US7081188B1 - Electric-current biosensor - Google Patents
Electric-current biosensor Download PDFInfo
- Publication number
- US7081188B1 US7081188B1 US11/033,636 US3363605A US7081188B1 US 7081188 B1 US7081188 B1 US 7081188B1 US 3363605 A US3363605 A US 3363605A US 7081188 B1 US7081188 B1 US 7081188B1
- Authority
- US
- United States
- Prior art keywords
- support
- electric
- pair
- current biosensor
- activity area
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
- 230000000694 effects Effects 0.000 claims abstract description 42
- 238000012360 testing method Methods 0.000 claims abstract description 29
- 230000013011 mating Effects 0.000 claims abstract description 7
- 108090000790 Enzymes Proteins 0.000 claims description 8
- 102000004190 Enzymes Human genes 0.000 claims description 8
- 229940088598 enzyme Drugs 0.000 claims description 8
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 8
- 239000000853 adhesive Substances 0.000 claims description 7
- 230000001070 adhesive effect Effects 0.000 claims description 7
- 239000000203 mixture Substances 0.000 claims description 7
- 239000012790 adhesive layer Substances 0.000 claims description 6
- 239000004094 surface-active agent Substances 0.000 claims description 6
- 229920001213 Polysorbate 20 Polymers 0.000 claims description 4
- 239000007853 buffer solution Substances 0.000 claims description 4
- 235000010486 polyoxyethylene sorbitan monolaurate Nutrition 0.000 claims description 4
- 239000000256 polyoxyethylene sorbitan monolaurate Substances 0.000 claims description 4
- 239000003223 protective agent Substances 0.000 claims description 4
- 102000009027 Albumins Human genes 0.000 claims description 2
- 108010088751 Albumins Proteins 0.000 claims description 2
- 229920002307 Dextran Polymers 0.000 claims description 2
- 239000004375 Dextrin Substances 0.000 claims description 2
- 229920001353 Dextrin Polymers 0.000 claims description 2
- 108010015776 Glucose oxidase Proteins 0.000 claims description 2
- 239000004366 Glucose oxidase Substances 0.000 claims description 2
- 229920001214 Polysorbate 60 Polymers 0.000 claims description 2
- ZLMJMSJWJFRBEC-UHFFFAOYSA-N Potassium Chemical group [K] ZLMJMSJWJFRBEC-UHFFFAOYSA-N 0.000 claims description 2
- DBMJMQXJHONAFJ-UHFFFAOYSA-M Sodium laurylsulphate Chemical compound [Na+].CCCCCCCCCCCCOS([O-])(=O)=O DBMJMQXJHONAFJ-UHFFFAOYSA-M 0.000 claims description 2
- 150000001413 amino acids Chemical class 0.000 claims description 2
- 239000003599 detergent Substances 0.000 claims description 2
- 235000019425 dextrin Nutrition 0.000 claims description 2
- 239000012153 distilled water Substances 0.000 claims description 2
- 229940116332 glucose oxidase Drugs 0.000 claims description 2
- 235000019420 glucose oxidase Nutrition 0.000 claims description 2
- 239000008055 phosphate buffer solution Substances 0.000 claims description 2
- 235000010482 polyoxyethylene sorbitan monooleate Nutrition 0.000 claims description 2
- 229920000053 polysorbate 80 Polymers 0.000 claims description 2
- 229910052700 potassium Inorganic materials 0.000 claims description 2
- 239000011591 potassium Substances 0.000 claims description 2
- 235000019333 sodium laurylsulphate Nutrition 0.000 claims description 2
- 239000002390 adhesive tape Substances 0.000 claims 1
- 239000008280 blood Substances 0.000 description 11
- 210000004369 blood Anatomy 0.000 description 11
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 description 8
- 239000008103 glucose Substances 0.000 description 8
- 150000002500 ions Chemical class 0.000 description 4
- 230000005484 gravity Effects 0.000 description 3
- 230000001052 transient effect Effects 0.000 description 3
- 238000005259 measurement Methods 0.000 description 2
- 238000012986 modification Methods 0.000 description 2
- 230000004048 modification Effects 0.000 description 2
- 238000006467 substitution reaction Methods 0.000 description 2
- 238000006243 chemical reaction Methods 0.000 description 1
- 238000013461 design Methods 0.000 description 1
- 238000011835 investigation Methods 0.000 description 1
- 239000002609 medium Substances 0.000 description 1
- 238000000034 method Methods 0.000 description 1
- 229920000136 polysorbate Polymers 0.000 description 1
- 238000012545 processing Methods 0.000 description 1
- 238000006479 redox reaction Methods 0.000 description 1
- 238000011160 research Methods 0.000 description 1
Images
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/001—Enzyme electrodes
- C12Q1/005—Enzyme electrodes involving specific analytes or enzymes
- C12Q1/006—Enzyme electrodes involving specific analytes or enzymes for glucose
Definitions
- the present invention relates to an electric-current biosensor, and particularly to an electric-current biosensor that can be operated more easily to avoid the inconvenience of having to aim samples towards test holes, so that the samples can be guided more easily and effectively into the activity area for obtaining an accurate testing value.
- the simplest current method of determining blood glucose levels uses an electric-current biosensor, later applying the sample (such as blood) onto an electric-current biosensor.
- the electric-current biosensor allows an oxidation-reduction reaction to take place in the sample, thereby producing electric ions.
- the ions accumulate into an electric current on the electric-current biosensor.
- An electric-current biosensor is inserted into a measure meter for comparing and analyzing the current, thereby determining the blood glucose concentration.
- FIG. 3 illustrates an electric-current biosensor of the prior art.
