2 (en) 2001-05-30 2007-05-10 Obesity treatment tools and methods
US11/801,450 Active 2024-07-04 US8080022B2 (en) 2001-05-30 2007-05-10 Obesity treatment tools and methods
US11/757,943 Active 2024-08-17 US8123765B2 (en) 2001-05-30 2007-06-04 Obesity treatment tools and methods
US13/029,075 Expired - Fee Related US8419755B2 (en) 2001-05-30 2011-02-16 Obesity treatment tools and methods
US13/847,040 Expired - Fee Related US8794243B2 (en) 2001-05-30 2013-03-19 Obesity treatment tools and methods

Country Status (1)

Country Link
US (16) US6558400B2 (en)

Cited By (371)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20020193816A1 (en) * 1999-06-22 2002-12-19 Ndo Surgical, Inc., A Delaware Corporation Tissue reconfiguration
US20030040808A1 (en) * 2001-08-27 2003-02-27 Stack Richard S. Satiation devices and methods
US20030065359A1 (en) * 2001-05-30 2003-04-03 Gary Weller Overtube apparatus for insertion into a body
US20030078611A1 (en) * 2001-05-17 2003-04-24 Kiyoshi Hashiba Intragastric device for treating obesity
US20030191479A1 (en) * 2002-04-03 2003-10-09 Thornton Sally C. Body lumen closure
US20030199989A1 (en) * 2001-08-27 2003-10-23 Stack Richard S. Satiation devices and methods
US20040009224A1 (en) * 2000-08-11 2004-01-15 Miller Larry S Obesity controlling method
US20040024386A1 (en) * 2001-05-30 2004-02-05 Deem Mark E. Obesity treatment tools and methods
US20040037865A1 (en) * 2000-08-11 2004-02-26 Miller Larry Sherwin Obesity controlling method
US20040082963A1 (en) * 2002-10-23 2004-04-29 Jamy Gannoe Method and device for use in endoscopic organ procedures
US20040093091A1 (en) * 2002-08-07 2004-05-13 Jamy Gannoe Intra-gastric fastening devices
US20040089313A1 (en) * 1998-02-19 2004-05-13 Curon Medical, Inc. Systems and methods for treating obesity and other gastrointestinal conditions
US20040092892A1 (en) * 2002-11-01 2004-05-13 Jonathan Kagan Apparatus and methods for treatment of morbid obesity
US20040107004A1 (en) * 2002-12-02 2004-06-03 Seedling Enterprises, Llc Bariatric sleeve
US20040117031A1 (en) * 2001-08-27 2004-06-17 Stack Richard S. Satiation devices and methods
US20040133238A1 (en) * 1999-06-22 2004-07-08 Cerier Jeffrey C. Tissue fixation devices and methods of fixing tissue
US20040143342A1 (en) * 2003-01-16 2004-07-22 Stack Richard S. Satiation pouches and methods of use
US20040158331A1 (en) * 2002-04-08 2004-08-12 Stack Richard S. Method and apparatus for modifying the exit orifice of a satiation pouch
US20040193190A1 (en) * 2002-11-29 2004-09-30 Liddicoat John R. Apparatus and method for manipulating tissue
US20040193194A1 (en) * 1999-06-22 2004-09-30 Ndo Surgical, Inc., A Massachusetts Corporation Tissue reconfiguration
US20040210243A1 (en) * 2003-04-16 2004-10-21 Jamy Gannoe Method and devices for modifying the function of a body organ
US20040215214A1 (en) * 2000-12-13 2004-10-28 Samuel Crews Methods, devices and systems for forming magnetic anastomoses
US20040225357A1 (en) * 2002-01-23 2004-11-11 Ophtec B.V. Fixation of an intraocular implant to the iris
US20040241768A1 (en) * 2000-05-08 2004-12-02 Whitten David G. Fluorescent polymer-QTL approach to biosensing
US20040249362A1 (en) * 2003-03-28 2004-12-09 Gi Dynamics, Inc. Enzyme sleeve
US20050021059A1 (en) * 2000-04-29 2005-01-27 Cole David H. Magnetic components for use in forming anastomoses, creating ports in vessels and closing openings in tissue
US20050033332A1 (en) * 2003-07-28 2005-02-10 Burnett Daniel R. Pyloric valve corking device and method
US20050033331A1 (en) * 2003-07-28 2005-02-10 Polymorfix, Inc., C/O Medventure Associates Pyloric valve obstructing devices and methods
US20050049718A1 (en) * 2002-11-01 2005-03-03 Valentx, Inc. Gastrointestinal sleeve device and methods for treatment of morbid obesity
US20050055039A1 (en) * 2003-07-28 2005-03-10 Polymorfix, Inc. Devices and methods for pyloric anchoring
WO2005020802A2 (en) * 2003-09-02 2005-03-10 Creighton University Suturing devices and methods
US20050070926A1 (en) * 2003-09-30 2005-03-31 Ortiz Mark S. Applier for fastener for single lumen access anastomosis
US20050080438A1 (en) * 2003-10-14 2005-04-14 Gary Weller System for tissue approximation and fixation
US20050080439A1 (en) * 2000-04-29 2005-04-14 Carson Dean F. Devices and methods for forming magnetic anastomoses and ports in vessels
US20050085923A1 (en) * 2002-12-02 2005-04-21 Gi Dynamics, Inc. Anti-obesity devices
US6896682B1 (en) * 2000-11-14 2005-05-24 Biomedical Engineering Solutions, Inc. Method and system for internal ligation of tubular structures
US20050119674A1 (en) * 2003-10-23 2005-06-02 Peter Gingras Gastric constriction device
US20050125075A1 (en) * 2003-12-09 2005-06-09 Gi Dynamics, Inc. Intestinal sleeve
US20050177181A1 (en) * 2002-11-01 2005-08-11 Jonathan Kagan Devices and methods for treating morbid obesity
US20050177176A1 (en) * 2004-02-05 2005-08-11 Craig Gerbi Single-fold system for tissue approximation and fixation
US20050192615A1 (en) * 2000-11-03 2005-09-01 Torre Roger D.L. Method and device for use in minimally invasive placement of intragastric devices
US20050192603A1 (en) * 2000-12-13 2005-09-01 Medtronic Avecor Cardiovascular, Inc. A Minnesota Corporation Extravascular anastomotic components and methods for forming magnetic anastomoses
US20050203548A1 (en) * 2004-03-09 2005-09-15 Gary Weller Devices and methods for placement of partitions within a hollow body organ
US20050203547A1 (en) * 2004-03-09 2005-09-15 Gary Weller Devices and methods for placement of partitions within a hollow body organ
US20050216042A1 (en) * 2004-03-23 2005-09-29 Michael Gertner Percutaneous gastroplasty
US20050216038A1 (en) * 2001-06-14 2005-09-29 Suturtek Incorporated Apparatus for surgical suturing with thread management
US20050228415A1 (en) * 2004-03-23 2005-10-13 Michael Gertner Methods and devices for percutaneous, non-laparoscopic treatment of obesity
US20050240279A1 (en) * 2002-11-01 2005-10-27 Jonathan Kagan Gastrointestinal sleeve device and methods for treatment of morbid obesity
US20050250980A1 (en) * 2004-05-07 2005-11-10 Usgi Medical Corp. Methods for performing gastroplasty
US20050247320A1 (en) * 2003-10-10 2005-11-10 Stack Richard S Devices and methods for retaining a gastro-esophageal implant
US20050251158A1 (en) * 2004-05-07 2005-11-10 Usgi Medical Inc. Methods and apparatus for performing endoluminal gastroplasty
US20050267533A1 (en) * 2004-03-23 2005-12-01 Michael Gertner Methods and devices for the surgical creation of satiety and biofeedback pathways
US20050273060A1 (en) * 2004-06-03 2005-12-08 Mayo Foundation For Medical Education And Research Obesity treatment and device
US20050274280A1 (en) * 2002-07-27 2005-12-15 Avecia Limited Metal chelate compounds and inks
US20050277945A1 (en) * 2004-06-14 2005-12-15 Usgi Medical Inc. Apparatus and methods for performing transluminal gastrointestinal procedures
US20050288694A1 (en) * 2004-06-23 2005-12-29 Stepehen Solomon Adjustable percutaneous stomach lumen restriction device
US20050285604A1 (en) * 2004-06-29 2005-12-29 Ryoichi Shinohara Partial discharge detecting sensor and gas insulated electric apparatus provided with a partial discharge detecting sensor
US20060015125A1 (en) * 2004-05-07 2006-01-19 Paul Swain Devices and methods for gastric surgery
US20060020277A1 (en) * 2004-07-20 2006-01-26 Gostout Christopher J Gastric reshaping devices and methods
US20060020278A1 (en) * 2003-07-28 2006-01-26 Polymorfix, Inc. Gastric retaining devices and methods
US20060020247A1 (en) * 2002-11-01 2006-01-26 Jonathan Kagan Devices and methods for attaching an endolumenal gastrointestinal implant
US20060036267A1 (en) * 2004-08-11 2006-02-16 Usgi Medical Inc. Methods and apparatus for performing malabsorptive bypass procedures within a patient's gastro-intestinal lumen
US20060047289A1 (en) * 2004-08-27 2006-03-02 Roberto Fogel Endoscopic tissue apposition device and method of use
US20060069396A1 (en) * 2004-09-20 2006-03-30 Suturtek Incorporated Apparatus and method for minimally invasive suturing
US20060089627A1 (en) * 2004-10-26 2006-04-27 Polymorfix, Inc. Medical device delivery catheter
US20060142790A1 (en) * 2004-03-23 2006-06-29 Michael Gertner Methods and devices to facilitate connections between body lumens
US20060155375A1 (en) * 2004-09-27 2006-07-13 Jonathan Kagan Devices and methods for attachment of a gastrointestinal sleeve
US20060161265A1 (en) * 2002-12-02 2006-07-20 Levine Andy H Bariatric sleeve
US20060157067A1 (en) * 2005-01-14 2006-07-20 Usgi Medical Inc. Attenuation of environmental parameters on a gastric lumen
US20060195139A1 (en) * 2004-03-23 2006-08-31 Michael Gertner Extragastric devices and methods for gastroplasty
US20060217757A1 (en) * 2005-03-28 2006-09-28 Horndeski Gary M Device and method of weight control via indirect abdominal cavity volume reduction
US20060217748A1 (en) * 2003-09-30 2006-09-28 Ethicon Endo-Surgery, Inc. Method for Hybrid Gastro-Jejunostomy
US20060253126A1 (en) * 2005-05-04 2006-11-09 Bernard Medical, Llc Endoluminal suturing device and method
US20060253142A1 (en) * 2005-05-04 2006-11-09 Bernard Medical, Llc Endoluminal gastric ring and method
US20060253153A1 (en) * 2005-04-22 2006-11-09 Helmut Schreiber Surgical marker/connector
US20060264982A1 (en) * 2005-05-20 2006-11-23 Viola Frank J Gastric restrictor assembly and method of use
US20060264981A1 (en) * 2005-05-20 2006-11-23 Viola Frank J Gastric restrictor assembly and method of use
US20060276810A1 (en) * 2005-05-09 2006-12-07 Brian Kelleher Methods and apparatus for excising tissue and creating wall-to-wall adhesions from within an organ
US20060282093A1 (en) * 2005-06-13 2006-12-14 Shelton Frederick E Iv Surgical suturing apparatus with anti-backup system
US20060282091A1 (en) * 2005-06-13 2006-12-14 Shelton Frederick E Iv Adjustable vacuum chamber for a surgical suturing apparatus
US20060282098A1 (en) * 2005-06-13 2006-12-14 Shelton Frederick E Iv Surgical suturing apparatus with detachable handle
US20060282107A1 (en) * 2005-05-09 2006-12-14 Kiyoshi Hashiba Intragastric device for treating obesity
US20060282089A1 (en) * 2005-06-13 2006-12-14 Ethicon Endo-Surgery, Inc. Endoscopic suturing device
US20060281970A1 (en) * 2005-06-13 2006-12-14 Stokes Michael J Attachment apparatus for coupling with an endoscope
US20060282099A1 (en) * 2005-06-13 2006-12-14 Stokes Michael J Method for suture lacing
US20060282094A1 (en) * 2005-06-13 2006-12-14 Stokes Michael J Surgical suturing apparatus
US20070010794A1 (en) * 2002-11-01 2007-01-11 Mitchell Dann Devices and methods for endolumenal gastrointestinal bypass
US20070010834A1 (en) * 2000-04-29 2007-01-11 Sharkawy A A Components, systems and methods for forming anastomoses using magnetism or other coupling means
US20070021756A1 (en) * 2002-05-01 2007-01-25 Scimed Life Systems, Inc. Tissue fastening devices and related insertion tools and methods
US20070032800A1 (en) * 2005-08-05 2007-02-08 Ortiz Mark S Apparatus for single pass gastric restriction
US20070032822A1 (en) * 2005-08-05 2007-02-08 Ortiz Mark S Fasteners for use with gastic restriction
US20070032702A1 (en) * 2005-08-05 2007-02-08 Ortiz Mark S Method and apparatus for endoscopically performing gastric reduction surgery
US20070032797A1 (en) * 2005-08-05 2007-02-08 Ortiz Mark S Single pass gastric restriction with a corkscrew style wall anchor
US20070032807A1 (en) * 2005-08-05 2007-02-08 Ortiz Mark S Method and clamp for gastric reduction surgery
US20070043380A1 (en) * 2005-08-05 2007-02-22 Ortiz Mark S Gastric instrument sleeve to prevent cross contamination of stomach content and provide fixation and repeatable path
US20070043384A1 (en) * 2005-08-18 2007-02-22 Ortiz Mark S Method and apparatus for endoscopically performing gastric reduction surgery in a single pass
US20070055292A1 (en) * 2005-09-02 2007-03-08 Ortiz Mark S Method and apparatus for endoscopically performing gastric reduction surgery in a single step
US20070060940A1 (en) * 2003-08-13 2007-03-15 Augusto Brazzini Compressive device for percutaneous treatment of obesity
US20070078296A1 (en) * 2005-10-03 2007-04-05 Sabri Mahmoud T Stomach belt for weight loss
US20070078302A1 (en) * 2005-08-05 2007-04-05 Ortiz Mark S Method and apparatus for sealing a gastric opening
US7211094B2 (en) * 2002-11-05 2007-05-01 Satiety, Inc. Magnetic anchoring devices
US20070106302A1 (en) * 2005-11-04 2007-05-10 Ethicon Endo-Surgery, Inc Lumen traversing device
US20070106313A1 (en) * 2002-09-12 2007-05-10 Steve Golden Anastomosis apparatus and methods
US7220237B2 (en) * 2002-10-23 2007-05-22 Satiety, Inc. Method and device for use in endoscopic organ procedures
US20070114261A1 (en) * 2005-11-23 2007-05-24 Ethicon Endo-Surgery, Inc. Surgical stapler with a bendable end effector
US20070123917A1 (en) * 2005-11-29 2007-05-31 Ortiz Mark S Anastomotic device promoting tissue necrosis
US20070129735A1 (en) * 2005-07-13 2007-06-07 Filipi Charles J Systems and techniques for minimally invasive gastrointestinal procedures
US20070142884A1 (en) * 2005-12-16 2007-06-21 Acoustx Corporation Methods and apparatuses for treating an esophageal disorder such as gastroesophageal reflux disease
US20070142699A1 (en) * 2005-12-16 2007-06-21 Acoustx Corporation Methods and implantable apparatuses for treating an esophageal disorder such as gastroesophageal reflux disease
WO2007078988A2 (en) 2005-12-29 2007-07-12 Satiety, Inc. Devices and methods for placement of partitions within a hollow body organ
US20070167960A1 (en) * 2004-03-09 2007-07-19 Roth Alex T Devices and methods for placement of partitions within a hollow body organ
US20070178160A1 (en) * 2003-07-28 2007-08-02 Baronova, Inc. Gastro-intestinal device and method for treating addiction
US20070185507A1 (en) * 2005-04-22 2007-08-09 Helmut Schreiber Surgical marker/connector and method of installation
US20070191871A1 (en) * 2006-02-10 2007-08-16 Endogastric Solutions, Inc. Transesophageal gastric reduction method and device for reducing the size of a previously formed gastric reduction pouch
US20070198034A1 (en) * 2006-02-17 2007-08-23 Ethicon Endo-Surgery, Inc. Lumen reduction methods and devices
US20070198032A1 (en) * 2006-02-22 2007-08-23 Ethicon Endo-Surgery, Inc. Methods and devices for fastener removal
US20070213745A1 (en) * 2006-03-09 2007-09-13 Olympus Medical Systems Corp. Ligating apparatus
US20070219571A1 (en) * 2005-10-03 2007-09-20 Balbierz Daniel J Endoscopic plication devices and methods
WO2007105220A2 (en) * 2006-03-15 2007-09-20 Noam Calderon Amelioration of urinary incontinence in females
US20070225556A1 (en) * 2006-03-23 2007-09-27 Ethicon Endo-Surgery, Inc. Disposable endoscope devices
US20070233169A1 (en) * 2005-03-28 2007-10-04 Horndeski Gary M Device and Method of Weight Control Via Indirect Abdominal Cavity Volume Reduction
US20070233188A1 (en) * 2006-03-31 2007-10-04 Hunt John V Adhesives for use with suture system minimize tissue erosion
US20070233170A1 (en) * 2004-03-23 2007-10-04 Michael Gertner Extragastric Balloon
US20070239195A1 (en) * 2004-05-18 2007-10-11 Nocca David J Adjustable Prosthetic Band
US20070239179A1 (en) * 2006-03-31 2007-10-11 Ethicon Endo-Surgery, Inc. Compliant Gastroplasty: Devices And Methods
US20070239177A1 (en) * 2006-03-31 2007-10-11 Stokes Michael J Method for instrument insertion through a body orifice
US20070239284A1 (en) * 2005-12-22 2007-10-11 Skerven Gregory J Coiled intragastric member for treating obesity
US20070239175A1 (en) * 2006-03-31 2007-10-11 Stokes Michael J Method for securing a suture
US20070246507A1 (en) * 2000-11-20 2007-10-25 Medigus Ltd. Stapler for endoscopes
US20070250132A1 (en) * 2003-07-28 2007-10-25 Baronova, Inc. Devices and methods for gastrointestinal stimulation
US20070260276A1 (en) * 2003-10-14 2007-11-08 Esophyx, Inc. Transesophageal gastric reduction device, system and method
US20070276409A1 (en) * 2006-05-25 2007-11-29 Ethicon Endo-Surgery, Inc. Endoscopic gastric restriction methods and devices
US20070276411A1 (en) * 2006-05-25 2007-11-29 Ethicon Endo-Surgery, Inc. Absorbable Gastric Restriction Devices and Methods
US20070276428A1 (en) * 2005-12-22 2007-11-29 Haller Frederick B Intragastric bag for treating obesity
US20070293716A1 (en) * 2004-10-15 2007-12-20 Bfkw, Llc Bariatric device and method
US7326207B2 (en) 1999-05-18 2008-02-05 Curon Medical, Inc. Surgical weight control device
US20080058887A1 (en) * 2006-04-25 2008-03-06 Bobby Griffin Methods and devices for gastrointestinal stimulation
US20080058840A1 (en) * 2006-09-01 2008-03-06 Albrecht Thomas E Implantable coil for insertion into a hollow body organ
US20080065122A1 (en) * 2003-10-10 2008-03-13 Stack Richard S Restrictive and/or obstructive implant system for inducing weight loss
US20080089933A1 (en) * 2006-10-16 2008-04-17 Amir Alon Device and method for reducing calorie intake
US20080097487A1 (en) * 2006-10-20 2008-04-24 Scott Pool Method and apparatus for adjusting a gastrointestinal restriction device
US20080097510A1 (en) * 2006-09-01 2008-04-24 Albrecht Thomas E Method for inducing weight loss with a patient
US20080097496A1 (en) * 2006-10-20 2008-04-24 Arvin Chang System and method for securing an implantable interface to a mammal
US20080097483A1 (en) * 2006-05-02 2008-04-24 Ethicon Endo-Surgery, Inc. Suture management
US20080125797A1 (en) * 2006-11-27 2008-05-29 Brian Kelleher Methods and Devices for Organ Partitioning
US20080147112A1 (en) * 2006-10-20 2008-06-19 John Wesley Sheets Stomach invagination method and apparatus
US20080147095A1 (en) * 2000-05-19 2008-06-19 C. R. Bard, Inc Tissue capturing and suturing device and method
US20080154289A1 (en) * 2004-12-21 2008-06-26 Davol Inc. Anastomotic outlet revision
US20080161717A1 (en) * 2005-05-10 2008-07-03 Michael Eric Gertner Obesity Treatment Systems
WO2008085994A2 (en) * 2007-01-08 2008-07-17 Endogastric Solutions Connected fasteners, delivery device and method
US20080195226A1 (en) * 2006-09-02 2008-08-14 Williams Michael S Intestinal sleeves and associated deployment systems and methods
US20080208356A1 (en) * 2001-08-27 2008-08-28 Stack Richard S Satiation devices and methods
US20080215069A1 (en) * 2000-03-03 2008-09-04 C.R. Bard, Inc. Endoscopic tissue apposition device with multiple suction ports
US20080242933A1 (en) * 2006-12-28 2008-10-02 Olympus Medical Systems Corp. Endoscopic treatment tool and suturing method using the same
US20080249540A1 (en) * 2007-04-04 2008-10-09 Stokes Michael J Method for plicating and fastening gastric tissue
US20080249542A1 (en) * 2007-04-04 2008-10-09 Stokes Michael J Device for plicating and fastening gastric tissue
US20080249561A1 (en) * 2007-04-04 2008-10-09 Stokes Michael J Method for plicating and fastening gastric tissue
US20080249539A1 (en) * 2007-04-04 2008-10-09 Stokes Michael J Device for plicating and fastening gastric tissue
US20080249560A1 (en) * 2007-04-04 2008-10-09 Stokes Michael J Method for plicating and fastening gastric tissue
US20080249566A1 (en) * 2007-03-13 2008-10-09 Harris Peter S Methods and devices for reducing gastric volume
US20080249541A1 (en) * 2007-04-04 2008-10-09 Stokes Michael J Device for plicating and fastening gastric tissue
US20080255602A1 (en) * 2006-04-19 2008-10-16 Joshua Makower Devices and methods for treatment of obesity
US20080255592A1 (en) * 2006-10-26 2008-10-16 Hourglass Technologies, Inc. Methods and devices for treating obesity and gerd by intussuscepting a portion of stomach tissue
US20080262515A1 (en) * 2006-12-28 2008-10-23 Joshua Makower Devices and methods for treatment of obesity
US20080275473A1 (en) * 2005-07-13 2008-11-06 Creighton University Systems and techniques for minimally invasive gastrointestinal procedures
US20080281257A1 (en) * 2007-05-10 2008-11-13 Waller David F Intragastric bag apparatus and method of delivery for treating obesity
US20080319455A1 (en) * 2007-03-13 2008-12-25 Harris Peter S Methods and devices for reducing gastric volume
US20080319470A1 (en) * 2007-06-20 2008-12-25 Viola Frank J Gastric restrictor assembly and method of use
US20090012553A1 (en) * 2007-06-08 2009-01-08 Valentx, Inc. Methods and devices for intragastric support of functional or prosthetic gastrointestinal devices
US20090012356A1 (en) * 2007-06-11 2009-01-08 Valen Tx, Inc. Endoscopic delivery devices and methods
US20090012544A1 (en) * 2007-06-08 2009-01-08 Valen Tx, Inc. Gastrointestinal bypass sleeve as an adjunct to bariatric surgery
US20090024143A1 (en) * 2007-07-18 2009-01-22 Crews Samuel T Endoscopic implant system and method
US20090024145A1 (en) * 2006-01-27 2009-01-22 Meade John C Apparatus and method for sternotomy closure
US20090030284A1 (en) * 2007-07-18 2009-01-29 David Cole Overtube introducer for use in endoscopic bariatric surgery
US20090036910A1 (en) * 2006-04-19 2009-02-05 Vibrynt, Inc. Devices and Methods for Treatment of Obesity
US20090099588A1 (en) * 2007-10-11 2009-04-16 Joshua Makower Devices and methods for treatment of obesity
US20090112232A1 (en) * 2007-10-31 2009-04-30 Lawrence Crainich Method for Deploying A Device For Gastric Volume Reduction
US20090118762A1 (en) * 2007-10-31 2009-05-07 Lawrence Crainch Disposable cartridge for use in a gastric volume reduction procedure
US20090149879A1 (en) * 2007-12-10 2009-06-11 Dillon Travis E Dynamic volume displacement weight loss device
US20090164028A1 (en) * 2007-12-21 2009-06-25 Wilson-Cook Medical Inc. Method of delivering an intragastric device for treating obesity
US20090171382A1 (en) * 2007-12-27 2009-07-02 Wilson-Cook Medical Inc. Delivery system and method of delivery for treating obesity
US20090182358A1 (en) * 2007-09-07 2009-07-16 Baronova.Inc. Device for intermittently obstructing a gastric opening and method of use
US20090222032A1 (en) * 2005-03-28 2009-09-03 Horndeski Gary M Device and method of weight control via indirect abdominal cavity volume reduction
US20090236394A1 (en) * 2008-03-18 2009-09-24 David Cole Endoscopic stapling devices and methods
US20090259240A1 (en) * 2008-04-09 2009-10-15 Stryker Development Llc Pyloric valve
US20090259239A1 (en) * 2008-04-09 2009-10-15 Stryker Development Llc Pyloric valve devices and methods
US20090255544A1 (en) * 2008-03-21 2009-10-15 Usgi Medical, Inc. Devices and methods for the endolumenal treatment of obesity
US20090275960A1 (en) * 2008-04-08 2009-11-05 John Mark Provenza Apparatus and method for gastric reduction
US20090275957A1 (en) * 2008-05-01 2009-11-05 Harris Jason L Clip and delivery assembly used in forming a tissue fold
US20090275980A1 (en) * 2008-05-01 2009-11-05 Zeiner Mark S Method and apparatus for the formation of tissue folds
US20090275961A1 (en) * 2008-05-01 2009-11-05 Harris Jason L Gastric volume reduction using anterior to posterior wall junctions
US20090272388A1 (en) * 2006-04-19 2009-11-05 Shuji Uemura Minimally-invasive methods for implanting obesity treatment devices
US20090275937A1 (en) * 2008-05-01 2009-11-05 Stokes Michael J Method and apparatus for marking a lumenal wall
US20090276055A1 (en) * 2008-05-01 2009-11-05 Ethicon Endo-Surgery, Inc. Method for gastric volume reduction surgery
US20090275975A1 (en) * 2008-05-01 2009-11-05 Albrecht Thomas E Gastric coil manipulator
US20090275964A1 (en) * 2008-05-01 2009-11-05 Zeiner Mark S Method of rolling stomach tissue so as to maximize the contact surface area of a fold
US20090275942A1 (en) * 2008-05-01 2009-11-05 Ortiz Mark S Balloon tissue damage device
US20090275977A1 (en) * 2008-05-01 2009-11-05 Zeiner Mark S Tissue conveyor for use in gastric reduction surgery and associated method for use
US7615004B2 (en) 2006-03-30 2009-11-10 Ethicon Endo-Surgery, Inc. Endoscopic ancillary attachment devices
US20090281377A1 (en) * 2006-04-19 2009-11-12 Newell Matthew B Devices, tools and methods for performing minimally invasive abdominal surgical procedures
US20090281568A1 (en) * 2006-06-14 2009-11-12 Juan Carlos Cendan Devices and Methods for Adjustable, Knotless Tissue Approximation
US20090281498A1 (en) * 2006-04-19 2009-11-12 Acosta Pablo G Devices, system and methods for minimally invasive abdominal surgical procedures
US20090287227A1 (en) * 2006-04-19 2009-11-19 Newell Matthew B Minimally invasive ,methods for implanting obesity treatment devices
US20090318936A1 (en) * 2007-03-13 2009-12-24 Longevity Surgical, Inc. Methods, devices and systems for approximation and fastening of soft tissue
US20090326675A1 (en) * 2008-06-27 2009-12-31 Albrecht Thomas E Implantable device for the treatment of obesity
US20100030017A1 (en) * 2007-02-14 2010-02-04 Bkfw,Llc Bariatric device and method
US20100036395A1 (en) * 2004-10-18 2010-02-11 Temple University Of The Commonwealth System Of Higher Education Method and apparatus of endoscopic suturing
US7666180B2 (en) 2005-05-20 2010-02-23 Tyco Healthcare Group Lp Gastric restrictor assembly and method of use
US7678068B2 (en) 2002-12-02 2010-03-16 Gi Dynamics, Inc. Atraumatic delivery devices
US7695446B2 (en) 2002-12-02 2010-04-13 Gi Dynamics, Inc. Methods of treatment using a bariatric sleeve
US7704264B2 (en) 1999-06-25 2010-04-27 Usgi Medical, Inc. Apparatus and methods for forming and securing gastrointestinal tissue folds
US7703459B2 (en) 2004-03-09 2010-04-27 Usgi Medical, Inc. Apparatus and methods for mapping out endoluminal gastrointestinal surgery
US7708684B2 (en) 2004-02-27 2010-05-04 Satiety, Inc. Methods and devices for reducing hollow organ volume
US20100145324A1 (en) * 2008-12-05 2010-06-10 Raj Nihalani Gastric restriction devices with fillable chambers and ablation means for treating obesity
US20100145370A1 (en) * 2008-12-05 2010-06-10 Anteromed, Inc. Method and apparatus for gastric restriction of the stomach to treat obesity
US7736373B2 (en) 1999-06-22 2010-06-15 Ndo Surical, Inc. Methods and devices for tissue reconfiguration
US7736374B2 (en) 2004-05-07 2010-06-15 Usgi Medical, Inc. Tissue manipulation and securement system
US20100152751A1 (en) * 2004-09-20 2010-06-17 Endoevolution, Llc Apparatus and method for minimally invasive suturing
US20100160995A1 (en) * 2008-12-18 2010-06-24 Jerome Dargent Method for treating obesity
US20100160934A1 (en) * 2002-09-09 2010-06-24 Brian Kelleher Device and Method for Endoluminal Therapy
US7753870B2 (en) 2004-03-26 2010-07-13 Satiety, Inc. Systems and methods for treating obesity
US20100198237A1 (en) * 2007-02-14 2010-08-05 Sentinel Group, Llc Mucosal capture fixation of medical device
US7776057B2 (en) 1999-06-22 2010-08-17 Ethicon Endo-Surgery, Inc. Methods and devices for tissue reconfiguration
US20100234682A1 (en) * 2004-03-23 2010-09-16 Michael Gertner Closed loop gastric restriction devices and methods
US20100249822A1 (en) * 2009-03-31 2010-09-30 Raj Nihalani Method and apparatus for treating obesity and controlling weight gain using adjustable intragastric devices
US20100249825A1 (en) * 2009-03-31 2010-09-30 Raj Nihalani Method and apparatus for treating obesity and controlling weight gain using self-expanding intragastric devices
US20100256775A1 (en) * 2009-04-03 2010-10-07 Metamodix, Inc. Modular gastrointestinal prostheses
US7815591B2 (en) 2004-09-17 2010-10-19 Gi Dynamics, Inc. Atraumatic gastrointestinal anchor
US20100286745A1 (en) * 2003-10-22 2010-11-11 Intrapace, Inc. Radially Expandable Gastrointestinal Stimulation Device
US7837643B2 (en) 2004-07-09 2010-11-23 Gi Dynamics, Inc. Methods and devices for placing a gastrointestinal sleeve
US20100318015A1 (en) * 2007-05-29 2010-12-16 Kassab Ghassan S Devices, systems, and methods for achieving magnetic gastric bypass
US20100324572A1 (en) * 2007-02-06 2010-12-23 The Ohio State University Research Foundation Endolumenal Restriction Method and Apparatus
US20110009690A1 (en) * 2009-07-10 2011-01-13 Metamodix, Inc. External Anchoring Configurations for Modular Gastrointestinal Prostheses
US7892292B2 (en) 2001-08-27 2011-02-22 Synecor, Llc Positioning tools and methods for implanting medical devices
US7914543B2 (en) 2003-10-14 2011-03-29 Satiety, Inc. Single fold device for tissue fixation
US7918845B2 (en) 2003-01-15 2011-04-05 Usgi Medical, Inc. Endoluminal tool deployment system
US7922063B2 (en) 2007-10-31 2011-04-12 Tyco Healthcare Group, Lp Powered surgical instrument
US20110098725A1 (en) * 2009-09-03 2011-04-28 Usgi Medical, Inc. Devices and methods for endolumenal weight loss treatments
US7934631B2 (en) 2008-11-10 2011-05-03 Barosense, Inc. Multi-fire stapling systems and methods for delivering arrays of staples
US7942898B2 (en) 2002-12-11 2011-05-17 Usgi Medical, Inc. Delivery systems and methods for gastric reduction
US7942884B2 (en) 2002-12-11 2011-05-17 Usgi Medical, Inc. Methods for reduction of a gastric lumen
US20110118650A1 (en) * 2009-11-18 2011-05-19 Anteromed, Inc. Method and apparatus for treating obesity and controlling weight gain and absorption of glucose in mammals
US7947055B2 (en) 2002-08-30 2011-05-24 Ethicon Endo-Surgery, Inc. Methods and devices for maintaining a space occupying device in a relatively fixed location within a stomach
US7967818B2 (en) 2005-06-10 2011-06-28 Cook Medical Technologies Llc Cautery catheter
US7976554B2 (en) 2006-04-19 2011-07-12 Vibrynt, Inc. Devices, tools and methods for performing minimally invasive abdominal surgical procedures
US7976555B2 (en) 2008-07-17 2011-07-12 Endoevolution, Llc Apparatus and method for minimally invasive suturing
US7976488B2 (en) 2005-06-08 2011-07-12 Gi Dynamics, Inc. Gastrointestinal anchor compliance
US7993354B1 (en) 2010-10-01 2011-08-09 Endoevolution, Llc Devices and methods for minimally invasive suturing
US7997468B2 (en) 2008-05-05 2011-08-16 Tyco Healthcare Group Lp Surgical instrument with clamp
US8057386B2 (en) 2002-09-06 2011-11-15 C.R. Bard, Inc. Integrated endoscope and accessory treatment device
US8057420B2 (en) 2003-12-09 2011-11-15 Gi Dynamics, Inc. Gastrointestinal implant with drawstring
US20110288576A1 (en) * 2010-05-21 2011-11-24 Jason Lane Hoffman Hoffy Bougie Gastric Tube
WO2011146853A2 (en) 2010-05-21 2011-11-24 Barosense, Inc. Tissue-acquisition and fastening devices and methods
US8066719B2 (en) 2002-12-11 2011-11-29 Ewers Richard C Apparatus and methods for forming gastrointestinal tissue approximations
US8075573B2 (en) 2003-05-16 2011-12-13 C.R. Bard, Inc. Single intubation, multi-stitch endoscopic suturing system
CN101327140B (en) * 2007-06-22 2012-01-04 伊西康内外科公司 Surgical stapling instrument with a return mechanism
US8092482B2 (en) 2002-08-30 2012-01-10 Ethicon Endo-Surgery, Inc. Stented anchoring of gastric space-occupying devices
US8092378B2 (en) 2004-11-17 2012-01-10 Ethicon Endo-Surgery, Inc. Remote tissue retraction device
US20120109159A1 (en) * 2010-11-01 2012-05-03 Gary Jordan Tissue closure
US8187297B2 (en) 2006-04-19 2012-05-29 Vibsynt, Inc. Devices and methods for treatment of obesity
US8216253B2 (en) 2004-05-07 2012-07-10 Usgi Medical, Inc. Apparatus for manipulating and securing tissue
US8216260B2 (en) 2002-12-11 2012-07-10 Usgi Medical, Inc. Apparatus and methods for forming and securing gastrointestinal tissue folds
US8216252B2 (en) 2004-05-07 2012-07-10 Usgi Medical, Inc. Tissue manipulation and securement system
US8236009B2 (en) 2004-05-07 2012-08-07 Usgi Medical, Inc. Needle assembly for tissue manipulation
US8241202B2 (en) 2004-04-26 2012-08-14 Barosense, Inc. Restrictive and/or obstructive implant for inducing weight loss
US8257365B2 (en) 2004-02-13 2012-09-04 Ethicon Endo-Surgery, Inc. Methods and devices for reducing hollow organ volume
US8257394B2 (en) 2004-05-07 2012-09-04 Usgi Medical, Inc. Apparatus and methods for positioning and securing anchors
US8287554B2 (en) 1999-06-22 2012-10-16 Ethicon Endo-Surgery, Inc. Method and devices for tissue reconfiguration
US8298291B2 (en) 2005-05-26 2012-10-30 Usgi Medical, Inc. Methods and apparatus for securing and deploying tissue anchors
US8317808B2 (en) 2008-02-18 2012-11-27 Covidien Lp Device and method for rolling and inserting a prosthetic patch into a body cavity
US8337388B2 (en) 2005-10-24 2012-12-25 Gil Vardi System and method to restrict stomach size
US8382775B1 (en) 2012-01-08 2013-02-26 Vibrynt, Inc. Methods, instruments and devices for extragastric reduction of stomach volume
US8398668B2 (en) 2006-04-19 2013-03-19 Vibrynt, Inc. Devices and methods for treatment of obesity
US8444657B2 (en) 2004-05-07 2013-05-21 Usgi Medical, Inc. Apparatus and methods for rapid deployment of tissue anchors
US8443808B2 (en) 2007-03-19 2013-05-21 Hologic, Inc. Methods and apparatus for occlusion of body lumens
WO2013106752A1 (en) * 2012-01-13 2013-07-18 Barosense, Inc. Tissue-acquisition device and method
US8518062B2 (en) 2000-04-29 2013-08-27 Medtronic, Inc. Devices and methods for forming magnetic anastomoses between vessels
US20130304091A1 (en) * 2012-05-11 2013-11-14 Ethicon, Inc. Applicator instruments having distal end caps for facilitating the accurate placement of surgical fasteners during open repair procedures
US8641711B2 (en) 2007-05-04 2014-02-04 Covidien Lp Method and apparatus for gastrointestinal tract ablation for treatment of obesity
US8702641B2 (en) 2009-04-03 2014-04-22 Metamodix, Inc. Gastrointestinal prostheses having partial bypass configurations
US8726909B2 (en) 2006-01-27 2014-05-20 Usgi Medical, Inc. Methods and apparatus for revision of obesity procedures
US8753359B2 (en) 2008-02-18 2014-06-17 Covidien Lp Device and method for deploying and attaching an implant to a biological tissue
US8801647B2 (en) 2007-02-22 2014-08-12 Gi Dynamics, Inc. Use of a gastrointestinal sleeve to treat bariatric surgery fistulas and leaks
US8808314B2 (en) 2008-02-18 2014-08-19 Covidien Lp Device and method for deploying and attaching an implant to a biological tissue
US8852216B2 (en) 2007-03-23 2014-10-07 Ethicon Endo-Surgery, Inc. Tissue approximation methods
US8870916B2 (en) 2006-07-07 2014-10-28 USGI Medical, Inc Low profile tissue anchors, tissue anchor systems, and methods for their delivery and use
US8888811B2 (en) 2008-10-20 2014-11-18 Covidien Lp Device and method for attaching an implant to biological tissue
US8906045B2 (en) 2009-08-17 2014-12-09 Covidien Lp Articulating patch deployment device and method of use
US8926634B2 (en) 2004-05-07 2015-01-06 Usgi Medical, Inc. Apparatus and methods for manipulating and securing tissue
US8945167B2 (en) 2007-12-31 2015-02-03 Boston Scientific Scimed, Inc. Gastric space occupier systems and methods of use
US8956318B2 (en) 2012-05-31 2015-02-17 Valentx, Inc. Devices and methods for gastrointestinal bypass
US8961539B2 (en) 2009-05-04 2015-02-24 Boston Scientific Scimed, Inc. Endoscopic implant system and method
US8992547B2 (en) 2012-03-21 2015-03-31 Ethicon Endo-Surgery, Inc. Methods and devices for creating tissue plications
US9005241B2 (en) 2008-02-18 2015-04-14 Covidien Lp Means and method for reversibly connecting a patch to a patch deployment device
US9011365B2 (en) 2013-03-12 2015-04-21 Medibotics Llc Adjustable gastrointestinal bifurcation (AGB) for reduced absorption of unhealthy food
US9034002B2 (en) 2008-02-18 2015-05-19 Covidien Lp Lock bar spring and clip for implant deployment device
US9044235B2 (en) 2008-02-18 2015-06-02 Covidien Lp Magnetic clip for implant deployment device
US9055998B2 (en) 2004-10-15 2015-06-16 Bfkw, Llc Bariatric device and method for recipient with altered anatomy
US9067070B2 (en) 2013-03-12 2015-06-30 Medibotics Llc Dysgeusia-inducing neurostimulation for modifying consumption of a selected nutrient type
US9113879B2 (en) 2011-12-15 2015-08-25 Ethicon Endo-Surgery, Inc. Devices and methods for endoluminal plication
US9113868B2 (en) 2011-12-15 2015-08-25 Ethicon Endo-Surgery, Inc. Devices and methods for endoluminal plication
US9125660B2 (en) 2013-04-14 2015-09-08 Easynotes Ltd. Inflation and deflation of obstruction device
US9173760B2 (en) 2009-04-03 2015-11-03 Metamodix, Inc. Delivery devices and methods for gastrointestinal implants
US9198755B2 (en) 2008-03-25 2015-12-01 Ellipse Technologies, Inc. Adjustable implant system
US9265514B2 (en) 2012-04-17 2016-02-23 Miteas Ltd. Manipulator for grasping tissue
US9278019B2 (en) 2009-04-03 2016-03-08 Metamodix, Inc Anchors and methods for intestinal bypass sleeves
US9301826B2 (en) 2008-02-18 2016-04-05 Covidien Lp Lock bar spring and clip for implant deployment device
WO2016056016A1 (en) 2014-10-08 2016-04-14 Nitinotes Ltd. Endoluminal sleeve gastroplasty
US9314361B2 (en) 2006-09-15 2016-04-19 Boston Scientific Scimed, Inc. System and method for anchoring stomach implant
US9314362B2 (en) 2012-01-08 2016-04-19 Vibrynt, Inc. Methods, instruments and devices for extragastric reduction of stomach volume
US9320715B2 (en) 2011-03-29 2016-04-26 Slendine Sa Devices and methods for weight control and weight loss
US9375338B2 (en) 2011-05-20 2016-06-28 Bfkw, Llc Intraluminal device and method with enhanced anti-migration
US9393002B2 (en) 2008-02-18 2016-07-19 Covidien Lp Clip for implant deployment device
US9393093B2 (en) 2008-02-18 2016-07-19 Covidien Lp Clip for implant deployment device
US9398944B2 (en) 2008-02-18 2016-07-26 Covidien Lp Lock bar spring and clip for implant deployment device
US9451960B2 (en) 2012-05-31 2016-09-27 Valentx, Inc. Devices and methods for gastrointestinal bypass
US9456917B2 (en) 2013-08-28 2016-10-04 Ethicon Endo-Surgery, Inc. Endoscopic transoral duodenal sleeve applier
US9456916B2 (en) 2013-03-12 2016-10-04 Medibotics Llc Device for selectively reducing absorption of unhealthy food
US9526648B2 (en) 2010-06-13 2016-12-27 Synerz Medical, Inc. Intragastric device for treating obesity
US9545326B2 (en) 2012-03-06 2017-01-17 Bfkw, Llc Intraluminal device delivery technique
US9585651B2 (en) 2005-05-26 2017-03-07 Usgi Medical, Inc. Methods and apparatus for securing and deploying tissue anchors
US9622897B1 (en) 2016-03-03 2017-04-18 Metamodix, Inc. Pyloric anchors and methods for intestinal bypass sleeves
US9675489B2 (en) 2012-05-31 2017-06-13 Valentx, Inc. Devices and methods for gastrointestinal bypass
US9675339B2 (en) 2004-09-20 2017-06-13 Endoevolution, Llc Devices and methods for minimally invasive suturing
US20170165092A1 (en) * 2008-01-29 2017-06-15 Forsell Peter Method and instrument for treating obesity
US9757264B2 (en) 2013-03-13 2017-09-12 Valentx, Inc. Devices and methods for gastrointestinal bypass
US9775735B2 (en) 2014-01-31 2017-10-03 Covidien Lp Gastric calibration tube
US9833240B2 (en) 2008-02-18 2017-12-05 Covidien Lp Lock bar spring and clip for implant deployment device
US9918863B2 (en) 2013-11-13 2018-03-20 Covidien Lp Steerable gastric calibration tube
US9999424B2 (en) 2009-08-17 2018-06-19 Covidien Lp Means and method for reversibly connecting an implant to a deployment device
US10016220B2 (en) 2011-11-01 2018-07-10 Nuvasive Specialized Orthopedics, Inc. Adjustable magnetic devices and methods of using same
US10070981B2 (en) 2013-03-15 2018-09-11 Baronova, Inc. Locking gastric obstruction device and method of use
US10123896B2 (en) 2014-03-06 2018-11-13 Mayo Foundation For Medical Education And Research Apparatus and methods of inducing weight loss using blood flow control
US10159699B2 (en) 2013-01-15 2018-12-25 Metamodix, Inc. System and method for affecting intestinal microbial flora
US10219931B2 (en) 2011-11-09 2019-03-05 Easynotes Ltd. Obstruction device
US10238427B2 (en) 2015-02-19 2019-03-26 Nuvasive Specialized Orthopedics, Inc. Systems and methods for vertebral adjustment
US10271885B2 (en) 2014-12-26 2019-04-30 Nuvasive Specialized Orthopedics, Inc. Systems and methods for distraction
US10271940B2 (en) 2014-12-29 2019-04-30 Bfkw, Llc Fixation of intraluminal device
US10292698B2 (en) 2017-07-27 2019-05-21 Endoevolution, Llc Apparatus and method for minimally invasive suturing
US10342690B2 (en) 2002-09-09 2019-07-09 Brian Kelleher Device and method for endoluminal therapy
US10349995B2 (en) 2007-10-30 2019-07-16 Nuvasive Specialized Orthopedics, Inc. Skeletal manipulation method
US10350099B2 (en) 2006-09-01 2019-07-16 Ethicon Endo-Surgery, Inc. Devices and methods for anchoring an endoluminal sleeve in the GI tract
US10405891B2 (en) 2010-08-09 2019-09-10 Nuvasive Specialized Orthopedics, Inc. Maintenance feature in magnetic implant
US10413436B2 (en) 2010-06-13 2019-09-17 W. L. Gore & Associates, Inc. Intragastric device for treating obesity
US10420665B2 (en) 2010-06-13 2019-09-24 W. L. Gore & Associates, Inc. Intragastric device for treating obesity
US10456128B2 (en) 2005-06-13 2019-10-29 Ethicon Llc Method for suture lacing
US10478232B2 (en) 2009-04-29 2019-11-19 Nuvasive Specialized Orthopedics, Inc. Interspinous process device and method
US10517643B2 (en) 2009-02-23 2019-12-31 Nuvasive Specialized Orthopedics, Inc. Non-invasive adjustable distraction system
US10542968B2 (en) 2016-12-23 2020-01-28 Brigham And Women's Hospital, Inc. Systems and methods for suturing tissue
US10617453B2 (en) 2015-10-16 2020-04-14 Nuvasive Specialized Orthopedics, Inc. Adjustable devices for treating arthritis of the knee
US10646262B2 (en) 2011-02-14 2020-05-12 Nuvasive Specialized Orthopedics, Inc. System and method for altering rotational alignment of bone sections
US10660675B2 (en) 2010-06-30 2020-05-26 Nuvasive Specialized Orthopedics, Inc. External adjustment device for distraction device
WO2020144693A1 (en) 2019-01-09 2020-07-16 Nitinotes Ltd. Tissue manipulation with an endoluminal gastroplasty device
US10729470B2 (en) 2008-11-10 2020-08-04 Nuvasive Specialized Orthopedics, Inc. External adjustment device for distraction device
US10743794B2 (en) 2011-10-04 2020-08-18 Nuvasive Specialized Orthopedics, Inc. Devices and methods for non-invasive implant length sensing
US10751094B2 (en) 2013-10-10 2020-08-25 Nuvasive Specialized Orthopedics, Inc. Adjustable spinal implant
US10751209B2 (en) 2016-05-19 2020-08-25 Metamodix, Inc. Pyloric anchor retrieval tools and methods
US10779980B2 (en) 2016-04-27 2020-09-22 Synerz Medical, Inc. Intragastric device for treating obesity
US10799233B2 (en) 2012-05-01 2020-10-13 Brigham And Women's Hospital, Inc. Suturing device for laparoscopic procedures
US10835290B2 (en) 2015-12-10 2020-11-17 Nuvasive Specialized Orthopedics, Inc. External adjustment device for distraction device
US10918425B2 (en) 2016-01-28 2021-02-16 Nuvasive Specialized Orthopedics, Inc. System and methods for bone transport
US11013629B2 (en) 2014-12-29 2021-05-25 Bfkw, Llc Fixation of intraluminal device
US11020213B2 (en) 2014-12-29 2021-06-01 Bfkw, Llc Fixation of intraluminal device
US11135078B2 (en) 2010-06-13 2021-10-05 Synerz Medical, Inc. Intragastric device for treating obesity
US11191579B2 (en) 2012-10-29 2021-12-07 Nuvasive Specialized Orthopedics, Inc. Adjustable devices for treating arthritis of the knee
US11202707B2 (en) 2008-03-25 2021-12-21 Nuvasive Specialized Orthopedics, Inc. Adjustable implant system
US11246694B2 (en) 2014-04-28 2022-02-15 Nuvasive Specialized Orthopedics, Inc. System for informational magnetic feedback in adjustable implants
US11253250B2 (en) 2017-02-26 2022-02-22 Intuitive Surgical Operations, Inc. Apparatus and method for minimally invasive suturing
US11357549B2 (en) 2004-07-02 2022-06-14 Nuvasive Specialized Orthopedics, Inc. Expandable rod system to treat scoliosis and method of using the same
US11696678B2 (en) 2012-05-11 2023-07-11 Ethicon, Inc. Applicator instruments with inverted handles and triggers, curved shafts, and visible orientation indicia
US11737901B2 (en) * 2011-04-04 2023-08-29 FreeHold Surgical, LLC Method for performing a gastrectomy

