WO1990002579A2 - Catheter introducer with flexible tip - Google Patents
Catheter introducer with flexible tip Download PDFInfo
- Publication number
- WO1990002579A2 WO1990002579A2 PCT/US1989/003266 US8903266W WO9002579A2 WO 1990002579 A2 WO1990002579 A2 WO 1990002579A2 US 8903266 W US8903266 W US 8903266W WO 9002579 A2 WO9002579 A2 WO 9002579A2
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- catheter
- introducer
- body portion
- copolymer
- catheter introducer
- Prior art date
Links
- 238000003780 insertion Methods 0.000 claims abstract description 28
- 230000037431 insertion Effects 0.000 claims abstract description 28
- 239000000017 hydrogel Substances 0.000 claims abstract description 16
- 239000011248 coating agent Substances 0.000 claims abstract description 14
- 238000000576 coating method Methods 0.000 claims abstract description 14
- 210000004204 blood vessel Anatomy 0.000 claims description 29
- 229920001577 copolymer Polymers 0.000 claims description 20
- 229920000571 Nylon 11 Polymers 0.000 claims description 14
- 239000004952 Polyamide Substances 0.000 claims description 13
- 229920002647 polyamide Polymers 0.000 claims description 13
- 229920002635 polyurethane Polymers 0.000 claims description 8
- 239000004814 polyurethane Substances 0.000 claims description 8
- 150000002148 esters Chemical class 0.000 claims description 7
- 229920000036 polyvinylpyrrolidone Polymers 0.000 claims description 6
- 235000013855 polyvinylpyrrolidone Nutrition 0.000 claims description 6
- 239000001267 polyvinylpyrrolidone Substances 0.000 claims description 6
- 239000004677 Nylon Substances 0.000 claims description 4
- 229920001778 nylon Polymers 0.000 claims description 4
- 239000002861 polymer material Substances 0.000 claims description 4
- 238000007789 sealing Methods 0.000 claims description 3
- 238000009877 rendering Methods 0.000 claims description 2
- 229920002614 Polyether block amide Polymers 0.000 description 19
- 239000000203 mixture Substances 0.000 description 14
- 239000000463 material Substances 0.000 description 11
- -1 polytetrafluoroethylene Polymers 0.000 description 10
- 239000004698 Polyethylene Substances 0.000 description 5
- 239000012530 fluid Substances 0.000 description 4
- 208000014674 injury Diseases 0.000 description 4
- 229920000573 polyethylene Polymers 0.000 description 4
- 230000008733 trauma Effects 0.000 description 3
- 239000004721 Polyphenylene oxide Substances 0.000 description 2
- 239000004743 Polypropylene Substances 0.000 description 2
- 239000004793 Polystyrene Substances 0.000 description 2
- 208000027418 Wounds and injury Diseases 0.000 description 2
- 238000005299 abrasion Methods 0.000 description 2
- 238000005452 bending Methods 0.000 description 2
- 238000011010 flushing procedure Methods 0.000 description 2
- 239000007788 liquid Substances 0.000 description 2
- 238000000034 method Methods 0.000 description 2
- 238000002156 mixing Methods 0.000 description 2
- 229920000570 polyether Polymers 0.000 description 2
- 229920000642 polymer Polymers 0.000 description 2
- 229920001155 polypropylene Polymers 0.000 description 2
- 229920002223 polystyrene Polymers 0.000 description 2
- 230000003014 reinforcing effect Effects 0.000 description 2
- 239000011347 resin Substances 0.000 description 2
- 229920005989 resin Polymers 0.000 description 2
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 2
- 238000003466 welding Methods 0.000 description 2
- HTTJABKRGRZYRN-UHFFFAOYSA-N Heparin Chemical compound OC1C(NC(=O)C)C(O)OC(COS(O)(=O)=O)C1OC1C(OS(O)(=O)=O)C(O)C(OC2C(C(OS(O)(=O)=O)C(OC3C(C(O)C(O)C(O3)C(O)=O)OS(O)(=O)=O)C(CO)O2)NS(O)(=O)=O)C(C(O)=O)O1 HTTJABKRGRZYRN-UHFFFAOYSA-N 0.000 description 1
- 229920003171 Poly (ethylene oxide) Polymers 0.000 description 1
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 1
- 208000007536 Thrombosis Diseases 0.000 description 1
- 230000001154 acute effect Effects 0.000 description 1
- 238000004026 adhesive bonding Methods 0.000 description 1
- 230000002965 anti-thrombogenic effect Effects 0.000 description 1
- 230000015572 biosynthetic process Effects 0.000 description 1
- 239000008280 blood Substances 0.000 description 1
- 210000004369 blood Anatomy 0.000 description 1
- 150000001875 compounds Chemical class 0.000 description 1
- 230000006378 damage Effects 0.000 description 1
- 238000007598 dipping method Methods 0.000 description 1
- 239000013536 elastomeric material Substances 0.000 description 1
- 238000009472 formulation Methods 0.000 description 1
- 230000004927 fusion Effects 0.000 description 1
- 229960002897 heparin Drugs 0.000 description 1
- 229920000669 heparin Polymers 0.000 description 1
- 229920001903 high density polyethylene Polymers 0.000 description 1
- 239000004700 high-density polyethylene Substances 0.000 description 1
- 238000001802 infusion Methods 0.000 description 1
- 230000002452 interceptive effect Effects 0.000 description 1
- 229920000126 latex Polymers 0.000 description 1
- 230000014759 maintenance of location Effects 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 238000000465 moulding Methods 0.000 description 1
- 239000003960 organic solvent Substances 0.000 description 1
- 230000037361 pathway Effects 0.000 description 1
- 230000035515 penetration Effects 0.000 description 1
- 230000000704 physical effect Effects 0.000 description 1
- 229920003229 poly(methyl methacrylate) Polymers 0.000 description 1
- 229920001707 polybutylene terephthalate Polymers 0.000 description 1
- 229920000515 polycarbonate Polymers 0.000 description 1
- 239000004417 polycarbonate Substances 0.000 description 1
- 229920000139 polyethylene terephthalate Polymers 0.000 description 1
- 239000005020 polyethylene terephthalate Substances 0.000 description 1
- 229920002338 polyhydroxyethylmethacrylate Polymers 0.000 description 1
- 229920001195 polyisoprene Polymers 0.000 description 1
- 239000004926 polymethyl methacrylate Substances 0.000 description 1
- 229920001296 polysiloxane Polymers 0.000 description 1
- 229920001343 polytetrafluoroethylene Polymers 0.000 description 1
- 239000004810 polytetrafluoroethylene Substances 0.000 description 1
- 229920000874 polytetramethylene terephthalate Polymers 0.000 description 1
- 239000004800 polyvinyl chloride Substances 0.000 description 1
- 229920000915 polyvinyl chloride Polymers 0.000 description 1
- 238000002360 preparation method Methods 0.000 description 1
- 238000002407 reforming Methods 0.000 description 1
- 230000000717 retained effect Effects 0.000 description 1
- 229920005573 silicon-containing polymer Polymers 0.000 description 1
- 239000002904 solvent Substances 0.000 description 1
- 238000005507 spraying Methods 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 238000009736 wetting Methods 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M25/00—Catheters; Hollow probes
- A61M25/0067—Catheters; Hollow probes characterised by the distal end, e.g. tips
- A61M25/0068—Static characteristics of the catheter tip, e.g. shape, atraumatic tip, curved tip or tip structure
- A61M25/0069—Tip not integral with tube
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M25/00—Catheters; Hollow probes
- A61M25/01—Introducing, guiding, advancing, emplacing or holding catheters
- A61M25/06—Body-piercing guide needles or the like
- A61M25/0662—Guide tubes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M39/00—Tubes, tube connectors, tube couplings, valves, access sites or the like, specially adapted for medical use
- A61M39/02—Access sites
- A61M39/06—Haemostasis valves, i.e. gaskets sealing around a needle, catheter or the like, closing on removal thereof
- A61M39/0606—Haemostasis valves, i.e. gaskets sealing around a needle, catheter or the like, closing on removal thereof without means for adjusting the seal opening or pressure
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M39/00—Tubes, tube connectors, tube couplings, valves, access sites or the like, specially adapted for medical use
- A61M39/02—Access sites
- A61M39/06—Haemostasis valves, i.e. gaskets sealing around a needle, catheter or the like, closing on removal thereof
- A61M2039/062—Haemostasis valves, i.e. gaskets sealing around a needle, catheter or the like, closing on removal thereof used with a catheter
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M39/00—Tubes, tube connectors, tube couplings, valves, access sites or the like, specially adapted for medical use
- A61M39/02—Access sites
- A61M39/06—Haemostasis valves, i.e. gaskets sealing around a needle, catheter or the like, closing on removal thereof
- A61M2039/0633—Haemostasis valves, i.e. gaskets sealing around a needle, catheter or the like, closing on removal thereof the seal being a passive seal made of a resilient material with or without an opening
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M39/00—Tubes, tube connectors, tube couplings, valves, access sites or the like, specially adapted for medical use
- A61M39/02—Access sites
- A61M39/06—Haemostasis valves, i.e. gaskets sealing around a needle, catheter or the like, closing on removal thereof
- A61M2039/0633—Haemostasis valves, i.e. gaskets sealing around a needle, catheter or the like, closing on removal thereof the seal being a passive seal made of a resilient material with or without an opening
- A61M2039/0646—Duckbill-valve
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M39/00—Tubes, tube connectors, tube couplings, valves, access sites or the like, specially adapted for medical use
- A61M39/02—Access sites
- A61M39/06—Haemostasis valves, i.e. gaskets sealing around a needle, catheter or the like, closing on removal thereof
- A61M2039/0686—Haemostasis valves, i.e. gaskets sealing around a needle, catheter or the like, closing on removal thereof comprising more than one seal
Definitions
- the invention relates to catheter introducers or sheaths which are inserted through the skin into a blood vessel or other body cavity to enable easy insertion, placement and withdrawal of a catheter without perforation or excess trauma to the blood vessel or cavity wall.
- Prior art introducers for blood vessels generally include a thin wall tube, commonly known as a sheath, which has its distal end inserted through the skin into the blood vessel.
- a hub or valve housing is attached to the proximal end of the tube and contains a valve and seal structure through which a catheter is inserted into the tube and then into the blood vessel.
- the catheter is advanced, by using longitudinal and rotative motion, in a sometimes tortuous path through various blood vessels to place the catheter tip in the desired position.
- the thin wall tube which extends for a short distance in the lumen of the blood vessel, protects the blood vessel adjacent the entrance site against perforation and abrasion from the catheter during its insertion and placement, and together with the valve and seal structure, maintains a fluid-tight relationship with the blood vessel to prevent leakage.
- a Seldinger type needle is often used to pierce a path through the skin and underlying tissue into the blood vessel.
- a guide wire is inserted through the needle and into the blood vessel after which the needle is withdrawn over the guide wire.
- the introducer may also include a side port downstream from the valve and seal in the housing for allowing withdrawal or infusion of fluids, such as heparin, through the introducer while the catheter is in place.
- Introducer tubes must have sufficient strength, rigidity, and lubricity to enable ' insertion of the introducer tube into the blood vessel and to provide a low resistance pathway for a catheter being threaded into the blood vessel.
- these requirements for strength, rigidity, and lubricity could only be met with tubes formed from polytetrafluoroethylene or high density polyethylene. Due to the relative stiffness of the sheath, and the edge sharpness resulting from the thin wall, there is a tendency for the sheath to abrade or perforate the vessel wall either during insertion or patient movement. Also introducer tube tips have been known to split or fracture during the insertion process as a result of forces created upon being forced into body tissue.
- U.S. Patent No. 4,563,181 discloses a tubular body portion of a catheter formed from nylon-11 with a soft tubular tip formed from a blend of nylon-11 and an ester linked polyether-polyamide copolymer commonly known as polyether block amide (PEBA) fused onto the distal end of the tubular body portion.
- PEBA polyether block amide
- the disclosed hydrogel material has been successfully coated on polyurethane catheters and silicone wound drains. It has been disclosed that the hydrogel material will also adhere to polyvinyl chloride, polymethyl methacrylate, polycarbonate, polyethylene terephthalate, polybutylene terephthalate, polytetramethylene terephthalate, latex rubber and polyisoprene.
