US7052864B2 - Bioanalytical measuring method using oxidases and lanthanoid-ligand complexes - Google Patents
Bioanalytical measuring method using oxidases and lanthanoid-ligand complexes Download PDFInfo
- Publication number
- US7052864B2 US7052864B2 US10/093,103 US9310302A US7052864B2 US 7052864 B2 US7052864 B2 US 7052864B2 US 9310302 A US9310302 A US 9310302A US 7052864 B2 US7052864 B2 US 7052864B2
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- US
- United States
- Prior art keywords
- oxidase
- enzyme
- lanthanoid
- hydrogen peroxide
- ligand complex
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related, expires
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Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/557—Immunoassay; Biospecific binding assay; Materials therefor using kinetic measurement, i.e. time rate of progress of an antigen-antibody interaction
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C237/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
- C07C237/24—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a ring other than a six-membered aromatic ring of the carbon skeleton
- C07C237/26—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a ring other than a six-membered aromatic ring of the carbon skeleton of a ring being part of a condensed ring system formed by at least four rings, e.g. tetracycline
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/26—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving oxidoreductase
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/58—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances
- G01N33/582—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances with fluorescent label
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2458/00—Labels used in chemical analysis of biological material
- G01N2458/40—Rare earth chelates
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- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Immunology (AREA)
- Organic Chemistry (AREA)
- Molecular Biology (AREA)
- Urology & Nephrology (AREA)
- Hematology (AREA)
- Biomedical Technology (AREA)
- Biotechnology (AREA)
- Microbiology (AREA)
- General Health & Medical Sciences (AREA)
- Analytical Chemistry (AREA)
- Physics & Mathematics (AREA)
- Biochemistry (AREA)
- Zoology (AREA)
- General Physics & Mathematics (AREA)
- Pathology (AREA)
- Medicinal Chemistry (AREA)
- Wood Science & Technology (AREA)
- Cell Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Food Science & Technology (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- General Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Investigating Or Analysing Materials By The Use Of Chemical Reactions (AREA)
Abstract
Description
C6H12O6+O2→C6H10O6+H2O2
(glucose+oxygen→gluconic acid lactone+hydrogen peroxide).
-
- creatinine+creatinine aminohydrolase→creatine
- creatine+creatinase→sarcosine+urea
sarcosine+sarcosine oxidase+O2+glycine+formaldehyde+hydrogen peroxide
Ln(III)x-Ligy
in which
-
- Ln(III) is a trivalent ion from the group of lanthanoids,
- x and y are independently integers from 1 to 20 and the ratio of x:y is 10:1 to 1:3 and
- Lig is an organic ligand that binds to the lanthanoid ion,
wherein hydrogen peroxide causes a change in the absorption or fluorescence properties of the lanthanoid-ligand complex.
-
- X can be OH, NHR4, NR4 2,
- R1 to R4 can be H, an alkyl, a cycloalkyl, an alkanoyl, a cycloalkanoyl, an aroyl, CF3,
- a substituted or non-substituted alkyl residue or an alkanoyl residue, OH, NH2, alkylamino or dialkylamino,
where each of the residues R1 to R4 can be linked via a substituted or unsubstituted carboxyclic or heterocyclic ring to one of the other residues R1 to R4 and R1 to R4 has 1 to 30 and preferably 1 to 12 C atoms.
-
- creatine (+creatinase)===>sarcosine+urea
- sarcosine (+sarcosine oxidase)===>glycine+formaldehyde+H2O2
-
- cholesterol (+cholesterol oxidase)====>cholest-4-ene-3-one+H2O2
-
- pyruvate+phosphate (+pyruvate oxidase)===>acetyl phosphate+H2O2
-
- triglycerides (+lipase)===>glycerol+fatty acids
- glycerol+ATP (+glycerol kinase)===>glycerol-1-phosphate+ATP
- glycerol-1-phosphate (+oxidase)===>dihydroxyacetone phosphate+H2O2
-
- L-alanine+2-ketoglutarate (+ALT)===>pyruvate+glutamate
- pyruvate+phosphate (+pyruvate oxidase)===>acetylphosphate+H2O2
-
- tyrosine (+tyrosine decarboxylase)===>tyramine
- tyramine (+tyramine oxidase)===>p-hydroxyphenylacetaldehyde+H2O2
-
- choline (+choline oxidase)===>betaine+H2O2
-
- pyruvate+NADH (+lactate dehydrogenase)===>lactate
- lactate (+lactate oxidase)===>pyruvate+H2O2
-
- Peptide (+HIV proteinase)===>amino acid (e.g. Ala; Leu)+residual peptide
