WO1981000207A1 - Pharmaceutical preparation - Google Patents
Pharmaceutical preparation Download PDFInfo
- Publication number
- WO1981000207A1 WO1981000207A1 PCT/AU1980/000029 AU8000029W WO8100207A1 WO 1981000207 A1 WO1981000207 A1 WO 1981000207A1 AU 8000029 W AU8000029 W AU 8000029W WO 8100207 A1 WO8100207 A1 WO 8100207A1
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- preparation
- antiseptic
- epidermis
- disinfecting
- absorbed
- Prior art date
Links
- 239000000825 pharmaceutical preparation Substances 0.000 title description 4
- ZCYVEMRRCGMTRW-UHFFFAOYSA-N 7553-56-2 Chemical compound [I] ZCYVEMRRCGMTRW-UHFFFAOYSA-N 0.000 claims abstract description 11
- 229910052740 iodine Inorganic materials 0.000 claims abstract description 11
- 239000011630 iodine Substances 0.000 claims abstract description 11
- 210000002615 epidermis Anatomy 0.000 claims abstract description 8
- 210000003491 skin Anatomy 0.000 claims abstract description 8
- 239000003795 chemical substances by application Substances 0.000 claims abstract description 4
- 239000000203 mixture Substances 0.000 claims abstract 3
- 238000002360 preparation method Methods 0.000 claims description 11
- 230000002421 anti-septic effect Effects 0.000 claims description 5
- 108010003272 Hyaluronate lyase Proteins 0.000 claims description 4
- 102000001974 Hyaluronidases Human genes 0.000 claims description 4
- 229960002773 hyaluronidase Drugs 0.000 claims description 4
- 229920001499 Heparinoid Polymers 0.000 claims description 3
- 229940116830 organo-heparinoid Drugs 0.000 claims description 3
- 230000000249 desinfective effect Effects 0.000 claims 3
- 239000004599 antimicrobial Substances 0.000 claims 1
- 238000011109 contamination Methods 0.000 claims 1
- 210000004207 dermis Anatomy 0.000 claims 1
- 239000000645 desinfectant Substances 0.000 claims 1
- 239000002270 dispersing agent Substances 0.000 claims 1
- 230000000694 effects Effects 0.000 claims 1
- 238000009472 formulation Methods 0.000 claims 1
- 244000005700 microbiome Species 0.000 claims 1
- 230000002035 prolonged effect Effects 0.000 claims 1
- 210000001519 tissue Anatomy 0.000 claims 1
- 230000000699 topical effect Effects 0.000 abstract description 4
- 238000010521 absorption reaction Methods 0.000 abstract description 3
- 230000001737 promoting effect Effects 0.000 abstract description 3
- 238000009877 rendering Methods 0.000 abstract 1
- 208000015181 infectious disease Diseases 0.000 description 5
- 241000894006 Bacteria Species 0.000 description 2
- 241000700605 Viruses Species 0.000 description 2
- 239000007864 aqueous solution Substances 0.000 description 2
- 239000002855 microbicide agent Substances 0.000 description 2
- 230000035515 penetration Effects 0.000 description 2
- 239000000243 solution Substances 0.000 description 2
- CPKVUHPKYQGHMW-UHFFFAOYSA-N 1-ethenylpyrrolidin-2-one;molecular iodine Chemical compound II.C=CN1CCCC1=O CPKVUHPKYQGHMW-UHFFFAOYSA-N 0.000 description 1
- 102000004190 Enzymes Human genes 0.000 description 1
- 108090000790 Enzymes Proteins 0.000 description 1
- 241000233866 Fungi Species 0.000 description 1
- 229920000153 Povidone-iodine Polymers 0.000 description 1
- 240000004808 Saccharomyces cerevisiae Species 0.000 description 1
- 239000002253 acid Substances 0.000 description 1
- 239000013543 active substance Substances 0.000 description 1
- 230000000844 anti-bacterial effect Effects 0.000 description 1
- 239000003443 antiviral agent Substances 0.000 description 1
- 239000003899 bactericide agent Substances 0.000 description 1
- 239000003153 chemical reaction reagent Substances 0.000 description 1
- 210000002808 connective tissue Anatomy 0.000 description 1
- 239000006071 cream Substances 0.000 description 1
- 229940088598 enzyme Drugs 0.000 description 1
- 150000002148 esters Chemical class 0.000 description 1
- 239000000417 fungicide Substances 0.000 description 1
- 239000008269 hand cream Substances 0.000 description 1
- 230000009931 harmful effect Effects 0.000 description 1
- 230000002458 infectious effect Effects 0.000 description 1
- 230000001524 infective effect Effects 0.000 description 1
- 230000000977 initiatory effect Effects 0.000 description 1
- PNDPGZBMCMUPRI-UHFFFAOYSA-N iodine Chemical compound II PNDPGZBMCMUPRI-UHFFFAOYSA-N 0.000 description 1
- 239000000463 material Substances 0.000 description 1
- 206010027175 memory impairment Diseases 0.000 description 1
- 238000000034 method Methods 0.000 description 1
- 230000003641 microbiacidal effect Effects 0.000 description 1
- 229940124561 microbicide Drugs 0.000 description 1
- 230000000474 nursing effect Effects 0.000 description 1
- 235000013855 polyvinylpyrrolidone Nutrition 0.000 description 1