Families Citing this family (488)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6991643B2 (en) * 2000-12-20 2006-01-31 Usgi Medical Inc. Multi-barbed device for retaining tissue in apposition and methods of use
US20040215235A1 (en) 1999-11-16 2004-10-28 Barrx, Inc. Methods and systems for determining physiologic characteristics for treatment of the esophagus
US20060095032A1 (en) 1999-11-16 2006-05-04 Jerome Jackson Methods and systems for determining physiologic characteristics for treatment of the esophagus
US20020082621A1 (en) 2000-09-22 2002-06-27 Schurr Marc O. Methods and devices for folding and securing tissue
US7727246B2 (en) * 2000-12-06 2010-06-01 Ethicon Endo-Surgery, Inc. Methods for endoluminal treatment
US20060052821A1 (en) * 2001-09-06 2006-03-09 Ovalis, Inc. Systems and methods for treating septal defects
US7695427B2 (en) 2002-04-26 2010-04-13 Torax Medical, Inc. Methods and apparatus for treating body tissue sphincters and the like
US7497822B1 (en) * 2003-04-10 2009-03-03 Torax Medical, Inc. Stomach reduction methods and apparatus
JP2005525862A (en) * 2002-05-17 2005-09-02 オーナックス・メディカル・インコーポレーテッド Surgical suture instrument and method of use thereof
US6773440B2 (en) * 2002-07-02 2004-08-10 Satiety, Inc. Method and device for use in tissue approximation and fixation
JP2005532121A (en) * 2002-07-09 2005-10-27 イーバ コーポレイション Introduction device used in surgery and method of use thereof
US20070032879A1 (en) * 2002-12-02 2007-02-08 Levine Andy H Anti-buckling sleeve
AU2003294347A1 (en) * 2002-12-30 2004-07-29 Fannie Mae System and method for processing data pertaining to financial assets
US20040249367A1 (en) * 2003-01-15 2004-12-09 Usgi Medical Corp. Endoluminal tool deployment system
US20070084897A1 (en) 2003-05-20 2007-04-19 Shelton Frederick E Iv Articulating surgical stapling instrument incorporating a two-piece e-beam firing mechanism
US9060770B2 (en) 2003-05-20 2015-06-23 Ethicon Endo-Surgery, Inc. Robotically-driven surgical instrument with E-beam driver
US20040253274A1 (en) * 2003-06-11 2004-12-16 Allergan, Inc. Use of a clostridial toxin to reduce appetite
US7500944B2 (en) * 2003-06-27 2009-03-10 Ethicon Endo-Surgery, Inc. Implantable band with attachment mechanism
US20050002984A1 (en) * 2003-06-27 2005-01-06 Byrum Randal T. Implantable band with attachment mechanism having dissimilar material properties
US7951067B2 (en) * 2003-06-27 2011-05-31 Ethicon Endo-Surgery, Inc. Implantable band having improved attachment mechanism
US20040267292A1 (en) * 2003-06-27 2004-12-30 Byrum Randal T. Implantable band with transverse attachment mechanism
US20120283756A1 (en) * 2003-08-11 2012-11-08 Usgi Medical, Inc. Treatment of hypertension and heart disease via surgery of the stomach
EP1656070B1 (en) * 2003-08-11 2009-09-23 Wilson-Cook Medical Inc. Surgical implant
US8394114B2 (en) 2003-09-26 2013-03-12 Medtronic, Inc. Surgical connection apparatus and methods
US7169115B2 (en) 2003-09-29 2007-01-30 Ethicon Endo-Surgery, Inc. Endoscopic mucosal resection device with overtube and method of use
US7186252B2 (en) 2003-09-29 2007-03-06 Ethicon Endo-Surgery, Inc. Endoscopic mucosal resection device and method of use
US6994705B2 (en) * 2003-09-29 2006-02-07 Ethicon-Endo Surgery, Inc. Endoscopic mucosal resection device with conductive tissue stop
US7252665B2 (en) * 2003-10-31 2007-08-07 Medtronic, Inc Ablation of stomach lining to reduce stomach acid secretion
US7282050B2 (en) * 2003-10-31 2007-10-16 Medtronic, Inc. Ablation of exterior of stomach to treat obesity
JP4540328B2 (en) * 2003-11-19 2010-09-08 カール事務器株式会社 Multi-function drilling device
US20060212042A1 (en) * 2005-03-17 2006-09-21 Lamport Ronald B Removal and repositioning device
US8915967B2 (en) * 2003-12-19 2014-12-23 Patrick Leahy Anti reflux system
US7041124B2 (en) * 2003-12-23 2006-05-09 Kimberly-Clark Worldwide, Inc. System and method for providing therapy to a portion of a body
US7150745B2 (en) 2004-01-09 2006-12-19 Barrx Medical, Inc. Devices and methods for treatment of luminal tissue
DE102004011764A1 (en) * 2004-03-09 2005-09-29 Novineon Healthcare Technology Partners Gmbh Medical implant
US20050272977A1 (en) * 2004-04-14 2005-12-08 Usgi Medical Inc. Methods and apparatus for performing endoluminal procedures
US8512229B2 (en) * 2004-04-14 2013-08-20 Usgi Medical Inc. Method and apparatus for obtaining endoluminal access
US8277373B2 (en) 2004-04-14 2012-10-02 Usgi Medical, Inc. Methods and apparaus for off-axis visualization
US8562516B2 (en) * 2004-04-14 2013-10-22 Usgi Medical Inc. Methods and apparatus for obtaining endoluminal access
US20050245788A1 (en) * 2004-04-28 2005-11-03 Medtronic, Inc. Esophageal delivery system and method with position indexing
US8057511B2 (en) 2004-05-07 2011-11-15 Usgi Medical, Inc. Apparatus and methods for positioning and securing anchors
US20050267529A1 (en) * 2004-05-13 2005-12-01 Heber Crockett Devices, systems and methods for tissue repair
US7695493B2 (en) 2004-06-09 2010-04-13 Usgi Medical, Inc. System for optimizing anchoring force
US7736379B2 (en) 2004-06-09 2010-06-15 Usgi Medical, Inc. Compressible tissue anchor assemblies
US8206417B2 (en) 2004-06-09 2012-06-26 Usgi Medical Inc. Apparatus and methods for optimizing anchoring force
US7678135B2 (en) 2004-06-09 2010-03-16 Usgi Medical, Inc. Compressible tissue anchor assemblies
US11890012B2 (en) 2004-07-28 2024-02-06 Cilag Gmbh International Staple cartridge comprising cartridge body and attached support
US8215531B2 (en) 2004-07-28 2012-07-10 Ethicon Endo-Surgery, Inc. Surgical stapling instrument having a medical substance dispenser
US8623036B2 (en) * 2004-09-29 2014-01-07 The Regents Of The University Of California Magnamosis
US8623009B2 (en) * 2005-04-05 2014-01-07 The Brigham And Women's Hospital, Inc. Endoscopic gastric bypass defect repair
AU2005330683B2 (en) * 2005-04-15 2012-04-19 Ethicon Endo-Surgery, Inc Single fold device for tissue fixation
WO2006112849A1 (en) * 2005-04-15 2006-10-26 Satiety, Inc. Single fold device for tissue fixation
US7736392B2 (en) * 2005-04-28 2010-06-15 Medtronic, Inc. Bulking of upper esophageal sphincter for treatment of obesity
US8021384B2 (en) * 2005-07-26 2011-09-20 Ram Weiss Extending intrabody capsule
US11246590B2 (en) 2005-08-31 2022-02-15 Cilag Gmbh International Staple cartridge including staple drivers having different unfired heights
US9237891B2 (en) 2005-08-31 2016-01-19 Ethicon Endo-Surgery, Inc. Robotically-controlled surgical stapling devices that produce formed staples having different lengths
US7934630B2 (en) 2005-08-31 2011-05-03 Ethicon Endo-Surgery, Inc. Staple cartridges for forming staples having differing formed staple heights
US11484312B2 (en) 2005-08-31 2022-11-01 Cilag Gmbh International Staple cartridge comprising a staple driver arrangement
US7669746B2 (en) 2005-08-31 2010-03-02 Ethicon Endo-Surgery, Inc. Staple cartridges for forming staples having differing formed staple heights
US10159482B2 (en) 2005-08-31 2018-12-25 Ethicon Llc Fastener cartridge assembly comprising a fixed anvil and different staple heights
EP2001401A4 (en) * 2005-09-09 2009-01-07 Biomedix Sa Medical device and method for controlling obesity
US20080190989A1 (en) * 2005-10-03 2008-08-14 Crews Samuel T Endoscopic plication device and method
US20070106317A1 (en) 2005-11-09 2007-05-10 Shelton Frederick E Iv Hydraulically and electrically actuated articulation joints for surgical instruments
US7959627B2 (en) * 2005-11-23 2011-06-14 Barrx Medical, Inc. Precision ablating device
US8702694B2 (en) 2005-11-23 2014-04-22 Covidien Lp Auto-aligning ablating device and method of use
US7997278B2 (en) 2005-11-23 2011-08-16 Barrx Medical, Inc. Precision ablating method
US20070198039A1 (en) * 2006-01-27 2007-08-23 Wilson-Cook Medical, Inc. Intragastric device for treating obesity
US11793518B2 (en) 2006-01-31 2023-10-24 Cilag Gmbh International Powered surgical instruments with firing system lockout arrangements
US8186555B2 (en) 2006-01-31 2012-05-29 Ethicon Endo-Surgery, Inc. Motor-driven surgical cutting and fastening instrument with mechanical closure system
US7753904B2 (en) 2006-01-31 2010-07-13 Ethicon Endo-Surgery, Inc. Endoscopic surgical instrument with a handle that can articulate with respect to the shaft
US20110290856A1 (en) 2006-01-31 2011-12-01 Ethicon Endo-Surgery, Inc. Robotically-controlled surgical instrument with force-feedback capabilities
US8820603B2 (en) 2006-01-31 2014-09-02 Ethicon Endo-Surgery, Inc. Accessing data stored in a memory of a surgical instrument
US11278279B2 (en) 2006-01-31 2022-03-22 Cilag Gmbh International Surgical instrument assembly
US8708213B2 (en) 2006-01-31 2014-04-29 Ethicon Endo-Surgery, Inc. Surgical instrument having a feedback system
US20110024477A1 (en) 2009-02-06 2011-02-03 Hall Steven G Driven Surgical Stapler Improvements
US7845537B2 (en) 2006-01-31 2010-12-07 Ethicon Endo-Surgery, Inc. Surgical instrument having recording capabilities
US20120292367A1 (en) 2006-01-31 2012-11-22 Ethicon Endo-Surgery, Inc. Robotically-controlled end effector
US11224427B2 (en) 2006-01-31 2022-01-18 Cilag Gmbh International Surgical stapling system including a console and retraction assembly
US7625392B2 (en) * 2006-02-03 2009-12-01 James Coleman Wound closure devices and methods
US20170014132A9 (en) * 2006-02-10 2017-01-19 Steve G. Baker Transesophageal gastric reduction method and device for reducing the size of a previously formed gastric reduction pouch
US7794386B2 (en) 2006-03-15 2010-09-14 Allergan, Inc. Methods for facilitating weight loss
US8992422B2 (en) 2006-03-23 2015-03-31 Ethicon Endo-Surgery, Inc. Robotically-controlled endoscopic accessory channel
US20090281376A1 (en) * 2006-04-19 2009-11-12 Acosta Pablo G Devices, system and methods for minimally invasive abdominal surgical procedures
US20090275972A1 (en) * 2006-04-19 2009-11-05 Shuji Uemura Minimally-invasive methods for implanting obesity treatment devices
US20090281386A1 (en) * 2006-04-19 2009-11-12 Acosta Pablo G Devices, system and methods for minimally invasive abdominal surgical procedures
US7867283B2 (en) * 2006-05-30 2011-01-11 Boston Scientific Scimed, Inc. Anti-obesity diverter structure
ITTO20060413A1 (en) * 2006-06-07 2007-12-08 Arrigo Lessana REPLACEMENT DEVICE OF THE TENDONE ROPES OF AN ATRIOVENTRICULAR VALVE
US8322455B2 (en) 2006-06-27 2012-12-04 Ethicon Endo-Surgery, Inc. Manually driven surgical cutting and fastening instrument
US20090125040A1 (en) * 2006-09-13 2009-05-14 Hambly Pablo R Tissue acquisition devices and methods
US8118774B2 (en) 2006-09-25 2012-02-21 Valentx, Inc. Toposcopic access and delivery devices
US10568652B2 (en) 2006-09-29 2020-02-25 Ethicon Llc Surgical staples having attached drivers of different heights and stapling instruments for deploying the same
EP2076183A4 (en) * 2006-10-04 2009-09-16 Ndo Surgical Inc Devices and methods for endoluminal gastric restriction tissue manipulation, and drug delivery
US20080092910A1 (en) * 2006-10-18 2008-04-24 Allergan, Inc. Apparatus and method for treating obesity using neurotoxins in conjunction with bariatric procedures
US8628553B2 (en) * 2006-11-08 2014-01-14 Ethicon Endo-Surgery, Inc. Expanding adhesive foam structure to reduce stomach volume
US7780685B2 (en) * 2006-11-09 2010-08-24 Ethicon Endo-Surgery, Inc. Adhesive and mechanical fastener
US20080249404A1 (en) 2006-12-28 2008-10-09 Olympus Medical Systems Corp. Gastric therapy system and method for suturing gastric wall
US8652120B2 (en) 2007-01-10 2014-02-18 Ethicon Endo-Surgery, Inc. Surgical instrument with wireless communication between control unit and sensor transponders
US8684253B2 (en) 2007-01-10 2014-04-01 Ethicon Endo-Surgery, Inc. Surgical instrument with wireless communication between a control unit of a robotic system and remote sensor
US11291441B2 (en) 2007-01-10 2022-04-05 Cilag Gmbh International Surgical instrument with wireless communication between control unit and remote sensor
US11039836B2 (en) 2007-01-11 2021-06-22 Cilag Gmbh International Staple cartridge for use with a surgical stapling instrument
US7434717B2 (en) 2007-01-11 2008-10-14 Ethicon Endo-Surgery, Inc. Apparatus for closing a curved anvil of a surgical stapling device
WO2008147476A1 (en) * 2007-01-23 2008-12-04 Cvdevices, Llc Devices, systems, and methods for endoscopic gastric magnetic restriction
US20090001130A1 (en) 2007-03-15 2009-01-01 Hess Christopher J Surgical procedure using a cutting and stapling instrument having releasable staple-forming pockets
AU2008251300B2 (en) * 2007-05-12 2014-05-29 Boston Scientific Scimed, Inc. Devices and methods for stomach partitioning
US7810691B2 (en) 2007-05-16 2010-10-12 The Invention Science Fund I, Llc Gentle touch surgical stapler
US7798385B2 (en) * 2007-05-16 2010-09-21 The Invention Science Fund I, Llc Surgical stapling instrument with chemical sealant
US8485411B2 (en) 2007-05-16 2013-07-16 The Invention Science Fund I, Llc Gentle touch surgical stapler
US7832611B2 (en) 2007-05-16 2010-11-16 The Invention Science Fund I, Llc Steerable surgical stapler
US7922064B2 (en) * 2007-05-16 2011-04-12 The Invention Science Fund, I, LLC Surgical fastening device with cutter
US7823761B2 (en) 2007-05-16 2010-11-02 The Invention Science Fund I, Llc Maneuverable surgical stapler
EP2155110B1 (en) * 2007-05-25 2017-01-04 Gorham Enterprises Llc Bariatric magnetic apparatus and method of manufacturing thereof
US8931682B2 (en) 2007-06-04 2015-01-13 Ethicon Endo-Surgery, Inc. Robotically-controlled shaft based rotary drive systems for surgical instruments
US11672531B2 (en) 2007-06-04 2023-06-13 Cilag Gmbh International Rotary drive systems for surgical instruments
US7753245B2 (en) 2007-06-22 2010-07-13 Ethicon Endo-Surgery, Inc. Surgical stapling instruments
US8784338B2 (en) 2007-06-22 2014-07-22 Covidien Lp Electrical means to normalize ablational energy transmission to a luminal tissue surface of varying size
US11849941B2 (en) 2007-06-29 2023-12-26 Cilag Gmbh International Staple cartridge having staple cavities extending at a transverse angle relative to a longitudinal cartridge axis
US20090012542A1 (en) * 2007-07-03 2009-01-08 Synecor, Llc Satiation devices and methods for controlling obesity
EP2162090A1 (en) * 2007-07-04 2010-03-17 Nanopowers S.A. Artificial contractile structure and apparatus comprising such structure
KR101547931B1 (en) 2007-07-06 2015-08-28 코비디엔 엘피 Ablation in the gastrointestinal tract to achieve hemostasis and eradicate lesions with a propensity for bleeding
WO2009009443A1 (en) * 2007-07-06 2009-01-15 Barrx Medical, Inc. Method and apparatus for gastrointestinal tract ablation to achieve loss of persistent and/or recurrent excess body weight following a weight-loss operation
US8273012B2 (en) * 2007-07-30 2012-09-25 Tyco Healthcare Group, Lp Cleaning device and methods
US8646460B2 (en) * 2007-07-30 2014-02-11 Covidien Lp Cleaning device and methods
US20100191264A1 (en) * 2007-09-21 2010-07-29 Cvd Devices, Llc Devices, systems and methods for diagnosing and delivering therapeutic interventions in the peritoneal cavity
US9301761B2 (en) * 2007-10-22 2016-04-05 James E. Coleman Anastomosis devices and methods
US20100298953A1 (en) * 2007-10-31 2010-11-25 Vanderbilt University Device and method for positioning a surgical prosthesis
US7866527B2 (en) 2008-02-14 2011-01-11 Ethicon Endo-Surgery, Inc. Surgical stapling apparatus with interlockable firing system
US9179912B2 (en) 2008-02-14 2015-11-10 Ethicon Endo-Surgery, Inc. Robotically-controlled motorized surgical cutting and fastening instrument
US8636736B2 (en) 2008-02-14 2014-01-28 Ethicon Endo-Surgery, Inc. Motorized surgical cutting and fastening instrument
RU2493788C2 (en) 2008-02-14 2013-09-27 Этикон Эндо-Серджери, Инк. Surgical cutting and fixing instrument, which has radio-frequency electrodes
US8573465B2 (en) 2008-02-14 2013-11-05 Ethicon Endo-Surgery, Inc. Robotically-controlled surgical end effector system with rotary actuated closure systems
US7819298B2 (en) 2008-02-14 2010-10-26 Ethicon Endo-Surgery, Inc. Surgical stapling apparatus with control features operable with one hand
US9585657B2 (en) 2008-02-15 2017-03-07 Ethicon Endo-Surgery, Llc Actuator for releasing a layer of material from a surgical end effector
WO2009132072A2 (en) * 2008-04-22 2009-10-29 Ethicon Endo-Surgery, Inc. Methods and devices for dissecting tissue
US8163010B1 (en) * 2008-06-03 2012-04-24 Cardica, Inc. Staple-based heart valve treatment
WO2010005436A1 (en) * 2008-07-10 2010-01-14 Sachasin Rachadip S Minimally invasive percutaneous restrictive bariatric procedure and related device
WO2010011661A1 (en) * 2008-07-21 2010-01-28 Atricure, Inc. Apparatus and methods for occluding an anatomical structure
US20100023022A1 (en) * 2008-07-25 2010-01-28 Zeiner Mark S Reloadable laparoscopic fastener deploying device with disposable cartridge use in a gastric volume reduction procedure
US20100023024A1 (en) * 2008-07-25 2010-01-28 Zeiner Mark S Reloadable laparoscopic fastener deploying device with disposable cartridge for use in a gastric volume reduction procedure
US20100023026A1 (en) * 2008-07-25 2010-01-28 Zeiner Mark S Reloadable laparoscopic fastener deploying device with disposable cartridge for use in a gastric volume reduction procedure
US20100023025A1 (en) * 2008-07-25 2010-01-28 Zeiner Mark S Reloadable laparoscopic fastener deploying device with disposable cartridge for use in a gastric volume reduction procedure
US8828090B2 (en) * 2008-08-13 2014-09-09 Binerix Medical Ltd. Liner for tubular body portion and apparatus and methods for application thereof
US20110264234A1 (en) * 2008-08-21 2011-10-27 Sentinel Group, Llc Gastro-esophageal reflux disease reduction device and method
US20100069924A1 (en) * 2008-09-11 2010-03-18 Wilson-Cook Medical Inc. Methods for achieving serosa-to-serosa closure of a bodily opening using one or more tacking devices
US9386983B2 (en) 2008-09-23 2016-07-12 Ethicon Endo-Surgery, Llc Robotically-controlled motorized surgical instrument
US9005230B2 (en) 2008-09-23 2015-04-14 Ethicon Endo-Surgery, Inc. Motorized surgical instrument
US11648005B2 (en) 2008-09-23 2023-05-16 Cilag Gmbh International Robotically-controlled motorized surgical instrument with an end effector
US8210411B2 (en) 2008-09-23 2012-07-03 Ethicon Endo-Surgery, Inc. Motor-driven surgical cutting instrument
US8608045B2 (en) 2008-10-10 2013-12-17 Ethicon Endo-Sugery, Inc. Powered surgical cutting and stapling apparatus with manually retractable firing system
US8197498B2 (en) 2008-11-06 2012-06-12 Trinitas Ventures Ltd. Gastric bypass devices and procedures
WO2010075569A1 (en) * 2008-12-24 2010-07-01 Boston Scientific Scimed, Inc. Methods of surgically modifying the duodenum
US8517239B2 (en) 2009-02-05 2013-08-27 Ethicon Endo-Surgery, Inc. Surgical stapling instrument comprising a magnetic element driver
RU2525225C2 (en) 2009-02-06 2014-08-10 Этикон Эндо-Серджери, Инк. Improvement of drive surgical suturing instrument
US20100241068A1 (en) * 2009-03-20 2010-09-23 Wei-Hui Chen Vascular cannula assembly with an improved structure for confining blood flow
US20100256672A1 (en) * 2009-04-01 2010-10-07 Weinberg Medical Physics Llc Apparatus and method for wound weaving and healing
US8043248B2 (en) * 2009-04-02 2011-10-25 The Board Of Trustees Of The Leland Stanford Junior University Method for securing a barrier device within the gastrointestinal tract and integral component for same
US20100276469A1 (en) * 2009-05-01 2010-11-04 Barosense, Inc. Plication tagging device and method
US8591396B2 (en) * 2009-05-04 2013-11-26 Covidien Lp Magnetic gastric reduction device
US20110144560A1 (en) 2009-07-15 2011-06-16 Medical And Surgical Review, P.C. Incisionless Gastric Bypass Method And Devices
US8348929B2 (en) 2009-08-05 2013-01-08 Rocin Laboratories, Inc. Endoscopically-guided tissue aspiration system for safely removing fat tissue from a patient
US8465471B2 (en) 2009-08-05 2013-06-18 Rocin Laboratories, Inc. Endoscopically-guided electro-cauterizing power-assisted fat aspiration system for aspirating visceral fat tissue within the abdomen of a patient
US10052220B2 (en) * 2009-10-09 2018-08-21 Boston Scientific Scimed, Inc. Stomach bypass for the treatment of obesity
AU2010308498B2 (en) 2009-10-21 2016-02-11 Apollo Endosurgery, Inc. Bariatric device and method for weight loss
US20120022319A1 (en) * 2009-11-25 2012-01-26 David Muller Systems and Methods For Reducing Gastric Volume
US8851354B2 (en) 2009-12-24 2014-10-07 Ethicon Endo-Surgery, Inc. Surgical cutting instrument that analyzes tissue thickness
US8870898B2 (en) 2010-01-05 2014-10-28 GI Windows, Inc. Self-assembling magnetic anastomosis device having an exoskeleton
US8328061B2 (en) 2010-02-02 2012-12-11 Covidien Lp Surgical instrument for joining tissue
ES2536055T3 (en) 2010-03-15 2015-05-20 Apollo Endosurgery, Inc. Bariatric device and weight loss method
US8585628B2 (en) * 2010-05-26 2013-11-19 Ethicon Endo-Surgery, Inc. Methods and devices for regulating the activation of ghrelin hormones within a stomach
US8636751B2 (en) 2010-05-26 2014-01-28 Ethicon Endo-Surgery, Inc. Methods and devices for the rerouting of chyme to induce intestinal brake
US20110295056A1 (en) * 2010-05-26 2011-12-01 Aldridge Jeffrey L Systems and methods for gastric volume regulation
US8783543B2 (en) 2010-07-30 2014-07-22 Ethicon Endo-Surgery, Inc. Tissue acquisition arrangements and methods for surgical stapling devices
GB2482749A (en) 2010-08-10 2012-02-15 Yissum Res Dev Co An adapter for supporting gastric devices.
US9629814B2 (en) 2010-09-30 2017-04-25 Ethicon Endo-Surgery, Llc Tissue thickness compensator configured to redistribute compressive forces
US8857694B2 (en) 2010-09-30 2014-10-14 Ethicon Endo-Surgery, Inc. Staple cartridge loading assembly
US11812965B2 (en) 2010-09-30 2023-11-14 Cilag Gmbh International Layer of material for a surgical end effector
US9839420B2 (en) 2010-09-30 2017-12-12 Ethicon Llc Tissue thickness compensator comprising at least one medicament
US11298125B2 (en) 2010-09-30 2022-04-12 Cilag Gmbh International Tissue stapler having a thickness compensator
US11849952B2 (en) 2010-09-30 2023-12-26 Cilag Gmbh International Staple cartridge comprising staples positioned within a compressible portion thereof
US10945731B2 (en) 2010-09-30 2021-03-16 Ethicon Llc Tissue thickness compensator comprising controlled release and expansion
US9700317B2 (en) 2010-09-30 2017-07-11 Ethicon Endo-Surgery, Llc Fastener cartridge comprising a releasable tissue thickness compensator
US8695866B2 (en) 2010-10-01 2014-04-15 Ethicon Endo-Surgery, Inc. Surgical instrument having a power control circuit
ES2565348T3 (en) 2010-10-18 2016-04-04 Apollo Endosurgery, Inc. Intragastric implant reagent devices
WO2012054514A2 (en) 2010-10-18 2012-04-26 Allergan, Inc. Intragastric implants with duodenal anchors
US9463107B2 (en) 2010-10-18 2016-10-11 Apollo Endosurgery, Inc. Variable size intragastric implant devices
US8870966B2 (en) 2010-10-18 2014-10-28 Apollo Endosurgery, Inc. Intragastric balloon for treating obesity
US9233016B2 (en) 2010-10-18 2016-01-12 Apollo Endosurgery, Inc. Elevating stomach stimulation device
US9498365B2 (en) 2010-10-19 2016-11-22 Apollo Endosurgery, Inc. Intragastric implants with multiple fluid chambers
US9095405B2 (en) 2010-10-19 2015-08-04 Apollo Endosurgery, Inc. Space-filling intragastric implants with fluid flow
US9398969B2 (en) 2010-10-19 2016-07-26 Apollo Endosurgery, Inc. Upper stomach gastric implants
US8864840B2 (en) 2010-10-19 2014-10-21 Apollo Endosurgery, Inc. Intragastric implants with collapsible frames
US8920447B2 (en) * 2010-10-19 2014-12-30 Apollo Endosurgery, Inc. Articulated gastric implant clip
ES2593753T3 (en) 2010-10-19 2016-12-13 Apollo Endosurgery, Inc. Duodenal sleeve with anchor without perforation
US9198790B2 (en) 2010-10-19 2015-12-01 Apollo Endosurgery, Inc. Upper stomach gastric implants
US9017349B2 (en) 2010-10-27 2015-04-28 Atricure, Inc. Appendage clamp deployment assist device
JP2014511218A (en) 2011-02-01 2014-05-15 セント・ジュード・メディカル,インコーポレイテッド Apparatus and method for heart valve repair
US10278774B2 (en) 2011-03-18 2019-05-07 Covidien Lp Selectively expandable operative element support structure and methods of use
AU2012250197B2 (en) 2011-04-29 2017-08-10 Ethicon Endo-Surgery, Inc. Staple cartridge comprising staples positioned within a compressible portion thereof
US9072535B2 (en) 2011-05-27 2015-07-07 Ethicon Endo-Surgery, Inc. Surgical stapling instruments with rotatable staple deployment arrangements
US11207064B2 (en) 2011-05-27 2021-12-28 Cilag Gmbh International Automated end effector component reloading system for use with a robotic system
US9572571B2 (en) * 2011-09-09 2017-02-21 Endogastric Solutions, Inc. Methods and devices for manipulating and fastening tissue
US8814025B2 (en) * 2011-09-15 2014-08-26 Ethicon Endo-Surgery, Inc. Fibrin pad matrix with suspended heat activated beads of adhesive
US9247930B2 (en) 2011-12-21 2016-02-02 James E. Coleman Devices and methods for occluding or promoting fluid flow
WO2013112795A1 (en) 2012-01-25 2013-08-01 St. Jude Medical, Inc. Apparatus and method for heart valve repair
WO2013112797A2 (en) 2012-01-25 2013-08-01 St. Jude Medical, Inc. Apparatus and method for heart valve repair
WO2013116617A1 (en) 2012-02-02 2013-08-08 St. Jude Medical, Cardiology Division, Inc. Apparatus and method for heart valve repair
MX358135B (en) 2012-03-28 2018-08-06 Ethicon Endo Surgery Inc Tissue thickness compensator comprising a plurality of layers.
MX350846B (en) 2012-03-28 2017-09-22 Ethicon Endo Surgery Inc Tissue thickness compensator comprising capsules defining a low pressure environment.
CN104379068B (en) 2012-03-28 2017-09-22 伊西康内外科公司 Holding device assembly including tissue thickness compensation part
GB2517363B (en) * 2012-06-05 2016-02-24 Mayank Goyal Systems and methods for enhancing preparation and completion of surgical and medical procedures
US9042596B2 (en) 2012-06-14 2015-05-26 Medibotics Llc Willpower watch (TM)—a wearable food consumption monitor
US9254099B2 (en) 2013-05-23 2016-02-09 Medibotics Llc Smart watch and food-imaging member for monitoring food consumption
US9442100B2 (en) 2013-12-18 2016-09-13 Medibotics Llc Caloric intake measuring system using spectroscopic and 3D imaging analysis
US9536449B2 (en) 2013-05-23 2017-01-03 Medibotics Llc Smart watch and food utensil for monitoring food consumption
US9101358B2 (en) 2012-06-15 2015-08-11 Ethicon Endo-Surgery, Inc. Articulatable surgical instrument comprising a firing drive
BR112014032776B1 (en) 2012-06-28 2021-09-08 Ethicon Endo-Surgery, Inc SURGICAL INSTRUMENT SYSTEM AND SURGICAL KIT FOR USE WITH A SURGICAL INSTRUMENT SYSTEM
US20140001231A1 (en) 2012-06-28 2014-01-02 Ethicon Endo-Surgery, Inc. Firing system lockout arrangements for surgical instruments
JP6290201B2 (en) 2012-06-28 2018-03-07 エシコン・エンド−サージェリィ・インコーポレイテッドEthicon Endo−Surgery,Inc. Lockout for empty clip cartridge
US9289256B2 (en) 2012-06-28 2016-03-22 Ethicon Endo-Surgery, Llc Surgical end effectors having angled tissue-contacting surfaces
US11202631B2 (en) 2012-06-28 2021-12-21 Cilag Gmbh International Stapling assembly comprising a firing lockout
US9649111B2 (en) 2012-06-28 2017-05-16 Ethicon Endo-Surgery, Llc Replaceable clip cartridge for a clip applier
US20140005678A1 (en) 2012-06-28 2014-01-02 Ethicon Endo-Surgery, Inc. Rotary drive arrangements for surgical instruments
US10105219B2 (en) 2012-08-02 2018-10-23 St. Jude Medical, Cardiology Division, Inc. Mitral valve leaflet clip
US9662205B2 (en) 2012-08-02 2017-05-30 St. Jude Medical, Cardiology Division, Inc. Apparatus and method for heart valve repair
US9750595B2 (en) 2012-09-28 2017-09-05 Covidien Lp Implantable medical devices which include grip-members and methods of use thereof
US9999533B2 (en) 2012-11-29 2018-06-19 Boehringer Laboratories, Inc. Gastric sizing systems including instruments for use in bariatric surgery
US10646625B2 (en) 2012-11-29 2020-05-12 Boehringer Laboratories, Inc. Gastric sizing systems including instruments for use in bariatric surgery
MX364729B (en) 2013-03-01 2019-05-06 Ethicon Endo Surgery Inc Surgical instrument with a soft stop.
JP6382235B2 (en) 2013-03-01 2018-08-29 エシコン・エンド−サージェリィ・インコーポレイテッドEthicon Endo−Surgery,Inc. Articulatable surgical instrument with a conductive path for signal communication
US9642706B2 (en) * 2013-03-11 2017-05-09 St. Jude Medical, Llc Apparatus and method for heart valve repair
US9629629B2 (en) 2013-03-14 2017-04-25 Ethicon Endo-Surgey, LLC Control systems for surgical instruments
US20140276991A1 (en) * 2013-03-15 2014-09-18 The Cleveland Clinic Foundation Gastric plication guide
US9826976B2 (en) 2013-04-16 2017-11-28 Ethicon Llc Motor driven surgical instruments with lockable dual drive shafts
BR112015026109B1 (en) 2013-04-16 2022-02-22 Ethicon Endo-Surgery, Inc surgical instrument
US9529385B2 (en) 2013-05-23 2016-12-27 Medibotics Llc Smart watch and human-to-computer interface for monitoring food consumption
US9808249B2 (en) 2013-08-23 2017-11-07 Ethicon Llc Attachment portions for surgical instrument assemblies
MX369362B (en) 2013-08-23 2019-11-06 Ethicon Endo Surgery Llc Firing member retraction devices for powered surgical instruments.
ES2815566T3 (en) 2013-10-10 2021-03-30 Nitinotes Ltd Endoluminal sleeve gastroplasty
US10779979B2 (en) 2013-10-10 2020-09-22 Nitinotes Ltd. Endoluminal sleeve gastroplasty
US20150126983A1 (en) * 2013-11-05 2015-05-07 Apollo Endosurgery, Inc. Incisionless Endoluminal Gastric Tissue Approximation for the Treatment Of Obesity
US9962161B2 (en) 2014-02-12 2018-05-08 Ethicon Llc Deliverable surgical instrument
US20150250474A1 (en) 2014-03-04 2015-09-10 Maquet Cardiovascular Llc Surgical implant and method and instrument for installing the same
US10499908B2 (en) 2014-03-04 2019-12-10 Maquet Cardiovascular Llc Surgical implant and method and instrument for installing the same
US20150272557A1 (en) 2014-03-26 2015-10-01 Ethicon Endo-Surgery, Inc. Modular surgical instrument system
US9826977B2 (en) 2014-03-26 2017-11-28 Ethicon Llc Sterilization verification circuit
BR112016021943B1 (en) 2014-03-26 2022-06-14 Ethicon Endo-Surgery, Llc SURGICAL INSTRUMENT FOR USE BY AN OPERATOR IN A SURGICAL PROCEDURE
US10542988B2 (en) 2014-04-16 2020-01-28 Ethicon Llc End effector comprising an anvil including projections extending therefrom
JP6612256B2 (en) 2014-04-16 2019-11-27 エシコン エルエルシー Fastener cartridge with non-uniform fastener
BR112016023807B1 (en) 2014-04-16 2022-07-12 Ethicon Endo-Surgery, Llc CARTRIDGE SET OF FASTENERS FOR USE WITH A SURGICAL INSTRUMENT
US20150297223A1 (en) 2014-04-16 2015-10-22 Ethicon Endo-Surgery, Inc. Fastener cartridges including extensions having different configurations
CN106456176B (en) 2014-04-16 2019-06-28 伊西康内外科有限责任公司 Fastener cartridge including the extension with various configuration
ES2861258T3 (en) * 2014-06-11 2021-10-06 Applied Med Resources Circumferential Shot Surgical Stapler
US9730694B2 (en) * 2014-07-01 2017-08-15 Covidien Lp Loading unit including shipping assembly
US9629741B2 (en) * 2014-07-18 2017-04-25 Covidien Lp Gastric tubes and methods of use
BR112017004361B1 (en) 2014-09-05 2023-04-11 Ethicon Llc ELECTRONIC SYSTEM FOR A SURGICAL INSTRUMENT
US9724094B2 (en) 2014-09-05 2017-08-08 Ethicon Llc Adjunct with integrated sensors to quantify tissue compression
US11311294B2 (en) 2014-09-05 2022-04-26 Cilag Gmbh International Powered medical device including measurement of closure state of jaws
US10105142B2 (en) 2014-09-18 2018-10-23 Ethicon Llc Surgical stapler with plurality of cutting elements
US11523821B2 (en) 2014-09-26 2022-12-13 Cilag Gmbh International Method for creating a flexible staple line
CN107427300B (en) 2014-09-26 2020-12-04 伊西康有限责任公司 Surgical suture buttress and buttress material
US9924944B2 (en) 2014-10-16 2018-03-27 Ethicon Llc Staple cartridge comprising an adjunct material
US10517594B2 (en) 2014-10-29 2019-12-31 Ethicon Llc Cartridge assemblies for surgical staplers
US11141153B2 (en) 2014-10-29 2021-10-12 Cilag Gmbh International Staple cartridges comprising driver arrangements
US9844376B2 (en) 2014-11-06 2017-12-19 Ethicon Llc Staple cartridge comprising a releasable adjunct material
US10736636B2 (en) 2014-12-10 2020-08-11 Ethicon Llc Articulatable surgical instrument system
US10245027B2 (en) 2014-12-18 2019-04-02 Ethicon Llc Surgical instrument with an anvil that is selectively movable about a discrete non-movable axis relative to a staple cartridge
US9844375B2 (en) 2014-12-18 2017-12-19 Ethicon Llc Drive arrangements for articulatable surgical instruments
BR112017012996B1 (en) 2014-12-18 2022-11-08 Ethicon Llc SURGICAL INSTRUMENT WITH AN ANvil WHICH IS SELECTIVELY MOVABLE ABOUT AN IMMOVABLE GEOMETRIC AXIS DIFFERENT FROM A STAPLE CARTRIDGE
US9987000B2 (en) 2014-12-18 2018-06-05 Ethicon Llc Surgical instrument assembly comprising a flexible articulation system
US9844374B2 (en) 2014-12-18 2017-12-19 Ethicon Llc Surgical instrument systems comprising an articulatable end effector and means for adjusting the firing stroke of a firing member
US10085748B2 (en) 2014-12-18 2018-10-02 Ethicon Llc Locking arrangements for detachable shaft assemblies with articulatable surgical end effectors
US11154301B2 (en) 2015-02-27 2021-10-26 Cilag Gmbh International Modular stapling assembly
JP2020121162A (en) 2015-03-06 2020-08-13 エシコン エルエルシーEthicon LLC Time dependent evaluation of sensor data to determine stability element, creep element and viscoelastic element of measurement
US9993248B2 (en) 2015-03-06 2018-06-12 Ethicon Endo-Surgery, Llc Smart sensors with local signal processing
US10052044B2 (en) 2015-03-06 2018-08-21 Ethicon Llc Time dependent evaluation of sensor data to determine stability, creep, and viscoelastic elements of measures
US10245033B2 (en) 2015-03-06 2019-04-02 Ethicon Llc Surgical instrument comprising a lockable battery housing
US11058425B2 (en) 2015-08-17 2021-07-13 Ethicon Llc Implantable layers for a surgical instrument
WO2017041052A1 (en) * 2015-09-03 2017-03-09 Neptune Medical Device for endoscopic advancement through the small intestine
CA2998170C (en) 2015-09-15 2023-10-03 Savage Medical, Inc. Devices and methods for anchoring a sheath in a tissue cavity
US10238386B2 (en) 2015-09-23 2019-03-26 Ethicon Llc Surgical stapler having motor control based on an electrical parameter related to a motor current
US10105139B2 (en) 2015-09-23 2018-10-23 Ethicon Llc Surgical stapler having downstream current-based motor control
US10299878B2 (en) 2015-09-25 2019-05-28 Ethicon Llc Implantable adjunct systems for determining adjunct skew
US11890015B2 (en) 2015-09-30 2024-02-06 Cilag Gmbh International Compressible adjunct with crossing spacer fibers
US10524788B2 (en) 2015-09-30 2020-01-07 Ethicon Llc Compressible adjunct with attachment regions
US10980539B2 (en) 2015-09-30 2021-04-20 Ethicon Llc Implantable adjunct comprising bonded layers
US10285699B2 (en) 2015-09-30 2019-05-14 Ethicon Llc Compressible adjunct
US10265068B2 (en) 2015-12-30 2019-04-23 Ethicon Llc Surgical instruments with separable motors and motor control circuits
US10292704B2 (en) 2015-12-30 2019-05-21 Ethicon Llc Mechanisms for compensating for battery pack failure in powered surgical instruments
US10368865B2 (en) 2015-12-30 2019-08-06 Ethicon Llc Mechanisms for compensating for drivetrain failure in powered surgical instruments
US11213293B2 (en) 2016-02-09 2022-01-04 Cilag Gmbh International Articulatable surgical instruments with single articulation link arrangements
BR112018016098B1 (en) 2016-02-09 2023-02-23 Ethicon Llc SURGICAL INSTRUMENT
US10448948B2 (en) 2016-02-12 2019-10-22 Ethicon Llc Mechanisms for compensating for drivetrain failure in powered surgical instruments
US11224426B2 (en) 2016-02-12 2022-01-18 Cilag Gmbh International Mechanisms for compensating for drivetrain failure in powered surgical instruments
US11607239B2 (en) 2016-04-15 2023-03-21 Cilag Gmbh International Systems and methods for controlling a surgical stapling and cutting instrument
US10357247B2 (en) 2016-04-15 2019-07-23 Ethicon Llc Surgical instrument with multiple program responses during a firing motion
US10492783B2 (en) 2016-04-15 2019-12-03 Ethicon, Llc Surgical instrument with improved stop/start control during a firing motion
US10426467B2 (en) 2016-04-15 2019-10-01 Ethicon Llc Surgical instrument with detection sensors
US10335145B2 (en) 2016-04-15 2019-07-02 Ethicon Llc Modular surgical instrument with configurable operating mode
US10828028B2 (en) 2016-04-15 2020-11-10 Ethicon Llc Surgical instrument with multiple program responses during a firing motion
US11179150B2 (en) 2016-04-15 2021-11-23 Cilag Gmbh International Systems and methods for controlling a surgical stapling and cutting instrument
US10456137B2 (en) 2016-04-15 2019-10-29 Ethicon Llc Staple formation detection mechanisms
US10363037B2 (en) 2016-04-18 2019-07-30 Ethicon Llc Surgical instrument system comprising a magnetic lockout
US11317917B2 (en) 2016-04-18 2022-05-03 Cilag Gmbh International Surgical stapling system comprising a lockable firing assembly
US20170296173A1 (en) 2016-04-18 2017-10-19 Ethicon Endo-Surgery, Llc Method for operating a surgical instrument
EP3487418A4 (en) 2016-07-25 2020-04-08 Virender K. Sharma Magnetic anastomosis device delivery system
US11304698B2 (en) 2016-07-25 2022-04-19 Virender K. Sharma Cardiac shunt device and delivery system
US11122971B2 (en) 2016-08-18 2021-09-21 Neptune Medical Inc. Device and method for enhanced visualization of the small intestine
US10588769B2 (en) 2016-10-12 2020-03-17 Ethicon, Inc. Caloric bypass device
CN110099619B (en) 2016-12-21 2022-07-15 爱惜康有限责任公司 Lockout device for surgical end effector and replaceable tool assembly
US10667810B2 (en) 2016-12-21 2020-06-02 Ethicon Llc Closure members with cam surface arrangements for surgical instruments with separate and distinct closure and firing systems
US10675025B2 (en) 2016-12-21 2020-06-09 Ethicon Llc Shaft assembly comprising separately actuatable and retractable systems
US11419606B2 (en) 2016-12-21 2022-08-23 Cilag Gmbh International Shaft assembly comprising a clutch configured to adapt the output of a rotary firing member to two different systems
US10568625B2 (en) 2016-12-21 2020-02-25 Ethicon Llc Staple cartridges and arrangements of staples and staple cavities therein
US11090048B2 (en) 2016-12-21 2021-08-17 Cilag Gmbh International Method for resetting a fuse of a surgical instrument shaft
BR112019011947A2 (en) 2016-12-21 2019-10-29 Ethicon Llc surgical stapling systems
US10568626B2 (en) 2016-12-21 2020-02-25 Ethicon Llc Surgical instruments with jaw opening features for increasing a jaw opening distance
US11134942B2 (en) 2016-12-21 2021-10-05 Cilag Gmbh International Surgical stapling instruments and staple-forming anvils
US10973516B2 (en) 2016-12-21 2021-04-13 Ethicon Llc Surgical end effectors and adaptable firing members therefor
US10959727B2 (en) 2016-12-21 2021-03-30 Ethicon Llc Articulatable surgical end effector with asymmetric shaft arrangement
US20180168615A1 (en) 2016-12-21 2018-06-21 Ethicon Endo-Surgery, Llc Method of deforming staples from two different types of staple cartridges with the same surgical stapling instrument
JP7010956B2 (en) 2016-12-21 2022-01-26 エシコン エルエルシー How to staple tissue
US20180168598A1 (en) 2016-12-21 2018-06-21 Ethicon Endo-Surgery, Llc Staple forming pocket arrangements comprising zoned forming surface grooves
WO2018132549A1 (en) 2017-01-11 2018-07-19 Sharma Virender K Cardiac shunt device and delivery system
US10548753B2 (en) 2017-01-13 2020-02-04 Ethicon, Inc. Passive caloric bypass device
US20180221052A1 (en) * 2017-02-02 2018-08-09 Galen Ohnmacht Anti-fouling cannulas for endoscopic ports
US10779820B2 (en) 2017-06-20 2020-09-22 Ethicon Llc Systems and methods for controlling motor speed according to user input for a surgical instrument
US10881399B2 (en) 2017-06-20 2021-01-05 Ethicon Llc Techniques for adaptive control of motor velocity of a surgical stapling and cutting instrument
US10307170B2 (en) 2017-06-20 2019-06-04 Ethicon Llc Method for closed loop control of motor velocity of a surgical stapling and cutting instrument
US11517325B2 (en) 2017-06-20 2022-12-06 Cilag Gmbh International Closed loop feedback control of motor velocity of a surgical stapling and cutting instrument based on measured displacement distance traveled over a specified time interval
US11653914B2 (en) 2017-06-20 2023-05-23 Cilag Gmbh International Systems and methods for controlling motor velocity of a surgical stapling and cutting instrument according to articulation angle of end effector
US11071554B2 (en) 2017-06-20 2021-07-27 Cilag Gmbh International Closed loop feedback control of motor velocity of a surgical stapling and cutting instrument based on magnitude of velocity error measurements
US11382638B2 (en) 2017-06-20 2022-07-12 Cilag Gmbh International Closed loop feedback control of motor velocity of a surgical stapling and cutting instrument based on measured time over a specified displacement distance
US11090046B2 (en) 2017-06-20 2021-08-17 Cilag Gmbh International Systems and methods for controlling displacement member motion of a surgical stapling and cutting instrument
US10980537B2 (en) 2017-06-20 2021-04-20 Ethicon Llc Closed loop feedback control of motor velocity of a surgical stapling and cutting instrument based on measured time over a specified number of shaft rotations
US11324503B2 (en) 2017-06-27 2022-05-10 Cilag Gmbh International Surgical firing member arrangements
US20180368844A1 (en) 2017-06-27 2018-12-27 Ethicon Llc Staple forming pocket arrangements
US10993716B2 (en) 2017-06-27 2021-05-04 Ethicon Llc Surgical anvil arrangements
US11266405B2 (en) 2017-06-27 2022-03-08 Cilag Gmbh International Surgical anvil manufacturing methods
EP4070740A1 (en) 2017-06-28 2022-10-12 Cilag GmbH International Surgical instrument comprising selectively actuatable rotatable couplers
US11259805B2 (en) 2017-06-28 2022-03-01 Cilag Gmbh International Surgical instrument comprising firing member supports
US11389161B2 (en) 2017-06-28 2022-07-19 Cilag Gmbh International Surgical instrument comprising selectively actuatable rotatable couplers
US11478242B2 (en) 2017-06-28 2022-10-25 Cilag Gmbh International Jaw retainer arrangement for retaining a pivotable surgical instrument jaw in pivotable retaining engagement with a second surgical instrument jaw
US10903685B2 (en) 2017-06-28 2021-01-26 Ethicon Llc Surgical shaft assemblies with slip ring assemblies forming capacitive channels
US11564686B2 (en) 2017-06-28 2023-01-31 Cilag Gmbh International Surgical shaft assemblies with flexible interfaces
US10765427B2 (en) 2017-06-28 2020-09-08 Ethicon Llc Method for articulating a surgical instrument
US11246592B2 (en) 2017-06-28 2022-02-15 Cilag Gmbh International Surgical instrument comprising an articulation system lockable to a frame
US10932772B2 (en) 2017-06-29 2021-03-02 Ethicon Llc Methods for closed loop velocity control for robotic surgical instrument
EP3644865A4 (en) 2017-06-30 2021-03-03 The Regents of The University of California Magnetic devices, systems, and methods
US11471155B2 (en) 2017-08-03 2022-10-18 Cilag Gmbh International Surgical system bailout
US11304695B2 (en) 2017-08-03 2022-04-19 Cilag Gmbh International Surgical system shaft interconnection
KR102005238B1 (en) * 2017-08-08 2019-07-30 김재황 Auto tension measuring instrument
US11399829B2 (en) 2017-09-29 2022-08-02 Cilag Gmbh International Systems and methods of initiating a power shutdown mode for a surgical instrument
US11134944B2 (en) 2017-10-30 2021-10-05 Cilag Gmbh International Surgical stapler knife motion controls
US11090075B2 (en) 2017-10-30 2021-08-17 Cilag Gmbh International Articulation features for surgical end effector
US10842490B2 (en) 2017-10-31 2020-11-24 Ethicon Llc Cartridge body design with force reduction based on firing completion
DE102017129908A1 (en) * 2017-12-14 2019-06-19 Knorr-Bremse Systeme für Nutzfahrzeuge GmbH Arrangement for a commercial vehicle
US11071543B2 (en) 2017-12-15 2021-07-27 Cilag Gmbh International Surgical end effectors with clamping assemblies configured to increase jaw aperture ranges
US11197670B2 (en) 2017-12-15 2021-12-14 Cilag Gmbh International Surgical end effectors with pivotal jaws configured to touch at their respective distal ends when fully closed
US11033267B2 (en) 2017-12-15 2021-06-15 Ethicon Llc Systems and methods of controlling a clamping member firing rate of a surgical instrument
US10966718B2 (en) 2017-12-15 2021-04-06 Ethicon Llc Dynamic clamping assemblies with improved wear characteristics for use in connection with electromechanical surgical instruments
US10779826B2 (en) 2017-12-15 2020-09-22 Ethicon Llc Methods of operating surgical end effectors
US11020112B2 (en) 2017-12-19 2021-06-01 Ethicon Llc Surgical tools configured for interchangeable use with different controller interfaces
USD910847S1 (en) 2017-12-19 2021-02-16 Ethicon Llc Surgical instrument assembly
US10835330B2 (en) 2017-12-19 2020-11-17 Ethicon Llc Method for determining the position of a rotatable jaw of a surgical instrument attachment assembly
US11311290B2 (en) 2017-12-21 2022-04-26 Cilag Gmbh International Surgical instrument comprising an end effector dampener
US11076853B2 (en) 2017-12-21 2021-08-03 Cilag Gmbh International Systems and methods of displaying a knife position during transection for a surgical instrument
US10682134B2 (en) 2017-12-21 2020-06-16 Ethicon Llc Continuous use self-propelled stapling instrument
US11129680B2 (en) 2017-12-21 2021-09-28 Cilag Gmbh International Surgical instrument comprising a projector
EP4282361A3 (en) * 2018-05-15 2024-03-06 Ballast Medical Inc. Enhanced techniques for insertion and extraction of a bougie during gastroplasty
EP3801299B1 (en) 2018-06-02 2024-01-03 GI Windows Inc. Devices for forming anastomoses
CA3106275A1 (en) 2018-07-19 2020-01-23 Neptune Medical Inc. Dynamically rigidizing composite medical structures
US11253256B2 (en) 2018-08-20 2022-02-22 Cilag Gmbh International Articulatable motor powered surgical instruments with dedicated articulation motor arrangements
US11324501B2 (en) 2018-08-20 2022-05-10 Cilag Gmbh International Surgical stapling devices with improved closure members
US11207065B2 (en) 2018-08-20 2021-12-28 Cilag Gmbh International Method for fabricating surgical stapler anvils
US11045192B2 (en) 2018-08-20 2021-06-29 Cilag Gmbh International Fabricating techniques for surgical stapler anvils
US11039834B2 (en) 2018-08-20 2021-06-22 Cilag Gmbh International Surgical stapler anvils with staple directing protrusions and tissue stability features
US11291440B2 (en) 2018-08-20 2022-04-05 Cilag Gmbh International Method for operating a powered articulatable surgical instrument
US10912559B2 (en) 2018-08-20 2021-02-09 Ethicon Llc Reinforced deformable anvil tip for surgical stapler anvil
US11083458B2 (en) 2018-08-20 2021-08-10 Cilag Gmbh International Powered surgical instruments with clutching arrangements to convert linear drive motions to rotary drive motions
USD914878S1 (en) 2018-08-20 2021-03-30 Ethicon Llc Surgical instrument anvil
US11172929B2 (en) 2019-03-25 2021-11-16 Cilag Gmbh International Articulation drive arrangements for surgical systems
US11147553B2 (en) 2019-03-25 2021-10-19 Cilag Gmbh International Firing drive arrangements for surgical systems
US11696761B2 (en) 2019-03-25 2023-07-11 Cilag Gmbh International Firing drive arrangements for surgical systems
US11147551B2 (en) 2019-03-25 2021-10-19 Cilag Gmbh International Firing drive arrangements for surgical systems
US11793392B2 (en) 2019-04-17 2023-10-24 Neptune Medical Inc. External working channels
US11452528B2 (en) 2019-04-30 2022-09-27 Cilag Gmbh International Articulation actuators for a surgical instrument
US11903581B2 (en) 2019-04-30 2024-02-20 Cilag Gmbh International Methods for stapling tissue using a surgical instrument
US11648009B2 (en) 2019-04-30 2023-05-16 Cilag Gmbh International Rotatable jaw tip for a surgical instrument
US11471157B2 (en) 2019-04-30 2022-10-18 Cilag Gmbh International Articulation control mapping for a surgical instrument
US11432816B2 (en) 2019-04-30 2022-09-06 Cilag Gmbh International Articulation pin for a surgical instrument
US11426251B2 (en) 2019-04-30 2022-08-30 Cilag Gmbh International Articulation directional lights on a surgical instrument
US11253254B2 (en) 2019-04-30 2022-02-22 Cilag Gmbh International Shaft rotation actuator on a surgical instrument
US11576800B2 (en) * 2019-06-14 2023-02-14 Nassar Ismail Low risk, reversible, weight loss procedure
US11497492B2 (en) 2019-06-28 2022-11-15 Cilag Gmbh International Surgical instrument including an articulation lock
US11291451B2 (en) 2019-06-28 2022-04-05 Cilag Gmbh International Surgical instrument with battery compatibility verification functionality
US11464601B2 (en) 2019-06-28 2022-10-11 Cilag Gmbh International Surgical instrument comprising an RFID system for tracking a movable component
US11298132B2 (en) 2019-06-28 2022-04-12 Cilag GmbH Inlernational Staple cartridge including a honeycomb extension
US11478241B2 (en) 2019-06-28 2022-10-25 Cilag Gmbh International Staple cartridge including projections
US11376098B2 (en) 2019-06-28 2022-07-05 Cilag Gmbh International Surgical instrument system comprising an RFID system
US11051807B2 (en) 2019-06-28 2021-07-06 Cilag Gmbh International Packaging assembly including a particulate trap
US11426167B2 (en) 2019-06-28 2022-08-30 Cilag Gmbh International Mechanisms for proper anvil attachment surgical stapling head assembly
US11219455B2 (en) 2019-06-28 2022-01-11 Cilag Gmbh International Surgical instrument including a lockout key
US11259803B2 (en) 2019-06-28 2022-03-01 Cilag Gmbh International Surgical stapling system having an information encryption protocol
US11399837B2 (en) 2019-06-28 2022-08-02 Cilag Gmbh International Mechanisms for motor control adjustments of a motorized surgical instrument
US11241235B2 (en) 2019-06-28 2022-02-08 Cilag Gmbh International Method of using multiple RFID chips with a surgical assembly
US11298127B2 (en) 2019-06-28 2022-04-12 Cilag GmbH Interational Surgical stapling system having a lockout mechanism for an incompatible cartridge
US11684434B2 (en) 2019-06-28 2023-06-27 Cilag Gmbh International Surgical RFID assemblies for instrument operational setting control
US11553971B2 (en) 2019-06-28 2023-01-17 Cilag Gmbh International Surgical RFID assemblies for display and communication
US11224497B2 (en) 2019-06-28 2022-01-18 Cilag Gmbh International Surgical systems with multiple RFID tags
US11771419B2 (en) 2019-06-28 2023-10-03 Cilag Gmbh International Packaging for a replaceable component of a surgical stapling system
US11246678B2 (en) 2019-06-28 2022-02-15 Cilag Gmbh International Surgical stapling system having a frangible RFID tag
US11523822B2 (en) 2019-06-28 2022-12-13 Cilag Gmbh International Battery pack including a circuit interrupter
US11638587B2 (en) 2019-06-28 2023-05-02 Cilag Gmbh International RFID identification systems for surgical instruments
US11660163B2 (en) 2019-06-28 2023-05-30 Cilag Gmbh International Surgical system with RFID tags for updating motor assembly parameters
US11627959B2 (en) 2019-06-28 2023-04-18 Cilag Gmbh International Surgical instruments including manual and powered system lockouts
US11291447B2 (en) 2019-12-19 2022-04-05 Cilag Gmbh International Stapling instrument comprising independent jaw closing and staple firing systems
US11464512B2 (en) 2019-12-19 2022-10-11 Cilag Gmbh International Staple cartridge comprising a curved deck surface
US11529137B2 (en) 2019-12-19 2022-12-20 Cilag Gmbh International Staple cartridge comprising driver retention members
US11234698B2 (en) 2019-12-19 2022-02-01 Cilag Gmbh International Stapling system comprising a clamp lockout and a firing lockout
US11529139B2 (en) 2019-12-19 2022-12-20 Cilag Gmbh International Motor driven surgical instrument
US11559304B2 (en) 2019-12-19 2023-01-24 Cilag Gmbh International Surgical instrument comprising a rapid closure mechanism
US11911032B2 (en) 2019-12-19 2024-02-27 Cilag Gmbh International Staple cartridge comprising a seating cam
US11504122B2 (en) 2019-12-19 2022-11-22 Cilag Gmbh International Surgical instrument comprising a nested firing member
US11844520B2 (en) 2019-12-19 2023-12-19 Cilag Gmbh International Staple cartridge comprising driver retention members
US11576672B2 (en) 2019-12-19 2023-02-14 Cilag Gmbh International Surgical instrument comprising a closure system including a closure member and an opening member driven by a drive screw
US11607219B2 (en) 2019-12-19 2023-03-21 Cilag Gmbh International Staple cartridge comprising a detachable tissue cutting knife
US11446029B2 (en) 2019-12-19 2022-09-20 Cilag Gmbh International Staple cartridge comprising projections extending from a curved deck surface
US11304696B2 (en) 2019-12-19 2022-04-19 Cilag Gmbh International Surgical instrument comprising a powered articulation system
US11701111B2 (en) 2019-12-19 2023-07-18 Cilag Gmbh International Method for operating a surgical stapling instrument
WO2021202336A1 (en) 2020-03-30 2021-10-07 Neptune Medical Inc. Layered walls for rigidizing devices
USD975278S1 (en) 2020-06-02 2023-01-10 Cilag Gmbh International Staple cartridge
USD966512S1 (en) 2020-06-02 2022-10-11 Cilag Gmbh International Staple cartridge
USD967421S1 (en) 2020-06-02 2022-10-18 Cilag Gmbh International Staple cartridge
USD976401S1 (en) 2020-06-02 2023-01-24 Cilag Gmbh International Staple cartridge
USD974560S1 (en) 2020-06-02 2023-01-03 Cilag Gmbh International Staple cartridge
USD975851S1 (en) 2020-06-02 2023-01-17 Cilag Gmbh International Staple cartridge
USD975850S1 (en) 2020-06-02 2023-01-17 Cilag Gmbh International Staple cartridge
US11737748B2 (en) 2020-07-28 2023-08-29 Cilag Gmbh International Surgical instruments with double spherical articulation joints with pivotable links
US11576676B2 (en) 2020-09-18 2023-02-14 Gt Metabolic Solutions, Inc. Anastomosis formation with magnetic devices having temporary retention member
US11717289B2 (en) 2020-10-29 2023-08-08 Cilag Gmbh International Surgical instrument comprising an indicator which indicates that an articulation drive is actuatable
US11844518B2 (en) 2020-10-29 2023-12-19 Cilag Gmbh International Method for operating a surgical instrument
US11452526B2 (en) 2020-10-29 2022-09-27 Cilag Gmbh International Surgical instrument comprising a staged voltage regulation start-up system
USD1013170S1 (en) 2020-10-29 2024-01-30 Cilag Gmbh International Surgical instrument assembly
US11517390B2 (en) 2020-10-29 2022-12-06 Cilag Gmbh International Surgical instrument comprising a limited travel switch
US11617577B2 (en) 2020-10-29 2023-04-04 Cilag Gmbh International Surgical instrument comprising a sensor configured to sense whether an articulation drive of the surgical instrument is actuatable
US11779330B2 (en) 2020-10-29 2023-10-10 Cilag Gmbh International Surgical instrument comprising a jaw alignment system
US11534259B2 (en) 2020-10-29 2022-12-27 Cilag Gmbh International Surgical instrument comprising an articulation indicator
US11896217B2 (en) 2020-10-29 2024-02-13 Cilag Gmbh International Surgical instrument comprising an articulation lock
USD980425S1 (en) 2020-10-29 2023-03-07 Cilag Gmbh International Surgical instrument assembly
US11653915B2 (en) 2020-12-02 2023-05-23 Cilag Gmbh International Surgical instruments with sled location detection and adjustment features
US11744581B2 (en) 2020-12-02 2023-09-05 Cilag Gmbh International Powered surgical instruments with multi-phase tissue treatment
US11653920B2 (en) 2020-12-02 2023-05-23 Cilag Gmbh International Powered surgical instruments with communication interfaces through sterile barrier
US11627960B2 (en) 2020-12-02 2023-04-18 Cilag Gmbh International Powered surgical instruments with smart reload with separately attachable exteriorly mounted wiring connections
US11890010B2 (en) 2020-12-02 2024-02-06 Cllag GmbH International Dual-sided reinforced reload for surgical instruments
US11849943B2 (en) 2020-12-02 2023-12-26 Cilag Gmbh International Surgical instrument with cartridge release mechanisms
US11737751B2 (en) 2020-12-02 2023-08-29 Cilag Gmbh International Devices and methods of managing energy dissipated within sterile barriers of surgical instrument housings
US11678882B2 (en) 2020-12-02 2023-06-20 Cilag Gmbh International Surgical instruments with interactive features to remedy incidental sled movements
WO2022132351A1 (en) 2020-12-18 2022-06-23 Gt Metabolic Solutions, Inc. Devices and methods for assisting magnetic compression anastomosis
US11744583B2 (en) 2021-02-26 2023-09-05 Cilag Gmbh International Distal communication array to tune frequency of RF systems
US11812964B2 (en) 2021-02-26 2023-11-14 Cilag Gmbh International Staple cartridge comprising a power management circuit
US11793514B2 (en) 2021-02-26 2023-10-24 Cilag Gmbh International Staple cartridge comprising sensor array which may be embedded in cartridge body
US11730473B2 (en) 2021-02-26 2023-08-22 Cilag Gmbh International Monitoring of manufacturing life-cycle
US11751869B2 (en) 2021-02-26 2023-09-12 Cilag Gmbh International Monitoring of multiple sensors over time to detect moving characteristics of tissue
US11723657B2 (en) 2021-02-26 2023-08-15 Cilag Gmbh International Adjustable communication based on available bandwidth and power capacity
US11749877B2 (en) 2021-02-26 2023-09-05 Cilag Gmbh International Stapling instrument comprising a signal antenna
US11701113B2 (en) 2021-02-26 2023-07-18 Cilag Gmbh International Stapling instrument comprising a separate power antenna and a data transfer antenna
US11696757B2 (en) 2021-02-26 2023-07-11 Cilag Gmbh International Monitoring of internal systems to detect and track cartridge motion status
US11737749B2 (en) 2021-03-22 2023-08-29 Cilag Gmbh International Surgical stapling instrument comprising a retraction system
US11717291B2 (en) 2021-03-22 2023-08-08 Cilag Gmbh International Staple cartridge comprising staples configured to apply different tissue compression
US11759202B2 (en) 2021-03-22 2023-09-19 Cilag Gmbh International Staple cartridge comprising an implantable layer
US11806011B2 (en) 2021-03-22 2023-11-07 Cilag Gmbh International Stapling instrument comprising tissue compression systems
US11826042B2 (en) 2021-03-22 2023-11-28 Cilag Gmbh International Surgical instrument comprising a firing drive including a selectable leverage mechanism
US11723658B2 (en) 2021-03-22 2023-08-15 Cilag Gmbh International Staple cartridge comprising a firing lockout
US11826012B2 (en) 2021-03-22 2023-11-28 Cilag Gmbh International Stapling instrument comprising a pulsed motor-driven firing rack
US11786239B2 (en) 2021-03-24 2023-10-17 Cilag Gmbh International Surgical instrument articulation joint arrangements comprising multiple moving linkage features
US11896219B2 (en) 2021-03-24 2024-02-13 Cilag Gmbh International Mating features between drivers and underside of a cartridge deck
US11849945B2 (en) 2021-03-24 2023-12-26 Cilag Gmbh International Rotary-driven surgical stapling assembly comprising eccentrically driven firing member
US11903582B2 (en) 2021-03-24 2024-02-20 Cilag Gmbh International Leveraging surfaces for cartridge installation
US11832816B2 (en) 2021-03-24 2023-12-05 Cilag Gmbh International Surgical stapling assembly comprising nonplanar staples and planar staples
US11793516B2 (en) 2021-03-24 2023-10-24 Cilag Gmbh International Surgical staple cartridge comprising longitudinal support beam
US11786243B2 (en) 2021-03-24 2023-10-17 Cilag Gmbh International Firing members having flexible portions for adapting to a load during a surgical firing stroke
US11849944B2 (en) 2021-03-24 2023-12-26 Cilag Gmbh International Drivers for fastener cartridge assemblies having rotary drive screws
US11896218B2 (en) 2021-03-24 2024-02-13 Cilag Gmbh International Method of using a powered stapling device
US11744603B2 (en) 2021-03-24 2023-09-05 Cilag Gmbh International Multi-axis pivot joints for surgical instruments and methods for manufacturing same
US11857183B2 (en) 2021-03-24 2024-01-02 Cilag Gmbh International Stapling assembly components having metal substrates and plastic bodies
WO2022225923A1 (en) 2021-04-20 2022-10-27 G.I. Windows, Inc. Systems, devices, and methods for endoscope or laparoscopic magnetic navigation
WO2022232560A1 (en) 2021-04-30 2022-11-03 Gt Metabolic Solutions, Inc. Anastomosis formation with magnetic devices having bioresorbable retention member
US11826047B2 (en) 2021-05-28 2023-11-28 Cilag Gmbh International Stapling instrument comprising jaw mounts
US11877745B2 (en) 2021-10-18 2024-01-23 Cilag Gmbh International Surgical stapling assembly having longitudinally-repeating staple leg clusters

