US671804A - Coated pill, &c. - Google Patents

Coated pill, &c. Download PDF

Info

Publication number
US671804A
US671804A US18307A US1900018307A US671804A US 671804 A US671804 A US 671804A US 18307 A US18307 A US 18307A US 1900018307 A US1900018307 A US 1900018307A US 671804 A US671804 A US 671804A
Authority
US
United States
Prior art keywords
coating
pill
pepsin
pills
compound
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
US18307A
Inventor
Frederick H Metcalf
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Individual
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US73899399A external-priority patent/US650760A/en
Application filed by Individual filed Critical Individual
Priority to US18307A priority Critical patent/US671804A/en
Application granted granted Critical
Publication of US671804A publication Critical patent/US671804A/en
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Images

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/20Pills, tablets, discs, rods
    • A61K9/28Dragees; Coated pills or tablets, e.g. with film or compression coating
    • A61K9/2806Coating materials
    • A61K9/2833Organic macromolecular compounds
    • A61K9/2873Proteins, e.g. gelatin

Description

Patented Apr. 9, I90L n vantoz f regge f 4 0019/7 MQW N RIS PETERS CO.. PNDTGLITHD.. WAIMINGTON, D. L
(No Model) Wihwooe /l Vfg/f UNITED STATES FREDERICK H. METCALF,
PATENT OFFICE.
OF FRANKLIN, ILLINOIS.
COATED PILL, Sac.
SPECIFICATION formingpart of Letters Patent No. 671,804, dated April 9, 1901. Original application filed December 2, 1899, Serial No. 738,993. Divided and this application filed May 28, 1900. Serial fication.
This invention relates to improvements in coated pills, tablets, lozenges, and the like, and forms part of a divisional application filed December 2, 1899, Serial No. 738,993, allowed May 2, 1900, and patented under No. 650,760.
One object of this improvement is to mix with the coating used in the manufacture of coated pills a sulcient quantity of pepsin to quickly dissolve said coating and make the medicine which is incased more susceptible to the digestive organs when taken into the stomach.
A further object of the improvement is to mix a sufficient quantity of pepsin with the coating for pills when said coating consists primarily of gelatin so as to assist the stornach to quickly and readily digest the coating to permit the exposure of the incased medical compound to the digestive organs.
Many other objects and advantages will be apparent upon further description.
In the drawiri gs forming a part of this specification, Figure l is a sectional view of a pill, showing my improvement applied thereto. Fig. 2 is a similar view showing a modified form of my invention.
Referring to the drawings, the numeral 1 represents a pill as a whole, composed of any suitable medical compound 2 and provided with a coating 3. Mixed with the coating is a sufficient quantity of pepsin or other digestive agent 4.
In the manufacture of pills, tablets, or lozenges for certain reasons it is necessary to provide a coating. In some cases this coating is composed of a mixture which is not readily susceptible to the digestive organs of the stomach; and it is the purpose and objectY of this invention to introduce in its composition a sucient quantity of pepsin so asto enable the stomach to readily 'and quickly reduce the coating and expose the incased medical compound. The coatings for pills, as
(No model.)
before stated, are largely made up of a gelatinous substance, and it is well known this substance is exceedingly difficult to digest, and it not infrequently occurs that a gelatincoated pill absolutely refuses to be subjected to the digestive organs and juices of the stomach, and as a result the pill is taken without any curative result.
While I am aware that the coating of pills is largely gelatin, I am also aware of other substances being used equally as hard to digest and propose to mix pepsin with my coating solution used for pills.
The pepsin is applied to the pill, tablet, or lozenge preferably when the coating is ina liquid state. However, a separate compartment may be made, as disclosed in Fig. 2. In this modification the pepsin is contained between two layers of coating, the outer one of which is thinner than the inner, so much so as to not be a barrier to the juices.
In many cases I may apply enough pepsin to not only reduce the coating around the pill, but to coact with the compound incased within the coating and assist in its digestion.
Having thus described my invention, what I claim isl l. As a new article of manufacture, a pill, tablet or lozenge provided with a gelatinous coating, said coating having pepsin distributed throughout its composition to assist the digestion of said'coating and the rapid liberation of the compound forming the pill, whereby the juices of the stomach, may have immediate action on said compound, substantially as described.
2. As a new article of manufacture, a pill, tablet or lozenge, provided with a gelatinous coating having pepsin uniformly distributed throughout its composition to assist the digestion of said coating and the rapid liberation of the compound forming the pill, whereby the juices of the stomach may have immediate action on said compound, substantially as described.
In testimony whereof I have hereunto set my hand in the presence of two subscribing witnesses.
FREDERICK H. METOALF. Witnesses:
CHARLES A. BARNES, LENA C. ENGEL.
US18307A 1899-12-02 1900-05-28 Coated pill, &c. Expired - Lifetime US671804A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
US18307A US671804A (en) 1899-12-02 1900-05-28 Coated pill, &c.

