US8894607B2 - Tip configurations for multi-lumen catheter - Google Patents

Tip configurations for multi-lumen catheter Download PDF

Info

Publication number
US8894607B2
US8894607B2 US13/687,919 US201213687919A US8894607B2 US 8894607 B2 US8894607 B2 US 8894607B2 US 201213687919 A US201213687919 A US 201213687919A US 8894607 B2 US8894607 B2 US 8894607B2
Authority
US
United States
Prior art keywords
catheter
lumen
distal
lumens
proximal
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
US13/687,919
Other versions
US20130085436A1 (en
Inventor
Joseph Barrett
Dallen G. Herzog
Amir Orome
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
CR Bard Inc
Original Assignee
CR Bard Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by CR Bard Inc filed Critical CR Bard Inc
Priority to US13/687,919 priority Critical patent/US8894607B2/en
Publication of US20130085436A1 publication Critical patent/US20130085436A1/en
Priority to US14/104,739 priority patent/US9656041B2/en
Priority to US14/543,499 priority patent/US9839763B2/en
Application granted granted Critical
Publication of US8894607B2 publication Critical patent/US8894607B2/en
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Images

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M39/00Tubes, tube connectors, tube couplings, valves, access sites or the like, specially adapted for medical use
    • A61M39/02Access sites
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M1/00Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
    • A61M1/14Dialysis systems; Artificial kidneys; Blood oxygenators ; Reciprocating systems for treatment of body fluids, e.g. single needle systems for hemofiltration or pheresis
    • A61M1/16Dialysis systems; Artificial kidneys; Blood oxygenators ; Reciprocating systems for treatment of body fluids, e.g. single needle systems for hemofiltration or pheresis with membranes
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M1/00Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
    • A61M1/36Other treatment of blood in a by-pass of the natural circulatory system, e.g. temperature adaptation, irradiation ; Extra-corporeal blood circuits
    • A61M1/3621Extra-corporeal blood circuits
    • A61M1/3653Interfaces between patient blood circulation and extra-corporal blood circuit
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M1/00Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
    • A61M1/36Other treatment of blood in a by-pass of the natural circulatory system, e.g. temperature adaptation, irradiation ; Extra-corporeal blood circuits
    • A61M1/3621Extra-corporeal blood circuits
    • A61M1/3653Interfaces between patient blood circulation and extra-corporal blood circuit
    • A61M1/3656Monitoring patency or flow at connection sites; Detecting disconnections
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M1/00Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
    • A61M1/36Other treatment of blood in a by-pass of the natural circulatory system, e.g. temperature adaptation, irradiation ; Extra-corporeal blood circuits
    • A61M1/3621Extra-corporeal blood circuits
    • A61M1/3653Interfaces between patient blood circulation and extra-corporal blood circuit
    • A61M1/3659Cannulae pertaining to extracorporeal circulation
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M1/00Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
    • A61M1/36Other treatment of blood in a by-pass of the natural circulatory system, e.g. temperature adaptation, irradiation ; Extra-corporeal blood circuits
    • A61M1/3621Extra-corporeal blood circuits
    • A61M1/3653Interfaces between patient blood circulation and extra-corporal blood circuit
    • A61M1/3659Cannulae pertaining to extracorporeal circulation
    • A61M1/3661Cannulae pertaining to extracorporeal circulation for haemodialysis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M25/00Catheters; Hollow probes
    • A61M25/0021Catheters; Hollow probes characterised by the form of the tubing
    • A61M25/0023Catheters; Hollow probes characterised by the form of the tubing by the form of the lumen, e.g. cross-section, variable diameter
    • A61M25/0026Multi-lumen catheters with stationary elements
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M25/00Catheters; Hollow probes
    • A61M25/0021Catheters; Hollow probes characterised by the form of the tubing
    • A61M25/0023Catheters; Hollow probes characterised by the form of the tubing by the form of the lumen, e.g. cross-section, variable diameter
    • A61M25/0026Multi-lumen catheters with stationary elements
    • A61M25/003Multi-lumen catheters with stationary elements characterized by features relating to least one lumen located at the distal part of the catheter, e.g. filters, plugs or valves
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M25/00Catheters; Hollow probes
    • A61M25/0021Catheters; Hollow probes characterised by the form of the tubing
    • A61M25/0023Catheters; Hollow probes characterised by the form of the tubing by the form of the lumen, e.g. cross-section, variable diameter
    • A61M25/0026Multi-lumen catheters with stationary elements
    • A61M25/0032Multi-lumen catheters with stationary elements characterized by at least one unconventionally shaped lumen, e.g. polygons, ellipsoids, wedges or shapes comprising concave and convex parts
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M25/00Catheters; Hollow probes
    • A61M25/0067Catheters; Hollow probes characterised by the distal end, e.g. tips
    • A61M25/0068Static characteristics of the catheter tip, e.g. shape, atraumatic tip, curved tip or tip structure
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M39/00Tubes, tube connectors, tube couplings, valves, access sites or the like, specially adapted for medical use
    • A61M39/10Tube connectors; Tube couplings
    • A61M39/105Multi-channel connectors or couplings, e.g. for connecting multi-lumen tubes
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/14Infusion devices, e.g. infusing by gravity; Blood infusion; Accessories therefor
    • A61M5/1407Infusion of two or more substances
    • A61M5/1408Infusion of two or more substances in parallel, e.g. manifolds, sequencing valves
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M25/00Catheters; Hollow probes
    • A61M25/0021Catheters; Hollow probes characterised by the form of the tubing
    • A61M25/0023Catheters; Hollow probes characterised by the form of the tubing by the form of the lumen, e.g. cross-section, variable diameter
    • A61M25/0026Multi-lumen catheters with stationary elements
    • A61M25/003Multi-lumen catheters with stationary elements characterized by features relating to least one lumen located at the distal part of the catheter, e.g. filters, plugs or valves
    • A61M2025/0031Multi-lumen catheters with stationary elements characterized by features relating to least one lumen located at the distal part of the catheter, e.g. filters, plugs or valves characterized by lumina for withdrawing or delivering, i.e. used for extracorporeal circuit treatment
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M25/00Catheters; Hollow probes
    • A61M25/0021Catheters; Hollow probes characterised by the form of the tubing
    • A61M25/0023Catheters; Hollow probes characterised by the form of the tubing by the form of the lumen, e.g. cross-section, variable diameter
    • A61M25/0026Multi-lumen catheters with stationary elements
    • A61M2025/0036Multi-lumen catheters with stationary elements with more than four lumina
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M25/00Catheters; Hollow probes
    • A61M25/0067Catheters; Hollow probes characterised by the distal end, e.g. tips
    • A61M25/0068Static characteristics of the catheter tip, e.g. shape, atraumatic tip, curved tip or tip structure
    • A61M2025/0073Tip designed for influencing the flow or the flow velocity of the fluid, e.g. inserts for twisted or vortex flow
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2202/00Special media to be introduced, removed or treated
    • A61M2202/0021Special media to be introduced, removed or treated removed from and reintroduced into the body, e.g. after treatment
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2202/00Special media to be introduced, removed or treated
    • A61M2202/04Liquids
    • A61M2202/0413Blood
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M25/00Catheters; Hollow probes
    • A61M25/0067Catheters; Hollow probes characterised by the distal end, e.g. tips
    • A61M25/0068Static characteristics of the catheter tip, e.g. shape, atraumatic tip, curved tip or tip structure
    • A61M25/007Side holes, e.g. their profiles or arrangements; Provisions to keep side holes unblocked

