|Numéro de publication||US9629672 B2|
|Type de publication||Octroi|
|Numéro de demande||US 14/749,897|
|Date de publication||25 avr. 2017|
|Date de dépôt||25 juin 2015|
|Date de priorité||13 avr. 2011|
|Autre référence de publication||EP2696784A2, EP2696784A4, US9095387, US20120265203, US20150289909, US20170189087, WO2012142361A2, WO2012142361A3|
|Numéro de publication||14749897, 749897, US 9629672 B2, US 9629672B2, US-B2-9629672, US9629672 B2, US9629672B2|
|Inventeurs||Christopher Angelucci, Michael Black, Brian Garvey, James Himmelberger, Colm McLaughlin, Robert W. Trout|
|Cessionnaire d'origine||Globus Medical, Inc.|
|Exporter la citation||BiBTeX, EndNote, RefMan|
|Citations de brevets (82), Classifications (6), Événements juridiques (1)|
|Liens externes: USPTO, Cession USPTO, Espacenet|
This application is a continuation application of U.S. patent application Ser. No. 13/086,122, filed Apr. 13, 2011, which is hereby incorporated by reference in its entirety.
The invention relates to bone fixation, and more particularly to fixation of spinal joints using compression imposed by mating plates.
Spinal fusion, also known as spondylodesis or spondylosyndesis, is a surgical technique used to join two or more vertebrae. Supplementary bone tissue, from the patient (autograft), a donor (allograft), or from a synthetic material can be used in conjunction with the body's natural bone growth (osteoblastic) processes to fuse the vertebrae.
Wolfe's Law states that maintaining a compressive load on a graft in an interbody fusion contributes towards the graft fusing more quickly and or thoroughly.
An embodiment for stabilizing bones of a patient comprises a first plate portion including at least one aperture for connecting the first plate portion to body tissue of the patient comprises a projection extending from the first plate portion; a second plate portion including at least one aperture for connecting the second plate portion to body tissue of the patient; a chamber formed in the second plate portion sized and dimensioned to slidingly receive the projection, thereby substantially limiting movement of the first plate portion relative to the second plate portion to a telescoping motion when the projection is received within the chamber; a limiter resiliently extending from one of the projection or the chamber; a catch formed in the other of the projection or the chamber, relative to the limiter, operative to form an engagement with the limiter, the catch further operative to admit passage of the limiter past the engagement when the first and second plate portions are telescoped together, the catch further operative to prevent passage of the limiter past the engagement of the catch and the limiter when the first and second plate portions are telescoped apart.
In further embodiments, the projection forms at least two rails engageable with the chamber; the chamber forms at least two grooves mateable with the at least two rails; a groove formed in the projection or chamber forming the catch is positioned apart from a location of the engagement when the first and second plate portions are telescoped together, the groove operative to admit passage of the limiter between a first location at a first distance from the engagement and a second location disposed at a distance from the first location; an aperture is formed in the projection or chamber forming the catch, whereby an object may be inserted within the aperture to resiliently bend the limiter to disengage the limiter from the catch.
In yet further embodiments, an aperture is formed in the projection or chamber forming the catch, whereby an object may be inserted within the aperture to resiliently bend the limiter to disengage the limiter from the groove; and the limiter has a ramped surface and a blocking surface; the catch further includes a blocking surface, the blocking surface of the limiter mateably engageable with the blocking surface of the catch to prevent telescoping apart of the first plate portion and the second plate portion.
In another embodiment, the bones of the patient are jointed bones, and the first plate portion is engageable with bones of a first side of the joint, and the second plate portion is engageable with bones on a second, opposite side of the joint; when the first plate portion and the second plate portion are telescoped together, a compressive force is applied to the jointed bones; the compressive force is operative to promote a fusion of bones of the patient; the limiter forms a curved profile mateable with a curved profile of the catch; the chamber further includes a viewing aperture positioned formed in the chamber and operative to enable viewing of an extent of telescoping of the first plate portion with the second plate portion; and the viewing aperture includes formations enabling a quantification of an extent of telescoping of the first and second plate portions.
