WO1989007419A1 - Sonde d'imagerie ultrasonore - Google Patents

Sonde d'imagerie ultrasonore Download PDF

Info

Publication number
WO1989007419A1
WO1989007419A1 PCT/US1989/000017 US8900017W WO8907419A1 WO 1989007419 A1 WO1989007419 A1 WO 1989007419A1 US 8900017 W US8900017 W US 8900017W WO 8907419 A1 WO8907419 A1 WO 8907419A1
Authority
WO
WIPO (PCT)
Prior art keywords
probe
transducer
holder
ultrasonic imaging
imaging probe
Prior art date
Application number
PCT/US1989/000017
Other languages
English (en)
Inventor
Joseph L. Pope, Jr.
James M. Griffith
James M. Gessert
Mario Maciel
Paul J. Zalesky
Original Assignee
Inter-Therapy, Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Inter-Therapy, Inc. filed Critical Inter-Therapy, Inc.
Priority to DE68926415T priority Critical patent/DE68926415T2/de
Priority to EP89901769A priority patent/EP0356473B1/fr
Publication of WO1989007419A1 publication Critical patent/WO1989007419A1/fr
Priority to DK507389A priority patent/DK507389A/da

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B8/00—Diagnosis using ultrasonic, sonic or infrasonic waves
    • A61B8/06—Measuring blood flow
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B8/00—Diagnosis using ultrasonic, sonic or infrasonic waves
    • A61B8/12—Diagnosis using ultrasonic, sonic or infrasonic waves in body cavities or body tracts, e.g. by using catheters
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B8/00—Diagnosis using ultrasonic, sonic or infrasonic waves
    • A61B8/44—Constructional features of the ultrasonic, sonic or infrasonic diagnostic device
    • A61B8/4444—Constructional features of the ultrasonic, sonic or infrasonic diagnostic device related to the probe
    • A61B8/445—Details of catheter construction
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B8/00—Diagnosis using ultrasonic, sonic or infrasonic waves
    • A61B8/44—Constructional features of the ultrasonic, sonic or infrasonic diagnostic device
    • A61B8/4444—Constructional features of the ultrasonic, sonic or infrasonic diagnostic device related to the probe
    • A61B8/4461—Features of the scanning mechanism, e.g. for moving the transducer within the housing of the probe

