US8450347B2 - Composition for relieving discomfort - Google Patents
Composition for relieving discomfort Download PDFInfo
- Publication number
- US8450347B2 US8450347B2 US12/033,379 US3337908A US8450347B2 US 8450347 B2 US8450347 B2 US 8450347B2 US 3337908 A US3337908 A US 3337908A US 8450347 B2 US8450347 B2 US 8450347B2
- Authority
- US
- United States
- Prior art keywords
- vitamin
- per
- tryptophan
- composition
- protein
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related, expires
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/02—Nutrients, e.g. vitamins, minerals
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs
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- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S426/00—Food or edible material: processes, compositions, and products
- Y10S426/801—Pediatric
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Abstract
Description
TABLE 1 | |
Amounts per 100 kcal product |
Component | Range | Preferred range |
Digestible carbohydrates | 4-25 | 6-22 | g |
Folic acid | 44-4000 | 50-2000 | μg |
Vitamin B12 | 0.8-2000 | 1-1000* | μg |
Vitamin B6 | 50-10000 | 60-2000 | μg |
Riboflavin | 0.08-20 | 0.14-6 | mg |
Thiamine | 55-8000 | 70-4000 | μg |
Niacin | 0.55-60 | 1.4-25 | mg niacin equivalents |
Vitamin K | >8 | 30-90 | μg |
Taurine | 5-100 | 7-50 | mg |
Betaine | 30-4000 | 50-600 | mg |
Magnesium | 5-400 | 8-200 | mg |
Zinc | 0.8-100 | 1-30 | mg |
Mg + Zn/Ca | >0.08 | >0.10 | m/m |
Mg + Zn/P | >0.20 | >0.26 | m/m |
Melatonin | 30-3000 | 60-800 | mg |
Tryptophan | 0.05-8 | 0.2-2* | g |
Adenosine | 1-1000 | 50-500 | mg |
Methionine | 50-1000 | 100-500 | mg |
Note | |||
*higher doses should preferably be given as a multi-unit serving of smaller doses. |
Infant Formulae
-
- improves feelings of well being by the infants,
- supporting regular eating and sleeping patterns
- helps to compensate for insufficient capacity of the metabolic systems, especially in the young infant
- decreases the prevalence of hyperbilirubinaemia
- decreases the allergic reaction in the young infant, in particular atopic reactions caused by non-food allergens.
- decreases postprandial plasma levels of phenylalanine in phenylketonuria patients
- consumption of these formulae results in plasma levels of amino acids that are more similar to those of infants, that are exclusively fed with human breast milk, compared to consumption of conventional formulae
- does not give negative side effects to the infant
- therefore improves health and immune status and supports growth of high quality
- has an excellent taste and can be produced at acceptable costs.
TABLE 2 |
Composition of liquid infant formula |
Values are in mg per 100 ml, except where indicated differently. |
Protein (60% sweet whey, 40% casein) | 1400 | |
Added Trp | 10 | |
Added Arg | 10 | |
Lactose | 7500 | |
Maltodextrins (10-15 DE) | 1600 | |
Fat (EP-231904) | 3100 | |
Na | 18-25 | |
K | 60-100 | |
Cl | 40-60 | |
Ca | 50-85 | |
P | 20-50 | |
Mg | 4.5-6 | |
Fe | 0.5-0.9 | |
Zn | 0.6-1.3 |
Cu | 40-60 | μg | |
Mn | 5-20 | μg | |
Se | 1.5-2.2 | μg | |
I | 5-15 | μg | |
Vitamin A | 80-90 | RE | |
β-Carotene | 0-40 | μg | |
Vitamin D | 1-1.6 | μg | |
Vitamin E | 0.8-1.4 | mg TE | |
Vitamin K | 4-20 | μg | |
Thiamine | 35-45 | μg | |
Riboflavin | 110-150 | μg | |
Niacin | 0.7-1.0 | mg NE | |
Pantothenate | 0.25-0.35 | ||
Biotin | 1.5-1.7 | μg |
Ascorbic acid | 5-10 | |
Taurine | 4-7 |
Folic acid (added as monoglutamate) | 25-32 | μg | |
Vitamin B12 (added as hydroxycobalamine) | 0.4-0.7 | μg | |
Vitamin B6 (added as pyridoxine) | 50-65 | μg | |
-
- 2.0 kg alpha-lactalbumin
- 50 mg melatonin
- 100 mg folic acid monoglutamate
- 25 mg cyanocobalamin
- 100 mg pyridoxal
- 100 mg riboflavin
- 60 mg thiamine.HCl
- 30 g zinc chloride. 12H2O
-
- 9.5 kg Maltodextrin
- 100 mg folic acid
- 25 mg vit. B12
- 100 mg B6
- 100 mg B2
- 60 mg B1
- 1.0 g niacin
- 100 g betaine
- 300 g magnesium chloride
- 30 g zinc chloride
- 50 g adenosine
- 100 mg Vitamin K.
