WO1991006855A3 - Einmal-biosensor zum nachweis von antigen/antikörperbindungen im vollblut zur anwendung als anti-hiv-bestätigungstest mit verbalem ergebnis auf einer flüssigkeitskristallanzeige - Google Patents

Einmal-biosensor zum nachweis von antigen/antikörperbindungen im vollblut zur anwendung als anti-hiv-bestätigungstest mit verbalem ergebnis auf einer flüssigkeitskristallanzeige Download PDF

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Publication number
WO1991006855A3
WO1991006855A3 PCT/DE1990/000816 DE9000816W WO9106855A3 WO 1991006855 A3 WO1991006855 A3 WO 1991006855A3 DE 9000816 W DE9000816 W DE 9000816W WO 9106855 A3 WO9106855 A3 WO 9106855A3
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Prior art keywords
result
crystal display
liquid crystal
verbal
confirmatory test
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PCT/DE1990/000816
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English (en)
French (fr)
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WO1991006855A2 (de
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Falko Volkhardt Erich Tittel
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Falko Volkhardt Erich Tittel
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Publication of WO1991006855A2 publication Critical patent/WO1991006855A2/de
Publication of WO1991006855A3 publication Critical patent/WO1991006855A3/de

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    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/569—Immunoassay; Biospecific binding assay; Materials therefor for microorganisms, e.g. protozoa, bacteria, viruses
    • G01N33/56983—Viruses
    • G01N33/56988—HIV or HTLV
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/145—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue
    • A61B5/14546—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue for measuring analytes not otherwise provided for, e.g. ions, cytochromes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/145—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue
    • A61B5/1455—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue using optical sensors, e.g. spectral photometrical oximeters
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/15—Devices for taking samples of blood
    • A61B5/150007—Details
    • A61B5/150015—Source of blood
    • A61B5/150022—Source of blood for capillary blood or interstitial fluid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/15—Devices for taking samples of blood
    • A61B5/150007—Details
    • A61B5/150374—Details of piercing elements or protective means for preventing accidental injuries by such piercing elements
    • A61B5/150381—Design of piercing elements
    • A61B5/150412—Pointed piercing elements, e.g. needles, lancets for piercing the skin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/15—Devices for taking samples of blood
    • A61B5/151—Devices specially adapted for taking samples of capillary blood, e.g. by lancets, needles or blades
    • A61B5/15101—Details
    • A61B5/15103—Piercing procedure
    • A61B5/15107—Piercing being assisted by a triggering mechanism
    • A61B5/15109—Fully automatically triggered, i.e. the triggering does not require a deliberate action by the user, e.g. by contact with the patient's skin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/15—Devices for taking samples of blood
    • A61B5/151—Devices specially adapted for taking samples of capillary blood, e.g. by lancets, needles or blades
    • A61B5/15101—Details
    • A61B5/15115—Driving means for propelling the piercing element to pierce the skin, e.g. comprising mechanisms based on shape memory alloys, magnetism, solenoids, piezoelectric effect, biased elements, resilient elements, vacuum or compressed fluids
    • A61B5/15117—Driving means for propelling the piercing element to pierce the skin, e.g. comprising mechanisms based on shape memory alloys, magnetism, solenoids, piezoelectric effect, biased elements, resilient elements, vacuum or compressed fluids comprising biased elements, resilient elements or a spring, e.g. a helical spring, leaf spring, or elastic strap
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/15—Devices for taking samples of blood
    • A61B5/151—Devices specially adapted for taking samples of capillary blood, e.g. by lancets, needles or blades
    • A61B5/15142—Devices intended for single use, i.e. disposable
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/15—Devices for taking samples of blood
    • A61B5/157—Devices characterised by integrated means for measuring characteristics of blood
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2/00—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor
    • A61L2/16—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor using chemical substances
    • A61L2/18—Liquid substances or solutions comprising solids or dissolved gases
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/17—Systems in which incident light is modified in accordance with the properties of the material investigated
    • G01N21/55—Specular reflectivity
    • G01N21/552—Attenuated total reflection
    • G01N21/553—Attenuated total reflection and using surface plasmons
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G01N33/54366—Apparatus specially adapted for solid-phase testing
    • G01N33/54373—Apparatus specially adapted for solid-phase testing involving physiochemical end-point determination, e.g. wave-guides, FETS, gratings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B2560/00—Constructional details of operational features of apparatus; Accessories for medical measuring apparatus
    • A61B2560/02—Operational features
    • A61B2560/0266—Operational features for monitoring or limiting apparatus function
    • A61B2560/028—Arrangements to prevent overuse, e.g. by counting the number of uses
    • A61B2560/0285—Apparatus for single use
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B2562/00—Details of sensors; Constructional details of sensor housings or probes; Accessories for sensors
    • A61B2562/02—Details of sensors specially adapted for in-vivo measurements
    • A61B2562/0233—Special features of optical sensors or probes classified in A61B5/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B2562/00—Details of sensors; Constructional details of sensor housings or probes; Accessories for sensors
    • A61B2562/12—Manufacturing methods specially adapted for producing sensors for in-vivo measurements