In yet another embodiment, a device for applying a compressive force to separated bones of a patient, comprises a first plate portion including at least one aperture for connecting the first plate portion to a first bone of the patient; a projection extending from the first plate portion; a second plate portion including at least one aperture for connecting the second plate portion to a second bone of the patient, the second bone separated from the first bone by a bone graft; a chamber formed in the second plate portion sized and dimensioned to slidingly receive the projection, thereby substantially limiting movement of the first plate portion relative to the second plate portion to a telescoping motion when the projection is received within the chamber; a catch formed in one of the projection or the chamber, operative to form an engagement with the limiter, the catch further operative to admit passage of the limiter past the engagement when the first and second plate portions are telescoped together, the catch further operative to prevent passage of the limiter past the engagement of the catch and the limiter when the first and second plate portions are telescoped apart; a limiter resiliently extending from the other of the projection or the chamber relative to the catch, and having a surface angled to slidingly engage the catch, and an opposing surface angled to resist movement when engaged with the catch; and a groove is formed in the projection or chamber forming the catch, the groove positioned apart from a location of the engagement when the first and second plate portions are telescoped together, the groove operative to admit passage of the limiter between a first location at a first distance from the engagement and a second location disposed at a substantial distance from the first location.
In another embodiment, a device for applying a compressive force to separated bones of a patient comprises a first plate portion including at least one aperture for connecting the first plate portion to a first bone of the patient; a projection extending from the first plate portion; a second plate portion including at least one aperture for connecting the second plate portion to a second bone of the patient, the second bone separated from the first bone by a bone graft; a chamber formed in the second plate portion sized and dimensioned to slidingly receive the projection, thereby substantially limiting movement of the first plate portion relative to the second plate portion to a telescoping motion when the projection is received within the chamber; a catch formed in one of the projection or the chamber, operative to form an engagement with the limiter, the catch further operative to admit passage of the limiter past the engagement when the first and second plate portions are telescoped together, the catch further operative to prevent passage of the limiter past the engagement of the catch and the limiter when the first and second plate portions are telescoped apart; a limiter resiliently extending from the other of the projection or the chamber relative to the catch, and having a surface angled to slidingly engage the catch, and an opposing surface angled to resist movement when engaged with the catch; and a viewing aperture positioned in the chamber and operative to enable viewing of an extent of telescoping of the first plate portion with the second plate portion.
In a yet further embodiment, the limiter includes a relief formed in the projection or chamber from which the limiter extends, the limiter operative to resiliently bend and deflect into the relief.
A more complete understanding of the present invention, and the attendant advantages and features thereof, will be more readily understood by reference to the following detailed description when considered in conjunction with the accompanying drawings wherein:
In the description which follows, any reference to direction or orientation is intended primarily and solely for purposes of illustration and is not intended in any way as a limitation to the scope of the present invention. Also, the particular embodiments described herein are not to be considered as limiting of the present invention.
Referring now to the figures, in which like reference numerals refer to like elements,
With reference to
With further reference to
Additional apertures 210, 212, 310, 312 may be provided to operatively serve at least one of the following: engaging fasteners, provide an observation window to underlying areas, provide an access port to underlying tissue, provide an area to pack bone graft or other bone growth stimulating materials and/or releasably connect device 100 with surgical or manipulative instrumentation. Elongated aperture 314, visible in
It may be desired to allow receiver 200 and insert 300 to remain in mutual slideable engagement within the body. Therapeutic benefits would include restricting ranges of motion, for example flexion or extension, while enabling compression and distraction. In this application, it may be advantageous for fastener 316 to securely engage a portion 202, as by threading, compression, adhesion, or welding, whereby a post portion 320 of fastener 316 may freely slide within aperture 314 of insert 300. Alternatively, not shown, chamber 202 may be provided with an elongated aperture as shown for aperture 314, and a post 320 may be associated with insert 302.