- the hydrogel material can be applied to fluorocarbons- and poly ⁇ lefins which have been subjected to surface preparation to assure adequate wetting and bonding of the coating. The coating, when exposed to water, swells and develops a low coefficient of friction.
- a catheter introducer having a body portion formed from a thin- walled flexible tube with an attached soft flexible tip for extending into a body cavity or blood vessel to guide a catheter during insertion and placement of the catheter in the cavity or vessel.
- a valve and seal structure is attached to a proximal end of the body portion for closing the proximal end of the body portion when the catheter is withdrawn and for forming a seal at the proximal end during insertion and placement of the catheter to prevent leakage.
- the tip portion is formed from a polymer material rendering the tip portion substantially more flexible than the tube forming the body portion.
- An advantage of the invention is that a soft tip on an introducer does not impede forcing of the introducer into a blood vessel.
- One feature of the invention is that a soft tip on an introducer, in addition to reducing abrasion and perforation of a vessel wall, enables the tip portion to bend through a substantially greater curvature without buckling.
- a soft tip on an introducer provides a region of greater elasticity on the tip portion of the introducer to enable the tip to absorb stress during insertion of an introducer into a blood vessel or during insertion and placement of a catheter to avoid splitting of the tip.
- a soft flexible tip readily follows the bending of a guide wire during insertion to avoid snagging on tissue during insertion to thus reduce tissue trauma, and buckling or bending tendencies.
- Still another feature of the invention is the employment of a highly lubricious coating on the internal and/or external surfaces of the sheath portion of an introducer for reducing strength and rigidity requirements of the introducer to withstand forces during insertion in a blood vessel and during placement of a catheter.
- Fig. 1 is a side view, with a portion broken away, of a catheter introducer system in accordance with the invention.
- Fig. 2 is a sectional view of an introducer and dilator assembly of the system of Fig. 1.
- Fig. 3 is an enlarged side view of a valve and seal unit of the introducer of Figs. 1 and 2.
- Fig. 4 is a sectional view, with a portion exploded, of the valve and seal unit of Fig. 3.
- Fig. 5 is a top view of the valve and seal unit of . 3 and 4.
- Fig. 6 is a sectional view of a valve and seal for oy ent in the unit of Figs. 3 and 4.
- Fig. 7 is a top view of the valve and seal of Fig.
- Fig. 8 is a bottom view of the valve and seal of
- the short soft tip 26 does not interfere with forcing of the distal end of the introducer through tissue into a blood vessel or body cavity, but rather the greater elasticity and flexibility of the soft tip enables the tip to bend more sharply without snagging, buckling or folding while following the curvature of the guide wire through the tissue. Lubricity of the hydrogel coating 80 on the external surface of the tip 26 assists forcing of the tip 26 through the tissue.
- the soft tip 26 produces less trauma to tissue during insertion, and to the blood vessel wall during catheter placement or patient movement.
- the tubular body 24 is formed from a polymeric material, such as polyamide, polyethylene, polypropylene, or copolymers thereof.
- the tubular tip 26 is formed from a similar attachable polymeric material but of a softer and more flexible .compound thereof.
- Particularly preferred polymeric materials for the body 24 and the tip 26 are nylon and ester linked polyether-polyamide copolymer or blends thereof in proportions selected to produce desired properties for the body 24 and the tip 26.
- the preferred nylon is unplasticized nylon-11.
- the ester linked polyether- polyamide co-polymer material is commonly known as polyether block amide (PEBA) . This copolymer is chemically represented as:
- PA is a polyamide and PE is a polyether and where N is an integer greater than 1 representing the number of blocks of copolymer molecular units within the molecular formula of the copolymer.
- the copolymer is commercially available in a variety of molecular weights or formulations which are designated by their physical properties such as Shore hardness, tensile strength, and elongation. Copolymers of polyamide and polyether having a Shore hardness in the range from 25D to 70D are generally suitable for use in blends forming the body 24 and/or tip 26.
- Preferred PEBA copolymers for blending with nylon-11 to form the body 24 have a Shore hardness in the range from 40D to 65D, and preferred PEBA copolymers for blending with nylon-11 to form the flexible tip 26 have a Shore hardness in the range from 30D to* 50D.
- the polymer materials forming the body 24 and the tip 26 of the introducer can include from 0% to 100% by weight PEBA copolymer and from 100% to 0% by weight • nylon-11.
- the nylon-PEBA blend preferably includes from.0 to 50 percent by weight PEBA copolymer, and for the soft flexible tip 26, the nylon- PEBA blend preferably includes from 50 to 100 percent by weight PEBA.
- the Shore hardness of the PEBA and the percentages of PEBA and nylon-11 in the body portion 24 are selected such that the body portion 24 can be formed with a thin wall which has sufficient rigidity and columnar strength to withstand the forces applied by a physician to drive the sheath through tissue stretched by the dilator around an opening through which a guide wire extends.
- the Shore hardness of the PEBA and the percentages of PEBA and nylon-11 in the tip portion 26 are selected in conjunction with the length of the tip portion 26 so that the tip 26 is substantially softer and more flexible than the body portion 24 so as to substantially reduce the tendency to abrade or perforate the wall of the blood vessel and to permit the tip portion to flex and closely follow a curvature of a guide wire to prevent snagging, buckling, or splitting of the tip without substantially interfering with capability of the tip to be forced through tissue during insertion into a blood vessel.
- the tip 26 For a short tip portion 26 having a length from 0.5 inches (1.2 cm) to 1 inch (2.5 cm), the tip 26 has a hardness, as measured by Shore hardness, which is from 25 to 75 percent of the hardness of the body portion 24. Shorter tip portions can be softer while longer tip portions require more rigidity and columnar strength.
- the body portion 24 is formed from a blend of nylon-11 and PEBA having a Shore hardness of 55D wherein nylon-11 is 60 percent by weight of the mixture and PEBA is 40 percent by weight of the mixture.
- the tip portion 24 has a length of 0.75 inches (1.9 cm) and is formed from a blend of nylon-11 and PEBA having a Shore hardness of 40D wherein nylon-11 is 35 percent by weight of the mixture and PEBA is 65 percent by weight of the mixture.
- the sheath 36 has a wall thickness in the range from 0.004 to 0.006 inches (0.10 to 0.15 mm).
- a wall thickness in the range from 0.004 to 0.006 inches (0.10 to 0.15 mm).
- the sheath 36 has an external diameter of about 0.137 inches (3.48 mm) and the tapered distal end 34 has an internal diameter of about 0.109 inches (2.77 mm).
- the diameter of the sheath 36 is generally about 0.8 mm larger than the diameter of the catheter and the opening 34 is generally about 0.1 mm larger than the diameter of the catheter.
- a typical introducer has a total shield length of about 4.75 inches (12 cm).
- the tip 26 is thermally or chemically attached to the body 24.
- Region 32 is the region of bond and generally includes a varying mixture resulting from chemical or thermal fusion of the materials of the body 24 and tip 26.
- the bond is formed in a manner to produce continuous smooth inner and outer walls from the body 24 to the tip 26.
- the extreme distal end 34 of the tip 26 is tapered so that the end 34 provides a gradual or smooth increase in diameter from the dilator tube to enable easy insertion through tissue.
- the valve and seal structure 28 has a generally tubular housing 40 with a seal and valve retaining cap or ring 42 wherein the housing 40 and ring 42 are formed from polyamide, polyethylene, polystyrene, or other suitable resin.
- the housing 40 defines a cavity or chamber 44. with a port 46 for introducing or withdrawing fluid through the introducer sheath 36.
- a valve 50 for closing the rear end of the chamber 44 when a catheter is not present
- a seal 52 for sealing the rear of the chamber with the external diameter of a catheter extending through seal and valve arrangement.
- the forward end 54 of the chamber 44 is tapered down to the internal diameter of the tubular body 24 to facilitate introduction of the catheter into the tube 24 which is secured in a forward enlarged portion 56 of a front opening of the chamber 44 in the housing 40.
- the attachment of the tube 24 to the housing 40 and the attachment of the holding ring 42 to the housing 40 are accomplished by ultrasonic welding, RF welding, solvent bonding, adhesive bonding, insert molding, or any other conventional attaching technique.
- the size of the chamber 44 and the spacing of the port 46, valve 50, and termination point of the tube 24 is such that minimal spacing is achieved between the valve 50 and the forward end of the chamber 44 without causing obstruction of the port 46 from expansion of the valve 50 by the presence of a catheter.
- valve 50 The spacing between the valve 50 and the narrow end of the conical wall 54 is sufficiently short such that catheters with preformed acute angles being inserted into the catheter are prevented from reforming to their preformed curvature from the substantially straightened condition in which they are inserted into the introducer. Also the forward exit point of the valve 50, for a catheter being inserted into the introducer, is even with the • port 46 so that the tip of the catheter will not engage the port opening which otherwise could cause folding or obstruction of the catheter being inserted.
- a unitary valve and seal structure 60 shown in Figs. 7, 8 and 9, may be used in the housing 40.
- the unitary valve and seal structure 60 has a rear disc-like seal portion 62, and a conical valve portion 64 which terminates in a forward disc portion 66 with a slit 68.
- a further alternative unitary valve and seal structure 70 shown in Figs. 9 and 10, employs a tubular or cylindrical valve portion 72 with a forward end wall 74 in which the valve slit 76 is formed.
- the tubular portion 72 has a necked down central portion 78 which, with the seal portion 62, forms a double seal arrangement.
- valve 50, the seal 52, and the unitary valve and seal structures 60 and 70 are formed from an elastomeric material, such as a silicone polymer, permits easy insertion of a catheter but forms an effective valve and seal preventing leakage of fluids from the introducer.
- elastomeric material such as a silicone polymer
- the lubricious hydrophilic coating 80 is provided on both inner and outer surfaces of the sheath 36, the internal surface of the housing 40, and the surfaces of the valve and seal structures 50, 52, 60 and 70.
- the lubricious hydrophilic coating 80 is a biocompatible hydrogel material such as a copolymer of polyurethane and polyvinylpyrrolidone or cross-linked copolymer of polyethylene oxide and polyhydroxyethyl methacrylate.
- the hydrogel material is commercially available in solutions having from 1 to 3 parts by weight polyvinylpyrrolidone to 1 part polyurethane.
- Preferred hydrogel materials for catheters have 2 to 3 parts by weight polyvinylpyrrolidone to 1 part polyurethane.
- Copolymers of polyurethane and polyvinylpyrrolidone have the advantage of being highly anti-thrombogenic.
- the hydrogel copolymer is dissolved in a mixture of liquid organic solvents and is applied by flushing, dipping, or spraying the solution on the parts or portions of the introducer to be coated to form a thin layer.
- the liquid layer is then dried and cured in an oven forming a final layer 80 which is about 1 mil (0.025 mm) thick.
- the layer 80 when wetted with water such as during flushing saline solution before placing in use, swells and becomes slippery.
- the dilator 22 is a conventional type dilator with a tube 90 having a tapered leading end 92 and a luer fitting member 94 attached to the proximal end.
- the tube 90 is formed from any suitable polymer, e.g. polyamide, polyethylene, polypropylene, or copolymers thereof, and the member 94 is formed from any suitable polymer, e.g. polyamide, polyethylene, polystyrene, or other suitable resin.
- the fitting member 94 has a forward extending portion 95 which releasably locks with the housing cap 42, such as by snap fitting or wedge fitting into the rear opening of the housing cap so as to maintain the dilator position in the introducer during insertion into a blood vessel.
Abstract
A catheter introducer has a tubular sheath with a relatively rigid tubular body (24) and a soft flexible tubular tip (26) for reducing sheath buckling tendencies. A coating (80) of lubricious hydrogel eases insertion through tissue and eases catheter insertion through the introducer.
