US6736799B1 - Delivery device for biological composites and method of preparation thereof - Google Patents
Delivery device for biological composites and method of preparation thereof Download PDFInfo
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- US6736799B1 US6736799B1 US09/939,505 US93950501A US6736799B1 US 6736799 B1 US6736799 B1 US 6736799B1 US 93950501 A US93950501 A US 93950501A US 6736799 B1 US6736799 B1 US 6736799B1
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- porosity
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
- A61B17/56—Surgical instruments or methods for treatment of bones or joints; Devices specially adapted therefor
- A61B17/58—Surgical instruments or methods for treatment of bones or joints; Devices specially adapted therefor for osteosynthesis, e.g. bone plates, screws, setting implements or the like
- A61B17/88—Osteosynthesis instruments; Methods or means for implanting or extracting internal or external fixation devices
- A61B17/8802—Equipment for handling bone cement or other fluid fillers
- A61B17/8805—Equipment for handling bone cement or other fluid fillers for introducing fluid filler into bone or extracting it
- A61B17/8825—Equipment for handling bone cement or other fluid fillers for introducing fluid filler into bone or extracting it characterised by syringe details
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
- A61B17/56—Surgical instruments or methods for treatment of bones or joints; Devices specially adapted therefor
- A61B17/58—Surgical instruments or methods for treatment of bones or joints; Devices specially adapted therefor for osteosynthesis, e.g. bone plates, screws, setting implements or the like
- A61B17/88—Osteosynthesis instruments; Methods or means for implanting or extracting internal or external fixation devices
- A61B17/8802—Equipment for handling bone cement or other fluid fillers
- A61B17/8805—Equipment for handling bone cement or other fluid fillers for introducing fluid filler into bone or extracting it
- A61B17/8816—Equipment for handling bone cement or other fluid fillers for introducing fluid filler into bone or extracting it characterised by the conduit, e.g. tube, along which fluid flows into the body or by conduit connections
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/40—Composite materials, i.e. containing one material dispersed in a matrix of the same or different material
- A61L27/44—Composite materials, i.e. containing one material dispersed in a matrix of the same or different material having a macromolecular matrix
- A61L27/46—Composite materials, i.e. containing one material dispersed in a matrix of the same or different material having a macromolecular matrix with phosphorus-containing inorganic fillers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
- A61L27/54—Biologically active materials, e.g. therapeutic substances
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
- A61L27/56—Porous materials, e.g. foams or sponges
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M25/00—Catheters; Hollow probes
- A61M25/0097—Catheters; Hollow probes characterised by the hub
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/178—Syringes
- A61M5/31—Details
- A61M5/32—Needles; Details of needles pertaining to their connection with syringe or hub; Accessories for bringing the needle into, or holding the needle on, the body; Devices for protection of needles
- A61M5/34—Constructions for connecting the needle, e.g. to syringe nozzle or needle hub
Definitions
- the present invention generally relates to apparatuses for the delivery of biological composites that facilitate imbibation and infiltration of porous substrates with biological materials to form biological composites, together with systems and kits comprising the same.
- This application also relates to methods for the preparation and delivery of biologically active composites that may comprise both a substrate material and biological materials.
- the biological composites preferably comprise an inorganic substrate, such as for example, a calcium phosphate inorganic material like beta-tricalcium phosphate (“ ⁇ -TCP”), and a biological component, such as for example, bone marrow aspirate (“BMA”).
- bone grafting can be used to encourage the affected bone to regenerate and heal.
- the graft functions in a manner similar to cancellous bone, supporting new tissue growth by providing the bone and blood cells with a matrix through which to interweave as they reconnect the bone fragments.
- three processes that mimic natural events in cancellous bone should take place: osteoinduction, osteogenesis, and osteoconduction.
- Osteoinduction is the biologically mediated recruitment and differentiation of cell types essential for bone.
- Osteogenesis is the process of bone formation through cellular osteoblastic activity, which, in turn, is dependent upon the presence of osteoprogenitor stem cells.