In another application, it may be advantageous to fasten receiver 200 and or insert 300 to the body, therapeutically adjust a disposition of bones of the body, and then securely fasten receiver 200 and insert 300 in a fixed relative configuration. In this application, it may be advantageous to connect receiver 200 and insert 300 in slideable alignment, and expeditiously tighten receiver 200 and insert 200 together once a desired position has been attained. Accordingly, connector 220 may releasably engage fastener 316, for example by threaded attachment 222, whereby when post 320 passes through opening 216, through aperture 314, and into engagement with connector 220, receiver 200 and insert 300 may slide relative to each other, but not separate. When a disposition of bones has been achieved, fastener 316 may be securely fastened to connector 220, whereupon projection 302 is pinched against one or more surfaces of chamber 202, and may no longer slide relative to chamber 202. To promote a secure connection between projection 302 and chamber 202, a surface 224 of connector 220 may be provided with a knurled or roughened surface, as may a complementary contacting surface 324 of projection 302 and or chamber 202. For additional strength or reliability, a plurality of fasteners 316 and or connectors 220 may be used. A single fastener has an advantage of quick installation and adjustment, decreasing the duration of surgery.
Receiver 200 and insert 300 may advantageously be assembled and sterilized prior to surgery, together with fastener 316 and connector 220, for example as part of a manufacturing and quality control process, thereby facilitating surgical preparation by eliminating interoperative assembly, and reducing the complexity and duration of surgery, while reducing the probability of assembly error.
In yet another application, receiver 200 and insert 300 are mutually connected, and engaged to respective portions of body tissue. Subsequently, receiver 200 and insert 300 are each engaged by an instrument, not shown, for example through connection with one or more of aperture 310 of insert 300, and aperture 210, 212, or narrowed portion 226, of receiver 200. In this manner, receiver 200 and insert 300 may be compressed together, or expanded apart, thereby producing a commensurate change in the relative alignment of attached tissue, whereupon fastener 316 may then be tightened to maintain a desired alignment. A slot 230 may be provided, formed in a portion of chamber 202, operative to admit passage of a portion of fastener 316, to permit passage of body fluids or tissue ingrowth into chamber 202, to reduce weight of device 100, and or to facilitate attachment of connector 220.
Receiver 200 and insert 300 interconnect in sliding mutual engagement along a predetermined pathway which may be straight or curved, defined by mating rails 332 and grooves 232, each of rail 332 guided along a pathway defined by a respective groove 232. In this manner, telescoping movement of receiver 200 and insert 300 may be defined to a single plane or curved pathway, thereby enabling compression or distraction, while stabilizing along other axes. The mating rail 332 and groove 232 enable a bending or twisting load to be distributed across the length of mutual engagement of rails 332 and grooves 232, providing increased strength, reducing the incidence and severity of potential stress raisers, and preventing disengagement along an anterior-posterior direction when device 100 is implanted in the spine.
Receiver 200 and insert 300 are each provided with a narrowed portion 226, 326, respectively, advantageously sized to facilitate insertion of device 100 into the body through a percutaneous puncture or minimal incision, to provide good visualization of underlying tissues, and or to reduce impact upon surrounding tissues at the site of implantation. Further, head portions 228, 328 may be angled, and or provided with curved surfaces, to better conform to intended attachment surfaces in the body. As such, device 100 may be provided in left or right configurations, and may be provided in a range of sizes or configurations appropriate for the size, gender, or age of the patient. For each size, device 100 enables a low profile, or reduced dimensional size, thereby reducing dislocation of body tissue, facilitating implantation, and increasing patient comfort.
As a sliding or telescoping engagement is formed between receiver 200 and insert 300 at a location disposed away from bone engaging head portions 228, 328, greater flexibility in an orientation and shape of head portions 228, 328 is possible. In particular, portions of device 100 that interface with the spine may be contoured to match the natural anatomy of the vertebral bodies, without a requirement of slots or adjustments at these interface regions. Accordingly, an optimal configuration, for example, of apertures 206, 306 and associated locking mechanisms 208, 308, is achieved.
Device 100 may be used, for example, in the case of a trauma, tumor or deformity in the human spine where one or more vertebral bodies are compromised. In certain instances, it is advantageous to perform a corpectomy where the damaged portions of the vertebrae are removed. A cage or bone graft is inserted into the resulting space to replace the removed tissue. In addition to the cage or graft, device 100 is provided operative to span the now weakened area, and provide stabilization while tissues reform and native strength is restored, or as a longer term source of stabilization.
