WO1985003217A1 - Apparatus for perforating the front wall of the phacocyst of the eye of a living being - Google Patents

Apparatus for perforating the front wall of the phacocyst of the eye of a living being Download PDF

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Publication number
WO1985003217A1
WO1985003217A1 PCT/DE1984/000024 DE8400024W WO8503217A1 WO 1985003217 A1 WO1985003217 A1 WO 1985003217A1 DE 8400024 W DE8400024 W DE 8400024W WO 8503217 A1 WO8503217 A1 WO 8503217A1
Authority
WO
WIPO (PCT)
Prior art keywords
wire
tube
drive motor
eye
front wall
Prior art date
Application number
PCT/DE1984/000024
Other languages
German (de)
French (fr)
Inventor
Hans-Joachim Schlegel
Original Assignee
Schlegel Hans Joachim
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Schlegel Hans Joachim filed Critical Schlegel Hans Joachim
Priority to JP59501012A priority Critical patent/JPS61501067A/en
Priority to EP84900967A priority patent/EP0170650B1/en
Priority to US06/783,934 priority patent/US4706669A/en
Priority to PCT/DE1984/000024 priority patent/WO1985003217A1/en
Publication of WO1985003217A1 publication Critical patent/WO1985003217A1/en

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61FFILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F9/00Methods or devices for treatment of the eyes; Devices for putting-in contact lenses; Devices to correct squinting; Apparatus to guide the blind; Protective devices for the eyes, carried on the body or in the hand
    • A61F9/007Methods or devices for eye surgery
    • A61F9/013Instruments for compensation of ocular refraction ; Instruments for use in cornea removal, for reshaping or performing incisions in the cornea
    • A61F9/0133Knives or scalpels specially adapted therefor
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61FFILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F9/00Methods or devices for treatment of the eyes; Devices for putting-in contact lenses; Devices to correct squinting; Apparatus to guide the blind; Protective devices for the eyes, carried on the body or in the hand
    • A61F9/007Methods or devices for eye surgery
    • A61F9/00736Instruments for removal of intra-ocular material or intra-ocular injection, e.g. cataract instruments
    • A61F9/00754Instruments for removal of intra-ocular material or intra-ocular injection, e.g. cataract instruments for cutting or perforating the anterior lens capsule, e.g. capsulotomes

Definitions

  • the invention relates to a ; Device for perforating the front wall of the lens capsule in the eye of living beings for the purpose of removing a portion of the wall of the capsule and producing an opening in it through which the contents of the lens capsule can be removed, 5
  • the invention has for its object to provide a suitable for the mentioned purpose, structurally simple and reliable working, always ready for use, which makes it possible to open the lens capsule quickly and reliably in the desired, optimal manner, so that a hole is obtained in the front wall, which is located where it is desired and which is defined in terms of its size and shape.
  • the hydrostatic pressure in the anterior chamber of the eye should continue to be maintained during the use of this device in order to be able to work in an optimal operating field.
  • the drawing shows a longitudinal section through the device designed according to the invention.
  • This consists of a handpiece 11, on the " front part 12 of which a tube .13 is coaxially fastened.
  • the front end 14 of the tube 13 is pressed somewhat flat and provided with a curvature 15.
  • T3 is an axially oscillating movable wire 16 with a relatively large amount of play, which is bent at its front end 17 in a wave shape and is provided with a tip 18.
  • the wire 16 is with. his rear. End connected to a shaft or piston 19, which projects with its front end 20 into the chamber 21 in the handpiece 11, which is sealed towards the rear against the piston 21 by means of sealing sleeves 22.
  • a connection piece 23 arranged on the handpiece and into which a hose can be plugged opens into the chamber 21, in order to convey liquid under a predetermined pressure into the chamber 21, which then during use of the device passes through the wire guide tube 13 and at its front End emerges in order to maintain a certain hydrostatic pressure in the opened front chamber of the eye to be operated on, which considerably facilitates or favors the operation in the opened eye,
  • the lens capsule front wall is perforated along a line determined by the surgeon, usually a circle, the punctures being close together. This is achieved in that the wire 16 is moved back and forth at a certain frequency, for example of about 30-80 Hz.
  • An electromagnet as well as an electric motor can be used as the drive unit, provided that the movement characteristic is such that the tip 18 of the oscillating wire 16 can safely penetrate the capsule wall during its propulsion.
  • the axial movements of the wire 16 should not follow a sine function, since its tip 18 has the lowest speed and acceleration values at the movement reversal points. Since the lens capsule consists of an extraordinarily tough and resistant tissue, in order to achieve good work results, the wire tip 18 has to be prematurely rushed in order to suddenly pierce the lens capsule wall.
  • a drive unit which consists of a drive motor with a rotating rotor
  • an electric motor 25 in a housing 24, the hollow shaft 26 of which rotates a drive ring 28 provided with a cam track 27 in rotation.