- osteoconduction is the apposition of growing bone to the three-dimensional surface of a suitable scaffold provided by the graft.
- Orthopedists are currently using a variety of materials that enhance, to various degrees, these three processes.
- the basic types of bone substitutes which are sometimes used alone and sometimes in combination, comprise the autograft, cadaveric allograft, xenograft, and several types of graft materials.
- materials used for bone grafts will provide for osteogenesis, osteoinduction, and osteoconduction, resulting in vigorous new bone growth that will repair the defect.
- One effective bone graft material in current use is the autogenous cancellous bone graft.
- survival of intrinsic osteogenic stem cells in the autograft is not optimal, and the harvesting process (generally from the iliac crest) results in considerable morbidity to the patient.
- alternative bone-grafting strategies have been investigated. The development of composite grafts that combine synthetic cancellous bone void fillers with autogenous bone-forming cells could simplify and improve grafting procedures.
- U.S. Pat. No. 4,551,135 discloses a syringe for the extrusion of a semi-plastic mass, having a barrel which may be pre-loaded with a semi-plastic mass or one component of a multi-component plasticizable mixture, and which may be fitted at its exit end with removable means for making an inter-connection with a filling syringe to a add a second liquid, component to the dispensing syringe.
- Gorman teaches that the barrel is flared toward its lower end.
- U.S. Pat. No. 4,065,360 (“Kreb”) discloses a syringe device for drawing blood or other fluids directly into a sealed sterile environment.
- the syringe includes a hollow housing, a movable piston, at least one culture cavity in the walls of the housing and sealing means about the periphery of the movable piston such that after fluid is withdrawn into contact with the culture cavities, the piston may be moved back upwardly to seal the culturing media with respect to the outside environment and to the chamber within the syringe to allow for sterile culturing of the fluid.
- Kreb also teaches a hollow nipple means attached to one end of the syringe adapted to receive a needle.
- U.S. Pat. No. 4,801,263 (“Clark”) discloses a device for placing osseous implant substances into interdental alveolar bone defects.
- the device includes a syringe barrel member having an inlet and an outlet, a syringe plunger member having a piston rod, grasping members attached to an external surface of the syringe barrel and a threaded nozzle coupler attached to the exterior of the barrel member for allowing an extended nozzle member, preferably curved, to be attached to the syringe barrel.
- U.S. Pat. No. 5,772,665 (“Glad”) discloses a device for mixing a pharmaceutical composition which includes a hollow body having an outlet sealed by a removable closure, a plunger slidable therein in sealing contact with the inner wall of the hollow body, actuating means for displacing the plunger, a chamber for housing the pharmaceutical composition, a filling conduit connected to the chamber, and a check valve associated with the conduit and the chamber which prevents flow from the chamber but permits flow into the chamber through the conduit. Glad discloses that water can be added to the chamber in one of two ways: withdrawing the plunger upward and allowing water to enter through the lower end; or by placing the lid on the lower end, removing the plunger and pouring/injecting water into the upper opening. When the filling is complete, either the lid is applied to the lower end or the plunger is re-inserted into the hollow body, respectively.
- U.S. Pat. Nos. 5,824,084 and 6,049,026 disclose a method of preparing a composite bone graft and apparatus for preparing an implantable graft, respectively, which includes a porous, biocompatible, implantable substrate, a container for retaining the substrate and for permitting flow of a bone marrow aspirate suspension (bone marrow aspirate that may include an isotonic solution and an anti-coagulant) completely through the substrate into an effluent container for receiving effluent of the bone marrow aspirate suspension from the container.
- Muschler also teaches a graft having an enriched population of connective tissue progenitor cells, the graft being the resultant product of the disclosed method and apparatus.
- the present invention provides an apparatus capable of housing a substrate material.
- the material is infiltrated with a biological substance to provide a biological composite.