In an application, a compressive force is applied by device 100 to a bone graft or other implanted material, and or bones or other tissue of the patient, whereby Wolfe's Law may apply. After an initial implantation, an increase or decrease in compressive force may be achieved by loosening fastener 316, changing a disposition of body tissue, and refastening 316, for example through a minimally invasive procedure. Such increase in compressive force may advantageously compensate, for example, for graft subsidence.
Referring now to
Device 100A is illustrated in
Devices of the various embodiments disclosed herein enable a reduction or elimination of movement of a stabilizing plate relative to a bone screw or anchor head, thereby reducing disease caused by an implant element rubbing or contacting body tissue, including an adjacent disc.
With reference to
Where two or more limiters 534 are used, it is advantageous to ensure all limiters are engaged to their respective catches 634 at the same time. With appropriate design and manufacturing tolerances, the sliding coordination of rails 332 and grooves 232 reduces side to side, jamming, or toggling motions of receiver 200 and insert 300, which could otherwise enable an uneven engagement.
Projecting surface 536 is advantageously formed with a steeply angled surface 550 extending in a direction away from head portion 228, and a ramped surface extending in direction towards head portion 228. In this manner, when receiver 200 and insert 300 are assembled together, projecting surface may be deflected by catch 634 to resiliently bend extension 238 to admit passage of limiter 534 past catch 634. Similarly, the steeply angled surface of projecting surface 536 is thereafter constrained against a mating surface of catch 634 whereby extension 238 is not caused to bend, and maintenance of a mutual engagement of receiver 200 and insert 300 is thus fostered. A force required to bend extension 238 may be targeted to result in resistance to engagement of limiter 534 and catch 634 until a sufficient compressive force is applied to the receiver 200 and insert 300. In this manner, a device implanted with an unengaged limiter 534 may become engaged when a sufficient range of motion has been achieved, for example during therapeutic exercise, or after a predetermined extent of graft subsidence or tissue healing has occurred.
A groove or channel 240 may be seen in
In the operating theatre, receiver 200 is engaged with body tissue, for example a first vertebra, and insert 300, preassembled into receiver 200 and optionally retained therein by pin 342, is engaged with a different portion of body tissue, for example a second vertebra. Engagement of receiver 200 and insert 300 is by any known means, including screws, polyaxial screws, pedicle screws, bone screws, staples, clips, anchors, adhesive, suture, and or wire. Advantageously, graft material is placed into the body prior to engagement of device 100B.
Once receiver 200 and insert 300 are engaged with the body, tissue and or graft material positioned between engaged body portions may be compressed towards each other. In one embodiment, the body tissue is compressed using any known means, including directly engaging the body tissue. In another embodiment, receiver 200 and insert 300 are directly manipulated and moved closer together into further mutual sliding engagement, and through their respective connections with body tissue, cause the body tissue portions to move or to be compressed together. To facilitate this action, one or more engagement formations 244 in receiver 200, and or engagement formations 344 in insert 300, are operative to enable secure engagement with a compression instrument, not shown. Such compression instrument may be of a prior art design, for which device 100B is adapted, or an instrument may be adapted or created for engagement with specific engagement formations 244, 344 of device 100A. Engagement formations 244, 344 may have the form, for example, of depressions, projections, or apertures, and may be threaded or otherwise configured for secure engagement with a hand, and or an instrument or tool.
It is contemplated that an initial amount of compression engages limiter 534 and catch 634, whereby the body tissue portions may further compress, however a minimum amount of compression is continuously maintained, advantageously sufficient to exploit Wolfe's Law. Limiter grooves 646 may be provided to protect and guide limiters 534 during relative movement of receiver 200 and insert 300.
