US671804A - Coated pill, &c. - Google Patents
Coated pill, &c. Download PDFInfo
- Publication number
- US671804A US671804A US18307A US1900018307A US671804A US 671804 A US671804 A US 671804A US 18307 A US18307 A US 18307A US 1900018307 A US1900018307 A US 1900018307A US 671804 A US671804 A US 671804A
- Authority
- US
- United States
- Prior art keywords
- coating
- pill
- pepsin
- pills
- compound
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Images
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/28—Dragees; Coated pills or tablets, e.g. with film or compression coating
- A61K9/2806—Coating materials
- A61K9/2833—Organic macromolecular compounds
- A61K9/2873—Proteins, e.g. gelatin
Description
Patented Apr. 9, I90L n vantoz f regge f 4 0019/7 MQW N RIS PETERS CO.. PNDTGLITHD.. WAIMINGTON, D. L
(No Model) Wihwooe /l Vfg/f UNITED STATES FREDERICK H. METCALF,
PATENT OFFICE.
OF FRANKLIN, ILLINOIS.
COATED PILL, Sac.
SPECIFICATION formingpart of Letters Patent No. 671,804, dated April 9, 1901. Original application filed December 2, 1899, Serial No. 738,993. Divided and this application filed May 28, 1900. Serial fication.
This invention relates to improvements in coated pills, tablets, lozenges, and the like, and forms part of a divisional application filed December 2, 1899, Serial No. 738,993, allowed May 2, 1900, and patented under No. 650,760.
One object of this improvement is to mix with the coating used in the manufacture of coated pills a sulcient quantity of pepsin to quickly dissolve said coating and make the medicine which is incased more susceptible to the digestive organs when taken into the stomach.
A further object of the improvement is to mix a sufficient quantity of pepsin with the coating for pills when said coating consists primarily of gelatin so as to assist the stornach to quickly and readily digest the coating to permit the exposure of the incased medical compound to the digestive organs.
Many other objects and advantages will be apparent upon further description.
In the drawiri gs forming a part of this specification, Figure l is a sectional view of a pill, showing my improvement applied thereto. Fig. 2 is a similar view showing a modified form of my invention.
Referring to the drawings, the numeral 1 represents a pill as a whole, composed of any suitable medical compound 2 and provided with a coating 3. Mixed with the coating is a sufficient quantity of pepsin or other digestive agent 4.
In the manufacture of pills, tablets, or lozenges for certain reasons it is necessary to provide a coating. In some cases this coating is composed of a mixture which is not readily susceptible to the digestive organs of the stomach; and it is the purpose and objectY of this invention to introduce in its composition a sucient quantity of pepsin so asto enable the stomach to readily 'and quickly reduce the coating and expose the incased medical compound. The coatings for pills, as
(No model.)
before stated, are largely made up of a gelatinous substance, and it is well known this substance is exceedingly difficult to digest, and it not infrequently occurs that a gelatincoated pill absolutely refuses to be subjected to the digestive organs and juices of the stomach, and as a result the pill is taken without any curative result.
While I am aware that the coating of pills is largely gelatin, I am also aware of other substances being used equally as hard to digest and propose to mix pepsin with my coating solution used for pills.
The pepsin is applied to the pill, tablet, or lozenge preferably when the coating is ina liquid state. However, a separate compartment may be made, as disclosed in Fig. 2. In this modification the pepsin is contained between two layers of coating, the outer one of which is thinner than the inner, so much so as to not be a barrier to the juices.
In many cases I may apply enough pepsin to not only reduce the coating around the pill, but to coact with the compound incased within the coating and assist in its digestion.
Having thus described my invention, what I claim isl l. As a new article of manufacture, a pill, tablet or lozenge provided with a gelatinous coating, said coating having pepsin distributed throughout its composition to assist the digestion of said'coating and the rapid liberation of the compound forming the pill, whereby the juices of the stomach, may have immediate action on said compound, substantially as described.
2. As a new article of manufacture, a pill, tablet or lozenge, provided with a gelatinous coating having pepsin uniformly distributed throughout its composition to assist the digestion of said coating and the rapid liberation of the compound forming the pill, whereby the juices of the stomach may have immediate action on said compound, substantially as described.
In testimony whereof I have hereunto set my hand in the presence of two subscribing witnesses.
FREDERICK H. METOALF. Witnesses:
CHARLES A. BARNES, LENA C. ENGEL.