- 229920000036 polyvinylpyrrolidone Polymers 0.000 description 1
- 239000001267 polyvinylpyrrolidone Substances 0.000 description 1
- 229960001621 povidone-iodine Drugs 0.000 description 1
- 230000000630 rising effect Effects 0.000 description 1
- 238000010186 staining Methods 0.000 description 1
- 239000004094 surface-active agent Substances 0.000 description 1
- 239000000725 suspension Substances 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K33/00—Medicinal preparations containing inorganic active ingredients
- A61K33/18—Iodine; Compounds thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/43—Enzymes; Proenzymes; Derivatives thereof
- A61K38/46—Hydrolases (3)
- A61K38/47—Hydrolases (3) acting on glycosyl compounds (3.2), e.g. cellulases, lactases
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/46—Ingredients of undetermined constitution or reaction products thereof, e.g. skin, bone, milk, cotton fibre, eggshell, oxgall or plant extracts
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
- A61K47/58—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. poly[meth]acrylate, polyacrylamide, polystyrene, polyvinylpyrrolidone, polyvinylalcohol or polystyrene sulfonic acid resin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0014—Skin, i.e. galenical aspects of topical compositions
Definitions
- This invention concerns pharmaceu tical preparations for topical application to the skin in order to render the skin surface aseptic.
- Bacteria and viruses are frequently tra nsm itted by one person to another by skin contact and especially by the transfer of facteria on the skin of the palms and fingers. This is an ever present risk in hospitals where doctors and nursing staff shoul d continually cleanse their hands when dealing with patients. However this frequent ly does not occur, whether for reasons of forgetfulness or pressure of time, and therefore the risk of transferring infection remains.
- a preparation is therefore required which combines a microbicidal agent with the convenienve of lonh-actinh surface action, thereby affording the minimum number of applications over a period of time in order to overcome the human problems associated with the spresd of infection in this manner. It has been shown that mere surface cleansing of the epidermis is effective only for a short period because living organisms which inhabit the epidermal interstices are constantly rising to the surface thereof. Thus any surface application of surface active agents, bactericide s, fungicides and anti-viral drugs can only exert temporary action before necessary cleansing removes them.
- This invention seeks to provide preparation for topical application wherein the presence of the active agents in the epidermis will be more difficult to dispel.
- This invention provides a pharmaceutical preparation for topical application to the skin comprising a germicidally effective quantity of iodine. in a combined form and an agent for promoting the absorption and dispersal of the latter in the epidermis.
- the iodine is elemental iodine in polyvinylpyrrolidone.
- Sim ilarly polymeric suspensions of iodine are expected to be e qually effective.
- This component of the preparation may be present as a 10-15% aqueous solution.
- the reagent for promoting dispersal of the iodine and its absorption may be hyaluronidase or an organo -heparinoid. A quantity of lower than 7% of this enzyme suffices to give satisfactory penetrati on of the iodine.
- An example of an organoheparinoid is a mucopolysaccaride polysulphuric acid ester.
- a small quantity of a 0.5% solution of hyaluronidase is added to a 21 ⁇ 2% aqueous solution of Povidone-Iodine (Registered Trade Mark) which is a commonly available, form of iodine combined with polyninylpyrrolidone.
- Povidone-Iodine Registered Trade Mark
- This solution is dispersed in a standard hand cream fo rmulation, that is of the vanishing type.
- the action of the cream softens the horny l ayer of the epidermis while the hyaluronidase promotes the penetration of the iodine , dissolving to a small extent the connective tissue which is directly beneath the horny layer.
- This preparation therefore permits the use of element Iodine as a microbicide without harmful effects on the user, while the efficacy of its action is improved by its penetration below the skin's surface, both in terms of effec tiveness over time and by virtue of its action against sub-epithelial microbes.
- This preparation caters for this problem by providing a method of perhaps once a day application of an antiseptic known to be effective against bacteria in general, funguses, yeasts, protozoa, viruses and veget ative organisms.