Definitions

  • catheters with three or more lumens are needed to deliver and/or withdraw fluid from the patients' circulatory system.
  • the physician may need to divert blood from the circulatory system through a first lumen in the catheter and at the same time reintroduce the removed blood back into the circulatory system through a second lumen.
  • a third lumen in the catheter may be used to introduce medications and/or nutrition supplements.
  • each of the lumens within a multi-lumen catheter may be used to introduce a different drug into a patient's circulatory system. The use of separate lumens for each drug may prevent premature mixing of the medications.
  • a triple lumen catheter One common application of a triple lumen catheter is the use of the catheter for apheresis and for delivery of medications during chemotherapy treatment of a cancer patient.
  • Apheresis is a process that involves the removal of whole blood in a dialysis-like fashion. In this process, blood is circulated continuously from the patient to an instrument that acts as a centrifuge or filter, allowing for the separation of specific blood parts. The processed blood is re-circulated back into the patient's body.
  • apheresis may be utilized to separate out stem cells from the blood prior to chemotherapy treatments. This is generally accomplished by hormonally stimulating the production of bone marrow to produce a high number of stem cells.
  • the stem cells are separated from the rest of the blood parts using the triple lumen apheresis catheter. Chemotherapy drugs are then administered using a third lumen in the catheter. After a given length of Chemotherapy treatment time, the stem cells are infused back into the patient's circulatory system.
  • the triple lumen catheter may be inserted into the patient's subclavian vein that runs behind the clavicle to establish a central line.
  • the proximal end of the catheter may be tunneled under the skin for 2-4 inches to emerge from the chest close to the nipple.
  • the triple lumen catheter may be used for the collection of stem cells and for support of the patient during therapy.
  • antibiotics, anti-nausea medications, blood products, and fluids may also be infused through the implanted catheter.
  • a typical multi-lumen catheter tends to possess one or more of the following undesirable properties: high recirculation of blood, low flow rate for blood circulation and medication delivery, high phlebitis, and high tendency for aspirating lumen to suck against the vessel wall. These properties limit the catheter's efficiency in blood circulation and medication delivery, which could minimize the effectiveness of the medical intervention.
  • an improved multi-lumen catheter with high blood circulation efficiency and high throughput for medication delivery is desirable.
  • the improved design may incorporate one or more of the following performance characteristics: low recirculation of blood, high flow rates of blood and medications, high flow volume of blood and medications, low phlebitis, delivery of infusates in separate lumens, no dead end openings, limited sucking against vessel wall during aspiration, durable catheter structural design, capable of being produced in high volume, low production cost, capable of being placed over a guide-wire and/or a tunneler, and attractive appearance.
  • various multi-lumen catheters each having three or more lumens where at least two of the lumens have distal openings that are staggered along the length of the catheter.
  • the distal openings of the catheters are arranged in various configurations. These modified catheter configurations may improve fluid throughput efficiency and decrease recirculation in the catheter.
  • the catheter comprises a plurality of three or more lumens where the lumen openings at the distal portion of the catheter are staggered along the length of the catheter.
  • the lumens are angularly spaced apart and every one of the lumen openings directs the outflow in the axial direction toward the distal end of the catheter.
  • the lumens of the catheter may have a pie-shape cross-section with each lumen becoming narrower toward the axis of the catheter and widening toward the outer circumferential surface of the catheter.
  • the catheter comprises three staggered lumen openings in intervals of 2.5 cm. Each of two proximal lumens open at approximately a 150 degree angle with respect to one another, while a third lumen opens distally thereof.
  • the catheter comprises two or more lumens exiting at the distal end of the catheter, and at least one lumen exiting proximally along the length of the catheter.
  • the catheter comprises three lumens, with two of the three lumens exiting distally and the third lumen exiting proximally.
  • the third lumen is centrally located relative to the two other lumens.
  • the separation between the single proximal and the dual distal lumens may decrease the possibility of recirculation while maximizing flow rate.
  • the catheter may further comprise a beveled tip for increasing the catheter's ease of insertion while keeping infusates injected through the lumens separate until entering the high blood volume regions of the body.
  • the catheter comprises one distal lumen opening, and a plurality of proximal lumen openings.
  • the proximal lumens are grouped together along the length of the catheter.
  • the proximal lumen openings may be located at approximately the same axial location along the length of the catheter.
  • the catheter comprises a single lumen exiting at the distal end of the catheter and two other lumens terminating at the same plane along the length of the catheter proximal to the first lumen opening.
  • the two lumens with proximal openings are not offset angularly.
  • the two lumens may be angularly spaced when viewed from the distal end of the catheter.
  • FIG. 1A shows one variation of a triple lumen catheter with staggered lumen configuration.
  • all three lumens are staggered along the length of the catheter with the distance between the distal lumen opening and the mid-lumen opening being marked as L 1 , and the distance between the mid-lumen opening and the proximal lumen opening being marked as L 2 .
  • FIG. 1B shows the cross-sectional view of the catheter from FIG. 1A sectioned at the proximal portion of the catheter.
  • the interior of the catheter at the proximal end is divided into three pie-shape lumens.
  • FIG. 1C illustrates another variation of a triple lumen catheter where the walls of the two proximal lumens extend distally to form flanges around the lumen openings thereof.
  • FIG. 1D illustrates another design variation with a circular distal lumen and two proximal lumens staggered at intervals along the length of the catheter.
  • FIG. 1E shows the plain view of the catheter from FIG. 1D , viewed from the distal end of the catheter down the tubing axis.
  • the interior of the catheter at the distal portion comprises a circular lumen and two semi wedge/pie shape lumens.
  • FIG. 1F illustrates another variation of the staggered lumen design with a primary circular lumen opening and two staggered proximal lumen openings.
  • the two proximal lumens are configured with extended flanges at their distal openings.
  • FIG. 1G illustrates the cross-sectional view of the catheter from FIG. 1F at the proximal portion of the catheter.
  • FIG. 1H illustrates yet another variation of the triple lumen staggered design with side openings on the circumferential surface for providing additional fluid exits for the distal lumen.
  • FIG. 1I illustrates another variation of the staggered lumen design.
  • the two proximal lumens are configured with openings on the circumferential surface of the catheter.
  • FIG. 1J shows the cross-sectional view of the catheter from FIG. 1I at the proximal portion of the catheter.
  • FIG. 2A illustrates another variation of a triple lumen catheter with the stagger design.
  • the catheter comprises two distal lumens which are positioned side-by-side and one proximal lumen.
  • the distal lumens are designed with gradually expanding inner lumens.
  • FIG. 2B shows the frontal view of the catheter from FIG. 2A , as seen directly down the axis of the catheter with the two distal openings showing.
  • FIG. 2C shows the cross-sectional view of the catheter from FIG. 2A at the proximal portion of the catheter. As shown, the interior of the catheter at the proximal portion comprises three pie-shape lumens.
  • FIG. 2D shows another variation of the dual distal lumen design.
  • the distal end of the catheter is configured with a sharper profile as compared to the catheter shown in FIG. 2A .
  • FIG. 2E illustrates another variation of the dual distal lumen design where the lumens of the catheter extend linearly along the length of the catheter with constant lumen cross-sectional areas along the length of the catheter.
  • FIG. 2F shows the cross-sectional view of the catheter from FIG. 2E at the proximal portion of the catheter.
  • FIG. 2G illustrates another variation of the dual distal lumen design where the three lumens have varying shapes and cross-sectional areas.
  • FIG. 2H illustrates a plain view of the catheter from FIG. 2G , seen from the distal end of the catheter down the axial length of the catheter.
  • each of the three lumens has a semi-pie-shape cross-section.
  • FIG. 3A illustrates another variation of the stagger lumen design where the catheter comprises two proximal lumens positioned side-by-side and a distal lumen centrally positioned relative to the two proximal lumens.
  • FIG. 3B-1 shows the plain view of the catheter from FIG. 3A seen from the distal end of the catheter down the longitudinal axis of the catheter.
  • FIG. 3B-2 shows the cross-sectional view of the catheter from FIG. 3A at the proximal portion of the catheter.
  • FIG. 3C illustrates another variation of the dual proximal lumen design with a non-circular distal lumen.
  • FIG. 3D illustrates yet another variation of the dual proximal lumen design with side openings integrated on the circumferential surface of the catheter.
  • FIG. 3E illustrates another variation of a dual proximal lumen design where side openings are provided for accessing the distal lumen.
  • FIG. 3F illustrates one variation of a proximal end configuration for a triple lumen catheter.
  • FIG. 4A illustrates a plain view of one variation of a catheter with a single distal lumen and two proximal lumen configuration where a trifurcation is connected to the proximal end of the catheter.
  • FIG. 4B illustrates the distal portion of the catheter shown in FIG. 4A .
  • FIG. 4C illustrates the cross-sectional view of the trifurcation from the catheter system shown in FIG. 4A .
  • the figure illustrates the independent fluid communications provided by the three separate lumens.
  • FIG. 4D is the side view of the distal portion of the catheter shown in FIG. 4A .
  • FIG. 4E is the cross-sectional view of the distal portion of the catheter shown in FIG. 4D .
  • the cross-section is taken from the center of the catheter dividing the two proximal lumens.
  • FIG. 4F is the cross-section view at the proximal portion of the catheter shown in FIG. 4A .
  • FIG. 5A shows one variation of an access port having three independent cavities each of which has an independent fluid communication path to one of the lumens at the access port connection interface.
  • FIG. 5B illustrates an example of a triple lumen catheter with staggered lumen openings connected to an access port with three fluid cavities.
  • a triple lumen catheter is used herein as an example application to illustrate the various aspects of the invention disclosed herein. Variations of the inventions may comprise three or more lumens. It must also be noted that, as used in this specification and the appended claims, the singular forms “a,” “an” and “the” include plural referents unless the context clearly dictates otherwise. Thus, for example, the term “an opening” is intended to mean a single opening or a combination of openings, “a fluid” is intended to mean one or more fluids, or a mixture thereof.
  • the catheter comprises three or more lumens with staggered openings at the distal portion of the catheter which exit into the blood stream in intervals of predefined distance(s).
  • each of the lumens in the catheter has a separate opening at the distal end so that each of the lumens is in independent fluid communication with the interior of a blood vessel.
  • FIG. 1 illustrates one variation of the catheter 2 , with three lumens 4 , 6 , 8 .
  • the openings 12 , 14 , 16 for the three corresponding lumens 4 , 6 , 8 are staggered along the length of the catheter 2 .
  • L 1 The distance between the distal opening 12 and the middle opening 14 is indicated as “L 1 ”, and the distance between the middle opening 14 and the proximal opening 16 is indicated as “L 2 .”
  • L 1 may be larger, smaller, or equal to L 2 .
  • the staggered distance between the openings e.g., L 1 , L 2
  • the staggered distance between the openings is between about 0.5 cm to about 10 cm, more preferably between about 1 cm to about 5 cm, even more preferably between about 2 cm to about 3 cm, and most preferably about 2.5 cm.
  • the catheter may have four, five, six, seven or more lumens, each with a corresponding opening such that the openings are staggered along the length of the catheter in various configurations that are described herein. In some variations the staggered distances between the various openings are the same, in other variations the staggered distances between lumen openings may vary. Furthermore, although in the figures shown herein, each lumen has one opening at the distal portion of the catheter, one of ordinary skill would appreciate that each lumen in the catheter may be configured with additional openings.
  • the lumens 4 , 6 , 8 have pie-shaped cross-sectional areas. This non-circular lumen cross-sectional design may provide improved flow rate along the length of the catheter for the three lumens.
  • Each of the lumens 4 , 6 , 8 is bound by two interior walls and a portion of the outer catheter wall, and the two interior walls merge toward the central region of the catheter 2 .
  • the three interior walls may meet at the central axis of the catheter, or alternatively, they may meet off the central axis.
  • the first 22 and the second 26 interior walls form an angle “A 1 ”
  • the second 26 and the third 24 interior walls form an angle “A 2 ”
  • the third 24 and first 22 interior walls forms the angle “A 3 ”.
  • the inner walls between the lumens may be configured such that the interface angles A 1 , A 2 , A 3 may have various combinations.
  • the inner walls' arrangement at the proximal portion 30 of the catheter may be configured to match the corresponding walls at the distal portion of the catheter.
  • the three interior walls 22 , 24 , 26 separating the three lumens may have a distinct configuration in relation to the interior walls at the distal portion of the catheter.
  • the lumens at the proximal portion of the catheter may comprise of three cylindrically shaped lumens, and transition into three pie-shaped lumens at the distal portion of the catheter.
  • the three lumens 4 , 6 , 8 have the same cross-sectional area.
  • the lumen 4 with the distal opening and the lumen 8 with the proximal opening have the same cross-sectional area while the lumen 6 with the middle opening has a smaller cross-sectional area in comparison to the other two lumens 4 , 8 .
  • the catheter may be implemented for dialysis, where the lumen 8 with the proximal opening may be used to aspirate blood, while the lumen 4 with the distal opening may be used to infuse the processed blood and the third lumen 6 with a smaller opening may be used to infuse medications or nutrients into the patient.
  • the lumen 4 with the distal opening may have a larger cross-sectional area in relation to the other two lumens 6 , 8 , and the two proximal lumens 4 , 8 may have the same cross-sectional areas.
  • the three lumens 4 , 6 , 8 may have different cross-sectional areas.
  • the catheters may have different cross-sectional lumen shapes.
  • the lumens may have a circular or square shape instead of the pie-shapes described above.
  • any two of the three lumens on the catheter may be used for aspirating and infusing blood for dialysis or apheresis purposes, and the third lumen may be used independently for infusing fluids (e.g., saline, medications, nutrients, etc.) or extracting blood from the patient (e.g., taking blood samples).
  • the lumen used for aspirating blood has an opening that is proximal from the lumen used for infusing the processed/filtered blood.
  • the lumens used for aspiration and infusion of blood e.g., for filtering and/or processing
  • FIG. 1C illustrates another variation similar to the design shown in FIG. 1A ; however, the walls of the proximal lumens 6 , 8 have extended flanges 36 , 38 , 40 around their openings, which may direct blood flow and may provide a smoother surface profile for the catheter to minimize resistance and/or abrasion during insertion of the catheter into an orifice, such as a blood vessel.
  • theses extended flanges 36 , 38 , 40 may reduce stress concentration at transitions between profiles.
  • the catheter 2 comprises a primary lumen 4 that has a circular cross-section, while the two proximal lumens 6 , 8 have non-circular cross-sections.
  • the semi-pie-shaped lumens 6 , 8 allow one to provide two additional lumens around a primary circular lumen without significantly increasing the diameter of the overall catheter.
  • the frontal view of this catheter 2 seen from the distal end down the longitudinal axis of the catheter is shown in FIG. 1E .
  • the proximal portion of the catheter may be configured with three pie-shaped lumens similar to the one shown in FIG. 1B .
  • the two proximal lumens 6 , 8 open at approximately 110 to 170 degree angles with respect to each other. More preferably, the two proximal lumens 6 , 8 open at approximately 145 to 155 degree angles with respect to each other. And most preferably, the two proximal lumens 6 , 8 open at approximately 150 degree angles with respect to each other.
  • the catheter design with two proximal lumens 6 , 8 having this pie-shape/semi-pie-shape design may be implemented in a catheter having a circular or semicircular distal lumen 4 .
  • the two proximal lumens 6 , 8 having this pie-shape/semi-pie-shape design may be implemented in a catheter having the staggered lumen design described above, or in another design where the two proximal lumens are adjacent to one another along the length of the catheter. Such a design will be described in more detail below.
  • the staggered design may maximize the process efficiency by decreasing recirculation of previously apheresed blood at a preferred flow rate (about 120 ml/min), while allowing the infusion of medications or TPN (Total Parenteral Nutrition) through the third lumen at a preferred flow rate (e.g., equivalent flow of a 5 Fr single lumen PICC).
  • this design with one distal lumen formed centrally may be optimal for intravenous placement of the catheter via either a guidewire or tunneler, and may be produced in high volumes using radio frequency forming techniques.
  • FIG. 1F illustrates another design variation with a circular distal lumen opening and two proximal lumens openings 6 , 8 which are staggered along the length of the catheter.
  • the two proximal lumens 6 , 8 are configured with extending flanges 36 , 38 , 40 at their lumen openings.
  • the proximal portion 30 of the catheter 2 comprises three pie-shape lumens.
  • the opening for each of the lumens is positioned at the distal region of the corresponding lumen, and each of the lumen openings has an outflow direction towards the distal region of the catheter along the axis of the catheter.
  • the distal direction is shown as the Z-axis in FIG. 1A .
  • additional side openings may also be added along the length of the catheter to increase the fluid outflow and/or intake rate.
  • side openings 52 , 54 may be added to the distal portion 50 of the catheter 2 to facilitate fluid outflow from the distal lumen 4 , as shown in FIG. 1H .
  • the two proximal lumens of the catheter are configured with side openings 62 , 64 that open on the circumferential surface of the catheter as the primary inflow/outflow openings, as shown in FIG. 1I .
  • the catheter comprises three lumens.
  • the distal lumen 72 has a circular cross-section at the distal end 68 of the catheter.
  • the two proximal lumens are angularly positioned relative to each other, also shown in FIG. 1I .
  • the proximal openings 62 , 64 for the two proximal lumens 74 , 76 are staggered along the length of the catheter and are angularly displaced from each other.
  • the circumferential profile along the length of the catheter at the distal portion where the openings of the lumens are located is configured with a slightly tapered profile, such that the overall cross-sectional surface of the catheter decreases along the length of the catheter towards the distal end 68 of the catheter 2 .
  • the proximal portion of the catheter comprises three pie-shaped lumens.
  • the three pie-shaped lumens are of equal sizes, see FIG. 1J .
  • the catheter comprises three lumens 82 , 84 , 86 where two 82 , 84 of the three lumens 82 , 84 , 86 exit distally with a single centrally positioned lumen exiting proximally along the axial length of the catheter, as shown in FIGS. 2A , 2 D, 2 E, and 2 G.
  • the catheter may have a beveled tip to increase the catheter's ease of insertion.
  • the two independent lumens 82 , 84 at the distal end 88 allow the user to keep infusates separate until exiting the catheter into the blood stream of the patient.
  • the proximal lumen 86 may be used for aspirating blood out of the patient's circulatory system for apheresis or dialysis applications.
  • the separation between the single proximal lumen 86 and dual distal lumens 82 , 84 may minimize the recirculation while maximizing the flow rate.
  • the catheter is configured for 120 ml/min circulation rate (apheresis/dialysis flow rate) through one distal and one proximal lumen, and an equivalent flow rate of a 5 Fr PICC for the other distal lumen.
  • utilizing radio frequency forming techniques one may fabricate the catheters described above and achieve lumens with large cross-sectional areas.
  • Induction heating is observed when conductive materials are subjected to a radio frequency (RF) field.
  • RF energy induces eddy currents in a tipping die made of a conductive material, and heating occurs primarily by I 2 R heating, that is the power dissipation in a resistive circuit.
  • I 2 R heating that is the power dissipation in a resistive circuit.
  • the tipping die is also a magnetic material, additional heating effects occur from hysteresis heating, due to the friction created by the magnetic material's resistance to the rapidly changing magnetic field within the induction coil.
  • the tipping die is placed in an induction coil forming a solenoid and the die is heated by the energy transferred from the magnetic field.
  • the specific configuration of the solenoid may depend on the particular design requirement.
  • the forming temperature changes so that the thermoplastic tubing may be molded into the desired shape.
  • RF tipping technique such as the one described above may be implemented in the fabrication of the various catheters described herein.
  • the radio frequency forming techniques may allow efficient production of catheters that are reliable and have low incidence of breakage during use.
  • the radio frequency tipping process may allow inexpensive reproduction of catheters in large quantities in a high volume production process.
  • the two distal lumens 82 , 84 are configured such that the internal lumen cross-sections increase along the length of the catheter as they approach the distal end 88 of the catheter 2 .
  • the diameter of the two distal lumens 82 , 84 gradually increases along the length of the catheter 2 toward the distal end 88 of the catheter. This expansion in lumen diameter may allow the flow in the lumen of the catheter to have a decreased exit velocity in comparison to the fluid flow velocity along the proximal portion of the catheter where the cross-sectional area of the lumen is smaller.
  • FIG. 2A once the two distal lumens 82 , 84 pass the proximal lumen opening 90 , the diameter of the two distal lumens 82 , 84 gradually increases along the length of the catheter 2 toward the distal end 88 of the catheter. This expansion in lumen diameter may allow the flow in the lumen of the catheter to have a decreased exit velocity in comparison to the fluid flow velocity along the proximal portion of the catheter where the cross-section
  • the catheter is designed to have an overall diameter that is about the same along the length of the catheter 2 .
  • the catheter's overall cross-sectional area (perpendicular to the longitudinal axis of the catheter) at the distal dual openings 92 is slightly smaller than the overall cross-sectional area at the proximal portion 94 of the catheter.
  • FIG. 2B illustrates the frontal view (down the longitudinal axis) of the catheter as seen from the distal end 92 of the catheter 2
  • FIG. 2C illustrates the cross-sectional view of the catheter at the proximal portion 94 of the catheter 2 .
  • the distal portion 98 of the catheter may be configured with a larger cross-sectional area than the proximal portion 94 of the catheter.
  • FIG. 2D illustrates another example of a dual distal lumen design.
  • the distal end of the catheter 88 is configured with a sharper profile in comparison with the catheter shown in FIG. 2A .
  • the distal portion 98 of the catheter may be configured with a smaller cross-sectional area than the proximal portion 94 of the catheter.
  • the three lumens 82 , 84 , 86 of the catheter 2 may have constant cross-sectional areas along the length thereof, as shown in FIG. 2E .
  • the two walls 102 , 104 separating the two distal lumens 82 , 84 from the proximal lumen 86 continue linearly along the length of the catheter after passing the opening 90 of the proximal lumen 86 .
  • FIG. 2F illustrates the cross-sectional view of the catheter from its proximal portion.
  • the two distal lumens 82 , 84 have different cross-sectional areas.
  • the right distal lumen 82 is larger than the left distal lumen 84 at the distal portion of the catheter, as shown in FIG. 2H .
  • medications may be infused through either the right 82 or left 84 distal lumen, it may be preferable to infuse the processed blood through the larger lumen 82 to increase the blood filtering/processing rate.
  • the catheter 2 is designed with two proximal lumens 112 , 114 and one distal lumen 116 . Examples of this design are shown in FIGS. 3A , 3 C, 3 D and 3 F. This design may minimize recirculation due to the distance “x” (as shown in FIG. 3A ) between the two proximal 112 , 114 and one distal 116 lumen while simultaneously maximizing the flow rates and flow volumes.
  • the catheter may be configured for 120 ml/min circulatory flow rate at 250 mmHg through the distal and one proximal lumen, and an equivalent flow rate that is equal or better than 5 Fr PICC for the other proximal lumen.
  • the recirculation of the catheter is less than 5% at 120 ml/min.
  • the single distal lumen 116 may allow easy placement of the catheter 2 using a guidewire or tunneler through the distal lumen 116 .
  • Infusate such as medications, chemotherapy agents or nutrients may be delivered independently through one of the proximal lumens while the other proximal lumen may be used for aspiration of blood or for delivery of other fluids.
  • this design may be easily produced in high volume relatively inexpensively utilizing radio frequency techniques.
  • the catheter comprises a central lumen 116 with a circular cross-sectional area at the distal end, and two proximal lumens 112 , 114 with their openings 118 , 120 positioned side-by-side and proximal to the distal end 124 of the catheter.
  • the distance between the two proximal lumen openings 118 , 120 and the distal lumen opening 122 is indicated as “x”.
  • x is between about 1 cm to about 10 cm, more preferably about 2 cm to about 5 cm, even more preferably about 2 cm to about 3 cm, and most preferably about 2.5 cm. As shown in FIG.
  • the two proximal lumens 112 , 114 open at 120 degree angles with respect to each other.
  • the two proximal lumens may be designed to open at other angles (e.g., 150 degrees).
  • the cross-sectional areas of the lumen openings may be pie-shaped.
  • all three of the lumens 112 , 114 , 116 direct fluid flow to exit along the axial direction of the catheter toward a distal region beyond the catheter.
  • FIG. 3B-1 illustrates the frontal plain view of the catheter 2 seen from the distal end of the catheter down the longitudinal axis of the catheter, showing the distal opening 116 centrally positioned in relation to the two proximal lumen openings 118 , 120 .
  • the three lumens are designed to have three equal pie-shape lumens along the length of the catheter from the proximal end of the catheter to the proximal openings 118 , 120 .
  • the cross-sectional view of the catheter at the proximal portion of the catheter is represented by FIG. 3B-2 .
  • the two proximal lumens 112 , 114 terminate at 118 and 120 at the distal portion of the catheter, and the distal lumen 116 continues to extend in the distal direction.
  • the distal portion of the catheter expands radially along the length of the catheter from the proximal opening 118 , 120 to the distal tip 124 of the catheter.
  • the inner lumen cross-section along this distal region transition from a pie-shape lumen to a circular lumen.
  • the cross-sectional area of the distal circular opening 124 is larger then the cross-sectional area of the pie-shape opening of the distal lumen at the proximal region of the catheter.
  • the catheter may be designed such that the distal circular opening has the same cross-sectional area as the cross-sectional pie-shape area of the lumen at the proximal portion of the catheter.
  • the two proximal lumens' openings 118 , 120 may be configured with the same cross-sectional area to support fluid flow at the same rate.
  • one of the two proximal lumens is configured with a larger cross-sectional area than the other one of the proximal lumens.
  • FIG. 3C illustrates another example of a dual proximal lumen catheter.
  • the central lumen 116 has a non-circular cross-section.
  • the distal portion 122 of the catheter may be expanded such that the internal cross-sectional area of the central lumen 116 increases along the length of the catheter toward the distal end 124 of the catheter 2 .
  • the catheter's tip portion 122 distal of the two proximal lumens 112 , 114 may expand gradually towards the distal end 124 such that it has a funnel-shaped lumen.
  • the increase in cross-sectional diameter of the central lumen 116 at the distal end 124 may decrease exit velocity of the fluid being infused through the central lumen 116 .
  • side holes may be provided on the circumferential surface of the catheter.
  • side holes/openings may be provided on the distal portion of one or both of the proximal lumens that are used for aspirating blood.
  • FIG. 3D One variation of a catheter having side openings 51 , 53 for a proximal lumen is illustrated in FIG. 3D .
  • the side openings may allow aspiration of blood even if blockage occurs due to suction at the primary opening 55 of the lumen, and may increase flow rates and flow volumes.
  • side holes/openings may also be provided for the distal lumen to facilitate outflow of infused blood/fluids.
  • catheters with side openings 52 , 54 for the distal lumen are shown in FIGS. 1H and 3E .
  • the side openings on the distal lumen may allow enhanced exit flow and provide for alternative flow paths if the end of the catheter is blocked by fibrins/clots.
  • the side holes may be provided at various locations along the length of the catheter, and both the proximal and/or the distal lumens may have side holes added to facilitate aspiration and/or infusion of fluids.
  • the proximal section or the proximal end of the catheters may be molded to fit a connector of specific shape/configuration.
  • three-lumen catheters with various distal tip designs such as the ones shown in FIGS. 1-3 , may be configured such that their proximal ends are provided with three lumens of equal proximal openings 132 , 134 , 136 (as shown in FIG. 3F ) where each of the three proximal openings is configured to provide independent fluid communication to one of the lumens in the distal section and its corresponding distal opening.
  • the lumen distribution pattern at the proximal end of the catheter may reflect the specific catheter tip design at distal end of the catheter and an adaptor may be used to connect each of the lumens to a corresponding fluid source and/or suction source.
  • the catheter may have two large pie-shape/semi-pie-shape lumens and one smaller lumen, and an adaptor with matching connectors may be used to connect the two large lumens to an apheresis or dialysis device while the third lumen is connected to a medication or chemotherapy agent infusion device (e.g., drug pump, syringe, etc.).
  • a medication or chemotherapy agent infusion device e.g., drug pump, syringe, etc.
  • the catheter 2 may be connected to a trifurcation 142 having three separate fluid lines (e.g., tubings) 144 , 146 , 148 for providing independent fluid infusion/aspiration for each of the corresponding lumens 152 , 154 , 156 in the catheter.
  • a triple lumen catheter with a distal lumen 152 and two proximal lumens 154 , 156 may be adapted with a trifurcation 142 for fluid infusion and aspiration, as shown in FIG. 4A .
  • the distal lumen 152 has an opening 182 at the distal tip 158 of the catheter.
  • the proximal lumens each have an opening 184 , 186 located proximal to the distal opening 182 along the length of the catheter, as shown in FIG. 4B .
  • the two proximal lumens'openings 184 , 186 are aligned next to each other along the length of the catheter.
  • the left fluid line 144 is configured to provide independent fluid communication to the proximal lumen on the left 154
  • the right fluid line 148 is configured to provide independent fluid communication to the proximal lumen on the right 156
  • the central fluid line 146 is configured to provide independent fluid communication to the distal lumen 152 , as shown in FIGS. 4A and 4C .
  • tubing clamps 162 , 164 , 166 may be provided to seal off individual fluid lines 144 , 146 , 148 as desired by the operator.
  • the distal portion 172 of the catheter 2 is configured with a tapered profile around the two proximal lumens' distal openings 184 , 186 .
  • L 42 0.2 inches
  • the distal lumen's inner diameter expands along the length of the catheter at this portion 102 (i.e., between the proximal lumen opening and the distal lumen opening).
  • the outer diameter D 41 of the catheter is 0.09 inches, and the inner diameter D 42 of the distal lumen is 0.07 inches.
  • FIG. 4F illustrates the cross-sectional view of the catheter 2 at the proximal portion 174 of the catheter.
  • the outer diameter D 43 of the proximal portion 174 of the catheter is 0.158 inches.
  • the thickness T 41 of the inner lumen dividing walls is 0.015 inches.
  • the outer wall thickness T 42 is 0.015 inches.
  • the proximal portion of the catheter comprises three pie-shaped lumens 154 , 156 , 158 each has a 120 degree inner wall angle A 41 .
  • a triple cavity port 110 may be connected to the proximal end of the catheter 2 to provide the fluid infusion/aspiration interface.
  • the access port comprises three independent fluid cavities 112 , 114 , 116 , each of which is covered with a septum 122 , 124 , 126 .
  • the right cavity 112 is in independent fluid communication with the right lumen 132 of the connection interface 130 .
  • the left cavity 116 is in independent fluid communication with the left lumen 134 of the connection interface 130 .
  • the center cavity 114 is in independent fluid communication with the center lumen 136 of the connection interface.
  • the connection interface may be configured to receive a proximal end of the catheter having three pie-shaped lumens, similar to the one shown in FIG. 3F .
  • a triple lumen catheter 142 having two proximal lumens and a distal lumen may be connected to a triple cavity port 110 , as shown in FIG. 5B .
  • An operator may insert a needle through one of the septums 122 , 124 , 126 to access any one of the cavities 112 , 114 , 116 and selectively inject or aspirate fluids through any one of the proximal and distal lumens in the catheter 142 .
  • Other multi-lumen ports including but not limited to the ones described in U.S. Pat. No.
  • 5,399,168 may also be implemented with the catheters described herein.
  • other fluid input interfaces may also be adapted for use with the various catheter designs disclosed herein to provide a system for infusing and/or aspirating fluids from a patient's circulatory system.
  • the various multi-lumen catheters described above may comprise various elastomeric materials.
  • silicone, poly/silicone blend, Tecothane, Carbothane, Tecoflex, Chronoflex, and other biocompatible elastomeric materials may be utilized to fabricate the catheters described above.
  • Other polymeric materials that are well known to one of ordinary skill in the art that are suitable for use in manufacturing of catheters may also be applied in the present invention. These materials may be made radiopaque through the use of known radiopacifiers such as barium sulfate.
  • the catheter body may comprise of Carbothane 80A-85A with 20% BaSO 4 .
  • the various multi-lumen catheter designs described may be implemented in various medical procedures where independent/separate infusion and/or aspiration of two or more fluids is desired.
  • the staggered three-lumen design may be particularly useful in apheresis, dialysis, or other medical procedures requiring placement of a central line.
  • the catheters described herein may be placed into a patient's body with various surgical procedures well known to one of ordinary skill in the art.
  • One example of implementing a triple lumen catheter having staggered lumens is described below.
  • the physician may determine proper size of catheter to use depending on the physical size and/or weight of the patient.
  • Non-invasive imaging techniques may also be applied to assist the physician in making such determination.
  • a catheter having a central distal lumen and dual proximal lumens is inserted into the right internal jugular vein.
  • the catheter is then advanced into the patient's body along the internal jugular vein. Further advancement will place the distal section of the catheter into the superior vena cava (SVC).
  • SVC superior vena cava
  • Ultrasound, fluoroscope, radiograph, and/or other imaging devices may be utilized to assist the physician in the placement of the catheter.
  • a radiopaque ribbon may be provided at the distal portion of the catheter and/or along the length of the catheter to improve contrast of the catheter within the images captured by the imaging device.
  • the position of the catheter may be adjusted within the SVC and/or right atrium depending on the physician's preference. For example, it may be desirable to position the dual proximal lumen openings next to the SVC/jugular vein junction. Alternatively the openings for the dual proximal lumen may be placed next to the SVC/Right-Atrium junction. In another variation, it may be desirable to place the distal end of the catheter into the right atrium of the heart. Once the catheter is placed in the desired position, the physician may then secure the catheter in place.
  • the proximal end of the catheter may be tunneled underneath the skin so that it exits the skin just beneath the right clavicle and distant from the insertion site.
  • a hemodialysis machine or an apheresis machine may be connected to the catheter to start the treatment process.
  • the proximal end of the catheter may have a trifurcation connector to facilitate the connection process.
  • Blood may then be removed through suction delivered through the catheter to one of the proximal openings of the catheter, and processed blood may be infused back into the patient's circulatory system through a distal opening on the catheter.
  • Chemotherapy agents, antibiotics, anti-nausea medications, blood products, fluids and other medications or nutrients may be infused through a third lumen with a proximal opening on the catheter.