Abstract

Apparatus for perforating the front wall of the phacocyst of the eye of a living being in order to remove part of the capsula wall and to make an opening enabling to take out the contents of the phacocyst. On a hand piece (11) there is provided a small tube (13) wherein is guided a wire (16) provided at its free end with a point (18), the wire being connected to a drive motor for the displacement thereof with axial reciprocating motions.

Description

Gerät zum Perforieren der Linsenkapselvorderwand im Auge von Lebewesen Device for perforating the lens capsule front wall in the eye of living beings
Die Erfindung betrifft ein; Gerät zum Perforieren der Linsenkap¬ selvorderwand im Auge von Lebewesen zwecks Entfernens eines Teilstücks der Kapselwand und Herstellung einer Öffnung in die¬ ser, durch welche hindurch der Linsenkapselinhalt entfernbar ist, 5The invention relates to a ; Device for perforating the front wall of the lens capsule in the eye of living beings for the purpose of removing a portion of the wall of the capsule and producing an opening in it through which the contents of the lens capsule can be removed, 5
Es war bisher üblich, den Linsenkapselsack mittels ver¬ schiedenster Instrumente zu eröffnen, wobei jedoch in aller Regel der Rand der in die Vorderwand des Linsenkörpersacks geschnittenen Öffnung eine mehr oder weniger unregelmäßig 0 gezackte oder ausgefranste Form aufweist. Dies ist jedoch ungünstig, speziell im Hinblick auf operative Maßnahmen, um dem Patienten eine Implantatlinse einzusetzen.It was previously customary to open the lens capsule bag using a wide variety of instruments, but as a rule the edge of the opening cut into the front wall of the lens body bag has a more or less irregularly jagged or frayed shape. However, this is disadvantageous, especially with regard to surgical measures, in order to insert an implant lens for the patient.
Es besteht schon seit langem der Wunsch, über ein Gerät ver- S fügen zu können, welches in der Lage ist, aus der Vorderwand des Linsenkapselsacks eine kreisrunde Scheibe bestimmter Größe auszuschneiden, um eine kreisrunde Öffnung mit glattem, ungezacktem Rand längs der Schnittlinie zu erhalten. Geräte, die dies ermöglichen, sind bisher nicht bekanntgeworden, weshalb der Erfindung die Aufgabe zugrundeliegt, ein solches Gerät zu schaffen, welches die vorstehend aufgezeigte Aufgabe zu erfüllen vermag.There has long been a desire to be able to have a device which is able to cut a circular disk of a certain size from the front wall of the lens capsule bag in order to obtain a circular opening with a smooth, jagged edge along the cutting line . Devices which make this possible have hitherto not become known, which is why the invention is based on the object of creating such a device which is capable of fulfilling the object shown above.
Zur Lösung dieser Aufgabe wurdevorgeschlagen, das in Betracht kommende Gerät in der Weise auszubilden, daß sich an bzw. in einem in das eröffnete Auge einführbaren Schneidkopf eine ringförmige Führungsbahn befindet, entlang welcher ein diese in axialer Richtung überragendes, bei seiner Bewegung einen Kreisschnitt ausführendes Schneidmesser geführt ist.To solve this problem, it was proposed to design the device in question in such a way that there is an annular guideway on or in a cutting head that can be inserted into the open eye, along which a cutting knife that projects in the axial direction and performs a circular cut when moving is led.
OMPIOMPI
Ersaizb'att Das vorerwähnte Gerät erfüllt zwar seine Aufgabe in durchaus zufriedenstellender Weise, jedoch ist es durch seinen mechani¬ schen Aufbau bedingt, außerordentlich empfindlich und damit störanfällig. Daher ist es als ein bei den in Betracht kommen- den Operationen einzusetzendes Gerät ungeeignet.Ersaizb'att The above-mentioned device does its job quite satisfactorily, but due to its mechanical structure it is extremely sensitive and therefore prone to failure. Therefore, it is unsuitable as a device to be used in the operations under consideration.
