WO1992002534A3 - Compounds and methods for inhibiting gene expression - Google Patents
Compounds and methods for inhibiting gene expression Download PDFInfo
- Publication number
- WO1992002534A3 WO1992002534A3 PCT/US1991/005531 US9105531W WO9202534A3 WO 1992002534 A3 WO1992002534 A3 WO 1992002534A3 US 9105531 W US9105531 W US 9105531W WO 9202534 A3 WO9202534 A3 WO 9202534A3
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- compounds
- methods
- gene expression
- inhibiting gene
- bases
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
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- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- Organic Chemistry (AREA)
- Genetics & Genomics (AREA)
- General Health & Medical Sciences (AREA)
- Biotechnology (AREA)
- Engineering & Computer Science (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Saccharide Compounds (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Golf Clubs (AREA)
- Adhesives Or Adhesive Processes (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
Priority Applications (11)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE69115702T DE69115702T2 (en) | 1990-08-03 | 1991-08-02 | CONNECTIONS AND METHOD FOR SUPPRESSING GENE EXPRESSION |
AU85217/91A AU667459B2 (en) | 1990-08-03 | 1991-08-02 | Compounds and methods for inhibiting gene expression |
JP3515616A JPH06502300A (en) | 1990-08-03 | 1991-08-02 | Compounds and methods for suppressing gene expression |
RU93005077A RU2131436C1 (en) | 1990-09-13 | 1991-08-02 | Nuclease-resistant oligonucleosides, method of preparing thereof, and nuclease-resistant nucleoside dimer |
KR1019930700317A KR100211552B1 (en) | 1990-08-03 | 1991-08-02 | Compounds and methods for inhibiting gene expression |
BR919106729A BR9106729A (en) | 1990-08-03 | 1991-08-02 | COMPOUND, PROCESSES TO INHIBIT NUCLEASE DEGRADATION OF COMPOUNDS AND TO STABILIZE SEQUENCES OF NICLEOTIDEOS OR OLIGONUCLEOSIDEOS, COMPOSITION USABLE TO INHIBIT GENE EXPRESSION AND PROCESS TO INHIBIT EXPRESSION OF GENES IN A NEEDING MAMMALIAN NEEDING NEEDS |
EP91916390A EP0541722B1 (en) | 1990-08-03 | 1991-08-02 | Compounds and methods for inhibiting gene expression |
NO93930358A NO930358L (en) | 1990-08-03 | 1993-02-02 | RELATIONS AND PROCEDURES FOR INHIBITING GENEPRESSION |
FI930455A FI930455A (en) | 1990-08-03 | 1993-02-02 | FOERENINGAR OCH FOERFARANDEN FOER INHIBERING AV GEN EXPRESSION |
GR960400275T GR3018881T3 (en) | 1990-08-03 | 1996-02-01 | Compounds and methods for inhibiting gene expression |
FI964173A FI964173A0 (en) | 1990-08-03 | 1996-10-17 | Process for the preparation of therapeutically useful modified oligonucleotide compounds |
Applications Claiming Priority (10)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US562,180 | 1990-08-03 | ||
US07/562,180 US5245022A (en) | 1990-08-03 | 1990-08-03 | Exonuclease resistant terminally substituted oligonucleotides |
US58245690A | 1990-09-13 | 1990-09-13 | |
US58245790A | 1990-09-13 | 1990-09-13 | |
US58228790A | 1990-09-13 | 1990-09-13 | |
US582,456 | 1990-09-13 | ||
US582,287 | 1990-09-13 | ||
US582,457 | 1990-09-13 | ||
US68278491A | 1991-04-09 | 1991-04-09 | |
US682,784 | 1991-04-09 |
Publications (2)
Publication Number | Publication Date |
---|---|