Citations (36)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4547192A (en) 1982-11-12 1985-10-15 Superior Plastic Products Corp. Gastroenteric feeding tube
US4790294A (en) 1987-07-28 1988-12-13 Welch Allyn, Inc. Ball-and-socket bead endoscope steering section
US5327914A (en) 1992-09-02 1994-07-12 Shlain Leonard M Method and devices for use in surgical gastroplastic procedure
US5330503A (en) 1989-05-16 1994-07-19 Inbae Yoon Spiral suture needle for joining tissue
US5345949A (en) 1992-09-02 1994-09-13 Shlain Leonard M Methods for use in surgical gastroplastic procedure
US5382231A (en) 1993-02-02 1995-01-17 Shlain; Leonard M. Method for transesophageal retraction of the stomach
US5437291A (en) 1993-08-26 1995-08-01 Univ Johns Hopkins Method for treating gastrointestinal muscle disorders and other smooth muscle dysfunction
US5549621A (en) 1993-05-14 1996-08-27 Byron C. Sutherland Apparatus and method for performing vertical banded gastroplasty
US5571116A (en) 1994-10-02 1996-11-05 United States Surgical Corporation Non-invasive treatment of gastroesophageal reflux disease
US5582616A (en) 1994-08-05 1996-12-10 Origin Medsystems, Inc. Surgical helical fastener with applicator
US5624381A (en) 1994-08-09 1997-04-29 Kieturakis; Maciej J. Surgical instrument and method for retraction of an anatomic structure defining an interior lumen
US5626588A (en) 1992-04-30 1997-05-06 Lasersurge, Inc. Trocar wound closure device
US5651769A (en) 1995-10-16 1997-07-29 The Beth Israel Hospital Association Method for retrieving pancreatic juice utilizing and endoscopically wire-guided catheter
US5690656A (en) 1995-06-27 1997-11-25 Cook Incorporated Method and apparatus for creating abdominal visceral anastomoses
US5728178A (en) 1993-03-25 1998-03-17 The Ohio State University Guide tube for gastrostomy tube placement
US5749893A (en) 1993-04-30 1998-05-12 United States Surgical Corporation Surgical instrument having an articulated jaw structure and a detachable knife
US5792153A (en) 1994-03-23 1998-08-11 University College London Sewing device
US5827298A (en) 1995-11-17 1998-10-27 Innovasive Devices, Inc. Surgical fastening system and method for using the same
US5868141A (en) 1997-05-14 1999-02-09 Ellias; Yakub A. Endoscopic stomach insert for treating obesity and method for use
US5897534A (en) 1996-08-29 1999-04-27 Team Medical, Llc Body fluids and solids drainage system
US5947983A (en) 1998-03-16 1999-09-07 Boston Scientific Corporation Tissue cutting and stitching device and method
US5964782A (en) 1997-09-18 1999-10-12 Scimed Life Systems, Inc. Closure device and method
US5976161A (en) 1998-01-07 1999-11-02 University Of New Mexico Tissue everting apparatus and method
US6042538A (en) 1998-11-18 2000-03-28 Emory University Device for endoscopic vessel harvesting
US6067991A (en) 1998-08-13 2000-05-30 Forsell; Peter Mechanical food intake restriction device
US6113609A (en) 1998-05-26 2000-09-05 Scimed Life Systems, Inc. Implantable tissue fastener and system for treating gastroesophageal reflux disease
US6159146A (en) 1999-03-12 2000-12-12 El Gazayerli; Mohamed Mounir Method and apparatus for minimally-invasive fundoplication
US6179195B1 (en) 1998-06-19 2001-01-30 Scimed Life Systems, Inc. Method and device for full thickness resectioning of an organ
US6197022B1 (en) 1996-07-30 2001-03-06 James A. Baker Medical instruments and techniques for treatment of gastro-esophageal reflux disease
US6231561B1 (en) 1999-09-20 2001-05-15 Appriva Medical, Inc. Method and apparatus for closing a body lumen
WO2001085034A1 (en) 2000-05-10 2001-11-15 Boston Scientific Limited Devices and related methods for securing a tissue fold
US6328689B1 (en) * 2000-03-23 2001-12-11 Spiration, Inc., Lung constriction apparatus and method
WO2002039880A2 (en) 2000-11-14 2002-05-23 Biomedical Engineering Solutions, Inc. Method and system for internal ligation of tubular structures
US20020072761A1 (en) 1998-05-11 2002-06-13 Surgical Connections, Inc. Surgical stabilizer devices and methods
US20020078967A1 (en) 2000-12-06 2002-06-27 Robert Sixto Methods for the endoluminal treatment of gastroesophageal reflux disease (GERD)
US20020082621A1 (en) 2000-09-22 2002-06-27 Schurr Marc O. Methods and devices for folding and securing tissue