Der Erfindung liegt die Aufgabe zugrunde, ein für den erwähn¬ ten Zweck geeignetes, konstruktiv einfaches und zuverlässig arbeitendes, stets einsatzbereits Gerät zu schaffen, welches es-ermöglicht, die Linsenkapsel rasch und zuverlässig in ge¬ wünschter, optimaler Weise zu eröffnen, so daß ein Loch in der Vorderwand erhalten wird, das sich an der Stelle befindet, an der es gewünscht wird, und welches hinsichtlich seiner Größe und Form definiert ist. Dabei soll weiterhin während des Ein- satzes dieses Geräts der hydrostatische Druck in der Vorder¬ kammer des Auges aufrechterhalten bleiben, um in einem opti¬ malen Operationsfeld arbeiten zu können.The invention has for its object to provide a suitable for the mentioned purpose, structurally simple and reliable working, always ready for use, which makes it possible to open the lens capsule quickly and reliably in the desired, optimal manner, so that a hole is obtained in the front wall, which is located where it is desired and which is defined in terms of its size and shape. The hydrostatic pressure in the anterior chamber of the eye should continue to be maintained during the use of this device in order to be able to work in an optimal operating field.
Zur Lösung dieser Aufgabe wird gemäß der Erfindung vorgeschla- gen, das in Betracht kommende Gerät in der Weise auszubilden, wie dies insbesondere im Patentanspruch 1 und weiterhin in den Unteransprüchen angegeben ist, sowie in Bezug auf ein bevorzugtes Ausführungsbeispiel beschrieben und dargestellt ist.To achieve this object, it is proposed according to the invention to design the device in question in the manner as specified in particular in claim 1 and also in the subclaims, as well as described and illustrated in relation to a preferred exemplary embodiment.
Die Zeichnung zeigt einen Längsschnitt durch das erfindungs¬ gemäß ausgebildete Gerät. Dieses besteht aus einem Handstück 11, an dessen" vorderen Teil 12 ein Röhrchen .13 koaxial befestigt ist. Das vordere Ende 14 des Röhrchens 13 ist etwas flach ge- drückt und mit einer Krümmung 15 versehen. In dem Röhrchen"T3 ist ein axial oszillierend bewegbarer Draht 16 mit relativ viel Spiel gelagert, der an seinem vorderen Ende 17 wellenför¬ mig gebogen und mit einer Spitze 18 versehen ist.The drawing shows a longitudinal section through the device designed according to the invention. This consists of a handpiece 11, on the " front part 12 of which a tube .13 is coaxially fastened. The front end 14 of the tube 13 is pressed somewhat flat and provided with a curvature 15. In the tube " T3 is an axially oscillating movable wire 16 with a relatively large amount of play, which is bent at its front end 17 in a wave shape and is provided with a tip 18.
Ersatzblatt Der Draht 16 ist mit. seinem hinteren. Ende mit einem Schaft bzw. Kolben 19 verbunden, der mit seinem vorderen Ende 20 in die Kammer 21 im Handstück 11 hineinragt, die nach hinten gegen den Kolben 21 mittels Dichtungsmanschetten 22 abgedichtet ist. In die Kammer 21 mündet ein am Handstück angeordneter Anschlu߬ stutzen 23 , auf den ein Schlauch aufsteckbar ist, um unter vorbestimmtem Druck stehende Flüssigkeit in die Kammer 21 zu fördern, die dann während der Benutzung des Geräts durch das Drahtführungsröhrchen 13 hindurch und an dessen vorderen Ende austritt, um einen bestimmten hydrostatischen Druck in der er¬ öffneten Vorderkammer des zu operierenden Auges aufrechtzuer¬ halten, was die Operation im eröffneten Auge erheblich erleich¬ tert bzw. begünstigt,Spare sheet The wire 16 is with. his rear. End connected to a shaft or piston 19, which projects with its front end 20 into the chamber 21 in the handpiece 11, which is sealed towards the rear against the piston 21 by means of sealing sleeves 22. A connection piece 23 arranged on the handpiece and into which a hose can be plugged opens into the chamber 21, in order to convey liquid under a predetermined pressure into the chamber 21, which then during use of the device passes through the wire guide tube 13 and at its front End emerges in order to maintain a certain hydrostatic pressure in the opened front chamber of the eye to be operated on, which considerably facilitates or favors the operation in the opened eye,