Abstract

Bestätigungstest auf einem Siliziumchip, der das ELISA- und WB-Verfahren als Grundlage benutzt. Was bisher chemisch geschah, wird hier physikalisch mit Hilfe von Ultraschall (PZ) (ca. 500-fache Beschleunigung) und dem Oberflächenplasmonresonanzeffekt erreicht. Die Abfrage der 9 Meßstellen (M) erfolgt über Lichtleiter (LB) und Photodioden (A). Das Endergebnis wird über eine logische Schaltung auf einem LCD (L) angezeigt. Im eindeutigen Fall erscheint es dort verbal (z.B. ''Anti-HIV-negativ''), sonst nur als Kodenummer die in einem Begleitdiagnoseheft nachgeschlagen werden kann. Das fertige Gerät ist kleiner als halb so groß wie eine Streichholzschachtel. Das Gerät besitzt zusätzlich eine einfache Punktiereinrichtung, die bei Anwendung als ''Ohrclip'' mit Klammer (Punktion des Ohrläppchens) automatisch nach 3 Minuten das Ergebnis anzeigt. Zur Vermeidung auch nur möglicher Ansteckung werden die im Chip immobilisierten Teilantigene (M) mit einer Desinfektionsflüssigkeit zerstört (nach 10 Minuten).
PCT/DE1990/000816 1989-11-02 1990-10-26 Einmal-biosensor zum nachweis von antigen/antikörperbindungen im vollblut zur anwendung als anti-hiv-bestätigungstest mit verbalem ergebnis auf einer flüssigkeitskristallanzeige WO1991006855A2 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DEP3936442.9 1989-11-02
DE3936442 1989-11-02

Publications (2)

Publication Number Publication Date
WO1991006855A2 WO1991006855A2 (de) 1991-05-16
WO1991006855A3 true WO1991006855A3 (de) 1991-06-27

Family

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Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/DE1990/000816 WO1991006855A2 (de) 1989-11-02 1990-10-26 Einmal-biosensor zum nachweis von antigen/antikörperbindungen im vollblut zur anwendung als anti-hiv-bestätigungstest mit verbalem ergebnis auf einer flüssigkeitskristallanzeige

Country Status (4)

Country Link
EP (1) EP0452439A1 (de)
JP (1) JPH04502671A (de)
DE (1) DE4033741C2 (de)
WO (1) WO1991006855A2 (de)

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US8690798B2 (en) 1996-05-17 2014-04-08 Roche Diagnostics Operations, Inc. Methods and apparatus for sampling and analyzing body fluid
US9445756B2 (en) 2005-03-02 2016-09-20 Roche Diabetes Care, Inc. Dynamic integrated lancing test strip with sterility cover