Aperture 212 is provided with indicating formations 246, spaced at regular intervals, for example 1 mm, although other intervals may advantageously be employed. Indicating formations may have the shape of a projection extending into aperture 212, or may be formed as one or more angled lines, as may be seen in
Referring now to
It may be advantageous to impose an initial amount of compression not only to encourage tissue growth, ingrowth, or fusion. An objective of a medical practitioner may be to insert an amount of graft or implant material sufficient to cause a desired amount of compression between body tissue and the implanted material, whereby surrounding body tissue, for example ligamentous tissue, provides the compressive force. However, if excess tissue is removed, or surrounding tissue does not create sufficient compression, the initial force imposed by engaging limiter 534 and catch 634 may provide the requisite compression. In addition, further compression may be imposed during flexion and extension of the joint. For example, receiver 200 and insert 300 may freely move further together due to natural kinematics of the joint.
While limiter 534 is shown and described as connected to receiver 200, it should be understood that catch 634 may be connected to receiver 200, and limiter 534 may be connected to insert 300. It is further noted that rails 332 and mating grooves 232 of device 100B are shaped with a different angle than corresponding rails 332 and grooves 232 of device 100A, although it should be understood that rails 332 and grooves 232 of device 100B may have the same or similar angle to that of device 100A.
Similarly, other features and corresponding advantages of the various embodiments herein may be interchanged or combined, as would be understood by one skilled in the art. More particularly, each embodiment of device 100 illustrates a particular combination of features, and for clarity, not all features or combination of features are illustrated for each device.
With reference to
Devices of the disclosure advantageously adjust for changes in graft height, postoperatively, as needed. In this manner, load may be maintained on graft of an interbody fusion to ensure that the graft is fused thoroughly and as quickly as possible, in accordance with Wolfe's Law. For cervical plating, in particular, a semi-rigid fixation may be advantageous. Devices of the disclosure accommodate this requirement by enabling a height adjustment postoperatively. This adjustability is provided by segments, or insert 300 and receiver 200, that telescope, or collapse and or expand in mutual connection, to a therapeutically effective height, thereby ensuring graft contact with the vertebral body endplates. By combining this dynamic aspect with a limiter 534, the amount of unloading of the graft may be limited, while preserving a dynamic height adjustment. Limiter 534 thus has at least two functions: helping to maintain receiver 200 and insert 300 in telescoping engagement, and providing a minimum amount of compression.
Reference may now be had to
A curved profile, indicated by arrow “B”, is formed by upper surfaces 548 of projections 536A. This curved profile corresponds to that of arch 648 of receiver 200, shown in
As insert 300 of device 100D is passed into receiver 300, engaging rails 332 and grooves 232, an initial catch 634A mates with projecting surfaces 536A, after which insert 300 and receiver are retained in mutual engagement by an engagement of steeply angled surface 550 and a mating surface of initial catch 634A. Engagement at this level may be used, for example, to maintain insert 300 and receiver 200 in mutual engagement, or to impose a minimum level of compression of body tissue as described elsewhere herein. Insert 300 may be urged further within receiver 200, as by use of a compression tool during surgery, or through carrying out sufficient range of motion of body tissue connected to device 100D. Movement of insert 300 further into receiver 200 causes projecting surfaces 634A to deflect limiter 534A, bending hinge 546, through interaction of ramped surface 552 (
In one embodiment, by first engaging initial catch 634A, an initial or minimum compression is applied to a bone graft. This minimum compression is maintained, while a dynamic range of motion imposing at least this minimum compression may subsequently be enabled by device 100D, when limiter groove 646 is engaged. Subsequent to enabling the dynamic range of motion, an excess unloading of the graft is ensured through engagement at a limit of limiter groove 646. In this manner, levels of tensile or extension movement are established which foster healing in accordance with Wolfe's Law.
It will be appreciated by persons skilled in the art that the present invention is not limited to what has been particularly shown and described herein above. In addition, unless mention was made above to the contrary, it should be noted that all of the accompanying drawings are not to scale. A variety of modifications and variations are possible in light of the above teachings without departing from the scope and spirit of the invention.