Definitions

  • This invention generally relates to ultrasonic intravascular imaging devices — i.e., devices of the type which utilize acoustic transducers operating at ultrasonic frequencies to image intravascular geometry and/or associated tissue characteristics.
  • it includes an elongate probe guide assembly, an ultrasonic transducer fixed to the probe guide assembly's distal end, and electrical cabling housed within, and extending proximally of, the probe guide assembly so as to send/receive electrical signals to/from the transducer.
  • This invention effectively reduces "dead space” radially of the probe otherwise obscuring nearby reflections during the normal "ring down" time of a piezoelectric transceiver/transducer immediately after a transmit operation.
  • a reflector is distally spaced from the transducer so as to reflect the ultrasound waves between a first path which is substantially parallel to the probe axis and a second path which is substantially perpendicular (i.e., radial) to the probe axis.
  • a tuning induction coil is electrically connected in series with the transducer and is coaxially positioned within the tube section closely adjacent to the transducer. Such structure permits the ultrasound probes of this invention to be sufficiently miniaturized to be useful in extremely near-field intravascular imaging procedures.
  • Intravascular probes which include ultrasound imaging crystal arrays have been proposed in the past. It is known, for example, to mount a piezoelectric crystal element (conventionally termed a "transducer") on or within a catheter of the type which can be inserted into a blood vessel. Once the probe has been inserted into a blood vessel, the transducer is electro-mechanically excited (as by the application of an electrical signal) to cause emission of ultrasonic energy into the surrounding tissue.
  • a piezoelectric crystal element conventionally termed a "transducer”
  • the transducer is electro-mechanically excited (as by the application of an electrical signal) to cause emission of ultrasonic energy into the surrounding tissue.
  • the transducer in turn, produces weak electrical signals in response to electro mechanical excitation by the returning reflected ("echo") ultrasonic energy.
  • These weak electrical signals can be used to determine the geometry and/or other characteristics of the blood vessel, for example, to determine whether or not the blood vessel contains lesions or other abnormalities.
  • imaging suitable video and/or other signal monitoring equipment are employed to convert the weak electrical signals produced by the transducer into human-readable form. Information gained from such imaging thus may assist the physician in a vascular treatment in real time or in diagnosing a patient's particular ailment or disease so that suitable therapy can be prescribed.
  • ring down time will inherently be present so that a region surrounding the transducer is effectively masked -- that is to say, the ring down time creates a "dead space" in the immediate vicinity of the transducer where no imaging is possible.
  • transducer dead space The dimensional extent of such dead space is dependant upon many variables, including the frequency of operation of the transducer. Suffice it to say here that although transducer dead space can be tolerated when relatively large intravascular cavities are imaged (i.e., relative to the size of the imaging probe), significant problems are encountered when small intravascular cavities, such as small diameter blood vessels, etcetera, are to be imaged. And, in any event, transducer dead space mitigates against miniaturization since even the smallest diameter imaging probe is only capable of imaging intravascular cavities outside of its surrounding dead space, thereby providing for an effective imaging area which is usually only significantly greater than the probe's diameter.
  • transducer must be "tuned” to the electrical cabling which supplies driving signals to, and returns weaker echo electrical signals from, the transducer. That is, since the transducer, at its frequency of operation, exhibits a net capacitive reactance, inductive reactance should be provided so as to efficiently couple the transmit/receive signals to the transducer (e.g., so as to maximize signal-to-noise ratios) .
  • the present invention provides a miniaturized ultrasonic imaging probe which not only exhibits essentially zero "dead space" (i.e., intravascular imaging can be accomplished in blood vessels having, or capable of being dilated to, substantially the same diameter as the probe itself) but also provides for internal (i.e., as part of the probe per se) inductive reactance. And, the fact that internal inductive reactance may now be provided enhances the ability to use weak electrical echo signals for purposes of diagnostic imaging.
  • an ultrasonic imaging probe of the type including a probe guide assembly, a transducer connected to the distal end of the probe guide assembly, and electrical cabling housed within the probe guide assembly and operatively connected to the transducer for transmitting electrical power to, and receiving electrical signals from, the transducer.
  • the transducer is mounted within a proximal end portion of a generally cylindrical holder (itself being attached to the distal end of the probe guide assembly) which defines an elongate, open trough.
  • the transducer is also mounted near the proximal end of the trough.
  • An ultrasound reflector (e.g., polished stainless steel) is mounted at the distal end of the holder (i.e., at the distal end of the defined trough) in axially spaced relation to the transducer for directing ultrasonic energy waves between a first path (which is substantially parallel to the elongate axis of the probe) to a second path (which is substantially perpendicular to the elongate axis of the probe).
  • a first path which is substantially parallel to the elongate axis of the probe
