WO1990007380A3 - Methods and materials for high gradient magnetic separation of biological materials - Google Patents

Methods and materials for high gradient magnetic separation of biological materials Download PDF

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Publication number
WO1990007380A3
WO1990007380A3 PCT/EP1989/001602 EP8901602W WO9007380A3 WO 1990007380 A3 WO1990007380 A3 WO 1990007380A3 EP 8901602 W EP8901602 W EP 8901602W WO 9007380 A3 WO9007380 A3 WO 9007380A3
Authority
WO
WIPO (PCT)
Prior art keywords
materials
methods
magnetic separation
gradient magnetic
high gradient
Prior art date
Application number
PCT/EP1989/001602
Other languages
French (fr)
Other versions
WO1990007380A2 (en
Inventor
Stefan Miltenyi
Original Assignee
Stefan Miltenyi
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Stefan Miltenyi filed Critical Stefan Miltenyi
Priority to DE68919715T priority Critical patent/DE68919715T2/en
Priority to EP90900152A priority patent/EP0452342B1/en
Publication of WO1990007380A2 publication Critical patent/WO1990007380A2/en
Publication of WO1990007380A3 publication Critical patent/WO1990007380A3/en

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G01N33/54313—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals the carrier being characterised by its particulate form
    • G01N33/54326—Magnetic particles
    • G01N33/5434—Magnetic particles using magnetic particle immunoreagent carriers which constitute new materials per se
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B03—SEPARATION OF SOLID MATERIALS USING LIQUIDS OR USING PNEUMATIC TABLES OR JIGS; MAGNETIC OR ELECTROSTATIC SEPARATION OF SOLID MATERIALS FROM SOLID MATERIALS OR FLUIDS; SEPARATION BY HIGH-VOLTAGE ELECTRIC FIELDS
    • B03C—MAGNETIC OR ELECTROSTATIC SEPARATION OF SOLID MATERIALS FROM SOLID MATERIALS OR FLUIDS; SEPARATION BY HIGH-VOLTAGE ELECTRIC FIELDS
    • B03C1/00—Magnetic separation
    • B03C1/002—High gradient magnetic separation
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B03—SEPARATION OF SOLID MATERIALS USING LIQUIDS OR USING PNEUMATIC TABLES OR JIGS; MAGNETIC OR ELECTROSTATIC SEPARATION OF SOLID MATERIALS FROM SOLID MATERIALS OR FLUIDS; SEPARATION BY HIGH-VOLTAGE ELECTRIC FIELDS
    • B03C—MAGNETIC OR ELECTROSTATIC SEPARATION OF SOLID MATERIALS FROM SOLID MATERIALS OR FLUIDS; SEPARATION BY HIGH-VOLTAGE ELECTRIC FIELDS
    • B03C1/00—Magnetic separation
    • B03C1/005—Pretreatment specially adapted for magnetic separation
    • B03C1/01—Pretreatment specially adapted for magnetic separation by addition of magnetic adjuvants
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B03—SEPARATION OF SOLID MATERIALS USING LIQUIDS OR USING PNEUMATIC TABLES OR JIGS; MAGNETIC OR ELECTROSTATIC SEPARATION OF SOLID MATERIALS FROM SOLID MATERIALS OR FLUIDS; SEPARATION BY HIGH-VOLTAGE ELECTRIC FIELDS
    • B03C—MAGNETIC OR ELECTROSTATIC SEPARATION OF SOLID MATERIALS FROM SOLID MATERIALS OR FLUIDS; SEPARATION BY HIGH-VOLTAGE ELECTRIC FIELDS
    • B03C1/00—Magnetic separation
    • B03C1/02—Magnetic separation acting directly on the substance being separated
    • B03C1/025—High gradient magnetic separators
    • B03C1/031—Component parts; Auxiliary operations
    • B03C1/033—Component parts; Auxiliary operations characterised by the magnetic circuit
    • B03C1/0332—Component parts; Auxiliary operations characterised by the magnetic circuit using permanent magnets
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B03—SEPARATION OF SOLID MATERIALS USING LIQUIDS OR USING PNEUMATIC TABLES OR JIGS; MAGNETIC OR ELECTROSTATIC SEPARATION OF SOLID MATERIALS FROM SOLID MATERIALS OR FLUIDS; SEPARATION BY HIGH-VOLTAGE ELECTRIC FIELDS
    • B03C—MAGNETIC OR ELECTROSTATIC SEPARATION OF SOLID MATERIALS FROM SOLID MATERIALS OR FLUIDS; SEPARATION BY HIGH-VOLTAGE ELECTRIC FIELDS
    • B03C1/00—Magnetic separation
    • B03C1/02—Magnetic separation acting directly on the substance being separated
    • B03C1/025—High gradient magnetic separators
    • B03C1/031—Component parts; Auxiliary operations
    • B03C1/033—Component parts; Auxiliary operations characterised by the magnetic circuit
    • B03C1/034—Component parts; Auxiliary operations characterised by the magnetic circuit characterised by the matrix elements
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2400/00—Assays, e.g. immunoassays or enzyme assays, involving carbohydrates
    • G01N2400/10—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
    • G01N2400/12—Homoglycans, i.e. polysaccharides having a main chain consisting of one single sugar
    • G01N2400/14—Homoglycans, i.e. polysaccharides having a main chain consisting of one single sugar alpha-D-Glucans, i.e. having alpha 1,n (n=3,4,6) linkages between saccharide units, e.g. pullulan
    • G01N2400/22—Dextran
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2446/00—Magnetic particle immunoreagent carriers
    • G01N2446/20—Magnetic particle immunoreagent carriers the magnetic material being present in the particle core
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2446/00—Magnetic particle immunoreagent carriers
    • G01N2446/30—Magnetic particle immunoreagent carriers the magnetic material being dispersed in the polymer composition before their conversion into particulate form
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2446/00—Magnetic particle immunoreagent carriers
    • G01N2446/80—Magnetic particle immunoreagent carriers characterised by the agent used to coat the magnetic particles, e.g. lipids
    • G01N2446/90—Magnetic particle immunoreagent carriers characterised by the agent used to coat the magnetic particles, e.g. lipids characterised by small molecule linker used to couple immunoreagents to magnetic particles
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S435/00—Chemistry: molecular biology and microbiology
    • Y10S435/803—Physical recovery methods, e.g. chromatography, grinding

Abstract

Superparamagnetic particles, optionally coated with a polysaccharide or other, usually organic, materials can be prepared in uniform compositions with homogeneous magnetizations using HGMS technique. As a coating they can conveniently be conjugated to a specific binding moiety complementary to a biological material whose purification or separation is desired.
PCT/EP1989/001602 1988-12-28 1989-12-22 Methods and materials for high gradient magnetic separation of biological materials WO1990007380A2 (en)

Priority Applications (2)