All references cited herein are expressly incorporated by reference in their entirety. In addition, unless mention was made above to the contrary, it should be noted that all of the accompanying drawings are not to scale. There are many different features to the present invention and it is contemplated that these features may be used together or separately. Thus, the invention should not be limited to any particular combination of features or to a particular application of the invention. Further, it should be understood that variations and modifications within the spirit and scope of the invention might occur to those skilled in the art to which the invention pertains. Accordingly, all expedient modifications readily attainable by one versed in the art from the disclosure set forth herein that are within the scope and spirit of the present invention are to be included as further embodiments of the present invention.
|Brevet cité||Date de dépôt||Date de publication||Déposant||Titre|
|US3604414 *||29 août 1968||14 sept. 1971||Nicomedes Borges||Bone setting device|
|US5616142 *||20 juil. 1994||1 avr. 1997||Yuan; Hansen A.||Vertebral auxiliary fixation device|
|US5672177 *||31 janv. 1996||30 sept. 1997||The General Hospital Corporation||Implantable bone distraction device|
|US5700263||17 juin 1996||23 déc. 1997||Schendel; Stephen A.||Bone distraction apparatus|
|US5827286||14 févr. 1997||27 oct. 1998||Incavo; Stephen J.||Incrementally adjustable tibial osteotomy fixation device and method|
|US6183476||25 juin 1999||6 févr. 2001||Orto Maquet Gmbh & Co. Kg||Plate arrangement for osteosynthesis|
|US6306136||27 juil. 1998||23 oct. 2001||Dimso (Distribution Medicales Du Sud-Ouest)||Implant, in particular front cervical plate|
|US6328738||24 nov. 1999||11 déc. 2001||Loubert Suddaby||Anterior cervical fusion compression plate and screw guide|
|US6645208||3 sept. 2002||11 nov. 2003||Aesculap Ag & Co. Kg||Osteosynthesis plating apparatus and method with extension plate|
|US6689134||7 mars 2002||10 févr. 2004||Third Millennium Engineering, Llc||Longitudinal plate assembly having an adjustable length|
|US6712818||17 juil. 2000||30 mars 2004||Gary K. Michelson||Method for connecting adjacent vertebral bodies of a human spine with a plating system|
|US6719759||6 sept. 2001||13 avr. 2004||Synthes Ag Chur||Bone plate|
|US6743255||15 mai 2002||1 juin 2004||Bret Ferree||Spinal fusion cage with lordosis correction|
|US6852113||14 déc. 2001||8 févr. 2005||Orthopaedic Designs, Llc||Internal osteotomy fixation device|
|US6932820 *||8 janv. 2002||23 août 2005||Said G. Osman||Uni-directional dynamic spinal fixation device|
|US7008427||25 mai 2001||7 mars 2006||Orthoplex, Llc||Inter-vertebral disc prosthesis for rachis through anterior surgery thereof|
|US7041105||4 juin 2002||9 mai 2006||Sdgi Holdings, Inc.||Dynamic, modular, multilock anterior cervical plate system having detachably fastened assembleable and moveable segments|
|US7044952||4 juin 2002||16 mai 2006||Sdgi Holdings, Inc.||Dynamic multilock anterior cervical plate system having non-detachably fastened and moveable segments|
|US7074221||24 sept. 2002||11 juil. 2006||Sdgi Holdings, Inc.||Anterior cervical plate system|
|US7097645||4 juin 2002||29 août 2006||Sdgi Holdings, Inc.||Dynamic single-lock anterior cervical plate system having non-detachably fastened and moveable segments|
|US7112202||27 mars 2004||26 sept. 2006||Warsaw Orthopedic, Inc.||Method for installing dynamic, modular, single-lock anterior cervical plate system having assembleable and moveable segments|
|US7115130||27 mars 2004||3 oct. 2006||Warsaw Orthopedic, Inc.||Method for installing dynamic, modular, multilock anterior cervical plate system having detachably fastened assembleable and moveable segments|