  • second path which is substantially perpendicular to the elongate axis of the probe.
  • Echo waves which radially return from the surrounding tissue will likewise be redirected by means of the reflector axially of the probe towards the transducer.
  • the distance that the reflector is axially spaced from the transducer is selected such that the "dead space" lies substantially therebetween.
  • the probe of the invention is also provided with an inductor coil as the inductive reactance, the inductor coil being coaxially housed within the probe guide assembly and positioned closely adjacent the transducer.
  • the electrical cabling of the invention is a standard coaxial cable having an inner conductor (with an associated insulating layer) and an annular outer conductor (with an associated insulating layer) .
  • a distal end segment of the outer conductor (and its associated insulating layer) is removed.
  • the inductor coil is then coaxially positioned over the inner conductor (and its associated insulating layer) in the space previously occupied by the removed outer conductor segment.
  • the proximal end of the inductor coil is thus connected to the distal end of the remaining outer conductor while the distal end of the inductor coil is connected electrically to the transducer.
  • the inner conductor is connected electrically to the transducer at a location different from the connection of the inductor coil (preferably at a location on the front face of the transducer) . In such a manner, the transducer and inductor coil are connected closely adjacent, and in series relationship, to one another.
  • FIGURE 1 is a schematic diagram of an exemplary ultrasound imaging system with which the ultrasound imaging probe of this invention is used;
  • FIGURE 2 is a perspective view, partly in section, of the ultrasound imaging probe of this invention.
  • FIGURE 3 is an axial cross-sectional view of the imaging probe shown in FIGURE 2 taken along line 3-3 therein.
  • System 10 generally includes an ultrasound imaging probe 12 (which will be described in greater detail below) generally comprised of proximal probe guide assembly 14, an ultrasound "bullet” 16 (i.e., structure which includes the ultrasound transducer), and a distal guidewire assembly 18.
  • a visual position indicator and rotation knob 20 are operatively associated with the probe 12 so as to assist the physician in his/her intravascular manipulation and positioning of the bullet 16.
  • An ultrasound transmitter/receiver 24 is connected to a preamplifier 26 via standard coaxial cable 28.
  • the transmitter/receiver 24 is of a conventional type in that it produces a pulse signal (of a desired magnitude and shape) which is applied via cable 28 and preamplifier 26 to excite an electroacoustic transducer housed within bullet 16.
  • the receiver portion of transmitter/receiver 24 performs conventional signal processing operations (e.g., amplification, noise reduction and the like) on electrical signals generated by electro mechanical excitation of the transducer within bullet 16 (i.e., signals generated by the transducer in response to receiving echo waves), which signals have been amplified via preamplifier 26.
  • These processed signals are then supplied as an input to a CRT 20 monitor (or any other equivalent display device) so as to generate an ultrasound image 30 representative of the vascular structures reflecting ultrasonic energy toward the transducer within bullet 16 using, for example, conventional PPI (radar) algorithms.
  • a CRT 20 monitor or any other equivalent display device
  • the imaging probe 12 of this invention is shown more clearly in accompanying FIGURES 2 and 3 in a greatly enlarged manner for clarity of presentation.
  • the probe 12 can be of any desired length, it preferably is fabricated to a length of about 60 inches having a nominal diameter of about .0038 inch.
  • the probe guide assembly 14 is currently comprised of a coaxial cable 28 housed within the lumen 32 (see FIGURE 3) of a tube section 33 so as to transmit electrical pulses to, and return electrical signals from, the transducer 34 housed within the bullet 16.
  • the bullet 16 is itself comprised of a one-piece holder 36 which defines an axially elongate open trough 38.
  • the holder 36 thus houses the transducer 34 within its proximal end so that the front face 40 of transducer 34 extends slightly beyond the proximal end 42 of trough 38.
  • the other, distal end of holder 36 houses an acoustic reflector 44 (whose functions will be described in greater detail below) which in the preferred embodiment shown, defines a beveled planar surface 46 oriented at an angle (e.g., 45°) relative to the longitudinal axis 48 of probe 12.
  • the surface 46 of reflector 44 may, however, be concave, particularly if convergent focussing of emitted/returned echo waves is desired. In either case, the angular orientation of surface 46 with respect to a transverse plane may be greater/lesser than 45° so as to project the reflected acoustic waves in a proximal/distal direction, respectively.
  • the acoustic reflector 44 and holder 36 are each preferably fabricated from stainless steel and are rigidly coupled to one another via soldering, welding or like techniques.
  • the transducer 34 is rigidly maintained within holder 36 via a suitable biocompatible adhesive.
  • transducer 34 and reflector 44 within holder 36 could, however, be reversed from that shown in the accompanying FIGURES, if desired.
  • transducer 34 could occupy the distal end of holder 36 while reflector 44 could occupy the proximal end of holder 36.
  • the open trough 38 is filled with a solid acoustic couplant 49 which is shown only in FIGURE 3 for clarity of presentation.
  • Acoustic couplant 49 can be any suitable minimally acoustic-absorbant polymer material such as low density polyethlene, polyurethane, and the like.
  • Couplant 49 thus exhibits an acoustic impedence which is closely matched to that of transducer 34 and the patient's blood.
