US7922707B2 - Devices and method for the penetration of a container stopper - Google Patents
Devices and method for the penetration of a container stopper Download PDFInfo
- Publication number
- US7922707B2 US7922707B2 US11/156,311 US15631105A US7922707B2 US 7922707 B2 US7922707 B2 US 7922707B2 US 15631105 A US15631105 A US 15631105A US 7922707 B2 US7922707 B2 US 7922707B2
- Authority
- US
- United States
- Prior art keywords
- spike
- container
- cassette
- reagent cassette
- accordance
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active, expires
Links
Images
Classifications
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
- B01L3/02—Burettes; Pipettes
- B01L3/0289—Apparatus for withdrawing or distributing predetermined quantities of fluid
- B01L3/0293—Apparatus for withdrawing or distributing predetermined quantities of fluid for liquids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M25/00—Catheters; Hollow probes
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B67—OPENING, CLOSING OR CLEANING BOTTLES, JARS OR SIMILAR CONTAINERS; LIQUID HANDLING
- B67C—CLEANING, FILLING WITH LIQUIDS OR SEMILIQUIDS, OR EMPTYING, OF BOTTLES, JARS, CANS, CASKS, BARRELS, OR SIMILAR CONTAINERS, NOT OTHERWISE PROVIDED FOR; FUNNELS
- B67C3/00—Bottling liquids or semiliquids; Filling jars or cans with liquids or semiliquids using bottling or like apparatus; Filling casks or barrels with liquids or semiliquids
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
- B01L2200/16—Reagents, handling or storing thereof
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2300/00—Additional constructional details
- B01L2300/06—Auxiliary integrated devices, integrated components
- B01L2300/0672—Integrated piercing tool
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
- G01N35/10—Devices for transferring samples or any liquids to, in, or from, the analysis apparatus, e.g. suction devices, injection devices
- G01N35/1079—Devices for transferring samples or any liquids to, in, or from, the analysis apparatus, e.g. suction devices, injection devices with means for piercing stoppers or septums
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S604/00—Surgery
- Y10S604/905—Aseptic connectors or couplings, e.g. frangible, piercable
Definitions
- the present invention relates generally to devices and methods for penetrating stoppers. More specifically, the present invention is directed to an improved spike for a reagent cassette.
- Medical drugs, reagents and other substances are often supplied in metal, glass or plastic containers. These containers have a hollow body connected to a neck which has a radially extending flange.
- the neck has a central passage which extends in the longitudinal direction of the container from the flange to the inside of the body.
- the central passage in the neck may be sealed by a rubber, plastic or other elastomeric stopper or septum.
- the stopper may be retained by a retaining band folded over the flange, or a screw top, or shrink wrapping, or welding or the like.
- the stopper usually has a thin central portion which facilitates insertion of a cannula or hollow spike though the stopper.
- the word “spike” will be used in this application to denote any device intended to pierce the stopper of a container and provide a passage which the contents of the container may travel through.
- the thin portion of the stopper is surrounded by a thick portion which is in contact with, and seals against, the inside wall of the central passage.
- a retaining cap is used then it may be provided with a central opening aligned with the passage.
- a reagent cassette spike is made of a semi rigid polymer for example a polyolefin such as polypropylene, polyethylene or polycarbonate, and in particular if the passage in the neck of the container is narrow which necessitates a correspondingly thin spike, then during automated spiking, the spike may fail to penetrate cleanly though the thin portion of the stopper and instead bends to one side. It may come to rest in the thicker portion of the stopper, thereby blocking the spike and preventing extraction of the contents of the container.
- FIG. 1 b shows an example of a spike incorrectly inserted in a stopper.
- the present invention provides a spike for penetrating a container stopper, wherein the spike has an elongated body defining a longitudinal bore.
- the body also includes a blunt tip.
- the present invention also provides a reagent cassette which includes at least one spike of the present invention for penetrating a stopper.
- the present invention further provides a method for penetrating the stopper of a container insertable into a reagent cassette.