Family Cites Families (368)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US467911A (en) * 1892-02-02 Engraving-block
US2108206A (en) 1937-03-09 1938-02-15 Lillian Pearl Mecker Tenaculum
US2508690A (en) 1948-07-13 1950-05-23 Schmerl Egon Fritz Gastrointestinal tube
US3395710A (en) 1965-06-14 1968-08-06 Robert A. Stratton Gastro-intestinal tube with inflatable weight releasing means
US3372443A (en) 1967-02-16 1968-03-12 Scovill Manufacturing Co Magnetic fastening means
US3986493A (en) 1975-07-28 1976-10-19 Hendren Iii William Hardy Electromagnetic bougienage method
US4063561A (en) 1975-08-25 1977-12-20 The Signal Companies, Inc. Direction control device for endotracheal tube
US4057065A (en) 1976-06-21 1977-11-08 Dow Corning Corporation Percutaneous gastrointestinal tube
US4133315A (en) 1976-12-27 1979-01-09 Berman Edward J Method and apparatus for reducing obesity
US4134405A (en) 1977-01-10 1979-01-16 Smit Julie A Catheter and intestine tube and method of using the same
US4315509A (en) 1977-01-10 1982-02-16 Smit Julie A Insertion and removal catheters and intestinal tubes for restricting absorption
US4198982A (en) 1978-03-31 1980-04-22 Memorial Hospital For Cancer And Allied Diseases Surgical stapling instrument and method
WO1980000007A1 (en) 1978-06-02 1980-01-10 A Rockey Medical sleeve
US4246893A (en) 1978-07-05 1981-01-27 Daniel Berson Inflatable gastric device for treating obesity
US4258705A (en) 1978-09-15 1981-03-31 Coloplast A/S Magnetic system for use in sealing body openings
US4214593A (en) 1978-09-18 1980-07-29 Mallinckrodt, Inc. Esophageal pressure monitoring device
US4343066A (en) 1979-10-15 1982-08-10 Illinois Tool Works Tube clamp
US4311146A (en) 1980-05-08 1982-01-19 Sorenson Research Co., Inc. Detachable balloon catheter apparatus and method
AU548370B2 (en) 1981-10-08 1985-12-05 United States Surgical Corporation Surgical fastener
US4899747A (en) 1981-12-10 1990-02-13 Garren Lloyd R Method and appartus for treating obesity
US4416267A (en) 1981-12-10 1983-11-22 Garren Lloyd R Method and apparatus for treating obesity
JPS58107884A (en) 1981-12-22 1983-06-27 Toyoda Mach Works Ltd Solenoid-control type variable displacement vane pump
US4458681A (en) 1982-06-10 1984-07-10 Hopkins Donald A Stomach clamp for and method of proximal gastric partitioning
US4485805A (en) 1982-08-24 1984-12-04 Gunther Pacific Limited Of Hong Kong Weight loss device and method
US4558699A (en) 1983-01-03 1985-12-17 Bashour Samuel B Method of and apparatus for restricting the passage of food through the stomach
US4607618A (en) 1983-02-23 1986-08-26 Angelchik Jean P Method for treatment of morbid obesity
US4589413A (en) 1983-07-21 1986-05-20 Malyshev Boris N Surgical instrument for resection of hollow organs
US5220928A (en) 1983-08-22 1993-06-22 Stryker Sales Corporation Surgical procedure for joining tissue in an internal body cavity
US4905693A (en) 1983-10-03 1990-03-06 Biagio Ravo Surgical method for using an intraintestinal bypass graft
US4592354A (en) 1983-10-11 1986-06-03 Senmed, Inc. Tissue retention spool for intraluminal anastomotic surgical stapling instrument and methods
GB2147810B (en) 1983-10-13 1987-02-11 Craig Med Prod Ltd Ostomy bag coupling
US4610383A (en) 1983-10-14 1986-09-09 Senmed, Inc. Disposable linear surgical stapler
US4643169A (en) 1983-11-02 1987-02-17 Walter Koss Device for selectively opening and closing tubular organs of the body
US5104399A (en) 1986-12-10 1992-04-14 Endovascular Technologies, Inc. Artificial graft and implantation method
US4671287A (en) 1983-12-29 1987-06-09 Fiddian Green Richard G Apparatus and method for sustaining vitality of organs of the gastrointestinal tract
GB8422863D0 (en) 1984-09-11 1984-10-17 Univ London Sewing machine
US4905695A (en) * 1984-07-19 1990-03-06 Ethicon, Inc. Sterile surgical needle having dark non-reflective surface
US4646722A (en) 1984-12-10 1987-03-03 Opielab, Inc. Protective endoscope sheath and method of installing same
US4648383A (en) 1985-01-11 1987-03-10 Angelchik Jean P Peroral apparatus for morbid obesity treatment
US4723547A (en) 1985-05-07 1988-02-09 C. R. Bard, Inc. Anti-obesity balloon placement system
US4598699A (en) 1985-06-10 1986-07-08 Garren Lloyd R Endoscopic instrument for removing stomach insert
US4592339A (en) 1985-06-12 1986-06-03 Mentor Corporation Gastric banding device
US4696288A (en) 1985-08-14 1987-09-29 Kuzmak Lubomyr I Calibrating apparatus and method of using same for gastric banding surgery
US4694827A (en) 1986-01-14 1987-09-22 Weiner Brian C Inflatable gastric device for treating obesity and method of using the same
US4803985A (en) 1986-02-14 1989-02-14 Hill Carl W Gastroplasty method
US4716900A (en) 1986-05-09 1988-01-05 Pfizer Hospital Products Group, Inc. Intraintestinal bypass graft
US4739758A (en) 1986-05-19 1988-04-26 Criticare Systems, Inc. Apparatus for stomach cavity reduction
IL78883A0 (en) 1986-05-23 1986-09-30 Omikron Scient Ltd Device and method for treating a patient for obesity
US4773393A (en) 1986-07-03 1988-09-27 C. R. Bard, Inc. Hypodermically implantable genitourinary prosthesis
US4744363A (en) 1986-07-07 1988-05-17 Hasson Harrith M Intra-abdominal organ stabilizer, retractor and tissue manipulator
JPS63277063A (en) 1987-05-09 1988-11-15 Olympus Optical Co Ltd Diet balloon
JPS63279854A (en) 1987-05-12 1988-11-16 Olympus Optical Co Ltd Diet balloon extracting apparatus
US5542949A (en) 1987-05-14 1996-08-06 Yoon; Inbae Multifunctional clip applier instrument
JPS63302863A (en) 1987-06-01 1988-12-09 Olympus Optical Co Ltd Endogastric indwelling balloon
US5084061A (en) 1987-09-25 1992-01-28 Gau Fred C Intragastric balloon with improved valve locating means
US4795430A (en) 1988-01-15 1989-01-03 Corpak, Inc. Device for intubation of percutaneous endoscopic ostomy
WO1990000376A1 (en) 1988-07-05 1990-01-25 Cantenys Jose Intragastric balloon
US4925446A (en) 1988-07-06 1990-05-15 Transpharm Group Inc. Removable inflatable intragastrointestinal device for delivering beneficial agents
US4909258A (en) 1988-08-08 1990-03-20 The Beth Israel Hospital Association Internal mammary artery (IMA) catheter
DE3830704A1 (en) 1988-09-09 1990-03-22 Falah Redha MEDICAL INSTRUMENT
US4927428A (en) 1988-10-07 1990-05-22 Ophthalmic Ventures Limited Partnership Surgical suturing system and probe assembly
US4969474A (en) 1988-10-11 1990-11-13 Schwarz Gerald R Incontinence bladder control method and apparatus
US5749914A (en) 1989-01-06 1998-05-12 Advanced Coronary Intervention Catheter for obstructed stent
US5059193A (en) 1989-11-20 1991-10-22 Spine-Tech, Inc. Expandable spinal implant and surgical method
US5026379A (en) 1989-12-05 1991-06-25 Inbae Yoon Multi-functional instruments and stretchable ligating and occluding devices
US5222961A (en) 1989-12-26 1993-06-29 Naomi Nakao Endoscopic stapling device and related staple
US5156609A (en) 1989-12-26 1992-10-20 Nakao Naomi L Endoscopic stapling device and method
US5454365A (en) * 1990-11-05 1995-10-03 Bonutti; Peter M. Mechanically expandable arthroscopic retractors
US5331975A (en) 1990-03-02 1994-07-26 Bonutti Peter M Fluid operated retractors
US5345927A (en) 1990-03-02 1994-09-13 Bonutti Peter M Arthroscopic retractors
US5171233A (en) 1990-04-25 1992-12-15 Microvena Corporation Snare-type probe
US5029580A (en) 1990-07-18 1991-07-09 Ballard Medical Products Medical aspirating apparatus with multi-lumen catheter tube and methods
US5080663A (en) 1990-09-26 1992-01-14 Univerity College London Sewing device
DK1027906T3 (en) 1990-10-09 2005-08-01 Medtronic Inc Device or apparatus for manipulating matter
US5250058A (en) 1991-01-17 1993-10-05 Ethicon, Inc. Absorbable anastomosic fastener means
US5112310A (en) 1991-02-06 1992-05-12 Grobe James L Apparatus and methods for percutaneous endoscopic gastrostomy
US5454787A (en) 1991-02-15 1995-10-03 Lundquist; Ingemar H. Torquable tubular assembly and torquable catheter utilizing the same
JPH0777576B2 (en) 1991-03-27 1995-08-23 了司 服部 Endoscope accessories and endoscope
US5368598A (en) 1991-04-19 1994-11-29 Hasson; Harrith M. Method of manipulating an uterus using a bendable manipulator
US5865728A (en) 1991-05-29 1999-02-02 Origin Medsystems, Inc. Method of using an endoscopic inflatable lifting apparatus to create an anatomic working space
US5370134A (en) 1991-05-29 1994-12-06 Orgin Medsystems, Inc. Method and apparatus for body structure manipulation and dissection
US5226429A (en) 1991-06-20 1993-07-13 Inamed Development Co. Laparoscopic gastric band and method
US5234454A (en) 1991-08-05 1993-08-10 Akron City Hospital Percutaneous intragastric balloon catheter and method for controlling body weight therewith
US5146933A (en) 1991-09-20 1992-09-15 Dow Corning Wright Corporation Implantable prosthetic device and tethered inflation valve for volume
US5197649A (en) 1991-10-29 1993-03-30 The Trustees Of Columbia University In The City Of New York Gastrointestinal endoscoptic stapler
US5325860A (en) 1991-11-08 1994-07-05 Mayo Foundation For Medical Education And Research Ultrasonic and interventional catheter and method
US5433721A (en) 1992-01-17 1995-07-18 Ethicon, Inc. Endoscopic instrument having a torsionally stiff drive shaft for applying fasteners to tissue
US5284128A (en) 1992-01-24 1994-02-08 Applied Medical Resources Corporation Surgical manipulator
CA2088883A1 (en) 1992-02-13 1993-08-14 David T. Green Endoscopic ligating instrument
US5259399A (en) 1992-03-02 1993-11-09 Alan Brown Device and method of causing weight loss using removable variable volume intragastric bladder
US5355897A (en) 1992-04-16 1994-10-18 Ethicon, Inc. Method of performing a pyloroplasty/pylorectomy using a stapler having a shield
US5301658A (en) 1992-04-27 1994-04-12 Loma Linda University Medical Center Membrane endoscopic retractor
DE69333161T2 (en) * 1992-05-08 2004-06-03 Schneider (Usa) Inc., Plymouth Stent for the esophagus
US5817102A (en) 1992-05-08 1998-10-06 Schneider (Usa) Inc. Apparatus for delivering and deploying a stent
US5906625A (en) 1992-06-04 1999-05-25 Olympus Optical Co., Ltd. Tissue-fixing surgical instrument, tissue-fixing device, and method of fixing tissue
US5658300A (en) 1992-06-04 1997-08-19 Olympus Optical Co., Ltd. Tissue fixing surgical instrument, tissue-fixing device, and method of fixing tissues
US5797931A (en) 1992-06-04 1998-08-25 Olympus Optical Co., Ltd. Tissue-fixing surgical instrument, tissue-fixing device, and method of fixing tissues
US5246456A (en) 1992-06-08 1993-09-21 Wilkinson Lawrence H Fenestrated gastric pouch
US5254126A (en) 1992-06-24 1993-10-19 Ethicon, Inc. Endoscopic suture punch
US5263629A (en) 1992-06-29 1993-11-23 Ethicon, Inc. Method and apparatus for achieving hemostasis along a staple line
US5330486A (en) 1992-07-29 1994-07-19 Wilk Peter J Laparoscopic or endoscopic anastomosis technique and associated instruments
US5248302A (en) 1992-08-05 1993-09-28 Biosearch Medical Products Inc. Percutaneous obturatable internal anchoring device
US5261920A (en) 1992-08-21 1993-11-16 Ethicon, Inc. Anvil bushing for circular stapler
US5297536A (en) 1992-08-25 1994-03-29 Wilk Peter J Method for use in intra-abdominal surgery
US5458131A (en) 1992-08-25 1995-10-17 Wilk; Peter J. Method for use in intra-abdominal surgery
US5578044A (en) 1992-09-04 1996-11-26 Laurus Medical Corporation Endoscopic suture system
US5364408A (en) 1992-09-04 1994-11-15 Laurus Medical Corporation Endoscopic suture system
GB9218754D0 (en) * 1992-09-04 1992-10-21 Univ London Device for use in securing a thread
US5306300A (en) 1992-09-22 1994-04-26 Berry H Lee Tubular digestive screen
US5601224A (en) 1992-10-09 1997-02-11 Ethicon, Inc. Surgical instrument
US6051003A (en) 1992-10-09 2000-04-18 Boston Scientific Corporation Combined multiple ligating band dispenser and sclerotherapy needle instrument
US5309927A (en) 1992-10-22 1994-05-10 Ethicon, Inc. Circular stapler tissue retention spring method
US5259366A (en) 1992-11-03 1993-11-09 Boris Reydel Method of using a catheter-sleeve assembly for an endoscope
US5403312A (en) 1993-07-22 1995-04-04 Ethicon, Inc. Electrosurgical hemostatic device
US5403326A (en) 1993-02-01 1995-04-04 The Regents Of The University Of California Method for performing a gastric wrap of the esophagus for use in the treatment of esophageal reflux
US5346501A (en) 1993-02-05 1994-09-13 Ethicon, Inc. Laparoscopic absorbable anastomosic fastener and means for applying
US5449368A (en) 1993-02-18 1995-09-12 Kuzmak; Lubomyr I. Laparoscopic adjustable gastric banding device and method for implantation and removal thereof
US5462559A (en) 1993-02-23 1995-10-31 Ahmed; Munir Endoscopic ligating instrument
KR960700656A (en) 1993-02-22 1996-02-24 알렌 제이. 스피겔 Laparoscopic dissection tension retractor device and method (A LAPAROSCOPIC DISSECTION TENSION RETRACTOR DEVICE AND METHOD)
JPH06281280A (en) 1993-03-29 1994-10-07 Toshiba Corp Air conditioner
US5334210A (en) 1993-04-09 1994-08-02 Cook Incorporated Vascular occlusion assembly
US5467911A (en) 1993-04-27 1995-11-21 Olympus Optical Co., Ltd. Surgical device for stapling and fastening body tissues
US5601604A (en) * 1993-05-27 1997-02-11 Inamed Development Co. Universal gastric band
GR940100335A (en) * 1993-07-22 1996-05-22 Ethicon Inc. Electrosurgical device for placing staples.
US5376095A (en) 1993-11-04 1994-12-27 Ethicon Endo-Surgery Endoscopic multi-fire flat stapler with low profile
US5527322A (en) * 1993-11-08 1996-06-18 Perclose, Inc. Device and method for suturing of internal puncture sites
US5503635A (en) 1993-11-12 1996-04-02 United States Surgical Corporation Apparatus and method for performing compressional anastomoses
WO1995013110A1 (en) 1993-11-12 1995-05-18 Micro Interventional Systems Small diameter, high torque catheter
US5465894A (en) 1993-12-06 1995-11-14 Ethicon, Inc. Surgical stapling instrument with articulated stapling head assembly on rotatable and flexible support shaft
US5452837A (en) 1994-01-21 1995-09-26 Ethicon Endo-Surgery, Inc. Surgical stapler with tissue gripping ridge
GB9405791D0 (en) * 1994-03-23 1994-05-11 Univ London Device for use in cutting threads
US5860581A (en) * 1994-03-24 1999-01-19 United States Surgical Corporation Anvil for circular stapler
US5489058A (en) 1994-05-02 1996-02-06 Minnesota Mining And Manufacturing Company Surgical stapler with mechanisms for reducing the firing force
US5558665A (en) 1994-06-24 1996-09-24 Archimedes Surgical, Inc. Surgical instrument and method for intraluminal retraction of an anatomic structure
US5551622A (en) 1994-07-13 1996-09-03 Yoon; Inbae Surgical stapler
US5411408A (en) * 1994-08-19 1995-05-02 Molex Incorporated Electrical connector for printed circuit boards
CA2146508C (en) 1994-08-25 2006-11-14 Robert H. Schnut Anvil for circular stapler
US6015429A (en) 1994-09-08 2000-01-18 Gore Enterprise Holdings, Inc. Procedures for introducing stents and stent-grafts
US5555898A (en) 1994-09-26 1996-09-17 Applied Medical Research, Inc. Gastric access device
US5868760A (en) * 1994-12-07 1999-02-09 Mcguckin, Jr.; James F. Method and apparatus for endolumenally resectioning tissue
US6030392A (en) * 1995-01-18 2000-02-29 Motorola, Inc. Connector for hollow anatomical structures and methods of use
WO1996024292A1 (en) 1995-02-07 1996-08-15 C.R. Bard, Inc. Telescoping serial elastic band ligator
US5607441A (en) * 1995-03-24 1997-03-04 Ethicon Endo-Surgery, Inc. Surgical dissector
CH688174A5 (en) * 1995-03-28 1997-06-13 Norman Godin Prosthesis to oppose the gastric reflux into the esophagus.
US6132438A (en) 1995-06-07 2000-10-17 Ep Technologies, Inc. Devices for installing stasis reducing means in body tissue
US5810855A (en) 1995-07-21 1998-09-22 Gore Enterprise Holdings, Inc. Endoscopic device and method for reinforcing surgical staples
US5839639A (en) 1995-08-17 1998-11-24 Lasersurge, Inc. Collapsible anvil assembly and applicator instrument
US5662667A (en) 1995-09-19 1997-09-02 Ethicon Endo-Surgery, Inc. Surgical clamping mechanism
US5836311A (en) 1995-09-20 1998-11-17 Medtronic, Inc. Method and apparatus for temporarily immobilizing a local area of tissue
US5722990A (en) * 1995-11-08 1998-03-03 Sugar Surgical Technologies, Inc. Tissue grasping device
US5782844A (en) * 1996-03-05 1998-07-21 Inbae Yoon Suture spring device applicator
US5810851A (en) * 1996-03-05 1998-09-22 Yoon; Inbae Suture spring device
US5792044A (en) * 1996-03-22 1998-08-11 Danek Medical, Inc. Devices and methods for percutaneous surgery
US5766216A (en) * 1996-05-30 1998-06-16 Gangal; Hanamraddi T. Band applicator for appendicular and meso-appendicular stumps
US6119913A (en) 1996-06-14 2000-09-19 Boston Scientific Corporation Endoscopic stapler
US5776054A (en) 1996-08-07 1998-07-07 Bobra; Dilip Apparatus for retracting tissue
US5904147A (en) 1996-08-16 1999-05-18 University Of Massachusetts Intravascular catheter and method of controlling hemorrhage during minimally invasive surgery
US5935107A (en) 1996-10-07 1999-08-10 Applied Medical Resources Corporation Apparatus and method for surgically accessing a body cavity
US6120432A (en) * 1997-04-23 2000-09-19 Vascular Science Inc. Medical grafting methods and apparatus
US5972001A (en) * 1996-11-25 1999-10-26 Yoon; Inbae Method of ligating anatomical tissue with a suture spring device
US5961440A (en) 1997-01-02 1999-10-05 Myocor, Inc. Heart wall tension reduction apparatus and method
US5879371A (en) * 1997-01-09 1999-03-09 Elective Vascular Interventions, Inc. Ferruled loop surgical fasteners, instruments, and methods for minimally invasive vascular and endoscopic surgery
EP1006886B1 (en) 1997-02-13 2003-07-09 Boston Scientific Limited Dilator for minimally invasive pelvic surgery
IL120636A0 (en) * 1997-04-10 1997-08-14 Technion Res & Dev Foundation Kit for sternum fixation in chest surgery
US5910105A (en) * 1997-04-14 1999-06-08 C.R. Bard, Inc. Control handle for an endoscope
US5921993A (en) * 1997-05-01 1999-07-13 Yoon; Inbae Methods of endoscopic tubal ligation
US5938669A (en) 1997-05-07 1999-08-17 Klasamed S.A. Adjustable gastric banding device for contracting a patient's stomach
JP3902290B2 (en) * 1997-06-19 2007-04-04 ペンタックス株式会社 Endoscope ligature
US6071292A (en) 1997-06-28 2000-06-06 Transvascular, Inc. Transluminal methods and devices for closing, forming attachments to, and/or forming anastomotic junctions in, luminal anatomical structures
US6159234A (en) 1997-08-01 2000-12-12 Peter M. Bonutti Method and apparatus for securing a suture
US5820584A (en) 1997-08-28 1998-10-13 Crabb; Jerry A. Duodenal insert and method of use
FR2768324B1 (en) 1997-09-12 1999-12-10 Jacques Seguin SURGICAL INSTRUMENT FOR PERCUTANEOUSLY FIXING TWO AREAS OF SOFT TISSUE, NORMALLY MUTUALLY REMOTE, TO ONE ANOTHER
US5887594A (en) * 1997-09-22 1999-03-30 Beth Israel Deaconess Medical Center Inc. Methods and devices for gastroesophageal reflux reduction
AU755390B2 (en) 1997-10-02 2002-12-12 Tyco Group S.A.R.L. Transanal anastomosis ring insertion device
US6186985B1 (en) * 1997-10-03 2001-02-13 Boston Scientific Corporation Gastro-intestinal tube with dissolvable support bolster
US6030364A (en) * 1997-10-03 2000-02-29 Boston Scientific Corporation Apparatus and method for percutaneous placement of gastro-intestinal tubes
US5993464A (en) 1998-01-23 1999-11-30 Ethicon Endo-Surgery, Inc. Surgical stapling instrument
US6086600A (en) * 1997-11-03 2000-07-11 Symbiosis Corporation Flexible endoscopic surgical instrument for invagination and fundoplication
US6551328B2 (en) 1997-11-03 2003-04-22 Symbiosis Corporation Surgical instrument for invagination and fundoplication
US5993473A (en) 1997-11-19 1999-11-30 Chan; Yung C. Expandable body device for the gastric cavity and method
US6254642B1 (en) 1997-12-09 2001-07-03 Thomas V. Taylor Perorally insertable gastroesophageal anti-reflux valve prosthesis and tool for implantation thereof
US6120513A (en) * 1998-01-09 2000-09-19 Bailey; Robert W. Laparoscopic surgery instrumentation and method of its use
US6352543B1 (en) * 2000-04-29 2002-03-05 Ventrica, Inc. Methods for forming anastomoses using magnetic force
US7468060B2 (en) 1998-02-19 2008-12-23 Respiratory Diagnostic, Inc. Systems and methods for treating obesity and other gastrointestinal conditions
US6159195A (en) 1998-02-19 2000-12-12 Percusurge, Inc. Exchange catheter and method of use
US6692485B1 (en) * 1998-02-24 2004-02-17 Endovia Medical, Inc. Articulated apparatus for telemanipulator system
US6554844B2 (en) 1998-02-24 2003-04-29 Endovia Medical, Inc. Surgical instrument
US6279809B1 (en) 1998-03-10 2001-08-28 Enrico Nicolo Circular stapler for side to end, side to side and end to side anastomosis
GB9808426D0 (en) 1998-04-21 1998-06-17 Univ London Device with means for propelling it along a passage
US5910149A (en) 1998-04-29 1999-06-08 Kuzmak; Lubomyr I. Non-slipping gastric band
US5972002A (en) * 1998-06-02 1999-10-26 Cabot Technology Corporation Apparatus and method for surgical ligation
US6802841B2 (en) * 1998-06-04 2004-10-12 Curon Medical, Inc. Systems and methods for applying a selected treatment agent into contact with tissue to treat sphincter dysfunction
US6224614B1 (en) 1998-06-17 2001-05-01 Inbae Yoon Suturing instrument with angled needle holder and method for use thereof
US6601749B2 (en) 1998-06-19 2003-08-05 Scimed Life Systems, Inc. Multi fire full thickness resectioning device
US6585144B2 (en) * 1998-06-19 2003-07-01 Acimed Life Systems, Inc. Integrated surgical staple retainer for a full thickness resectioning device
US6830546B1 (en) 1998-06-22 2004-12-14 Origin Medsystems, Inc. Device and method for remote vessel ligation
US6044847A (en) * 1998-06-23 2000-04-04 Surx, Inc. Tuck and fold fascia shortening for incontinence
US6165183A (en) * 1998-07-15 2000-12-26 St. Jude Medical, Inc. Mitral and tricuspid valve repair
WO2000007640A2 (en) 1998-07-22 2000-02-17 Angiolink Corporation Vascular suction cannula, dilator and surgical stapler
US6334865B1 (en) * 1998-08-04 2002-01-01 Fusion Medical Technologies, Inc. Percutaneous tissue track closure assembly and method
US6460543B1 (en) 1998-08-13 2002-10-08 Obtech Medical Ag Non-injection port food intake restriction device
US6746489B2 (en) 1998-08-31 2004-06-08 Wilson-Cook Medical Incorporated Prosthesis having a sleeve valve
WO2000032137A1 (en) 1998-08-31 2000-06-08 Wilson-Cook Medical Inc. Anti-reflux esophageal prosthesis
JP2002529188A (en) 1998-11-18 2002-09-10 ジェネラル サージカル イノヴェイションズ インコーポレイテッド Spiral fasteners and surgical applicators
US6083241A (en) 1998-11-23 2000-07-04 Ethicon Endo-Surgery, Inc. Method of use of a circular stapler for hemorrhoidal procedure
US6238335B1 (en) 1998-12-11 2001-05-29 Enteric Medical Technologies, Inc. Method for treating gastroesophageal reflux disease and apparatus for use therewith
US6349307B1 (en) 1998-12-28 2002-02-19 U.S. Philips Corporation Cooperative topical servers with automatic prefiltering and routing
US6322538B1 (en) 1999-02-18 2001-11-27 Scimed Life Systems, Inc. Gastro-intestinal tube placement device
US6293923B1 (en) 1999-03-15 2001-09-25 Innoventions, Inc. Intravesicular balloon
US6179022B1 (en) * 1999-03-22 2001-01-30 Jinghua Schneider Molded one-piece weighing funnel
US6338345B1 (en) * 1999-04-07 2002-01-15 Endonetics, Inc. Submucosal prosthesis delivery device
JP4657456B2 (en) 1999-04-09 2011-03-23 イバルブ・インコーポレーテッド Method and apparatus for heart valve repair
US6074343A (en) 1999-04-16 2000-06-13 Nathanson; Michael Surgical tissue retractor
US6821285B2 (en) * 1999-06-22 2004-11-23 Ndo Surgical, Inc. Tissue reconfiguration
US6663639B1 (en) * 1999-06-22 2003-12-16 Ndo Surgical, Inc. Methods and devices for tissue reconfiguration
US6506196B1 (en) * 1999-06-22 2003-01-14 Ndo Surgical, Inc. Device and method for correction of a painful body defect
US6494888B1 (en) * 1999-06-22 2002-12-17 Ndo Surgical, Inc. Tissue reconfiguration
US6835200B2 (en) * 1999-06-22 2004-12-28 Ndo Surgical. Inc. Method and devices for tissue reconfiguration
US7846180B2 (en) 1999-06-22 2010-12-07 Ethicon Endo-Surgery, Inc. Tissue fixation devices and methods of fixing tissue
US20040122456A1 (en) 2002-12-11 2004-06-24 Saadat Vahid C. Methods and apparatus for gastric reduction
US7416554B2 (en) 2002-12-11 2008-08-26 Usgi Medical Inc Apparatus and methods for forming and securing gastrointestinal tissue folds
US7744613B2 (en) * 1999-06-25 2010-06-29 Usgi Medical, Inc. Apparatus and methods for forming and securing gastrointestinal tissue folds
US7160312B2 (en) * 1999-06-25 2007-01-09 Usgi Medical, Inc. Implantable artificial partition and methods of use
US7637905B2 (en) 2003-01-15 2009-12-29 Usgi Medical, Inc. Endoluminal tool deployment system
US6626899B2 (en) * 1999-06-25 2003-09-30 Nidus Medical, Llc Apparatus and methods for treating tissue
US6991643B2 (en) * 2000-12-20 2006-01-31 Usgi Medical Inc. Multi-barbed device for retaining tissue in apposition and methods of use
US7618426B2 (en) 2002-12-11 2009-11-17 Usgi Medical, Inc. Apparatus and methods for forming gastrointestinal tissue approximations
JP4108882B2 (en) 1999-08-04 2008-06-25 オリンパス株式会社 Endoscope wall fixture
US6358197B1 (en) * 1999-08-13 2002-03-19 Enteric Medical Technologies, Inc. Apparatus for forming implants in gastrointestinal tract and kit for use therewith
US6610043B1 (en) * 1999-08-23 2003-08-26 Bistech, Inc. Tissue volume reduction
US6312447B1 (en) 1999-10-13 2001-11-06 The General Hospital Corporation Devices and methods for percutaneous mitral valve repair
US6626930B1 (en) 1999-10-21 2003-09-30 Edwards Lifesciences Corporation Minimally invasive mitral valve repair method and apparatus
US6387104B1 (en) 1999-11-12 2002-05-14 Scimed Life Systems, Inc. Method and apparatus for endoscopic repair of the lower esophageal sphincter
US6551310B1 (en) 1999-11-16 2003-04-22 Robert A. Ganz System and method of treating abnormal tissue in the human esophagus
US6689062B1 (en) * 1999-11-23 2004-02-10 Microaccess Medical Systems, Inc. Method and apparatus for transesophageal cardiovascular procedures
US20030208212A1 (en) * 1999-12-07 2003-11-06 Valerio Cigaina Removable gastric band
US6613026B1 (en) 1999-12-08 2003-09-02 Scimed Life Systems, Inc. Lateral needle-less injection apparatus and method
EP1108400A1 (en) 1999-12-13 2001-06-20 Biomedix S.A. Removable fixation apparatus for a prosthesis in a body vessel
US6475136B1 (en) 2000-02-14 2002-11-05 Obtech Medical Ag Hydraulic heartburn and reflux treatment
MXPA00001922A (en) 2000-02-24 2002-03-08 De Hayos Garza Andres Percutaneous intra-gastric balloon catheter for obesity treatment.
US6273897B1 (en) 2000-02-29 2001-08-14 Ethicon, Inc. Surgical bettress and surgical stapling apparatus
JP2004514462A (en) * 2000-03-03 2004-05-20 シー・アール・バード・インク Tissue adhesion device for endoscope with multiple suction ports
CA2718633C (en) 2000-03-06 2013-01-08 Tyco Healthcare Group Lp Apparatus and method for performing a bypass procedure in a digestive system
EP1452125A3 (en) 2000-03-16 2004-10-13 Medigus Ltd Fundoplication apparatus and method
FR2808674B1 (en) * 2000-05-12 2002-08-02 Cie Euro Etude Rech Paroscopie GASTROPLASTY RING WITH GRIPPED LEGS
US6663598B1 (en) 2000-05-17 2003-12-16 Scimed Life Systems, Inc. Fluid seal for endoscope
US7220266B2 (en) 2000-05-19 2007-05-22 C. R. Bard, Inc. Tissue capturing and suturing device and method
US6540789B1 (en) 2000-06-15 2003-04-01 Scimed Life Systems, Inc. Method for treating morbid obesity
RS50397B (en) 2000-07-28 2009-12-31 F. Hoffmann-La Roche Ag., Pharmaceutical composition
WO2002013854A1 (en) * 2000-08-11 2002-02-21 Temple University Of The Commonwealth System Of Higher Education Obesity controlling method
US7737109B2 (en) * 2000-08-11 2010-06-15 Temple University Of The Commonwealth System Of Higher Education Obesity controlling method
US6572629B2 (en) * 2000-08-17 2003-06-03 Johns Hopkins University Gastric reduction endoscopy
US6432040B1 (en) 2000-09-14 2002-08-13 Nizam N. Meah Implantable esophageal sphincter apparatus for gastroesophageal reflux disease and method
US7033373B2 (en) 2000-11-03 2006-04-25 Satiety, Inc. Method and device for use in minimally invasive placement of space-occupying intragastric devices
US6579301B1 (en) 2000-11-17 2003-06-17 Syntheon, Llc Intragastric balloon device adapted to be repeatedly varied in volume without external assistance
US6398795B1 (en) * 2000-11-30 2002-06-04 Scimed Life Systems, Inc. Stapling and cutting in resectioning for full thickness resection devices
US6799203B2 (en) 2000-12-29 2004-09-28 Nokia Mobile Phones Ltd. WTA based over the air management (OTAM) method and apparatus
US6837848B2 (en) * 2003-01-15 2005-01-04 Medtronic, Inc. Methods and apparatus for accessing and stabilizing an area of the heart
US6786898B2 (en) 2003-01-15 2004-09-07 Medtronic, Inc. Methods and tools for accessing an anatomic space
US6754536B2 (en) 2001-01-31 2004-06-22 Medtronic, Inc Implantable medical device affixed internally within the gastrointestinal tract
JP4202138B2 (en) * 2001-01-31 2008-12-24 レックス メディカル インコーポレイテッド Apparatus and method for stapling and ablating gastroesophageal tissue
ES2174749B1 (en) 2001-02-12 2004-08-16 Luis Miguel Molina Trigueros GASTRIC CLAMP FOR THE CONDUCT OF VERTICAL GASTROPLASTIA BANDEADA AND BY-PASS GASTRIC TO MINOR CURVING.
WO2002071951A1 (en) 2001-03-09 2002-09-19 Garza Alvarez Jose Rafael Intragastric balloon assembly
US7020531B1 (en) * 2001-05-01 2006-03-28 Intrapace, Inc. Gastric device and suction assisted method for implanting a device on a stomach wall
US20050143760A1 (en) 2001-05-01 2005-06-30 Imran Mir A. Endoscopic gastric constriction device
US6535764B2 (en) * 2001-05-01 2003-03-18 Intrapace, Inc. Gastric treatment and diagnosis device and method
JP4255286B2 (en) 2001-05-17 2009-04-15 ウィルソン−クック メディカル インコーポレイテッド Intragastric device for treating obesity
US6916332B2 (en) * 2001-05-23 2005-07-12 Scimed Life Systems, Inc. Endoluminal fundoplication device and related method for installing tissue fastener
US7083629B2 (en) 2001-05-30 2006-08-01 Satiety, Inc. Overtube apparatus for insertion into a body
US6558400B2 (en) 2001-05-30 2003-05-06 Satiety, Inc. Obesity treatment tools and methods
WO2003007796A2 (en) 2001-07-18 2003-01-30 Ndo Surgical, Inc. Methods and devices for tissue reconfiguration
US6632227B2 (en) 2001-08-24 2003-10-14 Scimed Life Systems, Inc. Endoscopic resection devices
US6845776B2 (en) 2001-08-27 2005-01-25 Richard S. Stack Satiation devices and methods
US6675809B2 (en) * 2001-08-27 2004-01-13 Richard S. Stack Satiation devices and methods
US6740121B2 (en) 2001-11-09 2004-05-25 Boston Scientific Corporation Intragastric stent for duodenum bypass
US6755869B2 (en) 2001-11-09 2004-06-29 Boston Scientific Corporation Intragastric prosthesis for the treatment of morbid obesity
JP2005512667A (en) * 2001-12-20 2005-05-12 レックス メディカル リミテッド パートナーシップ Device for treating gastroesophageal reflux disease
US7530985B2 (en) 2002-01-30 2009-05-12 Olympus Corporation Endoscopic suturing system
US6736822B2 (en) * 2002-02-20 2004-05-18 Mcclellan Scott B. Device and method for internal ligation of tubular structures
US6733512B2 (en) 2002-03-07 2004-05-11 Mcghan Jim J. Self-deflating intragastric balloon
US6921408B2 (en) 2002-03-12 2005-07-26 Lsi Solutions, Inc. Apparatus for sewing tissue and method of use
JP4351458B2 (en) 2002-03-18 2009-10-28 オリンパス株式会社 Endoscope insertion system
US6755849B1 (en) 2002-03-28 2004-06-29 Board Of Regents, The University Of Texas System Method for delivering energy to tissue and apparatus
US7146984B2 (en) 2002-04-08 2006-12-12 Synecor, Llc Method and apparatus for modifying the exit orifice of a satiation pouch
JP4426852B2 (en) 2002-04-08 2010-03-03 シネコー・エルエルシー Saturation device and method
CA2479765C (en) 2002-04-15 2009-01-27 Cook Biotech Incorporated Apparatus and method for producing a reinforced surgical staple line
JP4142336B2 (en) * 2002-05-02 2008-09-03 富士フイルム株式会社 Silver halide photographic material
JP2005524485A (en) 2002-05-09 2005-08-18 ディー.イーガン トマス Gastric bypass prosthesis
US6790214B2 (en) 2002-05-17 2004-09-14 Esophyx, Inc. Transoral endoscopic gastroesophageal flap valve restoration device, assembly, system and method
DE10223348C1 (en) 2002-05-25 2003-12-11 Siemens Ag Method and device for generating a total stack of flat mail items
US6676605B2 (en) 2002-06-07 2004-01-13 Diagnostic Ultrasound Bladder wall thickness measurement system and methods
US20050194038A1 (en) 2002-06-13 2005-09-08 Christoph Brabec Electrodes for optoelectronic components and the use thereof
JP4437076B2 (en) 2002-06-13 2010-03-24 ユーエスジーアイ メディカル, インコーポレイテッド A method of advancing an instrument through a shape-fixable device and an unsupported anatomical structure.
US6783491B2 (en) 2002-06-13 2004-08-31 Vahid Saadat Shape lockable apparatus and method for advancing an instrument through unsupported anatomy
WO2004003189A2 (en) 2002-06-26 2004-01-08 Bayer Healthcare Ag Regulation of human phospholipase c-like protein
US6773440B2 (en) * 2002-07-02 2004-08-10 Satiety, Inc. Method and device for use in tissue approximation and fixation
JP4373146B2 (en) 2002-07-11 2009-11-25 オリンパス株式会社 Endoscopic suturing device
AU2003252142A1 (en) 2002-07-24 2004-02-09 Leonard Aubrey Method for securing an inoculating pellet to a filter and inoculation filter thus obtained
US6746460B2 (en) * 2002-08-07 2004-06-08 Satiety, Inc. Intra-gastric fastening devices
US7211114B2 (en) * 2002-08-26 2007-05-01 The Trustees Of Columbia University In The City Of New York Endoscopic gastric bypass
US20040044364A1 (en) 2002-08-29 2004-03-04 Devries Robert Tissue fasteners and related deployment systems and methods
MXPA05002284A (en) 2002-08-29 2006-02-10 Mitralsolutions Inc Implantable devices for controlling the internal circumference of an anatomic orifice or lumen.
US7083630B2 (en) 2002-08-29 2006-08-01 Scimed Life Systems, Inc. Devices and methods for fastening tissue layers
US7214233B2 (en) * 2002-08-30 2007-05-08 Satiety, Inc. Methods and devices for maintaining a space occupying device in a relatively fixed location within a stomach
US6981978B2 (en) * 2002-08-30 2006-01-03 Satiety, Inc. Methods and devices for maintaining a space occupying device in a relatively fixed location within a stomach
US7033384B2 (en) 2002-08-30 2006-04-25 Satiety, Inc. Stented anchoring of gastric space-occupying devices
ATE538727T1 (en) * 2002-09-09 2012-01-15 Brian Kelleher DEVICE FOR ENDOLUMINAL THERAPY
US7033378B2 (en) * 2002-09-20 2006-04-25 Id, Llc Surgical fastener, particularly for the endoluminal treatment of gastroesophageal reflux disease (GERD)
US7731655B2 (en) 2002-09-20 2010-06-08 Id, Llc Tissue retractor and method for using the retractor
US6966919B2 (en) * 2002-09-20 2005-11-22 Id, Llc Instrument for applying a surgical fastener particularly for the transoral treatment of gastroesophageal reflux disease (GERD)
US7678122B2 (en) * 2002-09-20 2010-03-16 Id, Llc Method of performing a treatment for gastroesophagheal reflux disease (GERD)
US7220237B2 (en) 2002-10-23 2007-05-22 Satiety, Inc. Method and device for use in endoscopic organ procedures
US7229428B2 (en) 2002-10-23 2007-06-12 Satiety, Inc. Method and device for use in endoscopic organ procedures
US7794447B2 (en) * 2002-11-01 2010-09-14 Valentx, Inc. Gastrointestinal sleeve device and methods for treatment of morbid obesity
US9060844B2 (en) 2002-11-01 2015-06-23 Valentx, Inc. Apparatus and methods for treatment of morbid obesity
US7037344B2 (en) 2002-11-01 2006-05-02 Valentx, Inc. Apparatus and methods for treatment of morbid obesity
US6656194B1 (en) 2002-11-05 2003-12-02 Satiety, Inc. Magnetic anchoring devices
US20040133147A1 (en) 2002-11-06 2004-07-08 Woo Sang Hoon Intestinal bypass device to treat obesity
AU2003293191B2 (en) 2002-11-29 2008-08-07 William E. Cohn Apparatus and method for manipulating tissue
US6962564B2 (en) 2002-12-02 2005-11-08 Hickle Randall S Systems and methods for providing gastrointestinal pain management
US7025791B2 (en) 2002-12-02 2006-04-11 Gi Dynamics, Inc. Bariatric sleeve
CA2508719A1 (en) 2002-12-05 2004-07-22 Id, Llc Tissue retractor and method for using the retractor
US7942884B2 (en) 2002-12-11 2011-05-17 Usgi Medical, Inc. Methods for reduction of a gastric lumen
US7942898B2 (en) 2002-12-11 2011-05-17 Usgi Medical, Inc. Delivery systems and methods for gastric reduction
US7037343B2 (en) 2002-12-23 2006-05-02 Python, Inc. Stomach prosthesis
US20040181242A1 (en) 2003-03-12 2004-09-16 Stack Richard S. Articulated suturing system
US20040194157A1 (en) 2003-03-24 2004-09-30 Meguid Michael M. Animal with surgically modified gastrointestinal tract and method for study of weight reduction
DE602004019505D1 (en) 2003-03-28 2009-04-02 Gi Dynamics Inc DEVICES AGAINST GRAVITY
US20040249362A1 (en) 2003-03-28 2004-12-09 Gi Dynamics, Inc. Enzyme sleeve
US7175638B2 (en) 2003-04-16 2007-02-13 Satiety, Inc. Method and devices for modifying the function of a body organ
US20040215180A1 (en) 2003-04-25 2004-10-28 Medtronic, Inc. Ablation of stomach lining to treat obesity
CN1822794B (en) 2003-05-16 2010-05-26 C.R.巴德有限公司 Single intubation, multi-stitch endoscopic suturing system
US9498366B2 (en) * 2003-07-28 2016-11-22 Baronova, Inc. Devices and methods for pyloric anchoring
US20050038415A1 (en) * 2003-08-06 2005-02-17 Rohr William L. Method and apparatus for the treatment of obesity
EP1671590A1 (en) 2003-09-08 2006-06-21 José Rafael Garza Alvarez Intragastric balloon assembly
US20050247320A1 (en) 2003-10-10 2005-11-10 Stack Richard S Devices and methods for retaining a gastro-esophageal implant
US7097650B2 (en) 2003-10-14 2006-08-29 Satiety, Inc. System for tissue approximation and fixation
US7914543B2 (en) 2003-10-14 2011-03-29 Satiety, Inc. Single fold device for tissue fixation
US20050080444A1 (en) 2003-10-14 2005-04-14 Kraemer Stefan J.M. Transesophageal gastric reduction device, system and method
US20050085787A1 (en) 2003-10-17 2005-04-21 Laufer Michael D. Minimally invasive gastrointestinal bypass
US7758493B2 (en) 2003-10-23 2010-07-20 Proxy Biomedical Limited Gastric constriction device
DE10350898B4 (en) 2003-10-31 2005-11-10 Siemens Ag Patient positioning device and computer tomograph
US7736372B2 (en) 2003-11-13 2010-06-15 Usgi Medical, Inc. Apparatus and methods for endoscopic suturing
DE10353268B3 (en) 2003-11-14 2005-07-28 Infineon Technologies Ag Parallel multi-thread processor with divided contexts has thread control unit that generates multiplexed control signals for switching standard processor body units to context memories to minimize multi-thread processor blocking probability
DE10354557B4 (en) 2003-11-21 2007-11-29 Infineon Technologies Ag Method and apparatus for predicting noise contained in a received signal and a digital receiver
DE10354833A1 (en) 2003-11-24 2005-06-23 Liedtke, Rainer K., Dr. Dermal diagnostic patch systems with active transponders
EP1535655B1 (en) 2003-11-25 2010-07-14 Mann+Hummel Gmbh Fluid filter with release of additives
JP4669480B2 (en) 2003-12-09 2011-04-13 ジーアイ・ダイナミックス・インコーポレーテッド Intestinal sleeve
WO2005058239A2 (en) 2003-12-12 2005-06-30 Usgi Medical Inc. Apparatus and methods for forming and securing gastrointestinal tissue folds
US7087011B2 (en) 2003-12-30 2006-08-08 Gi View Ltd. Gastrointestinal system with traction member
US20050177176A1 (en) 2004-02-05 2005-08-11 Craig Gerbi Single-fold system for tissue approximation and fixation
EP1713402B1 (en) 2004-02-13 2018-07-04 Ethicon Endo-Surgery, Inc. Device for reducing stomach volume
US7708684B2 (en) 2004-02-27 2010-05-04 Satiety, Inc. Methods and devices for reducing hollow organ volume
DE102004010062B3 (en) 2004-03-02 2005-09-08 Drägerwerk AG Device for dosing substances
DE102004011139B4 (en) 2004-03-08 2011-01-20 Dräger Safety AG & Co. KGaA Method and device for body climate control
DE102004011557A1 (en) 2004-03-08 2005-09-29 Henkel Kgaa Bleaching agents and applicators for the teeth
US8628547B2 (en) 2004-03-09 2014-01-14 Ethicon Endo-Surgery, Inc. Devices and methods for placement of partitions within a hollow body organ
US8252009B2 (en) 2004-03-09 2012-08-28 Ethicon Endo-Surgery, Inc. Devices and methods for placement of partitions within a hollow body organ
US9028511B2 (en) 2004-03-09 2015-05-12 Ethicon Endo-Surgery, Inc. Devices and methods for placement of partitions within a hollow body organ
US20050228415A1 (en) 2004-03-23 2005-10-13 Michael Gertner Methods and devices for percutaneous, non-laparoscopic treatment of obesity
CA2561193A1 (en) 2004-03-26 2005-10-20 Satiety, Inc. Systems and methods for treating obesity
EP1750595A4 (en) * 2004-05-07 2008-10-22 Valentx Inc Devices and methods for attaching an endolumenal gastrointestinal implant
US20060020254A1 (en) * 2004-05-10 2006-01-26 Hoffmann Gerard V Suction assisted tissue plication device and method of use
US20060020276A1 (en) * 2004-07-23 2006-01-26 Usgi Medical Inc. Apparatus and methods for achieving prolonged maintenance of gastrointestinal tissue folds
US20060036267A1 (en) * 2004-08-11 2006-02-16 Usgi Medical Inc. Methods and apparatus for performing malabsorptive bypass procedures within a patient's gastro-intestinal lumen
US20060106288A1 (en) 2004-11-17 2006-05-18 Roth Alex T Remote tissue retraction device
US7641671B2 (en) 2004-11-22 2010-01-05 Design Standards Corporation Closing assemblies for clamping device
US7771382B2 (en) 2005-01-19 2010-08-10 Gi Dynamics, Inc. Resistive anti-obesity devices