  • the acoustic couplant 49 also presents an overall smooth cylindrical exterior surface to holder 36 which is beneficial since the holder 36 may then be more easily manipulated within a patient's arterial tissue. Because it fills the trough 38, the acousic couplant 49 prevents blood from pooling and clotting within holder 36, which clotting could cause patient thrombosis.
  • the distal guidewire assembly 18 is comprised of a coiled guidewire 50 (e.g., formed from about .003 in. diameter wire and tightly coiled to an outside diameter of about .038 in.) having its proximal end 50a rigidly coupled to the holder/reflector 36/44 as by soldering, welding or the like.
  • a tip 52 of a noble metal e.g., gold, platinum or the like
  • Tip 52 presents a smooth convex surface to more easily facilitate intravascular maneuvering. Also, since the tip 52 is formed of a noble metal, it is visible when fluoroscopic techniques are employed.
  • the tip 52 also embeds the distal end of a continuous safety ribbon 54.
  • the proximate end of ribbon 54 is soldered or welded rigidly to an axially bevelled surface 56 of a generally cylindrical, distally extending boss 58 integral with reflector 44.
  • the ribbon 54 thus provides an added measure of safety to ensure that the assembly 18 will not inadvertently become separated from the catheter 12 during use.
  • the proximal end of holder 36 is rigidly connected to the distal end of tube section 33 via a "trumpet-shaped" connecting region 60. That is, the tube section 33 includes an outwardly (i.e., in the distal direction) flared region 62 coupled to the interior of an inwardly (i.e., in a proximal direction) tapered region 64 of the holder 36. The region 64 thus surrounds and is rigidly coupled (as by soldering, welding, or the like) to the region 62 so as to prevent separation of the holder 36 and tube section 33 during intravascular manipulations.
  • the tube section 33 is formed of stainless steel and dimensioned so as to be about six (6) inches in length and have about a .028 in. outside diameter and about a .023 in. inside diameter.
  • the tube section 33 is thin-walled (e.g., about .0025 in. thick) such that it is flexible (bendable) relative to the catheter axis 48.
  • the tube section 33 is surrounded by another coiled guide wire 66 and extends proximally beyond the axial length of tube section 33 (i.e., to the exterior of the patient so as to permit guide wire 66 functions to support tube 33 (i.e., so as to provide increased strength) so as to prevent kinks from forming in the otherwise thin-walled tube 33 when it is manipulated during intravascular imaging.
  • the guide wire 66 is formed of a tightly coiled wire approximately .005 in. in diameter so that the resulting inside diameter of the coil is about .0028 inch.
  • the coaxial cable 28 is of a conventional type in that it includes a center conductor 70 (and its associated insulating layer 72) and an annular (i.e., braided shield) outer conductor 74 (and its associated outer insulating layer 76).
  • the inner and outer conductors are preferably copper, but other electrically conductive materials may be employed provided that the impedance of the cable is sufficient for purposes of ultrasound imaging.
  • the coaxial cable 28, in the preferred embodiment will exhibit an impedance of about 25 or 50 ohms.
  • a distal segment 78 (see FIGURE 3) of the outer conductor/insulating layer 74/76 is removed according to this invention and, in its place, an inductor coil 80 is positioned coaxially surrounding the underlying inner conductor/insulating layer 70/72.
  • the proximal end of inductor coil 80 is electrically connected to the terminal end of the outer conductor 76 while the other distal end of inductor coil 80 is electrically connected via a soldered flat copper ribbon 81 (about .01 in. wide by .001 in. thick) to the peripheral exterior surface of transducer 34 (or at any other suitable location) .
  • the terminal end of the center conductor 70 is electrically coupled via a soldered flat copper ribbon 82 (similar to ribbon 81), to the front face 40 of transducer 34 (i.e., at a location different from that of the electrical connection of ribbon 81, and hence coil 80).
  • the inductor coil 80 is therefore series-connected to the transducer 34.
  • coil 80 The particular characteristics.of coil 80 are chosen so as to "tune" the signal carrying capability of cable 28 to the operating characteristics of the transducer 34. That is, the wire diameter, coil size, number of turns, etcetera, are selected so that the overall performance of the inductor coil 80 is such that it exhibits an inductive reactance which is substantially equivalent to the net capacitive reactance of the transducer 34 at its operating frequency.
  • coil 80 will be formed of about .005 in. diameter single strand, ML (DuPontTM) coated copper wire and coiled to an outside diameter of about .020 in. and a length of about 2.8 inches.
  • the probe 12 is intravascularly inserted into a patient.
  • the catheter 12 may conveniently be inserted percutaneously into the patient's femoral artery.
  • the catheter 12 is then maneuvered by the physician until a desired region of the patient's coronary arteries is adjacent the bullet 16, such maneuvering being aided by the position indicator and rotation knob 20 (see FIGURE 1) in addition to the fluoroscopically visible tip 52 (i.e., if fluoroscopic imaging techniques are also employed) .
  • ultrasound imaging of the adjacent arterial tissue may be accomplished conventionally by sending electrical pulses to and receiving electrical signals from, transducer 34 as has been previously described.
  • the transmission of ultrasound waves to/from transducer 34 may be aided by the presence of blood and/or other body fluids in trough 38, which fluids serve to acoustically couple the transducer 34 and reflector 44.
  • the "dead space" i.e., that region in advance of the transducer 34 in which no imaging is possible