Mit der Spitze 18 am vorderen Ende des Drahtes 16 wird die Lin¬ senkapselvorderwand entlang einer vom Operateur bestimmten Linie, zumeist eines Kreises, perforiert, wobei die Einstiche dicht bei dicht nebeneinander liegen. Dies wird dadurch erreicht, daß der Draht 16 mit einer bestimmten Frequenz, beispielsweise von etwa 30-80 Hz, hin- und herbewegt wird. Als Antriebsaggregat kann so¬ wohl ein Elektromagnet, als auch ein Elektromotor Anwendung fin¬ den, vorausgesetzt, daß die Bewegungscharakteristik eine solche ist, daß die Spitze 18 des oszillierenden Drahtes 16 bei ihrem Vortrieb sicher die Kapselwand zu durchdringen vermag. Die axia- len Bewegungen des Drahtes 16 sollen nicht einer Sinusfunktion folgen, da dessen Spitze 18 an den Bewegungsumkehrpunkten die geringsten Geschwindigkeits- und Beschleunigungswerte aufweist. Da die Linsenkapsel aus einem außerordentlich zähen und wider¬ standsfähigen Gewebe besteht, muß, um gute Arbeitsergebnisse zu erzielen, die Drahtspitze 18 sehr spontan vorgeschnellt werden, um so die Linsenkapselwand schlagartig zu durchstoßen.With the tip 18 at the front end of the wire 16, the lens capsule front wall is perforated along a line determined by the surgeon, usually a circle, the punctures being close together. This is achieved in that the wire 16 is moved back and forth at a certain frequency, for example of about 30-80 Hz. An electromagnet as well as an electric motor can be used as the drive unit, provided that the movement characteristic is such that the tip 18 of the oscillating wire 16 can safely penetrate the capsule wall during its propulsion. The axial movements of the wire 16 should not follow a sine function, since its tip 18 has the lowest speed and acceleration values at the movement reversal points. Since the lens capsule consists of an extraordinarily tough and resistant tissue, in order to achieve good work results, the wire tip 18 has to be prematurely rushed in order to suddenly pierce the lens capsule wall.
Um dies zu erreichen, findet vorzugsweise ein Antriebsaggregat Anwendung, welches aus einem Antriebsmotor mit umlaufendem RotorTo achieve this, a drive unit is preferably used, which consists of a drive motor with a rotating rotor
* RiXtr- * RiXtr-
OMPI und einer relativ einfachen Mechanik besteht, die den Kolben 21 und damit den Draht 16 zurückzieht und dabei gleichzeitig eine diese beaufschlagende Feder spannt, die bei ihrer plötz¬ lichen Entspannung den Draht 16 in gewünschter Weise vor- 5 schnellen läßt.OMPI and there is a relatively simple mechanism which retracts the piston 21 and thus the wire 16 and at the same time tensions a spring which acts on it and which, when suddenly released, allows the wire 16 to advance in the desired manner.
Am hinteren Ende des Handstücks 11 befindet sich in einem Ge¬ häuse 24 ein Elektromotor 25, dessen Hohlwelle 26 einen mit einer Kurvenbahn 27 versehenen Antriebsring 28 in Drehung ver-At the rear end of the handpiece 11 there is an electric motor 25 in a housing 24, the hollow shaft 26 of which rotates a drive ring 28 provided with a cam track 27 in rotation.
1Q setzt. An diesem liegt die mit dem Antriebsschaft 29 verbunde¬ ne, gleichfalls mit einer korrespondierenden Kurvenbahn 30 ver¬ sehene Antriebsscheibe 31 an, die bei einer Drehung des Antriebs¬ ringes 28 axial zurückbewegt wird, wobei sie den Antriebsschaft 29 zurückzieht. An diesem befindet sich ein Federteller 32,1Q sets. The drive disk 31 connected to the drive shaft 29 and also provided with a corresponding cam track 30 bears against this, which is axially moved back when the drive ring 28 rotates, pulling the drive shaft 29 back. There is a spring plate 32 on this,
T5 durch den die Feder 33 gespannt wird. Bei entsprechender Lage des Antriebsrings 28 gegenüber der Antriebsscheibe 31 löst sich letztere von dem Antriebsring 28, sodaß dann die Feder 33 den Antriebsschaft 29 schlagartig nach vorn treiben kann.T5 by which the spring 33 is tensioned. With a corresponding position of the drive ring 28 relative to the drive disk 31, the latter disengages from the drive ring 28, so that the spring 33 can then suddenly drive the drive shaft 29 forward.
ERSATZBLATT REPLACEMENT LEAF