Description
CATHETER INTRODUCER WITH FLEXIBLE TIP
BACKGROUND Field of the Invention
The invention relates to catheter introducers or sheaths which are inserted through the skin into a blood vessel or other body cavity to enable easy insertion, placement and withdrawal of a catheter without perforation or excess trauma to the blood vessel or cavity wall. Description of the Prior Art
Prior art introducers for blood vessels generally include a thin wall tube, commonly known as a sheath, which has its distal end inserted through the skin into the blood vessel. A hub or valve housing is attached to the proximal end of the tube and contains a valve and seal structure through which a catheter is inserted into the tube and then into the blood vessel. The catheter is advanced, by using longitudinal and rotative motion, in a sometimes tortuous path through various blood vessels to place the catheter tip in the desired position. The thin wall tube, which extends for a short distance in the lumen of the blood vessel, protects the blood vessel adjacent the entrance site against perforation and abrasion from the catheter during its insertion and placement, and together with the valve and seal structure, maintains a fluid-tight relationship with the blood vessel to prevent leakage.
To insert the introducer into the blood vessel, a Seldinger type needle is often used to pierce a path through the skin and underlying tissue into the blood vessel. A guide wire is inserted through the needle and into the blood vessel after which the needle is withdrawn over the guide wire. Then an assembly of the introducer with a tubular dilator extending through the lumen of the introducer is slipped over the guide wire with the tips of the dilator and introducer being forced into the blood vessel. The dilator and guide wire are removed leaving the introducer in position to receive and guide the catheter into the blood vessel. The introducer may also include a side port downstream from the valve and seal in the housing for allowing withdrawal or infusion of fluids, such as heparin, through the introducer while the catheter is in place.
Introducer tubes must have sufficient strength, rigidity, and lubricity to enable' insertion of the introducer tube into the blood vessel and to provide a low resistance pathway for a catheter being threaded into the blood vessel. Generally these requirements for strength, rigidity, and lubricity could only be met with tubes formed from polytetrafluoroethylene or high density polyethylene. Due to the relative stiffness of the sheath, and the edge sharpness resulting from the thin wall, there is a tendency for the sheath to abrade or perforate the vessel wall either during insertion or patient movement. Also introducer tube tips have been known to split or fracture during the insertion process as a result of forces created upon being forced into body tissue.
Another problem associated with prior art introducers is the tendency for the thin walled tube to
buckle or fold during insertion. The rigidity of the tube sometimes causes the wire guide to bend or fold or the tip to snag on tissue to thus lead to a buildup of forces in the tube to cause the buckling or folding of the tube commonly near to the junction of the housing with the tube. These folds have been known to impede catheter introduction or to restrict fluid delivery. Also these folds can promote thrombus formation due to blood retention at the fold site. U.S. Patent No 4,610,674 discloses a catheter introducer having a reinforcing coil body fitted in a connecting portion of the hub and extending axially of the sheath from the connection portion toward the distal end of the sheath beyond the connection portion. The reinforcing coil prevents folding of the sheath at the junction of the sheath and hub.
Soft tips are commonly employed on catheters in order to avoid injury to blood vessels. For example, U.S. Patent No. 4,563,181 discloses a tubular body portion of a catheter formed from nylon-11 with a soft tubular tip formed from a blend of nylon-11 and an ester linked polyether-polyamide copolymer commonly known as polyether block amide (PEBA) fused onto the distal end of the tubular body portion. The tips of catheters are made soft so that they avoid penetration through blood vessel walls.
The use of a coating of hydrogel material including polyvinylpyrrolidone-polyurethane interpolymer on catheters to reduce insertion friction and to reduce thrombogenicity is disclosed in U.S.
Patent No. 4,100,309 to Micklus et al. The disclosed hydrogel material has been successfully coated on polyurethane catheters and silicone wound drains. It has been disclosed that the hydrogel material will also
adhere to polyvinyl chloride, polymethyl methacrylate, polycarbonate, polyethylene terephthalate, polybutylene terephthalate, polytetramethylene terephthalate, latex rubber and polyisoprene. The hydrogel material can be applied to fluorocarbons- and polyσlefins which have been subjected to surface preparation to assure adequate wetting and bonding of the coating. The coating, when exposed to water, swells and develops a low coefficient of friction. SUMMARY OF THE INVENTION
The invention is summarized in a catheter introducer having a body portion formed from a thin- walled flexible tube with an attached soft flexible tip for extending into a body cavity or blood vessel to guide a catheter during insertion and placement of the catheter in the cavity or vessel. A valve and seal structure is attached to a proximal end of the body portion for closing the proximal end of the body portion when the catheter is withdrawn and for forming a seal at the proximal end during insertion and placement of the catheter to prevent leakage. The tip portion is formed from a polymer material rendering the tip portion substantially more flexible than the tube forming the body portion. An object of the invention is to construct a new and improved catheter introducer with reduced tendency to split or buckle or to abrade or traumatize a vessel wall during use.
An advantage of the invention is that a soft tip on an introducer does not impede forcing of the introducer into a blood vessel.
One feature of the invention is that a soft tip on an introducer, in addition to reducing abrasion and perforation of a vessel wall, enables the tip portion
to bend through a substantially greater curvature without buckling.
Another feature of the invention is that a soft tip on an introducer provides a region of greater elasticity on the tip portion of the introducer to enable the tip to absorb stress during insertion of an introducer into a blood vessel or during insertion and placement of a catheter to avoid splitting of the tip. A further feature of the invention is that a soft flexible tip readily follows the bending of a guide wire during insertion to avoid snagging on tissue during insertion to thus reduce tissue trauma, and buckling or bending tendencies.
Still another feature of the invention is the employment of a highly lubricious coating on the internal and/or external surfaces of the sheath portion of an introducer for reducing strength and rigidity requirements of the introducer to withstand forces during insertion in a blood vessel and during placement of a catheter.
Other objects, advantages, and features will be apparent from the following description of the preferred embodiments taken in conjunction with the accompanying drawings BRIEF DESCRIPTION OF THE DRAWINGS
Fig. 1 is a side view, with a portion broken away, of a catheter introducer system in accordance with the invention.
Fig. 2 is a sectional view of an introducer and dilator assembly of the system of Fig. 1.
Fig. 3 is an enlarged side view of a valve and seal unit of the introducer of Figs. 1 and 2.
Fig. 4 is a sectional view, with a portion exploded, of the valve and seal unit of Fig. 3.
Fig. 5 is a top view of the valve and seal unit of . 3 and 4.
Fig. 6 is a sectional view of a valve and seal for oy ent in the unit of Figs. 3 and 4. 5 Fig. 7 is a top view of the valve and seal of Fig.
Fig. 8 is a bottom view of the valve and seal of
Surprisingly, the short soft tip 26 does not interfere with forcing of the distal end of the introducer through tissue into a blood vessel or body cavity, but rather the greater elasticity and flexibility of the soft tip enables the tip to bend more sharply without snagging, buckling or folding while following the curvature of the guide wire through the tissue. Lubricity of the hydrogel coating 80 on the external surface of the tip 26 assists forcing of the tip 26 through the tissue. The soft tip 26 produces less trauma to tissue during insertion, and to the blood vessel wall during catheter placement or patient movement.
The tubular body 24 is formed from a polymeric material, such as polyamide, polyethylene, polypropylene, or copolymers thereof. The tubular tip 26 is formed from a similar attachable polymeric material but of a softer and more flexible .compound thereof. Particularly preferred polymeric materials for the body 24 and the tip 26 are nylon and ester linked polyether-polyamide copolymer or blends thereof in proportions selected to produce desired properties for the body 24 and the tip 26. The preferred nylon is unplasticized nylon-11. The ester linked polyether- polyamide co-polymer material is commonly known as polyether block amide (PEBA) . This copolymer is chemically represented as:
where PA is a polyamide and PE is a polyether and where N is an integer greater than 1 representing the number of blocks of copolymer molecular units within the
molecular formula of the copolymer. The copolymer is commercially available in a variety of molecular weights or formulations which are designated by their physical properties such as Shore hardness, tensile strength, and elongation. Copolymers of polyamide and polyether having a Shore hardness in the range from 25D to 70D are generally suitable for use in blends forming the body 24 and/or tip 26. Preferred PEBA copolymers for blending with nylon-11 to form the body 24 have a Shore hardness in the range from 40D to 65D, and preferred PEBA copolymers for blending with nylon-11 to form the flexible tip 26 have a Shore hardness in the range from 30D to* 50D.
The polymer materials forming the body 24 and the tip 26 of the introducer can include from 0% to 100% by weight PEBA copolymer and from 100% to 0% by weight • nylon-11. For the body 24, the nylon-PEBA blend preferably includes from.0 to 50 percent by weight PEBA copolymer, and for the soft flexible tip 26, the nylon- PEBA blend preferably includes from 50 to 100 percent by weight PEBA.
The Shore hardness of the PEBA and the percentages of PEBA and nylon-11 in the body portion 24 are selected such that the body portion 24 can be formed with a thin wall which has sufficient rigidity and columnar strength to withstand the forces applied by a physician to drive the sheath through tissue stretched by the dilator around an opening through which a guide wire extends. The Shore hardness of the PEBA and the percentages of PEBA and nylon-11 in the tip portion 26 are selected in conjunction with the length of the tip portion 26 so that the tip 26 is substantially softer and more flexible than the body portion 24 so as to substantially reduce the tendency to abrade or
perforate the wall of the blood vessel and to permit the tip portion to flex and closely follow a curvature of a guide wire to prevent snagging, buckling, or splitting of the tip without substantially interfering with capability of the tip to be forced through tissue during insertion into a blood vessel. For a short tip portion 26 having a length from 0.5 inches (1.2 cm) to 1 inch (2.5 cm), the tip 26 has a hardness, as measured by Shore hardness, which is from 25 to 75 percent of the hardness of the body portion 24. Shorter tip portions can be softer while longer tip portions require more rigidity and columnar strength.
In one specific example of an introducer, the body portion 24 is formed from a blend of nylon-11 and PEBA having a Shore hardness of 55D wherein nylon-11 is 60 percent by weight of the mixture and PEBA is 40 percent by weight of the mixture. The tip portion 24 has a length of 0.75 inches (1.9 cm) and is formed from a blend of nylon-11 and PEBA having a Shore hardness of 40D wherein nylon-11 is 35 percent by weight of the mixture and PEBA is 65 percent by weight of the mixture.
Typically the sheath 36 has a wall thickness in the range from 0.004 to 0.006 inches (0.10 to 0.15 mm). For an introducer designed to accommodate an 8 French
(2.67 mm external diameter) catheter, the sheath 36 has an external diameter of about 0.137 inches (3.48 mm) and the tapered distal end 34 has an internal diameter of about 0.109 inches (2.77 mm). For introducers accommodating smaller catheters down to 4 French (1.33 mm) the diameter of the sheath 36 is generally about 0.8 mm larger than the diameter of the catheter and the opening 34 is generally about 0.1 mm larger than the
diameter of the catheter. A typical introducer has a total shield length of about 4.75 inches (12 cm).
The tip 26 is thermally or chemically attached to the body 24. Region 32 is the region of bond and generally includes a varying mixture resulting from chemical or thermal fusion of the materials of the body 24 and tip 26. The bond is formed in a manner to produce continuous smooth inner and outer walls from the body 24 to the tip 26. The extreme distal end 34 of the tip 26 is tapered so that the end 34 provides a gradual or smooth increase in diameter from the dilator tube to enable easy insertion through tissue.