Abstract

Multi-lumen catheters with improved tip configurations, including a triple-lumen catheter which may be useful for apheresis. In one variation, the catheter has three lumens with distal openings angularly spaced apart and staggered axially with respect to one another. In another variation, the catheter has two lumens exiting distally and one centrally positioned lumen exiting proximally. A third variation is a catheter with a single distal opening and two proximal openings. The staggered lumen openings along the axial length of the catheter may decrease recirculation while maximizing flow rates.

Description

PRIORITY
This application is a division of U.S. patent application Ser. No. 10/884,291, filed Jul. 2, 2004, now U.S. Pat. No. 8,323,227, which is incorporated by reference in its entirety into this application.
BACKGROUND OF THE INVENTION
In various medical applications catheters with three or more lumens are needed to deliver and/or withdraw fluid from the patients' circulatory system. For example, the physician may need to divert blood from the circulatory system through a first lumen in the catheter and at the same time reintroduce the removed blood back into the circulatory system through a second lumen. A third lumen in the catheter may be used to introduce medications and/or nutrition supplements. In another example, each of the lumens within a multi-lumen catheter may be used to introduce a different drug into a patient's circulatory system. The use of separate lumens for each drug may prevent premature mixing of the medications.
One common application of a triple lumen catheter is the use of the catheter for apheresis and for delivery of medications during chemotherapy treatment of a cancer patient. Apheresis is a process that involves the removal of whole blood in a dialysis-like fashion. In this process, blood is circulated continuously from the patient to an instrument that acts as a centrifuge or filter, allowing for the separation of specific blood parts. The processed blood is re-circulated back into the patient's body. For example, apheresis may be utilized to separate out stem cells from the blood prior to chemotherapy treatments. This is generally accomplished by hormonally stimulating the production of bone marrow to produce a high number of stem cells. The stem cells are separated from the rest of the blood parts using the triple lumen apheresis catheter. Chemotherapy drugs are then administered using a third lumen in the catheter. After a given length of Chemotherapy treatment time, the stem cells are infused back into the patient's circulatory system.
To allow these blood draws and infusions, a good access to the blood stream in a large vein may be desirable. For example, the triple lumen catheter may be inserted into the patient's subclavian vein that runs behind the clavicle to establish a central line. The proximal end of the catheter may be tunneled under the skin for 2-4 inches to emerge from the chest close to the nipple. The triple lumen catheter may be used for the collection of stem cells and for support of the patient during therapy. In addition to the chemotherapy agent, antibiotics, anti-nausea medications, blood products, and fluids may also be infused through the implanted catheter.
Examples of various multi-lumen catheters are disclosed in U.S. Pat. No. 4,894,057, titled “FLOW ENHANCED MULTI-LUMEN VENOUS CATHETER DEVICE” issued to Howes, dated Jan. 16, 1990; U.S. Pat. No. 5,221,255, titled “REINFORCED MULTIPLE LUMEN CATHETER” issued to Mahurkar et al., dated Jun. 22, 1993; U.S. Pat. No. 5,378,230, titled “TRIPLE-LUMEN CRITICAL CARE CATHETER” issued to Mahurkar, dated Jan. 3, 1995; U.S. Pat. No. 5,395,316, titled “TRIPLE LUMEN CATHETER” issued to Martin, dated Mar. 7, 1995; U.S. U.S. Pat. No. 5,399,168, titled “IMPLANTABLE PLURAL FLUID CAVITY PORT” issued to Wadsworth, Jr. et al., dated Mar. 21, 1995; U.S. Pat. No. 5,451,206, titled “TRIPLE LUMEN CATHETER” issued to Young, dated Sep. 19, 1995; U.S. Pat. No. 5,486,159, titled “MULTIPLE-LUMEN CATHETER” issued to Mahurkar, dated Jan. 23, 1996; each of which is incorporated herein by reference in its entirety.
Due to design constraints, such as dimension/size limitations for insertion into a blood vessel, maintenance of structural integrity during aspiration of blood, etc., a typical multi-lumen catheter tends to possess one or more of the following undesirable properties: high recirculation of blood, low flow rate for blood circulation and medication delivery, high phlebitis, and high tendency for aspirating lumen to suck against the vessel wall. These properties limit the catheter's efficiency in blood circulation and medication delivery, which could minimize the effectiveness of the medical intervention.
Thus, an improved multi-lumen catheter with high blood circulation efficiency and high throughput for medication delivery is desirable. The improved design may incorporate one or more of the following performance characteristics: low recirculation of blood, high flow rates of blood and medications, high flow volume of blood and medications, low phlebitis, delivery of infusates in separate lumens, no dead end openings, limited sucking against vessel wall during aspiration, durable catheter structural design, capable of being produced in high volume, low production cost, capable of being placed over a guide-wire and/or a tunneler, and attractive appearance.
BRIEF SUMMARY OF THE INVENTION
Accordingly, described herein are various multi-lumen catheters each having three or more lumens where at least two of the lumens have distal openings that are staggered along the length of the catheter. The distal openings of the catheters are arranged in various configurations. These modified catheter configurations may improve fluid throughput efficiency and decrease recirculation in the catheter.
In one variation, the catheter comprises a plurality of three or more lumens where the lumen openings at the distal portion of the catheter are staggered along the length of the catheter. Preferably, the lumens are angularly spaced apart and every one of the lumen openings directs the outflow in the axial direction toward the distal end of the catheter. The lumens of the catheter may have a pie-shape cross-section with each lumen becoming narrower toward the axis of the catheter and widening toward the outer circumferential surface of the catheter. In one example, the catheter comprises three staggered lumen openings in intervals of 2.5 cm. Each of two proximal lumens open at approximately a 150 degree angle with respect to one another, while a third lumen opens distally thereof.
In another variation, the catheter comprises two or more lumens exiting at the distal end of the catheter, and at least one lumen exiting proximally along the length of the catheter. In one example, the catheter comprises three lumens, with two of the three lumens exiting distally and the third lumen exiting proximally. Preferably, the third lumen is centrally located relative to the two other lumens. The separation between the single proximal and the dual distal lumens may decrease the possibility of recirculation while maximizing flow rate. The catheter may further comprise a beveled tip for increasing the catheter's ease of insertion while keeping infusates injected through the lumens separate until entering the high blood volume regions of the body.
In yet another variation, the catheter comprises one distal lumen opening, and a plurality of proximal lumen openings. In one variation, the proximal lumens are grouped together along the length of the catheter. The proximal lumen openings may be located at approximately the same axial location along the length of the catheter. In one example, the catheter comprises a single lumen exiting at the distal end of the catheter and two other lumens terminating at the same plane along the length of the catheter proximal to the first lumen opening. In one variation, the two lumens with proximal openings are not offset angularly. In an alternative design, the two lumens may be angularly spaced when viewed from the distal end of the catheter.
These and other embodiments, features and advantages of the present invention will become more apparent to those skilled in the art when taken with reference to the following more detailed description of the invention in conjunction with the accompanying drawings that are first briefly described.
BRIEF DESCRIPTION OF THE DRAWINGS
FIG. 1A shows one variation of a triple lumen catheter with staggered lumen configuration. In this variation, all three lumens are staggered along the length of the catheter with the distance between the distal lumen opening and the mid-lumen opening being marked as L1, and the distance between the mid-lumen opening and the proximal lumen opening being marked as L2.
FIG. 1B shows the cross-sectional view of the catheter from FIG. 1A sectioned at the proximal portion of the catheter. In this variation, the interior of the catheter at the proximal end is divided into three pie-shape lumens.
FIG. 1C illustrates another variation of a triple lumen catheter where the walls of the two proximal lumens extend distally to form flanges around the lumen openings thereof.
FIG. 1D illustrates another design variation with a circular distal lumen and two proximal lumens staggered at intervals along the length of the catheter.
FIG. 1E shows the plain view of the catheter from FIG. 1D, viewed from the distal end of the catheter down the tubing axis. The interior of the catheter at the distal portion comprises a circular lumen and two semi wedge/pie shape lumens.
FIG. 1F illustrates another variation of the staggered lumen design with a primary circular lumen opening and two staggered proximal lumen openings. The two proximal lumens are configured with extended flanges at their distal openings.
FIG. 1G illustrates the cross-sectional view of the catheter from FIG. 1F at the proximal portion of the catheter.
FIG. 1H illustrates yet another variation of the triple lumen staggered design with side openings on the circumferential surface for providing additional fluid exits for the distal lumen.
FIG. 1I illustrates another variation of the staggered lumen design. In this variation, the two proximal lumens are configured with openings on the circumferential surface of the catheter.
FIG. 1J shows the cross-sectional view of the catheter from FIG. 1I at the proximal portion of the catheter.
FIG. 2A illustrates another variation of a triple lumen catheter with the stagger design. In this variation, the catheter comprises two distal lumens which are positioned side-by-side and one proximal lumen. The distal lumens are designed with gradually expanding inner lumens.
FIG. 2B shows the frontal view of the catheter from FIG. 2A, as seen directly down the axis of the catheter with the two distal openings showing.
FIG. 2C shows the cross-sectional view of the catheter from FIG. 2A at the proximal portion of the catheter. As shown, the interior of the catheter at the proximal portion comprises three pie-shape lumens.
FIG. 2D shows another variation of the dual distal lumen design. The distal end of the catheter is configured with a sharper profile as compared to the catheter shown in FIG. 2A.
FIG. 2E illustrates another variation of the dual distal lumen design where the lumens of the catheter extend linearly along the length of the catheter with constant lumen cross-sectional areas along the length of the catheter.
FIG. 2F shows the cross-sectional view of the catheter from FIG. 2E at the proximal portion of the catheter.
FIG. 2G illustrates another variation of the dual distal lumen design where the three lumens have varying shapes and cross-sectional areas.
FIG. 2H illustrates a plain view of the catheter from FIG. 2G, seen from the distal end of the catheter down the axial length of the catheter. As shown, in this variation, each of the three lumens has a semi-pie-shape cross-section.
FIG. 3A illustrates another variation of the stagger lumen design where the catheter comprises two proximal lumens positioned side-by-side and a distal lumen centrally positioned relative to the two proximal lumens.
FIG. 3B-1 shows the plain view of the catheter from FIG. 3A seen from the distal end of the catheter down the longitudinal axis of the catheter.
FIG. 3B-2 shows the cross-sectional view of the catheter from FIG. 3A at the proximal portion of the catheter.
FIG. 3C illustrates another variation of the dual proximal lumen design with a non-circular distal lumen.
FIG. 3D illustrates yet another variation of the dual proximal lumen design with side openings integrated on the circumferential surface of the catheter.
FIG. 3E illustrates another variation of a dual proximal lumen design where side openings are provided for accessing the distal lumen.
FIG. 3F illustrates one variation of a proximal end configuration for a triple lumen catheter.
FIG. 4A illustrates a plain view of one variation of a catheter with a single distal lumen and two proximal lumen configuration where a trifurcation is connected to the proximal end of the catheter.
FIG. 4B illustrates the distal portion of the catheter shown in FIG. 4A.
FIG. 4C illustrates the cross-sectional view of the trifurcation from the catheter system shown in FIG. 4A. The figure illustrates the independent fluid communications provided by the three separate lumens.
FIG. 4D is the side view of the distal portion of the catheter shown in FIG. 4A.
FIG. 4E is the cross-sectional view of the distal portion of the catheter shown in FIG. 4D. The cross-section is taken from the center of the catheter dividing the two proximal lumens.
FIG. 4F is the cross-section view at the proximal portion of the catheter shown in FIG. 4A.
FIG. 5A shows one variation of an access port having three independent cavities each of which has an independent fluid communication path to one of the lumens at the access port connection interface.
FIG. 5B illustrates an example of a triple lumen catheter with staggered lumen openings connected to an access port with three fluid cavities.
DETAILED DESCRIPTION OF THE INVENTION
The following detailed description should be read with reference to the drawings, in which like elements in different drawings are identically numbered. The drawings, which are not necessarily to scale, depict selected preferred embodiments and are not intended to limit the scope of the invention. The detailed description illustrates by way of example, not by way of limitation, the principles of the invention. This description will clearly enable one skilled in the art to make and use the invention, and describes several embodiments, adaptations, variations, alternatives and uses of the invention, including what is presently believed to be the best mode of carrying out the invention.
Before describing the present invention, it is to be understood that unless otherwise indicated this invention need not be limited to applications in humans. As one of ordinary skill in the art would appreciate, variations of the invention may be applied to other mammals as well. Moreover, it should be understood that embodiments of the present invention may be applied in combination with various fluid delivery devices and/or reservoirs for intravascular fluid/medication administration.
A triple lumen catheter is used herein as an example application to illustrate the various aspects of the invention disclosed herein. Variations of the inventions may comprise three or more lumens. It must also be noted that, as used in this specification and the appended claims, the singular forms “a,” “an” and “the” include plural referents unless the context clearly dictates otherwise. Thus, for example, the term “an opening” is intended to mean a single opening or a combination of openings, “a fluid” is intended to mean one or more fluids, or a mixture thereof.
In one aspect of the invention, the catheter comprises three or more lumens with staggered openings at the distal portion of the catheter which exit into the blood stream in intervals of predefined distance(s). Preferably, each of the lumens in the catheter has a separate opening at the distal end so that each of the lumens is in independent fluid communication with the interior of a blood vessel. FIG. 1 illustrates one variation of the catheter 2, with three lumens 4, 6, 8. The openings 12, 14, 16 for the three corresponding lumens 4, 6, 8 are staggered along the length of the catheter 2. The distance between the distal opening 12 and the middle opening 14 is indicated as “L1”, and the distance between the middle opening 14 and the proximal opening 16 is indicated as “L2.” L1 may be larger, smaller, or equal to L2. Preferably, the staggered distance between the openings (e.g., L1, L2) is between about 0.5 cm to about 10 cm, more preferably between about 1 cm to about 5 cm, even more preferably between about 2 cm to about 3 cm, and most preferably about 2.5 cm. For example, openings may be configured such that L1=L2=2.5 cm. In another variation, L1=1 cm, and L2=2.5 cm.
In light of the disclosure herein, one of ordinary skill in the art would appreciate that the catheter may have four, five, six, seven or more lumens, each with a corresponding opening such that the openings are staggered along the length of the catheter in various configurations that are described herein. In some variations the staggered distances between the various openings are the same, in other variations the staggered distances between lumen openings may vary. Furthermore, although in the figures shown herein, each lumen has one opening at the distal portion of the catheter, one of ordinary skill would appreciate that each lumen in the catheter may be configured with additional openings.
In the example shown in FIG. 1A, the lumens 4, 6, 8 have pie-shaped cross-sectional areas. This non-circular lumen cross-sectional design may provide improved flow rate along the length of the catheter for the three lumens. Each of the lumens 4, 6, 8 is bound by two interior walls and a portion of the outer catheter wall, and the two interior walls merge toward the central region of the catheter 2. The three interior walls may meet at the central axis of the catheter, or alternatively, they may meet off the central axis. The first 22 and the second 26 interior walls form an angle “A1”, the second 26 and the third 24 interior walls form an angle “A2”, and the third 24 and first 22 interior walls forms the angle “A3”. In one variation, the two proximal lumens 6, 8 open at 120 degree angles with respect to each other, and the third lumen 4 forms the distal opening (i.e., A1=A2=A3=120 degree), as shown in FIG. 1A. Alternatively, the distal portion of the catheter may be configured such that A1=150 degree, A2=150 degree and A3=60 degree. In light of the disclosure herein, one of ordinary skill in the art would appreciate that the inner walls between the lumens may be configured such that the interface angles A1, A2, A3 may have various combinations. The inner walls' arrangement at the proximal portion 30 of the catheter may be configured to match the corresponding walls at the distal portion of the catheter. For example, at the proximal portion, the three interior walls 22, 24, 26 separating the three lumens may merge at the central region of the catheter 2 to form three wedge-shaped lumens 4, 6, 8, each having an angle of 120 degree (A1=A2=A3=120 degree) as shown in FIG. 1B. Alternatively, at the proximal portion of the catheter, the three interior walls 22, 24, 26 separating the three lumens may have a distinct configuration in relation to the interior walls at the distal portion of the catheter. For example, the lumens at the proximal portion of the catheter may comprise of three cylindrically shaped lumens, and transition into three pie-shaped lumens at the distal portion of the catheter.
In one variation the three lumens 4, 6, 8 have the same cross-sectional area. In another variation, the lumen 4 with the distal opening and the lumen 8 with the proximal opening have the same cross-sectional area while the lumen 6 with the middle opening has a smaller cross-sectional area in comparison to the other two lumens 4, 8. In this variation, the catheter may be implemented for dialysis, where the lumen 8 with the proximal opening may be used to aspirate blood, while the lumen 4 with the distal opening may be used to infuse the processed blood and the third lumen 6 with a smaller opening may be used to infuse medications or nutrients into the patient. In another variation, the lumen 4 with the distal opening may have a larger cross-sectional area in relation to the other two lumens 6, 8, and the two proximal lumens 4, 8 may have the same cross-sectional areas. In yet another variation, the three lumens 4, 6, 8 may have different cross-sectional areas.
The different combination of cross-sectional lumen sizes described above may be implemented in the various catheter designs described herein, and the catheters may have different cross-sectional lumen shapes. For example the lumens may have a circular or square shape instead of the pie-shapes described above. Furthermore, in light of the description herein, one of ordinary skill in the art would appreciate that any two of the three lumens on the catheter may be used for aspirating and infusing blood for dialysis or apheresis purposes, and the third lumen may be used independently for infusing fluids (e.g., saline, medications, nutrients, etc.) or extracting blood from the patient (e.g., taking blood samples). Preferably, the lumen used for aspirating blood has an opening that is proximal from the lumen used for infusing the processed/filtered blood. Also preferably, the lumens used for aspiration and infusion of blood (e.g., for filtering and/or processing) have larger lumens relative to the third lumen in order to maximize the blood processing/filtering rate. However, one of ordinary skill in the art would appreciate that this is not a necessary requirement. For some applications, it may be desirable to use a larger third lumen for delivery of medications or chemotherapy agents.
FIG. 1C illustrates another variation similar to the design shown in FIG. 1A; however, the walls of the proximal lumens 6, 8 have extended flanges 36, 38, 40 around their openings, which may direct blood flow and may provide a smoother surface profile for the catheter to minimize resistance and/or abrasion during insertion of the catheter into an orifice, such as a blood vessel. In addition, theses extended flanges 36, 38, 40 may reduce stress concentration at transitions between profiles.
Referring to FIG. 1D, yet another variation of the staggered lumen design is shown. In this variation, the catheter 2 comprises a primary lumen 4 that has a circular cross-section, while the two proximal lumens 6, 8 have non-circular cross-sections. The semi-pie-shaped lumens 6, 8, allow one to provide two additional lumens around a primary circular lumen without significantly increasing the diameter of the overall catheter. The frontal view of this catheter 2 seen from the distal end down the longitudinal axis of the catheter is shown in FIG. 1E. The proximal portion of the catheter may be configured with three pie-shaped lumens similar to the one shown in FIG. 1B.
Preferably, the two proximal lumens 6, 8 open at approximately 110 to 170 degree angles with respect to each other. More preferably, the two proximal lumens 6, 8 open at approximately 145 to 155 degree angles with respect to each other. And most preferably, the two proximal lumens 6, 8 open at approximately 150 degree angles with respect to each other. The catheter design with two proximal lumens 6, 8 having this pie-shape/semi-pie-shape design may be implemented in a catheter having a circular or semicircular distal lumen 4. In addition, the two proximal lumens 6, 8 having this pie-shape/semi-pie-shape design may be implemented in a catheter having the staggered lumen design described above, or in another design where the two proximal lumens are adjacent to one another along the length of the catheter. Such a design will be described in more detail below. The staggered design may maximize the process efficiency by decreasing recirculation of previously apheresed blood at a preferred flow rate (about 120 ml/min), while allowing the infusion of medications or TPN (Total Parenteral Nutrition) through the third lumen at a preferred flow rate (e.g., equivalent flow of a 5 Fr single lumen PICC). In addition, this design with one distal lumen formed centrally may be optimal for intravenous placement of the catheter via either a guidewire or tunneler, and may be produced in high volumes using radio frequency forming techniques.