Claims

A n s p r ü c h e Expectations
1. Gerät zum Perforieren der Linsenkapselvorderwand im Auge von Lebewesen zwecks Entfernens eines Teilstücks der Kapselwand und Herstellung einer Öffnung, durch welche hindurch der Linsenkapselinhalt entfernbar ist, gekenn¬ zeichnet durch ein an einem Handstück angeordnetes Röhr¬ chen, in welchem ein an seinem freien Ende mit einer Spitze versehener Draht geführt ist, welcher mit einem diesen in axial hin- und hergehende Bewegungen versetzen¬ den Antriebsmotor verbunden ist.1. Device for perforating the lens capsule front wall in the eye of living beings for the purpose of removing a portion of the capsule wall and producing an opening through which the lens capsule contents can be removed, characterized by a tube arranged on a handpiece, in which a tube at its free end is provided with a tip wire which is connected to a drive motor which sets them in axially back and forth movements.
2. Gerät nach Anspruch 1, dadurch gekennzeichnet, daß die lichte Weite des Röhrchens mindestens etwa doppelt so groß ist wie der Durchmesser des Drahtes.2. Apparatus according to claim 1, characterized in that the inside width of the tube is at least about twice as large as the diameter of the wire.
3. Gerät nach Anspruch 1 oder 2, dadurch gekennzeichnet, daß das Röhrchen im Bereich seiner Mündung einen ovalen Quer¬ schnitt aufweist.3. Apparatus according to claim 1 or 2, characterized in that the tube has an oval cross-section in the region of its mouth.
4. Gerät nach Anspruch 1, 2 oder 3, dadurch gekennzeichnet, daß der. Draht an seinem vorderen freien Ende gegen seine Spitze hin" in einer Radialebene zunächst nach der einen Seite und dann nach der anderen, entgegengesetzten Seite gekrümmt ist.4. Apparatus according to claim 1, 2 or 3, characterized in that the. Wire is curved at its front free end towards its tip " in a radial plane first to one side and then to the other, opposite side.
OMH 5. Gerät nach einem oder mehreren der Ansprüche 1 bis 4, dadurch gekennzeichnet, daß in das den Draht führende Röhrchen bzw. in das mit diesem verbundene Anschlu߬ stück ein Stutzen zum Anschluß einer Flüssigkeits- zuführleitung einmündet.OMH 5. Apparatus according to one or more of claims 1 to 4, characterized in that in the tube leading the wire or in the connecting piece connected to it a nozzle opens for connecting a liquid supply line.
Gerät nach einem oder mehreren der Ansprüche 1 bis 5, dadurch gekennzeichnet, daß der Inπeπraum im Draht- führungsröhrchen bzw. in dessen Anschlußstück- gegen denjenigen im Handstück abgedichtet und'ein mit dem Draht verbundener Kolben od.dgl. durch die Dichtung hindurchgeführt ist.Device according to one or more of claims 1 to 5, characterized in that the ferrule in Inπeπraum wire or sealed in its Anschlußstück- against those in the handpiece and 'a service associated with the wire or the like piston. is passed through the seal.
7. Gerät nach Anspruch 6, dadurch gekennzeichnet, daß als Dichtung wenigstens eine Maπschettendichtung mit Dich¬ tungslippe vorgesehen ist.7. Apparatus according to claim 6, characterized in that at least one sleeve seal with sealing lip is provided as the seal.