- the present invention provides an apparatus for preparing a biological composite comprising a material chamber, having a proximal end and a distal end, containing a calcium phosphate material having macro-, meso- and micro-porosity, the proximal end being sealingly closed by a movable plunger; and the distal end of the chamber being closed by a dismountable end cap, the end cap being provided with a point for attachment of an aspiration needle.
- the apparatus further comprises a closed end cap that is interchangeable with the dismountable end cap for sealing the material chamber between the plunger and the closed end cap.
- a method for preparing a biological composite comprising the steps of: providing an apparatus comprising a material chamber comprising an inorganic, biologically compatible material having macro-, meso- and micro-porosity and having a proximal end and a distal end, the proximal end being sealingly closed by a movable plunger; the distal end of the chamber being closed by a dismountable end cap, the end cap being provided with a point for attachment of an aspiration needle; attaching the aspiration needle to the dismountable end cap; placing the aspiration needle into a situs of bone marrow; operating the plunger to draw a partial vacuum in the material chamber and to cause aspiration of bone marrow into the material chamber in an amount sufficient to substantially wet the biologically compatible morselate material; and maintaining the aspirate in contact with the biologically compatible composite under conditions effective to cause at least partial coalescence of the marrow-morselate mixture.
- the inorganic, biologically compatible material having macro-, mes
- kits for the preparation and delivery of biologically active composites comprising an instrument for the injection and the withdrawal of one or more biological fluids and a porous, biocompatible material wherein the porous, biocompatible material comprises interconnected micro-, meso- and macro-porosity.
- FIGS. 1A and 1B are side elevation and exploded views, respectively, of an exemplary delivery device of the present invention.
- FIG. 2 is the device of FIGS. 1A and 1B, showing the morselate material housed within.
- FIG. 3 is a 100 ⁇ magnification scanning electron micrograph (“SEM”) of an exemplary inorganic substrate material that depicts the macro-, meso-and micro-porosity contained therein.
- FIGS. 4A through 4C illustrate an exemplary method of the present invention in which the apparatus of FIGS. 1A and 1B is used in the following manner: (A) a biological material, such as BMA, is drawn into the device thereby infiltrating the porous substrate material, (B) the plunger is depressed against the congealed mass of material and BMA, and the end piece of the device is removed to provide a biological composite and (C) the biological composite is delivered to an osseous defect site.
- a biological material such as BMA
- the present invention relates to an apparatus for the delivery of a biological composite that houses a substrate material, allows for the substrate material to be rendered biologically active to form a biological composite, and facilitates delivery of the biological composite to an osseous defect site.
- the substrate material is a highly porous ⁇ -TCP with a pore volume of at least 70% and interconnected porosity of pore sizes that may range from less than about 1 ⁇ m to about 1000 ⁇ m or greater.
- FIGS. 1A, 1 B, and 2 provide one example of a presently preferred embodiment of the present invention.
- apparatus 10 comprises a material chamber 20 having a proximal end 21 and a distal end 22 defining an interior chamber therein for housing a porous substrate as shown as 120 in FIG. 2 .
- material chamber 20 may be tubular or cylindrical shaped.
- material chamber 20 may have external calibration markings 30 (see FIG. 1A) to measure the amount of material housed, drawn into, or aspirated within or into material chamber 20 .
- Apparatus 10 may further include a piston or gasket 40 , as shown in FIGS. 1B and 2, which may reside within the material chamber 20 and is moveable therein via engaging plunger 50 attached thereto.
- Plunger 50 is removable from the housing to allow for material insertion within the material chamber 20 , or the injection of any desired material, such as biologic material, into chamber 20 .
- the distal end 22 of apparatus 10 is provided with a removable dismountable end cap 60 with a proximal end 61 having threads, guides, slots, or other structures for engaging corresponding threads, guides, slots or other structures on the distal end 22 of the material chamber 20 .
- Dismountable end cap 60 further includes a distal end 62 with a point for attachment 63 of an aspiration needle 110 .
- the point for attachment 63 is a male Luer lock connector 90 that threadingly engages the distal end 62 of the dismountable end cap 60 and allows for attachment of a female Luer lock 100 situated on the end of a needle 110 for the aspiration of fluids.