FIG. 1F illustrates another design variation with a circular distal lumen opening and two proximal lumens openings 6, 8 which are staggered along the length of the catheter. The two proximal lumens 6, 8 are configured with extending flanges 36, 38, 40 at their lumen openings. As shown in FIG. 1G, in this variation the proximal portion 30 of the catheter 2 comprises three pie-shape lumens.
Preferably, the opening for each of the lumens is positioned at the distal region of the corresponding lumen, and each of the lumen openings has an outflow direction towards the distal region of the catheter along the axis of the catheter. The distal direction is shown as the Z-axis in FIG. 1A. Although lumens with openings exiting toward the distal direction of the catheter are preferred, additional side openings may also be added along the length of the catheter to increase the fluid outflow and/or intake rate. For example, side openings 52, 54 may be added to the distal portion 50 of the catheter 2 to facilitate fluid outflow from the distal lumen 4, as shown in FIG. 1H.
In another variation, the two proximal lumens of the catheter are configured with side openings 62, 64 that open on the circumferential surface of the catheter as the primary inflow/outflow openings, as shown in FIG. 1I. The catheter comprises three lumens. The distal lumen 72 has a circular cross-section at the distal end 68 of the catheter. The two proximal lumens are angularly positioned relative to each other, also shown in FIG. 1I. The proximal openings 62, 64 for the two proximal lumens 74, 76 are staggered along the length of the catheter and are angularly displaced from each other. The circumferential profile along the length of the catheter at the distal portion where the openings of the lumens are located is configured with a slightly tapered profile, such that the overall cross-sectional surface of the catheter decreases along the length of the catheter towards the distal end 68 of the catheter 2. In this variation, the proximal portion of the catheter comprises three pie-shaped lumens. Preferably, the three pie-shaped lumens are of equal sizes, see FIG. 1J.
In another aspect of the invention, the catheter comprises three lumens 82, 84, 86 where two 82, 84 of the three lumens 82, 84, 86 exit distally with a single centrally positioned lumen exiting proximally along the axial length of the catheter, as shown in FIGS. 2A, 2D, 2E, and 2G. The catheter may have a beveled tip to increase the catheter's ease of insertion. The two independent lumens 82, 84 at the distal end 88 allow the user to keep infusates separate until exiting the catheter into the blood stream of the patient. The proximal lumen 86 may be used for aspirating blood out of the patient's circulatory system for apheresis or dialysis applications.
The separation between the single proximal lumen 86 and dual distal lumens 82, 84 (identified as “d” in FIG. 2A) may minimize the recirculation while maximizing the flow rate. In one variation, the catheter is configured for 120 ml/min circulation rate (apheresis/dialysis flow rate) through one distal and one proximal lumen, and an equivalent flow rate of a 5 Fr PICC for the other distal lumen. Furthermore, utilizing radio frequency forming techniques, one may fabricate the catheters described above and achieve lumens with large cross-sectional areas.
Induction heating is observed when conductive materials are subjected to a radio frequency (RF) field. RF energy induces eddy currents in a tipping die made of a conductive material, and heating occurs primarily by I2R heating, that is the power dissipation in a resistive circuit. When the tipping die is also a magnetic material, additional heating effects occur from hysteresis heating, due to the friction created by the magnetic material's resistance to the rapidly changing magnetic field within the induction coil. The tipping die is placed in an induction coil forming a solenoid and the die is heated by the energy transferred from the magnetic field. The specific configuration of the solenoid may depend on the particular design requirement. By varying the current running through the solenoid, the forming temperature changes so that the thermoplastic tubing may be molded into the desired shape. One of ordinary skill in the art would appreciate that RF tipping technique such as the one described above may be implemented in the fabrication of the various catheters described herein. Furthermore, the radio frequency forming techniques may allow efficient production of catheters that are reliable and have low incidence of breakage during use. In addition, the radio frequency tipping process may allow inexpensive reproduction of catheters in large quantities in a high volume production process.
In one variation, the two distal lumens 82, 84 are configured such that the internal lumen cross-sections increase along the length of the catheter as they approach the distal end 88 of the catheter 2. In one example shown in FIG. 2A, once the two distal lumens 82, 84 pass the proximal lumen opening 90, the diameter of the two distal lumens 82, 84 gradually increases along the length of the catheter 2 toward the distal end 88 of the catheter. This expansion in lumen diameter may allow the flow in the lumen of the catheter to have a decreased exit velocity in comparison to the fluid flow velocity along the proximal portion of the catheter where the cross-sectional area of the lumen is smaller. In the example shown in FIG. 2A, the catheter is designed to have an overall diameter that is about the same along the length of the catheter 2. The catheter's overall cross-sectional area (perpendicular to the longitudinal axis of the catheter) at the distal dual openings 92 is slightly smaller than the overall cross-sectional area at the proximal portion 94 of the catheter. FIG. 2B illustrates the frontal view (down the longitudinal axis) of the catheter as seen from the distal end 92 of the catheter 2, and FIG. 2C illustrates the cross-sectional view of the catheter at the proximal portion 94 of the catheter 2. In an alternative design, the distal portion 98 of the catheter may be configured with a larger cross-sectional area than the proximal portion 94 of the catheter. This may further decrease the exit velocity of the fluid coming out of the two distal lumens 82, 84. FIG. 2D illustrates another example of a dual distal lumen design. In this example, the distal end of the catheter 88 is configured with a sharper profile in comparison with the catheter shown in FIG. 2A.
Alternatively, the distal portion 98 of the catheter may be configured with a smaller cross-sectional area than the proximal portion 94 of the catheter. For example, the three lumens 82, 84, 86 of the catheter 2 may have constant cross-sectional areas along the length thereof, as shown in FIG. 2E. The two walls 102, 104 separating the two distal lumens 82, 84 from the proximal lumen 86 continue linearly along the length of the catheter after passing the opening 90 of the proximal lumen 86. FIG. 2F illustrates the cross-sectional view of the catheter from its proximal portion.
Referring to FIG. 2G, another variation is shown where the two distal lumens 82, 84 have different cross-sectional areas. In this example, the right distal lumen 82 is larger than the left distal lumen 84 at the distal portion of the catheter, as shown in FIG. 2H. One may implement this catheter for apheresis applications such that the proximal lumen 86 is used to aspirate blood, the blood is processed and infused back into the circulatory system through the right distal lumen 82, and the left distal lumen 84 is used to infuse medications and/or nutrients. Although medications may be infused through either the right 82 or left 84 distal lumen, it may be preferable to infuse the processed blood through the larger lumen 82 to increase the blood filtering/processing rate.
In yet another aspect of the invention, the catheter 2 is designed with two proximal lumens 112, 114 and one distal lumen 116. Examples of this design are shown in FIGS. 3A, 3C, 3D and 3F. This design may minimize recirculation due to the distance “x” (as shown in FIG. 3A) between the two proximal 112, 114 and one distal 116 lumen while simultaneously maximizing the flow rates and flow volumes. For example, the catheter may be configured for 120 ml/min circulatory flow rate at 250 mmHg through the distal and one proximal lumen, and an equivalent flow rate that is equal or better than 5 Fr PICC for the other proximal lumen. Preferably, the recirculation of the catheter is less than 5% at 120 ml/min. In addition, the single distal lumen 116 may allow easy placement of the catheter 2 using a guidewire or tunneler through the distal lumen 116. Infusate such as medications, chemotherapy agents or nutrients may be delivered independently through one of the proximal lumens while the other proximal lumen may be used for aspiration of blood or for delivery of other fluids. In addition, similar to the other catheters described above, this design may be easily produced in high volume relatively inexpensively utilizing radio frequency techniques.
In one variation, the catheter comprises a central lumen 116 with a circular cross-sectional area at the distal end, and two proximal lumens 112, 114 with their openings 118, 120 positioned side-by-side and proximal to the distal end 124 of the catheter. The distance between the two proximal lumen openings 118, 120 and the distal lumen opening 122 is indicated as “x”. Preferably, x is between about 1 cm to about 10 cm, more preferably about 2 cm to about 5 cm, even more preferably about 2 cm to about 3 cm, and most preferably about 2.5 cm. As shown in FIG. 3A, in this example, the two proximal lumens 112, 114 open at 120 degree angles with respect to each other. Alternatively, the two proximal lumens may be designed to open at other angles (e.g., 150 degrees). The cross-sectional areas of the lumen openings may be pie-shaped. In this example, all three of the lumens 112, 114, 116 direct fluid flow to exit along the axial direction of the catheter toward a distal region beyond the catheter. FIG. 3B-1 illustrates the frontal plain view of the catheter 2 seen from the distal end of the catheter down the longitudinal axis of the catheter, showing the distal opening 116 centrally positioned in relation to the two proximal lumen openings 118, 120. In this particular variation, the three lumens are designed to have three equal pie-shape lumens along the length of the catheter from the proximal end of the catheter to the proximal openings 118, 120. The cross-sectional view of the catheter at the proximal portion of the catheter is represented by FIG. 3B-2. The two proximal lumens 112, 114 terminate at 118 and 120 at the distal portion of the catheter, and the distal lumen 116 continues to extend in the distal direction. As shown in FIG. 3A, in this design the distal portion of the catheter expands radially along the length of the catheter from the proximal opening 118, 120 to the distal tip 124 of the catheter. The inner lumen cross-section along this distal region (i.e., between the proximal openings 118, 120 and the distal opening 124) transition from a pie-shape lumen to a circular lumen. In this design, the cross-sectional area of the distal circular opening 124 is larger then the cross-sectional area of the pie-shape opening of the distal lumen at the proximal region of the catheter. Alternatively, the catheter may be designed such that the distal circular opening has the same cross-sectional area as the cross-sectional pie-shape area of the lumen at the proximal portion of the catheter. Furthermore, the two proximal lumens' openings 118, 120 may be configured with the same cross-sectional area to support fluid flow at the same rate.
In an alternative design, one of the two proximal lumens is configured with a larger cross-sectional area than the other one of the proximal lumens. One may utilize the large proximal lumen in combination with the distal lumen to provide apheresis or dialysis, and utilize the smaller proximal lumen for infusion of medications and/or nutritional supplements.
FIG. 3C illustrates another example of a dual proximal lumen catheter. In this example, the central lumen 116 has a non-circular cross-section. In another variation, the distal portion 122 of the catheter may be expanded such that the internal cross-sectional area of the central lumen 116 increases along the length of the catheter toward the distal end 124 of the catheter 2. For example, the catheter's tip portion 122 distal of the two proximal lumens 112, 114 may expand gradually towards the distal end 124 such that it has a funnel-shaped lumen. The increase in cross-sectional diameter of the central lumen 116 at the distal end 124 may decrease exit velocity of the fluid being infused through the central lumen 116.
The various catheter designs described herein may be further modified to reduce the risk of sucking to the blood vessel walls. This is a common design consideration in all dialysis/continuous flow catheters in order to maximize aspiration rates. In order to decrease the incidence of blockage due to sucking, side holes may be provided on the circumferential surface of the catheter. For example, side holes/openings may be provided on the distal portion of one or both of the proximal lumens that are used for aspirating blood. One variation of a catheter having side openings 51, 53 for a proximal lumen is illustrated in FIG. 3D. The side openings may allow aspiration of blood even if blockage occurs due to suction at the primary opening 55 of the lumen, and may increase flow rates and flow volumes. In another variation, side holes/openings may also be provided for the distal lumen to facilitate outflow of infused blood/fluids. Examples of catheters with side openings 52, 54 for the distal lumen are shown in FIGS. 1H and 3E. The side openings on the distal lumen may allow enhanced exit flow and provide for alternative flow paths if the end of the catheter is blocked by fibrins/clots. As one of ordinary skill in the art would appreciate, the side holes may be provided at various locations along the length of the catheter, and both the proximal and/or the distal lumens may have side holes added to facilitate aspiration and/or infusion of fluids.
In another aspect of the invention, the proximal section or the proximal end of the catheters may be molded to fit a connector of specific shape/configuration. For examples, three-lumen catheters with various distal tip designs, such as the ones shown in FIGS. 1-3, may be configured such that their proximal ends are provided with three lumens of equal proximal openings 132, 134, 136 (as shown in FIG. 3F) where each of the three proximal openings is configured to provide independent fluid communication to one of the lumens in the distal section and its corresponding distal opening. Alternatively, the lumen distribution pattern at the proximal end of the catheter may reflect the specific catheter tip design at distal end of the catheter and an adaptor may be used to connect each of the lumens to a corresponding fluid source and/or suction source. For example, the catheter may have two large pie-shape/semi-pie-shape lumens and one smaller lumen, and an adaptor with matching connectors may be used to connect the two large lumens to an apheresis or dialysis device while the third lumen is connected to a medication or chemotherapy agent infusion device (e.g., drug pump, syringe, etc.).
In one variation, the catheter 2 may be connected to a trifurcation 142 having three separate fluid lines (e.g., tubings) 144, 146, 148 for providing independent fluid infusion/aspiration for each of the corresponding lumens 152, 154, 156 in the catheter. For example, a triple lumen catheter with a distal lumen 152 and two proximal lumens 154, 156 may be adapted with a trifurcation 142 for fluid infusion and aspiration, as shown in FIG. 4A. The distal lumen 152 has an opening 182 at the distal tip 158 of the catheter. The proximal lumens each have an opening 184, 186 located proximal to the distal opening 182 along the length of the catheter, as shown in FIG. 4B. In this particular configuration, the two proximal lumens'openings 184, 186 are aligned next to each other along the length of the catheter. The left fluid line 144 is configured to provide independent fluid communication to the proximal lumen on the left 154, and the right fluid line 148 is configured to provide independent fluid communication to the proximal lumen on the right 156, and the central fluid line 146 is configured to provide independent fluid communication to the distal lumen 152, as shown in FIGS. 4A and 4C. Optionally, tubing clamps 162, 164, 166 may be provided to seal off individual fluid lines 144, 146, 148 as desired by the operator.
Furthermore, in this example the distal portion 172 of the catheter 2 is configured with a tapered profile around the two proximal lumens' distal openings 184, 186. As shown in FIG. 4D, the walls of the proximal lumens 154, 156 have fringes 192, 194, 196 extending along the length of the catheter to provide a smoother transition surface profile at the proximal lumen opening 184, 186 (L42=0.2 inches). From the proximal lumen openings 184, 186 toward the distal lumen opening 182, the catheter's height in the Y direction expands. As shown in FIG. 4E, the distal lumen's inner diameter expands along the length of the catheter at this portion 102 (i.e., between the proximal lumen opening and the distal lumen opening). At the most distal region 104 of the catheter, the outer diameter of the catheter tapers inward toward the axis of the distal lumen 152 (L43=0.1 inches). At the distal tip 158 of the catheter the outer diameter D41 of the catheter is 0.09 inches, and the inner diameter D42 of the distal lumen is 0.07 inches. FIG. 4F illustrates the cross-sectional view of the catheter 2 at the proximal portion 174 of the catheter. The outer diameter D43 of the proximal portion 174 of the catheter is 0.158 inches. The thickness T41 of the inner lumen dividing walls is 0.015 inches. The outer wall thickness T42 is 0.015 inches. The proximal portion of the catheter comprises three pie-shaped lumens 154, 156, 158 each has a 120 degree inner wall angle A41.
In another variation, a triple cavity port 110, such as the one shown in FIG. 5A, may be connected to the proximal end of the catheter 2 to provide the fluid infusion/aspiration interface. In this example, the access port comprises three independent fluid cavities 112, 114, 116, each of which is covered with a septum 122, 124, 126. The right cavity 112 is in independent fluid communication with the right lumen 132 of the connection interface 130. The left cavity 116 is in independent fluid communication with the left lumen 134 of the connection interface 130. The center cavity 114 is in independent fluid communication with the center lumen 136 of the connection interface. The connection interface may be configured to receive a proximal end of the catheter having three pie-shaped lumens, similar to the one shown in FIG. 3F. For example, a triple lumen catheter 142 having two proximal lumens and a distal lumen may be connected to a triple cavity port 110, as shown in FIG. 5B. An operator may insert a needle through one of the septums 122, 124, 126 to access any one of the cavities 112, 114, 116 and selectively inject or aspirate fluids through any one of the proximal and distal lumens in the catheter 142. Other multi-lumen ports, including but not limited to the ones described in U.S. Pat. No. 5,399,168, may also be implemented with the catheters described herein. In light of the disclosure herein, one of ordinary skill in the art would appreciate that other fluid input interfaces may also be adapted for use with the various catheter designs disclosed herein to provide a system for infusing and/or aspirating fluids from a patient's circulatory system.
The various multi-lumen catheters described above may comprise various elastomeric materials. For example, silicone, poly/silicone blend, Tecothane, Carbothane, Tecoflex, Chronoflex, and other biocompatible elastomeric materials may be utilized to fabricate the catheters described above. Other polymeric materials that are well known to one of ordinary skill in the art that are suitable for use in manufacturing of catheters may also be applied in the present invention. These materials may be made radiopaque through the use of known radiopacifiers such as barium sulfate. For example, the catheter body may comprise of Carbothane 80A-85A with 20% BaSO4.
In light of the disclosure herein one of ordinary skill in the art would appreciate that the various multi-lumen catheter designs described may be implemented in various medical procedures where independent/separate infusion and/or aspiration of two or more fluids is desired. For example, the staggered three-lumen design may be particularly useful in apheresis, dialysis, or other medical procedures requiring placement of a central line. Moreover, the catheters described herein may be placed into a patient's body with various surgical procedures well known to one of ordinary skill in the art. One example of implementing a triple lumen catheter having staggered lumens is described below.
Before implantation of the triple lumen catheter, the physician may determine proper size of catheter to use depending on the physical size and/or weight of the patient. Non-invasive imaging techniques may also be applied to assist the physician in making such determination. In one approach, a catheter having a central distal lumen and dual proximal lumens is inserted into the right internal jugular vein. The catheter is then advanced into the patient's body along the internal jugular vein. Further advancement will place the distal section of the catheter into the superior vena cava (SVC). Ultrasound, fluoroscope, radiograph, and/or other imaging devices may be utilized to assist the physician in the placement of the catheter. A radiopaque ribbon may be provided at the distal portion of the catheter and/or along the length of the catheter to improve contrast of the catheter within the images captured by the imaging device. The position of the catheter may be adjusted within the SVC and/or right atrium depending on the physician's preference. For example, it may be desirable to position the dual proximal lumen openings next to the SVC/jugular vein junction. Alternatively the openings for the dual proximal lumen may be placed next to the SVC/Right-Atrium junction. In another variation, it may be desirable to place the distal end of the catheter into the right atrium of the heart. Once the catheter is placed in the desired position, the physician may then secure the catheter in place. Optionally, the proximal end of the catheter may be tunneled underneath the skin so that it exits the skin just beneath the right clavicle and distant from the insertion site. Once the catheter has been placed, a hemodialysis machine or an apheresis machine may be connected to the catheter to start the treatment process. For example, the proximal end of the catheter may have a trifurcation connector to facilitate the connection process. Blood may then be removed through suction delivered through the catheter to one of the proximal openings of the catheter, and processed blood may be infused back into the patient's circulatory system through a distal opening on the catheter. Chemotherapy agents, antibiotics, anti-nausea medications, blood products, fluids and other medications or nutrients may be infused through a third lumen with a proximal opening on the catheter.
This invention has been described and specific examples of the invention have been portrayed. While the invention has been described in terms of particular variations and illustrative figures, those of ordinary skill in the art will recognize that the invention is not limited to the variations or figures described. In addition, where methods and steps described above indicate certain events occurring in certain order, those of ordinary skill in the art will recognize that the ordering of certain steps may be modified and that such modifications are in accordance with the variations of the invention. Additionally, certain of the steps may be performed concurrently in a parallel process when possible, as well as performed sequentially as described above. Therefore, to the extent there are variations of the invention, which are within the spirit of the disclosure or equivalent to the inventions found in the claims, it is the intent that this patent will cover those variations as well. Finally, all publications and patent applications cited in this specification are herein incorporated by reference in their entirety as if each individual publication or patent application were specifically and individually put forth herein.