Application Number Priority Date Filing Date Title
DE68919715T DE68919715T2 (en) 1988-12-28 1989-12-22 METHOD AND MATERIALS FOR HIGHLY GRADUATED MAGNETIC SPLITTING OF BIOLOGICAL MATERIALS.
EP90900152A EP0452342B1 (en) 1988-12-28 1989-12-22 Methods and materials for high gradient magnetic separation of biological materials

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US29117788A 1988-12-28 1988-12-28
US291,177 1988-12-28

Publications (2)

Publication Number Publication Date
WO1990007380A2 WO1990007380A2 (en) 1990-07-12
WO1990007380A3 true WO1990007380A3 (en) 1990-09-07

Family

ID=23119207

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP1989/001602 WO1990007380A2 (en) 1988-12-28 1989-12-22 Methods and materials for high gradient magnetic separation of biological materials

Country Status (7)

Country Link
US (2) US5411863A (en)
EP (1) EP0452342B1 (en)
AT (1) ATE114507T1 (en)
AU (1) AU4746590A (en)
DE (1) DE68919715T2 (en)
ES (1) ES2067018T3 (en)
WO (1) WO1990007380A2 (en)

Families Citing this family (249)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5385707A (en) * 1988-12-28 1995-01-31 Stefan Miltenyi Metal matrices for use in high gradient magnetic separation of biological materials and method for coating the same
DE68919715T2 (en) * 1988-12-28 1995-04-06 Stefan Miltenyi METHOD AND MATERIALS FOR HIGHLY GRADUATED MAGNETIC SPLITTING OF BIOLOGICAL MATERIALS.
US6020210A (en) * 1988-12-28 2000-02-01 Miltenvi Biotech Gmbh Methods and materials for high gradient magnetic separation of biological materials
US5622831A (en) * 1990-09-26 1997-04-22 Immunivest Corporation Methods and devices for manipulation of magnetically collected material
US5541072A (en) * 1994-04-18 1996-07-30 Immunivest Corporation Method for magnetic separation featuring magnetic particles in a multi-phase system
US5665582A (en) * 1990-10-29 1997-09-09 Dekalb Genetics Corp. Isolation of biological materials
AU8951191A (en) * 1990-10-29 1992-05-26 Dekalb Plant Genetics Isolation of biological materials using magnetic particles
US5370901A (en) * 1991-02-15 1994-12-06 Bracco International B.V. Compositions for increasing the image contrast in diagnostic investigations of the digestive tract of patients
US5795470A (en) * 1991-03-25 1998-08-18 Immunivest Corporation Magnetic separation apparatus
US5186827A (en) * 1991-03-25 1993-02-16 Immunicon Corporation Apparatus for magnetic separation featuring external magnetic means
US6664114B1 (en) 1992-08-03 2003-12-16 Sapidyne Instruments, Inc. Solid phase assay for detection of ligands
AU2593192A (en) 1992-09-14 1994-04-12 Oystein Fodstad Detection of specific target cells in specialized or mixed cell population and solutions containing mixed cell populations
WO1994020855A1 (en) * 1993-03-04 1994-09-15 Sapidyne, Inc. Assay flow apparatus and method
US5868257A (en) * 1993-05-07 1999-02-09 Carpco, Inc. Magnetic separation systems
GB9309446D0 (en) * 1993-05-07 1993-06-23 Carpco Sms Ltd Improvements in and relating to super-conducting magnets
US5514340A (en) * 1994-01-24 1996-05-07 Magnetix Biotechnology, Inc. Device for separating magnetically labelled cells
NO180658C (en) 1994-03-10 1997-05-21 Oeystein Fodstad Method and Device for Detecting Specific Target Cells in Specialized or Mixed Cell Populations and Solutions Containing Mixed Cell Populations
DE4416784A1 (en) * 1994-05-09 1995-11-30 Soft Gene Gmbh Method of enriching cells modified by ballistic transfer
US5705059A (en) * 1995-02-27 1998-01-06 Miltenyi; Stefan Magnetic separation apparatus
DE19516323C2 (en) * 1995-04-27 1997-02-27 Dirk Dipl Chem Guenther Process for the preparation of magnetizable dispersions and their use
DE19520298A1 (en) * 1995-06-02 1996-12-05 Bayer Ag Sorting device for biological cells or viruses
US5639669A (en) * 1995-06-07 1997-06-17 Ledley; Robert Separation of fetal cells from maternal blood
US5741714A (en) * 1995-07-18 1998-04-21 Immunivest Corporation Detection of bound analyte by magnetic partitioning and masking
DE19528029B4 (en) 1995-07-31 2008-01-10 Chemagen Biopolymer-Technologie Aktiengesellschaft Magnetic polymer particles based on polyvinyl alcohol, process for their preparation and use
US6190870B1 (en) 1995-08-28 2001-02-20 Amcell Corporation Efficient enrichment and detection of disseminated tumor cells
US6140040A (en) * 1995-10-06 2000-10-31 Advanced Minerals Corporation Method of mechanically separating microparticles suspended in fluids using particulate media
NO961031D0 (en) 1996-03-13 1996-03-13 Det Norske Radiumshospital Tum Procedure for killing unwanted target cells
DE19612001A1 (en) * 1996-03-18 1997-09-25 Silica Gel Gmbh Adsorptions Te Superparamagnetic particles with increased R¶1¶ relaxivity, process for their production and their use
US6455678B1 (en) 1996-04-26 2002-09-24 Amcell Corporation Human hematopoietic stem and progenitor cell antigen
US5843633A (en) * 1996-04-26 1998-12-01 Amcell Corporation Characterization of a human hematopoietic progenitor cell antigen
US7666308B2 (en) * 1996-06-07 2010-02-23 Veridex, Llc. Magnetic separation apparatus and methods
US6890426B2 (en) * 1996-06-07 2005-05-10 Immunivest Corporation Magnetic separation apparatus and methods
US6790366B2 (en) * 1996-06-07 2004-09-14 Immunivest Corporation Magnetic separation apparatus and methods
US6660159B1 (en) 1996-06-07 2003-12-09 Immunivest Corporation Magnetic separation apparatus and methods
US5993665A (en) * 1996-06-07 1999-11-30 Immunivest Corporation Quantitative cell analysis methods employing magnetic separation
US6136182A (en) * 1996-06-07 2000-10-24 Immunivest Corporation Magnetic devices and sample chambers for examination and manipulation of cells
IL128057A (en) * 1996-08-05 2001-08-26 Schering Ag Process for the production of contrast media
US5817458A (en) * 1996-10-15 1998-10-06 The Avriel Group, Amcas Division Inc. Reagent system for detecting HIV-infected peripheral blood lymphocytes in whole blood
EP0933989A1 (en) * 1996-10-15 1999-08-11 Bio-Tech Imaging, Inc. Reagent system and kit for detecting hiv infected cells
US5779892A (en) * 1996-11-15 1998-07-14 Miltenyi Biotec Gmbh Magnetic separator with magnetic compensated release mechanism for separating biological material
US5798206A (en) * 1997-01-10 1998-08-25 New York Blood Center Methods for screening of test compounds for inhibiting binding of a CD4-HIV 1 complex to a chemokine receptor
FR2758884B1 (en) 1997-01-30 1999-04-02 Bio Merieux METHOD FOR ISOLATING, IN PARTICULAR DETECTING OR QUANTIFYING AN ANALYTE IN A MEDIUM
US6241894B1 (en) 1997-10-10 2001-06-05 Systemix High gradient magnetic device and method for cell separation or purification
CA2260991C (en) 1997-11-18 2009-03-24 Bio-Rad Laboratories, Inc. Multiplex flow immunoassays with magnetic particles as solid phase
US6337215B1 (en) * 1997-12-01 2002-01-08 International Business Machines Corporation Magnetic particles having two antiparallel ferromagnetic layers and attached affinity recognition molecules