WO1992002534A2 WO1992002534A2 (en) | 1992-02-20 |
WO1992002534A3 true WO1992002534A3 (en) | 1992-06-11 |
Family
ID=27541908
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/US1991/005531 WO1992002534A2 (en) | 1990-08-03 | 1991-08-02 | Compounds and methods for inhibiting gene expression |
Country Status (20)
Country | Link |
---|---|
US (1) | US5677439A (en) |
EP (1) | EP0541722B1 (en) |
JP (1) | JPH06502300A (en) |
KR (1) | KR100211552B1 (en) |
AT (1) | ATE131827T1 (en) |
AU (2) | AU667459B2 (en) |
BR (1) | BR9106729A (en) |
CA (1) | CA2088673A1 (en) |
DE (1) | DE69115702T2 (en) |
DK (1) | DK0541722T3 (en) |
ES (1) | ES2083593T3 (en) |
FI (1) | FI930455A (en) |
GR (1) | GR3018881T3 (en) |
HU (2) | HU217036B (en) |
IL (3) | IL113519A (en) |
MY (1) | MY107332A (en) |
NZ (1) | NZ239247A (en) |
PT (1) | PT98562B (en) |
TW (1) | TW222641B (en) |
WO (1) | WO1992002534A2 (en) |
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US5138045A (en) * | 1990-07-27 | 1992-08-11 | Isis Pharmaceuticals | Polyamine conjugated oligonucleotides |
US5378825A (en) * | 1990-07-27 | 1995-01-03 | Isis Pharmaceuticals, Inc. | Backbone modified oligonucleotide analogs |
US5223618A (en) * | 1990-08-13 | 1993-06-29 | Isis Pharmaceuticals, Inc. | 4'-desmethyl nucleoside analog compounds |
US5489677A (en) * | 1990-07-27 | 1996-02-06 | Isis Pharmaceuticals, Inc. | Oligonucleoside linkages containing adjacent oxygen and nitrogen atoms |
IL113519A (en) * | 1990-08-03 | 1997-11-20 | Sterling Winthrop Inc | Oligonucleoside sequences of from about 6 to about 200 bases having a three atom internucleoside linkage, their preparation and pharmaceutical compositions for inhibiting gene expression containing said oligonucleosides |
US5245022A (en) * | 1990-08-03 | 1993-09-14 | Sterling Drug, Inc. | Exonuclease resistant terminally substituted oligonucleotides |
US5214134A (en) * | 1990-09-12 | 1993-05-25 | Sterling Winthrop Inc. | Process of linking nucleosides with a siloxane bridge |
US5389023A (en) * | 1993-03-22 | 1995-02-14 | Mcintyre; Jonothon M. W. | Body surfing board |
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PT98562A (en) | 1992-06-30 |
TW222641B (en) | 1994-04-21 |
JPH06502300A (en) | 1994-03-17 |
HU217036B (en) | 1999-11-29 |
EP0541722A1 (en) | 1993-05-19 |
IL99066A (en) | 1996-01-31 |
ES2083593T3 (en) | 1996-04-16 |
AU2008195A (en) | 1995-10-12 |
HU211668A9 (en) | 1995-12-28 |
BR9106729A (en) | 1993-07-20 |
GR3018881T3 (en) | 1996-05-31 |
MY107332A (en) | 1995-11-30 |
DK0541722T3 (en) | 1996-04-22 |
EP0541722B1 (en) | 1995-12-20 |
AU667459B2 (en) | 1996-03-28 |
NZ239247A (en) | 1993-11-25 |
HU9300282D0 (en) | 1993-04-28 |
IL121421A0 (en) | 1998-01-04 |
ATE131827T1 (en) | 1996-01-15 |
KR100211552B1 (en) | 1999-08-02 |
KR930702372A (en) | 1993-09-08 |
WO1992002534A2 (en) | 1992-02-20 |
US5677439A (en) | 1997-10-14 |
DE69115702T2 (en) | 1996-06-13 |
AU8521791A (en) | 1992-03-02 |
FI930455A0 (en) | 1993-02-02 |
DE69115702D1 (en) | 1996-02-01 |
FI930455A (en) | 1993-03-24 |
HUT67834A (en) | 1995-05-29 |
IL99066A0 (en) | 1992-07-15 |
AU692532B2 (en) | 1998-06-11 |
PT98562B (en) | 1999-01-29 |
IL113519A (en) | 1997-11-20 |
CA2088673A1 (en) | 1992-02-04 |
IL113519A0 (en) | 1995-07-31 |
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