Claims (10)

What is claimed is:
1. A multi-lumen catheter, comprising:
a first interior wall separating a first lumen from a second lumen;
a second interior wall separating the first lumen from a third lumen;
a third interior wall separating the second lumen from the third lumen;
a first distal opening in fluid communication with the first lumen;
a second distal opening in fluid communication with the second lumen; and
a third distal opening in fluid communication with the third lumen, the third distal opening positioned axially side-by-side the second distal opening at a distal end of the catheter, the first distal opening positioned proximal of the second and third distal openings.
2. The multi-lumen catheter according to claim 1, wherein the second interior wall and the first interior wall form an angle of approximately 120 degrees.
3. The multi-lumen catheter according to claim 1, wherein a first overall cross-sectional area of the catheter proximal of the first distal opening is greater than a second overall cross-sectional area distal of the first distal opening.
4. The multi-lumen catheter according to claim 1, wherein the second and third lumens increase in cross-sectional area from the first distal opening to the distal end of the catheter.
5. The multi-lumen catheter according to claim 4, wherein a first overall cross-sectional area of the catheter proximal of the first distal opening is less than a second overall cross-sectional area distal of the first distal opening.
6. The multi-lumen catheter according to claim 1, wherein the third interior wall defines a distal-most end of the catheter, and wherein a distal end of the third interior wall forms an oblique angle with respect to a longitudinal axis of the catheter.
7. The multi-lumen catheter according to claim 6, wherein the first and second interior walls extend distal of the first opening to form an outer wall section of the catheter.
8. The multi-lumen catheter according to claim 1, wherein each of the first, second, and third lumens has a constant cross-section from a proximal end of the catheter to the distal end thereof.
9. The multi-lumen catheter according to claim 8, wherein each of the first, second, and third lumens has a similar cross-sectional shape.
10. The multi-lumen catheter according to claim 8, wherein the second lumen has a cross-sectional area greater than a cross-sectional area of the third lumen.
US13/687,919 2004-07-02 2012-11-28 Tip configurations for multi-lumen catheter Active US8894607B2 (en)

Priority Applications (3)

Application Number Priority Date Filing Date Title
US13/687,919 US8894607B2 (en) 2004-07-02 2012-11-28 Tip configurations for multi-lumen catheter
US14/104,739 US9656041B2 (en) 2004-07-02 2013-12-12 Tip configurations for multi-lumen catheter
US14/543,499 US9839763B2 (en) 2004-07-02 2014-11-17 Tip configurations for multi-lumen catheter

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US10/884,291 US8323227B2 (en) 2004-07-02 2004-07-02 Tip configurations for a multi-lumen catheter
US13/687,919 US8894607B2 (en) 2004-07-02 2012-11-28 Tip configurations for multi-lumen catheter

Related Parent Applications (1)

Application Number Title Priority Date Filing Date
US10/884,291 Division US8323227B2 (en) 2004-07-02 2004-07-02 Tip configurations for a multi-lumen catheter

Related Child Applications (2)

Application Number Title Priority Date Filing Date
US14/104,739 Division US9656041B2 (en) 2004-07-02 2013-12-12 Tip configurations for multi-lumen catheter
US14/543,499 Division US9839763B2 (en) 2004-07-02 2014-11-17 Tip configurations for multi-lumen catheter

Publications (2)

Publication Number Publication Date
US20130085436A1 US20130085436A1 (en) 2013-04-04
US8894607B2 true US8894607B2 (en) 2014-11-25

Family

ID=35514970

Family Applications (4)

Application Number Title Priority Date Filing Date
US10/884,291 Active 2031-07-08 US8323227B2 (en) 2004-07-02 2004-07-02 Tip configurations for a multi-lumen catheter
US13/687,919 Active US8894607B2 (en) 2004-07-02 2012-11-28 Tip configurations for multi-lumen catheter
US14/104,739 Active 2025-12-14 US9656041B2 (en) 2004-07-02 2013-12-12 Tip configurations for multi-lumen catheter
US14/543,499 Active 2025-02-24 US9839763B2 (en) 2004-07-02 2014-11-17 Tip configurations for multi-lumen catheter

Family Applications Before (1)

Application Number Title Priority Date Filing Date
US10/884,291 Active 2031-07-08 US8323227B2 (en) 2004-07-02 2004-07-02 Tip configurations for a multi-lumen catheter

Family Applications After (2)

Application Number Title Priority Date Filing Date
US14/104,739 Active 2025-12-14 US9656041B2 (en) 2004-07-02 2013-12-12 Tip configurations for multi-lumen catheter
US14/543,499 Active 2025-02-24 US9839763B2 (en) 2004-07-02 2014-11-17 Tip configurations for multi-lumen catheter

Country Status (3)

Country Link
US (4) US8323227B2 (en)
JP (1) JP2008504897A (en)
WO (1) WO2006014339A2 (en)

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20140107591A1 (en) * 2004-07-02 2014-04-17 C. R. Bard, Inc. Tip Configurations for Multi-Lumen Catheter
US10004842B2 (en) 2011-08-11 2018-06-26 Medical Components, Inc. Method and apparatus for the dialysis of blood
USD905853S1 (en) 2018-02-27 2020-12-22 Medical Components, Inc. Catheter tip
USD984880S1 (en) 2020-11-06 2023-05-02 Medical Components, Inc. Clamp with indicator