- the male Luer lock connector 90 is integrated with the distal end 63 of the dismountable end cap 60 (not shown).
- An adhesive such as but not limited to a polyurethane adhesive, may also be used between dismountable end cap 60 and Luer lock connector 90 to form an integrated piece.
- An exemplary polyurethane adhesive is Product #1187-M provided by Dymax Corporation of Torrington, Conn.
- material chamber 20 further includes a substrate material 120 contained therein.
- Substrate material 120 may be comprised of a variety of synthetic biocompatible bone materials and ceramic materials, including, but not limited to, those comprising calcium phosphate.
- Material 120 may be in a variety of forms such as an integral body of porous material, granules, or morsels.
- Preferred biocompatible materials are those obtained generally in accordance with the disclosure of pending application, U.S. Ser. No. 08/784,439 filed Jan. 16, 1997, assigned to the assignee of the present invention and incorporated herein by reference in its entirety.
- Such ⁇ -tricalcium materials exhibit a high degree of porosity over a wide range of effective pore sizes.
- substrate material 120 is an integral body of porous material
- the body preferably exhibits within its microstructure, a combination of macro-porosity, meso-porosity, and micro-porosity.
- Macro-porosity as used herein, relates to materials characterized by pore diameters about 100 ⁇ m or greater, and more preferably up to about 1000 ⁇ m.
- Meso-porosity as used herein, relates to materials characterized by pore diameters that range from about 10 to about 100 ⁇ m.
- Micro-porosity as used herein, relates to materials characterized by pore diameters below about 10 ⁇ m, and more preferably about 1 ⁇ m or below.
- 3 provides a SEM of the microstructure of a preferred substrate material that may be used in the present invention. It is preferred that macro-, meso- and micro-porosity simultaneously occur in a random and interconnected nature throughout the porous substrate material used in the present invention. It is not necessary to quantify each type of porosity to a high degree. Rather, persons skilled in the art can easily determine whether a material has each type of porosity through examination, such as through the SEM or other methods known in the art.
- porous substrate material 120 may have pore volumes of at least about 70% or greater, preferably about 85% or greater, and even more preferably about 90% or greater. Such high pore volumes may be achieved while also maintaining the presence of macro-, meso-, and micro-porosity within the microstructure and physical stability of the materials produced. These aspects of the porous substrate material are desirable for use within the apparatuses, kits, systems, and methods of the present invention in that they facilitate wicking of the biological material and infiltration of the viable components of the biological fluid.
- porous scaffold material 120 may comprise a tri-calcium phosphate such as ⁇ -TCP.
- porous scaffold material comprising ⁇ -TCP may be resorbable.
- the composition, physical structure and solubility of the implant may strongly influence the resorption of calcium-based bone implants.
- the preferred porous bodies have significant resorption due to their low density, high porosity, nano-size particle composition, and chemistry. As calcium-based implants are resorbed, they are often replaced by new bone. Porous tri-calcium phosphate bone implants resorb more quickly than porous hydroxyapatite, with their resorption rate being concurrent with a rapid rate of in-growth and remodeling of new bone if the structure of the implant is appropriate.
- the infiltrant in the present invention can be a number of substances that render the porous material bioactive including, but not limited to, biological materials such as bone marrow, whole blood, plasma or other blood components or growth factors, but preferably contains one or more components of BMA.
- BMA is a complex tissue comprised of cellular components (that contribute to bone growth) including red and white blood cells, their precursors and a connective tissue network termed the stroma.
- Bone marrow stromal cells or mesenchymal stem cells have the potential to differentiate into a variety of identifiable cell types including osteoblasts, fibroblasts, endothelial cells, reticulocytes, adipocytes, myoblasts and marrow stroma.
- bone marrow aspirate is a good source of osteogenic cells for immediate transplantation.
- stem cells can also be cultured and expanded many times to increase their original number.