- the electric-current biosensor has an activity area 44 and conductive electrodes 46 , which form the structure of a small contact area, thereby creating a small transient current. Without a sufficient current the measure meter cannot perform value comparing or analysis, and the measuring accuracy is affected.
- FIG. 4 shows an improved electric-current biosensor of another prior art.
- the improved electric-current biosensor is designed to overcome the disadvantages caused by the small reaction area as seen in FIG. 3 .
- the improved electric-current biosensor provides a larger electrode contacting area for obtaining an accurate reading.
- the biosensor has a support 48 , which consists of a second support 52 covering a part of a first support 50 .
- the first support 50 has a positive electrode 54 , a negative electrode 56 and an activity area 58 .
- the activity area 58 covers a portion of the positive electrode 54 and the negative electrode 56 .
- the second support 52 has a circle testing port 60 and an electrode film 62 .
- the testing port 60 corresponds to the activity area 58 .
- the electrode film 62 is formed on the periphery around the testing port 60 .
- the first support 50 is covered by the second support 52 and the blood sample is applied onto the activity area 58 .
- the electrodes of the first support 50 and the second support 52 overlap each other to create a larger transient current, thereby improving the accuracy of the measure meter.
- the measure meter cannot achieve a sufficient measuring current quickly enough to perform value comparing and analyzing.
- the electric-current biosensor of the related art still has some inconveniences and disadvantages that can be improved upon.
- the inventor after investigation and research, thus provides the present invention of logical design for improving the above-mentioned imperfections.
- An objective of the present invention is to provide an electric-current biosensor that has a pair of testing ports formed on two sides thereof which is more convenient for users.
- Another objective of the present invention is to provide an electric-current biosensor that is tilted slightly, therefore ensuring the sample will flow into the testing port to avoid wasting samples.
- Another objective of the present invention is to provide an electric-current biosensor that increases the transient electric current and improves the accuracy of blood glucose testing.
- an electric-current biosensor which comprises a support, a pair of positive and negative electrodes, an activity area, and an electrode film.
- the support has a first support and a second support covered adhesively on the first support, wherein the second support is concaved with a pair of testing ports on two sides thereof.
- the pair of positive and negative electrodes is disposed on the first support.
- the pair of positive and negative electrodes are co-planar.
- the positive electrode has a positive electrode film and a positive conductive film.
- the negative electrode has a negative electrode film and a negative conductive film.
- the activity area is formed on the first support and is covered with the pair of positive and negative electrode films.
- the electrode film is formed on the second support and corresponds to the activity area.
- the electrode film is covered with the pair of positive and negative electrode films.
- the pair of testing ports mate with the activity area and are exposed outside a part of the activity area when the first support is covered by the second support.
- FIG. 1 is a top view of an unfolded electrical-current biosensor according to the present invention
- FIG. 2 is a top view of a folded electrical-current biosensor according to the present invention.
- FIG. 3 is a top view of an unfolded electrical-current biosensor of a related art.
- FIG. 4 is a side view of an unfolded electrical-current biosensor of another related art.
- the present invention provides an electric-current biosensor comprised of a support 10 , a pair of positive and negative electrodes 18 , 20 , an activity area 30 , and an electrode film 32 .
- the support 12 has a folding line 10 formed thereon to divide into a first support 14 and a second support 16 .
- the first support 14 is longer than the second support 16 .
- the folding line 10 is between the first support 14 and the second support 16 for folding and covering the second support 16 on the first support 14 .
- the first support 14 is formed with a positive electrode 18 and a negative electrode 20 which are coplanar.
- the positive electrode 18 and the negative electrode 20 are separated and do not overlap.
- the positive electrode 18 has a positive electrode film 22 and a positive conductive film 24 .
- a unit of the positive electrode film 22 is larger than that of the positive conductive film 24 .
- the negative electrode 20 has a negative electrode film 26 and a negative conductive film 28 .
- a unit of the negative electrode film 26 is larger than that of the negative conductive film 28 .
- the activity area 30 is on the positive electrode film 22 and the negative electrode film 26 .
- the composition of the activity area 30 accords to the item being measuring, the blood glucose, and consists of enzyme, enzyme protective agent, a conductive medium, surfactant, buffer solution, and water. Each composition is instanced as followed:
- Enzyme such as glucose oxidase, etc.
- Enzyme protective agent such as albumin, dextrin, dextran, amino acid, etc.
- a conductive medium such as potassium, etc.
- a surfactant such as TritonX-100, TritonX-405, TritonX-114, sodium lauryl sulfate, polyoxyethylenesorbitan monolaurate (Tween 20), Tween 40, Tween 60, Tween 80, another water surfactant, or detergent;
- a buffer solution i.e. slats, such as phosphate buffer solution, etc.
- Water such as distilled water.
- the electrode film 32 is formed on the second support 16 and corresponds to the activity area 30 .
- the electrode film 32 is covered with the pair of positive and negative electrode films 22 and 26 .
- the electrode film 32 is applied to a mating activity area 34 by spreading.
- the mating activity area 34 has the same composition as the activity area 30 .
- the second support 16 is concaved with a pair of semicircular testing ports 36 and 38 on two sides thereof, which correspond to the activity area 30 .
- An adhesive layer 40 is disposed on the second support 16 to bond with the first and second supports 14 and 16 together.
- the adhesive layer 40 is disposed on two sides of the activity area 30 , and does not cover the mating activity area 34 , the testing ports 36 and 38 or a portion of the free end of the second support 16 .
- the portion of the free end of the second support 16 is defined as an operating area 42 .
- the adhesive layer 40 is a twin adhesive with a height of approximately 0.3 mm, which has an insulating base, so that the positive and negative electrodes 18 and 20 on the first support 14 do not cause a short circuit of the biosensor when the electrode film 32 on the second support 16 covers the first support 14 .