As illustrated in Figs. 3 and 4, the valve and seal structure 28 has a generally tubular housing 40 with a seal and valve retaining cap or ring 42 wherein the housing 40 and ring 42 are formed from polyamide, polyethylene, polystyrene, or other suitable resin. The housing 40 defines a cavity or chamber 44. with a port 46 for introducing or withdrawing fluid through the introducer sheath 36. Retained between the ring 42 and an annular rearward facing ledge 48 of the housing 40 at the rear end of the chamber 44 are a valve 50 for closing the rear end of the chamber 44 when a catheter is not present and a seal 52 for sealing the rear of the chamber with the external diameter of a catheter extending through seal and valve arrangement. The forward end 54 of the chamber 44 is tapered down to the internal diameter of the tubular body 24 to facilitate introduction of the catheter into the tube 24 which is secured in a forward enlarged portion 56 of a front opening of the chamber 44 in the housing 40. The attachment of the tube 24 to the housing 40 and the attachment of the holding ring 42 to the housing 40 are accomplished by ultrasonic welding, RF welding, solvent
bonding, adhesive bonding, insert molding, or any other conventional attaching technique. The size of the chamber 44 and the spacing of the port 46, valve 50, and termination point of the tube 24 is such that minimal spacing is achieved between the valve 50 and the forward end of the chamber 44 without causing obstruction of the port 46 from expansion of the valve 50 by the presence of a catheter. The spacing between the valve 50 and the narrow end of the conical wall 54 is sufficiently short such that catheters with preformed acute angles being inserted into the catheter are prevented from reforming to their preformed curvature from the substantially straightened condition in which they are inserted into the introducer. Also the forward exit point of the valve 50, for a catheter being inserted into the introducer, is even with the • port 46 so that the tip of the catheter will not engage the port opening which otherwise could cause folding or obstruction of the catheter being inserted. As an alternative to the separate seal and valve structures of Fig. 4, a unitary valve and seal structure 60, shown in Figs. 7, 8 and 9, may be used in the housing 40. The unitary valve and seal structure 60 has a rear disc-like seal portion 62, and a conical valve portion 64 which terminates in a forward disc portion 66 with a slit 68. A further alternative unitary valve and seal structure 70, shown in Figs. 9 and 10, employs a tubular or cylindrical valve portion 72 with a forward end wall 74 in which the valve slit 76 is formed. The tubular portion 72 has a necked down central portion 78 which, with the seal portion 62, forms a double seal arrangement. The valve 50, the seal 52, and the unitary valve and seal structures 60 and 70 are formed from an elastomeric material, such as
a silicone polymer, permits easy insertion of a catheter but forms an effective valve and seal preventing leakage of fluids from the introducer.
The lubricious hydrophilic coating 80, Fig. 11, is provided on both inner and outer surfaces of the sheath 36, the internal surface of the housing 40, and the surfaces of the valve and seal structures 50, 52, 60 and 70. The lubricious hydrophilic coating 80 is a biocompatible hydrogel material such as a copolymer of polyurethane and polyvinylpyrrolidone or cross-linked copolymer of polyethylene oxide and polyhydroxyethyl methacrylate. The hydrogel material is commercially available in solutions having from 1 to 3 parts by weight polyvinylpyrrolidone to 1 part polyurethane. Preferred hydrogel materials for catheters have 2 to 3 parts by weight polyvinylpyrrolidone to 1 part polyurethane. Copolymers of polyurethane and polyvinylpyrrolidone have the advantage of being highly anti-thrombogenic. The hydrogel copolymer is dissolved in a mixture of liquid organic solvents and is applied by flushing, dipping, or spraying the solution on the parts or portions of the introducer to be coated to form a thin layer. The liquid layer is then dried and cured in an oven forming a final layer 80 which is about 1 mil (0.025 mm) thick. The layer 80, when wetted with water such as during flushing saline solution before placing in use, swells and becomes slippery.
The dilator 22 is a conventional type dilator with a tube 90 having a tapered leading end 92 and a luer fitting member 94 attached to the proximal end. The tube 90 is formed from any suitable polymer, e.g. polyamide, polyethylene, polypropylene, or copolymers thereof, and the member 94 is formed from any suitable
polymer, e.g. polyamide, polyethylene, polystyrene, or other suitable resin. The fitting member 94 has a forward extending portion 95 which releasably locks with the housing cap 42, such as by snap fitting or wedge fitting into the rear opening of the housing cap so as to maintain the dilator position in the introducer during insertion into a blood vessel.
Since many modifications, variations, and changes in detail may be made to the above described embodiments, it is intended that all matter described in the foregoing description and shown in the accompanying drawings be interpreted as only illustrative not as limiting to the scope and spirit of the invention as defined in the following claims.
Claims
1. A catheter introducer comprising a body portion (24) formed from a thin-walled flexible tube for extending into a body cavity or blood vessel to guide a catheter (22) during insertion and placement of the catheter in the cavity or vessel, said tube forming the body portion having sufficient rigidity and columnar strength to withstand forces applied by a physician to drive the introducer through tissue stretched by a dilator around an opening through which a guide wire extends, characterized by a tip portion (26) formed from a thin-walled flexible tube attached to the distal end of the body portion, said tube forming the tip portion including a polymer material rendering the tip portion substantially more flexible than the tube forming the body portion.
2. A catheter introducer as claimed in claim 1 characterized by valve and seal means (28) attached to a proximal end of the body portion (24) for closing the proximal end of the body portion when the catheter is withdrawn and for forming a seal at the proximal end during insertion and placement of the catheter to prevent leakage.
3. A catheter introducer as claimed in claim 1 or 2 characterized in that the tube forming the tip portion (26) has a Shore hardness which is from 25 to 75 percent of a Shore hardness of the tube forming the body portion.
4. A catheter introducer as claimed in claim 1 or 2 characterized in that the flexible tube forming the body portion (24) includes a nylon and from 0% to 50% ester linked polyether-polyamide copolymer, and the flexible tube forming the tip portion (26) includes a nylon and from 50% to 100% ester linked polyether- polyamide copolymer wherein the percentage of copolymer in the tip portion is substantially greater than the percentage of copolymer in the body portion so as to render the tip portion softer and more flexible than the body portion.
5. A catheter introducer as in claim 1 or 2 characterized in that all internal surfaces are coated to reduce thrombogenicity.
6. A catheter introducer as claimed in claim 1 or 2 characterized in that the flexible tube forming the body portion (24) includes nylon-11 and an ester linked polyether-polyamide copolymer, and the flexible tube forming the tip portion (26) includes nylon-11 and an ester linked polyether-polyamide copolymer, said copolymer in the tip portion having a hardness which is substantially less than the hardness of the copolymer in the body portion so as to render the tip portion softer and more flexible than the body portion.
7. A catheter introducer as claimed in claim 6 characterized in that the copolymer in the body portion (24) has a Shore hardness in the range from 40D to 70D and the copolymer in the tip portion (26) has a Shore hardness in the range from 25D to 50D.
8. A catheter introducer as claimed in claim 6 characterized in that the weight percentage of copolymer in the flexible tube forming the body portion (24) is substantially greater than the weight percentage of the copolymer in the flexible tube forming the tip portion (26).
9. A catheter introducer as claimed in claim 1, 2 or 8 characterized in that the tube forming the tip portion (26) is from 1.2 cm to 2.5 cm in length.
10. A catheter introducer as claimed in claim 1, 2 or 8 characterized in that all internal surfaces of the introducer have a coating (80) of lubricious hydrogel to promote ease of catheter insertion.
11. A catheter introducer as claimed in claim 1, 2 or 8 characterized in that the flexible tube forming the tip portion (26) has a coating (80) of lubricious hydrogel on the exterior surface to render insertion through tissue easier.
12. A catheter introducer as claimed in claim 2 characterized in that the valve and seal means (28) includes an integral valve and seal structure having a rear disc-like portion (52, 62) with an opening for receiving and sealing a catheter, and a forward conical portion (50, 64) terminating in a disc (66) with a valve slot (68) .
13. A catheter introducer as claimed in claim 2 characterized in that the valve and seal means (28) includes an integral valve and seal structure having a rear disc-like portion (62) with an opening for receiving and sealing a catheter, and a forward tubular portion (72) with a forward end wall (74) having a valve slot (76) .
14. A catheter introducer as claimed in claim 13 characterized in that the tubular portion (72) of the integral valve and seal structure has an intermediate portion (78) with an internal diameter which is necked down to form a second seal.
15. A catheter introducer comprising a thin-walled flexible tube (24, 26) for extending into a body cavity or blood vessel to guide a catheter (22) during insertion and placement of the catheter in the cavity or vessel, said tube having sufficient rigidity and columnar strength to withstand forces applied by a physician to drive the tube through tissue stretched by a dilator around an opening through which a guide wire extends; characterized by a coating (80) of lubricious hydrogel on the interior and/or exterior surface of the tube.
16. A catheter introducer as claimed in claim 15 characterized in that the coating (80) of lubricious hydrogel is on the interior surface of the tube to promote ease of catheter insertion.
17. A catheter introducer as claimed in claim 15 or 16 characterized in that the coating (80) of lubricious hydrogel is on the exterior surface to render insertion through tissue easier.
