WO1991008298A3 - Fusion proteins consisting of a ligand binding protein and a stable plasma protein - Google Patents

Fusion proteins consisting of a ligand binding protein and a stable plasma protein Download PDF

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Publication number
WO1991008298A3
WO1991008298A3 PCT/US1990/006849 US9006849W WO9108298A3 WO 1991008298 A3 WO1991008298 A3 WO 1991008298A3 US 9006849 W US9006849 W US 9006849W WO 9108298 A3 WO9108298 A3 WO 9108298A3
Authority
WO
WIPO (PCT)
Prior art keywords
fusion proteins
protein
ligand binding
stable plasma
proteins consisting
Prior art date
Application number
PCT/US1990/006849
Other languages
French (fr)
Other versions
WO1991008298A2 (en
Inventor
Daniel J Capon
Laurence A Lasky
Original Assignee
Genentech Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=23749509&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=WO1991008298(A3) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Genentech Inc filed Critical Genentech Inc
Priority to DE69033705T priority Critical patent/DE69033705T3/en
Priority to DK99123412T priority patent/DK1029870T3/en
Priority to EP91901202A priority patent/EP0526452B2/en
Priority to DK91901202T priority patent/DK0526452T4/en
Priority to CA002072642A priority patent/CA2072642C/en
Priority to AT91901202T priority patent/ATE199261T1/en
Publication of WO1991008298A2 publication Critical patent/WO1991008298A2/en
Publication of WO1991008298A3 publication Critical patent/WO1991008298A3/en
Priority to HK98114595A priority patent/HK1013298A1/en
Priority to GR20010400708T priority patent/GR3035856T3/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/62—DNA sequences coding for fusion proteins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70503—Immunoglobulin superfamily
    • C07K14/70514—CD4
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
    • C07K2319/02—Fusion polypeptide containing a localisation/targetting motif containing a signal sequence
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
    • C07K2319/04—Fusion polypeptide containing a localisation/targetting motif containing an ER retention signal such as a C-terminal HDEL motif
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/30—Non-immunoglobulin-derived peptide or protein having an immunoglobulin constant or Fc region, or a fragment thereof, attached thereto
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/32—Fusion polypeptide fusions with soluble part of a cell surface receptor, "decoy receptors"
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/33—Fusion polypeptide fusions for targeting to specific cell types, e.g. tissue specific targeting, targeting of a bacterial subspecies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/70—Fusion polypeptide containing domain for protein-protein interaction
    • C07K2319/705—Fusion polypeptide containing domain for protein-protein interaction containing a protein-A fusion

Abstract

Novel peptides are provided, together with methods for making and using them, and nucleic acids encoding them. These peptides are useful as cell surface adhesion molecules and ligands, and are useful in therapeutic or diagnostic compositions and methods.
PCT/US1990/006849 1989-11-22 1990-11-21 Fusion proteins consisting of a ligand binding protein and a stable plasma protein WO1991008298A2 (en)

Priority Applications (8)

Application Number Priority Date Filing Date Title
DE69033705T DE69033705T3 (en) 1989-11-22 1990-11-21 HYBRID IMMUNOGLOBULINE
DK99123412T DK1029870T3 (en) 1989-11-22 1990-11-21 Hybrid immunoglobulins for use in therapeutic methods
EP91901202A EP0526452B2 (en) 1989-11-22 1990-11-21 Hybrid immunoglobulins
DK91901202T DK0526452T4 (en) 1989-11-22 1990-11-21 hybrid immunoglobulin
CA002072642A CA2072642C (en) 1989-11-22 1990-11-21 Fusion proteins consisting of a ligand binding protein and a stable plasma protein
AT91901202T ATE199261T1 (en) 1989-11-22 1990-11-21 HYBRID IMMUNOLOBULINS
HK98114595A HK1013298A1 (en) 1989-11-22 1998-12-22 Hybrid immunoglobulins
GR20010400708T GR3035856T3 (en) 1989-11-22 2001-05-11 Hybrid immunoglobulins.

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US07/440,625 US5116964A (en) 1989-02-23 1989-11-22 Hybrid immunoglobulins
US440,625 1989-11-22

Publications (2)

Publication Number Publication Date
WO1991008298A2 WO1991008298A2 (en) 1991-06-13
WO1991008298A3 true WO1991008298A3 (en) 1991-10-17

Family

ID=23749509

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US1990/006849 WO1991008298A2 (en) 1989-11-22 1990-11-21 Fusion proteins consisting of a ligand binding protein and a stable plasma protein

Country Status (13)

Country Link
US (1) US5116964A (en)
EP (3) EP1970386A2 (en)
JP (2) JPH05503009A (en)
AT (2) ATE396735T1 (en)
CA (1) CA2072642C (en)
DE (3) DE69034253D1 (en)
DK (2) DK1029870T3 (en)
ES (2) ES2308826T3 (en)
GR (1) GR3035856T3 (en)
HK (2) HK1013298A1 (en)
LU (1) LU91498I2 (en)
NL (1) NL300372I1 (en)
WO (1) WO1991008298A2 (en)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8691952B2 (en) 2005-12-30 2014-04-08 Merck Patent Gmbh Anti-CD19 antibodies with reduced immunogenicity
US9114175B2 (en) 2005-08-12 2015-08-25 Amgen Inc. Modified Fc molecules

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* Cited by examiner, † Cited by third party
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