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US73899399A US650760A (en) 1899-12-02 1899-12-02 Gelatin capsule.
US18307A US671804A (en) 1899-12-02 1900-05-28 Coated pill, &c.

Publications (1)

Publication Number Publication Date
US671804A true US671804A (en) 1901-04-09

Family

ID=2740357

Family Applications (1)

Application Number Title Priority Date Filing Date
US18307A Expired - Lifetime US671804A (en) 1899-12-02 1900-05-28 Coated pill, &c.

Country Status (1)

Country Link
US (1) US671804A (en)

Cited By (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3181998A (en) * 1960-08-12 1965-05-04 Joseph L Kanig Tablet disintegration
US3493652A (en) * 1962-09-14 1970-02-03 Charles W Hartman Controlled release medicament
US3943238A (en) * 1972-11-01 1976-03-09 Meija Seika Co., Ltd. Method for the preparation of medicinal capsules
US4261969A (en) * 1979-05-03 1981-04-14 World Health Organization Controlled drug release composition
US4820524A (en) * 1987-02-20 1989-04-11 Mcneilab, Inc. Gelatin coated caplets and process for making same
US4966771A (en) * 1987-02-20 1990-10-30 Mcneilab, Inc. Gelatin coated caplets and process for making same
US5314696A (en) * 1991-06-27 1994-05-24 Paulos Manley A Methods for making and administering a blinded oral dosage form and blinded oral dosage form therefor
US5750145A (en) * 1995-07-28 1998-05-12 Bristol-Myers Squibb Company Stable gelatin coated aspirin tablets
US20030059614A1 (en) * 1989-09-20 2003-03-27 Hani Sadek Enrobed core medicament

Cited By (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3181998A (en) * 1960-08-12 1965-05-04 Joseph L Kanig Tablet disintegration
US3493652A (en) * 1962-09-14 1970-02-03 Charles W Hartman Controlled release medicament
US3943238A (en) * 1972-11-01 1976-03-09 Meija Seika Co., Ltd. Method for the preparation of medicinal capsules
US4261969A (en) * 1979-05-03 1981-04-14 World Health Organization Controlled drug release composition
US4820524A (en) * 1987-02-20 1989-04-11 Mcneilab, Inc. Gelatin coated caplets and process for making same
US4966771A (en) * 1987-02-20 1990-10-30 Mcneilab, Inc. Gelatin coated caplets and process for making same
US5314537A (en) * 1987-02-20 1994-05-24 Mcneilab, Inc. Gelatin coated caplets and process for making same
US20030059614A1 (en) * 1989-09-20 2003-03-27 Hani Sadek Enrobed core medicament
US5314696A (en) * 1991-06-27 1994-05-24 Paulos Manley A Methods for making and administering a blinded oral dosage form and blinded oral dosage form therefor
US5558878A (en) * 1991-06-27 1996-09-24 Captab, L.L.C. Method for blinding a tableted medication
US5576019A (en) * 1991-06-27 1996-11-19 Captab 11C Method for blinding a medication
US5750145A (en) * 1995-07-28 1998-05-12 Bristol-Myers Squibb Company Stable gelatin coated aspirin tablets

Similar Documents

Publication Publication Date Title
US671804A (en) Coated pill, &c.
Allen et al. Corrosive injuries of the stomach
DK0632720T3 (en) Hydroxyethyl cellulose based depot dosage forms
US5576019A (en) Method for blinding a medication
DE59407288D1 (en) BUDESONIDE PELLETS WITH CONTROLLED RELEASE PROFILE AND METHOD FOR THEIR PRODUCTION
US650760A (en) Gelatin capsule.
Butte et al. Optimisation and in vivo evaluation of pectin based drug delivery system containing curcumin for colon
Park et al. Prediction and management of recurrent right colon diverticulitis
US2687367A (en) Medicinal tablet containing identification fragments
US1815902A (en) Device for administering medicaments
US2011587A (en) Coating for medical compound
US1863001A (en) Container for vending machine goods
Fenn et al. Misoprostol—a logical therapeutic approach to gastroduodenal mucosal injury induced by non‐steroidal anti‐inflammatory drugs?
Sheikh et al. Endoscopic evidence of mucosal injury in patients taking ticlopidine compared with patients taking aspirin/nonsteroidal antiinflammatory drugs and controls
JPH04193823A (en) Pill readily crushable with teeth and easily administrable without water
US2071511A (en) Enteric coating
US1021674A (en) Medicinal tablet.
US1746984A (en) Vehicle for acetyl-salicylic acid tablets
Kitamura et al. Tongue necrosis caused by systemic vascular diseases: A systematic review of the literature
US149679A (en) Improvement in medical compounds
Shandil et al. An autopsy based study of corrosive acid poisoning and its medico-legal aspects–
US1907203A (en) Coating for tablets, capsules, and pills
US54056A (en) Improved compound for the cure of dyspepsia
US209654A (en) Improvement in soluble coatings for pills
KR100204534B1 (en) Gold-coated oral refreshment pills and process for preparing thereof