18. A catheter introducer as claimed in claim 5, 10, 11, 15, 16 or 17 characterized in that the coating or lubricious hydrogel is a copolymer of polyurethane and polyvinylpyrrolidone having from 1 to 3 parts by weight polyvinylpyrrolidone to 1 part polyurethane.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US244,290 | 1988-09-15 | ||
US07/244,290 US4950257A (en) | 1988-09-15 | 1988-09-15 | Catheter introducer with flexible tip |
Publications (2)
Publication Number | Publication Date |
---|---|
WO1990002579A2 true WO1990002579A2 (en) | 1990-03-22 |
WO1990002579A3 WO1990002579A3 (en) | 1990-10-18 |
Family
ID=22922148
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/US1989/003266 WO1990002579A2 (en) | 1988-09-15 | 1989-07-19 | Catheter introducer with flexible tip |
Country Status (4)
Country | Link |
---|---|
US (2) | US4950257A (en) |
AU (1) | AU4056489A (en) |
CA (1) | CA1322920C (en) |
WO (1) | WO1990002579A2 (en) |
Cited By (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0450221A1 (en) * | 1990-04-04 | 1991-10-09 | C.R. Bard, Inc. | Expandable soft tip sheath |
EP0499401A1 (en) * | 1991-02-14 | 1992-08-19 | Smiths Industries Plc | Resealable sampling port |
FR2694181A1 (en) * | 1992-07-31 | 1994-02-04 | Medecine Sa Ste Europ | Trocar sleeve for endoscopic examination and surgery of the body cavities. |
EP0596172A2 (en) * | 1992-11-03 | 1994-05-11 | Robert E. Fischell | Radiopaque non-kinking thin-walled introducer sheath |
EP0624380A1 (en) * | 1993-05-12 | 1994-11-17 | Cook Incorporated | Radiopaque catheter |
WO1995031226A1 (en) * | 1994-05-18 | 1995-11-23 | Schneider (Usa) Inc. | Thin wall catheter having enhanced torqueability characteristics |
WO1996004952A1 (en) * | 1994-08-08 | 1996-02-22 | Schneider (Usa) Inc. | Drug delivery and dilatation-drug delivery catheters in a rapid exchange configuration |
EP0723787A2 (en) * | 1995-01-25 | 1996-07-31 | Cordis Europa N.V. | Haemostatic device |
WO2000012167A1 (en) * | 1998-08-26 | 2000-03-09 | Microcatheters Pty. Ltd. | Catheter guide |
Families Citing this family (273)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4950257A (en) * | 1988-09-15 | 1990-08-21 | Mallinckrodt, Inc. | Catheter introducer with flexible tip |
US5304197A (en) * | 1988-10-04 | 1994-04-19 | Cordis Corporation | Balloons for medical devices and fabrication thereof |
US6500146B1 (en) | 1988-10-04 | 2002-12-31 | Cordis Corporation | Balloons for medical devices and fabrication thereof |
US5041100A (en) * | 1989-04-28 | 1991-08-20 | Cordis Corporation | Catheter and hydrophilic, friction-reducing coating thereon |
US5108369A (en) * | 1990-03-15 | 1992-04-28 | Diagnostic Devices Group, Limited | Dual-diameter multifunction catheter |
US5078700A (en) * | 1990-03-19 | 1992-01-07 | Becton, Dickinson And Company | Liquid crystalline catheter |
US5207656A (en) * | 1990-04-19 | 1993-05-04 | Cordis Corporation | Medical instrument valve having foam partition member |
US5125913A (en) * | 1990-05-11 | 1992-06-30 | Fbk International Corporation | Soft-tipped catheters |
US5395342A (en) * | 1990-07-26 | 1995-03-07 | Yoon; Inbae | Endoscopic portal |
US5250025A (en) * | 1990-08-15 | 1993-10-05 | Intramed Laboratories | Percutaneous access catheter and method of use |
US5203780A (en) * | 1990-09-05 | 1993-04-20 | Liebler William A | Vented surgical probe and method of use |
US5112308A (en) * | 1990-10-03 | 1992-05-12 | Cook Incorporated | Medical device for and a method of endoscopic surgery |
US5433713A (en) * | 1991-04-15 | 1995-07-18 | Cordis Corporation | Polyetheramide tubing for medical devices |
CA2068584C (en) * | 1991-06-18 | 1997-04-22 | Paul H. Burmeister | Intravascular guide wire and method for manufacture thereof |
US5443907A (en) * | 1991-06-18 | 1995-08-22 | Scimed Life Systems, Inc. | Coating for medical insertion guides |
US5209741A (en) * | 1991-07-08 | 1993-05-11 | Endomedix Corporation | Surgical access device having variable post-insertion cross-sectional geometry |
US5211634A (en) * | 1991-08-06 | 1993-05-18 | Vaillancourt Vincent L | Composite seal structure and a coupling arrangement for a cannula |
US5391155A (en) * | 1991-09-13 | 1995-02-21 | Sachse; Hans | Arrangement comprising a ureter tube, an auxiliary tube as well as a mandrin |
US5545142A (en) * | 1991-10-18 | 1996-08-13 | Ethicon, Inc. | Seal members for surgical trocars |
US5167636A (en) * | 1991-10-24 | 1992-12-01 | Mectra Labs, Inc. | Cannula sealing mechanism |
US6808520B1 (en) | 1991-12-13 | 2004-10-26 | Endovascular Technologies, Inc. | Dual valve, flexible expandable sheath and method |
US5207649A (en) * | 1991-12-13 | 1993-05-04 | Brigham And Women's Hospital | Introducer sheath having a hemostatic closure |
US5935122A (en) * | 1991-12-13 | 1999-08-10 | Endovascular Technologies, Inc. | Dual valve, flexible expandable sheath and method |
US6652492B1 (en) | 1991-12-13 | 2003-11-25 | Endovascular Technologies, Inc. | Dual valve, flexible sheath and method |
US5304134A (en) * | 1992-01-17 | 1994-04-19 | Danforth Biomedical, Inc. | Lubricious yet bondable catheter channel sleeve for over-the-wire catheters |
US5395352A (en) * | 1992-02-24 | 1995-03-07 | Scimed Lift Systems, Inc. | Y-adaptor manifold with pinch valve for an intravascular catheter |
US5584821A (en) * | 1992-06-02 | 1996-12-17 | E-Z-Em, Inc. | Soft tip catheter |
GR930100244A (en) * | 1992-06-30 | 1994-02-28 | Ethicon Inc | Flexible endoscopic surgical port |
US5295968A (en) * | 1992-08-19 | 1994-03-22 | Wilson-Cook Medical Inc. | Stylet wire assembly |
US5269764A (en) * | 1992-08-21 | 1993-12-14 | Devices For Vascular Intervention, Inc. | Hemostatic gasket and valve assembly |
JPH06190052A (en) * | 1992-09-18 | 1994-07-12 | Cordis Corp | Catheter insertion equipment of which fiber is reinforced |
US5500180A (en) | 1992-09-30 | 1996-03-19 | C. R. Bard, Inc. | Method of making a distensible dilatation balloon using a block copolymer |
US5342386A (en) * | 1992-10-26 | 1994-08-30 | Cordis Corporation | Catheter with multiple flexibilities along the shaft |
US5382260A (en) * | 1992-10-30 | 1995-01-17 | Interventional Therapeutics Corp. | Embolization device and apparatus including an introducer cartridge and method for delivering the same |
US5324262A (en) * | 1993-02-09 | 1994-06-28 | Cathco, Inc. | Introducer sheath with expandable outer tube and method of use |
US5380288A (en) * | 1993-03-30 | 1995-01-10 | Innovasive Devices, Inc. | Surgical cannula and trocar system and method of using the same |
US5342315A (en) * | 1993-04-12 | 1994-08-30 | Ethicon, Inc. | Trocar seal/protector assemblies |
CA2142335C (en) * | 1993-06-16 | 2005-06-21 | Oskar E. Illi | Use of and process for the introduction of fibrin sealant into a puncture channel |
US5527325A (en) * | 1993-07-09 | 1996-06-18 | Device For Vascular Intervention, Inc. | Atherectomy catheter and method |
US5417665A (en) * | 1993-10-19 | 1995-05-23 | Cordis Corporation | Intravascular cannula |
AU1332795A (en) * | 1993-11-30 | 1995-06-19 | Medex, Inc. | Plastic needleless valve housing for standard male luer locks |
AU1331595A (en) * | 1993-11-30 | 1995-06-19 | Medex, Inc. | Anti-reflux valve with environmental barrier |
US5549651A (en) * | 1994-05-25 | 1996-08-27 | Lynn; Lawrence A. | Luer-receiving medical valve and fluid transfer method |
US5522804A (en) * | 1994-02-15 | 1996-06-04 | Lynn; Lawrence A. | Aspiration, mixing, and injection syringe |
US5533986A (en) * | 1994-02-18 | 1996-07-09 | Merit Medical Systems, Inc. | Catheter apparatus with means for subcutaneous delivery of anesthetic agent or other fluid medicament |
US5772639A (en) * | 1994-02-18 | 1998-06-30 | Merit Medical Systems, Inc. | Total alimentary nutrition catheter apparatus with means for subcutaneous delivery of anesthetic agent or other fluid medicament |
US5405334A (en) * | 1994-02-18 | 1995-04-11 | Merit Medical Systems, Inc. | Catheter apparatus with means for subcutaneous delivery of anesthetic agent or other fluid medicament |
US5817072A (en) * | 1994-02-18 | 1998-10-06 | Merit Medical Systems, Inc. | Central venous system catheter apparatus with means for subcutaneous delivery of anesthetic agent of other fluid medicament |
US5647859A (en) * | 1994-02-18 | 1997-07-15 | Merit Medical Systems, Inc. | Catheter apparatus with means for subcutaneous delivery of anesthetic agent or other fluid medicament |
US5797886A (en) * | 1994-02-18 | 1998-08-25 | Merit Medical Systems, Inc. | Catheter apparatus with means for subcutaneous delivery of anesthetic agent or other fluid medicament |
US5830182A (en) * | 1994-03-02 | 1998-11-03 | Scimed Life Systems, Inc. | Block copolymer elastomer catheter balloons |
US5951941A (en) * | 1994-03-02 | 1999-09-14 | Scimed Life Systems, Inc. | Block copolymer elastomer catheter balloons |
US7163522B1 (en) | 1994-03-02 | 2007-01-16 | Scimed Life Systems, Inc. | Block copolymer elastomer catheter balloons |
DK0748232T4 (en) * | 1994-03-02 | 2009-01-19 | Boston Scient Scimed Inc | Catheter balloons of block copolymer elastomers |
US6146356A (en) * | 1994-03-02 | 2000-11-14 | Scimed Life Systems, Inc. | Block copolymer elastomer catheter balloons |
US6171278B1 (en) | 1994-03-02 | 2001-01-09 | Scimed Life Systems, Inc. | Block copolymer elastomer catheter balloons |
US6406457B1 (en) | 1994-03-02 | 2002-06-18 | Scimed Life Systems, Inc. | Block copolymer elastomer catheter balloons |
US7108826B2 (en) * | 1994-03-02 | 2006-09-19 | Boston Scientific Scimed, Inc. | High compliance, high strength catheter balloons useful for treatment of gastrointestinal lesions |
US5395341A (en) * | 1994-03-21 | 1995-03-07 | Cordis Corporation | One piece vessel dilator/catheter sheath introducer |
US5458605A (en) * | 1994-04-04 | 1995-10-17 | Advanced Cardiovascular Systems, Inc. | Coiled reinforced retractable sleeve for stent delivery catheter |
US7033339B1 (en) | 1998-05-29 | 2006-04-25 | Becton Dickinson And Company (Part Interest) | Self sealing luer receiving stopcock |
US5540661A (en) * | 1994-05-03 | 1996-07-30 | Medex, Inc. | Needleless valve having a covalently bonded lubricious coating |
US5474544A (en) * | 1994-05-25 | 1995-12-12 | Lynn; Lawrence A. | Luer-receiving medical valve |
USRE38145E1 (en) * | 1994-05-25 | 2003-06-17 | Lawrence A. Lynn | Luer-receiving medical valve |
USRE39334E1 (en) * | 1994-05-25 | 2006-10-10 | Lynn Lawrence A | Luer-receiving medical valve and fluid transfer method |
US5453095A (en) * | 1994-06-07 | 1995-09-26 | Cordis Corporation | One piece self-aligning, self-lubricating catheter valve |
US5520655A (en) * | 1994-07-15 | 1996-05-28 | Cordis Corporation | Catheter hemostasis valve |
US5765682A (en) * | 1994-10-13 | 1998-06-16 | Menlo Care, Inc. | Restrictive package for expandable or shape memory medical devices and method of preventing premature change of same |