Energy density | 20-65 | kcal/100 ml | |
Protein | 2-4 | g |
alpha-lactalbumin enriched (>40 wt %) whey fraction comprising |
2.3 wt % tryptophan |
Fat | 1-4 | g | |
Carbohydrate | 10-20 | g |
About 10 wt % ribose -, about 70 wt % glucose -, about 15% |
galactose - and about 5 wt % maltose source: sources are at |
least partially oligo-/polymeric, amounts are all calculated as |
monosaccharide |
Fiber | 0.5-5 | g | |
Folic acid | 400 | μg | |
Vitamin B12 | 4 | μg | |
Vitamin B6 | 4 | mg | |
Vitamin B1 | 2 | mg | |
Vitamin B3 (niacin) | 36 | mg | |
Vitamin K | 160 | mg | |
Vitamin A | 180 | μg | |
Vitamin D | 1.28 | μg | |
Vitamin B2 | 0.5 | mg | |
Vitamin B5 (pantothenic acid) | 1.5 | mg | |
Biotin | 7.5 | μg | |
Vitamin C | 22 | mg | |
Iron | 3.8 | mg | |
Zinc | 7 | mg | |
Copper | 1.0 | mg | |
Manganese | 0.6 | mg | |
Molybdenum | 11.8 | μg | |
Selenium | 10 | μg | |
Chromium | 9.2 | μg | |
Iodine | 35 | μg | |
Calcium | 266 | mg | |
Phosphorus | 186 | mg | |
Magnesium | 120 | mg | |
Sodium | 30-180 | mg | |
Potassium | 80-300 | mg | |
Chloride | 30-180 | mg | |
Betaine | 200 | mg | |
Claims (16)
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US12/033,379 US8450347B2 (en) | 1999-01-20 | 2008-02-19 | Composition for relieving discomfort |
Applications Claiming Priority (10)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP99200166 | 1999-01-20 | ||
EP99200166.9 | 1999-01-20 | ||
EP99200166 | 1999-01-20 | ||
EP99201359A EP0951842B1 (en) | 1999-01-20 | 1999-04-29 | Infant formula |
EP99201359 | 1999-04-29 | ||
EP99201359.9 | 1999-04-29 | ||
US09/889,793 US6900180B1 (en) | 1999-01-20 | 2000-01-20 | Pharmaceutical compositions for alleviating discomfort |
PCT/NL2000/000042 WO2000043013A1 (en) | 1999-01-20 | 2000-01-20 | Pharmaceutical compositions for alleviating discomfort |
US11/125,201 US8124585B2 (en) | 1999-01-20 | 2005-05-10 | Composition for relieving discomfort |
US12/033,379 US8450347B2 (en) | 1999-01-20 | 2008-02-19 | Composition for relieving discomfort |
Related Parent Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
US11/125,201 Division US8124585B2 (en) | 1999-01-20 | 2005-05-10 | Composition for relieving discomfort |
Publications (2)
Publication Number | Publication Date |
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US20080145451A1 US20080145451A1 (en) | 2008-06-19 |
US8450347B2 true US8450347B2 (en) | 2013-05-28 |
Family
ID=26153242
Family Applications (4)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
US09/889,793 Expired - Lifetime US6900180B1 (en) | 1999-01-20 | 2000-01-20 | Pharmaceutical compositions for alleviating discomfort |
US09/889,691 Expired - Lifetime US6613367B1 (en) | 1999-01-20 | 2000-01-20 | Infant formula |
US11/125,201 Expired - Fee Related US8124585B2 (en) | 1999-01-20 | 2005-05-10 | Composition for relieving discomfort |
US12/033,379 Expired - Fee Related US8450347B2 (en) | 1999-01-20 | 2008-02-19 | Composition for relieving discomfort |
Family Applications Before (3)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
US09/889,793 Expired - Lifetime US6900180B1 (en) | 1999-01-20 | 2000-01-20 | Pharmaceutical compositions for alleviating discomfort |
US09/889,691 Expired - Lifetime US6613367B1 (en) | 1999-01-20 | 2000-01-20 | Infant formula |
US11/125,201 Expired - Fee Related US8124585B2 (en) | 1999-01-20 | 2005-05-10 | Composition for relieving discomfort |
Country Status (11)
Country | Link |
---|---|
US (4) | US6900180B1 (en) |
EP (2) | EP0951842B1 (en) |
JP (2) | JP2002535277A (en) |
AT (2) | ATE228779T1 (en) |
AU (2) | AU2466600A (en) |
CA (2) | CA2359592C (en) |
DE (2) | DE69904257T2 (en) |
DK (1) | DK0951842T3 (en) |
ES (2) | ES2187115T3 (en) |
PT (1) | PT951842E (en) |
WO (2) | WO2000042868A1 (en) |
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CA2627837C (en) | 2013-09-10 |
CA2359592C (en) | 2008-07-29 |
DE60019722T2 (en) | 2005-11-17 |
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US20080145451A1 (en) | 2008-06-19 |
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US6613367B1 (en) | 2003-09-02 |
EP0951842A2 (en) | 1999-10-27 |
WO2000043013A1 (en) | 2000-07-27 |
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