- the method includes the steps of a) providing a reagent cassette with a spike of the present invention, b) aligning the longitudinal axis of the stopper with the longitudinal axis of the spike, and c) moving the spike and stopper towards each other until the spike has penetrated the stopper.
- the present invention still further provides an improved spike.
- the spike includes a free end, a fixed end, and an elongate hollow body extending between.
- the body defines a longitudinal passageway there through as well as an aperture in fluid communication with and extending transversely to the passageway.
- the improvement includes forming the free end of the body to have a substantially flat surface extending transversely to the longitudinal axis of the body.
- the present invention provides an improvement to a cassette adaptable to be received by a automated synthesis unit.
- the cassette includes an elongate body accommodating components of fluid circuitry.
- the body also defines at least one receptacle for receiving a container having a puncturable cap.
- the receptacle includes a spike for puncturing the puncturable cap of the container so as to render the interior of the container in fluid communication with at least a part of the fluid circuitry.
- the improvement includes providing a spike including a blunt tip which is symmetrical about the longitudinal axis of the spike for penetrating puncturable stopper.
- FIG. 1 a shows schematically a successful insertion of a spike of the prior art through a stopper
- FIG. 1 b shows schematically an unsuccessful insertion of a spike of the prior art through a stopper
- FIG. 2 a shows schematically a cross-section though a portion of a reagent cassette comprising a plurality of a spike of the prior art
- FIG. 2 b shows schematically a plan view of the portion of the reagent cassette of FIG. 2 a );
- FIG. 3 shows a portion of an embodiment of a reagent cassette comprising a spike in accordance with one embodiment of the present invention
- FIG. 4 shows a portion of an embodiment of a reagent cassette comprising a spike in accordance with a further embodiment of the present invention
- FIGS. 5 a )- 5 d show examples of possible spike transverse cross-sections
- FIGS. 6 a ) and 6 b ) show plan views of examples of possible spikes.
- FIG. 7 shows a perspective view of a reagent cassette in accordance with an embodiment of the present invention.
- FIG. 1 a shows schematically a perspective view of a successful insertion of a polyolefin spike 1 through a stopper 37 .
- Spike 1 has an elongated tubular body 5 with a bevelled tip 7 .
- Stopper 37 has a circular shape and has a thin central portion 9 of diameter S, a thin peripheral portion 11 and a thicker intermediate portion 13 between the central and peripheral portions 9 , 11 .
- the bevelled tip 7 has passed in a vertical straight line through the thin central portion 9 of the stopper 37 and the tip 7 is exposed.
- FIG. 1 b shows schematically a perspective view of an unsuccessful insertion of a spike 1 through a stopper 37 .
- the bevelled tip 7 has been deflected off a vertical path through the central portion 9 . Instead, it has followed a curved path which has resulted in the tip 7 becoming embedded in the thicker intermediate portion 13 of the stopper.
- FIG. 2 a shows schematically a cross-section though a portion of a reagent cassette 21 comprising a plurality of polyolefin spikes 3 .
- Cassette 21 comprises a plurality of reagent container receiving chambers 23 , each of which is surrounded by a wall 25 .
- the base 27 of each chamber supports a centrally positioned spike 3 of outer diameter D and height H that projects along the central axis of the chamber towards the opposite, open end 29 of the chamber 23 .
- Each spike 3 has a central bore 31 of diameter d which extends the whole length of the spike, though the base 27 of the reagent container receiving chamber and opens out into a valve 33 .
- Valve 33 can be used to control the movement of fluids in central bore 31 .
- a reagent container 35 is shown in dotted lines positioned in a reagent container receiving chamber 23 .
- the size and shape of reagent container 35 and the size and shape of reagent container receiving chamber 23 are adapted so that reagent container 35 fits concentrically into reagent container receiving chamber 23 and is retained by friction between the reagent container and container wall 25 .
- Container 35 has neck 36 with an inner diameter N which is greater than the outer diameter D of spike 3 .
- Neck 36 is sealed by a stopper 37 .
- the distance from outer surface of the stopper to the interior of the container is less than the height H of a spike 3 .