|US7118573||4 juin 2002||10 oct. 2006||Sdgi Holdings, Inc.||Dynamic anterior cervical plate system having moveable segments, instrumentation, and method for installation thereof|
|US7186254||4 févr. 2003||6 mars 2007||Dinh Dzung H||Methods and apparatus for promoting fusion of vertebrae|
|US7186256||4 juin 2002||6 mars 2007||Warsaw Orthopedic, Inc.||Dynamic, modular, single-lock anterior cervical plate system having assembleable and movable segments|
|US7214226||24 juil. 2003||8 mai 2007||Nas Spine, Inc.||Compressible fixation apparatus for spinal surgery|
|US7318825||22 déc. 2004||15 janv. 2008||Life Spine Llc||Dynamic cervical plates and cervical plate constructs|
|US7326212||19 nov. 2003||5 févr. 2008||Acumed Llc||Bone plates with reference marks|
|US7331961||10 janv. 2004||19 févr. 2008||Abdou M Samy||Plating system for bone fixation and subsidence and method of implantation|
|US7399301||25 mars 2004||15 juil. 2008||Warsaw Orthopedic, Inc.||Instrumentation for use with dynamic single-lock anterior cervical plate system having non-detachably fastened and moveable segments|
|US7419499||8 mars 2005||2 sept. 2008||Aesculap Inc.||Spinal stabilization implant and method of application|
|US7547306||17 mai 2005||16 juin 2009||Warsaw Orthopedic, Inc.||Method for installation of dynamic, single-lock anterior cervical plate system having non-detachably fastened and moveable segments|
|US7635364||1 déc. 2004||22 déc. 2009||Synthes Usa, Llc||Unidirectional translation system for bone fixation|
|US7635366||28 déc. 2004||22 déc. 2009||Abdou M Samy||Plating system for bone fixation and method of implantation|
|US7645295||24 juin 2005||12 janv. 2010||Said G. Osman||Method for postoperatively compressing a bone graft|
|US7727265||23 mai 2005||1 juin 2010||Paul Kamaljit S||Bone support plate assembly|
|US7763056||18 août 2003||27 juil. 2010||Dalton Brian E||Cervical compression plate assembly|
|US20030114856 *||14 déc. 2001||19 juin 2003||Nathanson Jeremy J.||Internal osteotomy fixation device|
|US20030187509||1 avr. 2003||2 oct. 2003||Lemole G. Michael||Modulus plating system and method|
|US20030229348||5 févr. 2003||11 déc. 2003||Sevrain Lionel C.||Auxiliary vertebrae connecting device|
|US20040006343||2 juin 2003||8 janv. 2004||Sevrain Lionel C.||Auxiliary vertebrae connecting device|
|US20040019353||23 janv. 2003||29 janv. 2004||Freid James M.||Spinal plate system for stabilizing a portion of a spine|
|US20040092939||24 janv. 2003||13 mai 2004||Freid James M.||Spinal plate system for stabilizing a portion of a spine|
|US20040181229 *||25 mars 2004||16 sept. 2004||Michelson Gary K.||Instrumentation for use with dynamic single-lock anterior cervical plate system having non-detachably fastened and moveable segments|
|US20040204712||17 sept. 2003||14 oct. 2004||Eric Kolb||Bone fixation plates|
|US20050010227||12 sept. 2003||13 janv. 2005||Paul Kamaljit S.||Bone support plate assembly|
|US20050049595||2 sept. 2004||3 mars 2005||Suh Sean S.||Track-plate carriage system|
|US20050149026||21 déc. 2004||7 juil. 2005||Life Spine||Static & dynamic cervical plates and cervical plate constructs|
|US20060116683||1 déc. 2004||1 juin 2006||Barrall Benjamin S||Unidirectional translation system for bone fixation|
|US20060200134||19 sept. 2005||7 sept. 2006||James Freid||Spinal plate system for stabilizing a portion of a spine|
|US20060235405||30 mars 2006||19 oct. 2006||Hawkes David T||Active compression orthopedic plate system and method for using the same|
|US20060271052||3 mai 2006||30 nov. 2006||Stern Joseph D||Revisable anterior cervical plating system|