EP0941766B1 (en) 1998-03-12 2006-12-20 Miltenyi Biotec GmbH Micro column system for magnetic separation
US7220596B2 (en) 1998-04-15 2007-05-22 Utah State University Real time detection of antigens
JP4601166B2 (en) 1998-05-11 2010-12-22 ミルテニィ バイオテック ゲーエムベーハー Method for directly selecting antigen-specific T cells
ES2313800T3 (en) * 1998-11-30 2009-03-01 Veridex, Llc APPARATUS AND MAGNETIC SEPARATION PROCEDURE.
US7364921B1 (en) 1999-01-06 2008-04-29 University Of Medicine And Dentistry Of New Jersey Method and apparatus for separating biological materials and other substances
US6159378A (en) * 1999-02-23 2000-12-12 Battelle Memorial Institute Apparatus and method for handling magnetic particles in a fluid
US6193892B1 (en) 1999-03-03 2001-02-27 Promega Corporation Magnetic separation assembly and method
EP1177424A4 (en) 1999-04-09 2005-04-06 Shot Inc Multistage electromagnetic separator for purifying cells, chemicals and protein structures
DE19938372A1 (en) * 1999-08-09 2001-03-08 Diagnostikforschung Inst Method and device for separating magnetic particles
JP4612982B2 (en) 1999-09-03 2011-01-12 ミルテニィ バイオテック ゲーエムベーハー Method for modifying selected cells in a magnetic cell separation column
US7169618B2 (en) 2000-06-28 2007-01-30 Skold Technology Magnetic particles and methods of producing coated magnetic particles
US6984522B2 (en) 2000-08-03 2006-01-10 Regents Of The University Of Michigan Isolation and use of solid tumor stem cells
ATE349011T1 (en) * 2000-10-03 2007-01-15 Minerva Biotechnologies Corp MAGNETIC IN SITU DILUTION PROCESS
US6649419B1 (en) * 2000-11-28 2003-11-18 Large Scale Proteomics Corp. Method and apparatus for protein manipulation
FR2817967B1 (en) * 2000-12-08 2003-02-28 Diagast PROCESS FOR MAGNETIZING CHEMICAL OR BIOLOGICAL MARKERS
US20030095897A1 (en) * 2001-08-31 2003-05-22 Grate Jay W. Flow-controlled magnetic particle manipulation
DE60233248D1 (en) 2001-11-15 2009-09-17 Childrens Medical Center PROCESS FOR THE ISOLATION, EXPANSION AND DIFFERENTIATION OF FEDERAL STRAIN CELLS FROM CHORION ZOTTE, FRUIT WATER AND PLAZENTA AND THERAPEUTIC USES THEREOF
US20030099954A1 (en) * 2001-11-26 2003-05-29 Stefan Miltenyi Apparatus and method for modification of magnetically immobilized biomolecules
US7232691B2 (en) * 2001-11-27 2007-06-19 Los Alamos National Security, Llc Bioassay and biomolecular identification, sorting, and collection methods using magnetic microspheres
AU2002359648A1 (en) * 2001-12-07 2003-06-23 Dyax Corporation Method and apparatus for washing magnetically responsive particles
US7514270B2 (en) * 2002-04-12 2009-04-07 Instrumentation Laboratory Company Immunoassay probe
US9435799B2 (en) * 2002-07-31 2016-09-06 Janssen Diagnostics, Inc. Methods and reagents for improved selection of biological materials
US20040067532A1 (en) 2002-08-12 2004-04-08 Genetastix Corporation High throughput generation and affinity maturation of humanized antibody
EP1540348A4 (en) 2002-08-27 2006-10-11 Stemcells California Inc Enriched central nervous system stem cell and progenitor cell populations, and methods for identifying, isolating and enriching for such populations
DE10331439B3 (en) 2003-07-10 2005-02-03 Micromod Partikeltechnologie Gmbh Magnetic nanoparticles with improved magnetic properties
US7601491B2 (en) * 2003-02-06 2009-10-13 Becton, Dickinson And Company Pretreatment method for extraction of nucleic acid from biological samples and kits therefor
DE112004002408B4 (en) * 2003-12-10 2008-04-30 University Of Utah Research Foundation, Salt Lake City A method for obtaining an enriched population of siRNA-expressing cells
WO2005065267A2 (en) * 2003-12-24 2005-07-21 Massachusetts Institute Of Technology Magnetophoretic cell clarification
US8211386B2 (en) * 2004-06-08 2012-07-03 Biokit, S.A. Tapered cuvette and method of collecting magnetic particles
US9790539B2 (en) * 2004-06-30 2017-10-17 Russell Biotech, Inc. Methods and reagents for improved selection of biological molecules
US20060024776A1 (en) * 2004-08-02 2006-02-02 Mcmillian Ray Magnetic particle capture of whole intact organisms from clinical samples
WO2006017427A1 (en) * 2004-08-03 2006-02-16 Becton, Dickinson And Company Use of magnetic material to fractionate samples
WO2006112771A1 (en) * 2005-04-18 2006-10-26 Ge Healthcare Bio-Sciences Ab Magnetic beads
WO2007079149A2 (en) * 2005-12-28 2007-07-12 The General Hospital Corporation Blood cell sorting methods and systems
US7862813B2 (en) 2006-07-29 2011-01-04 Bjork Jr Robert Lamar Bi-specific monoclonal antibody (specific for both CD3 and CD11b) therapeutic drug
US8168393B2 (en) 2007-02-16 2012-05-01 The Brigham And Women's Hospital, Inc. Compositions and methods for diagnosing tumors using LEDGF/p75
DE102007043281A1 (en) 2007-09-11 2009-05-28 Sebastian Dr. med. Chakrit Bhakdi Apparatus, materials and methods for high gradient magnetic separation of biological material
EP2193146B1 (en) 2007-09-14 2016-05-25 Adimab, LLC Rationally designed, synthetic antibody libraries and uses therefor
US8877688B2 (en) 2007-09-14 2014-11-04 Adimab, Llc Rationally designed, synthetic antibody libraries and uses therefor
ES2640216T3 (en) 2007-12-07 2017-11-02 Miltenyi Biotec Gmbh Systems and methods for cell processing
US8338170B2 (en) 2008-04-21 2012-12-25 Viacyte, Inc. Methods for purifying endoderm and pancreatic endoderm cells derived from human embryonic stem cells
DK2727998T3 (en) 2008-04-21 2019-08-26 Viacyte Inc Methods for purifying pancreatic endoderm cells derived from human embryonic stem cells
US20110177592A1 (en) * 2008-07-11 2011-07-21 Faustman Denise L Magnetic apparatus for blood separation
EP2356227B1 (en) 2008-11-14 2018-03-28 Viacyte, Inc. Encapsulation of pancreatic cells derived from human pluripotent stem cells
US20100158878A1 (en) 2008-12-23 2010-06-24 Alexandra Capela Target populations of oligodendrocyte precursor cells and methods of making and using same
GB0823553D0 (en) 2008-12-24 2009-01-28 Immunosolv Ltd Cell separation technique
US8790916B2 (en) * 2009-05-14 2014-07-29 Genestream, Inc. Microfluidic method and system for isolating particles from biological fluid
WO2011007310A1 (en) 2009-07-17 2011-01-20 Koninklijke Philips Electronics N.V. Apparatus for the enrichment of magnetic particles
US8083069B2 (en) * 2009-07-31 2011-12-27 General Electric Company High throughput magnetic isolation technique and device for biological materials
TWI362964B (en) * 2009-12-23 2012-05-01 Ind Tech Res Inst Magnetic separation device and method for separating magnetic substances in bio-samples
EP2390661B1 (en) 2010-05-02 2015-06-24 Miltenyi Biotec GmbH An anchoring/capturing means for selecting or analyzing a CHO cell according to a product secreted by the CHO cell
DE102011015321A1 (en) 2011-03-28 2012-10-04 Ralph Heindrichs Method for separating leucocyte from blood, involves forming openings through which to-be-separated particles are deflected in separation channel