- the tip 7 of each spike which is intended to pierce a stopper 37 is bevelled at an angle ⁇ ° to form a sharp tip 7 with an inclined surface 39 which is inclined at the angle ⁇ ° to the longitudinal axis of the spike.
- FIG. 3 shows schematically a cross-section through a portion of a reagent cassette 41 comprising a plurality of semi-rigid spikes 43 , made from, for example, polyolefins, in accordance with a first embodiment of the present invention.
- spikes 43 have open blunt tips 47 which are intended to penetrate the stopper 37 of a container—the end surface 49 of each tip 47 is substantially flat and arranged to be substantially perpendicular to the longitudinal axis of the elongated body 5 and has a central opening 45 communicating with central bore 31 .
- FIG. 4 shows schematically a cross-section through a portion of a reagent cassette 51 comprising a plurality of spikes 53 in accordance with a second embodiment of the present invention.
- spikes 53 have solid blunt tips 57 which are intended to penetrate the stopper of a container—the end surface 59 of each tip 57 is substantially flat, has no opening and is arranged to be substantially perpendicular to the longitudinal axis of the body 5 .
- each spike is provided with at least one lateral opening, for example a rectangular slit 61 , which extends in the longitudinal direction of the spike from behind the solid tip 57 towards the opposite end of the spike and is in fluid communication with the central bore 31 blocked by solid end surface 59 .
- each opening is adapted so that when the spike is inserted though a container stopper to its maximum depth, the whole of the opening is exposed to the interior of the container.
- each spike has two, three, four or more than four openings. Openings can be any shape, for example rectangular, square, round, oval.
- the stopper of a reagent container can be penetrated in a reagent cassette in accordance with the present invention by placing the container in a container receiving chamber of the cassette with the stopper facing towards the spike, the longitudinal axis of the stopper being substantially aligned with the longitudinal axis of the spike, and then pressing the container towards the base of the chamber. As the container moves towards the base of the chamber, the blunt tip of the spike penetrates the stopper. The movement of the container is continued until the opening in the spike has penetrated all the way through the stopper and is exposed to the contents of the container.
- FIGS. 5 a )- 5 d ) shows a selection of further possible embodiments of spike cross-sections—quadratic, quadratic with rounded corners, octagonal and hexagonal respectively.
- Other cross-sections are also possible, preferably they are symmetrical about the longitudinal axis of the spike so that during penetration of a stopper by the spike the occurrence of undesirable lateral forces (that is forces perpendicular to the direction of relative movement between the stopper and spike) is avoided.
- FIG. 6 a shows an enlarged schematic plan view of a further embodiment of a spike in which the spike tip 77 has a reinforcing transverse rib 79 that extends from one side 81 of the bore 5 to the diametrically opposite side 83 .
- FIG. 6 shows an enlarged schematic plan view of a further embodiment of a spike in which the spike tip 87 has two, mutually perpendicular reinforcing transverse ribs 89 A, 89 B, each of which extends from one side of the bore 5 to the diametrically opposite side. While the above two embodiments of bores provided with reinforcing ribs have been illustrated with bores and tips with circular cross-sections, it is conceivable to use such ribs with bores and tips of any cross-sectional shape.
- FIG. 7 shows a perspective view of a reagent cassette 21 in accordance with an embodiment of the present invention.
- Reagent cassette 21 is intended to be used in an automated synthesis (not shown) unit provided with automated actuators.
- Reagent cassette 21 is cooperatively received in, engaged by, and operated by the automated synthesis unit.
- the automated synthesis unit cooperates with cassette 21 to produce various pharmaceutical or chemical products.
- Cassette 21 has elongate body 210 which provides various components of fluid circuitry such as valves 212 , conduit tubing 214 , and actuator plungers 216 .
- the valves 212 are desirable formed as taught in copending U.S. patent application Ser. No. 11/010142, entitled “Method and apparatus for the distribution of fluids”, the entire contents of which are herein incorporated by reference as if fully disclosed herein.