- Stromal cells regulate the differentiation of hemopoietic cells through cell-surface protein interactions and secretion of growth factors.
- Bone marrow may be used to stimulate bone healing in many applications providing a promptly renewable, reliable source of osteogenic cells.
- BMA may also provide osteogenic components, namely the progenitors of osteoblasts.
- the present invention device is provided with means for preparing and delivering a biological composite that may be osteoconductive, osteogenic and osteoinductive.
- the tri-calcium phosphate materials of the type disclosed herein have been shown to function as osteoconductive bone graft scaffolds.
- the resultant material may become osteogenic and osteoinductive.
- the osteogenic and osteoinductive potential is further enhanced due to the interconnected porosity of the material which facilitates infusion of bone matrix proteins and growth factors. Osteogenic cells can also migrate into the open architecture of the scaffold and mingle with the seeded bone-forming cells, thereby enhancing the osteogenic properties of the ⁇ -TCP.
- the present invention finds utility in a wide variety of applications and may provides an alternative to autografts, or implantation materials comprised of cadaver bone, bovine bone, or the like.
- the porous scaffold material and biological composite formed therein can be used in medicine, such as, but not limited to, the restoration of bony defects.
- the materials can also be used for the delivery of medicaments that are internal to the defect.
- the pores of the substrate can be partially filled with another material which either comprises or carries a medicament such as a growth hormone, antibiotic, cell signaling material, or the like.
- the larger porous spaces within some of the products of the present invention can be used for the culturing of cells within the human body.
- the larger spaces are amenable to the growth of cells and can be permeated readily by bodily fluids such as certain blood components.
- growing cells can be implanted in an animal through the aegis of implants in accordance with the present invention. These implants can give rise to important biochemical or therapeutic or other uses.
- the apparatus is used to prepare a biological composite using the method and kit depicted in FIGS. 4A, 4 B and 4 C.
- plunger 50 or dismountable end cap 65 is removed from apparatus 10 and the biocompatible material 120 is inserted into material chamber 20 .
- Dismountable end cap 65 is an integral piece that comprises Luer lock connector 95 .
- Luer lock mating means 105 with needle attachment 110 may be connected thereto.
- Plunger 50 is then reinserted into, or dismountable end cap 65 is placed back onto, material chamber 20 .
- Piston 40 is dispaced so that it abuts and lightly packs the material (not shown).
- Biopsy needle 110 is then inserted into an appropriate anatomical site 130 , such as for example the iliac crest.
- Biopsy needle 110 preferably has a solid trochar (not shown).
- the syringe is then connected to needle 110 via the Luer lock mating means 105 and connector 95 . Withdrawal of the plunger creates a vacuum within the housing 20 , which allows for the biological fluid to be drawn into the housing of the device as shown in FIG. 4 A.
- the fluid completely imbibes and infiltrates the biocompatible material 120 , once in contact with the material, by virtue of its highly porous and interconnected porosity.
- the plunger is depressed so that it abuts and compacts both the material and infiltrate so that the two are allowed to coagulate within the housing to form a biological composite 140 having an improved handling consistency and osteogenic potential.
- the resulting composite 140 behaves as a unit mass and can be surgically implanted via displacement of the plunger 50 , upon removal of the dismountable end cap 65 .
- a wrench (not shown) may be used that mates with dismountable end cap 65 to aid in opening and closing the syringe.
- material chamber 20 may be pre-filled with BMA or another biocompatible material and dismountable end cap 60 or plunger 50 may be removed to insert substrate material 120 .
- the composite 140 can be packed into a bony void to create good contact with available bony surfaces.
- the resultant composite is sufficiently self-supporting to be handled manually or with surgical hand tools such as spatulas and knives.
- the composite need not be entirely stiff but can tend to flow under force.
- a shapeable portion of the composite is placed into a void 150 in a bone 160 as shown in FIG. 4 C. Any remaining biological composite 140 can be preserved in a freezer or other suitable means of preserving.