US9494557B2 (en) 2011-04-05 2016-11-15 Purdue Research Foundation Micro-fluidic system using micro-apertures for high throughput detection of cells
TWI407101B (en) 2011-04-11 2013-09-01 Ind Tech Res Inst Magnetic separation unit, magnetic separation device and method for separating magnetic substances in bio-samples
US9885642B2 (en) 2011-04-27 2018-02-06 Becton, Dickinson And Company Devices and methods for separating magnetically labeled moieties in a sample
ES2602500T3 (en) 2011-11-25 2017-02-21 Miltenyi Biotec Gmbh Cell separation method
ES2616289T3 (en) 2012-03-01 2017-06-12 Miltenyi Biotec Gmbh Separation of intact living neurons
DE102012213032A1 (en) * 2012-07-25 2014-01-30 Siemens Aktiengesellschaft Method for dewaterning water-containing cell culture, involves providing water-containing cell culture with magnetic particles, where water-containing cell culture is applied with magnetic field for producing forces
DK2890498T3 (en) 2012-08-29 2018-05-22 Inguran Llc MAGNETIC REMOVAL OR IDENTIFICATION OF DAMAGED OR COMPRIMATED CELLS OR CELL STRUCTURES
US10379026B2 (en) 2012-08-29 2019-08-13 Inguran, Llc Cell processing using magnetic particles
CN110595987A (en) 2012-10-26 2019-12-20 贝克顿·迪金森公司 Apparatus and method for manipulating components in a fluid sample
EP2787006B1 (en) 2013-04-02 2018-02-28 Miltenyi Biotec GmbH Anti-CD8 antibody which binding is Ca2+ dependent
US9884326B2 (en) * 2013-06-28 2018-02-06 National Institute Of Advanced Industrial Science And Technology Matrix for magnetic separator and magnetic separator
CN113046312A (en) 2014-04-23 2021-06-29 朱诺治疗学股份有限公司 Methods of isolating, culturing and genetically engineering immune cell populations for adoptive therapy
JP2017521091A (en) 2014-05-15 2017-08-03 ケルベンクス インコーポレイテッド Preparation of fetal nucleated red blood cells (NRBC) for diagnostic tests
EP2955521A1 (en) 2014-06-11 2015-12-16 Centre Hospitalier Universitaire Vaudois (CHUV) Methods for separating cells
MA40253A (en) 2014-07-15 2017-05-24 Juno Therapeutics Inc Engineered cells for adoptive cell therapy
TWI751102B (en) 2014-08-28 2022-01-01 美商奇諾治療有限公司 Antibodies and chimeric antigen receptors specific for cd19
ES2879612T3 (en) 2014-10-20 2021-11-22 Juno Therapeutics Inc Methods and compositions for dosage in adoptive cell therapy
MA40318A (en) 2014-11-05 2017-09-13 Juno Therapeutics Inc CELL TRANSDUCTION AND TREATMENT PROCESSES
MX2017007138A (en) 2014-12-03 2017-08-28 Juno Therapeutics Inc Methods and compositions for adoptive cell therapy.
MA41346A (en) 2015-01-12 2017-11-21 Juno Therapeutics Inc POST-TRANSCRIPTIONAL REGULATORY ELEMENTS OF MODIFIED HEPATITIS
US20160208018A1 (en) 2015-01-16 2016-07-21 Juno Therapeutics, Inc. Antibodies and chimeric antigen receptors specific for ror1
WO2016166568A1 (en) 2015-04-16 2016-10-20 Juno Therapeutics Gmbh Methods, kits and apparatus for expanding a population of cells
CA2986060A1 (en) 2015-05-29 2016-12-08 Valerie Odegard Composition and methods for regulating inhibitory interactions in genetically engineered cells
MA42895A (en) 2015-07-15 2018-05-23 Juno Therapeutics Inc MODIFIED CELLS FOR ADOPTIVE CELL THERAPY
MA45488A (en) 2015-10-22 2018-08-29 Juno Therapeutics Gmbh CELL CULTURE PROCESSES, KITS AND APPARATUS
CN116875635A (en) 2015-10-22 2023-10-13 朱诺治疗学有限公司 Method, reagent cartridge, reagent and device for transduction
MA45489A (en) 2015-10-22 2018-08-29 Juno Therapeutics Gmbh CELL CULTURE PROCESSES, ASSOCIATED KITS AND APPARATUS
US11020429B2 (en) 2015-11-05 2021-06-01 Juno Therapeutics, Inc. Vectors and genetically engineered immune cells expressing metabolic pathway modulators and uses in adoptive cell therapy
MA44314A (en) 2015-11-05 2018-09-12 Juno Therapeutics Inc CHEMERICAL RECEPTORS CONTAINING TRAF-INDUCING DOMAINS, AND ASSOCIATED COMPOSITIONS AND METHODS
US10625272B2 (en) 2015-11-18 2020-04-21 Industrial Technology Research Institute Magnetic separator
AU2016363025B2 (en) 2015-12-03 2021-04-08 Juno Therapeutics, Inc. Modified chimeric receptors and related compositions and methods
MA43378A (en) 2015-12-03 2018-10-10 Juno Therapeutics Inc COMPOSITIONS AND METHODS FOR REDUCTION OF IMMUNE RESPONSE AGAINST CHEMERIC ANTIGEN RECEPTORS
MA43377A (en) 2015-12-04 2021-05-19 Hutchinson Fred Cancer Res METHODS AND COMPOSITIONS RELATED TO TOXICITY ASSOCIATED WITH CELL THERAPY
CN108601731A (en) 2015-12-16 2018-09-28 磨石肿瘤生物技术公司 Discriminating, manufacture and the use of neoantigen
EP3430548A1 (en) 2016-03-16 2019-01-23 Juno Therapeutics, Inc. Methods for determining dosing of a therapeutic agent and related treatments
EP3430549A1 (en) 2016-03-16 2019-01-23 Juno Therapeutics, Inc. Methods for adaptive design of a treatment regimen and related treatments
EP4015536A1 (en) 2016-03-22 2022-06-22 Seattle Children's Hospital (DBA Seattle Children's Research Institute) Early intervention methods to prevent or ameliorate toxicity
CA3026453A1 (en) 2016-06-03 2017-12-07 Memorial Sloan-Kettering Cancer Center Adoptive cell therapies as early treatment options
MA45341A (en) 2016-06-06 2019-04-10 Hutchinson Fred Cancer Res METHODS FOR TREATING B-LYMPHOCYTE MALIGNITIES USING ADOPTIVE CELL THERAPY
CA3028002A1 (en) 2016-06-27 2018-01-04 Juno Therapeutics, Inc. Method of identifying peptide epitopes, molecules that bind such epitopes and related uses
MA45491A (en) 2016-06-27 2019-05-01 Juno Therapeutics Inc CMH-E RESTRICTED EPITOPES, BINDING MOLECULES AND RELATED METHODS AND USES
ES2926513T3 (en) 2016-07-29 2022-10-26 Juno Therapeutics Inc Methods for Assessing the Presence or Absence of Replication-Competent Virus
MX2019001185A (en) 2016-07-29 2019-10-21 Juno Therapeutics Inc Immunomodulatory polypeptides and related compositions and methods.
CN110088133B (en) 2016-07-29 2023-12-08 朱诺治疗学股份有限公司 Anti-idiotype antibodies and related methods
EP3957997A1 (en) 2016-08-26 2022-02-23 Juno Therapeutics, Inc. Methods of enumerating particles present in a cell composition
CA3035829A1 (en) 2016-09-12 2018-03-15 Juno Therapeutics, Inc. Perfusion bioreactor bag assemblies
CN110139873A (en) 2016-10-03 2019-08-16 朱诺治疗学股份有限公司 HPV specific binding molecules
US11896615B2 (en) 2016-10-13 2024-02-13 Juno Therapeutics, Inc. Immunotherapy methods and compositions involving tryptophan metabolic pathway modulators
US20190292246A1 (en) 2016-11-03 2019-09-26 Juno Therapeutics, Inc. Combination therapy of a cell based therapy and a microglia imhibitor
WO2018085731A2 (en) 2016-11-03 2018-05-11 Juno Therapeutics, Inc. Combination therapy of a t cell therapy and a btk inhibitor
CN110494565A (en) 2016-12-02 2019-11-22 朱诺治疗学股份有限公司 It is engineered B cell and compositions related and method
MA46995A (en) 2016-12-03 2019-10-09 Acerta Pharma Bv METHODS AND COMPOSITIONS FOR THE USE OF THERAPEUTIC T-LYMPHOCYTES IN COMBINATION WITH KINASE INHIBITORS
US20200078400A1 (en) 2016-12-03 2020-03-12 Juno Therapeutics, Inc. Methods for determining car-t cells dosing