- the support 12 when using the electric-current biosensor, the support 12 is folded along the folding line 10 , and the second support 16 covers the first support 14 .
- the pair of testing ports 36 and 38 of the second support 16 mate with the activity area 30 and are exposed outside a part of the activity area 30 .
- the electrode film 32 overlaps above the positive electrode film 22 and the negative electrode film 26 .
- the first and second supports 14 and 16 are joined together by the adhesive layer 40 .
- the operator When measuring the blood glucose, the operator drops an appropriate amount of sample into one of the testing ports 36 or 38 .
- the sample is then forced by gravity to flow into the activity area 30 , it then diffuses and, because of the pressure, the sample oxidates within the activity area 30 quickly and produces electric ions.
- the electric ions move between the positive electrode 18 and the negative electrode 20 .
- the biosensor further cooperates with a measure meter to compare and analyze the current for determining the blood glucose concentration.
- the present invention improves upon the disadvantages of the prior art.
- the circle testing port of the related art causes the sample to flow outside of the testing area, wasting samples and not providing accurate measurements. Especially when the sample is not applied properly in the testing port of the prior art, the sample will be pulled by gravity and will flow outside the support along the surface thereof because the biosensor is titled.
- the present invention forces the sample to flow into the activity area fully and raises the electrical current, thereby improving the accuracy of the measure meter.
Abstract
Description
Claims (19)
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US11/033,636 US7081188B1 (en) | 2005-01-13 | 2005-01-13 | Electric-current biosensor |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US11/033,636 US7081188B1 (en) | 2005-01-13 | 2005-01-13 | Electric-current biosensor |
Publications (2)
Publication Number | Publication Date |
---|---|
US20060151323A1 US20060151323A1 (en) | 2006-07-13 |
US7081188B1 true US7081188B1 (en) | 2006-07-25 |
Family
ID=36652172
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
US11/033,636 Expired - Fee Related US7081188B1 (en) | 2005-01-13 | 2005-01-13 | Electric-current biosensor |
Country Status (1)
Country | Link |
---|---|
US (1) | US7081188B1 (en) |
Cited By (56)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20090095622A1 (en) * | 2007-10-11 | 2009-04-16 | Ching-Hsin Cho | Biosensor and method to produce biosensor |
US20090211344A1 (en) * | 2006-12-22 | 2009-08-27 | Yi Wang | Analyte sensors and methods of use |
US7648468B2 (en) | 2002-04-19 | 2010-01-19 | Pelikon Technologies, Inc. | Method and apparatus for penetrating tissue |
US7666149B2 (en) | 1997-12-04 | 2010-02-23 | Peliken Technologies, Inc. | Cassette of lancet cartridges for sampling blood |
US7674232B2 (en) | 2002-04-19 | 2010-03-09 | Pelikan Technologies, Inc. | Method and apparatus for penetrating tissue |
US7682318B2 (en) | 2001-06-12 | 2010-03-23 | Pelikan Technologies, Inc. | Blood sampling apparatus and method |
US7699791B2 (en) | 2001-06-12 | 2010-04-20 | Pelikan Technologies, Inc. | Method and apparatus for improving success rate of blood yield from a fingerstick |
US7713214B2 (en) | 2002-04-19 | 2010-05-11 | Pelikan Technologies, Inc. | Method and apparatus for a multi-use body fluid sampling device with optical analyte sensing |
US7717863B2 (en) | 2002-04-19 | 2010-05-18 | Pelikan Technologies, Inc. | Method and apparatus for penetrating tissue |
US7731729B2 (en) | 2002-04-19 | 2010-06-08 | Pelikan Technologies, Inc. | Method and apparatus for penetrating tissue |
US7822454B1 (en) | 2005-01-03 | 2010-10-26 | Pelikan Technologies, Inc. | Fluid sampling device with improved analyte detecting member configuration |
US7833171B2 (en) | 2002-04-19 | 2010-11-16 | Pelikan Technologies, Inc. | Method and apparatus for penetrating tissue |
US7841992B2 (en) | 2001-06-12 | 2010-11-30 | Pelikan Technologies, Inc. | Tissue penetration device |
US7850621B2 (en) | 2003-06-06 | 2010-12-14 | Pelikan Technologies, Inc. | Method and apparatus for body fluid sampling and analyte sensing |
US7862520B2 (en) | 2002-04-19 | 2011-01-04 | Pelikan Technologies, Inc. | Body fluid sampling module with a continuous compression tissue interface surface |
US7874994B2 (en) | 2002-04-19 | 2011-01-25 | Pelikan Technologies, Inc. | Method and apparatus for penetrating tissue |
US20110037194A1 (en) * | 2009-08-14 | 2011-02-17 | Michael David James | Die assembly and method of using same |