8. Gerät nach einem oder mehreren der Ansprüche 1 bis 7, dadurch gekennzeichnet, daß als Antriebsmotor des mit dem Draht verbundenen Kolbens ein Elektromagnet dient.8. Device according to one or more of claims 1 to 7, characterized in that an electromagnet serves as the drive motor of the piston connected to the wire.
9. Gerät nach einem oder mehreren der Ansprüche 1 bis 7, dadurch gekennzeichnet, daß als Antriebsmotor ein Elektromotor dient, welcher mittels eines mechanischen Getriebes periodisch eine auf den mit dem Draht ver¬ bundenen Kolben wirkende Feder spannt und diese dann plötzlich wieder entspannt.9. Device according to one or more of claims 1 to 7, characterized in that an electric motor is used as the drive motor, which periodically tensions a spring acting on the piston connected to the wire by means of a mechanical gear and then suddenly relaxes again.
10. Gerät nach einem oder mehreren der Ansprüche 1 bis 7, dadurch gekennzeichnet, daß als Aπtriebsmotor ein pneumatischer oder hydraulischer Zylinder dient, welcher periodisch eine auf den mit dem Draht verbundenen Kolben wirkende Feder spannt und diese dann plötzlich wieder entspannt.10. Apparatus according to one or more of claims 1 to 7, characterized in that a pneumatic or hydraulic cylinder is used as the drive motor, which periodically tensions a spring acting on the piston connected to the wire and then suddenly relaxes again.
i l0 i l0
PCT/DE1984/000024 1984-01-30 1984-01-30 Apparatus for perforating the front wall of the phacocyst of the eye of a living being WO1985003217A1 (en)

Priority Applications (4)

Application Number Priority Date Filing Date Title
JP59501012A JPS61501067A (en) 1984-01-30 1984-01-30 Living eye lens capsule anterior wall drilling device
EP84900967A EP0170650B1 (en) 1984-01-30 1984-01-30 Apparatus for perforating the front wall of the phacocyst of the eye of a living being
US06/783,934 US4706669A (en) 1984-01-30 1984-01-30 Device for perforating the lens capsule front wall in the eye of living beings
PCT/DE1984/000024 WO1985003217A1 (en) 1984-01-30 1984-01-30 Apparatus for perforating the front wall of the phacocyst of the eye of a living being

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PCT/DE1984/000024 WO1985003217A1 (en) 1984-01-30 1984-01-30 Apparatus for perforating the front wall of the phacocyst of the eye of a living being

Publications (1)

Publication Number Publication Date
WO1985003217A1 true WO1985003217A1 (en) 1985-08-01

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PCT/DE1984/000024 WO1985003217A1 (en) 1984-01-30 1984-01-30 Apparatus for perforating the front wall of the phacocyst of the eye of a living being

Country Status (4)

Country Link
US (1) US4706669A (en)
EP (1) EP0170650B1 (en)
JP (1) JPS61501067A (en)
WO (1) WO1985003217A1 (en)

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US4706669A (en) 1987-11-17
EP0170650A1 (en) 1986-02-12
JPS61501067A (en) 1986-05-29
EP0170650B1 (en) 1988-05-04

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