Families Citing this family (109)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2626830A1 (en) 1998-02-24 1999-08-26 Boston Scientific Limited High flow rate dialysis catheters and related methods
US7077829B2 (en) * 2001-01-09 2006-07-18 Rex Medical, L.P. Dialysis catheter
US6814718B2 (en) * 2001-01-09 2004-11-09 Rex Medical, L.P Dialysis catheter
US8323228B2 (en) * 2007-04-12 2012-12-04 Rex Medical L.P. Dialysis catheter
US6758836B2 (en) 2002-02-07 2004-07-06 C. R. Bard, Inc. Split tip dialysis catheter
US7393339B2 (en) 2003-02-21 2008-07-01 C. R. Bard, Inc. Multi-lumen catheter with separate distal tips
US7267620B2 (en) * 2003-05-21 2007-09-11 Taylor Made Golf Company, Inc. Golf club head
US20040243095A1 (en) 2003-05-27 2004-12-02 Shekhar Nimkar Methods and apparatus for inserting multi-lumen spit-tip catheters into a blood vessel
US8992454B2 (en) 2004-06-09 2015-03-31 Bard Access Systems, Inc. Splitable tip catheter with bioresorbable adhesive
EP1806158A1 (en) * 2004-09-27 2007-07-11 Koken Co., Ltd. Tracheal cannula
US20070123935A1 (en) * 2005-11-30 2007-05-31 Myers Gene E Method and apparatus for contemporaneous formation of a body structure opening and homologous pedicle
US20070202186A1 (en) 2006-02-22 2007-08-30 Iscience Interventional Corporation Apparatus and formulations for suprachoroidal drug delivery
US8029457B2 (en) 2006-03-24 2011-10-04 Aat Catheter Technologies, Llc Indwelling catheter with anti-clotting features
WO2007120505A1 (en) 2006-03-31 2007-10-25 C. R. Bard, Inc. Catheter including arcuate transition region
US8197435B2 (en) 2006-05-02 2012-06-12 Emory University Methods and devices for drug delivery to ocular tissue using microneedle
JP4945174B2 (en) * 2006-06-23 2012-06-06 ユニチカ株式会社 4 lumen catheter
US20080082079A1 (en) * 2006-09-28 2008-04-03 Tyco Healthcare Group Lp Low profile catheter assembly
US9168355B2 (en) * 2006-09-29 2015-10-27 Covidien Lp Acute hemodialysis catheter assembly
US20080154186A1 (en) * 2006-11-07 2008-06-26 Angiodynamics, Inc. Multiple lumen catheter with proximal port
US8317773B2 (en) * 2006-11-07 2012-11-27 Angio Dynamics, Inc. Catheter with open faced sloped end portion
US8002729B2 (en) 2007-08-21 2011-08-23 Cook Medical Technologies Llc Multi-lumen catheter assembly
CN101918066B (en) 2007-10-17 2013-07-31 巴德阿克塞斯系统股份有限公司 Manufacture of split tip catheters and the split tip catheters
WO2009052506A1 (en) * 2007-10-19 2009-04-23 Navilyst Medical, Inc. Recirculation minimizing catheter
US8292841B2 (en) 2007-10-26 2012-10-23 C. R. Bard, Inc. Solid-body catheter including lateral distal openings
US8066660B2 (en) 2007-10-26 2011-11-29 C. R. Bard, Inc. Split-tip catheter including lateral distal openings
US9579485B2 (en) 2007-11-01 2017-02-28 C. R. Bard, Inc. Catheter assembly including a multi-lumen configuration
CN101918067B (en) * 2007-11-01 2013-04-10 C·R·巴德股份有限公司 Catheter assembly including triple lumen tips
US20090118673A1 (en) * 2007-11-07 2009-05-07 Jerett Creed Needle injection catheter
US7719869B2 (en) * 2007-11-19 2010-05-18 Qimonda Ag Memory cell array comprising floating body memory cells
US20090205189A1 (en) * 2008-02-15 2009-08-20 Spire Corporation Manufacture of fixed tip catheters
US9504816B2 (en) 2008-03-17 2016-11-29 Syringetech Llc Multi-mode syringe
US9399112B2 (en) 2008-04-22 2016-07-26 Becton, Dickinson And Company Catheter hole having an inclined trailing edge
US9364634B2 (en) 2008-04-22 2016-06-14 Becton, Dickinson And Company Systems and methods for improving catheter hole array efficiency
US8496629B2 (en) 2008-04-22 2013-07-30 Becton, Dickinson And Company Catheter hole having a flow breaking feature
JP2009273609A (en) 2008-05-14 2009-11-26 Nippon Sherwood Medical Industries Ltd Catheter with valve
US20090312617A1 (en) * 2008-06-12 2009-12-17 Jerett Creed Needle injection catheter
CA2729029A1 (en) * 2008-07-16 2010-01-21 Heartware Inc. Cannula tip for use with a vad
US9005154B2 (en) * 2008-09-26 2015-04-14 Covidien Lp Valved hemodialysis catheter
US20100145285A1 (en) * 2008-12-09 2010-06-10 Cook Critical Care, Incorporated Multi-lumen catheter configuration
US20100256546A1 (en) * 2009-04-03 2010-10-07 Davis Scott A Polycarbonate Polyurethane Venous Access Devices Having Enhanced Strength
GB2471517B (en) 2009-07-02 2011-09-21 Cook William Europ Implant deployment catheter
JP2011050420A (en) 2009-08-31 2011-03-17 Nippon Sherwood Medical Industries Ltd Valved catheter
US20110071500A1 (en) * 2009-09-21 2011-03-24 Navilyst Medical, Inc. Branched catheter tip
CA2715857A1 (en) 2009-09-30 2011-03-30 Tyco Healthcare Group Lp Medical catheter having a design providing low recirculation and reversibility
US8377034B2 (en) * 2009-12-04 2013-02-19 Std Med, Inc. Vascular access port
US8496607B2 (en) * 2009-12-04 2013-07-30 Cook Medical Technologies Llc Multi-lumen catheter
US10603466B2 (en) 2009-12-14 2020-03-31 Michael G. Tal Intravascular catheter with positioning markers and method of placement
US8328760B2 (en) * 2010-01-11 2012-12-11 Angiodynamics, Inc. Occlusion resistant catheter
US8628513B2 (en) * 2010-04-07 2014-01-14 Medtronic Vascular, Inc. Cell reservoirs created by polymer plugs
US9205224B2 (en) * 2010-04-08 2015-12-08 Cook Medical Technologies, LLC Infusion mechanism and method
US20120065567A1 (en) * 2010-06-02 2012-03-15 Zarate Alfredo R Hemodialysis system and method
US8591450B2 (en) 2010-06-07 2013-11-26 Rex Medical L.P. Dialysis catheter
EP3520749A1 (en) 2010-10-15 2019-08-07 Clearside Biomedical, Inc. Device for ocular access
JP5713732B2 (en) 2011-03-08 2015-05-07 日本コヴィディエン株式会社 Catheter with valve
US9999746B2 (en) 2011-03-22 2018-06-19 Angiodynamics, Inc. High flow catheters
US9050435B2 (en) 2011-03-22 2015-06-09 Angiodynamics, Inc. High flow catheters
US9402975B2 (en) * 2011-08-31 2016-08-02 Becton, Dickinson And Company Systems and methods to increase rigidity and snag-resistance of catheter tip
US9554822B2 (en) * 2011-09-02 2017-01-31 Abbott Cardiovascular Systems Inc. Thrombectomy catheter with aspiration and guidewire lumens defining an asymmetrical taper and cutting edge with offset tip
US8747343B2 (en) 2011-09-30 2014-06-10 Covidien Lp Hemodialysis catheter with improved side opening design
US9072867B2 (en) 2011-09-30 2015-07-07 Covidien Lp Catheter with external flow channel
WO2013101912A1 (en) * 2011-12-29 2013-07-04 Cook Medical Technoloies Llc Space-optimized visualization catheter with camera train holder
US9668643B2 (en) 2011-12-29 2017-06-06 Cook Medical Technologies Llc Space-optimized visualization catheter with oblong shape
USD736916S1 (en) * 2012-01-09 2015-08-18 Angiodynamics, Inc. Dialysis catheter tip
US9707339B2 (en) 2012-03-28 2017-07-18 Angiodynamics, Inc. High flow rate dual reservoir port system
US9713704B2 (en) 2012-03-29 2017-07-25 Bradley D. Chartrand Port reservoir cleaning system and method
US10143822B2 (en) 2012-07-05 2018-12-04 Covidien Lp Valved tip catheters
US20140018772A1 (en) * 2012-07-16 2014-01-16 Merit Medical Systems, Inc. Self-centering catheter with anti-occlusion features
US9155862B2 (en) 2012-09-28 2015-10-13 Covidien Lp Symmetrical tip acute catheter
CN110893188A (en) 2012-11-08 2020-03-20 克莱尔塞德生物医学股份有限公司 Methods and devices for treating ocular diseases in human subjects
US10252023B2 (en) 2013-01-11 2019-04-09 C. R. Bard, Inc. Curved catheter and methods for making same
USD748252S1 (en) 2013-02-08 2016-01-26 C. R. Bard, Inc. Multi-lumen catheter tip
US20140276026A1 (en) * 2013-03-13 2014-09-18 Volcano Corporation Devices and methods for imaging and delivering a fertilized egg into a woman's uterus
US10064575B2 (en) * 2013-04-17 2018-09-04 Fluisense Aps Multi lumen catheter
CN116327482A (en) 2013-05-03 2023-06-27 科尼尔赛德生物医学公司 Apparatus and method for ocular injection
EP3003454B1 (en) 2013-06-03 2020-01-08 Clearside Biomedical, Inc. Apparatus for drug delivery using multiple reservoirs
US10039899B2 (en) * 2013-09-27 2018-08-07 Covidien Lp Multiple lumen catheters
JP6261612B2 (en) 2013-12-20 2018-01-17 オリンパス株式会社 Guide member for soft manipulator and soft manipulator
US10166321B2 (en) 2014-01-09 2019-01-01 Angiodynamics, Inc. High-flow port and infusion needle systems
US10369345B2 (en) 2014-03-31 2019-08-06 Versago Vascular Access, Inc. Medical access port, systems and methods of use thereof
US9764124B2 (en) 2014-03-31 2017-09-19 Versago Vascular Access, Inc. Vascular access port
US10512734B2 (en) 2014-04-03 2019-12-24 Versago Vascular Access, Inc. Devices and methods for installation and removal of a needle tip of a needle
US10357647B2 (en) 2014-06-02 2019-07-23 Medtronic, Inc. Tunneling tool
MX2016017028A (en) 2014-06-20 2017-08-07 Clearside Biomedical Inc Variable diameter cannula and methods for controlling insertion depth for medicament delivery.
CN106604681B (en) * 2014-07-02 2018-06-01 赛特萨弗股份有限公司以利尼厄斯医药的名义经营 Vein access device
WO2016011091A1 (en) 2014-07-14 2016-01-21 C. R. Bard, Inc. Apparatuses, systems, and methods for inserting split tip catheters having enhanced stiffening and guiding features
EP3200859B1 (en) * 2014-10-02 2019-11-20 CardiacAssist, Inc. Va ecmo with pulmonary artery ventilation
USD750223S1 (en) 2014-10-14 2016-02-23 Clearside Biomedical, Inc. Medical injector for ocular injection
JP6673919B2 (en) 2014-12-18 2020-03-25 ヴェルサゴ ヴァスキュラー アクセス インコーポレイテッド Devices, systems, and methods for removal and replacement of catheters for implantable access ports
CA2971215A1 (en) 2014-12-18 2016-06-23 Versago Vascular Access, Inc. Catheter patency systems and methods
CA2992455A1 (en) 2015-07-14 2017-01-19 Versago Vascular Access, Inc. Medical access ports, transfer devices and methods of use thereof
US9572555B1 (en) * 2015-09-24 2017-02-21 Ethicon, Inc. Spray or drip tips having multiple outlet channels
EP3413851B1 (en) 2016-02-10 2023-09-27 Clearside Biomedical, Inc. Packaging
CA3062845A1 (en) 2016-05-02 2017-11-09 Clearside Biomedical, Inc. Systems and methods for ocular drug delivery
CN109152911B (en) * 2016-08-04 2021-04-27 株式会社钟化 Suction catheter and method for manufacturing suction catheter
IL264764B2 (en) 2016-08-12 2024-02-01 Clearside Biomedical Inc Devices and methods for adjusting the insertion depth of a needle for medicament delivery
US10357601B1 (en) 2016-09-06 2019-07-23 Chrysalis Medical, Inc. Method and apparatus for fibrin sheath disruption
US10610668B2 (en) 2016-10-05 2020-04-07 Becton, Dickinson And Company Catheter with an asymmetric tip
WO2018187577A2 (en) * 2017-04-06 2018-10-11 Smiths Medical Asd, Inc. Recoil balancing catheter
JP7106970B2 (en) 2017-05-26 2022-07-27 ニプロ株式会社 triple lumen catheter
WO2019099583A1 (en) * 2017-11-15 2019-05-23 Alcyone Lifesciences, Inc. Therapy specific, pre-programmed auto injection device
US11058815B2 (en) 2017-12-21 2021-07-13 Versago Vascular Access, Inc. Medical access ports, transfer devices and methods of use thereof
US20200085453A1 (en) * 2018-09-17 2020-03-19 Stryker Corporation Intra-ventricular infusion and evacuation catheter for treatment of intracerebral hemorrhage (ich)
US11298506B2 (en) * 2018-09-17 2022-04-12 Stryker Corporation Intra-ventricular infusion and evacuation catheter for treatment of intracerebral hemorrhage (ICH)
KR102341692B1 (en) * 2019-05-21 2021-12-21 성균관대학교산학협력단 Catheter
US11684749B2 (en) 2019-09-04 2023-06-27 Medical Components, Inc. Catheter with tapered self-introducing low-recirculation distal tip
US20240024623A1 (en) * 2020-02-04 2024-01-25 Franz E. Velarde Cuffed and non-cuffed dialysis catheter systems and methods
US20230073895A1 (en) * 2020-03-24 2023-03-09 Walzman Innovations. Llc Vessel access catheter
EP4233960A1 (en) * 2020-12-01 2023-08-30 Nipro Corporation Multilumen catheter
WO2023278495A2 (en) 2021-06-28 2023-01-05 Inquis Medical, Inc. Apparatuses and methods for controlling removal of obstructive material