- an antiseptic known to be effective against bacteria in general, funguses, yeasts, protozoa, viruses and veget ative organisms.
- the minimisation of the number of times a preparation of this type is requrired to be applied, will cater for the failure to cleanse hands for any reason, and therefore reduce transfer of infection in this manner.
Abstract
A topical composition for rendering the skin aseptic, consisting of a combined form of iodine and an agent for promoting the absorption and dispersal of the composition in the epidermis.
Description
This invention concerns pharmaceu tical preparations for topical application to the skin in order to render the skin surface aseptic.
Bacteria and viruses are frequently tra nsm itted by one person to another by skin contact and especially by the transfer of facteria on the skin of the palms and fingers. This is an ever present risk in hospitals where doctors and nursing staff shoul d continually cleanse their hands when dealing with patients. However this frequent ly does not occur, whether for reasons of forgetfulness or pressure of time, and therefore the risk of transferring infection remains.
A preparation is therefore required which combines a microbicidal agent with the convenienve of lonh-actinh surface action, thereby affording the minimum number of applications over a period of time in order to overcome the human problems associated with the spresd of infection in this manner. It has been shown that mere surface cleansing of the epidermis is effective only for a short period because living organisms which inhabit the epidermal interstices are constantly rising to the surface thereof. Thus any surface application of surface active agents, bactericide s, fungicides and anti-viral drugs can only exert temporary action before necessary cleansing removes them. This invention seeks to provide preparation for topical application wherein the presence of the active agents in the epidermis will be more difficult to dispel.
"PHARMACEUTICAL PREPARATION"
The Invention is described in the following statement:-
This invention provides a pharmaceutical preparation for topical application to the skin comprising a germicidally effective quantity of iodine. in a combined form and an agent for promoting the absorption and dispersal of the latter in the epidermis.
Preferably the iodine is elemental iodine in polyvinylpyrrolidone. Sim ilarly polymeric suspensions of iodine are expected to be e qually effective. This component of the preparation may be present as a 10-15% aqueous solution. The reagent for promoting dispersal of the iodine and its absorption may be hyaluronidase or an organo -heparinoid. A quantity of lower than 7% of this enzyme suffices to give satisfactory penetrati on of the iodine. An example of an organoheparinoid is a mucopolysaccaride polysulphuric acid ester. In addition there may be an agent to re duce the stai ning tendency of the iodine.
In one example of the invention a small quantity of a 0.5% solution of hyaluronidase is added to a 2½% aqueous solution of Povidone-Iodine (Registered Trade Mark) which is a commonly available, form of iodine combined with polyninylpyrrolidone.
This solution is dispersed in a standard hand cream fo rmulation, that is of the vanishing type. The action of the cream softens the horny l ayer of the epidermis while the hyaluronidase promotes the penetration of the iodine , dissolving to a small extent the connective tissue which is directly beneath the horny layer.
This preparation therefore permits the use of element Iodine as a microbicide without harmful effects on the user, while the efficacy of its action is improved by its penetration below the skin's surface, both in terms of effec tiveness over time and by virtue of its action against sub-epithelial microbes.
Because of the failure of personnel dealing with infectious or infective material and environments to satisfac torily cleanse their hands, the problem of initiation and transfer of infection exists. This preparation caters for this problem by providing a method of perhaps once a day application of an antiseptic known to be effective against bacteria in general, funguses, yeasts, protozoa, viruses and veget ative organisms. The minimisation of the number of times a preparation of this type is requrired to be applied, will cater for the failure to cleanse hands for any reason, and therefore reduce transfer of infection in this manner.
Claims
(1) Because of its formulation, namely the combination of the polyuinllpyrrolidone form of elemental iodine and a tissue dispersant agent, hyaluronidase or an organo-heparinoid, the preparation will be absorbed into the epidermis, a function not performed by any other avail able antiseptic or disinfecting preparation.
(2) Because it is absorbed into the epidermis the antiseptic and disinfecting action of the preparation is in effect prolonged over a period of time not presently possible by any other antiseptic or disinfecting agent.