Patent Citations (40)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4547192A (en) 1982-11-12 1985-10-15 Superior Plastic Products Corp. Gastroenteric feeding tube
US4790294A (en) 1987-07-28 1988-12-13 Welch Allyn, Inc. Ball-and-socket bead endoscope steering section
US5330503A (en) 1989-05-16 1994-07-19 Inbae Yoon Spiral suture needle for joining tissue
US5626588A (en) 1992-04-30 1997-05-06 Lasersurge, Inc. Trocar wound closure device
US5327914A (en) 1992-09-02 1994-07-12 Shlain Leonard M Method and devices for use in surgical gastroplastic procedure
US5345949A (en) 1992-09-02 1994-09-13 Shlain Leonard M Methods for use in surgical gastroplastic procedure
US5382231A (en) 1993-02-02 1995-01-17 Shlain; Leonard M. Method for transesophageal retraction of the stomach
US5728178A (en) 1993-03-25 1998-03-17 The Ohio State University Guide tube for gastrostomy tube placement
US5749893A (en) 1993-04-30 1998-05-12 United States Surgical Corporation Surgical instrument having an articulated jaw structure and a detachable knife
US5549621A (en) 1993-05-14 1996-08-27 Byron C. Sutherland Apparatus and method for performing vertical banded gastroplasty
US5437291A (en) 1993-08-26 1995-08-01 Univ Johns Hopkins Method for treating gastrointestinal muscle disorders and other smooth muscle dysfunction
US5792153A (en) 1994-03-23 1998-08-11 University College London Sewing device
US5824008A (en) 1994-08-05 1998-10-20 Origin Medsystems, Inc. System for applying fasteners to tissue
US5964772A (en) 1994-08-05 1999-10-12 Origin Medsystems, Inc. Applicator for attaching fasteners to tissue
US5810882A (en) 1994-08-05 1998-09-22 Origin Medsystems, Inc. Surgical helical fastener with applicator and method of use
US5582616A (en) 1994-08-05 1996-12-10 Origin Medsystems, Inc. Surgical helical fastener with applicator
US5624381A (en) 1994-08-09 1997-04-29 Kieturakis; Maciej J. Surgical instrument and method for retraction of an anatomic structure defining an interior lumen
US5571116A (en) 1994-10-02 1996-11-05 United States Surgical Corporation Non-invasive treatment of gastroesophageal reflux disease
US5690656A (en) 1995-06-27 1997-11-25 Cook Incorporated Method and apparatus for creating abdominal visceral anastomoses
US5651769A (en) 1995-10-16 1997-07-29 The Beth Israel Hospital Association Method for retrieving pancreatic juice utilizing and endoscopically wire-guided catheter
US5827298A (en) 1995-11-17 1998-10-27 Innovasive Devices, Inc. Surgical fastening system and method for using the same
US6197022B1 (en) 1996-07-30 2001-03-06 James A. Baker Medical instruments and techniques for treatment of gastro-esophageal reflux disease
US5897534A (en) 1996-08-29 1999-04-27 Team Medical, Llc Body fluids and solids drainage system
US5868141A (en) 1997-05-14 1999-02-09 Ellias; Yakub A. Endoscopic stomach insert for treating obesity and method for use
US5964782A (en) 1997-09-18 1999-10-12 Scimed Life Systems, Inc. Closure device and method
US5976161A (en) 1998-01-07 1999-11-02 University Of New Mexico Tissue everting apparatus and method
US5947983A (en) 1998-03-16 1999-09-07 Boston Scientific Corporation Tissue cutting and stitching device and method
US20020072761A1 (en) 1998-05-11 2002-06-13 Surgical Connections, Inc. Surgical stabilizer devices and methods
US6113609A (en) 1998-05-26 2000-09-05 Scimed Life Systems, Inc. Implantable tissue fastener and system for treating gastroesophageal reflux disease
US6447533B1 (en) 1998-05-26 2002-09-10 Scimed Life Systems, Inc. Implantable tissue fastener and system for treating gastroesophageal reflux disease
US6179195B1 (en) 1998-06-19 2001-01-30 Scimed Life Systems, Inc. Method and device for full thickness resectioning of an organ
US6067991A (en) 1998-08-13 2000-05-30 Forsell; Peter Mechanical food intake restriction device
US6042538A (en) 1998-11-18 2000-03-28 Emory University Device for endoscopic vessel harvesting
US6159146A (en) 1999-03-12 2000-12-12 El Gazayerli; Mohamed Mounir Method and apparatus for minimally-invasive fundoplication
US6231561B1 (en) 1999-09-20 2001-05-15 Appriva Medical, Inc. Method and apparatus for closing a body lumen
US6328689B1 (en) * 2000-03-23 2001-12-11 Spiration, Inc., Lung constriction apparatus and method
WO2001085034A1 (en) 2000-05-10 2001-11-15 Boston Scientific Limited Devices and related methods for securing a tissue fold
US20020082621A1 (en) 2000-09-22 2002-06-27 Schurr Marc O. Methods and devices for folding and securing tissue
WO2002039880A2 (en) 2000-11-14 2002-05-23 Biomedical Engineering Solutions, Inc. Method and system for internal ligation of tubular structures
US20020078967A1 (en) 2000-12-06 2002-06-27 Robert Sixto Methods for the endoluminal treatment of gastroesophageal reflux disease (GERD)

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
U.S. patent application Ser. No. 60/234,360, Schurr, filed Sep. 22, 2000.