Citations (138)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US1696018A (en) 1926-07-10 1928-12-18 Schellberg Oscar Boto Colonic theraphy apparatus
US2393002A (en) 1944-05-03 1946-01-15 Smith Minton Larkin Kidney catheter
US3256885A (en) 1963-06-26 1966-06-21 Roehr Products Company Inc Aspirating device
US3416532A (en) 1964-07-24 1968-12-17 Grossman Alan Richard Drainage tube with means for scraping away debris therewithin
US3426759A (en) 1966-04-04 1969-02-11 Davol Inc Abdominal suction drainage tube
US3812851A (en) 1972-11-21 1974-05-28 P Rodriguez I. v. arm rest and support
US3929126A (en) 1974-09-26 1975-12-30 Jay C Corsaut Surgical suction irrigator
US3995623A (en) 1974-12-23 1976-12-07 American Hospital Supply Corporation Multipurpose flow-directed catheter
US4072146A (en) 1976-09-08 1978-02-07 Howes Randolph M Venous catheter device
US4129129A (en) 1977-03-18 1978-12-12 Sarns, Inc. Venous return catheter and a method of using the same
US4149535A (en) 1976-05-06 1979-04-17 Gist-Brocades N.V. Catheter holding device
US4180068A (en) 1978-04-13 1979-12-25 Motion Control, Incorporated Bi-directional flow catheter with retractable trocar/valve structure
US4385631A (en) 1980-03-21 1983-05-31 Ulrich Uthmann Catheter
US4406656A (en) 1981-06-01 1983-09-27 Brack Gillium Hattler Venous catheter having collapsible multi-lumens
US4451252A (en) 1981-07-24 1984-05-29 Vas-Cath Of Canada Limited Cannula
US4468216A (en) 1982-05-20 1984-08-28 Rudolph Muto Irrigation suction catheter
US4493696A (en) 1979-12-28 1985-01-15 Allentyne Limited Hemodialysis cannular for subclavian insertion
US4557261A (en) 1980-12-20 1985-12-10 Ruegheimer Erich Connection system for fluid lines having telescoping connecting elements, in particular for respirators or anesthetic units
US4563180A (en) 1984-06-29 1986-01-07 Raychem Corporation High flow catheter for injecting fluids
US4583986A (en) 1981-07-20 1986-04-22 Combe Incorporated Catalyzed bismuth dye system for human hair
US4626240A (en) 1981-11-06 1986-12-02 Shiley Incorporated Dual lumen subclavian cannula
US4643711A (en) 1984-05-25 1987-02-17 Cook, Inc. Two lumen hemodialysis catheter
US4666426A (en) 1984-01-12 1987-05-19 Karl Aigner Double lumen catheter for a device for in-vivo purification of blood
US4668221A (en) 1985-03-28 1987-05-26 Luther Medical Products, Inc. Assembly of stylet and catheter
US4681564A (en) 1985-10-21 1987-07-21 Landreneau Michael D Catheter assembly having balloon extended flow path
US4681570A (en) 1985-12-26 1987-07-21 Dalton Michael J Peritoneal catheter
US4682978A (en) 1984-05-24 1987-07-28 Vas-Cath Of Canada Limited Dual lumen cannula
US4687471A (en) 1985-05-01 1987-08-18 Curators Of The University Of Missouri Peritoneal dialysis catheter
US4755176A (en) 1987-06-11 1988-07-05 Patel Piyush V Catheter with side hole
US4772269A (en) 1985-05-01 1988-09-20 Curators Of The University Of Missouri Peritoneal dialysis catheter
US4808155A (en) 1986-02-27 1989-02-28 Mahurkar Sakharam D Simple double lumen catheter
US4842582A (en) 1985-02-12 1989-06-27 Mahurkar Sakharam D Method and apparatus for using dual-lumen catheters for extracorporeal treatment
US4863441A (en) 1987-07-17 1989-09-05 Minnesota Mining And Manufacturing Company Venous return catheter
US4867742A (en) 1986-06-06 1989-09-19 Reynaldo Calderon Retrograde perfusion
US4894057A (en) 1987-06-19 1990-01-16 Howes Randolph M Flow enhanced multi-lumen venous catheter device
US4895561A (en) 1988-05-16 1990-01-23 Mahurkar Sakharam D Dual-lumen catheter-connecting system
US4935044A (en) 1988-03-01 1990-06-19 Linde Aktiengesellschaft Purification of crude argon
US4961809A (en) 1988-04-21 1990-10-09 Vas-Cath Incorporated Method of producing a dual lumen catheter including forming a flare
US4981477A (en) 1988-04-16 1991-01-01 Rudolf Schon Catheter for introduction into the trachea and the bronchial system
US4985014A (en) 1989-07-11 1991-01-15 Orejola Wilmo C Ventricular venting loop
US4995865A (en) 1989-06-09 1991-02-26 Worldwide Medical Plastics Inc. Multi-lumen catheters
US5015230A (en) 1989-01-30 1991-05-14 Vas-Cath Incorporated Angioplasty catheter with spiral balloon
WO1991006845A2 (en) 1989-10-27 1991-05-16 American Tech Manufacturing, Corp. Coplanarity inspection machine
US5041107A (en) 1989-10-06 1991-08-20 Cardiac Pacemakers, Inc. Electrically controllable, non-occluding, body implantable drug delivery system
US5053023A (en) 1988-10-25 1991-10-01 Vas-Cath Incorporated Catheter for prolonged access
US5053004A (en) 1990-08-24 1991-10-01 Medical Components, Inc. Catheter having two coaxial lumens
US5057073A (en) 1988-04-21 1991-10-15 Vas-Cath Incorporated Dual lumen catheter
US5106376A (en) 1989-07-07 1992-04-21 B. Braun Melsungen Ag Anaesthesia set
EP0495263A1 (en) 1990-12-27 1992-07-22 The Kendall Company Multilumen catheter
US5135599A (en) 1987-12-22 1992-08-04 Vas-Cath Incorporated Method of making a triple lumen catheter
US5156592A (en) 1990-04-04 1992-10-20 Martin Geoffrey S Pre-curved dual lumen catheter
US5171216A (en) 1989-08-28 1992-12-15 Thermedics, Inc. Multi-lumen catheter coupling
US5171227A (en) 1991-04-16 1992-12-15 The Curators Of The University Of Missouri Separable peritoneal dialysis catheter
US5188593A (en) 1988-04-21 1993-02-23 Vas-Cath Incorporated Dual lumen catheter
US5190520A (en) 1990-10-10 1993-03-02 Strato Medical Corporation Reinforced multiple lumen catheter
US5195962A (en) 1987-12-22 1993-03-23 Vas-Cath Incorporated Triple lumen catheter
US5209723A (en) 1990-01-08 1993-05-11 The Curators Of The University Of Missouri Multiple lumen catheter for hemodialysis
US5215527A (en) 1991-12-12 1993-06-01 Becton, Dickinson And Company Catheter introducer assembly
US5221255A (en) 1990-01-10 1993-06-22 Mahurkar Sakharam D Reinforced multiple lumen catheter
US5221256A (en) 1992-02-10 1993-06-22 Mahurkar Sakharam D Multiple-lumen catheter
US5226880A (en) 1989-01-31 1993-07-13 Vas-Cath Incorporated Angioplasty catheter with balloon retainer
US5242398A (en) 1992-03-12 1993-09-07 Knoll Charles L Catheter assembly and related method
US5324274A (en) 1992-03-30 1994-06-28 Med-Pro Design, Inc. Catheter having rotary valves
US5342295A (en) 1993-09-24 1994-08-30 Cardiac Pathways Corporation Catheter assembly, catheter and multi-port introducer for use therewith
US5346471A (en) 1993-03-22 1994-09-13 Raulerson J Daniel Dual lumen catheter
US5348536A (en) 1993-08-02 1994-09-20 Quinton Instrument Company Coextruded catheter and method of forming
US5350358A (en) 1992-12-22 1994-09-27 Med-Pro Design, Inc. Bent co-axial catheter
US5374245A (en) 1990-01-10 1994-12-20 Mahurkar; Sakharam D. Reinforced multiple-lumen catheter and apparatus and method for making the same
US5378230A (en) 1993-11-01 1995-01-03 Mahurkar; Sakharam D. Triple-lumen critical care catheter
US5395316A (en) 1993-08-11 1995-03-07 Med-Pro Design, Inc. Triple lumen catheter
US5399168A (en) 1991-08-29 1995-03-21 C. R. Bard, Inc. Implantable plural fluid cavity port
US5403274A (en) 1993-03-15 1995-04-04 Cannon; Louis A. Perfusion catheter and method of use
US5405341A (en) 1993-06-03 1995-04-11 Med-Pro Design, Inc. Catheter with multiple lumens
US5405320A (en) 1990-01-08 1995-04-11 The Curators Of The University Of Missouri Multiple lumen catheter for hemodialysis
US5451233A (en) 1986-04-15 1995-09-19 Yock; Paul G. Angioplasty apparatus facilitating rapid exchanges
US5486159A (en) 1993-10-01 1996-01-23 Mahurkar; Sakharam D. Multiple-lumen catheter
US5505710A (en) 1994-08-22 1996-04-09 C. R. Bard, Inc. Telescoping probe
EP0711574A1 (en) 1994-11-10 1996-05-15 Med-Pro Design, Inc. Catheter with dual round lumens
US5569182A (en) 1990-01-08 1996-10-29 The Curators Of The University Of Missouri Clot resistant multiple lumen catheter and method
US5571093A (en) 1994-09-21 1996-11-05 Cruz; Cosme Multiple-lumen catheter
WO1997006845A1 (en) 1995-08-14 1997-02-27 Act Medical, Inc. Catheter
US5607462A (en) 1993-09-24 1997-03-04 Cardiac Pathways Corporation Catheter assembly, catheter and multi-catheter introducer for use therewith
US5616137A (en) 1995-02-22 1997-04-01 Minnesota Mining And Manufacturing Company Low velocity aortic cannula
US5624392A (en) 1990-05-11 1997-04-29 Saab; Mark A. Heat transfer catheters and methods of making and using same
WO1997017102A1 (en) 1995-11-09 1997-05-15 Jendrisak Martin D Hemodialysis catheter
US5643226A (en) 1993-02-24 1997-07-01 Minnesota Mining And Manufacturing Low velocity aortic cannula
US5665067A (en) 1994-02-28 1997-09-09 Immuno Aktiengesellschaft Apparatus for applying a multiple-component tissue adhesive
US5685865A (en) 1993-02-24 1997-11-11 Minnesota Mining And Manufacturing Company Low velocity aortic cannula
US5693030A (en) 1995-06-28 1997-12-02 Lee, Lee & Beal, Inc. Catheter and method of introduction
US5718678A (en) 1996-06-26 1998-02-17 Medical Components, Inc. Multi-lumen coaxial catheter and method for making same
US5718692A (en) 1995-06-06 1998-02-17 Twineath, L.L.C. Self-retaining single insertion double catheter assembly and method for making double catheter systems
US5738649A (en) 1996-04-16 1998-04-14 Cardeon Corporation Peripheral entry biventricular catheter system for providing access to the heart for cardiopulmonary surgery or for prolonged circulatory support of the heart
US5743891A (en) 1996-10-25 1998-04-28 Act Medical, Inc. Subcutaneous safety catheter assembly
US5769828A (en) 1996-06-13 1998-06-23 Medtronic, Inc. Two-stage venous cannula with expandable reinforcing member
US5776111A (en) 1996-11-07 1998-07-07 Medical Components, Inc. Multiple catheter assembly
US5792094A (en) 1991-07-16 1998-08-11 Heartport, Inc. Method of delivering cardioplegic fluid to a patient's heart
US5800384A (en) 1993-10-08 1998-09-01 Medical Parameters, Inc. Multi-lumen percutaneous introducer
US5800414A (en) 1996-10-18 1998-09-01 Synthelabo Catheter with flexible and elongate body
US5807318A (en) 1994-07-28 1998-09-15 Heartport, Inc. Method of perfusing the coronary vasculature
US5807311A (en) 1996-11-29 1998-09-15 Palestrant; Aubrey M. Dialysis catheter having rigid and collapsible lumens and related method
US5810789A (en) 1996-04-05 1998-09-22 C. R. Bard, Inc. Catheters with novel lumen shapes
US5814016A (en) 1991-07-16 1998-09-29 Heartport, Inc. Endovascular system for arresting the heart
US5833671A (en) 1996-06-17 1998-11-10 Cardeon Corporation Triple lumen catheter with controllable antegrade and retrograde fluid flow
US5947953A (en) 1997-08-06 1999-09-07 Hemocleanse, Inc. Splittable multiple catheter assembly and methods of inserting the same
US5976103A (en) 1991-09-26 1999-11-02 Vas-Cath Incorporated Dual lumen coaxial catheter
US5989206A (en) 1997-10-31 1999-11-23 Biolink Corporation Apparatus and method for the dialysis of blood
US6001079A (en) 1995-09-05 1999-12-14 Pourchez; Thierry Multilumen catheter, particularly for hemodialysis
US6126631A (en) 1994-04-04 2000-10-03 Wake Forest University Multi-lumen catheter system used in a blood treatment process
US6156016A (en) 1998-01-06 2000-12-05 Maginot Vascular Systems Catheter systems and associated methods utilizing removable inner catheter or catheters
US6161547A (en) 1999-01-15 2000-12-19 Coaxia, Inc. Medical device for flow augmentation in patients with occlusive cerebrovascular disease and methods of use
US6217527B1 (en) 1998-09-30 2001-04-17 Lumend, Inc. Methods and apparatus for crossing vascular occlusions
US6280423B1 (en) 1998-02-24 2001-08-28 Scimed Life Systems, Inc. High flow rate dialysis catheters and related methods
US6293927B1 (en) 1997-07-24 2001-09-25 Rex Medical Stationary central tunnel dialysis catheter with optional separable sheath
US6387087B1 (en) 1996-12-11 2002-05-14 Ronald K. Grooters Aortic cannula
US20020087108A1 (en) 1999-01-15 2002-07-04 Maginot Paul J. Retractable catheter systems and associated methods
US20020091362A1 (en) 1998-01-06 2002-07-11 Maginot Thomas J. Medical procedure using catheter system having removability feature
US20020099327A1 (en) 2001-01-24 2002-07-25 Wilson Jon S. Multi-lumen catheter with attachable hub
US6443922B1 (en) 1997-01-24 2002-09-03 Heartport, Inc. Methods and devices for maintaining cardiopulmonary bypass and arresting a patient's heart
US20020183781A1 (en) 2001-04-17 2002-12-05 Brendan Casey Catheter
US20020188167A1 (en) 2001-06-06 2002-12-12 Anthony Viole Multilumen catheter for minimizing limb ischemia
US20030032918A1 (en) 2000-08-30 2003-02-13 Quinn David G. Catheter
US6540714B1 (en) 1999-11-24 2003-04-01 Radius International Limited Partnership Blood vessel catheter
US20030088213A1 (en) 2001-10-15 2003-05-08 Timothy Schweikert Catheter with detachable hub
US20030093029A1 (en) 2001-01-09 2003-05-15 Rex Medical Dialysis catheter
US20030093027A1 (en) 2001-01-09 2003-05-15 Mcguckin James F. Dialysis catheter
US20030149395A1 (en) 2002-02-07 2003-08-07 C.R. Bard, Inc. Split tip dialysis catheter
US20030153898A1 (en) 2000-06-01 2003-08-14 Schon Donald A. Multilumen catheter and methods for making the catheter
US20030187411A1 (en) 2002-03-18 2003-10-02 Constantz Brent R. Multilumen catheters and methods for their use
US6682519B1 (en) 2000-06-01 2004-01-27 Medical Components, Inc. Method for inserting a multiple catheter assembly
US6712797B1 (en) 2000-09-19 2004-03-30 Board Of Supervisors Of Louisiana State University And Agricultural And Mechanical College Blood return catheter
US6723084B1 (en) 1999-01-15 2004-04-20 Maginot Catheter Technologies, Inc. Catheter systems having multilumen guide catheter and retractable working catheter positioned in at least one lumen thereof
US20040075198A1 (en) 2000-06-01 2004-04-22 Schweikert Timothy M. Multilumen catheter assembly and methods for making and inserting the same
US6786884B1 (en) 1999-10-29 2004-09-07 Bard Access Systems, Inc. Bolus tip design for a multi-lumen catheter
US20040182102A1 (en) 2003-03-12 2004-09-23 Castel Mac S.P.A. Ice-making apparatus
US20040193102A1 (en) 2003-03-28 2004-09-30 Kurt Haggstrom Catheter with occlusion resistant tip
US6814718B2 (en) 2001-01-09 2004-11-09 Rex Medical, L.P Dialysis catheter
US20050033222A1 (en) 2003-03-28 2005-02-10 Kurt Haggstrom Triple lumen catheter with occlusion resistant tip
US20060004325A1 (en) 2004-07-02 2006-01-05 Bret Hamatake Tip configurations for a multi-lumen catheter

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4583968A (en) 1983-10-03 1986-04-22 Mahurkar Sakharam D Smooth bore double lumen catheter
US4795439A (en) * 1986-06-06 1989-01-03 Edward Weck Incorporated Spiral multi-lumen catheter
US4894067A (en) * 1987-11-18 1990-01-16 Carbumatic B.V. Low profile gaseous fuel carburetor
US4935004A (en) 1988-12-20 1990-06-19 Henry Ford Health System Peritoneal dialysis catheter
AU1866197A (en) * 1996-02-26 1997-09-16 Guihua Wang New type of easy-to-use electronic calculator
US6685867B2 (en) * 2001-09-05 2004-02-03 The Goodyear Tire & Rubber Company Method and apparatus for lugged strip removal
US8591450B2 (en) * 2010-06-07 2013-11-26 Rex Medical L.P. Dialysis catheter