- Body 210 defines a plurality of receptacles 220 for cooperatively receiving containers, eg, 222 which provide or accommodate contents used during a synthesis run.
- each receptacle 220 includes a blunt spike 226 (shown in phantom lines) for penetrating the puncturable cap 224 received therein.
- Each blunt spike 226 used provides the contents of the containers in fluid communication with the components of the fluid circuitry so as to be directable at the command of the automated synthesis unit. It has been found that incorporating the spike 226 of the present invention, cassette 21 increases operation reliability when producing product with the automated synthesis unit.
- spike 226 with a blunt end 228 which is symmetrical about the longitudinal axis X-X of the spike body 230 , insertion of spike 226 through cap 224 does not tend to deflect off the axis X-X.
- Blunt end 228 desirably includes a solid planar end face 232 which extends transversely to axis X-X.
- the diameter or width of the central bore of the spike is equal to half the maximum diameter or width of the spike. In a more preferable embodiment of the present invention the diameter or width of the central bore of the spike is less than half the maximum diameter or width of the spike. Preferably the maximum width or diameter of a spike is at least 2 mm and less than 10 mm. Additionally it is preferable that the length of a spike is less than 10 times its maximum width or diameter and more preferably less than 5 times its maximum width or diameter.
- spikes in accordance with the present invention can be used in other device where a spike has to penetrate a stopper.
Abstract
Description
Claims (14)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GB0506057.9 | 2005-03-24 | ||
GB0506057A GB2424417B (en) | 2005-03-24 | 2005-03-24 | Devices and method for the penetration of a container stopper |
Publications (2)
Publication Number | Publication Date |
---|---|
US20060229584A1 US20060229584A1 (en) | 2006-10-12 |
US7922707B2 true US7922707B2 (en) | 2011-04-12 |
Family
ID=34566430
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
US11/156,311 Active 2026-10-24 US7922707B2 (en) | 2005-03-24 | 2005-06-17 | Devices and method for the penetration of a container stopper |
Country Status (5)
Country | Link |
---|---|
US (1) | US7922707B2 (en) |
CN (1) | CN2853079Y (en) |
DE (1) | DE202005009539U1 (en) |
FR (1) | FR2883554B1 (en) |
GB (1) | GB2424417B (en) |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
USD939958S1 (en) * | 2019-01-10 | 2022-01-04 | air up group GmbH | Bottle spout |
Families Citing this family (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN102205593A (en) * | 2011-01-31 | 2011-10-05 | 江苏华兰药用新材料股份有限公司 | Method for preparing rubber stopper without die-splitting side |
CN104107733B (en) * | 2013-04-16 | 2016-01-20 | 深圳迈瑞生物医疗电子股份有限公司 | A kind of reagent bottle and reagents loaded device and method thereof |
Citations (27)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4236520A (en) | 1978-12-04 | 1980-12-02 | Anderson Mark L | Fluid drain or injection tube for an animal's udder |
US4534465A (en) * | 1983-10-13 | 1985-08-13 | Coulter Electronics, Inc. | Cassette for supporting test tubes of different diameters and/or lengths |
US4582223A (en) * | 1982-08-02 | 1986-04-15 | The Coca-Cola Company | Syrup supply method and apparatus for a post-mix beverage dispenser |
US4834152A (en) * | 1986-02-27 | 1989-05-30 | Intelligent Medicine, Inc. | Storage receptacle sealing and transfer apparatus |
US4838877A (en) | 1985-08-06 | 1989-06-13 | Massau Bruce A | Polymeric hypodermic device |