- amino acid (+AA oxidase)===>
- ===>oxidized amino acid (e.g. pyruvate, α ketoisocaproate)+H2O2
-
- urea (+urease)=>ammonia+bicarbonate
- ammonia+2-oxoglutarate+NADPH (+glutamate-dehydrogenase)=>
- =>glutamate+NADP
- glutamate (+glutamate oxidase)=degradation product+H2O2
-
- 100 μl of a 10% solution of urea in Tris buffer pH 8.0;
- 2 mg glutamate dehydrogenase (E.C.1.4.1.3) dissolved in 10 μl Tris buffer:
- 1 mg NADPH (Na salt; Sigma N-1630) dissolved in 10 μl buffer;
Claims (26)
Lnx-Ligy
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE10111392.7 | 2001-03-09 | ||
DE10111392A DE10111392A1 (en) | 2001-03-09 | 2001-03-09 | Bioanalytical measurement method using oxidases |
Publications (2)
Publication Number | Publication Date |
---|---|
US20020137027A1 US20020137027A1 (en) | 2002-09-26 |
US7052864B2 true US7052864B2 (en) | 2006-05-30 |
Family
ID=7676880
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
US10/093,103 Expired - Fee Related US7052864B2 (en) | 2001-03-09 | 2002-03-08 | Bioanalytical measuring method using oxidases and lanthanoid-ligand complexes |
Country Status (3)
Country | Link |
---|---|
US (1) | US7052864B2 (en) |
EP (1) | EP1239049B1 (en) |
DE (2) | DE10111392A1 (en) |
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US20090029870A1 (en) * | 2007-04-02 | 2009-01-29 | Ward Michael D | Particle Analyzing Systems and Methods Using Acoustic Radiation Pressure |
US20090107241A1 (en) * | 2007-10-24 | 2009-04-30 | Los Alamos National Security, Llc | Method for non-contact particle manipulation and control of particle spacing along an axis |
US20090139332A1 (en) * | 2007-10-24 | 2009-06-04 | Goddard Gregory Russ | Method for non-contact particle manipulation and control of particle spacing along an axis |
US20090158823A1 (en) * | 2007-12-19 | 2009-06-25 | Gregory Kaduchak | Particle analysis in an acoustic cytometer |
US20100000325A1 (en) * | 2004-07-29 | 2010-01-07 | Gregory Kaduchak | Ultrasonic analyte concentration and application in flow cytometry |
US7648468B2 (en) | 2002-04-19 | 2010-01-19 | Pelikon Technologies, Inc. | Method and apparatus for penetrating tissue |
US7666149B2 (en) | 1997-12-04 | 2010-02-23 | Peliken Technologies, Inc. | Cassette of lancet cartridges for sampling blood |
US7674232B2 (en) | 2002-04-19 | 2010-03-09 | Pelikan Technologies, Inc. | Method and apparatus for penetrating tissue |
US7682318B2 (en) | 2001-06-12 | 2010-03-23 | Pelikan Technologies, Inc. | Blood sampling apparatus and method |
US7699791B2 (en) | 2001-06-12 | 2010-04-20 | Pelikan Technologies, Inc. | Method and apparatus for improving success rate of blood yield from a fingerstick |
US7713214B2 (en) | 2002-04-19 | 2010-05-11 | Pelikan Technologies, Inc. | Method and apparatus for a multi-use body fluid sampling device with optical analyte sensing |
US7717863B2 (en) | 2002-04-19 | 2010-05-18 | Pelikan Technologies, Inc. | Method and apparatus for penetrating tissue |
US7731729B2 (en) | 2002-04-19 | 2010-06-08 | Pelikan Technologies, Inc. | Method and apparatus for penetrating tissue |
US20100167386A1 (en) * | 2003-09-10 | 2010-07-01 | Abbott Point Of Care Inc. | Immunosensor system for blood with reduced interference |
US7822454B1 (en) | 2005-01-03 | 2010-10-26 | Pelikan Technologies, Inc. | Fluid sampling device with improved analyte detecting member configuration |
US7833171B2 (en) | 2002-04-19 | 2010-11-16 | Pelikan Technologies, Inc. | Method and apparatus for penetrating tissue |
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US7850621B2 (en) | 2003-06-06 | 2010-12-14 | Pelikan Technologies, Inc. | Method and apparatus for body fluid sampling and analyte sensing |
US7862520B2 (en) | 2002-04-19 | 2011-01-04 | Pelikan Technologies, Inc. | Body fluid sampling module with a continuous compression tissue interface surface |
US7874994B2 (en) | 2002-04-19 | 2011-01-25 | Pelikan Technologies, Inc. | Method and apparatus for penetrating tissue |
US20110032522A1 (en) * | 2006-11-03 | 2011-02-10 | Los Alamos National Security, Llc | System and Method for Measuring Particles in a Sample Stream of a Flow Cytometer or the Like |
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-
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- 2002-03-08 US US10/093,103 patent/US7052864B2/en not_active Expired - Fee Related
- 2002-03-08 DE DE50208739T patent/DE50208739D1/en not_active Expired - Lifetime
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EP1239049A3 (en) | 2003-08-27 |
US20020137027A1 (en) | 2002-09-26 |
DE50208739D1 (en) | 2007-01-04 |
EP1239049B1 (en) | 2006-11-22 |
DE10111392A1 (en) | 2002-09-12 |
EP1239049A2 (en) | 2002-09-11 |
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