WO1996020024A1 (en) * | 1994-12-28 | 1996-07-04 | Abbott Laboratories | Catheter insertion device with valve |
WO1996025897A2 (en) * | 1995-02-22 | 1996-08-29 | Menlo Care, Inc. | Covered expanding mesh stent |
US5938645A (en) * | 1995-05-24 | 1999-08-17 | Boston Scientific Corporation Northwest Technology Center Inc. | Percutaneous aspiration catheter system |
DE69633011T2 (en) | 1995-05-24 | 2004-12-09 | Schneider (Usa) Inc., Plymouth | POLYESTERETHERAMIDECOPOLYMER CONTAINING DILATION BALLOONS |
US5779670A (en) * | 1995-05-31 | 1998-07-14 | Bidwell; Robert E. | Catheter having lubricated sheathing |
US5897497A (en) * | 1995-07-27 | 1999-04-27 | Cordis Corporation | Guiding catheter introducer assembly |
US5603991A (en) * | 1995-09-29 | 1997-02-18 | Target Therapeutics, Inc. | Method for coating catheter lumens |
US20030069522A1 (en) * | 1995-12-07 | 2003-04-10 | Jacobsen Stephen J. | Slotted medical device |
US6440088B1 (en) * | 1996-05-24 | 2002-08-27 | Precision Vascular Systems, Inc. | Hybrid catheter guide wire apparatus and method |
US5797882A (en) * | 1996-08-23 | 1998-08-25 | Becton Dickinson And Company | Arterial catheter and catheter/needle assembly with improved flow characteristics and method for its use |
US5762637A (en) * | 1996-08-27 | 1998-06-09 | Scimed Life Systems, Inc. | Insert molded catheter tip |
US7749585B2 (en) | 1996-10-08 | 2010-07-06 | Alan Zamore | Reduced profile medical balloon element |
US7229413B2 (en) * | 1996-11-06 | 2007-06-12 | Angiotech Biocoatings Corp. | Echogenic coatings with overcoat |
US6106473A (en) | 1996-11-06 | 2000-08-22 | Sts Biopolymers, Inc. | Echogenic coatings |
US6007521A (en) * | 1997-01-07 | 1999-12-28 | Bidwell; Robert E. | Drainage catheter system |
US6142981A (en) * | 1997-01-07 | 2000-11-07 | Daig Corporation | Hemostasis valve |
US5997517A (en) | 1997-01-27 | 1999-12-07 | Sts Biopolymers, Inc. | Bonding layers for medical device surface coatings |
US5906595A (en) * | 1997-04-25 | 1999-05-25 | Ethicon Endo-Surgery, Inc. | Trocar having protector with flexible end and improved seal assembly |
DE69835498T2 (en) | 1997-05-20 | 2007-03-29 | Baxter International Inc., Deerfield | NEEDLE CLUTCH PIECE |
US5957898A (en) | 1997-05-20 | 1999-09-28 | Baxter International Inc. | Needleless connector |
US6110483A (en) * | 1997-06-23 | 2000-08-29 | Sts Biopolymers, Inc. | Adherent, flexible hydrogel and medicated coatings |
US6066126A (en) * | 1997-12-18 | 2000-05-23 | Medtronic, Inc. | Precurved, dual curve cardiac introducer sheath |
MXPA00011767A (en) | 1998-05-29 | 2002-10-17 | Lawrence A Lynn | Luer receiver and method for fluid transfer. |
US5885252A (en) * | 1998-06-03 | 1999-03-23 | Liu; Wen-Neng | Automatic safety infusion catheter needle |
JP3031338B2 (en) * | 1998-07-14 | 2000-04-10 | 文能 劉 | Multipurpose safe automatic infusion venous catheter |
US6126650A (en) * | 1998-06-30 | 2000-10-03 | Cordis Corporation | Flow directed catheter having radiopaque strain relief segment |
US6287506B1 (en) | 1998-07-09 | 2001-09-11 | Schneider (Usa) Inc. | Method for reducing dilation balloon cone stiffness |
WO2000038574A1 (en) | 1998-12-23 | 2000-07-06 | Nuvasive, Inc. | Nerve surveillance cannulae systems |
US6312405B1 (en) | 1999-02-02 | 2001-11-06 | American Medical Systems, Inc. | Self-sealing detachable balloon |
US6767353B1 (en) | 2002-03-01 | 2004-07-27 | Samuel Shiber | Thrombectomy catheter |
US9814869B1 (en) | 1999-06-15 | 2017-11-14 | C.R. Bard, Inc. | Graft-catheter vascular access system |
US6500285B2 (en) | 1999-08-23 | 2002-12-31 | Scimed Life Systems, Inc. | Method of making a catheter having interlocking ribbed bond regions |
US6322541B2 (en) | 1999-09-10 | 2001-11-27 | Scimed Life Systems, Inc. | Vascular introducer sheath and hemostasis valve for use therewith |
US20090093791A1 (en) * | 1999-09-17 | 2009-04-09 | Heuser Richard R | Devices and methods for treating chronic total occlusion |
US20040097996A1 (en) | 1999-10-05 | 2004-05-20 | Omnisonics Medical Technologies, Inc. | Apparatus and method of removing occlusions using an ultrasonic medical device operating in a transverse mode |
JP4854900B2 (en) | 1999-11-24 | 2012-01-18 | ヌバシブ, インコーポレイテッド | EMG measurement method |
US6206852B1 (en) * | 1999-12-15 | 2001-03-27 | Advanced Cardiovascular Systems, Inc. | Balloon catheter having a small profile catheter |
US7118551B1 (en) * | 1999-12-22 | 2006-10-10 | Advanced Cardiovascular Systems, Inc. | Non-metal reinforcing mandrel |
US6575959B1 (en) | 1999-12-27 | 2003-06-10 | Scimed Life Systems, Inc. | Catheter incorporating an insert molded hub and method of manufacturing |
US6547766B1 (en) * | 2000-05-11 | 2003-04-15 | Advanced Cardiovascular Systems, Inc. | Catheter with variable dimension guide wire lumen |
US6673302B2 (en) * | 2001-01-24 | 2004-01-06 | Scimed Life Systems, Inc. | Wet processing method for catheter balloons |
US6520939B2 (en) | 2001-02-13 | 2003-02-18 | Scimed Life Systems, Inc. | Hemostasis valve |
US6979343B2 (en) * | 2001-02-14 | 2005-12-27 | Ev3 Inc. | Rolled tip recovery catheter |
US6666847B2 (en) * | 2001-05-18 | 2003-12-23 | Us Endoscopy Group, Inc. | Duodenoscope needle |
ATE347393T1 (en) * | 2001-07-05 | 2006-12-15 | Precision Vascular Systems Inc | MEDICAL DEVICE HAVING A TORQUE-TRANSMITTING SOFT END PIECE AND METHOD FOR SHAPING IT |
EP1417000B1 (en) | 2001-07-11 | 2018-07-11 | Nuvasive, Inc. | System for determining nerve proximity during surgery |
US6776774B2 (en) | 2001-07-16 | 2004-08-17 | Scimed Life Systems, Inc. | Hemostasis gasket valve |
WO2003026482A2 (en) | 2001-09-25 | 2003-04-03 | Nuvasive, Inc. | System and methods for performing surgical procedures and assessments |
JP2003169806A (en) * | 2001-12-05 | 2003-06-17 | Olympus Optical Co Ltd | Ultrasonic probe |
US6908459B2 (en) | 2001-12-07 | 2005-06-21 | Becton, Dickinson And Company | Needleless luer access connector |
US7065394B2 (en) * | 2001-12-12 | 2006-06-20 | Medtronic, Inc | Guide catheter |
US20040073158A1 (en) * | 2001-12-12 | 2004-04-15 | Medtronic, Inc. | Guide catheter |
US9017308B2 (en) | 2002-05-21 | 2015-04-28 | Boston Scientific Scimed, Inc. | Insert molded hub and strain relief |
US7582058B1 (en) | 2002-06-26 | 2009-09-01 | Nuvasive, Inc. | Surgical access system and related methods |
US7914467B2 (en) * | 2002-07-25 | 2011-03-29 | Boston Scientific Scimed, Inc. | Tubular member having tapered transition for use in a medical device |
EP1545680B1 (en) * | 2002-07-25 | 2010-09-08 | Boston Scientific Limited | Medical device for navigation through anatomy |
US7186222B1 (en) | 2002-09-10 | 2007-03-06 | Radiant Medical, Inc. | Vascular introducer with temperature monitoring probe and systems for endovascular temperature control |
US8137284B2 (en) | 2002-10-08 | 2012-03-20 | Nuvasive, Inc. | Surgical access system and related methods |
US7300459B2 (en) * | 2002-10-17 | 2007-11-27 | Heuser Richard R | Stent with covering and differential dilation |
US7691057B2 (en) | 2003-01-16 | 2010-04-06 | Nuvasive, Inc. | Surgical access system and related methods |
US8377035B2 (en) | 2003-01-17 | 2013-02-19 | Boston Scientific Scimed, Inc. | Unbalanced reinforcement members for medical device |
US7166088B2 (en) * | 2003-01-27 | 2007-01-23 | Heuser Richard R | Catheter introducer system |
US20040167437A1 (en) * | 2003-02-26 | 2004-08-26 | Sharrow James S. | Articulating intracorporal medical device |
US7169118B2 (en) | 2003-02-26 | 2007-01-30 | Scimed Life Systems, Inc. | Elongate medical device with distal cap |
US7819801B2 (en) | 2003-02-27 | 2010-10-26 | Nuvasive, Inc. | Surgical access system and related methods |
US7001369B2 (en) * | 2003-03-27 | 2006-02-21 | Scimed Life Systems, Inc. | Medical device |
JP2007525242A (en) | 2003-04-25 | 2007-09-06 | タイコ ヘルスケア グループ エルピー | Surgical access device |
US7359755B2 (en) | 2003-08-08 | 2008-04-15 | Advanced Neuromodulation Systems, Inc. | Method and apparatus for implanting an electrical stimulation lead using a flexible introducer |
US7402141B2 (en) | 2003-08-27 | 2008-07-22 | Heuser Richard R | Catheter guidewire system using concentric wires |
US7630747B2 (en) * | 2003-09-09 | 2009-12-08 | Keimar, Inc. | Apparatus for ascertaining blood characteristics and probe for use therewith |
WO2005030318A1 (en) | 2003-09-25 | 2005-04-07 | Nuvasive, Inc. | Surgical access system and related methods |
US7905840B2 (en) | 2003-10-17 | 2011-03-15 | Nuvasive, Inc. | Surgical access system and related methods |
US7226434B2 (en) | 2003-10-31 | 2007-06-05 | Tyco Healthcare Group Lp | Safety shield |
US7988664B2 (en) | 2004-11-01 | 2011-08-02 | Tyco Healthcare Group Lp | Locking clip with trigger bushing |
US7824345B2 (en) | 2003-12-22 | 2010-11-02 | Boston Scientific Scimed, Inc. | Medical device with push force limiter |
US7794414B2 (en) | 2004-02-09 | 2010-09-14 | Emigrant Bank, N.A. | Apparatus and method for an ultrasonic medical device operating in torsional and transverse modes |
US20050234426A1 (en) * | 2004-04-14 | 2005-10-20 | Scimed Life Systems, Inc. | Catheter distal tip design and method of making |
US20050234499A1 (en) * | 2004-04-19 | 2005-10-20 | Scimed Life Systems, Inc. | Multi-lumen balloon catheter including manifold |
US7662144B2 (en) | 2004-06-22 | 2010-02-16 | Boston Scientific Scimed, Inc. | Catheter shaft with improved manifold bond |
US20080154153A1 (en) * | 2004-08-25 | 2008-06-26 | Heuser Richard R | Multiple-wire systems and methods for ablation of occlusions within blood vessels |
US8545418B2 (en) * | 2004-08-25 | 2013-10-01 | Richard R. Heuser | Systems and methods for ablation of occlusions within blood vessels |
US7505881B2 (en) * | 2004-09-11 | 2009-03-17 | The Board Of Trustees Of The Leland Stanford Junior University | Method and apparatus for modeling the modal properties of optical waveguides |
WO2006042241A2 (en) | 2004-10-08 | 2006-04-20 | Nuvasive, Inc. | Surgical access system and related methods |
US7632242B2 (en) | 2004-12-09 | 2009-12-15 | Boston Scientific Scimed, Inc. | Catheter including a compliant balloon |
US20060129221A1 (en) * | 2004-12-10 | 2006-06-15 | Medtronic, Inc. | Tunneling guide |
US7815599B2 (en) | 2004-12-10 | 2010-10-19 | Boston Scientific Scimed, Inc. | Catheter having an ultra soft tip and methods for making the same |
US20060178698A1 (en) * | 2005-02-08 | 2006-08-10 | Mcintyre Jon T | Method and device for canulation and occlusion of uterine arteries |
US20060264904A1 (en) * | 2005-05-09 | 2006-11-23 | Kerby Walter L | Medical device |
US8801744B2 (en) * | 2006-06-28 | 2014-08-12 | Abbott Laboratories | Expandable introducer sheath to preserve guidewire access |
US9597063B2 (en) * | 2006-06-28 | 2017-03-21 | Abbott Laboratories | Expandable introducer sheath to preserve guidewire access |