CA3045508A1 (en) 2016-12-03 2018-06-07 Juno Therapeutics, Inc. Methods for modulation of car-t cells
JP2019536461A (en) 2016-12-05 2019-12-19 ジュノー セラピューティクス インコーポレイテッド Production of engineered cells for adoptive cell therapy
AU2018207305A1 (en) 2017-01-10 2019-07-25 Juno Therapeutics, Inc. Epigenetic analysis of cell therapy and related methods
CN110418802A (en) 2017-01-20 2019-11-05 朱诺治疗学有限公司 Cell surface conjugate and relevant cell composition and method
CA3052779A1 (en) 2017-02-17 2018-08-23 Fred Hutchinson Cancer Research Center Combination therapies for treatment of bcma-related cancers and autoimmune disorders
BR112019017767A2 (en) 2017-02-27 2020-04-07 Juno Therapeutics Inc compositions, articles of manufacture and methods related to dosing in cell therapy
AU2018234640B2 (en) 2017-03-14 2024-03-14 Juno Therapeutics, Inc. Methods for cryogenic storage
WO2018187791A1 (en) 2017-04-07 2018-10-11 Juno Therapeutics, Inc Engineered cells expressing prostate-specific membrane antigen (psma) or a modified form thereof and related methods
AU2018251188A1 (en) 2017-04-14 2019-10-31 Juno Therapeutics, Inc. Methods for assessing cell surface glycosylation
BR112019022356A2 (en) 2017-04-27 2020-05-26 Juno Therapeutics Gmbh OLIGOMERIC PARTICLE REAGENTS AND METHODS OF USE THEREOF
CA3061945A1 (en) 2017-05-01 2018-11-08 Juno Therapeutics, Inc. Combination of a cell therapy and an immunomodulatory compound
MA48781A (en) 2017-06-02 2020-04-08 Juno Therapeutics Inc ARTICLES OF MANUFACTURING AND PROCESSES RELATED TO TOXICITY ASSOCIATED WITH CELL THERAPY
WO2018223101A1 (en) 2017-06-02 2018-12-06 Juno Therapeutics, Inc. Articles of manufacture and methods for treatment using adoptive cell therapy
EP3638774A1 (en) 2017-06-14 2020-04-22 Helmholtz Zentrum München - Deutsches Forschungszentrum für Gesundheit und Umwelt (GmbH) Methods for purifying endoderm and pancreatic endoderm cells derived from human embryonic stem cells
WO2018231373A1 (en) * 2017-06-14 2018-12-20 Russell Biotech, Inc. Preparation of platelet free mononuclear cells
JP2020526194A (en) 2017-06-29 2020-08-31 ジュノー セラピューティクス インコーポレイテッド Mouse model for assessing toxicity associated with immunotherapeutic agents
BR112020001719A2 (en) 2017-07-29 2020-07-21 Juno Therapeutics Inc reagents for cell expansion that express recombinant receptors
ES2959953T3 (en) 2017-08-09 2024-02-29 Juno Therapeutics Inc Methods for producing genetically modified cellular compositions and related compositions
BR112020001601A2 (en) 2017-08-09 2020-08-11 Juno Therapeutics Inc methods and compositions for preparing genetically engineered cells
MA50057A (en) 2017-09-01 2020-07-08 Juno Therapeutics Inc GENE EXPRESSION AND ASSESSMENT OF A RISK OF DEVELOPING TOXICITY FOLLOWING CELL THERAPY
WO2019051335A1 (en) 2017-09-07 2019-03-14 Juno Therapeutics, Inc. Methods of identifying cellular attributes related to outcomes associated with cell therapy
CA3080546A1 (en) 2017-10-03 2019-04-11 Juno Therapeutics, Inc. Hpv-specific binding molecules
KR20200087143A (en) 2017-10-10 2020-07-20 그릿스톤 온콜로지, 인코포레이티드 Identification of new antigens using hot spots
WO2019089848A1 (en) 2017-11-01 2019-05-09 Juno Therapeutics, Inc. Methods associated with tumor burden for assessing response to a cell therapy
MA50855A (en) 2017-11-01 2020-09-09 Juno Therapeutics Inc PROCESS FOR GENERATING THERAPEUTIC COMPOSITIONS OF MODIFIED CELLS
SG11202003657VA (en) 2017-11-01 2020-05-28 Juno Therapeutics Inc Process for producing a t cell composition
WO2019089858A2 (en) 2017-11-01 2019-05-09 Juno Therapeutics, Inc. Methods of assessing or monitoring a response to a cell therapy
KR20200116077A (en) 2017-11-01 2020-10-08 주노 쎄러퓨티크스 인코퍼레이티드 Chimeric antigen receptor and coding polynucleotide specific for B cell maturation antigen
CA3080904A1 (en) 2017-11-01 2019-05-09 Juno Therapeutics, Inc. Antibodies and chimeric antigen receptors specific for b-cell maturation antigen
WO2019090364A1 (en) 2017-11-06 2019-05-09 Juno Therapeutics, Inc. Combination of a cell therapy and a gamma secretase inhibitor
WO2019094835A1 (en) 2017-11-10 2019-05-16 Juno Therapeutics, Inc. Closed-system cryogenic vessels
CA3083097A1 (en) 2017-11-22 2019-05-31 Gritstone Oncology, Inc. Reducing junction epitope presentation for neoantigens
CN111989106A (en) 2017-12-01 2020-11-24 朱诺治疗学股份有限公司 Methods of administering and regulating genetically engineered cells
KR20200109308A (en) 2017-12-08 2020-09-22 주노 쎄러퓨티크스 인코퍼레이티드 Phenotypic markers and related methods for cell therapy
MX2020005908A (en) 2017-12-08 2020-10-07 Juno Therapeutics Inc Process for producing a composition of engineered t cells.
BR112020011144A2 (en) 2017-12-08 2020-11-17 Juno Therapeutics Inc formulation of serum-free medium for cell culture and methods of using it
EP3724225A1 (en) 2017-12-15 2020-10-21 Juno Therapeutics, Inc. Anti-cct5 binding molecules and methods of use thereof
JP2021511802A (en) 2018-01-31 2021-05-13 ジュノー セラピューティクス インコーポレイテッド Methods and Reagents for Assessing the Presence or Absence of Replicate Virus
JP7383620B2 (en) 2018-01-31 2023-11-20 セルジーン コーポレイション Combination therapy using adoptive cell therapy and checkpoint inhibitors
WO2019169194A1 (en) 2018-02-28 2019-09-06 Juno Therapeutics, Inc. Methods for detecting particles present in a cell composition
WO2019170845A1 (en) 2018-03-09 2019-09-12 Ospedale San Raffaele S.R.L. Il-1 antagonist and toxicity induced by cell therapy
MX2020010461A (en) 2018-04-05 2021-01-15 Juno Therapeutics Inc T cells expressing a recombinant receptor, related polynucleotides and methods.
CN112566698A (en) 2018-04-05 2021-03-26 朱诺治疗学股份有限公司 T cell receptor and engineered cells expressing the same
EP3775238A1 (en) 2018-04-05 2021-02-17 Juno Therapeutics, Inc. Methods of producing cells expressing a recombinant receptor and related compositions
CA3098497A1 (en) 2018-05-03 2019-11-07 Juno Therapeutics, Inc. Combination therapy of a chimeric antigen receptor (car) t cell therapy and a kinase inhibitor
EP3807305A4 (en) 2018-06-13 2022-04-20 Akron Biotechnology, LLC Method to prepare therapeutically active aldesleukin highly stable in liquid pharmaceutical compositions
US20210230671A1 (en) 2018-08-09 2021-07-29 Juno Therapeutics, Inc. Methods for assessing integrated nucleic acids
US20210163893A1 (en) 2018-08-09 2021-06-03 Juno Therapeutics, Inc. Processes for generating engineered cells and compositions thereof
CA3110905A1 (en) 2018-08-31 2020-03-05 Invectys SA Chimeric antigen receptors against multiple hla-g isoforms
CN113167796A (en) 2018-09-11 2021-07-23 朱诺治疗学股份有限公司 Methods for performing mass spectrometry on engineered cell compositions
WO2020092848A2 (en) 2018-11-01 2020-05-07 Juno Therapeutics, Inc. Methods for treatment using chimeric antigen receptors specific for b-cell maturation antigen
WO2020092854A2 (en) 2018-11-01 2020-05-07 Juno Therapeutics, Inc. Chimeric antigen receptors specific for g protein-coupled receptor class c group 5 member d (gprc5d)