Cited By (927)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20090118699A1 (en) * 1998-02-19 2009-05-07 Respiratory Diagnostic, Inc. Systems and methods for treating obesity and other gastrointestinal conditions
US20040089313A1 (en) * 1998-02-19 2004-05-13 Curon Medical, Inc. Systems and methods for treating obesity and other gastrointestinal conditions
US7468060B2 (en) * 1998-02-19 2008-12-23 Respiratory Diagnostic, Inc. Systems and methods for treating obesity and other gastrointestinal conditions
US7326207B2 (en) 1999-05-18 2008-02-05 Curon Medical, Inc. Surgical weight control device
US20110224768A1 (en) * 1999-05-18 2011-09-15 Mederi Therapeutics Inc. Surgical weight control systems and methods
US7947038B2 (en) 1999-05-18 2011-05-24 Mederi Therapeutics Inc. Obesity treatment system including inflatable balloon structures with micropores for transport of liquid
US20080108988A1 (en) * 1999-05-18 2008-05-08 Edwards Stuart D Surgical weight control systems and methods
US8740894B2 (en) 1999-05-18 2014-06-03 Mederi Therapeutics Inc. Surgical weight control systems and methods
US7722633B2 (en) 1999-06-22 2010-05-25 Ethicon Endo-Surgery, Inc. Tissue reconfiguration
US20040133238A1 (en) * 1999-06-22 2004-07-08 Cerier Jeffrey C. Tissue fixation devices and methods of fixing tissue
US7713277B2 (en) 1999-06-22 2010-05-11 Ethicon Endo-Surgery, Inc. Tissue reconfiguration
US7857823B2 (en) 1999-06-22 2010-12-28 Ethicon Endo-Surgery, Inc. Tissue reconfiguration
US8287554B2 (en) 1999-06-22 2012-10-16 Ethicon Endo-Surgery, Inc. Method and devices for tissue reconfiguration
US8277468B2 (en) 1999-06-22 2012-10-02 Ethicon Endo-Surgery, Inc. Tissue reconfiguration
US20040193194A1 (en) * 1999-06-22 2004-09-30 Ndo Surgical, Inc., A Massachusetts Corporation Tissue reconfiguration
US7776057B2 (en) 1999-06-22 2010-08-17 Ethicon Endo-Surgery, Inc. Methods and devices for tissue reconfiguration
US7736373B2 (en) 1999-06-22 2010-06-15 Ndo Surical, Inc. Methods and devices for tissue reconfiguration
US8057494B2 (en) 1999-06-22 2011-11-15 Ethicon Endo-Surgery, Inc. Methods and devices for tissue reconfiguration
US7896893B2 (en) 1999-06-22 2011-03-01 Ethicon Endo-Surgery, Inc. Methods and devices for tissue reconfiguration
US20020193816A1 (en) * 1999-06-22 2002-12-19 Ndo Surgical, Inc., A Delaware Corporation Tissue reconfiguration
US7846180B2 (en) 1999-06-22 2010-12-07 Ethicon Endo-Surgery, Inc. Tissue fixation devices and methods of fixing tissue
US7955340B2 (en) 1999-06-25 2011-06-07 Usgi Medical, Inc. Apparatus and methods for forming and securing gastrointestinal tissue folds
US7704264B2 (en) 1999-06-25 2010-04-27 Usgi Medical, Inc. Apparatus and methods for forming and securing gastrointestinal tissue folds
US8574243B2 (en) 1999-06-25 2013-11-05 Usgi Medical, Inc. Apparatus and methods for forming and securing gastrointestinal tissue folds
US8343175B2 (en) 1999-06-25 2013-01-01 Usgi Medical, Inc. Apparatus and methods for forming and securing gastrointestinal tissue folds
US7744613B2 (en) 1999-06-25 2010-06-29 Usgi Medical, Inc. Apparatus and methods for forming and securing gastrointestinal tissue folds
US8152821B2 (en) 2000-03-03 2012-04-10 C.R. Bard, Inc. Endoscopic tissue apposition device with multiple suction ports
US20080215069A1 (en) * 2000-03-03 2008-09-04 C.R. Bard, Inc. Endoscopic tissue apposition device with multiple suction ports
US8518062B2 (en) 2000-04-29 2013-08-27 Medtronic, Inc. Devices and methods for forming magnetic anastomoses between vessels
US20110184505A1 (en) * 2000-04-29 2011-07-28 Medtronic, Inc. Components, Systems and Methods for Forming Anastomoses Using Magnetism or Other Coupling Means
US20070010834A1 (en) * 2000-04-29 2007-01-11 Sharkawy A A Components, systems and methods for forming anastomoses using magnetism or other coupling means
US20050021059A1 (en) * 2000-04-29 2005-01-27 Cole David H. Magnetic components for use in forming anastomoses, creating ports in vessels and closing openings in tissue
US7938841B2 (en) 2000-04-29 2011-05-10 Medtronic, Inc. Components, systems and methods for forming anastomoses using magnetism or other coupling means
US20050080439A1 (en) * 2000-04-29 2005-04-14 Carson Dean F. Devices and methods for forming magnetic anastomoses and ports in vessels
US20040241768A1 (en) * 2000-05-08 2004-12-02 Whitten David G. Fluorescent polymer-QTL approach to biosensing
US8551120B2 (en) 2000-05-19 2013-10-08 C.R. Bard, Inc. Tissue capturing and suturing device and method
US8388632B2 (en) 2000-05-19 2013-03-05 C.R. Bard, Inc. Tissue capturing and suturing device and method
US7951157B2 (en) 2000-05-19 2011-05-31 C.R. Bard, Inc. Tissue capturing and suturing device and method
US20080147095A1 (en) * 2000-05-19 2008-06-19 C. R. Bard, Inc Tissue capturing and suturing device and method
US20040037865A1 (en) * 2000-08-11 2004-02-26 Miller Larry Sherwin Obesity controlling method
US7737109B2 (en) * 2000-08-11 2010-06-15 Temple University Of The Commonwealth System Of Higher Education Obesity controlling method
US20040009224A1 (en) * 2000-08-11 2004-01-15 Miller Larry S Obesity controlling method
US20070104756A1 (en) * 2000-08-11 2007-05-10 Temple University Of The Commonwealth System Of Higher Education Obesity controlling method
US20100204673A1 (en) * 2000-08-11 2010-08-12 Temple University-Of The Commonwealth System Of Higher Education Obesity controlling method
US7608578B2 (en) * 2000-08-11 2009-10-27 Temple University - Of The Commonwealth System Of Higher Education Obesity controlling method
US20050192615A1 (en) * 2000-11-03 2005-09-01 Torre Roger D.L. Method and device for use in minimally invasive placement of intragastric devices
US7753928B2 (en) 2000-11-03 2010-07-13 Satiety, Inc. Method and device for use in minimally invasive placement of intragastric devices
US6896682B1 (en) * 2000-11-14 2005-05-24 Biomedical Engineering Solutions, Inc. Method and system for internal ligation of tubular structures
US20070276436A1 (en) * 2000-11-20 2007-11-29 Medigus Ltd. Stapler for endoscopes
US20070251975A1 (en) * 2000-11-20 2007-11-01 Medigus Ltd. Stapler for endoscopes
US8807415B2 (en) 2000-11-20 2014-08-19 Medigus Ltd. Stapler for endoscopes
US20070251976A1 (en) * 2000-11-20 2007-11-01 Medigus Ltd. Stapler for endoscopes
US8328827B2 (en) 2000-11-20 2012-12-11 Medigus Ltd. Stapler for endoscopes
US8257373B2 (en) 2000-11-20 2012-09-04 Medigus Ltd. Device for performing a fundoplication surgical procedure
US20090272785A1 (en) * 2000-11-20 2009-11-05 Medigus Ltd. Stapler for endoscopes
US8006886B2 (en) * 2000-11-20 2011-08-30 Medigus Ltd. Stapler for endoscopes
US20070246507A1 (en) * 2000-11-20 2007-10-25 Medigus Ltd. Stapler for endoscopes
US20050192603A1 (en) * 2000-12-13 2005-09-01 Medtronic Avecor Cardiovascular, Inc. A Minnesota Corporation Extravascular anastomotic components and methods for forming magnetic anastomoses
US7909837B2 (en) 2000-12-13 2011-03-22 Medtronic, Inc. Methods, devices and systems for forming magnetic anastomoses
US20040215214A1 (en) * 2000-12-13 2004-10-28 Samuel Crews Methods, devices and systems for forming magnetic anastomoses
US20030078611A1 (en) * 2001-05-17 2003-04-24 Kiyoshi Hashiba Intragastric device for treating obesity
US7066945B2 (en) 2001-05-17 2006-06-27 Wilson-Cook Medical Inc. Intragastric device for treating obesity
US8075577B2 (en) 2001-05-30 2011-12-13 Ethicon Endo-Surgery, Inc. Obesity treatment tools and methods
US7862574B2 (en) 2001-05-30 2011-01-04 Satiety, Inc. Obesity treatment tools and methods
US8080022B2 (en) 2001-05-30 2011-12-20 Ethicon Endo-Surgery, Inc. Obesity treatment tools and methods
US8419755B2 (en) 2001-05-30 2013-04-16 Ethicon Endo-Surgery, Inc. Obesity treatment tools and methods
US8613749B2 (en) 2001-05-30 2013-12-24 Ethicon Endo-Surgery, Inc. Obesity treatment tools and methods
US7909838B2 (en) 2001-05-30 2011-03-22 Satiety, Inc. Obesity treatment tools and methods
US8794243B2 (en) 2001-05-30 2014-08-05 Ethicon Endo-Surgery, Inc. Obesity treatment tools and methods
US8137367B2 (en) 2001-05-30 2012-03-20 Ethicon Endo-Surgery, Inc. Obesity treatment tools and methods
US7083629B2 (en) 2001-05-30 2006-08-01 Satiety, Inc. Overtube apparatus for insertion into a body
US20030065359A1 (en) * 2001-05-30 2003-04-03 Gary Weller Overtube apparatus for insertion into a body
US8080025B2 (en) 2001-05-30 2011-12-20 Ethicon Endo-Surgery, Inc. Obesity treatment tools and methods
US8123765B2 (en) 2001-05-30 2012-02-28 Ethicon Endo-Surgery, Inc. Obesity treatment tools and methods
US8137366B2 (en) 2001-05-30 2012-03-20 Ethicon Endo-Surgery, Inc. Obesity treatment tools and methods
US20040024386A1 (en) * 2001-05-30 2004-02-05 Deem Mark E. Obesity treatment tools and methods
US9943308B2 (en) 2001-06-14 2018-04-17 Endoevolution, Llc Devices and methods for surgical suturing
US9649107B2 (en) 2001-06-14 2017-05-16 Endoevolution, Llc Needle for suturing instrument
US9936945B2 (en) 2001-06-14 2018-04-10 Endoevolution, Llc Devices and methods for surgical suturing
US9737296B1 (en) 2001-06-14 2017-08-22 Endoevolution, Llc Devices and methods for surgical suturing
US9743923B2 (en) 2001-06-14 2017-08-29 Endoevolution, Llc Devices and methods for surgical suturing
US9943307B2 (en) 2001-06-14 2018-04-17 Endoevolution, Llc Devices and methods for surgical suturing
US9730688B1 (en) 2001-06-14 2017-08-15 Endoevolution, Llc Devices and methods for surgical suturing
US9743925B2 (en) 2001-06-14 2017-08-29 Endoevolution, Llc Devices and methods for surgical suturing
US10792032B2 (en) 2001-06-14 2020-10-06 Intuitive Surgical Operations, Inc. Methods of surgical fastening
US9717495B1 (en) 2001-06-14 2017-08-01 Endoevolution, Llc Devices and methods for surgical suturing
US8066737B2 (en) 2001-06-14 2011-11-29 Endoevolution, Llc Needle for suturing instrument
US8623048B2 (en) 2001-06-14 2014-01-07 Endoevolution, Llc Suturing instrument
US9717493B1 (en) 2001-06-14 2017-08-01 Endoevolution, Llc Devices and methods for surgical suturing
US20050216038A1 (en) * 2001-06-14 2005-09-29 Suturtek Incorporated Apparatus for surgical suturing with thread management
US9445807B2 (en) 2001-06-14 2016-09-20 Endoevolution, Llc Needle for suturing instrument
US9962152B2 (en) 2001-06-14 2018-05-08 Endoevolution, Llc Devices and methods for surgical suturing
US9693770B2 (en) 2001-06-14 2017-07-04 Endoevolution, Llc Devices and methods for surgical suturing
US10045774B2 (en) 2001-06-14 2018-08-14 Endoevolution, Llc Devices and methods for surgical fastening
US20170119376A1 (en) 2001-06-14 2017-05-04 Endoevolution, Llc Devices and methods for surgical suturing
US20050004681A1 (en) * 2001-08-27 2005-01-06 Stack Richard S. Satiation devices and methods
US9138340B2 (en) 2001-08-27 2015-09-22 Boston Scientific Scimed, Inc. Gastro-esophageal implants
US9180036B2 (en) 2001-08-27 2015-11-10 Boston Scientific Scimed, Inc. Methods for implanting medical devices
US8784354B2 (en) 2001-08-27 2014-07-22 Boston Scientific Scimed, Inc. Positioning tools and methods for implanting medical devices
US20080208356A1 (en) * 2001-08-27 2008-08-28 Stack Richard S Satiation devices and methods
US6845776B2 (en) * 2001-08-27 2005-01-25 Richard S. Stack Satiation devices and methods
US7121283B2 (en) 2001-08-27 2006-10-17 Synecor, Llc Satiation devices and methods
US8992457B2 (en) 2001-08-27 2015-03-31 Boston Scientific Scimed, Inc. Gastrointestinal implants
US8568488B2 (en) 2001-08-27 2013-10-29 Boston Scientific Scimed, Inc. Satiation devices and methods
US7111627B2 (en) 2001-08-27 2006-09-26 Synecor, Llc Satiation devices and methods
US9844453B2 (en) 2001-08-27 2017-12-19 Boston Scientific Scimed, Inc. Positioning tools and methods for implanting medical devices
US20040172142A1 (en) * 2001-08-27 2004-09-02 Stack Richard S. Satiation devices and methods
US9872786B2 (en) 2001-08-27 2018-01-23 Boston Scientific Scimed, Inc. Gastro-esophageal implants
US20040138761A1 (en) * 2001-08-27 2004-07-15 Stack Richard S. Satiation devices and methods
US20040117031A1 (en) * 2001-08-27 2004-06-17 Stack Richard S. Satiation devices and methods
US10080677B2 (en) 2001-08-27 2018-09-25 Boston Scientific Scimed, Inc. Satiation devices and methods
US7892292B2 (en) 2001-08-27 2011-02-22 Synecor, Llc Positioning tools and methods for implanting medical devices
US7354454B2 (en) 2001-08-27 2008-04-08 Synecor, Llc Satiation devices and methods
US9107727B2 (en) 2001-08-27 2015-08-18 Boston Scientific Scimed, Inc. Satiation devices and methods
US7981162B2 (en) 2001-08-27 2011-07-19 Barosense, Inc. Satiation devices and methods
US9788984B2 (en) 2001-08-27 2017-10-17 Boston Scientific Scimed, Inc. Satiation devices and methods
US20080269797A1 (en) * 2001-08-27 2008-10-30 Stack Richard S Satiation devices and methods
US8845753B2 (en) 2001-08-27 2014-09-30 Boston Scientific Scimed, Inc. Satiation devices and methods
US20030199991A1 (en) * 2001-08-27 2003-10-23 Stack Richard S. Satiation devices and methods
US9358144B2 (en) 2001-08-27 2016-06-07 Boston Scientific Scimed, Inc. Gastrointestinal implants
US7833280B2 (en) 2001-08-27 2010-11-16 Barosense, Inc. Satiation devices and methods
US20090299487A1 (en) * 2001-08-27 2009-12-03 Stack Richard S Satiation devices and methods
US20030199990A1 (en) * 2001-08-27 2003-10-23 Stack Richard S. Satiation devices and methods
US9254214B2 (en) 2001-08-27 2016-02-09 Boston Scientific Scimed, Inc. Satiation devices and methods
US20030199989A1 (en) * 2001-08-27 2003-10-23 Stack Richard S. Satiation devices and methods
US20030040808A1 (en) * 2001-08-27 2003-02-27 Stack Richard S. Satiation devices and methods
US7883514B2 (en) * 2002-01-23 2011-02-08 Ophtec B.V. Fixation of an intraocular implant to the iris
US20040225357A1 (en) * 2002-01-23 2004-11-11 Ophtec B.V. Fixation of an intraocular implant to the iris
US20030191479A1 (en) * 2002-04-03 2003-10-09 Thornton Sally C. Body lumen closure
US7628821B2 (en) 2002-04-08 2009-12-08 Barosense, Inc. Obesity treatment method
US7146984B2 (en) 2002-04-08 2006-12-12 Synecor, Llc Method and apparatus for modifying the exit orifice of a satiation pouch
US8337566B2 (en) 2002-04-08 2012-12-25 Barosense, Inc. Method and apparatus for modifying the exit orifice of a satiation pouch
US20040158331A1 (en) * 2002-04-08 2004-08-12 Stack Richard S. Method and apparatus for modifying the exit orifice of a satiation pouch
US20050267499A1 (en) * 2002-04-08 2005-12-01 Stack Richard S Method and apparatus for modifying the exit orifice of a satiation pouch
US20080255590A1 (en) * 2002-04-22 2008-10-16 Meade John C Apparatus and method for minimally invasive suturing
US9433410B2 (en) 2002-05-01 2016-09-06 Boston Scientific Scimed, Inc. Tissue fastening devices and related insertion tools and methods
US20070021756A1 (en) * 2002-05-01 2007-01-25 Scimed Life Systems, Inc. Tissue fastening devices and related insertion tools and methods
US7811295B2 (en) * 2002-05-01 2010-10-12 Boston Scientific Scimed, Inc. Tissue fastening devices and related insertion tools and methods
US20050274280A1 (en) * 2002-07-27 2005-12-15 Avecia Limited Metal chelate compounds and inks
US8062207B2 (en) 2002-08-07 2011-11-22 Ethicon Endo-Surgery, Inc. Intra-gastric fastening devices
US6994715B2 (en) 2002-08-07 2006-02-07 Satiety, Inc. Intra-gastric fastening devices
US20040093091A1 (en) * 2002-08-07 2004-05-13 Jamy Gannoe Intra-gastric fastening devices
US8083756B2 (en) 2002-08-30 2011-12-27 Ethicon Endo-Surgery, Inc. Methods and devices for maintaining a space occupying device in a relatively fixed location within a stomach
US8083757B2 (en) 2002-08-30 2011-12-27 Ethicon Endo-Surgery, Inc. Methods and devices for maintaining a space occupying device in a relatively fixed location within a stomach
US8092482B2 (en) 2002-08-30 2012-01-10 Ethicon Endo-Surgery, Inc. Stented anchoring of gastric space-occupying devices
US7947055B2 (en) 2002-08-30 2011-05-24 Ethicon Endo-Surgery, Inc. Methods and devices for maintaining a space occupying device in a relatively fixed location within a stomach
US8206284B2 (en) 2002-09-06 2012-06-26 C.R. Bard, Inc. Integrated endoscope and accessory treatment device
US8057386B2 (en) 2002-09-06 2011-11-15 C.R. Bard, Inc. Integrated endoscope and accessory treatment device
US20100160934A1 (en) * 2002-09-09 2010-06-24 Brian Kelleher Device and Method for Endoluminal Therapy
US10342690B2 (en) 2002-09-09 2019-07-09 Brian Kelleher Device and method for endoluminal therapy
US8449558B2 (en) * 2002-09-09 2013-05-28 Brian Kelleher Device and method for endoluminal therapy
US7976556B2 (en) * 2002-09-12 2011-07-12 Medtronic, Inc. Anastomosis apparatus and methods
US20070106313A1 (en) * 2002-09-12 2007-05-10 Steve Golden Anastomosis apparatus and methods
US7789848B2 (en) 2002-10-23 2010-09-07 Satiety, Inc. Method and device for use in endoscopic organ procedures
US7220237B2 (en) * 2002-10-23 2007-05-22 Satiety, Inc. Method and device for use in endoscopic organ procedures
US20040082963A1 (en) * 2002-10-23 2004-04-29 Jamy Gannoe Method and device for use in endoscopic organ procedures
US8147441B2 (en) 2002-10-23 2012-04-03 Ethicon Endo-Surgery, Inc. Method and device for use in endoscopic organ procedures
US7229428B2 (en) * 2002-10-23 2007-06-12 Satiety, Inc. Method and device for use in endoscopic organ procedures
US8801650B2 (en) 2002-10-23 2014-08-12 Ethicon Endo-Surgery, Inc. Method and device for use in endoscopic organ procedures
US20060020247A1 (en) * 2002-11-01 2006-01-26 Jonathan Kagan Devices and methods for attaching an endolumenal gastrointestinal implant
US20050049718A1 (en) * 2002-11-01 2005-03-03 Valentx, Inc. Gastrointestinal sleeve device and methods for treatment of morbid obesity
US7846138B2 (en) 2002-11-01 2010-12-07 Valentx, Inc. Cuff and sleeve system for gastrointestinal bypass
US20060206064A1 (en) * 2002-11-01 2006-09-14 Jonathan Kagan Methods of adjusting therapy in a patient having an endolumenal bypass to treat obesity
US20060206063A1 (en) * 2002-11-01 2006-09-14 Jonathan Kagan Attachment system for transmural attachment at the gastroesophageal junction
US7837669B2 (en) 2002-11-01 2010-11-23 Valentx, Inc. Devices and methods for endolumenal gastrointestinal bypass
US20070010864A1 (en) * 2002-11-01 2007-01-11 Mitchell Dann Gastrointestinal implant system
US20070010865A1 (en) * 2002-11-01 2007-01-11 Mitchell Dann Everting gastrointestinal sleeve
US9060844B2 (en) 2002-11-01 2015-06-23 Valentx, Inc. Apparatus and methods for treatment of morbid obesity
US20050240279A1 (en) * 2002-11-01 2005-10-27 Jonathan Kagan Gastrointestinal sleeve device and methods for treatment of morbid obesity
US20040092892A1 (en) * 2002-11-01 2004-05-13 Jonathan Kagan Apparatus and methods for treatment of morbid obesity
US20070010794A1 (en) * 2002-11-01 2007-01-11 Mitchell Dann Devices and methods for endolumenal gastrointestinal bypass
US20090149871A9 (en) * 2002-11-01 2009-06-11 Jonathan Kagan Devices and methods for treating morbid obesity
US7892214B2 (en) 2002-11-01 2011-02-22 Valentx, Inc. Attachment system for transmural attachment at the gastroesophageal junction
US8012140B1 (en) 2002-11-01 2011-09-06 Valentx, Inc. Methods of transmural attachment in the gastrointestinal system
US8012135B2 (en) 2002-11-01 2011-09-06 Valentx, Inc. Attachment cuff for gastrointestinal implant
US20070198074A1 (en) * 2002-11-01 2007-08-23 Mitchell Dann Devices and methods for endolumenal gastrointestinal bypass
US10350101B2 (en) 2002-11-01 2019-07-16 Valentx, Inc. Devices and methods for endolumenal gastrointestinal bypass
US7220284B2 (en) 2002-11-01 2007-05-22 Valentx, Inc. Gastrointestinal sleeve device and methods for treatment of morbid obesity
US20060293742A1 (en) * 2002-11-01 2006-12-28 Mitchell Dann Cuff and sleeve system for gastrointestinal bypass
US8968270B2 (en) 2002-11-01 2015-03-03 Valentx, Inc. Methods of replacing a gastrointestinal bypass sleeve for therapy adjustment
US8182459B2 (en) 2002-11-01 2012-05-22 Valentx, Inc. Devices and methods for endolumenal gastrointestinal bypass
US9839546B2 (en) 2002-11-01 2017-12-12 Valentx, Inc. Apparatus and methods for treatment of morbid obesity
US9561127B2 (en) 2002-11-01 2017-02-07 Valentx, Inc. Apparatus and methods for treatment of morbid obesity
US7794447B2 (en) 2002-11-01 2010-09-14 Valentx, Inc. Gastrointestinal sleeve device and methods for treatment of morbid obesity
US20050177181A1 (en) * 2002-11-01 2005-08-11 Jonathan Kagan Devices and methods for treating morbid obesity
US8070743B2 (en) 2002-11-01 2011-12-06 Valentx, Inc. Devices and methods for attaching an endolumenal gastrointestinal implant
US7211094B2 (en) * 2002-11-05 2007-05-01 Satiety, Inc. Magnetic anchoring devices
US8617189B2 (en) 2002-11-29 2013-12-31 John R. Liddicoat Apparatus and method for manipulating tissue
US7892245B2 (en) 2002-11-29 2011-02-22 Liddicoat John R Apparatus and method for manipulating tissue
US20040193190A1 (en) * 2002-11-29 2004-09-30 Liddicoat John R. Apparatus and method for manipulating tissue
WO2004050971A3 (en) * 2002-11-29 2004-11-04 John R Liddicoat Apparatus and method for manipulating tissue
AU2003293191B2 (en) * 2002-11-29 2008-08-07 William E. Cohn Apparatus and method for manipulating tissue
US9750596B2 (en) 2002-12-02 2017-09-05 Gi Dynamics, Inc. Bariatric sleeve
US8882698B2 (en) 2002-12-02 2014-11-11 Gi Dynamics, Inc. Anti-obesity devices
US8870806B2 (en) 2002-12-02 2014-10-28 Gi Dynamics, Inc. Methods of treatment using a bariatric sleeve
US7766861B2 (en) 2002-12-02 2010-08-03 Gi Dynamics, Inc. Anti-obesity devices
US20080103604A1 (en) * 2002-12-02 2008-05-01 Levine Andy H Methods of treatment using a bariatric sleeve
US7758535B2 (en) 2002-12-02 2010-07-20 Gi Dynamics, Inc. Bariatric sleeve delivery devices
US8486153B2 (en) 2002-12-02 2013-07-16 Gi Dynamics, Inc. Anti-obesity devices
US20060161265A1 (en) * 2002-12-02 2006-07-20 Levine Andy H Bariatric sleeve
US20050085923A1 (en) * 2002-12-02 2005-04-21 Gi Dynamics, Inc. Anti-obesity devices
US9901474B2 (en) 2002-12-02 2018-02-27 Gi Dynamics, Inc. Anti-obesity devices
US7935073B2 (en) 2002-12-02 2011-05-03 Gi Dynamics, Inc. Methods of treatment using a bariatric sleeve
US7347875B2 (en) 2002-12-02 2008-03-25 Gi Dynamics, Inc. Methods of treatment using a bariatric sleeve
US8137301B2 (en) 2002-12-02 2012-03-20 Gi Dynamics, Inc. Bariatric sleeve
US7122058B2 (en) 2002-12-02 2006-10-17 Gi Dynamics, Inc. Anti-obesity devices
US9278020B2 (en) 2002-12-02 2016-03-08 Gi Dynamics, Inc. Methods of treatment using a bariatric sleeve
US7025791B2 (en) 2002-12-02 2006-04-11 Gi Dynamics, Inc. Bariatric sleeve
US7695446B2 (en) 2002-12-02 2010-04-13 Gi Dynamics, Inc. Methods of treatment using a bariatric sleeve
US7678068B2 (en) 2002-12-02 2010-03-16 Gi Dynamics, Inc. Atraumatic delivery devices
US20040107004A1 (en) * 2002-12-02 2004-06-03 Seedling Enterprises, Llc Bariatric sleeve
US9155609B2 (en) 2002-12-02 2015-10-13 Gi Dynamics, Inc. Bariatric sleeve
US8162871B2 (en) 2002-12-02 2012-04-24 Gi Dynamics, Inc. Bariatric sleeve
US8216260B2 (en) 2002-12-11 2012-07-10 Usgi Medical, Inc. Apparatus and methods for forming and securing gastrointestinal tissue folds
US7942884B2 (en) 2002-12-11 2011-05-17 Usgi Medical, Inc. Methods for reduction of a gastric lumen
US7942898B2 (en) 2002-12-11 2011-05-17 Usgi Medical, Inc. Delivery systems and methods for gastric reduction
US8262676B2 (en) 2002-12-11 2012-09-11 Usgi Medical, Inc. Apparatus and methods for forming gastrointestinal tissue approximations
US8066719B2 (en) 2002-12-11 2011-11-29 Ewers Richard C Apparatus and methods for forming gastrointestinal tissue approximations
US7918845B2 (en) 2003-01-15 2011-04-05 Usgi Medical, Inc. Endoluminal tool deployment system
US20040143342A1 (en) * 2003-01-16 2004-07-22 Stack Richard S. Satiation pouches and methods of use
US8029455B2 (en) 2003-01-16 2011-10-04 Barosense, Inc. Satiation pouches and methods of use
US20040249362A1 (en) * 2003-03-28 2004-12-09 Gi Dynamics, Inc. Enzyme sleeve
US8231641B2 (en) 2003-04-16 2012-07-31 Ethicon Endo-Surgery, Inc. Method and devices for modifying the function of a body organ
WO2004093639A3 (en) * 2003-04-16 2005-04-28 Satiety Inc Method and devices for modifying the function of a body organ
WO2004093639A2 (en) * 2003-04-16 2004-11-04 Satiety, Inc. Method and devices for modifying the function of a body organ
US20040210243A1 (en) * 2003-04-16 2004-10-21 Jamy Gannoe Method and devices for modifying the function of a body organ
US8075573B2 (en) 2003-05-16 2011-12-13 C.R. Bard, Inc. Single intubation, multi-stitch endoscopic suturing system
US20090118757A1 (en) * 2003-07-28 2009-05-07 Burnett Daniel R Pyloric valve obstructing devices and methods
US9642735B2 (en) 2003-07-28 2017-05-09 Baronova, Inc. Pyloric valve corking device
US8048169B2 (en) 2003-07-28 2011-11-01 Baronova, Inc. Pyloric valve obstructing devices and methods
US11197774B2 (en) 2003-07-28 2021-12-14 Baronova, Inc. Devices and methods for gastrointestinal stimulation
US20050033332A1 (en) * 2003-07-28 2005-02-10 Burnett Daniel R. Pyloric valve corking device and method
US20050033331A1 (en) * 2003-07-28 2005-02-10 Polymorfix, Inc., C/O Medventure Associates Pyloric valve obstructing devices and methods
US9700450B2 (en) 2003-07-28 2017-07-11 Baronova, Inc. Devices and methods for gastrointestinal stimulation
US8821521B2 (en) 2003-07-28 2014-09-02 Baronova, Inc. Gastro-intestinal device and method for treating addiction
US20050055039A1 (en) * 2003-07-28 2005-03-10 Polymorfix, Inc. Devices and methods for pyloric anchoring
US20090187200A1 (en) * 2003-07-28 2009-07-23 Daniel Rogers Burnett Gastric retaining devices and methods
US20060020278A1 (en) * 2003-07-28 2006-01-26 Polymorfix, Inc. Gastric retaining devices and methods
US20090187201A1 (en) * 2003-07-28 2009-07-23 Daniel Rogers Burnett Gastric retaining devices and methods
US9687243B2 (en) 2003-07-28 2017-06-27 Baronova, Inc. Gastric retaining devices and methods
US9498366B2 (en) 2003-07-28 2016-11-22 Baronova, Inc. Devices and methods for pyloric anchoring
US20090216262A1 (en) * 2003-07-28 2009-08-27 Burnett Daniel R Gastric retaining devices and methods
US20070250132A1 (en) * 2003-07-28 2007-10-25 Baronova, Inc. Devices and methods for gastrointestinal stimulation
US20070178160A1 (en) * 2003-07-28 2007-08-02 Baronova, Inc. Gastro-intestinal device and method for treating addiction
US20090259236A2 (en) * 2003-07-28 2009-10-15 Baronova, Inc. Gastric retaining devices and methods
US9924948B2 (en) 2003-07-28 2018-03-27 Baronova, Inc. Gastric retaining devices and methods
US9931122B2 (en) 2003-07-28 2018-04-03 Baronova, Inc. Gastric retaining devices and methods
US8663338B2 (en) 2003-07-28 2014-03-04 Baronova, Inc. Pyloric valve obstructing devices and methods
US6994095B2 (en) 2003-07-28 2006-02-07 Medventure Associates Iv Pyloric valve corking device and method
US9510834B2 (en) 2003-07-28 2016-12-06 Baronova, Inc. Gastric retaining devices and methods
US20090118758A1 (en) * 2003-07-28 2009-05-07 Burnett Daniel R Pyloric valve obstructing devices and methods
US8657885B2 (en) 2003-07-28 2014-02-25 Baronova, Inc. Pyloric valve obstructing devices and methods
US8192455B2 (en) 2003-08-13 2012-06-05 Board Of Supervisors Of Louisiana State University And Agricultural And Mechanical College Compressive device for percutaneous treatment of obesity
US20070060940A1 (en) * 2003-08-13 2007-03-15 Augusto Brazzini Compressive device for percutaneous treatment of obesity
WO2005020802A3 (en) * 2003-09-02 2005-12-29 Univ Creighton Suturing devices and methods
WO2005020802A2 (en) * 2003-09-02 2005-03-10 Creighton University Suturing devices and methods
US8211142B2 (en) 2003-09-30 2012-07-03 Ortiz Mark S Method for hybrid gastro-jejunostomy
US7452363B2 (en) 2003-09-30 2008-11-18 Ethicon Endo-Surgery, Inc. Applier for fastener for single lumen access anastomosis
US20060217748A1 (en) * 2003-09-30 2006-09-28 Ethicon Endo-Surgery, Inc. Method for Hybrid Gastro-Jejunostomy
US20050070926A1 (en) * 2003-09-30 2005-03-31 Ortiz Mark S. Applier for fastener for single lumen access anastomosis
US10285836B2 (en) 2003-10-10 2019-05-14 Boston Scientific Scimed, Inc. Systems and methods related to gastro-esophageal implants
US20070060932A1 (en) * 2003-10-10 2007-03-15 Synecor, Llc Devices and methods for retaining a gastro-esophageal implant
US9248038B2 (en) 2003-10-10 2016-02-02 Boston Scientific Scimed, Inc. Methods for retaining a gastro-esophageal implant
US20080065122A1 (en) * 2003-10-10 2008-03-13 Stack Richard S Restrictive and/or obstructive implant system for inducing weight loss
US8206456B2 (en) 2003-10-10 2012-06-26 Barosense, Inc. Restrictive and/or obstructive implant system for inducing weight loss
US9180035B2 (en) 2003-10-10 2015-11-10 Boston Scientific Scimed, Inc. Devices and methods for retaining a gastro-esophageal implant
US20130012863A1 (en) * 2003-10-10 2013-01-10 Barosense, Inc. Restrictive and/or obstructive implant system for inducing weight loss
US20050247320A1 (en) * 2003-10-10 2005-11-10 Stack Richard S Devices and methods for retaining a gastro-esophageal implant
US9445791B2 (en) * 2003-10-10 2016-09-20 Boston Scientific Scimed, Inc. Systems and methods related to gastro-esophageal implants
US7914543B2 (en) 2003-10-14 2011-03-29 Satiety, Inc. Single fold device for tissue fixation
US20110172685A1 (en) * 2003-10-14 2011-07-14 Kraemer Stefan J M Transesophageal gastric reduction device, system and method
US20070260276A1 (en) * 2003-10-14 2007-11-08 Esophyx, Inc. Transesophageal gastric reduction device, system and method
US8430891B2 (en) * 2003-10-14 2013-04-30 Endogastric Solutions, Inc. Transesophageal gastric reduction device, system and method
US8357174B2 (en) 2003-10-14 2013-01-22 Roth Alex T Single fold device for tissue fixation
US9186268B2 (en) 2003-10-14 2015-11-17 Ethicon Endo-Surgery, Inc. Single fold device for tissue fixation
US20050080438A1 (en) * 2003-10-14 2005-04-14 Gary Weller System for tissue approximation and fixation
US8007505B2 (en) 2003-10-14 2011-08-30 Ethicon Eado-Surgery, Inc. System for tissue approximation and fixation
US20100286745A1 (en) * 2003-10-22 2010-11-11 Intrapace, Inc. Radially Expandable Gastrointestinal Stimulation Device
US7758493B2 (en) 2003-10-23 2010-07-20 Proxy Biomedical Limited Gastric constriction device
US10238517B2 (en) 2003-10-23 2019-03-26 Proxy Biomedical Limited Gastric constriction device
US20050119674A1 (en) * 2003-10-23 2005-06-02 Peter Gingras Gastric constriction device
US20110004054A1 (en) * 2003-10-23 2011-01-06 Proxy Biomedical Limited Gastric Constriction Device
US8057420B2 (en) 2003-12-09 2011-11-15 Gi Dynamics, Inc. Gastrointestinal implant with drawstring
US8303669B2 (en) 2003-12-09 2012-11-06 Gi Dynamics, Inc. Methods and apparatus for anchoring within the gastrointestinal tract
US9084669B2 (en) 2003-12-09 2015-07-21 Gi Dynamics, Inc. Methods and apparatus for anchoring within the gastrointestinal tract
US9744061B2 (en) 2003-12-09 2017-08-29 Gi Dynamics, Inc. Intestinal sleeve
US8771219B2 (en) 2003-12-09 2014-07-08 Gi Dynamics, Inc. Gastrointestinal implant with drawstring
US7981163B2 (en) 2003-12-09 2011-07-19 Gi Dynamics, Inc. Intestinal sleeve
US20050125075A1 (en) * 2003-12-09 2005-06-09 Gi Dynamics, Inc. Intestinal sleeve
US8628583B2 (en) 2003-12-09 2014-01-14 Gi Dynamics, Inc. Methods and apparatus for anchoring within the gastrointestinal tract
US9095416B2 (en) 2003-12-09 2015-08-04 Gi Dynamics, Inc. Removal and repositioning devices
US7682330B2 (en) * 2003-12-09 2010-03-23 Gi Dynamics, Inc. Intestinal sleeve
US8834405B2 (en) 2003-12-09 2014-09-16 Gi Dynamics, Inc. Intestinal sleeve
US9585783B2 (en) 2003-12-09 2017-03-07 Gi Dynamics, Inc. Methods and apparatus for anchoring within the gastrointestinal tract
US7815589B2 (en) 2003-12-09 2010-10-19 Gi Dynamics, Inc. Methods and apparatus for anchoring within the gastrointestinal tract
US9237944B2 (en) 2003-12-09 2016-01-19 Gi Dynamics, Inc. Intestinal sleeve
US10045871B2 (en) 2003-12-12 2018-08-14 Usgi Medical, Inc. Apparatus for manipulating and securing tissue
US9510817B2 (en) 2003-12-12 2016-12-06 Usgi Medical, Inc. Apparatus for manipulating and securing tissue
US7757924B2 (en) 2004-02-05 2010-07-20 Satiety, Inc. Single fold system for tissue approximation and fixation
US20050177176A1 (en) * 2004-02-05 2005-08-11 Craig Gerbi Single-fold system for tissue approximation and fixation
US8590761B2 (en) 2004-02-05 2013-11-26 Ethicon Endo-Surgery, Inc. Single fold system for tissue approximation and fixation
US20100215733A1 (en) * 2004-02-10 2010-08-26 Paolo Costa Device and method for reducing calorie intake
US9220688B2 (en) 2004-02-10 2015-12-29 Slendine Sa Device and method for reducing calorie intake
US20100196470A1 (en) * 2004-02-10 2010-08-05 Paolo Costa Device and method for reducing calorie intake
US9724306B2 (en) 2004-02-10 2017-08-08 Slendine Ag Device and method for reducing calorie intake
US11786474B2 (en) 2004-02-10 2023-10-17 Biolumen Inc. Device and method for reducing calorie intake
US8828025B2 (en) 2004-02-13 2014-09-09 Ethicon Endo-Surgery, Inc. Methods and devices for reducing hollow organ volume
US8257365B2 (en) 2004-02-13 2012-09-04 Ethicon Endo-Surgery, Inc. Methods and devices for reducing hollow organ volume
US8057384B2 (en) 2004-02-27 2011-11-15 Ethicon Endo-Surgery, Inc. Methods and devices for reducing hollow organ volume
US7708684B2 (en) 2004-02-27 2010-05-04 Satiety, Inc. Methods and devices for reducing hollow organ volume
US8449560B2 (en) * 2004-03-09 2013-05-28 Satiety, Inc. Devices and methods for placement of partitions within a hollow body organ
US8628547B2 (en) * 2004-03-09 2014-01-14 Ethicon Endo-Surgery, Inc. Devices and methods for placement of partitions within a hollow body organ
US20050203548A1 (en) * 2004-03-09 2005-09-15 Gary Weller Devices and methods for placement of partitions within a hollow body organ
US7703459B2 (en) 2004-03-09 2010-04-27 Usgi Medical, Inc. Apparatus and methods for mapping out endoluminal gastrointestinal surgery
US20070167960A1 (en) * 2004-03-09 2007-07-19 Roth Alex T Devices and methods for placement of partitions within a hollow body organ
US20050203547A1 (en) * 2004-03-09 2005-09-15 Gary Weller Devices and methods for placement of partitions within a hollow body organ
US8252009B2 (en) * 2004-03-09 2012-08-28 Ethicon Endo-Surgery, Inc. Devices and methods for placement of partitions within a hollow body organ
US9028511B2 (en) * 2004-03-09 2015-05-12 Ethicon Endo-Surgery, Inc. Devices and methods for placement of partitions within a hollow body organ
US20070167982A1 (en) * 2004-03-23 2007-07-19 Michael Gertner Methods and devices for percutaneously modifying organs to treat patients
US7931580B2 (en) 2004-03-23 2011-04-26 Michael Gertner Methods and devices for percutaneously modifying organs to treat patients
US20050267533A1 (en) * 2004-03-23 2005-12-01 Michael Gertner Methods and devices for the surgical creation of satiety and biofeedback pathways
US20060074473A1 (en) * 2004-03-23 2006-04-06 Michael Gertner Methods and devices for combined gastric restriction and electrical stimulation
US20050228415A1 (en) * 2004-03-23 2005-10-13 Michael Gertner Methods and devices for percutaneous, non-laparoscopic treatment of obesity
US20060142790A1 (en) * 2004-03-23 2006-06-29 Michael Gertner Methods and devices to facilitate connections between body lumens
US8070673B2 (en) 2004-03-23 2011-12-06 Michael Gertner Devices and methods to treat a patient
US20100234682A1 (en) * 2004-03-23 2010-09-16 Michael Gertner Closed loop gastric restriction devices and methods
US20070233170A1 (en) * 2004-03-23 2007-10-04 Michael Gertner Extragastric Balloon
US20050216042A1 (en) * 2004-03-23 2005-09-29 Michael Gertner Percutaneous gastroplasty
US7963907B2 (en) 2004-03-23 2011-06-21 Michael Gertner Closed loop gastric restriction devices and methods
US7255675B2 (en) 2004-03-23 2007-08-14 Michael Gertner Devices and methods to treat a patient
US20060195139A1 (en) * 2004-03-23 2006-08-31 Michael Gertner Extragastric devices and methods for gastroplasty
US20050216040A1 (en) * 2004-03-23 2005-09-29 Michael Gertner Devices and methods to treat a patient
US7946976B2 (en) 2004-03-23 2011-05-24 Michael Gertner Methods and devices for the surgical creation of satiety and biofeedback pathways
US20070027358A1 (en) * 2004-03-23 2007-02-01 Michael Gertner Devices and methods to treat a patient
US20070173888A1 (en) * 2004-03-23 2007-07-26 Michael Gertner Methods and devices for percutaneously modifying organs to treat patients
US7670279B2 (en) 2004-03-23 2010-03-02 Michael Gertner Percutaneous gastroplasty
US20070179335A1 (en) * 2004-03-23 2007-08-02 Michael Gertner Methods and devices for percutaneously modifying organs to treat patients
US7753870B2 (en) 2004-03-26 2010-07-13 Satiety, Inc. Systems and methods for treating obesity
US10098773B2 (en) 2004-04-26 2018-10-16 Boston Scientific Scimed, Inc. Restrictive and/or obstructive implant for inducing weight loss
US8241202B2 (en) 2004-04-26 2012-08-14 Barosense, Inc. Restrictive and/or obstructive implant for inducing weight loss
US20090209984A1 (en) * 2004-05-07 2009-08-20 Usgi Medical, Inc. Methods for performing gastroplasty
US8236009B2 (en) 2004-05-07 2012-08-07 Usgi Medical, Inc. Needle assembly for tissue manipulation
US20060015125A1 (en) * 2004-05-07 2006-01-19 Paul Swain Devices and methods for gastric surgery
US7520884B2 (en) 2004-05-07 2009-04-21 Usgi Medical Inc. Methods for performing gastroplasty
US20050250980A1 (en) * 2004-05-07 2005-11-10 Usgi Medical Corp. Methods for performing gastroplasty
US8216252B2 (en) 2004-05-07 2012-07-10 Usgi Medical, Inc. Tissue manipulation and securement system
US8257394B2 (en) 2004-05-07 2012-09-04 Usgi Medical, Inc. Apparatus and methods for positioning and securing anchors
US8926634B2 (en) 2004-05-07 2015-01-06 Usgi Medical, Inc. Apparatus and methods for manipulating and securing tissue
US11045341B2 (en) 2004-05-07 2021-06-29 Usgi Medical, Inc. Apparatus for manipulating and securing tissue
US8828027B2 (en) 2004-05-07 2014-09-09 U.S.G.I. Medical, Inc. Tissue manipulation and securement system
US7736374B2 (en) 2004-05-07 2010-06-15 Usgi Medical, Inc. Tissue manipulation and securement system
US8444657B2 (en) 2004-05-07 2013-05-21 Usgi Medical, Inc. Apparatus and methods for rapid deployment of tissue anchors
US20050251158A1 (en) * 2004-05-07 2005-11-10 Usgi Medical Inc. Methods and apparatus for performing endoluminal gastroplasty
US7918869B2 (en) 2004-05-07 2011-04-05 Usgi Medical, Inc. Methods and apparatus for performing endoluminal gastroplasty
US8216253B2 (en) 2004-05-07 2012-07-10 Usgi Medical, Inc. Apparatus for manipulating and securing tissue
US20070239195A1 (en) * 2004-05-18 2007-10-11 Nocca David J Adjustable Prosthetic Band
US7803195B2 (en) 2004-06-03 2010-09-28 Mayo Foundation For Medical Education And Research Obesity treatment and device
US20050273060A1 (en) * 2004-06-03 2005-12-08 Mayo Foundation For Medical Education And Research Obesity treatment and device
US8911393B2 (en) 2004-06-03 2014-12-16 Mayo Foundation For Medical Education And Research Obesity treatment and device
US20110009980A1 (en) * 2004-06-03 2011-01-13 Mayo Foundation For Medical Education And Research Obesity treatment and device
US8372158B2 (en) 2004-06-03 2013-02-12 Enteromedics, Inc. Obesity treatment and device
US8573226B2 (en) 2004-06-14 2013-11-05 Usgi Medical, Inc. Apparatus and methods for performing transluminal gastrointestinal procedures
US20050277945A1 (en) * 2004-06-14 2005-12-15 Usgi Medical Inc. Apparatus and methods for performing transluminal gastrointestinal procedures
US7931661B2 (en) 2004-06-14 2011-04-26 Usgi Medical, Inc. Apparatus and methods for performing transluminal gastrointestinal procedures
US20110196392A1 (en) * 2004-06-14 2011-08-11 Usgi Medical, Inc. Apparatus and methods for performing transluminal gastrointestinal procedures
US20050288694A1 (en) * 2004-06-23 2005-12-29 Stepehen Solomon Adjustable percutaneous stomach lumen restriction device
US20050285604A1 (en) * 2004-06-29 2005-12-29 Ryoichi Shinohara Partial discharge detecting sensor and gas insulated electric apparatus provided with a partial discharge detecting sensor
US11357549B2 (en) 2004-07-02 2022-06-14 Nuvasive Specialized Orthopedics, Inc. Expandable rod system to treat scoliosis and method of using the same
US7837643B2 (en) 2004-07-09 2010-11-23 Gi Dynamics, Inc. Methods and devices for placing a gastrointestinal sleeve
US20060020277A1 (en) * 2004-07-20 2006-01-26 Gostout Christopher J Gastric reshaping devices and methods
US20060036267A1 (en) * 2004-08-11 2006-02-16 Usgi Medical Inc. Methods and apparatus for performing malabsorptive bypass procedures within a patient's gastro-intestinal lumen
US9149270B2 (en) 2004-08-27 2015-10-06 Davol, Inc. (a C.R. Bard Company) Endoscopic tissue apposition device and method of use
US20060047289A1 (en) * 2004-08-27 2006-03-02 Roberto Fogel Endoscopic tissue apposition device and method of use
US8172857B2 (en) 2004-08-27 2012-05-08 Davol, Inc. Endoscopic tissue apposition device and method of use
US7815591B2 (en) 2004-09-17 2010-10-19 Gi Dynamics, Inc. Atraumatic gastrointestinal anchor
US9642614B1 (en) 2004-09-20 2017-05-09 Endoevolution, Llc Apparatus and method for minimally invasive suturing
US10111654B2 (en) 2004-09-20 2018-10-30 Endoevolution, Llc Apparatus and method for minimally invasive suturing
US11172922B2 (en) 2004-09-20 2021-11-16 Intuitive Surgical Operations, Inc. Apparatus and method for minimally invasive suturing
US9451948B2 (en) 2004-09-20 2016-09-27 Endoevolution, Llc Apparatus and method for minimally invasive suturing
US7862572B2 (en) 2004-09-20 2011-01-04 Endoevolution, Llc Apparatus and method for minimally invasive suturing
US8123764B2 (en) 2004-09-20 2012-02-28 Endoevolution, Llc Apparatus and method for minimally invasive suturing
US9474523B2 (en) 2004-09-20 2016-10-25 Endoevolution, Llc Apparatus and method for minimally invasive suturing
US11253249B2 (en) 2004-09-20 2022-02-22 Intuitive Surgical Operations, Inc. Apparatus and method for minimally invasive suturing
US10098630B2 (en) 2004-09-20 2018-10-16 Endoevolution, Llc Apparatus and method for minimally invasive suturing
US9962153B2 (en) 2004-09-20 2018-05-08 Endoevolution, Llc Apparatus and method for minimally invasive suturing
US9962154B2 (en) 2004-09-20 2018-05-08 Endoevolution, Llc Apparatus and method for minimally invasive suturing
US9962155B2 (en) 2004-09-20 2018-05-08 Endoevolution, Llc Apparatus and method for minimally invasive suturing
US9936944B2 (en) 2004-09-20 2018-04-10 Endoevolution, Llc Apparatus and method for minimally invasive suturing
US9597071B1 (en) 2004-09-20 2017-03-21 Endoevolution, Llc Apparatus and method for minimally invasive suturing
US20060069396A1 (en) * 2004-09-20 2006-03-30 Suturtek Incorporated Apparatus and method for minimally invasive suturing
US9642613B1 (en) 2004-09-20 2017-05-09 Endoevolution, Llc Apparatus and method for minimally invasive suturing
US20100152751A1 (en) * 2004-09-20 2010-06-17 Endoevolution, Llc Apparatus and method for minimally invasive suturing
US9675339B2 (en) 2004-09-20 2017-06-13 Endoevolution, Llc Devices and methods for minimally invasive suturing
US9808238B2 (en) 2004-09-20 2017-11-07 Endoevolution, Llc Apparatus and method for minimally invasive suturing
US9795377B2 (en) 2004-09-20 2017-10-24 Endoevolution, Llc Apparatus and method for minimally invasive suturing
US9795376B2 (en) 2004-09-20 2017-10-24 Endoevolution, Llc Apparatus and method for minimally invasive suturing
US9700301B2 (en) 2004-09-20 2017-07-11 Endoevolution, Llc Suturing needles
US8821519B2 (en) 2004-09-20 2014-09-02 Endoevolution, Llc Apparatus and method for minimally invasive suturing
US9700302B2 (en) 2004-09-20 2017-07-11 Endoevolution, Llc Suturing needles
US20120053504A1 (en) * 2004-09-27 2012-03-01 Valentx, Inc. Methods for attachment of a gastrointestinal sleeve
US20060155375A1 (en) * 2004-09-27 2006-07-13 Jonathan Kagan Devices and methods for attachment of a gastrointestinal sleeve
US9198789B2 (en) 2004-10-15 2015-12-01 Bfkw, Llc Bariatric device and method
US9839545B2 (en) 2004-10-15 2017-12-12 Bfkw, Llc Bariatric device and method
US9055998B2 (en) 2004-10-15 2015-06-16 Bfkw, Llc Bariatric device and method for recipient with altered anatomy
US8100931B2 (en) 2004-10-15 2012-01-24 Bfkw, Llc Bariatric device and method
US8672831B2 (en) 2004-10-15 2014-03-18 Bfkw, Llc Bariatric device and method
US7846174B2 (en) 2004-10-15 2010-12-07 Bfkw, Llc Bariatric device and method
US9414948B2 (en) 2004-10-15 2016-08-16 Bfkw, Llc Bariatric device and method
US10792174B2 (en) 2004-10-15 2020-10-06 Bfkw, Llc Bariatric device and method
US20110092879A1 (en) * 2004-10-15 2011-04-21 Bfkw,Llc Bariatric device and method
US11642234B2 (en) 2004-10-15 2023-05-09 Bfkw, Llc Bariatric device and method
US20070293716A1 (en) * 2004-10-15 2007-12-20 Bfkw, Llc Bariatric device and method
US8801599B2 (en) 2004-10-15 2014-08-12 Bfkw, Llc Bariatric device and method
US8979895B2 (en) 2004-10-18 2015-03-17 Temple University—of the Commonwelth System of Higher Education Method and apparatus of endoscopic suturing
US20100036395A1 (en) * 2004-10-18 2010-02-11 Temple University Of The Commonwealth System Of Higher Education Method and apparatus of endoscopic suturing
US8070824B2 (en) 2004-10-26 2011-12-06 Baronova, Inc. Medical device delivery catheter
US20080215130A1 (en) * 2004-10-26 2008-09-04 Baronova, Inc. Medical device delivery catheter
US20060089627A1 (en) * 2004-10-26 2006-04-27 Polymorfix, Inc. Medical device delivery catheter
US7347868B2 (en) 2004-10-26 2008-03-25 Baronova, Inc. Medical device delivery catheter
US8579988B2 (en) 2004-10-26 2013-11-12 Baronova, Inc. Medical device delivery catheter
US8403839B2 (en) 2004-11-17 2013-03-26 Ethicon Endo-Surgery, Inc. Remote tissue retraction device
US8092378B2 (en) 2004-11-17 2012-01-10 Ethicon Endo-Surgery, Inc. Remote tissue retraction device
US8939902B2 (en) 2004-11-17 2015-01-27 Ethicon Endo-Surgery, Inc. Remote tissue retraction device
US8454503B2 (en) 2004-11-17 2013-06-04 Ethicon Endo-Surgery, Inc. Remote tissue retraction device
US8795166B2 (en) 2004-11-17 2014-08-05 Ethicon Endo-Surgery, Inc. Remote tissue retraction device
US8403838B2 (en) 2004-11-17 2013-03-26 Ethicon Endo-Surgery, Inc. Remote tissue retraction device
US8784306B2 (en) 2004-11-17 2014-07-22 Ethicon Endo-Surgery, Inc. Remote tissue retraction device
US20080161787A1 (en) * 2004-12-21 2008-07-03 Mitchell Roslin Anastomotic Outlet Revision
US8088132B2 (en) 2004-12-21 2012-01-03 Davol, Inc. (a C.R. Bard Company) Anastomotic outlet revision
US20080154289A1 (en) * 2004-12-21 2008-06-26 Davol Inc. Anastomotic outlet revision
US8087413B2 (en) * 2005-01-14 2012-01-03 Usgi Medical Inc. Attenuation of environmental parameters on a gastric lumen
US20060157067A1 (en) * 2005-01-14 2006-07-20 Usgi Medical Inc. Attenuation of environmental parameters on a gastric lumen
US20090222032A1 (en) * 2005-03-28 2009-09-03 Horndeski Gary M Device and method of weight control via indirect abdominal cavity volume reduction
US20060217757A1 (en) * 2005-03-28 2006-09-28 Horndeski Gary M Device and method of weight control via indirect abdominal cavity volume reduction
US20070233169A1 (en) * 2005-03-28 2007-10-04 Horndeski Gary M Device and Method of Weight Control Via Indirect Abdominal Cavity Volume Reduction
US20070185507A1 (en) * 2005-04-22 2007-08-09 Helmut Schreiber Surgical marker/connector and method of installation
US7931662B2 (en) 2005-04-22 2011-04-26 Helmut Schreiber Surgical marker/connector and method of installation
US7452364B2 (en) 2005-04-22 2008-11-18 Helmut Schreiber Surgical marker/connector
US8142453B2 (en) 2005-04-22 2012-03-27 Helmut Schreiber Method for marking and connecting tissue
US20060253153A1 (en) * 2005-04-22 2006-11-09 Helmut Schreiber Surgical marker/connector
US20080097490A1 (en) * 2005-04-22 2008-04-24 Helmut Schreiber Method for Marking and Connecting Tissue
US20060253126A1 (en) * 2005-05-04 2006-11-09 Bernard Medical, Llc Endoluminal suturing device and method
US20060253142A1 (en) * 2005-05-04 2006-11-09 Bernard Medical, Llc Endoluminal gastric ring and method
US7674271B2 (en) 2005-05-04 2010-03-09 InTailor Surgical, Inc. Endoluminal gastric ring and method
US20060282107A1 (en) * 2005-05-09 2006-12-14 Kiyoshi Hashiba Intragastric device for treating obesity
US20060276810A1 (en) * 2005-05-09 2006-12-07 Brian Kelleher Methods and apparatus for excising tissue and creating wall-to-wall adhesions from within an organ
US20080161717A1 (en) * 2005-05-10 2008-07-03 Michael Eric Gertner Obesity Treatment Systems
US20060264981A1 (en) * 2005-05-20 2006-11-23 Viola Frank J Gastric restrictor assembly and method of use
US7666180B2 (en) 2005-05-20 2010-02-23 Tyco Healthcare Group Lp Gastric restrictor assembly and method of use
US20100145472A1 (en) * 2005-05-20 2010-06-10 Tyco Healthcare Group Lp Gastric Restrictor Assembly And Method Of Use
US20060264982A1 (en) * 2005-05-20 2006-11-23 Viola Frank J Gastric restrictor assembly and method of use
US7691053B2 (en) 2005-05-20 2010-04-06 Tyco Healthcare Group Lp Gastric restrictor assembly and method of use
US8114010B2 (en) 2005-05-20 2012-02-14 Tyco Healthcare Group Lp Gastric restrictor assembly and method of use
US9585651B2 (en) 2005-05-26 2017-03-07 Usgi Medical, Inc. Methods and apparatus for securing and deploying tissue anchors
US8298291B2 (en) 2005-05-26 2012-10-30 Usgi Medical, Inc. Methods and apparatus for securing and deploying tissue anchors
US7976488B2 (en) 2005-06-08 2011-07-12 Gi Dynamics, Inc. Gastrointestinal anchor compliance
US8425451B2 (en) 2005-06-08 2013-04-23 Gi Dynamics, Inc. Gastrointestinal anchor compliance
US7967818B2 (en) 2005-06-10 2011-06-28 Cook Medical Technologies Llc Cautery catheter
US20060282089A1 (en) * 2005-06-13 2006-12-14 Ethicon Endo-Surgery, Inc. Endoscopic suturing device
US7828812B2 (en) 2005-06-13 2010-11-09 Ethicon Endo-Surgery, Inc. Surgical suturing apparatus with needle release system
US7833236B2 (en) 2005-06-13 2010-11-16 Ethicon Endo-Surgery, Inc. Surgical suturing apparatus with collapsible vacuum chamber
US20060282098A1 (en) * 2005-06-13 2006-12-14 Shelton Frederick E Iv Surgical suturing apparatus with detachable handle
US7615060B2 (en) 2005-06-13 2009-11-10 Ethicon-Endo Surgery, Inc. Endoscopic suturing device
US20060281970A1 (en) * 2005-06-13 2006-12-14 Stokes Michael J Attachment apparatus for coupling with an endoscope
US9545191B2 (en) 2005-06-13 2017-01-17 Ethicon Endo-Surgery, Inc. Method for suture lacing
US7846169B2 (en) 2005-06-13 2010-12-07 Ethicon Endo-Surgery, Inc. Adjustable vacuum chamber for a surgical suturing apparatus
US7766925B2 (en) 2005-06-13 2010-08-03 Ethicon Endo-Surgery, Inc. Surgical suturing apparatus
US20060282095A1 (en) * 2005-06-13 2006-12-14 Stokes Michael J Surgical suturing apparatus with collapsible vacuum chamber
US20060282099A1 (en) * 2005-06-13 2006-12-14 Stokes Michael J Method for suture lacing
US20060282094A1 (en) * 2005-06-13 2006-12-14 Stokes Michael J Surgical suturing apparatus
US8500756B2 (en) 2005-06-13 2013-08-06 Ethicon Endo. Surgery, Inc. Quick load mechanism for a surgical suturing apparatus
US8641728B2 (en) 2005-06-13 2014-02-04 Ethicon Endo-Surgery, Inc. Attachment apparatus for coupling with an endoscope
US20060282096A1 (en) * 2005-06-13 2006-12-14 Papa Christopher A Quick load mechanism for a surgical suturing apparatus
US20060282090A1 (en) * 2005-06-13 2006-12-14 Stokes Michael J Surgical suturing apparatus with needle release system
US20060282097A1 (en) * 2005-06-13 2006-12-14 Ortiz Mark S Surgical suturing apparatus with a non-visible spectrum sensing member