Abstract

Une sonde intravasculaire miniature d'imagerie ultrasonore (12) comprend une unité de guidage de sonde (14), à laquelle est fixé un transducteur ultrasonore (34), et un câblage électrique (28) logé à l'intérieur et connecté de façon opérationnelle au transducteur (34) de façon à envoyer des signaux/impulsions électriques à destination/en provenance du transducteur (34). Le transducteur (34) émet/reçoit des ondes ultrasonores le long d'un chemin parallèle à l'axe longitudinal de la sonde (12). Les ondes ultrasonores sont dirigées radialement par rapport à la sonde (12) au moyen d'un élément à réflecteur (44) qui est éloigné distalement du transducteur (34) le long de l'axe de la sonde par un écart dont la dimension est suffisante pour éliminer ''l'espace mort'' (c'est-à-dire une zone dans laquelle l'imagerie ultrasonore n'est pas possible) radialement par rapport à la sonde (12). Une bobine inductrice (80) (qui syntonise le transducteur avec le câblage électrique) est logée coaxialement dans l'unité de guidage de sonde (14) à proximité adjacente du transducteur, auquel elle est connectée en série.
PCT/US1989/000017 1988-02-22 1989-01-04 Sonde d'imagerie ultrasonore WO1989007419A1 (fr)

Priority Applications (3)

Application Number Priority Date Filing Date Title
DE68926415T DE68926415T2 (de) 1988-02-22 1989-01-04 Ultraschall bildsonde
EP89901769A EP0356473B1 (fr) 1988-02-22 1989-01-04 Sonde d'imagerie ultrasonore
DK507389A DK507389A (da) 1988-02-22 1989-10-12 Sonde til billeddannelse ved hjaelp af ultralyd

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US07/158,761 US4899757A (en) 1988-02-22 1988-02-22 Ultrasound imaging probe with zero dead space
US158,761 1988-02-22

Publications (1)

Publication Number Publication Date
WO1989007419A1 true WO1989007419A1 (fr) 1989-08-24

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ID=22569592

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US1989/000017 WO1989007419A1 (fr) 1988-02-22 1989-01-04 Sonde d'imagerie ultrasonore

Country Status (8)

Country Link
US (1) US4899757A (fr)
EP (3) EP0356473B1 (fr)
JP (1) JP2766696B2 (fr)
AT (2) ATE137649T1 (fr)
AU (2) AU611256B2 (fr)
DE (2) DE68926415T2 (fr)
DK (1) DK507389A (fr)
WO (1) WO1989007419A1 (fr)

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EP0646349A3 (fr) 1995-04-19
EP0356473A4 (en) 1991-01-23
AU6761490A (en) 1991-03-14
EP0646349A2 (fr) 1995-04-05
EP0356473A1 (fr) 1990-03-07
DE68928882D1 (de) 1999-01-28
US4899757A (en) 1990-02-13
AU2938689A (en) 1989-09-06
EP0356473B1 (fr) 1996-05-08
JP2766696B2 (ja) 1998-06-18
EP0646349B1 (fr) 1998-12-16
AU643734B2 (en) 1993-11-25
EP0646348A3 (fr) 1995-04-19
EP0646348A2 (fr) 1995-04-05
DE68928882T2 (de) 1999-07-22
JPH02503279A (ja) 1990-10-11
ATE137649T1 (de) 1996-05-15
AU611256B2 (en) 1991-06-06
DE68926415T2 (de) 1996-11-28
DK507389D0 (da) 1989-10-12
ATE174490T1 (de) 1999-01-15
DE68926415D1 (de) 1996-06-13
DK507389A (da) 1989-10-12

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