US7892183B2 (en) | 2002-04-19 | 2011-02-22 | Pelikan Technologies, Inc. | Method and apparatus for body fluid sampling and analyte sensing |
US7901362B2 (en) | 2002-04-19 | 2011-03-08 | Pelikan Technologies, Inc. | Method and apparatus for penetrating tissue |
US7909778B2 (en) | 2002-04-19 | 2011-03-22 | Pelikan Technologies, Inc. | Method and apparatus for penetrating tissue |
US7909775B2 (en) | 2001-06-12 | 2011-03-22 | Pelikan Technologies, Inc. | Method and apparatus for lancet launching device integrated onto a blood-sampling cartridge |
US7909777B2 (en) | 2002-04-19 | 2011-03-22 | Pelikan Technologies, Inc | Method and apparatus for penetrating tissue |
US7914465B2 (en) | 2002-04-19 | 2011-03-29 | Pelikan Technologies, Inc. | Method and apparatus for penetrating tissue |
US7959582B2 (en) | 2002-04-19 | 2011-06-14 | Pelikan Technologies, Inc. | Method and apparatus for penetrating tissue |
US7976476B2 (en) | 2002-04-19 | 2011-07-12 | Pelikan Technologies, Inc. | Device and method for variable speed lancet |
US7988645B2 (en) | 2001-06-12 | 2011-08-02 | Pelikan Technologies, Inc. | Self optimizing lancing device with adaptation means to temporal variations in cutaneous properties |
US8007446B2 (en) | 2002-04-19 | 2011-08-30 | Pelikan Technologies, Inc. | Method and apparatus for penetrating tissue |
US8079960B2 (en) | 2002-04-19 | 2011-12-20 | Pelikan Technologies, Inc. | Methods and apparatus for lancet actuation |
US8197421B2 (en) | 2002-04-19 | 2012-06-12 | Pelikan Technologies, Inc. | Method and apparatus for penetrating tissue |
US8221334B2 (en) | 2002-04-19 | 2012-07-17 | Sanofi-Aventis Deutschland Gmbh | Method and apparatus for penetrating tissue |
US8267870B2 (en) | 2002-04-19 | 2012-09-18 | Sanofi-Aventis Deutschland Gmbh | Method and apparatus for body fluid sampling with hybrid actuation |
US8282576B2 (en) | 2003-09-29 | 2012-10-09 | Sanofi-Aventis Deutschland Gmbh | Method and apparatus for an improved sample capture device |
US8333710B2 (en) | 2002-04-19 | 2012-12-18 | Sanofi-Aventis Deutschland Gmbh | Tissue penetration device |
US8435190B2 (en) | 2002-04-19 | 2013-05-07 | Sanofi-Aventis Deutschland Gmbh | Method and apparatus for penetrating tissue |
US8439872B2 (en) | 1998-03-30 | 2013-05-14 | Sanofi-Aventis Deutschland Gmbh | Apparatus and method for penetration with shaft having a sensor for sensing penetration depth |
US8652831B2 (en) | 2004-12-30 | 2014-02-18 | Sanofi-Aventis Deutschland Gmbh | Method and apparatus for analyte measurement test time |
US8668656B2 (en) | 2003-12-31 | 2014-03-11 | Sanofi-Aventis Deutschland Gmbh | Method and apparatus for improving fluidic flow and sample capture |
US8702624B2 (en) | 2006-09-29 | 2014-04-22 | Sanofi-Aventis Deutschland Gmbh | Analyte measurement device with a single shot actuator |
US8721671B2 (en) | 2001-06-12 | 2014-05-13 | Sanofi-Aventis Deutschland Gmbh | Electric lancet actuator |
US8828203B2 (en) | 2004-05-20 | 2014-09-09 | Sanofi-Aventis Deutschland Gmbh | Printable hydrogels for biosensors |
US8956518B2 (en) | 2011-04-20 | 2015-02-17 | Lifescan, Inc. | Electrochemical sensors with carrier field |
US8965476B2 (en) | 2010-04-16 | 2015-02-24 | Sanofi-Aventis Deutschland Gmbh | Tissue penetration device |
US9034639B2 (en) | 2002-12-30 | 2015-05-19 | Sanofi-Aventis Deutschland Gmbh | Method and apparatus using optical techniques to measure analyte levels |
US9072842B2 (en) | 2002-04-19 | 2015-07-07 | Sanofi-Aventis Deutschland Gmbh | Method and apparatus for penetrating tissue |
US9144401B2 (en) | 2003-06-11 | 2015-09-29 | Sanofi-Aventis Deutschland Gmbh | Low pain penetrating member |
US9226699B2 (en) | 2002-04-19 | 2016-01-05 | Sanofi-Aventis Deutschland Gmbh | Body fluid sampling module with a continuous compression tissue interface surface |
US9248267B2 (en) | 2002-04-19 | 2016-02-02 | Sanofi-Aventis Deustchland Gmbh | Tissue penetration device |
US9314194B2 (en) | 2002-04-19 | 2016-04-19 | Sanofi-Aventis Deutschland Gmbh | Tissue penetration device |
US9351680B2 (en) | 2003-10-14 | 2016-05-31 | Sanofi-Aventis Deutschland Gmbh | Method and apparatus for a variable user interface |
US9375169B2 (en) | 2009-01-30 | 2016-06-28 | Sanofi-Aventis Deutschland Gmbh | Cam drive for managing disposable penetrating member actions with a single motor and motor and control system |
US9386944B2 (en) | 2008-04-11 | 2016-07-12 | Sanofi-Aventis Deutschland Gmbh | Method and apparatus for analyte detecting device |
US9427532B2 (en) | 2001-06-12 | 2016-08-30 | Sanofi-Aventis Deutschland Gmbh | Tissue penetration device |
US9560993B2 (en) | 2001-11-21 | 2017-02-07 | Sanofi-Aventis Deutschland Gmbh | Blood testing apparatus having a rotatable cartridge with multiple lancing elements and testing means |