Patent Citations (161)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US1696018A (en) 1926-07-10 1928-12-18 Schellberg Oscar Boto Colonic theraphy apparatus
US2393002A (en) 1944-05-03 1946-01-15 Smith Minton Larkin Kidney catheter
US3256885A (en) 1963-06-26 1966-06-21 Roehr Products Company Inc Aspirating device
US3416532A (en) 1964-07-24 1968-12-17 Grossman Alan Richard Drainage tube with means for scraping away debris therewithin
US3426759A (en) 1966-04-04 1969-02-11 Davol Inc Abdominal suction drainage tube
US3812851A (en) 1972-11-21 1974-05-28 P Rodriguez I. v. arm rest and support
US3929126A (en) 1974-09-26 1975-12-30 Jay C Corsaut Surgical suction irrigator
US3995623A (en) 1974-12-23 1976-12-07 American Hospital Supply Corporation Multipurpose flow-directed catheter
US4149535A (en) 1976-05-06 1979-04-17 Gist-Brocades N.V. Catheter holding device
US4072146A (en) 1976-09-08 1978-02-07 Howes Randolph M Venous catheter device
US4129129A (en) 1977-03-18 1978-12-12 Sarns, Inc. Venous return catheter and a method of using the same
US4180068A (en) 1978-04-13 1979-12-25 Motion Control, Incorporated Bi-directional flow catheter with retractable trocar/valve structure
US4493696A (en) 1979-12-28 1985-01-15 Allentyne Limited Hemodialysis cannular for subclavian insertion
US4385631A (en) 1980-03-21 1983-05-31 Ulrich Uthmann Catheter
US4557261A (en) 1980-12-20 1985-12-10 Ruegheimer Erich Connection system for fluid lines having telescoping connecting elements, in particular for respirators or anesthetic units
US4406656A (en) 1981-06-01 1983-09-27 Brack Gillium Hattler Venous catheter having collapsible multi-lumens
US4583986A (en) 1981-07-20 1986-04-22 Combe Incorporated Catalyzed bismuth dye system for human hair
US4451252A (en) 1981-07-24 1984-05-29 Vas-Cath Of Canada Limited Cannula
US4626240A (en) 1981-11-06 1986-12-02 Shiley Incorporated Dual lumen subclavian cannula
US4468216A (en) 1982-05-20 1984-08-28 Rudolph Muto Irrigation suction catheter
US4666426A (en) 1984-01-12 1987-05-19 Karl Aigner Double lumen catheter for a device for in-vivo purification of blood
US4682978A (en) 1984-05-24 1987-07-28 Vas-Cath Of Canada Limited Dual lumen cannula
US4643711A (en) 1984-05-25 1987-02-17 Cook, Inc. Two lumen hemodialysis catheter
US4563180A (en) 1984-06-29 1986-01-07 Raychem Corporation High flow catheter for injecting fluids
US4842582A (en) 1985-02-12 1989-06-27 Mahurkar Sakharam D Method and apparatus for using dual-lumen catheters for extracorporeal treatment
US4668221A (en) 1985-03-28 1987-05-26 Luther Medical Products, Inc. Assembly of stylet and catheter
US4687471A (en) 1985-05-01 1987-08-18 Curators Of The University Of Missouri Peritoneal dialysis catheter
US4772269A (en) 1985-05-01 1988-09-20 Curators Of The University Of Missouri Peritoneal dialysis catheter
US4772269B1 (en) 1985-05-01 1992-05-19 Univ Missouri
US4681564A (en) 1985-10-21 1987-07-21 Landreneau Michael D Catheter assembly having balloon extended flow path
US4681570A (en) 1985-12-26 1987-07-21 Dalton Michael J Peritoneal catheter
US4808155A (en) 1986-02-27 1989-02-28 Mahurkar Sakharam D Simple double lumen catheter
US5451233A (en) 1986-04-15 1995-09-19 Yock; Paul G. Angioplasty apparatus facilitating rapid exchanges
US4867742A (en) 1986-06-06 1989-09-19 Reynaldo Calderon Retrograde perfusion
US4755176A (en) 1987-06-11 1988-07-05 Patel Piyush V Catheter with side hole
US4894057A (en) 1987-06-19 1990-01-16 Howes Randolph M Flow enhanced multi-lumen venous catheter device
US4863441A (en) 1987-07-17 1989-09-05 Minnesota Mining And Manufacturing Company Venous return catheter
US5195962A (en) 1987-12-22 1993-03-23 Vas-Cath Incorporated Triple lumen catheter
US6206849B1 (en) 1987-12-22 2001-03-27 Vas-Cath Incorporated Multiple lumen catheter
US5135599A (en) 1987-12-22 1992-08-04 Vas-Cath Incorporated Method of making a triple lumen catheter
US5797869A (en) 1987-12-22 1998-08-25 Vas-Cath Incorporated Multiple lumen catheter
US5472417A (en) 1987-12-22 1995-12-05 Vas-Cath Incorporated Triple lumen catheter
US4935044A (en) 1988-03-01 1990-06-19 Linde Aktiengesellschaft Purification of crude argon
US4981477A (en) 1988-04-16 1991-01-01 Rudolf Schon Catheter for introduction into the trachea and the bronchial system
US5188593A (en) 1988-04-21 1993-02-23 Vas-Cath Incorporated Dual lumen catheter
US4961809A (en) 1988-04-21 1990-10-09 Vas-Cath Incorporated Method of producing a dual lumen catheter including forming a flare
US5057073A (en) 1988-04-21 1991-10-15 Vas-Cath Incorporated Dual lumen catheter
US4895561A (en) 1988-05-16 1990-01-23 Mahurkar Sakharam D Dual-lumen catheter-connecting system
US5053023A (en) 1988-10-25 1991-10-01 Vas-Cath Incorporated Catheter for prolonged access
US5015230A (en) 1989-01-30 1991-05-14 Vas-Cath Incorporated Angioplasty catheter with spiral balloon
US5226880A (en) 1989-01-31 1993-07-13 Vas-Cath Incorporated Angioplasty catheter with balloon retainer
US4995865A (en) 1989-06-09 1991-02-26 Worldwide Medical Plastics Inc. Multi-lumen catheters
US5106376A (en) 1989-07-07 1992-04-21 B. Braun Melsungen Ag Anaesthesia set
US4985014A (en) 1989-07-11 1991-01-15 Orejola Wilmo C Ventricular venting loop
US5171216A (en) 1989-08-28 1992-12-15 Thermedics, Inc. Multi-lumen catheter coupling
US5041107A (en) 1989-10-06 1991-08-20 Cardiac Pacemakers, Inc. Electrically controllable, non-occluding, body implantable drug delivery system
WO1991006845A2 (en) 1989-10-27 1991-05-16 American Tech Manufacturing, Corp. Coplanarity inspection machine
US5569182A (en) 1990-01-08 1996-10-29 The Curators Of The University Of Missouri Clot resistant multiple lumen catheter and method
US5685867A (en) 1990-01-08 1997-11-11 The Curators Of The University Of Missouri Clot resistant multiple lumen catheter
US5405320A (en) 1990-01-08 1995-04-11 The Curators Of The University Of Missouri Multiple lumen catheter for hemodialysis
US5509897A (en) 1990-01-08 1996-04-23 The Curators Of The University Of Missouri Multiple lumen catheter for hemodialysis
US5209723A (en) 1990-01-08 1993-05-11 The Curators Of The University Of Missouri Multiple lumen catheter for hemodialysis
US5374245A (en) 1990-01-10 1994-12-20 Mahurkar; Sakharam D. Reinforced multiple-lumen catheter and apparatus and method for making the same
US5221255A (en) 1990-01-10 1993-06-22 Mahurkar Sakharam D Reinforced multiple lumen catheter
US5156592A (en) 1990-04-04 1992-10-20 Martin Geoffrey S Pre-curved dual lumen catheter
US5624392A (en) 1990-05-11 1997-04-29 Saab; Mark A. Heat transfer catheters and methods of making and using same
US5053004A (en) 1990-08-24 1991-10-01 Medical Components, Inc. Catheter having two coaxial lumens
US5190520A (en) 1990-10-10 1993-03-02 Strato Medical Corporation Reinforced multiple lumen catheter
EP0495263A1 (en) 1990-12-27 1992-07-22 The Kendall Company Multilumen catheter
US5167623A (en) 1990-12-27 1992-12-01 The Kendall Company Multilumen catheter
US5171227A (en) 1991-04-16 1992-12-15 The Curators Of The University Of Missouri Separable peritoneal dialysis catheter
US5814016A (en) 1991-07-16 1998-09-29 Heartport, Inc. Endovascular system for arresting the heart
US5792094A (en) 1991-07-16 1998-08-11 Heartport, Inc. Method of delivering cardioplegic fluid to a patient's heart
US5399168A (en) 1991-08-29 1995-03-21 C. R. Bard, Inc. Implantable plural fluid cavity port
US5976103A (en) 1991-09-26 1999-11-02 Vas-Cath Incorporated Dual lumen coaxial catheter
US5215527A (en) 1991-12-12 1993-06-01 Becton, Dickinson And Company Catheter introducer assembly
US5221256A (en) 1992-02-10 1993-06-22 Mahurkar Sakharam D Multiple-lumen catheter
US5242398A (en) 1992-03-12 1993-09-07 Knoll Charles L Catheter assembly and related method
US5324274A (en) 1992-03-30 1994-06-28 Med-Pro Design, Inc. Catheter having rotary valves
US5472432A (en) 1992-03-30 1995-12-05 Med-Pro Design, Inc. Catheter having rotary valves
US5350358A (en) 1992-12-22 1994-09-27 Med-Pro Design, Inc. Bent co-axial catheter
US5643226A (en) 1993-02-24 1997-07-01 Minnesota Mining And Manufacturing Low velocity aortic cannula
US5685865A (en) 1993-02-24 1997-11-11 Minnesota Mining And Manufacturing Company Low velocity aortic cannula
US5403274A (en) 1993-03-15 1995-04-04 Cannon; Louis A. Perfusion catheter and method of use
US5346471A (en) 1993-03-22 1994-09-13 Raulerson J Daniel Dual lumen catheter
US5405341A (en) 1993-06-03 1995-04-11 Med-Pro Design, Inc. Catheter with multiple lumens
US5451206A (en) 1993-08-02 1995-09-19 Quinton Instrument Company Triple lumen catheter
US5348536A (en) 1993-08-02 1994-09-20 Quinton Instrument Company Coextruded catheter and method of forming
US5395316A (en) 1993-08-11 1995-03-07 Med-Pro Design, Inc. Triple lumen catheter
US5607462A (en) 1993-09-24 1997-03-04 Cardiac Pathways Corporation Catheter assembly, catheter and multi-catheter introducer for use therewith
US5342295A (en) 1993-09-24 1994-08-30 Cardiac Pathways Corporation Catheter assembly, catheter and multi-port introducer for use therewith
US5486159A (en) 1993-10-01 1996-01-23 Mahurkar; Sakharam D. Multiple-lumen catheter
US5800384A (en) 1993-10-08 1998-09-01 Medical Parameters, Inc. Multi-lumen percutaneous introducer
US5378230A (en) 1993-11-01 1995-01-03 Mahurkar; Sakharam D. Triple-lumen critical care catheter
US5665067A (en) 1994-02-28 1997-09-09 Immuno Aktiengesellschaft Apparatus for applying a multiple-component tissue adhesive
US6126631A (en) 1994-04-04 2000-10-03 Wake Forest University Multi-lumen catheter system used in a blood treatment process
US5807318A (en) 1994-07-28 1998-09-15 Heartport, Inc. Method of perfusing the coronary vasculature
US5505710A (en) 1994-08-22 1996-04-09 C. R. Bard, Inc. Telescoping probe
US5571093A (en) 1994-09-21 1996-11-05 Cruz; Cosme Multiple-lumen catheter
EP0711574A1 (en) 1994-11-10 1996-05-15 Med-Pro Design, Inc. Catheter with dual round lumens
US5961486A (en) 1995-02-09 1999-10-05 Twardowski; Zbylut J. Clot resistant multiple lumen catheter
US5616137A (en) 1995-02-22 1997-04-01 Minnesota Mining And Manufacturing Company Low velocity aortic cannula
US5718692A (en) 1995-06-06 1998-02-17 Twineath, L.L.C. Self-retaining single insertion double catheter assembly and method for making double catheter systems
US5693030A (en) 1995-06-28 1997-12-02 Lee, Lee & Beal, Inc. Catheter and method of introduction
WO1997006845A1 (en) 1995-08-14 1997-02-27 Act Medical, Inc. Catheter
US6001079A (en) 1995-09-05 1999-12-14 Pourchez; Thierry Multilumen catheter, particularly for hemodialysis
WO1997017102A1 (en) 1995-11-09 1997-05-15 Jendrisak Martin D Hemodialysis catheter
US5810789A (en) 1996-04-05 1998-09-22 C. R. Bard, Inc. Catheters with novel lumen shapes
US5738649A (en) 1996-04-16 1998-04-14 Cardeon Corporation Peripheral entry biventricular catheter system for providing access to the heart for cardiopulmonary surgery or for prolonged circulatory support of the heart
US5769828A (en) 1996-06-13 1998-06-23 Medtronic, Inc. Two-stage venous cannula with expandable reinforcing member
US5833671A (en) 1996-06-17 1998-11-10 Cardeon Corporation Triple lumen catheter with controllable antegrade and retrograde fluid flow
US5718678A (en) 1996-06-26 1998-02-17 Medical Components, Inc. Multi-lumen coaxial catheter and method for making same
US5800414A (en) 1996-10-18 1998-09-01 Synthelabo Catheter with flexible and elongate body
WO1998017337A1 (en) 1996-10-25 1998-04-30 Act Medical, Inc. Subcutaneous safety catheter assembly
US5743891A (en) 1996-10-25 1998-04-28 Act Medical, Inc. Subcutaneous safety catheter assembly
US5776111A (en) 1996-11-07 1998-07-07 Medical Components, Inc. Multiple catheter assembly
US5807311A (en) 1996-11-29 1998-09-15 Palestrant; Aubrey M. Dialysis catheter having rigid and collapsible lumens and related method
US6387087B1 (en) 1996-12-11 2002-05-14 Ronald K. Grooters Aortic cannula
US6443922B1 (en) 1997-01-24 2002-09-03 Heartport, Inc. Methods and devices for maintaining cardiopulmonary bypass and arresting a patient's heart
US6293927B1 (en) 1997-07-24 2001-09-25 Rex Medical Stationary central tunnel dialysis catheter with optional separable sheath
US5947953A (en) 1997-08-06 1999-09-07 Hemocleanse, Inc. Splittable multiple catheter assembly and methods of inserting the same
US6190349B1 (en) 1997-08-06 2001-02-20 Hemocleanse, Inc. Splittable multiple catheter assembly and methods for inserting the same
US5989206A (en) 1997-10-31 1999-11-23 Biolink Corporation Apparatus and method for the dialysis of blood
US6620118B1 (en) 1997-10-31 2003-09-16 Biolink Corporation Apparatus and method for the dialysis of blood
US20020091362A1 (en) 1998-01-06 2002-07-11 Maginot Thomas J. Medical procedure using catheter system having removability feature
US6156016A (en) 1998-01-06 2000-12-05 Maginot Vascular Systems Catheter systems and associated methods utilizing removable inner catheter or catheters
US6280423B1 (en) 1998-02-24 2001-08-28 Scimed Life Systems, Inc. High flow rate dialysis catheters and related methods
US6217527B1 (en) 1998-09-30 2001-04-17 Lumend, Inc. Methods and apparatus for crossing vascular occlusions
US6723084B1 (en) 1999-01-15 2004-04-20 Maginot Catheter Technologies, Inc. Catheter systems having multilumen guide catheter and retractable working catheter positioned in at least one lumen thereof
US6161547A (en) 1999-01-15 2000-12-19 Coaxia, Inc. Medical device for flow augmentation in patients with occlusive cerebrovascular disease and methods of use
US20020087108A1 (en) 1999-01-15 2002-07-04 Maginot Paul J. Retractable catheter systems and associated methods
US6786884B1 (en) 1999-10-29 2004-09-07 Bard Access Systems, Inc. Bolus tip design for a multi-lumen catheter
US6540714B1 (en) 1999-11-24 2003-04-01 Radius International Limited Partnership Blood vessel catheter
US20040075198A1 (en) 2000-06-01 2004-04-22 Schweikert Timothy M. Multilumen catheter assembly and methods for making and inserting the same
US20040059314A1 (en) 2000-06-01 2004-03-25 Schon Donald A. Multilumen catheter and methods for making the catheter
US20040054321A1 (en) 2000-06-01 2004-03-18 Schon Donald A. Splittable a multilumen catheter assembly
US6695832B2 (en) 2000-06-01 2004-02-24 Twincath, Llc Multilumen catheter and methods for making the catheter
US6682519B1 (en) 2000-06-01 2004-01-27 Medical Components, Inc. Method for inserting a multiple catheter assembly
US20030153898A1 (en) 2000-06-01 2003-08-14 Schon Donald A. Multilumen catheter and methods for making the catheter
US20030032918A1 (en) 2000-08-30 2003-02-13 Quinn David G. Catheter
US6712797B1 (en) 2000-09-19 2004-03-30 Board Of Supervisors Of Louisiana State University And Agricultural And Mechanical College Blood return catheter
US20030093027A1 (en) 2001-01-09 2003-05-15 Mcguckin James F. Dialysis catheter
US7077829B2 (en) 2001-01-09 2006-07-18 Rex Medical, L.P. Dialysis catheter
US7074213B2 (en) 2001-01-09 2006-07-11 Rex Medical, L.P. Dialysis catheter
US20030093029A1 (en) 2001-01-09 2003-05-15 Rex Medical Dialysis catheter
US6814718B2 (en) 2001-01-09 2004-11-09 Rex Medical, L.P Dialysis catheter
US20050131341A1 (en) 2001-01-09 2005-06-16 Rex Medical, L.P. Dialysis catheter
US6858019B2 (en) 2001-01-09 2005-02-22 Rex Medical, L.P. Dialysis catheter and methods of insertion
US6638242B2 (en) 2001-01-24 2003-10-28 Jon S. Wilson Multi-lumen catheter with attachable hub
US20040065333A1 (en) 2001-01-24 2004-04-08 Wilson Jon S. Multi-lumen catheter with attachable hub
US20020099327A1 (en) 2001-01-24 2002-07-25 Wilson Jon S. Multi-lumen catheter with attachable hub
US20020183781A1 (en) 2001-04-17 2002-12-05 Brendan Casey Catheter
US20020188167A1 (en) 2001-06-06 2002-12-12 Anthony Viole Multilumen catheter for minimizing limb ischemia
US20030088213A1 (en) 2001-10-15 2003-05-08 Timothy Schweikert Catheter with detachable hub
US20030149395A1 (en) 2002-02-07 2003-08-07 C.R. Bard, Inc. Split tip dialysis catheter
US20030187411A1 (en) 2002-03-18 2003-10-02 Constantz Brent R. Multilumen catheters and methods for their use
US20040182102A1 (en) 2003-03-12 2004-09-23 Castel Mac S.P.A. Ice-making apparatus
US20050033222A1 (en) 2003-03-28 2005-02-10 Kurt Haggstrom Triple lumen catheter with occlusion resistant tip
US20040193102A1 (en) 2003-03-28 2004-09-30 Kurt Haggstrom Catheter with occlusion resistant tip
US20060004325A1 (en) 2004-07-02 2006-01-05 Bret Hamatake Tip configurations for a multi-lumen catheter
US8323227B2 (en) 2004-07-02 2012-12-04 C. R. Bard, Inc. Tip configurations for a multi-lumen catheter

Non-Patent Citations (10)

* Cited by examiner, † Cited by third party
Title
PCT/US2005/023451 filed Jun. 30, 2005 International Preliminary Report on Patentability dated Jan. 9, 2007.
PCT/US2005/023451 filed Jun. 30, 2005 Search Report dated Oct. 2, 2006.
PCT/US2005/023451 filed Jun. 30, 2005 Written Opinion dated Oct. 2, 2006.
U.S. Appl. No. 10/884,291, filed Jul. 2, 2004 Advisory Action dated Oct. 27, 2009.
U.S. Appl. No. 10/884,291, filed Jul. 2, 2004 Decision on Appeal dated May 9, 2012.
U.S. Appl. No. 10/884,291, filed Jul. 2, 2004 Final Office Action dated Aug. 12, 2009.
U.S. Appl. No. 10/884,291, filed Jul. 2, 2004 Non-Final Office Action dated Feb. 27, 2007.
U.S. Appl. No. 10/884,291, filed Jul. 2, 2004 Non-Final Office Action dated Jan. 6, 2009.
U.S. Appl. No. 10/884,291, filed Jul. 2, 2004 Non-Final Office Action dated Jul. 8, 2008.
U.S. Appl. No. 10/884,291, filed Jul. 2, 2004 Notice of Allowance dated Aug. 7, 2012.

Cited By (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20140107591A1 (en) * 2004-07-02 2014-04-17 C. R. Bard, Inc. Tip Configurations for Multi-Lumen Catheter
US9656041B2 (en) * 2004-07-02 2017-05-23 C. R. Bard, Inc. Tip configurations for multi-lumen catheter
US9839763B2 (en) 2004-07-02 2017-12-12 C. R. Bard, Inc. Tip configurations for multi-lumen catheter
US10004842B2 (en) 2011-08-11 2018-06-26 Medical Components, Inc. Method and apparatus for the dialysis of blood
US10765794B2 (en) 2011-08-11 2020-09-08 Medical Components, Inc. Method and apparatus for the dialysis of blood
US10765795B2 (en) 2011-08-11 2020-09-08 Medical Components, Inc. Method and apparatus for the dialysis of blood
US11696981B2 (en) 2011-08-11 2023-07-11 Medical Components, Inc. Method and apparatus for the dialysis of blood
USD905853S1 (en) 2018-02-27 2020-12-22 Medical Components, Inc. Catheter tip
USD984880S1 (en) 2020-11-06 2023-05-02 Medical Components, Inc. Clamp with indicator

Also Published As

Publication number Publication date
US8323227B2 (en) 2012-12-04
US20130085436A1 (en) 2013-04-04
JP2008504897A (en) 2008-02-21
WO2006014339A3 (en) 2006-12-07
US20150073327A1 (en) 2015-03-12
US9656041B2 (en) 2017-05-23
US20060004325A1 (en) 2006-01-05
US9839763B2 (en) 2017-12-12
WO2006014339A2 (en) 2006-02-09
US20140107591A1 (en) 2014-04-17

Similar Documents

Publication Publication Date Title
US9839763B2 (en) Tip configurations for multi-lumen catheter
US8920404B2 (en) Reduction of recirculation in catheters
EP0322225B1 (en) Triple lumen catheter
CA2480465C (en) A multilumen catheter for minimizing limb ischemia
AU706109B2 (en) Clot resistant multiple lumen catheter
US10058676B2 (en) Medical catheter having a design providing low recirculation and reversibility
US6682498B2 (en) Methods and systems for subcutaneous graft implantation
US6126631A (en) Multi-lumen catheter system used in a blood treatment process
US7008395B1 (en) Multi-lumen catheter system used in a blood treatment process
EP1694377B1 (en) Catheter button hub
JP2011502583A (en) Catheter assembly including triple lumen end
CN112933373B (en) Multi-lumen indwelling catheter
CN103028186A (en) Catheter with external flow channel
WO2009131583A1 (en) Catheter with open faced beveled tip
JPH02209159A (en) Multiple lumen catheter and making thereof
AU2008200502A1 (en) A Multilumen Catheter for Minimizing Limb Ischemia

Legal Events

Date Code Title Description
STCF Information on status: patent grant

Free format text: PATENTED CASE

MAFP Maintenance fee payment

Free format text: PAYMENT OF MAINTENANCE FEE, 4TH YEAR, LARGE ENTITY (ORIGINAL EVENT CODE: M1551)

Year of fee payment: 4

MAFP Maintenance fee payment

Free format text: PAYMENT OF MAINTENANCE FEE, 8TH YEAR, LARGE ENTITY (ORIGINAL EVENT CODE: M1552); ENTITY STATUS OF PATENT OWNER: LARGE ENTITY

Year of fee payment: 8