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US5623070A (en) * 1990-07-27 1997-04-22 Isis Pharmaceuticals, Inc. Heteroatomic oligonucleoside linkages
CA2102884A1 (en) * 1993-03-04 1994-09-05 James J. Wynne Dental procedures and apparatus using ultraviolet radiation
DE4315211A1 (de) * 1993-05-07 1994-02-03 Gunnar Brink Vorrichtung und Verfahren zum Nachweis der Adsorption von Molekülen mittels Nahinfrarot-Oberflächenplasmonenresonanz
US20020010406A1 (en) 1996-05-17 2002-01-24 Douglas Joel S. Methods and apparatus for expressing body fluid from an incision
EP1189281B1 (de) * 1998-06-30 2007-08-22 Micronas GmbH Chip-Anordnung
DE19836110C2 (de) * 1998-08-10 2002-07-11 Jandratek Gmbh Sensorvorrichtung mit einer Mischeinrichtung
DE19836109A1 (de) * 1998-08-10 2000-03-02 Biotul Bio Instr Gmbh Vorrichtung und Verfahren zur grenzflächennahen Mischung von Proben in Biosensorsystemen
IL135076A0 (en) * 2000-03-15 2001-05-20 Zilber Gil An immunoassay diagnostic probe and a method for use thereof
DE10134650B4 (de) 2001-07-20 2009-12-03 Roche Diagnostics Gmbh System zur Entnahme kleiner Körperflüssigkeitsmengen
NZ528338A (en) * 2004-03-19 2006-10-27 Ind Res Ltd Biosensors for detecting bond rupture
EP1659404A1 (de) * 2004-11-17 2006-05-24 Valtronic S.A. Autonomous miniaturised diagnostic device
US8366652B2 (en) 2007-08-17 2013-02-05 The Invention Science Fund I, Llc Systems, devices, and methods including infection-fighting and monitoring shunts
US8029740B2 (en) 2008-07-11 2011-10-04 The Invention Science Fund I, Llc Event-triggered self-sterilization of article surfaces
US8706211B2 (en) 2007-08-17 2014-04-22 The Invention Science Fund I, Llc Systems, devices, and methods including catheters having self-cleaning surfaces
US8114346B2 (en) 2007-08-17 2012-02-14 The Invention Science Fund I, Llc Event-triggered ultraviolet light sterilization of surfaces
US8734718B2 (en) 2007-08-17 2014-05-27 The Invention Science Fund I, Llc Systems, devices, and methods including catheters having an actively controllable therapeutic agent delivery component
US8702640B2 (en) 2007-08-17 2014-04-22 The Invention Science Fund I, Llc System, devices, and methods including catheters configured to monitor and inhibit biofilm formation
US8753304B2 (en) 2007-08-17 2014-06-17 The Invention Science Fund I, Llc Systems, devices, and methods including catheters having acoustically actuatable waveguide components for delivering a sterilizing stimulus to a region proximate a surface of the catheter
US8647292B2 (en) 2007-08-17 2014-02-11 The Invention Science Fund I, Llc Systems, devices, and methods including catheters having components that are actively controllable between two or more wettability states
US20090048648A1 (en) * 2007-08-17 2009-02-19 Searete Llc, A Limited Liability Corporation Of The State Of Delaware Self-sterilizing device
US8162924B2 (en) 2007-08-17 2012-04-24 The Invention Science Fund I, Llc System, devices, and methods including actively-controllable superoxide water generating systems
US8460229B2 (en) 2007-08-17 2013-06-11 The Invention Science Fund I, Llc Systems, devices, and methods including catheters having components that are actively controllable between transmissive and reflective states
US9005263B2 (en) 2007-08-17 2015-04-14 The Invention Science Fund I, Llc System, devices, and methods including actively-controllable sterilizing excitation delivery implants
JP5487200B2 (ja) * 2008-04-23 2014-05-07 ソシエテ ドゥ コメルシャリザシオン デ プロデュイ ドゥ ラ ルシェルシェ アプリケ−ソクプラ−シャーンス エ ジェニ エス．ウー．セー． せん断垂直弾性表面波一体型表面プラズモン共鳴センシング装置および方法
US20110295088A1 (en) 2008-12-04 2011-12-01 Searete Llc, A Limited Liability Corporation Of The State Of Delaware Systems, devices, and methods including implantable devices with anti-microbial properties
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US9445756B2 (en) 2005-03-02 2016-09-20 Roche Diabetes Care, Inc. Dynamic integrated lancing test strip with sterility cover

Also Published As

Publication number Publication date
EP0452439A1 (de) 1991-10-23
JPH04502671A (ja) 1992-05-14
DE4033741C2 (de) 1994-03-31
WO1991006855A2 (de) 1991-05-16
DE4033741A1 (de) 1991-05-08

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