US9795747B2 (en) | 2010-06-02 | 2017-10-24 | Sanofi-Aventis Deutschland Gmbh | Methods and apparatus for lancet actuation |
US9820684B2 (en) | 2004-06-03 | 2017-11-21 | Sanofi-Aventis Deutschland Gmbh | Method and apparatus for a fluid sampling device |
US9839386B2 (en) | 2002-04-19 | 2017-12-12 | Sanofi-Aventis Deustschland Gmbh | Body fluid sampling device with capacitive sensor |
Families Citing this family (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CA2694085A1 (en) * | 2007-07-23 | 2009-01-29 | Agamatrix, Inc. | Electrochemical test strip |
TWM328565U (en) * | 2007-07-31 | 2008-03-11 | Biomedix Taiwan Co Ltd | Biochemical sensor |
CN102914571B (en) * | 2012-09-13 | 2014-07-09 | 华南师范大学 | Glucose detection device and glucose detection method |
Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6299757B1 (en) * | 1998-10-08 | 2001-10-09 | Therasense, Inc. | Small volume in vitro analyte sensor with diffusible or non-leachable redox mediator |
US6521110B1 (en) * | 1995-11-16 | 2003-02-18 | Lifescan, Inc. | Electrochemical cell |
US6923894B2 (en) * | 1999-11-11 | 2005-08-02 | Apex Biotechnology Corporation | Biosensor with multiple sampling ways |
-
2005
- 2005-01-13 US US11/033,636 patent/US7081188B1/en not_active Expired - Fee Related
Patent Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6521110B1 (en) * | 1995-11-16 | 2003-02-18 | Lifescan, Inc. | Electrochemical cell |
US6299757B1 (en) * | 1998-10-08 | 2001-10-09 | Therasense, Inc. | Small volume in vitro analyte sensor with diffusible or non-leachable redox mediator |
US6923894B2 (en) * | 1999-11-11 | 2005-08-02 | Apex Biotechnology Corporation | Biosensor with multiple sampling ways |
Cited By (113)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US7666149B2 (en) | 1997-12-04 | 2010-02-23 | Peliken Technologies, Inc. | Cassette of lancet cartridges for sampling blood |
US8439872B2 (en) | 1998-03-30 | 2013-05-14 | Sanofi-Aventis Deutschland Gmbh | Apparatus and method for penetration with shaft having a sensor for sensing penetration depth |
US9427532B2 (en) | 2001-06-12 | 2016-08-30 | Sanofi-Aventis Deutschland Gmbh | Tissue penetration device |
US7988645B2 (en) | 2001-06-12 | 2011-08-02 | Pelikan Technologies, Inc. | Self optimizing lancing device with adaptation means to temporal variations in cutaneous properties |
US9802007B2 (en) | 2001-06-12 | 2017-10-31 | Sanofi-Aventis Deutschland Gmbh | Methods and apparatus for lancet actuation |
US7682318B2 (en) | 2001-06-12 | 2010-03-23 | Pelikan Technologies, Inc. | Blood sampling apparatus and method |
US7699791B2 (en) | 2001-06-12 | 2010-04-20 | Pelikan Technologies, Inc. | Method and apparatus for improving success rate of blood yield from a fingerstick |
US7981055B2 (en) | 2001-06-12 | 2011-07-19 | Pelikan Technologies, Inc. | Tissue penetration device |
US8845550B2 (en) | 2001-06-12 | 2014-09-30 | Sanofi-Aventis Deutschland Gmbh | Tissue penetration device |
US8721671B2 (en) | 2001-06-12 | 2014-05-13 | Sanofi-Aventis Deutschland Gmbh | Electric lancet actuator |
US8679033B2 (en) | 2001-06-12 | 2014-03-25 | Sanofi-Aventis Deutschland Gmbh | Tissue penetration device |
US8641643B2 (en) | 2001-06-12 | 2014-02-04 | Sanofi-Aventis Deutschland Gmbh | Sampling module device and method |
US8622930B2 (en) | 2001-06-12 | 2014-01-07 | Sanofi-Aventis Deutschland Gmbh | Tissue penetration device |
US7841992B2 (en) | 2001-06-12 | 2010-11-30 | Pelikan Technologies, Inc. | Tissue penetration device |
US7850622B2 (en) | 2001-06-12 | 2010-12-14 | Pelikan Technologies, Inc. | Tissue penetration device |
US9694144B2 (en) | 2001-06-12 | 2017-07-04 | Sanofi-Aventis Deutschland Gmbh | Sampling module device and method |
US7909775B2 (en) | 2001-06-12 | 2011-03-22 | Pelikan Technologies, Inc. | Method and apparatus for lancet launching device integrated onto a blood-sampling cartridge |
US8360991B2 (en) | 2001-06-12 | 2013-01-29 | Sanofi-Aventis Deutschland Gmbh | Tissue penetration device |
US8343075B2 (en) | 2001-06-12 | 2013-01-01 | Sanofi-Aventis Deutschland Gmbh | Tissue penetration device |
US8282577B2 (en) | 2001-06-12 | 2012-10-09 | Sanofi-Aventis Deutschland Gmbh | Method and apparatus for lancet launching device integrated onto a blood-sampling cartridge |
US8216154B2 (en) | 2001-06-12 | 2012-07-10 | Sanofi-Aventis Deutschland Gmbh | Tissue penetration device |
US8211037B2 (en) | 2001-06-12 | 2012-07-03 | Pelikan Technologies, Inc. | Tissue penetration device |
US8206319B2 (en) | 2001-06-12 | 2012-06-26 | Sanofi-Aventis Deutschland Gmbh | Tissue penetration device |
US8382683B2 (en) | 2001-06-12 | 2013-02-26 | Sanofi-Aventis Deutschland Gmbh | Tissue penetration device |