US8440122B2 (en) | 2005-06-30 | 2013-05-14 | Abbott Vascular Inc. | Introducer sheath and methods of making |
US9168359B2 (en) | 2005-06-30 | 2015-10-27 | Abbott Laboratories | Modular introducer and exchange sheath |
US8359723B2 (en) * | 2005-06-30 | 2013-01-29 | Abbott Vascular Inc. | Introducer sheath and methods of making |
US20100130937A1 (en) * | 2005-06-30 | 2010-05-27 | Abbott Vascular Inc. | Introducer sheath and methods of making |
US20080051717A1 (en) * | 2006-06-28 | 2008-02-28 | Abbott Laboratories | Introducer sheath |
US20080004571A1 (en) * | 2006-06-28 | 2008-01-03 | Abbott Laboratories | Expandable introducer sheath |
US9352118B2 (en) | 2005-06-30 | 2016-05-31 | Abbott Laboratories | Modular introducer and exchange sheath |
US9445784B2 (en) * | 2005-09-22 | 2016-09-20 | Boston Scientific Scimed, Inc | Intravascular ultrasound catheter |
US7850623B2 (en) | 2005-10-27 | 2010-12-14 | Boston Scientific Scimed, Inc. | Elongate medical device with continuous reinforcement member |
US20070106228A1 (en) * | 2005-11-09 | 2007-05-10 | David Bell | Flexible valve for blood treatment set |
US20070203572A1 (en) * | 2006-01-25 | 2007-08-30 | Heuser Richard R | Catheter system with stent apparatus for connecting adjacent blood vessels |
US8062321B2 (en) * | 2006-01-25 | 2011-11-22 | Pq Bypass, Inc. | Catheter system for connecting adjacent blood vessels |
US20070203515A1 (en) * | 2006-01-25 | 2007-08-30 | Heuser Richard R | Catheter system for connecting adjacent blood vessels |
US7374567B2 (en) * | 2006-01-25 | 2008-05-20 | Heuser Richard R | Catheter system for connecting adjacent blood vessels |
US9289232B2 (en) * | 2006-05-05 | 2016-03-22 | Avent, Inc. | Soft tissue tunneling device |
US8672889B2 (en) | 2006-05-05 | 2014-03-18 | Kimberly-Clark Worldwide, Inc. | Soft tissue tunneling device |
US9889275B2 (en) | 2006-06-28 | 2018-02-13 | Abbott Laboratories | Expandable introducer sheath to preserve guidewire access |
US20100198160A1 (en) * | 2006-06-28 | 2010-08-05 | Abbott Vascular Inc. | Expandable Introducer Sheaths and Methods for Manufacture and Use |
US8403196B2 (en) * | 2006-09-08 | 2013-03-26 | Covidien Lp | Dissection tip and introducer for surgical instrument |
JP2010503484A (en) * | 2006-09-13 | 2010-02-04 | ボストン サイエンティフィック リミテッド | Transverse guide wire |
JP4994775B2 (en) | 2006-10-12 | 2012-08-08 | 日本コヴィディエン株式会社 | Needle point protector |
EP2476384B1 (en) | 2006-11-22 | 2015-11-04 | Applied Medical Resources Corporation | Trocar cannula with atraumatic tip |
US8556914B2 (en) * | 2006-12-15 | 2013-10-15 | Boston Scientific Scimed, Inc. | Medical device including structure for crossing an occlusion in a vessel |
US20080177249A1 (en) * | 2007-01-22 | 2008-07-24 | Heuser Richard R | Catheter introducer system |
US20080234813A1 (en) * | 2007-03-20 | 2008-09-25 | Heuser Richard R | Percutaneous Interventional Cardiology System for Treating Valvular Disease |
US7815608B2 (en) * | 2007-04-02 | 2010-10-19 | William Cook Australia Pty. Ltd. | High flex introducer assembly |
US20080262474A1 (en) * | 2007-04-20 | 2008-10-23 | Boston Scientific Scimed, Inc. | Medical device |
US20080289658A1 (en) * | 2007-05-21 | 2008-11-27 | Eli Bradley A | Human-interface cleaning device and cleaning method |
US8372215B2 (en) * | 2007-05-21 | 2013-02-12 | Bradley A. Eli | Human-interface cleaning device |
WO2009003044A1 (en) | 2007-06-26 | 2008-12-31 | Avalon Laboratories, Llc | Coaxial venal cannula |
US8409114B2 (en) * | 2007-08-02 | 2013-04-02 | Boston Scientific Scimed, Inc. | Composite elongate medical device including distal tubular member |
US8105246B2 (en) * | 2007-08-03 | 2012-01-31 | Boston Scientific Scimed, Inc. | Elongate medical device having enhanced torque and methods thereof |
US20090036832A1 (en) * | 2007-08-03 | 2009-02-05 | Boston Scientific Scimed, Inc. | Guidewires and methods for manufacturing guidewires |
US20090043228A1 (en) * | 2007-08-06 | 2009-02-12 | Boston Scientific Scimed, Inc. | Laser shock peening of medical devices |
US8821477B2 (en) * | 2007-08-06 | 2014-09-02 | Boston Scientific Scimed, Inc. | Alternative micromachined structures |
US9808595B2 (en) * | 2007-08-07 | 2017-11-07 | Boston Scientific Scimed, Inc | Microfabricated catheter with improved bonding structure |
WO2009029332A1 (en) * | 2007-08-27 | 2009-03-05 | Avalon Laboratories, Llc | Introducer for cannula and method |
WO2009042874A1 (en) | 2007-09-27 | 2009-04-02 | Tyco Healthcare Group Lp | I.v. catheter assembly and needle safety device |
US7841994B2 (en) | 2007-11-02 | 2010-11-30 | Boston Scientific Scimed, Inc. | Medical device for crossing an occlusion in a vessel |
US8858608B2 (en) * | 2007-12-10 | 2014-10-14 | Cook Medical Technologies Llc | Lubrication apparatus for a delivery and deployment device |
ATE482738T1 (en) | 2007-12-20 | 2010-10-15 | Tyco Healthcare | CAP ASSEMBLY WITH SPRING-LOADED CUFF |
WO2009086505A2 (en) * | 2007-12-27 | 2009-07-09 | University Of South Florida | Multichannel trocar |
CA2901300A1 (en) | 2008-01-14 | 2009-07-23 | I-V Access Technology, Inc. | An apparatus for peripheral vascular access |
US20090192485A1 (en) * | 2008-01-28 | 2009-07-30 | Heuser Richard R | Snare device |
US8376961B2 (en) | 2008-04-07 | 2013-02-19 | Boston Scientific Scimed, Inc. | Micromachined composite guidewire structure with anisotropic bending properties |
US20100010328A1 (en) * | 2008-07-11 | 2010-01-14 | Nguyen Harry D | Probes and sensors for ascertaining blood characteristics and methods and devices for use therewith |
US20100057046A1 (en) * | 2008-09-03 | 2010-03-04 | Keimar, Inc | Systems for characterizing physiologic parameters and methods for use therewith |
US20100057048A1 (en) * | 2008-09-04 | 2010-03-04 | Stephen Eldredge | Apparatus, System, and Method for Treating Atypical Headaches |
US20100063479A1 (en) * | 2008-09-10 | 2010-03-11 | Boston Scientific Scimed, Inc. | Small profile, tubular component design and method of manufacture |
US8535243B2 (en) * | 2008-09-10 | 2013-09-17 | Boston Scientific Scimed, Inc. | Medical devices and tapered tubular members for use in medical devices |
US8795254B2 (en) * | 2008-12-10 | 2014-08-05 | Boston Scientific Scimed, Inc. | Medical devices with a slotted tubular member having improved stress distribution |
AU2009329873A1 (en) | 2008-12-26 | 2011-11-03 | Scott Spann | Minimally-invasive retroperitoneal lateral approach for spinal surgery |
US8469928B2 (en) * | 2009-02-11 | 2013-06-25 | Becton, Dickinson And Company | Systems and methods for providing a flushable catheter assembly |
US8388583B2 (en) * | 2009-08-20 | 2013-03-05 | Becton, Dickinson And Company | Systems and methods for providing a flushable catheter assembly |
US8361038B2 (en) | 2009-02-11 | 2013-01-29 | Becton, Dickinson And Company | Systems and methods for providing a flow control valve for a medical device |
US8574203B2 (en) | 2009-02-11 | 2013-11-05 | Becton, Dickinson And Company | Systems and methods for providing a flushable catheter assembly |
US20100300451A1 (en) * | 2009-06-01 | 2010-12-02 | Griffith Nathan C | Punch Dilator |
US9205244B2 (en) | 2009-06-29 | 2015-12-08 | Cook Medical Technologies Llc | Haemostatic valve device |
US20110112375A1 (en) * | 2009-11-12 | 2011-05-12 | Tyco Healthcare Group Lp | Portal apparatus including conformable cup seal |
US8137293B2 (en) | 2009-11-17 | 2012-03-20 | Boston Scientific Scimed, Inc. | Guidewires including a porous nickel-titanium alloy |
WO2011123689A1 (en) | 2010-03-31 | 2011-10-06 | Boston Scientific Scimed, Inc. | Guidewire with a flexural rigidity profile |
US8361020B2 (en) | 2010-07-15 | 2013-01-29 | Becton, Dickinson And Company | Catheter assembly and pierced septum valve |
US8932259B2 (en) | 2010-09-13 | 2015-01-13 | Becton, Dickinson And Company | Catheter assembly |
US8262619B2 (en) | 2010-09-30 | 2012-09-11 | Tyco Healthcare Group Lp | Introducer sheath for catheters |
WO2012106628A1 (en) | 2011-02-04 | 2012-08-09 | Boston Scientific Scimed, Inc. | Guidewires and methods for making and using the same |
US8790406B1 (en) | 2011-04-01 | 2014-07-29 | William D. Smith | Systems and methods for performing spine surgery |
US8486024B2 (en) | 2011-04-27 | 2013-07-16 | Covidien Lp | Safety IV catheter assemblies |
US9072874B2 (en) | 2011-05-13 | 2015-07-07 | Boston Scientific Scimed, Inc. | Medical devices with a heat transfer region and a heat sink region and methods for manufacturing medical devices |
WO2013028571A1 (en) | 2011-08-19 | 2013-02-28 | Lanx, Inc. | Surgical retractor system and methods of use |
EP2760520A1 (en) | 2011-09-26 | 2014-08-06 | Covidien LP | Safety catheter |
WO2013048768A1 (en) | 2011-09-26 | 2013-04-04 | Covidien Lp | Safety iv catheter and needle assembly |
US9155863B2 (en) | 2011-10-06 | 2015-10-13 | Becton, Dickinson And Company | Multiple use stretching and non-penetrating blood control valves |
US9358364B2 (en) | 2011-10-06 | 2016-06-07 | Becton, Dickinson And Company | Activator attachment for blood control catheters |
US9126012B2 (en) | 2011-10-06 | 2015-09-08 | Becton, Dickinson And Company | Intravenous catheter with duckbill valve |
US9155876B2 (en) | 2011-10-06 | 2015-10-13 | Becton, Dickinson And Company | Port valve of a blood control catheter |
US9089671B2 (en) | 2011-10-06 | 2015-07-28 | Becton, Dickinson And Company | Systems and methods for sealing a septum within a catheter device |
US9155864B2 (en) | 2011-10-06 | 2015-10-13 | Becton, Dickinson And Company | Multiple use blood control valve with center and circumferential slits |
US8834422B2 (en) | 2011-10-14 | 2014-09-16 | Covidien Lp | Vascular access assembly and safety device |
WO2013059204A1 (en) | 2011-10-21 | 2013-04-25 | Boston Scientific Scimed, Inc. | Locking catheter hub |
US9198765B1 (en) | 2011-10-31 | 2015-12-01 | Nuvasive, Inc. | Expandable spinal fusion implants and related methods |
US9579486B2 (en) | 2012-08-22 | 2017-02-28 | Becton, Dickinson And Company | Blood control IV catheter with antimicrobial properties |
WO2014107600A1 (en) * | 2013-01-03 | 2014-07-10 | Summit Access, LLC | Composite wires for use in medical procedures and associated methods |
US9695323B2 (en) | 2013-02-13 | 2017-07-04 | Becton, Dickinson And Company | UV curable solventless antimicrobial compositions |
US9750928B2 (en) | 2013-02-13 | 2017-09-05 | Becton, Dickinson And Company | Blood control IV catheter with stationary septum activator |
US10098734B2 (en) * | 2013-12-05 | 2018-10-16 | Edwards Lifesciences Corporation | Prosthetic heart valve and delivery apparatus |
EP2884767A1 (en) * | 2013-12-16 | 2015-06-17 | Oticon Medical A/S | Device for installing an implant for a bone anchored hearing aid |
US9750925B2 (en) | 2014-01-21 | 2017-09-05 | Becton, Dickinson And Company | Ported catheter adapter having combined port and blood control valve with venting |