(3) Because it is absorbed into the epidermis and possibly (to a lesser extent) into the dermis, the preparation will act against resident micro-organisms, which would otherwise rise tothe surface of the skin, thereby causing re-contamination. This sub-epithelial antiseptic and/or disinfecting action is not possible with presently available preparations.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
AU9543/79 | 1979-07-11 | ||
AU954379 | 1979-07-11 |
Publications (1)
Publication Number | Publication Date |
---|---|
WO1981000207A1 true WO1981000207A1 (en) | 1981-02-05 |
Family
ID=3700291
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/AU1980/000029 WO1981000207A1 (en) | 1979-07-11 | 1980-07-03 | Pharmaceutical preparation |
Country Status (2)
Country | Link |
---|---|
EP (1) | EP0031827A1 (en) |
WO (1) | WO1981000207A1 (en) |
Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0338589A2 (en) * | 1988-04-22 | 1989-10-25 | Fred Leroy Stoner | Microbicidal cleanser/barrier kit for preventing the transmission of aids and other sexually transmitted diseases |
US4996146A (en) * | 1987-02-20 | 1991-02-26 | Kessler Jack H | Rapid sterilization enzymatic process with persistence |
Citations (20)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US2550622A (en) * | 1947-07-11 | 1951-04-24 | Benjamin Clayton | Ointment base and iodine ointment |
US2739922A (en) * | 1952-03-13 | 1956-03-27 | Herman A Shelanski | Mixtures of polymeric n-vinyl pyrrolidone and halogens |
US2776924A (en) * | 1954-02-05 | 1957-01-08 | Coty Inc | Composition of matter containing polyvinylpyrrolidone and a fatty carrier |
AU2077256A (en) * | 1956-08-15 | 1957-02-21 | General Aniline & Film Corporation | Improvements in iodine complexes of copolymers of n-vinyl-2-pyrrolidones and nitrogen free vinyl and vinylidene compounds |
US2976212A (en) * | 1956-12-01 | 1961-03-21 | Schenley Ind Inc | Hyaluronidase with heparin or heparinoids in ointment compositions |
US3152951A (en) * | 1960-11-18 | 1964-10-13 | Perlman Samuel Donald | Germicidal composition of iodine and liquid lanolin |
US3210248A (en) * | 1963-09-04 | 1965-10-05 | Merck & Co Inc | Emollient gel comprising lanolin alcohol, microcrystalline wax and a liqquid fatty acid ester |
US3472931A (en) * | 1969-01-17 | 1969-10-14 | Foster Milburn Co | Percutaneous absorption with lower alkyl amides |
US3728449A (en) * | 1972-05-01 | 1973-04-17 | West Laboratories Inc | Germicidal iodine compositions for application to skin tissue including teats of milk animals |
US3751562A (en) * | 1972-09-22 | 1973-08-07 | Princeton Biomedix | Medicated gelled oils |
FR2201881A1 (en) * | 1972-06-28 | 1974-05-03 | Manoil Jean | Antiseptic creams for cows udders - contg. fat and halogen, protects against bacteria, weather and skin lesions and improves skin suppleness |
GB1441364A (en) * | 1974-02-19 | 1976-06-30 | Diversey Ltd | Iodophor compositions |
CH582001A5 (en) * | 1971-08-06 | 1976-11-30 | Mundipharma Ag | Solid iodine-contg germicidal detergents |
US4012504A (en) * | 1972-05-12 | 1977-03-15 | Velvet Chemical Co. | Iodine mineral oil solution for preventing bovine mastitis |
FR2323393A1 (en) * | 1975-09-12 | 1977-04-08 | West Laboratories Inc | Germicidal gels contg. iodine - in which the gelling agent is a block copolymer of ethylene and propylene oxides |
US4017408A (en) * | 1975-07-14 | 1977-04-12 | Fults Elmer H | Water soluble liquid iodine concentrate, aqueous iodine bacteriocidal solution and methods of making the same |
DE2611701A1 (en) * | 1976-03-18 | 1977-09-29 | Josef Dipl Chem Dr Rer N Klosa | Polyvinyl pyrrolidone and iodine adduct - used in deodorising space and cosmetic compsns. |
CA1028242A (en) * | 1975-02-20 | 1978-03-21 | Diversey (Canada) Ltd. | Iodophor compositions |
GB1516653A (en) * | 1974-08-09 | 1978-07-05 | West Laboratories Inc | Poloxamer-iodine gel |
AU552439B2 (en) * | 1981-12-14 | 1986-05-29 | Lockheed Missiles & Space Company, Inc. | Single stage high pressure centrifugal slurry pump |
-
1980
- 1980-07-03 WO PCT/AU1980/000029 patent/WO1981000207A1/en unknown
-
1981
- 1981-02-09 EP EP80901260A patent/EP0031827A1/en not_active Withdrawn