US8206317B2 (en) | 2001-06-12 | 2012-06-26 | Sanofi-Aventis Deutschland Gmbh | Tissue penetration device |
US8162853B2 (en) | 2001-06-12 | 2012-04-24 | Pelikan Technologies, Inc. | Tissue penetration device |
US8123700B2 (en) | 2001-06-12 | 2012-02-28 | Pelikan Technologies, Inc. | Method and apparatus for lancet launching device integrated onto a blood-sampling cartridge |
US8016774B2 (en) | 2001-06-12 | 2011-09-13 | Pelikan Technologies, Inc. | Tissue penetration device |
US9560993B2 (en) | 2001-11-21 | 2017-02-07 | Sanofi-Aventis Deutschland Gmbh | Blood testing apparatus having a rotatable cartridge with multiple lancing elements and testing means |
US7959582B2 (en) | 2002-04-19 | 2011-06-14 | Pelikan Technologies, Inc. | Method and apparatus for penetrating tissue |
US9226699B2 (en) | 2002-04-19 | 2016-01-05 | Sanofi-Aventis Deutschland Gmbh | Body fluid sampling module with a continuous compression tissue interface surface |
US7988644B2 (en) | 2002-04-19 | 2011-08-02 | Pelikan Technologies, Inc. | Method and apparatus for a multi-use body fluid sampling device with sterility barrier release |
US7976476B2 (en) | 2002-04-19 | 2011-07-12 | Pelikan Technologies, Inc. | Device and method for variable speed lancet |
US8007446B2 (en) | 2002-04-19 | 2011-08-30 | Pelikan Technologies, Inc. | Method and apparatus for penetrating tissue |
US9839386B2 (en) | 2002-04-19 | 2017-12-12 | Sanofi-Aventis Deustschland Gmbh | Body fluid sampling device with capacitive sensor |
US9795334B2 (en) | 2002-04-19 | 2017-10-24 | Sanofi-Aventis Deutschland Gmbh | Method and apparatus for penetrating tissue |
US8062231B2 (en) | 2002-04-19 | 2011-11-22 | Pelikan Technologies, Inc. | Method and apparatus for penetrating tissue |
US8079960B2 (en) | 2002-04-19 | 2011-12-20 | Pelikan Technologies, Inc. | Methods and apparatus for lancet actuation |
US7938787B2 (en) | 2002-04-19 | 2011-05-10 | Pelikan Technologies, Inc. | Method and apparatus for penetrating tissue |
US7914465B2 (en) | 2002-04-19 | 2011-03-29 | Pelikan Technologies, Inc. | Method and apparatus for penetrating tissue |
US8197421B2 (en) | 2002-04-19 | 2012-06-12 | Pelikan Technologies, Inc. | Method and apparatus for penetrating tissue |
US8197423B2 (en) | 2002-04-19 | 2012-06-12 | Pelikan Technologies, Inc. | Method and apparatus for penetrating tissue |
US8202231B2 (en) | 2002-04-19 | 2012-06-19 | Sanofi-Aventis Deutschland Gmbh | Method and apparatus for penetrating tissue |
US7909777B2 (en) | 2002-04-19 | 2011-03-22 | Pelikan Technologies, Inc | Method and apparatus for penetrating tissue |
US7909778B2 (en) | 2002-04-19 | 2011-03-22 | Pelikan Technologies, Inc. | Method and apparatus for penetrating tissue |
US7909774B2 (en) | 2002-04-19 | 2011-03-22 | Pelikan Technologies, Inc. | Method and apparatus for penetrating tissue |
US7901362B2 (en) | 2002-04-19 | 2011-03-08 | Pelikan Technologies, Inc. | Method and apparatus for penetrating tissue |
US8221334B2 (en) | 2002-04-19 | 2012-07-17 | Sanofi-Aventis Deutschland Gmbh | Method and apparatus for penetrating tissue |
US9724021B2 (en) | 2002-04-19 | 2017-08-08 | Sanofi-Aventis Deutschland Gmbh | Method and apparatus for penetrating tissue |
US8267870B2 (en) | 2002-04-19 | 2012-09-18 | Sanofi-Aventis Deutschland Gmbh | Method and apparatus for body fluid sampling with hybrid actuation |
US7648468B2 (en) | 2002-04-19 | 2010-01-19 | Pelikon Technologies, Inc. | Method and apparatus for penetrating tissue |
US7892183B2 (en) | 2002-04-19 | 2011-02-22 | Pelikan Technologies, Inc. | Method and apparatus for body fluid sampling and analyte sensing |
US7674232B2 (en) | 2002-04-19 | 2010-03-09 | Pelikan Technologies, Inc. | Method and apparatus for penetrating tissue |
US8333710B2 (en) | 2002-04-19 | 2012-12-18 | Sanofi-Aventis Deutschland Gmbh | Tissue penetration device |
US8337420B2 (en) | 2002-04-19 | 2012-12-25 | Sanofi-Aventis Deutschland Gmbh | Tissue penetration device |
US8337419B2 (en) | 2002-04-19 | 2012-12-25 | Sanofi-Aventis Deutschland Gmbh | Tissue penetration device |
US9498160B2 (en) | 2002-04-19 | 2016-11-22 | Sanofi-Aventis Deutschland Gmbh | Method for penetrating tissue |
US7874994B2 (en) | 2002-04-19 | 2011-01-25 | Pelikan Technologies, Inc. | Method and apparatus for penetrating tissue |
US8382682B2 (en) | 2002-04-19 | 2013-02-26 | Sanofi-Aventis Deutschland Gmbh | Method and apparatus for penetrating tissue |
US7862520B2 (en) | 2002-04-19 | 2011-01-04 | Pelikan Technologies, Inc. | Body fluid sampling module with a continuous compression tissue interface surface |
US8388551B2 (en) | 2002-04-19 | 2013-03-05 | Sanofi-Aventis Deutschland Gmbh | Method and apparatus for multi-use body fluid sampling device with sterility barrier release |