US7628796B2 (en) 2005-06-13 2009-12-08 Ethicon Endo-Surgery, Inc. Surgical suturing apparatus with anti-backup system
US7887554B2 (en) 2005-06-13 2011-02-15 Ethicon Endo-Surgery, Inc. Surgical suturing apparatus with needle position indicator
US7976553B2 (en) 2005-06-13 2011-07-12 Ethicon Endo-Surgery, Inc. Surgical suturing apparatus with detachable handle
US20060282091A1 (en) * 2005-06-13 2006-12-14 Shelton Frederick E Iv Adjustable vacuum chamber for a surgical suturing apparatus
US20060282092A1 (en) * 2005-06-13 2006-12-14 Stokes Michael J Surgical suturing apparatus with needle position indicator
US20060282093A1 (en) * 2005-06-13 2006-12-14 Shelton Frederick E Iv Surgical suturing apparatus with anti-backup system
US10456128B2 (en) 2005-06-13 2019-10-29 Ethicon Llc Method for suture lacing
US8641729B2 (en) * 2005-07-13 2014-02-04 Creighton University Systems and techniques for minimally invasive gastrointestinal procedures
US8906040B2 (en) 2005-07-13 2014-12-09 Creighton University Systems and techniques for minimally invasive gastrointestinal procedures
US20080275473A1 (en) * 2005-07-13 2008-11-06 Creighton University Systems and techniques for minimally invasive gastrointestinal procedures
US20070129735A1 (en) * 2005-07-13 2007-06-07 Filipi Charles J Systems and techniques for minimally invasive gastrointestinal procedures
US8029535B2 (en) 2005-08-05 2011-10-04 Ethicon Endo-Surgery, Inc. Fasteners for use with gastric restriction
US7779845B2 (en) 2005-08-05 2010-08-24 Ethicon Endo-Surgery, Inc. Method and apparatus for endoscopically performing gastric reduction surgery
US20070032807A1 (en) * 2005-08-05 2007-02-08 Ortiz Mark S Method and clamp for gastric reduction surgery
US20070032702A1 (en) * 2005-08-05 2007-02-08 Ortiz Mark S Method and apparatus for endoscopically performing gastric reduction surgery
US7896894B2 (en) 2005-08-05 2011-03-01 Ethicon Endo-Surgery, Inc. Apparatus for single pass gastric restriction
US8715294B2 (en) 2005-08-05 2014-05-06 Ethicon Endo-Surgery, Inc. Gastric instrument sleeve to prevent cross contamination of stomach content and provide fixation and repeatable path
US20070032800A1 (en) * 2005-08-05 2007-02-08 Ortiz Mark S Apparatus for single pass gastric restriction
US8029522B2 (en) 2005-08-05 2011-10-04 Ethicon Endo-Surgery, Inc. Method and apparatus for sealing a gastric opening
US20070078302A1 (en) * 2005-08-05 2007-04-05 Ortiz Mark S Method and apparatus for sealing a gastric opening
US20070032797A1 (en) * 2005-08-05 2007-02-08 Ortiz Mark S Single pass gastric restriction with a corkscrew style wall anchor
US8252006B2 (en) * 2005-08-05 2012-08-28 Ethicon Endo-Surgery, Inc. Single pass gastric restriction with a corkscrew style wall anchor
US20070032822A1 (en) * 2005-08-05 2007-02-08 Ortiz Mark S Fasteners for use with gastic restriction
US20070043380A1 (en) * 2005-08-05 2007-02-22 Ortiz Mark S Gastric instrument sleeve to prevent cross contamination of stomach content and provide fixation and repeatable path
US8147506B2 (en) * 2005-08-05 2012-04-03 Ethicon Endo-Surgery, Inc. Method and clamp for gastric reduction surgery
US20100137885A1 (en) * 2005-08-18 2010-06-03 Ortiz Mark S Method And Apparatus For Endoscopically Performing Gastric Reduction Surgery In A Single Pass
US20120118935A1 (en) * 2005-08-18 2012-05-17 Ortiz Mark S Method and apparatus for endoscopically performing gastric reduction surgery in a single pass
US20070043384A1 (en) * 2005-08-18 2007-02-22 Ortiz Mark S Method and apparatus for endoscopically performing gastric reduction surgery in a single pass
US7771440B2 (en) * 2005-08-18 2010-08-10 Ethicon Endo-Surgery, Inc. Method and apparatus for endoscopically performing gastric reduction surgery in a single pass
US20070055292A1 (en) * 2005-09-02 2007-03-08 Ortiz Mark S Method and apparatus for endoscopically performing gastric reduction surgery in a single step
AU2006203498B2 (en) * 2005-09-02 2012-06-28 Ethicon Endo-Surgery, Inc. Method and apparatus for endoscopically performing gastric reduction surgery in a single step
US7896890B2 (en) * 2005-09-02 2011-03-01 Ethicon Endo-Surgery, Inc. Method and apparatus for endoscopically performing gastric reduction surgery in a single step
CN1923150B (en) * 2005-09-02 2011-02-16 伊西康内外科公司 Method and apparatus for endoscopically performing gastric reduction surgery in a single step
US20070078296A1 (en) * 2005-10-03 2007-04-05 Sabri Mahmoud T Stomach belt for weight loss
US9055942B2 (en) 2005-10-03 2015-06-16 Boston Scienctific Scimed, Inc. Endoscopic plication devices and methods
US8469977B2 (en) 2005-10-03 2013-06-25 Barosense, Inc. Endoscopic plication device and method
US20100228272A1 (en) * 2005-10-03 2010-09-09 Balbierz Daniel J Endoscopic plication device and method
US10299796B2 (en) 2005-10-03 2019-05-28 Boston Scientific Scimed, Inc. Endoscopic plication devices and methods
US7490602B2 (en) 2005-10-03 2009-02-17 Mahmoud Talaat Sabri Stomach belt for weight loss
US20070219571A1 (en) * 2005-10-03 2007-09-20 Balbierz Daniel J Endoscopic plication devices and methods
US8337388B2 (en) 2005-10-24 2012-12-25 Gil Vardi System and method to restrict stomach size
US7798992B2 (en) 2005-11-04 2010-09-21 Ethicon Endo-Surgery, Inc. Lumen traversing device
US20070106302A1 (en) * 2005-11-04 2007-05-10 Ethicon Endo-Surgery, Inc Lumen traversing device
US20070114261A1 (en) * 2005-11-23 2007-05-24 Ethicon Endo-Surgery, Inc. Surgical stapler with a bendable end effector
US7651017B2 (en) 2005-11-23 2010-01-26 Ethicon Endo-Surgery, Inc. Surgical stapler with a bendable end effector
US20070123917A1 (en) * 2005-11-29 2007-05-31 Ortiz Mark S Anastomotic device promoting tissue necrosis
WO2007067641A2 (en) * 2005-12-08 2007-06-14 Bernard Medical, Llc Endoluminal gastric ring and method
WO2007067641A3 (en) * 2005-12-08 2009-03-05 Bernard Medical Llc Endoluminal gastric ring and method
US20070142699A1 (en) * 2005-12-16 2007-06-21 Acoustx Corporation Methods and implantable apparatuses for treating an esophageal disorder such as gastroesophageal reflux disease
US20070142884A1 (en) * 2005-12-16 2007-06-21 Acoustx Corporation Methods and apparatuses for treating an esophageal disorder such as gastroesophageal reflux disease
US20070239284A1 (en) * 2005-12-22 2007-10-11 Skerven Gregory J Coiled intragastric member for treating obesity
US8216268B2 (en) 2005-12-22 2012-07-10 Cook Medical Technologies Llc Intragastric bag for treating obesity
US20070276428A1 (en) * 2005-12-22 2007-11-29 Haller Frederick B Intragastric bag for treating obesity
WO2007078988A2 (en) 2005-12-29 2007-07-12 Satiety, Inc. Devices and methods for placement of partitions within a hollow body organ
EP2382926A1 (en) 2005-12-29 2011-11-02 Ethicon Endo-Surgery, Inc. Devices for placement of partitions within a hollow body organ
EP2382927A1 (en) 2005-12-29 2011-11-02 Ethicon Endo-Surgery, Inc. Devices for placement of partitions within a hollow body organ
US10307155B2 (en) 2006-01-27 2019-06-04 Endoevolution, Llc Apparatus and method for tissue closure
US20090024145A1 (en) * 2006-01-27 2009-01-22 Meade John C Apparatus and method for sternotomy closure
US10383622B2 (en) 2006-01-27 2019-08-20 Endoevolution, Llc Apparatus and method for tissue closure
US8469973B2 (en) 2006-01-27 2013-06-25 Endoevolution, Llc Apparatus and method for sternotomy closure
US11033262B2 (en) 2006-01-27 2021-06-15 Intuitive Surgical Operations, Inc. Apparatus and method for tissue closure
US9986997B2 (en) 2006-01-27 2018-06-05 Endoevolution, Llc Apparatus and method for tissue closure
US8726909B2 (en) 2006-01-27 2014-05-20 Usgi Medical, Inc. Methods and apparatus for revision of obesity procedures
US9962156B2 (en) 2006-01-27 2018-05-08 Endoevolution, Llc Suturing needle
US20070191871A1 (en) * 2006-02-10 2007-08-16 Endogastric Solutions, Inc. Transesophageal gastric reduction method and device for reducing the size of a previously formed gastric reduction pouch
US8221438B2 (en) 2006-02-17 2012-07-17 Ethicon Endo-Surgery, Inc. Lumen reduction methods and devices
US20070198034A1 (en) * 2006-02-17 2007-08-23 Ethicon Endo-Surgery, Inc. Lumen reduction methods and devices
US20070198032A1 (en) * 2006-02-22 2007-08-23 Ethicon Endo-Surgery, Inc. Methods and devices for fastener removal
US20070213745A1 (en) * 2006-03-09 2007-09-13 Olympus Medical Systems Corp. Ligating apparatus
WO2007105220A2 (en) * 2006-03-15 2007-09-20 Noam Calderon Amelioration of urinary incontinence in females
WO2007105220A3 (en) * 2006-03-15 2009-04-09 Noam Calderon Amelioration of urinary incontinence in females
US20070225556A1 (en) * 2006-03-23 2007-09-27 Ethicon Endo-Surgery, Inc. Disposable endoscope devices
US7615004B2 (en) 2006-03-30 2009-11-10 Ethicon Endo-Surgery, Inc. Endoscopic ancillary attachment devices
US20070233188A1 (en) * 2006-03-31 2007-10-04 Hunt John V Adhesives for use with suture system minimize tissue erosion
US20070239175A1 (en) * 2006-03-31 2007-10-11 Stokes Michael J Method for securing a suture
US7686831B2 (en) 2006-03-31 2010-03-30 Ethicon Endo-Surgery, Inc. Method for securing a suture
US8118820B2 (en) 2006-03-31 2012-02-21 Ethicon Endo-Surgery, Inc. Method for instrument insertion through a body orifice
US20070239206A1 (en) * 2006-03-31 2007-10-11 Shelton Frederick E Iv Suture with adhesive/sealant delivery mechanism
US7740646B2 (en) 2006-03-31 2010-06-22 Ethicon Endo-Surgery, Inc. Adhesives for use with suture system minimize tissue erosion
US20070239177A1 (en) * 2006-03-31 2007-10-11 Stokes Michael J Method for instrument insertion through a body orifice
US7763036B2 (en) 2006-03-31 2010-07-27 Ethicon Endo-Surgery, Inc. Endoscopic instrument with secondary vacuum source
US20070239176A1 (en) * 2006-03-31 2007-10-11 Stokes Michael J Endoscopic instrument with secondary vacuum source
US20070239179A1 (en) * 2006-03-31 2007-10-11 Ethicon Endo-Surgery, Inc. Compliant Gastroplasty: Devices And Methods
US20090036910A1 (en) * 2006-04-19 2009-02-05 Vibrynt, Inc. Devices and Methods for Treatment of Obesity
US8353925B2 (en) 2006-04-19 2013-01-15 Vibrynt, Inc. Devices and methods for treatment of obesity
US8360069B2 (en) 2006-04-19 2013-01-29 Vibrynt, Inc. Devices and methods for treatment of obesity
US8398668B2 (en) 2006-04-19 2013-03-19 Vibrynt, Inc. Devices and methods for treatment of obesity
US8356605B2 (en) 2006-04-19 2013-01-22 Vibrynt, Inc. Devices and methods for treatment of obesity
US8585733B2 (en) 2006-04-19 2013-11-19 Vibrynt, Inc Devices, tools and methods for performing minimally invasive abdominal surgical procedures
US8070768B2 (en) 2006-04-19 2011-12-06 Vibrynt, Inc. Devices and methods for treatment of obesity
US7976554B2 (en) 2006-04-19 2011-07-12 Vibrynt, Inc. Devices, tools and methods for performing minimally invasive abdominal surgical procedures
US20090287227A1 (en) * 2006-04-19 2009-11-19 Newell Matthew B Minimally invasive ,methods for implanting obesity treatment devices
US8187297B2 (en) 2006-04-19 2012-05-29 Vibsynt, Inc. Devices and methods for treatment of obesity
US20080262523A1 (en) * 2006-04-19 2008-10-23 Joshua Makower Devices and methods for treatment of obesity
US20080262520A1 (en) * 2006-04-19 2008-10-23 Joshua Makower Devices and methods for treatment of obesity
US20090272388A1 (en) * 2006-04-19 2009-11-05 Shuji Uemura Minimally-invasive methods for implanting obesity treatment devices
US8001974B2 (en) 2006-04-19 2011-08-23 Vibrynt, Inc. Devices and methods for treatment of obesity
US8342183B2 (en) 2006-04-19 2013-01-01 Vibrynt, Inc. Devices and methods for treatment of obesity
US20090012554A1 (en) * 2006-04-19 2009-01-08 Joshua Makower Devices and methods for treatment of obesity
US20090012555A1 (en) * 2006-04-19 2009-01-08 Joshua Makower Devices and methods for treatment of obesity
US8460321B2 (en) 2006-04-19 2013-06-11 Vibrynt, Inc. Devices, tools and methods for performing minimally invasive abdominal surgical procedures
US20090281377A1 (en) * 2006-04-19 2009-11-12 Newell Matthew B Devices, tools and methods for performing minimally invasive abdominal surgical procedures
US20080255602A1 (en) * 2006-04-19 2008-10-16 Joshua Makower Devices and methods for treatment of obesity
US20090281498A1 (en) * 2006-04-19 2009-11-12 Acosta Pablo G Devices, system and methods for minimally invasive abdominal surgical procedures
US7881797B2 (en) 2006-04-25 2011-02-01 Valentx, Inc. Methods and devices for gastrointestinal stimulation
US20080058887A1 (en) * 2006-04-25 2008-03-06 Bobby Griffin Methods and devices for gastrointestinal stimulation
US8435262B2 (en) 2006-05-02 2013-05-07 Ethicon Endo-Surgery, Inc. Suture management
US20110077671A1 (en) * 2006-05-02 2011-03-31 Ethicon Endo-Surgery, Inc. Suture management
US20080097483A1 (en) * 2006-05-02 2008-04-24 Ethicon Endo-Surgery, Inc. Suture management
US7862582B2 (en) 2006-05-02 2011-01-04 Ethicon Endo-Surgery, Inc. Suture management
US7635373B2 (en) 2006-05-25 2009-12-22 Ethicon Endo-Surgery, Inc. Absorbable gastric restriction devices and methods
US20070276409A1 (en) * 2006-05-25 2007-11-29 Ethicon Endo-Surgery, Inc. Endoscopic gastric restriction methods and devices
US20070276411A1 (en) * 2006-05-25 2007-11-29 Ethicon Endo-Surgery, Inc. Absorbable Gastric Restriction Devices and Methods
US20090281568A1 (en) * 2006-06-14 2009-11-12 Juan Carlos Cendan Devices and Methods for Adjustable, Knotless Tissue Approximation
US8870916B2 (en) 2006-07-07 2014-10-28 USGI Medical, Inc Low profile tissue anchors, tissue anchor systems, and methods for their delivery and use
US20080097510A1 (en) * 2006-09-01 2008-04-24 Albrecht Thomas E Method for inducing weight loss with a patient
US20080058840A1 (en) * 2006-09-01 2008-03-06 Albrecht Thomas E Implantable coil for insertion into a hollow body organ
US10350099B2 (en) 2006-09-01 2019-07-16 Ethicon Endo-Surgery, Inc. Devices and methods for anchoring an endoluminal sleeve in the GI tract
US20080195226A1 (en) * 2006-09-02 2008-08-14 Williams Michael S Intestinal sleeves and associated deployment systems and methods
US9687334B2 (en) 2006-09-02 2017-06-27 Boston Scientific Scimed, Inc. Intestinal sleeves and associated deployment systems and methods
US8109895B2 (en) 2006-09-02 2012-02-07 Barosense, Inc. Intestinal sleeves and associated deployment systems and methods
US9314361B2 (en) 2006-09-15 2016-04-19 Boston Scientific Scimed, Inc. System and method for anchoring stomach implant
US20080089933A1 (en) * 2006-10-16 2008-04-17 Amir Alon Device and method for reducing calorie intake
US20080097496A1 (en) * 2006-10-20 2008-04-24 Arvin Chang System and method for securing an implantable interface to a mammal
US10039661B2 (en) 2006-10-20 2018-08-07 Nuvasive Specialized Orthopedics, Inc. Adjustable implant and method of use
US20080097487A1 (en) * 2006-10-20 2008-04-24 Scott Pool Method and apparatus for adjusting a gastrointestinal restriction device
US9526650B2 (en) 2006-10-20 2016-12-27 Nuvasive Specialized Orthopedics, Inc. Adjustable implant and method of use
US20080147112A1 (en) * 2006-10-20 2008-06-19 John Wesley Sheets Stomach invagination method and apparatus
US8808163B2 (en) 2006-10-20 2014-08-19 Ellipse Technologies, Inc. Adjustable implant and method of use
US20090062825A1 (en) * 2006-10-20 2009-03-05 Scott Pool Adjustable implant and method of use
US7981025B2 (en) 2006-10-20 2011-07-19 Ellipse Technologies, Inc. Adjustable implant and method of use
US11672684B2 (en) 2006-10-20 2023-06-13 Nuvasive Specialized Orthopedics, Inc. Adjustable implant and method of use
US11234849B2 (en) 2006-10-20 2022-02-01 Nuvasive Specialized Orthopedics, Inc. Adjustable implant and method of use
US9271857B2 (en) 2006-10-20 2016-03-01 Ellipse Technologies, Inc. Adjustable implant and method of use
US7862502B2 (en) 2006-10-20 2011-01-04 Ellipse Technologies, Inc. Method and apparatus for adjusting a gastrointestinal restriction device
US8246533B2 (en) 2006-10-20 2012-08-21 Ellipse Technologies, Inc. Implant system with resonant-driven actuator
US7749235B2 (en) * 2006-10-20 2010-07-06 Ethicon Endo-Surgery, Inc. Stomach invagination method and apparatus
US8715159B2 (en) 2006-10-20 2014-05-06 Ellipse Technologies, Inc. Adjustable implant and method of use
US20090062820A1 (en) * 2006-10-26 2009-03-05 Hourglass Technologies, Inc. Methods and devices for treating obesity and gerd by intussuscepting a portion of stomach tissue
US8257374B2 (en) 2006-10-26 2012-09-04 Hourglass Technologies, Inc. Methods and devices for treating obesity and GERD by intussuscepting a portion of stomach tissue
US20080255592A1 (en) * 2006-10-26 2008-10-16 Hourglass Technologies, Inc. Methods and devices for treating obesity and gerd by intussuscepting a portion of stomach tissue
US8100925B2 (en) 2006-10-26 2012-01-24 Hourglass Technologies, Inc. Methods and devices for treating obesity and GERD by intussuscepting a portion of stomach tissue
US8083758B2 (en) 2006-10-26 2011-12-27 Hourglass Technologies, Inc. Methods and devices for treating obesity and GERD by intussuscepting a portion of stomach tissue
US20090192531A1 (en) * 2006-10-26 2009-07-30 Hourglass Technologies, Inc. Methods and devices for treating obesity and gerd by intussuscepting a portion of stomach tissue
US20080125797A1 (en) * 2006-11-27 2008-05-29 Brian Kelleher Methods and Devices for Organ Partitioning
US8647353B2 (en) * 2006-12-28 2014-02-11 Olympus Medical Systems Corp. Endoscopic treatment tool and suturing method using the same
US20080262515A1 (en) * 2006-12-28 2008-10-23 Joshua Makower Devices and methods for treatment of obesity
US20080242933A1 (en) * 2006-12-28 2008-10-02 Olympus Medical Systems Corp. Endoscopic treatment tool and suturing method using the same
EP2380502A1 (en) 2006-12-29 2011-10-26 Ethicon Endo-Surgery, Inc. Devices and methods for placement of partitions within a hollow body organ
EP2380503A1 (en) 2006-12-29 2011-10-26 Ethicon Endo-Surgery, Inc. Devices and methods for placement of partitions within a hollow body organ
WO2008085994A2 (en) * 2007-01-08 2008-07-17 Endogastric Solutions Connected fasteners, delivery device and method
WO2008085994A3 (en) * 2007-01-08 2008-09-18 Endogastric Solutions Connected fasteners, delivery device and method
US20100324572A1 (en) * 2007-02-06 2010-12-23 The Ohio State University Research Foundation Endolumenal Restriction Method and Apparatus
US8591533B2 (en) * 2007-02-06 2013-11-26 The Ohio State University Research Foundation Endolumenal restriction method and apparatus
US8894670B2 (en) 2007-02-14 2014-11-25 Bfkw, Llc Mucosal capture fixation of medical device
US10786380B2 (en) 2007-02-14 2020-09-29 Bfkw, Llc Bariatric device and method
US20100030017A1 (en) * 2007-02-14 2010-02-04 Bkfw,Llc Bariatric device and method
US20100198237A1 (en) * 2007-02-14 2010-08-05 Sentinel Group, Llc Mucosal capture fixation of medical device
US11504255B2 (en) 2007-02-14 2022-11-22 Bfkw, Llc Bariatric device and method
US9872787B2 (en) 2007-02-14 2018-01-23 Bfkw, Llc Bariatric device and method
US8529431B2 (en) 2007-02-14 2013-09-10 Bfkw, Llc Bariatric device and method
US10687933B2 (en) 2007-02-14 2020-06-23 Bfkw, Llc Mucosal capture fixation of medical device
US8801647B2 (en) 2007-02-22 2014-08-12 Gi Dynamics, Inc. Use of a gastrointestinal sleeve to treat bariatric surgery fistulas and leaks
US20080319455A1 (en) * 2007-03-13 2008-12-25 Harris Peter S Methods and devices for reducing gastric volume
US20080249566A1 (en) * 2007-03-13 2008-10-09 Harris Peter S Methods and devices for reducing gastric volume
US20110066167A1 (en) * 2007-03-13 2011-03-17 Longevity Surgical, Inc. Devices and systems for manipulating tissue
US8142450B2 (en) 2007-03-13 2012-03-27 Longevity Surgical, Inc. Methods for reducing gastric volume
US8500777B2 (en) 2007-03-13 2013-08-06 Longevity Surgical, Inc. Methods for approximation and fastening of soft tissue
US8920437B2 (en) 2007-03-13 2014-12-30 Longevity Surgical, Inc. Devices for reconfiguring a portion of the gastrointestinal tract
US8100921B2 (en) 2007-03-13 2012-01-24 Longevity Surgical, Inc. Methods for reducing gastric volume
US9521995B2 (en) 2007-03-13 2016-12-20 Longevity Surgical, Inc. Devices and systems for approximation and fastening of soft tissue
US8057490B2 (en) 2007-03-13 2011-11-15 Longevity Surgical, Inc. Devices and systems for manipulating tissue
US8414600B2 (en) 2007-03-13 2013-04-09 Peter S. HARRIS Methods and devices for reducing gastric volume
US8469972B2 (en) 2007-03-13 2013-06-25 Longevity Surgical, Inc. Methods and devices for reducing gastric volume
US20090318936A1 (en) * 2007-03-13 2009-12-24 Longevity Surgical, Inc. Methods, devices and systems for approximation and fastening of soft tissue
US20110009887A1 (en) * 2007-03-13 2011-01-13 Longevity Surgical, Inc. Methods for reducing gastric volume
US8979872B2 (en) 2007-03-13 2015-03-17 Longevity Surgical, Inc. Devices for engaging, approximating and fastening tissue
US9707124B2 (en) 2007-03-19 2017-07-18 Hologic, Inc. Methods and apparatus for occlusion of body lumens
US8443808B2 (en) 2007-03-19 2013-05-21 Hologic, Inc. Methods and apparatus for occlusion of body lumens
US8851077B2 (en) 2007-03-19 2014-10-07 Hologic, Inc. Methods and apparatus for occlusion of body lumens
US8852216B2 (en) 2007-03-23 2014-10-07 Ethicon Endo-Surgery, Inc. Tissue approximation methods
US20080249561A1 (en) * 2007-04-04 2008-10-09 Stokes Michael J Method for plicating and fastening gastric tissue
US20080249539A1 (en) * 2007-04-04 2008-10-09 Stokes Michael J Device for plicating and fastening gastric tissue
US20080249541A1 (en) * 2007-04-04 2008-10-09 Stokes Michael J Device for plicating and fastening gastric tissue
US7951159B2 (en) 2007-04-04 2011-05-31 Ethicon Endo-Surgery, Inc. Method for plicating and fastening gastric tissue
US20080249540A1 (en) * 2007-04-04 2008-10-09 Stokes Michael J Method for plicating and fastening gastric tissue
US20080249542A1 (en) * 2007-04-04 2008-10-09 Stokes Michael J Device for plicating and fastening gastric tissue
US7722628B2 (en) 2007-04-04 2010-05-25 Ethicon Endo-Surgery, Inc. Device for plicating and fastening gastric tissue
US7799040B2 (en) 2007-04-04 2010-09-21 Ethicon Endo-Surgery, Inc. Device for plicating and fastening gastric tissue
US7803165B2 (en) 2007-04-04 2010-09-28 Ethicon Endo-Surgery, Inc. Device for plicating and fastening gastric tissue
US20080249560A1 (en) * 2007-04-04 2008-10-09 Stokes Michael J Method for plicating and fastening gastric tissue
US7803166B2 (en) 2007-04-04 2010-09-28 Ethicon Endo-Surgery, Inc. Method for plicating and fastening gastric tissue
US7815653B2 (en) 2007-04-04 2010-10-19 Ethicon Endo-Surgery, Inc. Method for plicating and fastening gastric tissue
US8641711B2 (en) 2007-05-04 2014-02-04 Covidien Lp Method and apparatus for gastrointestinal tract ablation for treatment of obesity
US9993281B2 (en) 2007-05-04 2018-06-12 Covidien Lp Method and apparatus for gastrointestinal tract ablation for treatment of obesity
US8007507B2 (en) 2007-05-10 2011-08-30 Cook Medical Technologies Llc Intragastric bag apparatus and method of delivery for treating obesity
US20080281257A1 (en) * 2007-05-10 2008-11-13 Waller David F Intragastric bag apparatus and method of delivery for treating obesity
US20100318015A1 (en) * 2007-05-29 2010-12-16 Kassab Ghassan S Devices, systems, and methods for achieving magnetic gastric bypass
US8506516B2 (en) * 2007-05-29 2013-08-13 Cvdevices, Llc Devices, systems, and methods for achieving magnetic gastric bypass
US20090012544A1 (en) * 2007-06-08 2009-01-08 Valen Tx, Inc. Gastrointestinal bypass sleeve as an adjunct to bariatric surgery
US8182441B2 (en) 2007-06-08 2012-05-22 Valentx, Inc. Methods and devices for intragastric support of functional or prosthetic gastrointestinal devices
US20090012553A1 (en) * 2007-06-08 2009-01-08 Valentx, Inc. Methods and devices for intragastric support of functional or prosthetic gastrointestinal devices
US20090012356A1 (en) * 2007-06-11 2009-01-08 Valen Tx, Inc. Endoscopic delivery devices and methods
US20080319470A1 (en) * 2007-06-20 2008-12-25 Viola Frank J Gastric restrictor assembly and method of use
US8435203B2 (en) 2007-06-20 2013-05-07 Covidien Lp Gastric restrictor assembly and method of use
US8790290B2 (en) 2007-06-20 2014-07-29 Covidien Lp Gastric restrictor assembly and method of use
CN101327140B (en) * 2007-06-22 2012-01-04 伊西康内外科公司 Surgical stapling instrument with a return mechanism
US10537456B2 (en) 2007-07-18 2020-01-21 Boston Scientific Scimed, Inc. Endoscopic implant system and method
US9456825B2 (en) 2007-07-18 2016-10-04 Boston Scientific Scimed, Inc. Endoscopic implant system and method
US20090024143A1 (en) * 2007-07-18 2009-01-22 Crews Samuel T Endoscopic implant system and method
US20090030284A1 (en) * 2007-07-18 2009-01-29 David Cole Overtube introducer for use in endoscopic bariatric surgery
US9545249B2 (en) 2007-07-18 2017-01-17 Boston Scientific Scimed, Inc. Overtube introducer for use in endoscopic bariatric surgery
US10166133B2 (en) 2007-09-07 2019-01-01 Baronova, Inc. Device for intermittently obstructing a gastric opening
US8795301B2 (en) 2007-09-07 2014-08-05 Baronova, Inc. Device for intermittently obstructing a gastric opening and method of use
US20090182358A1 (en) * 2007-09-07 2009-07-16 Baronova.Inc. Device for intermittently obstructing a gastric opening and method of use
US20090198210A1 (en) * 2007-09-07 2009-08-06 Baronova, Inc. Device for intermittently obstructing a gastric opening and method of use
US8888797B2 (en) 2007-09-07 2014-11-18 Baronova, Inc. Device for intermittently obstructing a gastric opening and method of use
US8821584B2 (en) 2007-09-07 2014-09-02 Baronova, Inc. Device for intermittently obstructing a gastric opening and method of use
US10736763B2 (en) 2007-09-07 2020-08-11 Baronova, Inc. Device for intermittently obstructing a gastric opening
US20090182357A1 (en) * 2007-09-07 2009-07-16 Baronova, Inc. Device for intermittently obstructing a gastric opening and method of use
US9504591B2 (en) 2007-09-07 2016-11-29 Baronova, Inc. Device for intermittently obstructing a gastric opening and method of use
US20090099588A1 (en) * 2007-10-11 2009-04-16 Joshua Makower Devices and methods for treatment of obesity
US8556925B2 (en) 2007-10-11 2013-10-15 Vibrynt, Inc. Devices and methods for treatment of obesity
US10349995B2 (en) 2007-10-30 2019-07-16 Nuvasive Specialized Orthopedics, Inc. Skeletal manipulation method
US11172972B2 (en) 2007-10-30 2021-11-16 Nuvasive Specialized Orthopedics, Inc. Skeletal manipulation method
US10376262B2 (en) 2007-10-31 2019-08-13 Covidien Lp Powered surgical instrument
US8496684B2 (en) 2007-10-31 2013-07-30 Ethicon Endo-Surgery, Inc. Method for deploying a device for gastric volume reduction
US9241712B2 (en) 2007-10-31 2016-01-26 Covidien Lp Powered surgical instrument
US7922063B2 (en) 2007-10-31 2011-04-12 Tyco Healthcare Group, Lp Powered surgical instrument
US9113876B2 (en) 2007-10-31 2015-08-25 Covidien Lp Powered surgical instrument
US9668731B2 (en) 2007-10-31 2017-06-06 Covidien Lp Powered surgical instrument
US8925783B2 (en) 2007-10-31 2015-01-06 Covidien Lp Powered surgical instrument
US8201721B2 (en) 2007-10-31 2012-06-19 Tyco Healthcare Group Lp Powered surgical instrument
US11246589B2 (en) 2007-10-31 2022-02-15 Covidien Lp Powered surgical instrument
US20090112232A1 (en) * 2007-10-31 2009-04-30 Lawrence Crainich Method for Deploying A Device For Gastric Volume Reduction
US20090118762A1 (en) * 2007-10-31 2009-05-07 Lawrence Crainch Disposable cartridge for use in a gastric volume reduction procedure
US20090149879A1 (en) * 2007-12-10 2009-06-11 Dillon Travis E Dynamic volume displacement weight loss device
US7883524B2 (en) 2007-12-21 2011-02-08 Wilson-Cook Medical Inc. Method of delivering an intragastric device for treating obesity
US20090164028A1 (en) * 2007-12-21 2009-06-25 Wilson-Cook Medical Inc. Method of delivering an intragastric device for treating obesity
US20090171382A1 (en) * 2007-12-27 2009-07-02 Wilson-Cook Medical Inc. Delivery system and method of delivery for treating obesity
US8016851B2 (en) 2007-12-27 2011-09-13 Cook Medical Technologies Llc Delivery system and method of delivery for treating obesity
US8945167B2 (en) 2007-12-31 2015-02-03 Boston Scientific Scimed, Inc. Gastric space occupier systems and methods of use
US20170165092A1 (en) * 2008-01-29 2017-06-15 Forsell Peter Method and instrument for treating obesity
US11666469B2 (en) * 2008-01-29 2023-06-06 Peter Forsell Method and instrument for treating obesity
US10449076B2 (en) * 2008-01-29 2019-10-22 Forsell Peter Method and instrument for treating obesity
US9301826B2 (en) 2008-02-18 2016-04-05 Covidien Lp Lock bar spring and clip for implant deployment device
US9044235B2 (en) 2008-02-18 2015-06-02 Covidien Lp Magnetic clip for implant deployment device
US10159554B2 (en) 2008-02-18 2018-12-25 Covidien Lp Clip for implant deployment device
US9398944B2 (en) 2008-02-18 2016-07-26 Covidien Lp Lock bar spring and clip for implant deployment device
US10695155B2 (en) 2008-02-18 2020-06-30 Covidien Lp Device and method for deploying and attaching an implant to a biological tissue
US9833240B2 (en) 2008-02-18 2017-12-05 Covidien Lp Lock bar spring and clip for implant deployment device
US9005241B2 (en) 2008-02-18 2015-04-14 Covidien Lp Means and method for reversibly connecting a patch to a patch deployment device
US10182898B2 (en) 2008-02-18 2019-01-22 Covidien Lp Clip for implant deployment device
US9034002B2 (en) 2008-02-18 2015-05-19 Covidien Lp Lock bar spring and clip for implant deployment device
US9107726B2 (en) 2008-02-18 2015-08-18 Covidien Lp Device and method for deploying and attaching an implant to a biological tissue
US9393093B2 (en) 2008-02-18 2016-07-19 Covidien Lp Clip for implant deployment device
US8808314B2 (en) 2008-02-18 2014-08-19 Covidien Lp Device and method for deploying and attaching an implant to a biological tissue
US9393002B2 (en) 2008-02-18 2016-07-19 Covidien Lp Clip for implant deployment device
US8317808B2 (en) 2008-02-18 2012-11-27 Covidien Lp Device and method for rolling and inserting a prosthetic patch into a body cavity
US8753359B2 (en) 2008-02-18 2014-06-17 Covidien Lp Device and method for deploying and attaching an implant to a biological tissue
US20090236394A1 (en) * 2008-03-18 2009-09-24 David Cole Endoscopic stapling devices and methods
US9636114B2 (en) 2008-03-18 2017-05-02 Boston Scientific Scimed, Inc. Endoscopic stapling devices
US7909219B2 (en) 2008-03-18 2011-03-22 Barosense, Inc. Endoscopic stapling devices and methods
US7913892B2 (en) 2008-03-18 2011-03-29 Barosense, Inc. Endoscopic stapling devices and methods
US7909223B2 (en) 2008-03-18 2011-03-22 Barosense, Inc. Endoscopic stapling devices and methods
US20090236392A1 (en) * 2008-03-18 2009-09-24 David Cole Endoscopic stapling devices and methods
US7922062B2 (en) 2008-03-18 2011-04-12 Barosense, Inc. Endoscopic stapling devices and methods
US7909222B2 (en) 2008-03-18 2011-03-22 Barosense, Inc. Endoscopic stapling devices and methods
US7708181B2 (en) 2008-03-18 2010-05-04 Barosense, Inc. Endoscopic stapling devices and methods
US8864008B2 (en) 2008-03-18 2014-10-21 Boston Scientific Scimed, Inc. Endoscopic stapling devices and methods
US7721932B2 (en) 2008-03-18 2010-05-25 Barosense, Inc. Endoscopic stapling devices and methods
US8020741B2 (en) 2008-03-18 2011-09-20 Barosense, Inc. Endoscopic stapling devices and methods
US20090255544A1 (en) * 2008-03-21 2009-10-15 Usgi Medical, Inc. Devices and methods for the endolumenal treatment of obesity
US11202707B2 (en) 2008-03-25 2021-12-21 Nuvasive Specialized Orthopedics, Inc. Adjustable implant system
US10076413B2 (en) 2008-03-25 2018-09-18 Nuvasive Specialized Orthopedics, Inc. Adjustable implant system
US9198755B2 (en) 2008-03-25 2015-12-01 Ellipse Technologies, Inc. Adjustable implant system
US20090275960A1 (en) * 2008-04-08 2009-11-05 John Mark Provenza Apparatus and method for gastric reduction
US8142385B2 (en) 2008-04-09 2012-03-27 E2 Llc Pyloric valve devices and methods
US20090259240A1 (en) * 2008-04-09 2009-10-15 Stryker Development Llc Pyloric valve
US8100850B2 (en) 2008-04-09 2012-01-24 E2 Llc Pyloric valve devices and methods
US20090259239A1 (en) * 2008-04-09 2009-10-15 Stryker Development Llc Pyloric valve devices and methods
US20090259237A1 (en) * 2008-04-09 2009-10-15 Stryker Development Llc Pyloric valve devices and methods
US20090259238A1 (en) * 2008-04-09 2009-10-15 Stryker Development Llc Pyloric valve devices and methods
US8579849B2 (en) 2008-04-09 2013-11-12 E2 Llc Pyloric valve devices and methods
US8182442B2 (en) 2008-04-09 2012-05-22 Electrocore Llc Pyloric valve devices and methods
US8226593B2 (en) 2008-04-09 2012-07-24 E2 Llc Pyloric valve
US8517972B2 (en) 2008-04-09 2013-08-27 E2 Llc Pyloric valve
US20090275942A1 (en) * 2008-05-01 2009-11-05 Ortiz Mark S Balloon tissue damage device
US20090275975A1 (en) * 2008-05-01 2009-11-05 Albrecht Thomas E Gastric coil manipulator
US20090275977A1 (en) * 2008-05-01 2009-11-05 Zeiner Mark S Tissue conveyor for use in gastric reduction surgery and associated method for use
US20090275937A1 (en) * 2008-05-01 2009-11-05 Stokes Michael J Method and apparatus for marking a lumenal wall
US20090275961A1 (en) * 2008-05-01 2009-11-05 Harris Jason L Gastric volume reduction using anterior to posterior wall junctions
US20090275980A1 (en) * 2008-05-01 2009-11-05 Zeiner Mark S Method and apparatus for the formation of tissue folds
US20090275957A1 (en) * 2008-05-01 2009-11-05 Harris Jason L Clip and delivery assembly used in forming a tissue fold
US20090276055A1 (en) * 2008-05-01 2009-11-05 Ethicon Endo-Surgery, Inc. Method for gastric volume reduction surgery
US20090275964A1 (en) * 2008-05-01 2009-11-05 Zeiner Mark S Method of rolling stomach tissue so as to maximize the contact surface area of a fold
US8147502B2 (en) 2008-05-01 2012-04-03 Ethicon Endo-Surgery, Inc. Gastric coil manipulator
US8133217B2 (en) 2008-05-01 2012-03-13 Ethicon Endo-Surgery, Inc. Method and apparatus for marking a lumenal wall
US10350050B2 (en) 2008-05-01 2019-07-16 Ethicon Endo-Surgery, Inc. Method for gastric volume reduction surgery
US7862581B2 (en) 2008-05-01 2011-01-04 Ethicon Endo-Surgery, Inc. Tissue conveyor for use in gastric reduction surgery and associated method for use
US8357156B2 (en) 2008-05-01 2013-01-22 Ethicon Endo-Surgery, Inc. Balloon tissue damage device
US7997468B2 (en) 2008-05-05 2011-08-16 Tyco Healthcare Group Lp Surgical instrument with clamp
US8256653B2 (en) 2008-05-05 2012-09-04 Tyco Healthcare Group Lp Surgical instrument with clamp
US20090326675A1 (en) * 2008-06-27 2009-12-31 Albrecht Thomas E Implantable device for the treatment of obesity
US8236022B2 (en) 2008-06-27 2012-08-07 Ethicon Endo-Surgery, Inc. Implantable device for the treatment of obesity
US7976555B2 (en) 2008-07-17 2011-07-12 Endoevolution, Llc Apparatus and method for minimally invasive suturing
US8888811B2 (en) 2008-10-20 2014-11-18 Covidien Lp Device and method for attaching an implant to biological tissue
US8747421B2 (en) 2008-11-10 2014-06-10 Boston Scientific Scimed, Inc. Multi-fire stapling systems and methods for delivering arrays of staples
US10368862B2 (en) 2008-11-10 2019-08-06 Boston Scientific Scimed, Inc. Multi-fire stapling methods
US11202627B2 (en) 2008-11-10 2021-12-21 Boston Scientific Scimed, Inc. Multi-fire stapling systems and methods for delivering arrays of staples
US9451956B2 (en) 2008-11-10 2016-09-27 Boston Scientific Scimed, Inc. Multi-fire stapling systems
US7934631B2 (en) 2008-11-10 2011-05-03 Barosense, Inc. Multi-fire stapling systems and methods for delivering arrays of staples
US10729470B2 (en) 2008-11-10 2020-08-04 Nuvasive Specialized Orthopedics, Inc. External adjustment device for distraction device
US8911346B2 (en) 2008-12-05 2014-12-16 Onclomed, Inc. Gastric restriction devices with fillable chambers and ablation means for treating obesity
US8357081B2 (en) 2008-12-05 2013-01-22 Onciomed, Inc. Method and apparatus for gastric restriction of the stomach to treat obesity
US20100145370A1 (en) * 2008-12-05 2010-06-10 Anteromed, Inc. Method and apparatus for gastric restriction of the stomach to treat obesity
US20100145324A1 (en) * 2008-12-05 2010-06-10 Raj Nihalani Gastric restriction devices with fillable chambers and ablation means for treating obesity
US20100160995A1 (en) * 2008-12-18 2010-06-24 Jerome Dargent Method for treating obesity
US8734473B2 (en) 2009-02-18 2014-05-27 Covidien Lp Device and method for rolling and inserting a prosthetic patch into a body cavity
US10517643B2 (en) 2009-02-23 2019-12-31 Nuvasive Specialized Orthopedics, Inc. Non-invasive adjustable distraction system
US20100249822A1 (en) * 2009-03-31 2010-09-30 Raj Nihalani Method and apparatus for treating obesity and controlling weight gain using adjustable intragastric devices
US20100249825A1 (en) * 2009-03-31 2010-09-30 Raj Nihalani Method and apparatus for treating obesity and controlling weight gain using self-expanding intragastric devices
US9055994B2 (en) 2009-03-31 2015-06-16 Onciomed, Inc. Method and apparatus for treating obesity and controlling weight gain using self-expanding intragastric devices
US8100932B2 (en) 2009-03-31 2012-01-24 Onciomed, Inc. Method and apparatus for treating obesity and controlling weight gain using self-expanding intragastric devices
USRE47902E1 (en) 2009-03-31 2020-03-17 Reshape Lifesciences, Inc. Method and apparatus for treating obesity and controlling weight gain using self-expanding intragastric devices
US8702641B2 (en) 2009-04-03 2014-04-22 Metamodix, Inc. Gastrointestinal prostheses having partial bypass configurations
US9278019B2 (en) 2009-04-03 2016-03-08 Metamodix, Inc Anchors and methods for intestinal bypass sleeves
US10322021B2 (en) 2009-04-03 2019-06-18 Metamodix, Inc. Delivery devices and methods for gastrointestinal implants
US20100256775A1 (en) * 2009-04-03 2010-10-07 Metamodix, Inc. Modular gastrointestinal prostheses
US9962278B2 (en) 2009-04-03 2018-05-08 Metamodix, Inc. Modular gastrointestinal prostheses
US9044300B2 (en) 2009-04-03 2015-06-02 Metamodix, Inc. Gastrointestinal prostheses
US9173760B2 (en) 2009-04-03 2015-11-03 Metamodix, Inc. Delivery devices and methods for gastrointestinal implants
US8211186B2 (en) 2009-04-03 2012-07-03 Metamodix, Inc. Modular gastrointestinal prostheses
US10478232B2 (en) 2009-04-29 2019-11-19 Nuvasive Specialized Orthopedics, Inc. Interspinous process device and method
US8961539B2 (en) 2009-05-04 2015-02-24 Boston Scientific Scimed, Inc. Endoscopic implant system and method
US20110009690A1 (en) * 2009-07-10 2011-01-13 Metamodix, Inc. External Anchoring Configurations for Modular Gastrointestinal Prostheses
US8282598B2 (en) 2009-07-10 2012-10-09 Metamodix, Inc. External anchoring configurations for modular gastrointestinal prostheses
US8702642B2 (en) 2009-07-10 2014-04-22 Metamodix, Inc. External anchoring configurations for modular gastrointestinal prostheses
US9999424B2 (en) 2009-08-17 2018-06-19 Covidien Lp Means and method for reversibly connecting an implant to a deployment device
US8906045B2 (en) 2009-08-17 2014-12-09 Covidien Lp Articulating patch deployment device and method of use
US20110098725A1 (en) * 2009-09-03 2011-04-28 Usgi Medical, Inc. Devices and methods for endolumenal weight loss treatments
US20110118650A1 (en) * 2009-11-18 2011-05-19 Anteromed, Inc. Method and apparatus for treating obesity and controlling weight gain and absorption of glucose in mammals
US20110288576A1 (en) * 2010-05-21 2011-11-24 Jason Lane Hoffman Hoffy Bougie Gastric Tube
WO2011146853A2 (en) 2010-05-21 2011-11-24 Barosense, Inc. Tissue-acquisition and fastening devices and methods
US10413436B2 (en) 2010-06-13 2019-09-17 W. L. Gore & Associates, Inc. Intragastric device for treating obesity
US10420665B2 (en) 2010-06-13 2019-09-24 W. L. Gore & Associates, Inc. Intragastric device for treating obesity
US11135078B2 (en) 2010-06-13 2021-10-05 Synerz Medical, Inc. Intragastric device for treating obesity
US11351050B2 (en) 2010-06-13 2022-06-07 Synerz Medical, Inc. Intragastric device for treating obesity
US9526648B2 (en) 2010-06-13 2016-12-27 Synerz Medical, Inc. Intragastric device for treating obesity
US10512557B2 (en) 2010-06-13 2019-12-24 W. L. Gore & Associates, Inc. Intragastric device for treating obesity
US11596538B2 (en) 2010-06-13 2023-03-07 Synerz Medical, Inc. Intragastric device for treating obesity
US11607329B2 (en) 2010-06-13 2023-03-21 Synerz Medical, Inc. Intragastric device for treating obesity
US10660675B2 (en) 2010-06-30 2020-05-26 Nuvasive Specialized Orthopedics, Inc. External adjustment device for distraction device
US10405891B2 (en) 2010-08-09 2019-09-10 Nuvasive Specialized Orthopedics, Inc. Maintenance feature in magnetic implant
US9962151B2 (en) 2010-10-01 2018-05-08 Endoevolution, Llc Devices and methods for minimally invasive suturing
US10792031B2 (en) 2010-10-01 2020-10-06 Intuitive Surgical Operations, Inc. Devices and methods for minimally invasive suturing
US10881392B2 (en) 2010-10-01 2021-01-05 Intuitive Surgical Operations, Inc. Devices and methods for minimally invasive suturing
US9775600B2 (en) 2010-10-01 2017-10-03 Endoevolution, Llc Devices and methods for minimally invasive suturing
US7993354B1 (en) 2010-10-01 2011-08-09 Endoevolution, Llc Devices and methods for minimally invasive suturing
US11471166B2 (en) * 2010-11-01 2022-10-18 Boston Scientific Scimed, Inc. Tissue closure
US20120109159A1 (en) * 2010-11-01 2012-05-03 Gary Jordan Tissue closure
US9451967B2 (en) * 2010-11-01 2016-09-27 Boston Scientific Scimed, Inc. Tissue closure
US10646262B2 (en) 2011-02-14 2020-05-12 Nuvasive Specialized Orthopedics, Inc. System and method for altering rotational alignment of bone sections
US9320715B2 (en) 2011-03-29 2016-04-26 Slendine Sa Devices and methods for weight control and weight loss
US11737901B2 (en) * 2011-04-04 2023-08-29 FreeHold Surgical, LLC Method for performing a gastrectomy
US11129703B2 (en) 2011-05-20 2021-09-28 Bfkw, Llc Intraluminal device and method of fixation
US9375338B2 (en) 2011-05-20 2016-06-28 Bfkw, Llc Intraluminal device and method with enhanced anti-migration
US10182901B2 (en) 2011-05-20 2019-01-22 Bfkw, Llc Intraluminal device and method of fixation
US10743794B2 (en) 2011-10-04 2020-08-18 Nuvasive Specialized Orthopedics, Inc. Devices and methods for non-invasive implant length sensing
US11123107B2 (en) 2011-11-01 2021-09-21 Nuvasive Specialized Orthopedics, Inc. Adjustable magnetic devices and methods of using same
US10349982B2 (en) 2011-11-01 2019-07-16 Nuvasive Specialized Orthopedics, Inc. Adjustable magnetic devices and methods of using same
US10016220B2 (en) 2011-11-01 2018-07-10 Nuvasive Specialized Orthopedics, Inc. Adjustable magnetic devices and methods of using same
US10219931B2 (en) 2011-11-09 2019-03-05 Easynotes Ltd. Obstruction device
US9113867B2 (en) 2011-12-15 2015-08-25 Ethicon Endo-Surgery, Inc. Devices and methods for endoluminal plication
US9113879B2 (en) 2011-12-15 2015-08-25 Ethicon Endo-Surgery, Inc. Devices and methods for endoluminal plication
US9113868B2 (en) 2011-12-15 2015-08-25 Ethicon Endo-Surgery, Inc. Devices and methods for endoluminal plication
US9119615B2 (en) 2011-12-15 2015-09-01 Ethicon Endo-Surgery, Inc. Devices and methods for endoluminal plication
US9113866B2 (en) 2011-12-15 2015-08-25 Ethicon Endo-Surgery, Inc. Devices and methods for endoluminal plication
US9173657B2 (en) 2011-12-15 2015-11-03 Ethicon Endo-Surgery, Inc. Devices and methods for endoluminal plication
US10687808B2 (en) 2011-12-15 2020-06-23 Ethicon Endo-Surgery, Inc. Devices and methods for endoluminal plication
US10292703B2 (en) 2011-12-15 2019-05-21 Ethicon Endo-Surgery, Inc. Devices and methods for endoluminal plication
US9155528B2 (en) 2012-01-08 2015-10-13 Vibrynt, Inc. Methods, instruments and devices for extragastic reduction of stomach volume
US8382775B1 (en) 2012-01-08 2013-02-26 Vibrynt, Inc. Methods, instruments and devices for extragastric reduction of stomach volume
US9314362B2 (en) 2012-01-08 2016-04-19 Vibrynt, Inc. Methods, instruments and devices for extragastric reduction of stomach volume
US10285838B2 (en) 2012-01-13 2019-05-14 Boston Scientific Scimed, Inc. Tissue-acquisition device and method
US9554797B2 (en) 2012-01-13 2017-01-31 Boston Scientific Scimed, Inc. Tissue-acquisition device and method
WO2013106752A1 (en) * 2012-01-13 2013-07-18 Barosense, Inc. Tissue-acquisition device and method
EP3552557A1 (en) 2012-01-13 2019-10-16 Boston Scientific Scimed Inc. Tissue-aquisition device
US9545326B2 (en) 2012-03-06 2017-01-17 Bfkw, Llc Intraluminal device delivery technique
US10595852B2 (en) 2012-03-21 2020-03-24 Ethicon Llc Methods and devices for creating tissue plications
US9980716B2 (en) 2012-03-21 2018-05-29 Ethicon Llc Methods and devices for creating tissue plications
US8992547B2 (en) 2012-03-21 2015-03-31 Ethicon Endo-Surgery, Inc. Methods and devices for creating tissue plications
US10441302B2 (en) 2012-04-17 2019-10-15 A-Base Korlatolt Felelossegu Tarsasag Manipulator for grasping tissue
US11633203B2 (en) 2012-04-17 2023-04-25 A-Base Korlatolt Felelossegu Tarsasag Manipulator for grasping tissue
US9610088B2 (en) 2012-04-17 2017-04-04 A-Base Korlatolt Felelossegu Tarsasag Manipulator for grasping tissue
US9265514B2 (en) 2012-04-17 2016-02-23 Miteas Ltd. Manipulator for grasping tissue
US10799233B2 (en) 2012-05-01 2020-10-13 Brigham And Women's Hospital, Inc. Suturing device for laparoscopic procedures
US11717283B2 (en) 2012-05-01 2023-08-08 The Brigham And Women's Hospital, Inc. Suturing device for laparoscopic procedures
US20130304091A1 (en) * 2012-05-11 2013-11-14 Ethicon, Inc. Applicator instruments having distal end caps for facilitating the accurate placement of surgical fasteners during open repair procedures
US9364228B2 (en) * 2012-05-11 2016-06-14 Ethicon, Llc Applicator instruments having distal end caps for facilitating the accurate placement of surgical fasteners during open repair procedures
US11696678B2 (en) 2012-05-11 2023-07-11 Ethicon, Inc. Applicator instruments with inverted handles and triggers, curved shafts, and visible orientation indicia
US9039649B2 (en) 2012-05-31 2015-05-26 Valentx, Inc. Devices and methods for gastrointestinal bypass
US8956318B2 (en) 2012-05-31 2015-02-17 Valentx, Inc. Devices and methods for gastrointestinal bypass
US9173759B2 (en) 2012-05-31 2015-11-03 Valentx, Inc. Devices and methods for gastrointestinal bypass
US9451960B2 (en) 2012-05-31 2016-09-27 Valentx, Inc. Devices and methods for gastrointestinal bypass
US9675489B2 (en) 2012-05-31 2017-06-13 Valentx, Inc. Devices and methods for gastrointestinal bypass
US9566181B2 (en) 2012-05-31 2017-02-14 Valentx, Inc. Devices and methods for gastrointestinal bypass
US9681975B2 (en) 2012-05-31 2017-06-20 Valentx, Inc. Devices and methods for gastrointestinal bypass
US9050168B2 (en) 2012-05-31 2015-06-09 Valentx, Inc. Devices and methods for gastrointestinal bypass
US11213330B2 (en) 2012-10-29 2022-01-04 Nuvasive Specialized Orthopedics, Inc. Adjustable devices for treating arthritis of the knee
US11191579B2 (en) 2012-10-29 2021-12-07 Nuvasive Specialized Orthopedics, Inc. Adjustable devices for treating arthritis of the knee
US10159699B2 (en) 2013-01-15 2018-12-25 Metamodix, Inc. System and method for affecting intestinal microbial flora
US11793839B2 (en) 2013-01-15 2023-10-24 Metamodix, Inc. System and method for affecting intestinal microbial flora
US9456916B2 (en) 2013-03-12 2016-10-04 Medibotics Llc Device for selectively reducing absorption of unhealthy food
US9011365B2 (en) 2013-03-12 2015-04-21 Medibotics Llc Adjustable gastrointestinal bifurcation (AGB) for reduced absorption of unhealthy food
US9067070B2 (en) 2013-03-12 2015-06-30 Medibotics Llc Dysgeusia-inducing neurostimulation for modifying consumption of a selected nutrient type
US9757264B2 (en) 2013-03-13 2017-09-12 Valentx, Inc. Devices and methods for gastrointestinal bypass
US10874538B2 (en) 2013-03-15 2020-12-29 Baronova, Inc. Locking gastric obstruction device and method of use
US10070981B2 (en) 2013-03-15 2018-09-11 Baronova, Inc. Locking gastric obstruction device and method of use
US9125660B2 (en) 2013-04-14 2015-09-08 Easynotes Ltd. Inflation and deflation of obstruction device
US9456917B2 (en) 2013-08-28 2016-10-04 Ethicon Endo-Surgery, Inc. Endoscopic transoral duodenal sleeve applier
US10307280B2 (en) 2013-08-28 2019-06-04 Ethicon Endo-Surgery, Inc. Endoscopic transoral duodenal sleeve applier
US10751094B2 (en) 2013-10-10 2020-08-25 Nuvasive Specialized Orthopedics, Inc. Adjustable spinal implant
US9918863B2 (en) 2013-11-13 2018-03-20 Covidien Lp Steerable gastric calibration tube
US9775735B2 (en) 2014-01-31 2017-10-03 Covidien Lp Gastric calibration tube
US10639184B2 (en) 2014-01-31 2020-05-05 Covidien Lp Gastric calibration tube
US10123896B2 (en) 2014-03-06 2018-11-13 Mayo Foundation For Medical Education And Research Apparatus and methods of inducing weight loss using blood flow control
US11246694B2 (en) 2014-04-28 2022-02-15 Nuvasive Specialized Orthopedics, Inc. System for informational magnetic feedback in adjustable implants
WO2016056016A1 (en) 2014-10-08 2016-04-14 Nitinotes Ltd. Endoluminal sleeve gastroplasty
US10271885B2 (en) 2014-12-26 2019-04-30 Nuvasive Specialized Orthopedics, Inc. Systems and methods for distraction
US11439449B2 (en) 2014-12-26 2022-09-13 Nuvasive Specialized Orthopedics, Inc. Systems and methods for distraction
US10271940B2 (en) 2014-12-29 2019-04-30 Bfkw, Llc Fixation of intraluminal device
US11013629B2 (en) 2014-12-29 2021-05-25 Bfkw, Llc Fixation of intraluminal device
US11020213B2 (en) 2014-12-29 2021-06-01 Bfkw, Llc Fixation of intraluminal device
US10682219B2 (en) 2014-12-29 2020-06-16 Bfkw, Llc Fixation of intraluminal device
US10238427B2 (en) 2015-02-19 2019-03-26 Nuvasive Specialized Orthopedics, Inc. Systems and methods for vertebral adjustment
US11612416B2 (en) 2015-02-19 2023-03-28 Nuvasive Specialized Orthopedics, Inc. Systems and methods for vertebral adjustment
US10617453B2 (en) 2015-10-16 2020-04-14 Nuvasive Specialized Orthopedics, Inc. Adjustable devices for treating arthritis of the knee
US10835290B2 (en) 2015-12-10 2020-11-17 Nuvasive Specialized Orthopedics, Inc. External adjustment device for distraction device
US10918425B2 (en) 2016-01-28 2021-02-16 Nuvasive Specialized Orthopedics, Inc. System and methods for bone transport
US20170252195A1 (en) 2016-03-03 2017-09-07 Metamodix, Inc. Pyloric anchors and methods for intestinal bypass sleeves
US10729573B2 (en) 2016-03-03 2020-08-04 Metamodix, Inc. Pyloric anchors and methods for intestinal bypass sleeves
US9622897B1 (en) 2016-03-03 2017-04-18 Metamodix, Inc. Pyloric anchors and methods for intestinal bypass sleeves
US10779980B2 (en) 2016-04-27 2020-09-22 Synerz Medical, Inc. Intragastric device for treating obesity
US11666470B2 (en) 2016-05-19 2023-06-06 Metamodix, Inc Pyloric anchor retrieval tools and methods
US10751209B2 (en) 2016-05-19 2020-08-25 Metamodix, Inc. Pyloric anchor retrieval tools and methods
US11406372B2 (en) 2016-12-23 2022-08-09 The Brigham And Women's Hospital, Inc. Systems and methods for suturing tissue
US10542968B2 (en) 2016-12-23 2020-01-28 Brigham And Women's Hospital, Inc. Systems and methods for suturing tissue
US11253250B2 (en) 2017-02-26 2022-02-22 Intuitive Surgical Operations, Inc. Apparatus and method for minimally invasive suturing
US10292698B2 (en) 2017-07-27 2019-05-21 Endoevolution, Llc Apparatus and method for minimally invasive suturing
US11039829B2 (en) 2017-07-27 2021-06-22 Intuitive Surgical Operations, Inc. Apparatus and method for minimally invasive suturing
WO2020144693A1 (en) 2019-01-09 2020-07-16 Nitinotes Ltd. Tissue manipulation with an endoluminal gastroplasty device