- BMA infiltrants
- venous blood venous blood
- thrombin thrombin
- fluids such as culture-expanded cells or solutions containing medicaments. Such fluids should improve the handling characteristics of the scaffold and impart a beneficial biological function by the nature of the fluid chosen.
- kits that are unique in its ability to prepare and deliver the biologically active composite.
- a preferred kit embodiment is comprised of an apparatus or delivery device capable of holding porous, biocompatible material as described herein and a separate sterile package holding the inorganic material.
- the kit is used to prepare a biologically active composite wherein BMA or other infiltrant is absorbed into the porous material by the aspiration process.
- the composite is formed within the barrel of the syringe once the aspirate coagulates with the porous material.
- the same kit can be used to deliver the resultant composite by removing the end of the syringe and extruding the composite to be placed into an osseous void.
- the material chamber or barrel and threaded dismountable end cap may be comprised of a polycarbonate material, such as that sold by Dow, 2081-15-FC030004;
- the plunger may be comprised of acrylonitrile-butadiene-styrene (such as the Dow Magnum 9010 material);
- the piston or gasket may be comprised of a silicone-64 Shore A durometer base material, such as the blend of STI-5 and TR-70 sold by Dow Corning;
- a lubricant between the inside of the barrel and the plunger piston is preferably silicone oil (such as Dow Coming Silicone 360);
- the adhesive on the threaded coupling between the Luer lock and dismountable end cap may be medical grade silicone or a number of acceptable adhesives including, but not limited to, cyanoacrylate, hot melt adhesives, or cellulosic binders.
- the Luer lock and dismountable end cap may be medical grade silicone or a number of acceptable adhesives including, but not limited to, cyanoacrylate
- a kit of the present invention for the aspiration of borie marrow, whole blood, plasma or other blood components was evaluated using a non-human primate animal model.
- the kit was evaluated for collection of bone marrow and venous blood, with and without a highly porous calcium phosphate scaffold material, in the following manner.
- a 20-gauge needle was affixed to a male Luer-lock adaptor situated on the end of the syringe system.
- An 18-gauge catheter was placed in the right lateral saphenous vein of the animal for repeated blood collection, then the 20 gauge needle was placed in contact with the 18 gauge catheter for collection of venous blood.
- the ability of the syringe system to draw blood was subjectively evaluated with and without the addition of 5 cc of a morselate calcium phosphate material in the material chamber of the syringe. This evaluation was compared a Luer Lock 10 cc disposable syringe, manufactured by the Becton Dickinson Co. of Rutherford, N.J., with the addition of 5 cc of the morselate calcium phosphate material described above.
- the syringe system was evaluated during harvest of bone marrow aspirate from the posterior superior iliac spine region of the right ileum using an 11-gauge Jamshidi needle was placed directly in the site the syringe system was and then attached for aspiration.
- the ability of the syringe system to aspirate bone marrow was subjectively evaluated with and without the addition of 5 cc of a morselate calcium phosphate material in the material chamber of the syringe.
- the syringe system both with and without the addition of 5 cc of a morselate calcium phosphate material in the material chamber, was sufficient for both collection of venous blood and the harvest of bone marrow aspirate. Adding the porous material to the chamber had no effect on the ability of the system to draw blood or aspirate marrow. The vacuum that was generated in each case was sufficient. There were no differences between a first draw of blood with the syringe system in comparison with a second draw from the same syringe.
- VITOSSTM Scaffold Synthetic Cancellous Bone Void Filler morsels (provided by Orthovita of Malvern, Pa.), referred to herein as “Test Articles” were prepared and assigned a unique identification number for the study.
- Table I provides the animal subjects' ID number, test article ID numbers, amount of biological material imbibed into the VITOSSTM porous scaffold material, and the amount in grams of the-residual VITOSSTM and BMA composite.
- Surgical procedures were scheduled in “sessions”, with three surgical procedures typically performed per session. Prior to the start of each surgery session, a vial of the Test Article was removed from the sterile packaging for use during the entire session. Care was taken to maintain sterility of the vial throughout the session.