EP3877054B1 (en) 2018-11-06 2023-11-01 Juno Therapeutics, Inc. Process for producing genetically engineered t cells
AU2019377854A1 (en) 2018-11-08 2021-05-27 Juno Therapeutics, Inc. Methods and combinations for treatment and T cell modulation
JP2022513062A (en) 2018-11-16 2022-02-07 ジュノー セラピューティクス インコーポレイテッド Methods of Dosing Manipulated T Cells to Treat B-Cell Malignancies
JP2022513685A (en) 2018-11-30 2022-02-09 ジュノー セラピューティクス インコーポレイテッド Methods for Treatment with Adoptive Cell Therapy
MX2021006244A (en) 2018-11-30 2021-09-10 Juno Therapeutics Inc Methods for dosing and treatment of b cell malignancies in adoptive cell therapy.
PE20212198A1 (en) 2019-01-29 2021-11-16 Juno Therapeutics Inc ANTIBODIES AND CHIMERIC RECEPTORS OF SPECIFIC ANTIGENS TO ORPHAN RECEPTOR 1, RECEPTOR TYROSINE KINASE TYPE (ROR1)
EP3693739A1 (en) 2019-02-06 2020-08-12 Stefan Schreier Method and device for isolating desired cells from a sample of nonmagnetic biological material
AU2020265741A1 (en) 2019-05-01 2021-11-25 Editas Medicine, Inc. Cells expressing a recombinant receptor from a modified TGFBR2 Locus, related polynucleotides and methods
MX2021013223A (en) 2019-05-01 2022-02-17 Juno Therapeutics Inc Cells expressing a chimeric receptor from a modified cd247 locus, related polynucleotides and methods.
US20230258663A9 (en) 2019-05-02 2023-08-17 Kellbenx Incorporated Filtration-based methods for preparing fetal nucleated red blood cells (nrbcs) for diagnostic testing
US20220249637A1 (en) 2019-06-12 2022-08-11 Juno Therapeutics, Inc. Combination therapy of a cell-mediated cytotoxic therapy and an inhibitor of a prosurvival bcl2 family protein
WO2021035194A1 (en) 2019-08-22 2021-02-25 Juno Therapeutics, Inc. Combination therapy of a t cell therapy and an enhancer of zeste homolog 2 (ezh2) inhibitor and related methods
WO2021041994A2 (en) 2019-08-30 2021-03-04 Juno Therapeutics, Inc. Machine learning methods for classifying cells
WO2021092097A1 (en) 2019-11-05 2021-05-14 Juno Therapeutics, Inc. Methods of determining attributes of therapeutic t cell compositions
US20220401483A1 (en) 2019-11-07 2022-12-22 Juno Therapeutics, Inc. Combination of a t cell therapy and (s)-3-[4-(4-morpholin-4-ylmethyl-benzyloxy)-l-oxo-l,3-dihydro-isoindol-2-yl]-piperidine-2,6-dione
WO2021113780A1 (en) 2019-12-06 2021-06-10 Juno Therapeutics, Inc. Anti-idiotypic antibodies to gprc5d-targeted binding domains and related compositions and methods
JP2023504737A (en) 2019-12-06 2023-02-06 ジュノー セラピューティクス インコーポレイテッド Methods relating to toxicity and efficacy associated with cell therapy for treating B-cell malignancies
JP2023504740A (en) 2019-12-06 2023-02-06 ジュノー セラピューティクス インコーポレイテッド Anti-idiotypic antibodies against BCMA target binding domains and related compositions and methods
AU2021209940A1 (en) 2020-01-24 2022-08-04 Juno Therapeutics, Inc. Methods for dosing and treatment of follicular lymphoma and marginal zone lymphoma in adoptive cell therapy
WO2021154887A1 (en) 2020-01-28 2021-08-05 Juno Therapeutics, Inc. Methods for t cell transduction
EP4103204A1 (en) 2020-02-12 2022-12-21 Juno Therapeutics, Inc. Cd19-directed chimeric antigen receptor t cell compositions and methods and uses thereof
JP2023519099A (en) 2020-02-12 2023-05-10 ジュノー セラピューティクス インコーポレイテッド BCMA-directed chimeric antigen receptor T-cell compositions and methods and uses thereof
KR20230009386A (en) 2020-04-10 2023-01-17 주노 쎄러퓨티크스 인코퍼레이티드 Methods and uses for cell therapy engineered with chimeric antigen receptors targeting B-cell maturation antigens
EP4142723A2 (en) 2020-04-28 2023-03-08 Juno Therapeutics, Inc. Combination of bcma-directed t cell therapy and an immunomodulatory compound
JP2023528215A (en) 2020-05-13 2023-07-04 ジュノー セラピューティクス インコーポレイテッド Methods of identifying features associated with clinical response and uses thereof
KR20230022868A (en) 2020-05-13 2023-02-16 주노 쎄러퓨티크스 인코퍼레이티드 Method for producing donor-batch cells expressing a recombinant acceptor
WO2021260186A1 (en) 2020-06-26 2021-12-30 Juno Therapeutics Gmbh Engineered t cells conditionally expressing a recombinant receptor, related polynucleotides and methods
EP4192868A1 (en) 2020-08-05 2023-06-14 Juno Therapeutics, Inc. Anti-idiotypic antibodies to ror1-targeted binding domains and related compositions and methods
WO2022098787A1 (en) 2020-11-04 2022-05-12 Juno Therapeutics, Inc. Cells expressing a chimeric receptor from a modified invariant cd3 immunoglobulin superfamily chain locus and related polynucleotides and methods
WO2022133030A1 (en) 2020-12-16 2022-06-23 Juno Therapeutics, Inc. Combination therapy of a cell therapy and a bcl2 inhibitor
CN117693508A (en) 2021-03-03 2024-03-12 朱诺治疗学股份有限公司 Combination of T cell therapy and DGK inhibitors
KR20230159851A (en) 2021-03-22 2023-11-22 주노 쎄러퓨티크스 인코퍼레이티드 How to Determine the Potency of a Therapeutic Cell Composition
WO2022212400A1 (en) 2021-03-29 2022-10-06 Juno Therapeutics, Inc. Methods for dosing and treatment with a combination of a checkpoint inhibitor therapy and a car t cell therapy
WO2022212384A1 (en) 2021-03-29 2022-10-06 Juno Therapeutics, Inc. Combination of a car t cell therapy and an immunomodulatory compound for treatment of lymphoma
KR20230171468A (en) 2021-04-16 2023-12-20 셀진 코포레이션 Combination therapy with BCMA-directed T cell therapy
WO2023081735A1 (en) 2021-11-03 2023-05-11 Celgene Corporation Chimeric antigen receptors specific for b-cell maturation antigen for use in treating myeloma
WO2023081900A1 (en) 2021-11-08 2023-05-11 Juno Therapeutics, Inc. Engineered t cells expressing a recombinant t cell receptor (tcr) and related systems and methods
WO2023147515A1 (en) 2022-01-28 2023-08-03 Juno Therapeutics, Inc. Methods of manufacturing cellular compositions
WO2023164440A1 (en) 2022-02-22 2023-08-31 Juno Therapeutics, Inc. Proteinase 3 (pr3) chimeric autoantibody receptor t cells and related methods and uses
WO2023220655A1 (en) 2022-05-11 2023-11-16 Celgene Corporation Methods to overcome drug resistance by re-sensitizing cancer cells to treatment with a prior therapy via treatment with a t cell therapy
WO2023230548A1 (en) 2022-05-25 2023-11-30 Celgene Corporation Method for predicting response to a t cell therapy
WO2023230581A1 (en) 2022-05-25 2023-11-30 Celgene Corporation Methods of manufacturing t cell therapies
WO2023250400A1 (en) 2022-06-22 2023-12-28 Juno Therapeutics, Inc. Treatment methods for second line therapy of cd19-targeted car t cells
WO2024006960A1 (en) 2022-06-29 2024-01-04 Juno Therapeutics, Inc. Lipid nanoparticles for delivery of nucleic acids
WO2024031091A2 (en) 2022-08-05 2024-02-08 Juno Therapeutics, Inc. Chimeric antigen receptors specific for gprc5d and bcma
WO2024044779A2 (en) 2022-08-26 2024-02-29 Juno Therapeutics, Inc. Antibodies and chimeric antigen receptors specific for delta-like ligand 3 (dll3)
WO2024054944A1 (en) 2022-09-08 2024-03-14 Juno Therapeutics, Inc. Combination of a t cell therapy and continuous or intermittent dgk inhibitor dosing

Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1983002405A1 (en) * 1982-01-14 1983-07-21 Reed, Thomas, A. Method and apparatus for separating organic substances from a suspension or a solution
US4452773A (en) * 1982-04-05 1984-06-05 Canadian Patents And Development Limited Magnetic iron-dextran microspheres
EP0125995A2 (en) * 1983-05-12 1984-11-21 Advanced Magnetics, Inc. Magnetic particles for use in separations
US4526681A (en) * 1983-10-31 1985-07-02 Purdue Research Foundation Magnetic separation method utilizing a colloid of magnetic particles
US4677067A (en) * 1984-06-22 1987-06-30 Bio-Magnetech Corporation Magnetotactic bacteria in clinical assay, immunoassay, and cell separation procedures and the like
DE3624626A1 (en) * 1986-07-18 1988-01-28 Pilgrimm Herbert Process for separating off substances from a mixture of substances using magnetic liquids

Family Cites Families (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1235686A (en) * 1967-02-16 1971-06-16 Rolf Saxholm Improvements in diffusion testing and apparatus therefor
US4992377B1 (en) * 1967-02-16 1996-10-15 Saxholm As Article for carrying out biological or chemical procedures containing magnetically responsive material
US4371624A (en) * 1976-08-23 1983-02-01 Rolf Saxholm Apparatus and testing reactions
US4213825A (en) * 1976-08-23 1980-07-22 Rolf Saxholm Apparatus for testing reactions
US4021308A (en) * 1967-02-16 1977-05-03 Rolf Saxholm Apparatus associated with magnetically responsive, biologically active substance for testing thereof
US3981776A (en) * 1967-02-16 1976-09-21 Rolf Saxholm Magnetically responsive, biologically active substance and associated methods and apparatus
NO124603B (en) * 1969-05-03 1972-05-08 Rolf Saxholm
US4140582A (en) * 1969-05-03 1979-02-20 Rolf Saxholm Supporting element for use in microbiological, serological, immunological clinical-chemical and similar laboratory work
US3985608A (en) * 1969-05-03 1976-10-12 Rolf Saxholm Supporting element for use in microbiological, serological, immunological, clinical-chemical and similar laboratory work
US4018886A (en) * 1975-07-01 1977-04-19 General Electric Company Diagnostic method and device employing protein-coated magnetic particles
US3970518A (en) * 1975-07-01 1976-07-20 General Electric Company Magnetic separation of biological particles
US4230685A (en) * 1979-02-28 1980-10-28 Northwestern University Method of magnetic separation of cells and the like, and microspheres for use therein
US4657868A (en) * 1980-01-15 1987-04-14 Rolf Saxholm Apparatus for testing reactions
US4375407A (en) * 1981-06-22 1983-03-01 The Franklin Institute High gradient magnetic separation device
DE3522365A1 (en) * 1985-06-22 1987-01-02 Bayer Ag DISCONNECTOR FOR MAGNETIC PARTICLES FROM LIQUID PHASE
US4664796A (en) * 1985-09-16 1987-05-12 Coulter Electronics, Inc. Flux diverting flow chamber for high gradient magnetic separation of particles from a liquid medium
US4666595A (en) * 1985-09-16 1987-05-19 Coulter Electronics, Inc. Apparatus for acoustically removing particles from a magnetic separation matrix
US4738777A (en) * 1986-06-12 1988-04-19 Amsted Industries Incorporated Pressure filter media mounting assembly
US4770183A (en) * 1986-07-03 1988-09-13 Advanced Magnetics Incorporated Biologically degradable superparamagnetic particles for use as nuclear magnetic resonance imaging agents
DE68919715T2 (en) * 1988-12-28 1995-04-06 Stefan Miltenyi METHOD AND MATERIALS FOR HIGHLY GRADUATED MAGNETIC SPLITTING OF BIOLOGICAL MATERIALS.
US5411730A (en) * 1993-07-20 1995-05-02 Research Corporation Technologies, Inc. Magnetic microparticles