US9901706B2 (en) | 2014-04-11 | 2018-02-27 | Boston Scientific Scimed, Inc. | Catheters and catheter shafts |
US9675793B2 (en) | 2014-04-23 | 2017-06-13 | Becton, Dickinson And Company | Catheter tubing with extraluminal antimicrobial coating |
US9789279B2 (en) | 2014-04-23 | 2017-10-17 | Becton, Dickinson And Company | Antimicrobial obturator for use with vascular access devices |
US10376686B2 (en) | 2014-04-23 | 2019-08-13 | Becton, Dickinson And Company | Antimicrobial caps for medical connectors |
US10232088B2 (en) | 2014-07-08 | 2019-03-19 | Becton, Dickinson And Company | Antimicrobial coating forming kink resistant feature on a vascular access device |
US9808598B2 (en) | 2015-02-04 | 2017-11-07 | Teleflex Medical Incorporated | Flexible tip dilator |
US10525237B2 (en) | 2015-10-28 | 2020-01-07 | Becton, Dickinson And Company | Ergonomic IV systems and methods |
US10814106B2 (en) | 2015-10-28 | 2020-10-27 | Becton, Dickinson And Company | Soft push tabs for catheter adapter |
US10639455B2 (en) | 2015-10-28 | 2020-05-05 | Becton, Dickinson And Company | Closed IV access device with paddle grip needle hub and flash chamber |
US10493244B2 (en) | 2015-10-28 | 2019-12-03 | Becton, Dickinson And Company | Extension tubing strain relief |
US10245416B2 (en) | 2015-10-28 | 2019-04-02 | Becton, Dickinson And Company | Intravenous catheter device with integrated extension tube |
US10357636B2 (en) | 2015-10-28 | 2019-07-23 | Becton, Dickinson And Company | IV access device having an angled paddle grip |
US10549072B2 (en) | 2015-10-28 | 2020-02-04 | Becton, Dickinson And Company | Integrated catheter with independent fluid paths |
US10744305B2 (en) | 2015-10-28 | 2020-08-18 | Becton, Dickinson And Company | Ergonomic IV systems and methods |
US11351048B2 (en) | 2015-11-16 | 2022-06-07 | Boston Scientific Scimed, Inc. | Stent delivery systems with a reinforced deployment sheath |
EP3463158B1 (en) * | 2016-05-26 | 2023-08-30 | Covidien LP | Cannula assemblies for use with robotic surgical systems |
USD835262S1 (en) | 2016-10-05 | 2018-12-04 | Becton, Dickinson And Company | Intravenous catheter assembly |
US10238852B2 (en) | 2016-10-05 | 2019-03-26 | Becton, Dickinson And Company | Septum housing |
USD844781S1 (en) | 2016-10-05 | 2019-04-02 | Becton, Dickinson And Company | Needle hub |
USD819802S1 (en) | 2016-10-05 | 2018-06-05 | Becton, Dickinson And Company | Catheter adapter |
USD837368S1 (en) | 2016-10-05 | 2019-01-01 | Becton, Dickinson And Company | Catheter adapter grip |
US10758719B2 (en) * | 2016-12-15 | 2020-09-01 | Surmodics, Inc. | Low-friction sealing devices |
JP6972108B2 (en) * | 2017-03-23 | 2021-11-24 | テルモ株式会社 | Catheter assembly |
US11324939B2 (en) | 2017-08-31 | 2022-05-10 | I-V Access Technology, Inc. | Methods and devices for vascular access |
US10406326B2 (en) | 2017-08-31 | 2019-09-10 | I-V Access Technology, Inc. | Methods and devices for vascular access |
CN112401971A (en) * | 2019-08-23 | 2021-02-26 | 贝克顿·迪金森公司 | Kit designed for percutaneous nephrolithotomy surgery |
US11318286B2 (en) | 2020-03-23 | 2022-05-03 | I-V Access Technology, Inc. | Catheter needle assembly with enclosable needle |
US11607525B1 (en) * | 2022-06-30 | 2023-03-21 | I-V Access Technology, Inc. | Methods and devices for vascular access |
Citations (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE2140755A1 (en) * | 1971-08-13 | 1973-02-22 | Sherwood Medical Ind Inc | PLASTIC HOSE |
EP0051718A1 (en) * | 1980-11-08 | 1982-05-19 | Intermedicat Gmbh | Entering device for catheters |
DE3532560A1 (en) * | 1984-09-13 | 1986-03-20 | Olympus Optical Co., Ltd., Tokio/Tokyo | LOCKING DEVICE FOR THE MOUTHPIECE OF AN ENDOSCOPE |
US4657772A (en) * | 1985-05-13 | 1987-04-14 | Nuri Kocak | Introducer sheath assembly |
EP0232994A2 (en) * | 1986-02-04 | 1987-08-19 | Sherwood Medical Company | Catheter introducer |
GB2190387A (en) * | 1986-05-15 | 1987-11-18 | Yarsley Technical Centre Limit | Hydrophilic copolymers for wound dressings and other biomedical uses |
Family Cites Families (15)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4119095A (en) * | 1977-05-19 | 1978-10-10 | Mattie Lewis | Restraining garment |
US4119094A (en) * | 1977-08-08 | 1978-10-10 | Biosearch Medical Products Inc. | Coated substrate having a low coefficient of friction hydrophilic coating and a method of making the same |
US4100309A (en) * | 1977-08-08 | 1978-07-11 | Biosearch Medical Products, Inc. | Coated substrate having a low coefficient of friction hydrophilic coating and a method of making the same |
SE430695B (en) * | 1982-04-22 | 1983-12-05 | Astra Meditec Ab | PROCEDURE FOR THE PREPARATION OF A HYDROPHILIC COATING AND ACCORDING TO THE PROCEDURE OF MEDICAL ARTICLES |
US4610665A (en) * | 1983-01-18 | 1986-09-09 | Terumo Kabushiki Kaisha | Medical instrument |
US4563181A (en) * | 1983-02-18 | 1986-01-07 | Mallinckrodt, Inc. | Fused flexible tip catheter |
DE3323190A1 (en) * | 1983-06-28 | 1985-01-10 | Michael Hörauf Maschinenfabrik GmbH & Co KG, 7334 Süssen | DEVICE FOR PRODUCING PAPER CONTAINERS |
JPS60126170A (en) * | 1983-12-14 | 1985-07-05 | テルモ株式会社 | Catheter and its production |
US4636346A (en) * | 1984-03-08 | 1987-01-13 | Cordis Corporation | Preparing guiding catheter |
JPS60234671A (en) * | 1984-05-09 | 1985-11-21 | テルモ株式会社 | Catheter inserter |
US4569347A (en) * | 1984-05-30 | 1986-02-11 | Advanced Cardiovascular Systems, Inc. | Catheter introducing device, assembly and method |
US4588398A (en) * | 1984-09-12 | 1986-05-13 | Warner-Lambert Company | Catheter tip configuration |
JPS6171065A (en) * | 1984-09-13 | 1986-04-11 | テルモ株式会社 | Catheter introducer |
US4668225A (en) * | 1985-12-23 | 1987-05-26 | Superior Healthcare Group, Inc. | Gastrostomy tube and gastrostomy-jejunal feeding tube combination |
US4950257A (en) * | 1988-09-15 | 1990-08-21 | Mallinckrodt, Inc. | Catheter introducer with flexible tip |
-
1988
- 1988-09-15 US US07/244,290 patent/US4950257A/en not_active Expired - Fee Related
-
1989
- 1989-07-19 WO PCT/US1989/003266 patent/WO1990002579A2/en unknown
- 1989-07-19 AU AU40564/89A patent/AU4056489A/en not_active Abandoned
- 1989-07-20 CA CA000606275A patent/CA1322920C/en not_active Expired - Fee Related
-
1990
- 1990-06-12 US US07/536,851 patent/US5300032A/en not_active Expired - Fee Related
Patent Citations (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE2140755A1 (en) * | 1971-08-13 | 1973-02-22 | Sherwood Medical Ind Inc | PLASTIC HOSE |
EP0051718A1 (en) * | 1980-11-08 | 1982-05-19 | Intermedicat Gmbh | Entering device for catheters |
DE3532560A1 (en) * | 1984-09-13 | 1986-03-20 | Olympus Optical Co., Ltd., Tokio/Tokyo | LOCKING DEVICE FOR THE MOUTHPIECE OF AN ENDOSCOPE |
US4657772A (en) * | 1985-05-13 | 1987-04-14 | Nuri Kocak | Introducer sheath assembly |
EP0232994A2 (en) * | 1986-02-04 | 1987-08-19 | Sherwood Medical Company | Catheter introducer |
GB2190387A (en) * | 1986-05-15 | 1987-11-18 | Yarsley Technical Centre Limit | Hydrophilic copolymers for wound dressings and other biomedical uses |
Cited By (16)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0450221A1 (en) * | 1990-04-04 | 1991-10-09 | C.R. Bard, Inc. | Expandable soft tip sheath |
EP0499401A1 (en) * | 1991-02-14 | 1992-08-19 | Smiths Industries Plc | Resealable sampling port |
FR2694181A1 (en) * | 1992-07-31 | 1994-02-04 | Medecine Sa Ste Europ | Trocar sleeve for endoscopic examination and surgery of the body cavities. |
WO1994003116A1 (en) * | 1992-07-31 | 1994-02-17 | Europeenne De Medecine S.A. | Trocar sleeve with valve |
EP0596172A2 (en) * | 1992-11-03 | 1994-05-11 | Robert E. Fischell | Radiopaque non-kinking thin-walled introducer sheath |
EP0596172A3 (en) * | 1992-11-03 | 1995-02-15 | Fischell Robert | Radiopaque non-kinking thin-walled introducer sheath. |
EP0624380A1 (en) * | 1993-05-12 | 1994-11-17 | Cook Incorporated | Radiopaque catheter |
US5599325A (en) * | 1994-05-18 | 1997-02-04 | Schneider (Usa) Inc | Thin wall catheter with reinforcing sleeve |
WO1995031226A1 (en) * | 1994-05-18 | 1995-11-23 | Schneider (Usa) Inc. | Thin wall catheter having enhanced torqueability characteristics |
US5725513A (en) * | 1994-05-18 | 1998-03-10 | Schneider (Usa) Inc | Thin wall catheter with reinforcing sleeve |
WO1996004952A1 (en) * | 1994-08-08 | 1996-02-22 | Schneider (Usa) Inc. | Drug delivery and dilatation-drug delivery catheters in a rapid exchange configuration |
US5514092A (en) * | 1994-08-08 | 1996-05-07 | Schneider (Usa) Inc. | Drug delivery and dilatation-drug delivery catheters in a rapid exchange configuration |
EP0723787A3 (en) * | 1995-01-25 | 1996-08-07 | Cordis Europa N.V. | Haemostatic device |
NL9500142A (en) * | 1995-01-25 | 1996-09-02 | Cordis Europ | Hemostasis device. |
EP0723787A2 (en) * | 1995-01-25 | 1996-07-31 | Cordis Europa N.V. | Haemostatic device |
WO2000012167A1 (en) * | 1998-08-26 | 2000-03-09 | Microcatheters Pty. Ltd. | Catheter guide |
Also Published As
Publication number | Publication date |
---|---|
AU4056489A (en) | 1990-04-02 |
US4950257A (en) | 1990-08-21 |
CA1322920C (en) | 1993-10-12 |
US5300032A (en) | 1994-04-05 |
WO1990002579A3 (en) | 1990-10-18 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
US4950257A (en) | Catheter introducer with flexible tip | |
EP0570530B1 (en) | Catheter with changeable number of lumens | |
US5853394A (en) | Catheter | |
US5209741A (en) | Surgical access device having variable post-insertion cross-sectional geometry | |
US5538505A (en) | Hemostasis valve for catheter introducer having thickened central partition section | |
EP1631343B1 (en) | Flexible introducer sheath with varying durometer | |
EP1819390B1 (en) | Introducer apparatus | |
US5085649A (en) | Torque controlled tubing | |
US6544247B1 (en) | Introducer system | |
EP0771573B1 (en) | Kink resistant catheter sheath introducer | |
US7311697B2 (en) | Central venous catheter | |
EP2217314B1 (en) | Drainage catheter | |
EP0787504A2 (en) | Catheter | |
US20080097397A1 (en) | Vascular introducer sheath | |
EP0450221A1 (en) | Expandable soft tip sheath | |
JP4280526B2 (en) | Medical instruments | |
US20050038411A1 (en) | Catheter | |
JP2002291902A (en) | Medical instrument insertion tool | |
JP4316252B2 (en) | catheter | |
JP4311845B2 (en) | Medical introducer | |
JPS6122987B2 (en) | ||
JP2002291868A (en) | Thrombus aspirator |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
AK | Designated states |
Kind code of ref document: A2 Designated state(s): AU JP |
|
AL | Designated countries for regional patents |
Kind code of ref document: A2 Designated state(s): AT BE CH DE FR GB IT LU NL SE |
|
AK | Designated states |
Kind code of ref document: A3 Designated state(s): AU JP |
|
AL | Designated countries for regional patents |
Kind code of ref document: A3 Designated state(s): AT BE CH DE FR GB IT LU NL SE |