US8403864B2 (en) | 2002-04-19 | 2013-03-26 | Sanofi-Aventis Deutschland Gmbh | Method and apparatus for penetrating tissue |
US8414503B2 (en) | 2002-04-19 | 2013-04-09 | Sanofi-Aventis Deutschland Gmbh | Methods and apparatus for lancet actuation |
US8430828B2 (en) | 2002-04-19 | 2013-04-30 | Sanofi-Aventis Deutschland Gmbh | Method and apparatus for a multi-use body fluid sampling device with sterility barrier release |
US8435190B2 (en) | 2002-04-19 | 2013-05-07 | Sanofi-Aventis Deutschland Gmbh | Method and apparatus for penetrating tissue |
US7713214B2 (en) | 2002-04-19 | 2010-05-11 | Pelikan Technologies, Inc. | Method and apparatus for a multi-use body fluid sampling device with optical analyte sensing |
US9314194B2 (en) | 2002-04-19 | 2016-04-19 | Sanofi-Aventis Deutschland Gmbh | Tissue penetration device |
US8579831B2 (en) | 2002-04-19 | 2013-11-12 | Sanofi-Aventis Deutschland Gmbh | Method and apparatus for penetrating tissue |
US7833171B2 (en) | 2002-04-19 | 2010-11-16 | Pelikan Technologies, Inc. | Method and apparatus for penetrating tissue |
US9248267B2 (en) | 2002-04-19 | 2016-02-02 | Sanofi-Aventis Deustchland Gmbh | Tissue penetration device |
US7981056B2 (en) | 2002-04-19 | 2011-07-19 | Pelikan Technologies, Inc. | Methods and apparatus for lancet actuation |
US9186468B2 (en) | 2002-04-19 | 2015-11-17 | Sanofi-Aventis Deutschland Gmbh | Method and apparatus for penetrating tissue |
US9089294B2 (en) | 2002-04-19 | 2015-07-28 | Sanofi-Aventis Deutschland Gmbh | Analyte measurement device with a single shot actuator |
US8690796B2 (en) | 2002-04-19 | 2014-04-08 | Sanofi-Aventis Deutschland Gmbh | Method and apparatus for penetrating tissue |
US9089678B2 (en) | 2002-04-19 | 2015-07-28 | Sanofi-Aventis Deutschland Gmbh | Method and apparatus for penetrating tissue |
US7731729B2 (en) | 2002-04-19 | 2010-06-08 | Pelikan Technologies, Inc. | Method and apparatus for penetrating tissue |
US9072842B2 (en) | 2002-04-19 | 2015-07-07 | Sanofi-Aventis Deutschland Gmbh | Method and apparatus for penetrating tissue |
US8905945B2 (en) | 2002-04-19 | 2014-12-09 | Dominique M. Freeman | Method and apparatus for penetrating tissue |
US7717863B2 (en) | 2002-04-19 | 2010-05-18 | Pelikan Technologies, Inc. | Method and apparatus for penetrating tissue |
US9034639B2 (en) | 2002-12-30 | 2015-05-19 | Sanofi-Aventis Deutschland Gmbh | Method and apparatus using optical techniques to measure analyte levels |
US8251921B2 (en) | 2003-06-06 | 2012-08-28 | Sanofi-Aventis Deutschland Gmbh | Method and apparatus for body fluid sampling and analyte sensing |
US7850621B2 (en) | 2003-06-06 | 2010-12-14 | Pelikan Technologies, Inc. | Method and apparatus for body fluid sampling and analyte sensing |
US10034628B2 (en) | 2003-06-11 | 2018-07-31 | Sanofi-Aventis Deutschland Gmbh | Low pain penetrating member |
US9144401B2 (en) | 2003-06-11 | 2015-09-29 | Sanofi-Aventis Deutschland Gmbh | Low pain penetrating member |
US8945910B2 (en) | 2003-09-29 | 2015-02-03 | Sanofi-Aventis Deutschland Gmbh | Method and apparatus for an improved sample capture device |
US8282576B2 (en) | 2003-09-29 | 2012-10-09 | Sanofi-Aventis Deutschland Gmbh | Method and apparatus for an improved sample capture device |
US9351680B2 (en) | 2003-10-14 | 2016-05-31 | Sanofi-Aventis Deutschland Gmbh | Method and apparatus for a variable user interface |
US9561000B2 (en) | 2003-12-31 | 2017-02-07 | Sanofi-Aventis Deutschland Gmbh | Method and apparatus for improving fluidic flow and sample capture |
US8296918B2 (en) | 2003-12-31 | 2012-10-30 | Sanofi-Aventis Deutschland Gmbh | Method of manufacturing a fluid sampling device with improved analyte detecting member configuration |
US8668656B2 (en) | 2003-12-31 | 2014-03-11 | Sanofi-Aventis Deutschland Gmbh | Method and apparatus for improving fluidic flow and sample capture |
US8828203B2 (en) | 2004-05-20 | 2014-09-09 | Sanofi-Aventis Deutschland Gmbh | Printable hydrogels for biosensors |
US9261476B2 (en) | 2004-05-20 | 2016-02-16 | Sanofi Sa | Printable hydrogel for biosensors |
US9820684B2 (en) | 2004-06-03 | 2017-11-21 | Sanofi-Aventis Deutschland Gmbh | Method and apparatus for a fluid sampling device |
US8652831B2 (en) | 2004-12-30 | 2014-02-18 | Sanofi-Aventis Deutschland Gmbh | Method and apparatus for analyte measurement test time |
US7822454B1 (en) | 2005-01-03 | 2010-10-26 | Pelikan Technologies, Inc. | Fluid sampling device with improved analyte detecting member configuration |
US8702624B2 (en) | 2006-09-29 | 2014-04-22 | Sanofi-Aventis Deutschland Gmbh | Analyte measurement device with a single shot actuator |
US9097660B2 (en) | 2006-12-22 | 2015-08-04 | Abbott Diabetes Care Inc. | Analyte sensors and methods of use |