Patent Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1983002405A1 (en) * 1982-01-14 1983-07-21 Reed, Thomas, A. Method and apparatus for separating organic substances from a suspension or a solution
US4452773A (en) * 1982-04-05 1984-06-05 Canadian Patents And Development Limited Magnetic iron-dextran microspheres
EP0125995A2 (en) * 1983-05-12 1984-11-21 Advanced Magnetics, Inc. Magnetic particles for use in separations
US4526681A (en) * 1983-10-31 1985-07-02 Purdue Research Foundation Magnetic separation method utilizing a colloid of magnetic particles
US4677067A (en) * 1984-06-22 1987-06-30 Bio-Magnetech Corporation Magnetotactic bacteria in clinical assay, immunoassay, and cell separation procedures and the like
DE3624626A1 (en) * 1986-07-18 1988-01-28 Pilgrimm Herbert Process for separating off substances from a mixture of substances using magnetic liquids

Non-Patent Citations (4)

* Cited by examiner, † Cited by third party
Title
IBM Technical Disclosure Bulletin, Vol. 19, No. 7, December 1976, (New York, US), M. RONAY: "Addition of Surfactants to Water-Magnetite Suspensions", pages 2760-2763 *
IEEE Transactions on Magnetics, Vol. MAG-22, No. 5, September 1986, IEEE, (New York, US), K. O' GRADY et al.: "Magnetic Filtration of Ferrofluids", pages 1134-1136 *
IEEE Transactions on Magnetics, Volume MAG-18, No. 6, November 1982, IEEE, (New York, US), J.Y. HWANG et al.: "Selective Seeding for Magnetic Separation", pages 1689-1691 *
IEEE Transactions on Magnetics, Volume MAG-20, No. 1, January 1984, IEEE, (New York, US), M. TAKAYASU et al.: "Magnetic Separation Utilizing a Magnetic Susceptibility Gradient", pages 155-159 *

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