US4959053A (en) * | 1988-01-08 | 1990-09-25 | Jang Cheng Houng | Automatic stopping device for the intravenous drip |
US5037390A (en) * | 1989-12-28 | 1991-08-06 | Kenneth Raines | System and method for mixing parenteral nutrition solutions |
US5279576A (en) * | 1992-05-26 | 1994-01-18 | George Loo | Medication vial adapter |
US5324483A (en) * | 1992-10-08 | 1994-06-28 | Warner-Lambert Company | Apparatus for multiple simultaneous synthesis |
US5423753A (en) * | 1993-06-30 | 1995-06-13 | Baxter International Inc. | Vial adapter |
US5478328A (en) | 1992-05-22 | 1995-12-26 | Silverman; David G. | Methods of minimizing disease transmission by used hypodermic needles, and hypodermic needles adapted for carrying out the method |
US5509912A (en) * | 1994-10-24 | 1996-04-23 | Vlv Associates | Connector |
US5531672A (en) * | 1987-07-31 | 1996-07-02 | Lawrence A. Lynn | Blood aspiration assembly components and blunt needle aspirators |
US5609826A (en) * | 1995-04-17 | 1997-03-11 | Ontogen Corporation | Methods and apparatus for the generation of chemical libraries |
US5848996A (en) | 1995-02-15 | 1998-12-15 | Eldor; Joseph | Multiple hole spinal needle |
US5976470A (en) * | 1998-05-29 | 1999-11-02 | Ontogen Corporation | Sample wash station assembly |
US6032812A (en) | 1996-07-22 | 2000-03-07 | Crealise Packaging Inc. | One-piece cap for liquid dispenser container |
US6126904A (en) * | 1997-03-07 | 2000-10-03 | Argonaut Technologies, Inc. | Apparatus and methods for the preparation of chemical compounds |
US6221056B1 (en) | 1996-12-20 | 2001-04-24 | David G. Silverman | Strong diaphragm/safe needle units and components for transfer of fluids |
US6319399B1 (en) * | 1999-06-24 | 2001-11-20 | Dialysis Systems, Inc. | Isolation block |
US6398956B1 (en) * | 1999-05-28 | 2002-06-04 | Bio/Data Corporation | Method and apparatus for directly sampling a fluid for microfiltration |
US6485690B1 (en) * | 1999-05-27 | 2002-11-26 | Orchid Biosciences, Inc. | Multiple fluid sample processor and system |
US6527758B2 (en) * | 2001-06-11 | 2003-03-04 | Kam Ko | Vial docking station for sliding reconstitution with diluent container |
US6783732B2 (en) * | 1998-10-29 | 2004-08-31 | Applera Corporation | Apparatus and method for avoiding cross-contamination due to pendent drops of fluid hanging from discharge conduits |
US20040254541A1 (en) * | 2003-04-21 | 2004-12-16 | K. C. Wong | Non-sharp vascular infusion cannula |
US7341872B1 (en) * | 2004-04-29 | 2008-03-11 | Uop Llc | Multiautoclave with set of vessels for combinatorial synthesis of zeolites and other materials |
US20080156377A1 (en) * | 2006-12-29 | 2008-07-03 | Brad Mann | Recovery system |
-
2005
- 2005-03-24 GB GB0506057A patent/GB2424417B/en active Active
- 2005-06-17 CN CNU200520011889XU patent/CN2853079Y/en not_active Expired - Lifetime
- 2005-06-17 US US11/156,311 patent/US7922707B2/en active Active
- 2005-06-17 DE DE200520009539 patent/DE202005009539U1/en not_active Expired - Lifetime
- 2005-06-28 FR FR0551802A patent/FR2883554B1/en active Active
Patent Citations (29)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4236520A (en) | 1978-12-04 | 1980-12-02 | Anderson Mark L | Fluid drain or injection tube for an animal's udder |
US4582223A (en) * | 1982-08-02 | 1986-04-15 | The Coca-Cola Company | Syrup supply method and apparatus for a post-mix beverage dispenser |
US4534465A (en) * | 1983-10-13 | 1985-08-13 | Coulter Electronics, Inc. | Cassette for supporting test tubes of different diameters and/or lengths |