US20090211344A1 (en) * | 2006-12-22 | 2009-08-27 | Yi Wang | Analyte sensors and methods of use |
US9465005B2 (en) | 2006-12-22 | 2016-10-11 | Abbott Diabetes Care Inc. | Analyte sensors and methods of use |
US8033162B2 (en) | 2006-12-22 | 2011-10-11 | Abbott Diabetes Care Inc. | Analyte sensors and methods of use |
US8753470B2 (en) | 2006-12-22 | 2014-06-17 | Abbott Diabetes Care Inc. | Analyte sensors and methods of use |
US8511147B2 (en) | 2006-12-22 | 2013-08-20 | Abbott Diabetes Care Inc. | Analyte sensors and methods of use |
US7802467B2 (en) | 2006-12-22 | 2010-09-28 | Abbott Diabetes Care Inc. | Analyte sensors and methods of use |
US20090095622A1 (en) * | 2007-10-11 | 2009-04-16 | Ching-Hsin Cho | Biosensor and method to produce biosensor |
US9386944B2 (en) | 2008-04-11 | 2016-07-12 | Sanofi-Aventis Deutschland Gmbh | Method and apparatus for analyte detecting device |
US9375169B2 (en) | 2009-01-30 | 2016-06-28 | Sanofi-Aventis Deutschland Gmbh | Cam drive for managing disposable penetrating member actions with a single motor and motor and control system |
US20110037194A1 (en) * | 2009-08-14 | 2011-02-17 | Michael David James | Die assembly and method of using same |
US10704166B2 (en) | 2009-08-14 | 2020-07-07 | The Procter & Gamble Company | Die assembly and method of using same |
US11739444B2 (en) | 2009-08-14 | 2023-08-29 | The Procter & Gamble Company | Die assembly and methods of using same |
US8965476B2 (en) | 2010-04-16 | 2015-02-24 | Sanofi-Aventis Deutschland Gmbh | Tissue penetration device |
US9795747B2 (en) | 2010-06-02 | 2017-10-24 | Sanofi-Aventis Deutschland Gmbh | Methods and apparatus for lancet actuation |
US8956518B2 (en) | 2011-04-20 | 2015-02-17 | Lifescan, Inc. | Electrochemical sensors with carrier field |
US9869653B2 (en) | 2011-04-20 | 2018-01-16 | Lifescan, Inc. | Electrochemical sensors with carrier field |
Also Published As
Publication number | Publication date |
---|---|
US20060151323A1 (en) | 2006-07-13 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
US7081188B1 (en) | Electric-current biosensor | |
TWI491878B (en) | Dual chamber, multi-analyte test strip with opposing electrodes | |
US8758582B2 (en) | Electrochemical test strip | |
JP7003103B2 (en) | Interference compensation type 2-electrode test strip | |
TWI481867B (en) | Test meter for use with a dual chamber, multi-analyte test strip with opposing electrodes | |
US6562210B1 (en) | Cell for electrochemical anaylsis of a sample | |
US6863800B2 (en) | Electrochemical biosensor strip for analysis of liquid samples | |
JP4505837B2 (en) | Analyzing device with temperature detector | |
ES2639542T3 (en) | Methods to analyze a sample in the presence of interferents | |
WO2005066638A1 (en) | Analytical instrument having improved arrangement of reagent section and analytical method | |
JP2003028826A5 (en) | ||
AU2010224341A1 (en) | Multi-analyte test strip with inline working electrodes and shared opposing counter/reference electrode | |
US8840776B2 (en) | Method and sensor strip for analysis of a sample | |
KR20140137410A (en) | Test strip with stacked unidirectional contact | |
JP5139538B2 (en) | Potential difference sensor chip, potential difference measuring method, and measurement kit | |
EP1571442B1 (en) | Analyser system | |
JP5391338B2 (en) | Biological information measuring apparatus and biological information measuring method using the same | |
CN101430336A (en) | Method for hemachrome or hematocrit detection by electro-chemistry method, and detection test piece thereof | |
US7413640B2 (en) | Foldable, electric-current conductivity biosensor | |
TWM346412U (en) | Biochemical sensor | |
AU2016200514B2 (en) | Electrochemical test strip | |
AU2013204842B2 (en) | Electrochemical test strip | |
KR20110046307A (en) | Test meter for use with a dual chamber, multi-analyte test strip with opposing electrodes | |
KR20110046304A (en) | Dual chamber multi-analyte test strip with opposite electrode | |
US20090032395A1 (en) | Biosensor |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
AS | Assignment |
Owner name: BIOMEDIX TAIWAN, TAIWAN Free format text: ASSIGNMENT OF ASSIGNORS INTEREST;ASSIGNOR:CHO, CHING-HSIN;REEL/FRAME:015635/0268 Effective date: 20050111 Owner name: BIOMEDIX, INC., CALIFORNIA Free format text: ASSIGNMENT OF ASSIGNORS INTEREST;ASSIGNOR:CHO, CHING-HSIN;REEL/FRAME:015635/0268 Effective date: 20050111 |
|
REMI | Maintenance fee reminder mailed | ||
LAPS | Lapse for failure to pay maintenance fees | ||
STCH | Information on status: patent discontinuation |
Free format text: PATENT EXPIRED DUE TO NONPAYMENT OF MAINTENANCE FEES UNDER 37 CFR 1.362 |
|
FP | Lapsed due to failure to pay maintenance fee |
Effective date: 20100725 |