Also Published As

Publication number Publication date
US20070219570A1 (en) 2007-09-20
US20070250083A1 (en) 2007-10-25
US8123765B2 (en) 2012-02-28
US7909838B2 (en) 2011-03-22
US20070118158A1 (en) 2007-05-24
US8419755B2 (en) 2013-04-16
US7288101B2 (en) 2007-10-30
US8080025B2 (en) 2011-12-20
US20040024386A1 (en) 2004-02-05
US8080022B2 (en) 2011-12-20
US20070118159A1 (en) 2007-05-24
US8137367B2 (en) 2012-03-20
US20030120265A1 (en) 2003-06-26
US20130296899A1 (en) 2013-11-07
US20020183768A1 (en) 2002-12-05
US8613749B2 (en) 2013-12-24
US7510559B2 (en) 2009-03-31
US20070213748A1 (en) 2007-09-13
US20030109892A1 (en) 2003-06-12
US7862574B2 (en) 2011-01-04
US20110152899A1 (en) 2011-06-23
US20070213740A1 (en) 2007-09-13
US20040122452A1 (en) 2004-06-24
US8794243B2 (en) 2014-08-05
US7503922B2 (en) 2009-03-17
US8137366B2 (en) 2012-03-20
US20070167963A1 (en) 2007-07-19
US20070282349A1 (en) 2007-12-06
US20040122453A1 (en) 2004-06-24
US8075577B2 (en) 2011-12-13
US7288099B2 (en) 2007-10-30

Similar Documents

Publication Publication Date Title
US6558400B2 (en) Obesity treatment tools and methods
AU2002312174B2 (en) Obesity treatment tools and methods
AU2002312174A1 (en) Obesity treatment tools and methods

Legal Events

Date Code Title Description
AS Assignment

Owner name: SATIETY, INC., CALIFORNIA

Free format text: ASSIGNMENT OF ASSIGNORS INTEREST;ASSIGNORS:DEEM, MARK E.;SUTTON, DOUGLAS S.;GIFFORD, HANSON S. III;AND OTHERS;REEL/FRAME:012182/0200;SIGNING DATES FROM 20010814 TO 20010815

STCF Information on status: patent grant

Free format text: PATENTED CASE

FEPP Fee payment procedure

Free format text: PAT HOLDER CLAIMS SMALL ENTITY STATUS, ENTITY STATUS SET TO SMALL (ORIGINAL EVENT CODE: LTOS); ENTITY STATUS OF PATENT OWNER: LARGE ENTITY

FPAY Fee payment

Year of fee payment: 4

FEPP Fee payment procedure

Free format text: PAYOR NUMBER ASSIGNED (ORIGINAL EVENT CODE: ASPN); ENTITY STATUS OF PATENT OWNER: LARGE ENTITY

FPAY Fee payment

Year of fee payment: 8

AS Assignment

Owner name: ETHICON ENDO-SURGERY, INC., OHIO

Free format text: ASSIGNMENT OF ASSIGNORS INTEREST;ASSIGNOR:SATIETY, INC.;REEL/FRAME:026111/0957

Effective date: 20110218

FEPP Fee payment procedure

Free format text: PAT HOLDER NO LONGER CLAIMS SMALL ENTITY STATUS, ENTITY STATUS SET TO UNDISCOUNTED (ORIGINAL EVENT CODE: STOL); ENTITY STATUS OF PATENT OWNER: LARGE ENTITY

REFU Refund

Free format text: REFUND - PAYMENT OF MAINTENANCE FEE, 12TH YR, SMALL ENTITY (ORIGINAL EVENT CODE: R2553); ENTITY STATUS OF PATENT OWNER: LARGE ENTITY

Free format text: REFUND - PAYMENT OF MAINTENANCE FEE, 12TH YEAR, LARGE ENTITY (ORIGINAL EVENT CODE: R1553); ENTITY STATUS OF PATENT OWNER: LARGE ENTITY

FPAY Fee payment

Year of fee payment: 12

FPAY Fee payment

Year of fee payment: 12

SULP Surcharge for late payment

Year of fee payment: 11