Patent Citations (21)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US2550622A (en) * | 1947-07-11 | 1951-04-24 | Benjamin Clayton | Ointment base and iodine ointment |
US2739922A (en) * | 1952-03-13 | 1956-03-27 | Herman A Shelanski | Mixtures of polymeric n-vinyl pyrrolidone and halogens |
US2776924A (en) * | 1954-02-05 | 1957-01-08 | Coty Inc | Composition of matter containing polyvinylpyrrolidone and a fatty carrier |
AU2077256A (en) * | 1956-08-15 | 1957-02-21 | General Aniline & Film Corporation | Improvements in iodine complexes of copolymers of n-vinyl-2-pyrrolidones and nitrogen free vinyl and vinylidene compounds |
US2976212A (en) * | 1956-12-01 | 1961-03-21 | Schenley Ind Inc | Hyaluronidase with heparin or heparinoids in ointment compositions |
US3152951A (en) * | 1960-11-18 | 1964-10-13 | Perlman Samuel Donald | Germicidal composition of iodine and liquid lanolin |
US3210248A (en) * | 1963-09-04 | 1965-10-05 | Merck & Co Inc | Emollient gel comprising lanolin alcohol, microcrystalline wax and a liqquid fatty acid ester |
AU4939464A (en) * | 1964-09-17 | 1966-03-17 | Samuel Donald Perlman | Germicidal composition |
US3472931A (en) * | 1969-01-17 | 1969-10-14 | Foster Milburn Co | Percutaneous absorption with lower alkyl amides |
CH582001A5 (en) * | 1971-08-06 | 1976-11-30 | Mundipharma Ag | Solid iodine-contg germicidal detergents |
US3728449A (en) * | 1972-05-01 | 1973-04-17 | West Laboratories Inc | Germicidal iodine compositions for application to skin tissue including teats of milk animals |
US4012504A (en) * | 1972-05-12 | 1977-03-15 | Velvet Chemical Co. | Iodine mineral oil solution for preventing bovine mastitis |
FR2201881A1 (en) * | 1972-06-28 | 1974-05-03 | Manoil Jean | Antiseptic creams for cows udders - contg. fat and halogen, protects against bacteria, weather and skin lesions and improves skin suppleness |
US3751562A (en) * | 1972-09-22 | 1973-08-07 | Princeton Biomedix | Medicated gelled oils |
GB1441364A (en) * | 1974-02-19 | 1976-06-30 | Diversey Ltd | Iodophor compositions |
GB1516653A (en) * | 1974-08-09 | 1978-07-05 | West Laboratories Inc | Poloxamer-iodine gel |
CA1028242A (en) * | 1975-02-20 | 1978-03-21 | Diversey (Canada) Ltd. | Iodophor compositions |
US4017408A (en) * | 1975-07-14 | 1977-04-12 | Fults Elmer H | Water soluble liquid iodine concentrate, aqueous iodine bacteriocidal solution and methods of making the same |
FR2323393A1 (en) * | 1975-09-12 | 1977-04-08 | West Laboratories Inc | Germicidal gels contg. iodine - in which the gelling agent is a block copolymer of ethylene and propylene oxides |
DE2611701A1 (en) * | 1976-03-18 | 1977-09-29 | Josef Dipl Chem Dr Rer N Klosa | Polyvinyl pyrrolidone and iodine adduct - used in deodorising space and cosmetic compsns. |
AU552439B2 (en) * | 1981-12-14 | 1986-05-29 | Lockheed Missiles & Space Company, Inc. | Single stage high pressure centrifugal slurry pump |
Non-Patent Citations (3)
Title |
---|
Acta Dermatovzer (Stockholm), Supplement 73, issued 1973, TATSUYA OHKUBO and SHIGEHARU SANO, "Functional Aspects of Dermo-Epidermal Junction", pages 121 - 128. * |
K. Meyer and M.M. Rapport, 'Advances in Enzymology' (Editor: F.F. Nord), Volume XIII, published 1952, by Interscience Publishers Inc. (New York), see pages 224 - 226. * |
The American Journal of Surgery, Volume 132, issued 1976, July, G. Rodeheaver, V. Turnbull, M.T. Edgerton, L. Kurtz and R.F. Edlich, "Pharmacokinetics of New Skin Wound Cleanser", pages 67 - 74. * |
Cited By (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4996146A (en) * | 1987-02-20 | 1991-02-26 | Kessler Jack H | Rapid sterilization enzymatic process with persistence |
EP0338589A2 (en) * | 1988-04-22 | 1989-10-25 | Fred Leroy Stoner | Microbicidal cleanser/barrier kit for preventing the transmission of aids and other sexually transmitted diseases |
EP0338589A3 (en) * | 1988-04-22 | 1990-11-28 | Fred Leroy Stoner | Microbicidal cleanser/barrier kit for preventing the transmission of aids and other sexually transmitted diseases |
Also Published As
Publication number | Publication date |
---|---|
EP0031827A1 (en) | 1981-07-15 |
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