- each vial of Test Article was weighed prior to, and following, removal of material for placement in each Test System. The total amount of Test Article used in each Test System was determined in this way.
- the syringe containing the Test Article was attached to the needle being used for BMA collection.
- BMA was either: (1) drawn into the syringe through the Test Article such that it completely saturated it; or (2) drawn into a 1 cc syringe and then transferred to the 5 cc syringe containing the VITOSSTM scaffold material such that the BMA completely saturated it. In some instances, the syringe was removed to withdraw air and reattached.
- a four-pin, Type 1 Kirschner external fixator was placed on the anterio-lateral aspect of the experimental tibia.
- a medial skin incision approximately 3 cm in length was made and exposure of the tibia was obtained using sharp and blunt dissection. Once exposed, the periosteum was scored and reflected back. The major axis of the mid-section of the tibia was then measured.
- a cortical segmental defect approximately two times the mid-shaft major axis dimension was created in the mid-tibia using an oscillating saw.
- the defect was then completely filled with the VITOSSTM scaffold material with BMA and the periosteum closed with a non-absorbable suture to contain it.
- the residual amount of remaining biological composite after the defect was filled is shown in Table 1 .
- the soft tissues were closed in layers.
Abstract
Description
TABLE I | |||
Residual | |||
Amount Mixed | VITOSS ™ /BMA | ||
Animal ID | Test Article ID | (g) | (cc) |
11A | ORL-131-T | 0.72 | 0.9 |
11B | ORL-101-T | 0.54 | 0.3 |
11C | ORL-117-T | 0.72 | 1.0 |
11D | ORL-131-T | 0.80 | 0.7 |
11E | ORL-109-T | 0.37 | 0.4 |
12A | ORL-134-T | 0.79 | NA |
12B | ORL-119-T | 1.04 | NA |
12C | ORL-101-T | 1.21 | NA |
12D | ORL-109-T | 0.45 | NA |
12E | ORL-127-T | 1.15* | 3.0* |
13A | ORL-113-T | 0.76 | 0.2 |
13B | ORL-113-T | 0.85 | 0.3 |
13C | ORL-119-T | 0.77 | NA |
13D | ORL-118-T | 0.94 | 0.3 |
13E | ORL-131-T | 0.88 | 0.6 |
14A | ORL-134-T | 0.86 | 0.3 |
14B | ORL-118-T | 1.61* | NA* |
14C | ORL-100-T | 0.93 | NA |
14D | ORL-133-T | 0.79 | NA |
14E | ORL-133-T | 0.97 | NA |
15A | ORL-113-T | 0.79 | NA |
15B | ORL-134-T | 0.83 | 0.4 |
15C | ORL-133-T | 0.75 | 0.1 |
15D | ORL-131-T | 0.84 | 0.5 |
15E | ORL-109-T | 0.74 | NA |
16A | ORL-134-T | 0.73 | NA |
16B | ORL-119-T | 0.81 | NA |
16C | ORL-117-T | 0.75 | NA |
16D | ORL-117-T | 1.05 | NA |
16E | ORL-127-T | 0.90 | NA |
*An additional quantity of VITOSS ™ /BMA was prepared for use if necessary. |
Claims (17)
Priority Applications (5)
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US09/939,505 US6736799B1 (en) | 2000-10-24 | 2001-08-24 | Delivery device for biological composites and method of preparation thereof |
PCT/US2001/049948 WO2002040963A2 (en) | 2000-10-24 | 2001-10-23 | Biologically active composites and methods for their production and use |
AU2002241691A AU2002241691A1 (en) | 2000-10-24 | 2001-10-23 | Biologically active composites and methods for their production and use |
US10/818,419 US7052517B2 (en) | 2000-10-24 | 2004-04-05 | Delivery device for biological composites and method of preparation thereof |
US11/384,576 US8876911B2 (en) | 2000-10-24 | 2006-03-20 | Delivery device for biological composites and method of preparation thereof |
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