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US18307A US671804A (en) | 1899-12-02 | 1900-05-28 | Coated pill, &c. |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US73899399A US650760A (en) | 1899-12-02 | 1899-12-02 | Gelatin capsule. |
US18307A US671804A (en) | 1899-12-02 | 1900-05-28 | Coated pill, &c. |
Publications (1)
Publication Number | Publication Date |
---|---|
US671804A true US671804A (en) | 1901-04-09 |
Family
ID=2740357
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
US18307A Expired - Lifetime US671804A (en) | 1899-12-02 | 1900-05-28 | Coated pill, &c. |
Country Status (1)
Country | Link |
---|---|
US (1) | US671804A (en) |
Cited By (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3181998A (en) * | 1960-08-12 | 1965-05-04 | Joseph L Kanig | Tablet disintegration |
US3493652A (en) * | 1962-09-14 | 1970-02-03 | Charles W Hartman | Controlled release medicament |
US3943238A (en) * | 1972-11-01 | 1976-03-09 | Meija Seika Co., Ltd. | Method for the preparation of medicinal capsules |
US4261969A (en) * | 1979-05-03 | 1981-04-14 | World Health Organization | Controlled drug release composition |
US4820524A (en) * | 1987-02-20 | 1989-04-11 | Mcneilab, Inc. | Gelatin coated caplets and process for making same |
US4966771A (en) * | 1987-02-20 | 1990-10-30 | Mcneilab, Inc. | Gelatin coated caplets and process for making same |
US5314696A (en) * | 1991-06-27 | 1994-05-24 | Paulos Manley A | Methods for making and administering a blinded oral dosage form and blinded oral dosage form therefor |
US5750145A (en) * | 1995-07-28 | 1998-05-12 | Bristol-Myers Squibb Company | Stable gelatin coated aspirin tablets |
US20030059614A1 (en) * | 1989-09-20 | 2003-03-27 | Hani Sadek | Enrobed core medicament |
-
1900
- 1900-05-28 US US18307A patent/US671804A/en not_active Expired - Lifetime
Cited By (12)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3181998A (en) * | 1960-08-12 | 1965-05-04 | Joseph L Kanig | Tablet disintegration |
US3493652A (en) * | 1962-09-14 | 1970-02-03 | Charles W Hartman | Controlled release medicament |
US3943238A (en) * | 1972-11-01 | 1976-03-09 | Meija Seika Co., Ltd. | Method for the preparation of medicinal capsules |
US4261969A (en) * | 1979-05-03 | 1981-04-14 | World Health Organization | Controlled drug release composition |
US4820524A (en) * | 1987-02-20 | 1989-04-11 | Mcneilab, Inc. | Gelatin coated caplets and process for making same |
US4966771A (en) * | 1987-02-20 | 1990-10-30 | Mcneilab, Inc. | Gelatin coated caplets and process for making same |
US5314537A (en) * | 1987-02-20 | 1994-05-24 | Mcneilab, Inc. | Gelatin coated caplets and process for making same |
US20030059614A1 (en) * | 1989-09-20 | 2003-03-27 | Hani Sadek | Enrobed core medicament |
US5314696A (en) * | 1991-06-27 | 1994-05-24 | Paulos Manley A | Methods for making and administering a blinded oral dosage form and blinded oral dosage form therefor |
US5558878A (en) * | 1991-06-27 | 1996-09-24 | Captab, L.L.C. | Method for blinding a tableted medication |
US5576019A (en) * | 1991-06-27 | 1996-11-19 | Captab 11C | Method for blinding a medication |
US5750145A (en) * | 1995-07-28 | 1998-05-12 | Bristol-Myers Squibb Company | Stable gelatin coated aspirin tablets |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
US671804A (en) | Coated pill, &c. | |
Allen et al. | Corrosive injuries of the stomach | |
DK0632720T3 (en) | Hydroxyethyl cellulose based depot dosage forms | |
US5576019A (en) | Method for blinding a medication | |
DE59407288D1 (en) | BUDESONIDE PELLETS WITH CONTROLLED RELEASE PROFILE AND METHOD FOR THEIR PRODUCTION | |
US650760A (en) | Gelatin capsule. | |
Butte et al. | Optimisation and in vivo evaluation of pectin based drug delivery system containing curcumin for colon | |
Park et al. | Prediction and management of recurrent right colon diverticulitis | |
US2687367A (en) | Medicinal tablet containing identification fragments | |
US1815902A (en) | Device for administering medicaments | |
US2011587A (en) | Coating for medical compound | |
US1863001A (en) | Container for vending machine goods | |
Fenn et al. | Misoprostol—a logical therapeutic approach to gastroduodenal mucosal injury induced by non‐steroidal anti‐inflammatory drugs? | |
Sheikh et al. | Endoscopic evidence of mucosal injury in patients taking ticlopidine compared with patients taking aspirin/nonsteroidal antiinflammatory drugs and controls | |
JPH04193823A (en) | Pill readily crushable with teeth and easily administrable without water | |
US2071511A (en) | Enteric coating | |
US1021674A (en) | Medicinal tablet. | |
US1746984A (en) | Vehicle for acetyl-salicylic acid tablets | |
Kitamura et al. | Tongue necrosis caused by systemic vascular diseases: A systematic review of the literature | |
US149679A (en) | Improvement in medical compounds | |
Shandil et al. | An autopsy based study of corrosive acid poisoning and its medico-legal aspects– | |
US1907203A (en) | Coating for tablets, capsules, and pills | |
US54056A (en) | Improved compound for the cure of dyspepsia | |
US209654A (en) | Improvement in soluble coatings for pills | |
KR100204534B1 (en) | Gold-coated oral refreshment pills and process for preparing thereof |