|US20060276794||14 juin 2006||7 déc. 2006||Stern Joseph D||Revisable anterior cervical plating system|
|US20070213729||8 mars 2006||13 sept. 2007||Sdgi Holdings, Inc.||Flexible bone plates and methods for dynamic spinal stabilization|
|US20070270855||6 avr. 2007||22 nov. 2007||Lotus Medical, Llc||Active compression to facilitate healing of bones|
|US20070288010||13 avr. 2007||13 déc. 2007||Nas Spine, Inc.||Compressible fixation apparatus for spinal surgery|
|US20080065070||20 avr. 2007||13 mars 2008||Freid James M||Spinal plate system for stabilizing a portion of a spine|
|US20080097445||22 oct. 2007||24 avr. 2008||Weinstein Robert B||Bone fixation system|
|US20080108998||2 nov. 2006||8 mai 2008||Warsaw Orthopedic Inc.||Uni-directional ratcheting bone plate assembly|
|US20080114361||11 janv. 2008||15 mai 2008||Life Spine Llc||Dynamic cervical plates and cervical plate constructs|
|US20080154312||12 déc. 2007||26 juin 2008||Dennis Colleran||Active settling plate with elastomeric members and method of use|
|US20080177263||24 oct. 2006||24 juil. 2008||Aesculap Implant Systems, Inc||Dynamic stabilization device for anterior lower lumbar vertebral fusion|
|US20080195100||8 févr. 2007||14 août 2008||Warsaw Orthopedic, Inc.||Adjustable coupling systems for spinal stabilization members|
|US20080215097||19 mars 2008||4 sept. 2008||Ensign Michael D||Active Compression Orthopedic Plate System and Method for Using the Same|
|US20080234680||25 janv. 2008||25 sept. 2008||Structure Medical, Inc.||Interlock for dynamic bone fixation plates|
|US20080243191||17 avr. 2008||2 oct. 2008||Fx Devices, Llc||Adjustable bone plate fixation system and metho|
|US20080269753||24 avr. 2008||30 oct. 2008||Blue Fury Consulting, Llc||Dynamic cervical plate|
|US20090076509||13 sept. 2007||19 mars 2009||Stryker Spine||Dynamic cervical plate|
|US20090082813||26 sept. 2007||26 mars 2009||Depuy Products, Inc.||Modular bone plate system|
|US20090138054 *||31 oct. 2008||28 mai 2009||Michael Teague||Bi-dicrectionally expandable sternal clamp device|
|US20090259226||16 juin 2009||15 oct. 2009||Michelson Gary K||Method for installation of dynamic, single-lock anterior cervical plate system having non-detachably fastened and moveable segments|
|US20090264934||22 avr. 2008||22 oct. 2009||Youssef Jim A||Bone plate system configurable as static or dynamic implant|
|US20090275947||2 mai 2008||5 nov. 2009||Thomas James Graham||Bone plate system for bone restoration and methods of use thereof|
|US20100057127 *||26 août 2009||4 mars 2010||Mcguire Brian||Expandable Laminoplasty Fixation System|
|US20100063505||22 mars 2007||11 mars 2010||Robert Frigg||Bone plate|
|US20100076495||25 nov. 2009||25 mars 2010||Lindemann Gary S||Flexible bone plates and methods for dynamic spinal stabilization|
|US20100082029||20 mars 2007||1 avr. 2010||Ib Medical, Llc||Static Compression Device|
|US20100114176||26 janv. 2010||6 mai 2010||Ibrahim Zaki G||Static Compression Device|
|US20100121329||20 janv. 2010||13 mai 2010||Ryan Christopher J||Translatable carriage fixation system|
|US20100137909||7 déc. 2009||3 juin 2010||Osman Said G||Method for postoperatively compressing a bone graft|
|US20100211108||23 avr. 2010||19 août 2010||Lanx, Inc.||Modulus plating system and method|
|US20100234888||23 avr. 2010||16 sept. 2010||K2M, Inc.||Dynamic cervical plate|
|Classification internationale||A61B17/70, A61B17/80|
|Classification coopérative||A61B17/8009, A61B17/8004, A61B17/7059, A61B17/8023|
|25 juin 2015||AS||Assignment|
Owner name: GLOBUS MEDICAL, INC., PENNSYLVANIA
Free format text: ASSIGNMENT OF ASSIGNORS INTEREST;ASSIGNORS:ANGELUCCI, CHRISTOPHER;BLACK, MICHAEL;GARVEY, BRIAN;AND OTHERS;SIGNING DATES FROM 20110615 TO 20110628;REEL/FRAME:035966/0014