US4838877A (en) | 1985-08-06 | 1989-06-13 | Massau Bruce A | Polymeric hypodermic device |
US4834152A (en) * | 1986-02-27 | 1989-05-30 | Intelligent Medicine, Inc. | Storage receptacle sealing and transfer apparatus |
US5531672A (en) * | 1987-07-31 | 1996-07-02 | Lawrence A. Lynn | Blood aspiration assembly components and blunt needle aspirators |
US4959053A (en) * | 1988-01-08 | 1990-09-25 | Jang Cheng Houng | Automatic stopping device for the intravenous drip |
US5037390A (en) * | 1989-12-28 | 1991-08-06 | Kenneth Raines | System and method for mixing parenteral nutrition solutions |
US5478328A (en) | 1992-05-22 | 1995-12-26 | Silverman; David G. | Methods of minimizing disease transmission by used hypodermic needles, and hypodermic needles adapted for carrying out the method |
US5279576A (en) * | 1992-05-26 | 1994-01-18 | George Loo | Medication vial adapter |
US5324483A (en) * | 1992-10-08 | 1994-06-28 | Warner-Lambert Company | Apparatus for multiple simultaneous synthesis |
US5324483B1 (en) * | 1992-10-08 | 1996-09-24 | Warner Lambert Co | Apparatus for multiple simultaneous synthesis |
US5423753A (en) * | 1993-06-30 | 1995-06-13 | Baxter International Inc. | Vial adapter |
US5509912A (en) * | 1994-10-24 | 1996-04-23 | Vlv Associates | Connector |
US5848996A (en) | 1995-02-15 | 1998-12-15 | Eldor; Joseph | Multiple hole spinal needle |
US5609826A (en) * | 1995-04-17 | 1997-03-11 | Ontogen Corporation | Methods and apparatus for the generation of chemical libraries |
US6032812A (en) | 1996-07-22 | 2000-03-07 | Crealise Packaging Inc. | One-piece cap for liquid dispenser container |
US6221056B1 (en) | 1996-12-20 | 2001-04-24 | David G. Silverman | Strong diaphragm/safe needle units and components for transfer of fluids |
US6126904A (en) * | 1997-03-07 | 2000-10-03 | Argonaut Technologies, Inc. | Apparatus and methods for the preparation of chemical compounds |
US6416718B1 (en) * | 1998-05-29 | 2002-07-09 | Ontogen Corporation | Sample wash station assembly |
US5976470A (en) * | 1998-05-29 | 1999-11-02 | Ontogen Corporation | Sample wash station assembly |
US6783732B2 (en) * | 1998-10-29 | 2004-08-31 | Applera Corporation | Apparatus and method for avoiding cross-contamination due to pendent drops of fluid hanging from discharge conduits |
US6485690B1 (en) * | 1999-05-27 | 2002-11-26 | Orchid Biosciences, Inc. | Multiple fluid sample processor and system |
US6398956B1 (en) * | 1999-05-28 | 2002-06-04 | Bio/Data Corporation | Method and apparatus for directly sampling a fluid for microfiltration |
US6319399B1 (en) * | 1999-06-24 | 2001-11-20 | Dialysis Systems, Inc. | Isolation block |
US6527758B2 (en) * | 2001-06-11 | 2003-03-04 | Kam Ko | Vial docking station for sliding reconstitution with diluent container |
US20040254541A1 (en) * | 2003-04-21 | 2004-12-16 | K. C. Wong | Non-sharp vascular infusion cannula |
US7341872B1 (en) * | 2004-04-29 | 2008-03-11 | Uop Llc | Multiautoclave with set of vessels for combinatorial synthesis of zeolites and other materials |
US20080156377A1 (en) * | 2006-12-29 | 2008-07-03 | Brad Mann | Recovery system |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
USD939958S1 (en) * | 2019-01-10 | 2022-01-04 | air up group GmbH | Bottle spout |
Also Published As
Publication number | Publication date |
---|---|
FR2883554A1 (en) | 2006-09-29 |
CN2853079Y (en) | 2007-01-03 |
GB2424417B (en) | 2008-11-12 |
GB0506057D0 (en) | 2005-05-04 |
DE202005009539U1 (en) | 2005-10-06 |
US20060229584A1 (en) | 2006-10-12 |
FR2883554B1 (en) | 2015-04-24 |
GB2424417A (en) | 2006-09-27 |
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