WO1992017184A3 - Bioactive topical siloxane compositions having enhanced performance and safety - Google Patents

Bioactive topical siloxane compositions having enhanced performance and safety Download PDF

Info

Publication number
WO1992017184A3
WO1992017184A3 PCT/US1992/000537 US9200537W WO9217184A3 WO 1992017184 A3 WO1992017184 A3 WO 1992017184A3 US 9200537 W US9200537 W US 9200537W WO 9217184 A3 WO9217184 A3 WO 9217184A3
Authority
WO
WIPO (PCT)
Prior art keywords
skin
safety
agent
bioactive agents
bioactive
Prior art date
Application number
PCT/US1992/000537
Other languages
French (fr)
Other versions
WO1992017184A2 (en
Inventor
David N Haney
Original Assignee
Special Advanced Biomaterials
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Special Advanced Biomaterials filed Critical Special Advanced Biomaterials
Priority to JP4505414A priority Critical patent/JPH06507385A/en
Publication of WO1992017184A2 publication Critical patent/WO1992017184A2/en
Publication of WO1992017184A3 publication Critical patent/WO1992017184A3/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/695—Silicon compounds
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N25/00—Biocides, pest repellants or attractants, or plant growth regulators, characterised by their forms, or by their non-active ingredients or by their methods of application, e.g. seed treatment or sequential application; Substances for reducing the noxious effect of the active ingredients to organisms other than pests
    • A01N25/24—Biocides, pest repellants or attractants, or plant growth regulators, characterised by their forms, or by their non-active ingredients or by their methods of application, e.g. seed treatment or sequential application; Substances for reducing the noxious effect of the active ingredients to organisms other than pests containing ingredients to enhance the sticking of the active ingredients
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/34—Macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyesters, polyamino acids, polysiloxanes, polyphosphazines, copolymers of polyalkylene glycol or poloxamers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/52—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an inorganic compound, e.g. an inorganic ion that is complexed with the active ingredient
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
    • A61K8/36—Carboxylic acids; Salts or anhydrides thereof
    • A61K8/368—Carboxylic acids; Salts or anhydrides thereof with carboxyl groups directly bound to carbon atoms of aromatic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/46—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing sulfur
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/58—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing atoms other than carbon, hydrogen, halogen, oxygen, nitrogen, sulfur or phosphorus
    • A61K8/585—Organosilicon compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/64—Proteins; Peptides; Derivatives or degradation products thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
    • A61K8/84—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds obtained by reactions otherwise than those involving only carbon-carbon unsaturated bonds
    • A61K8/89—Polysiloxanes
    • A61K8/891—Polysiloxanes saturated, e.g. dimethicone, phenyl trimethicone, C24-C28 methicone or stearyl dimethicone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q5/00—Preparations for care of the hair
    • A61Q5/12—Preparations containing hair conditioners
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
    • A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
    • A61K2800/57—Compounds covalently linked to a(n inert) carrier molecule, e.g. conjugates, pro-fragrances
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
    • A61K2800/80—Process related aspects concerning the preparation of the cosmetic composition or the storage or application thereof
    • A61K2800/94—Involves covalent bonding to the substrate
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S424/00—Drug, bio-affecting and body treating compositions
    • Y10S424/10—Insect repellent

Abstract

Methods and compositions that provide for the long-term adhesion and slow-release of various bioactive agents on the surface of human skin utilize siloxane bridging agents activated for reaction with the skin surface which bind the bioactive agent to the skin surface. Since the topical agent remains bound to the continuously renewing epidermis, safety is enhanced for many bioactive agents. Slight modifications of the siloxane bridging compounds or bioactive agents allows for more or less adhesion to the skin, controlling the degree of release of the agent. Skin treatments according to the invention can provide enhanced repellency to microorganisms, insect bites, sun, water, poison ivy/oak, and other skin irritants, and other effects such as artificial skin coloring and administration of topical drugs, among others.
PCT/US1992/000537 1991-03-27 1992-01-22 Bioactive topical siloxane compositions having enhanced performance and safety WO1992017184A2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP4505414A JPH06507385A (en) 1991-03-27 1992-01-22 Topical bioactive siloxane compositions with improved efficacy and stability

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US07/675,749 US5686065A (en) 1991-03-27 1991-03-27 Topical siloxane sunscreen compositions having enhanced performance and safety
US675,749 1991-03-27

Publications (2)

Publication Number Publication Date
WO1992017184A2 WO1992017184A2 (en) 1992-10-15
WO1992017184A3 true WO1992017184A3 (en) 1992-12-10

Family

ID=24711820

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US1992/000537 WO1992017184A2 (en) 1991-03-27 1992-01-22 Bioactive topical siloxane compositions having enhanced performance and safety

Country Status (4)

Country Link
US (2) US5686065A (en)
JP (1) JPH06507385A (en)
AU (1) AU1263592A (en)
WO (1) WO1992017184A2 (en)

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US5540920A (en) * 1994-11-22 1996-07-30 Olin Corporation Synergistic biocide composition containing pyrithione plus an additive
US5948391A (en) * 1998-03-16 1999-09-07 Petroferm Inc Silicone salicylate esters in personal care
US6277364B1 (en) 1998-10-09 2001-08-21 Bertek Pharmaceuticals, Inc. Polyurethanes as topical skin protectants
FR2800073B1 (en) * 1999-10-26 2001-11-23 Oreal NOVEL SILICATED COMPOUNDS DERIVED FROM ASCORBIC ACID, PROCESS FOR THEIR PREPARATION, COMPOSITIONS COMPRISING SAME AND USES THEREOF
JP2003516952A (en) * 1999-12-14 2003-05-20 ユニリーバー・ナームローゼ・ベンノートシヤープ Skin conditioning cosmetic composition containing red yeast rice extract
JP2003527168A (en) 1999-12-28 2003-09-16 キンバリー クラーク ワールドワイド インコーポレイテッド Controlled release antimicrobial wipes for hard surfaces
AU774993B2 (en) 1999-12-28 2004-07-15 Kimberly-Clark Worldwide, Inc. Use-dependent indicator system for absorbent articles
JP2004525121A (en) * 2001-03-07 2004-08-19 ザ プロクター アンド ギャンブル カンパニー Topical compositions containing functionalized anhydride-based cosmetic binders
CA2448575A1 (en) * 2001-03-07 2002-09-19 The Procter & Gamble Company Topical composition comprising a functionally acylating cosmetic bonding agent
EP1377272A2 (en) * 2001-03-07 2004-01-07 The Procter & Gamble Company Topical composition comprising a 1, 2-heteroatom constituted diene cosmetic bonding agent
EP1370234A2 (en) * 2001-03-07 2003-12-17 The Procter & Gamble Company Topical composition comprising a cyclic imidocarbonate-based cosmetic bonding agent
WO2002072059A2 (en) * 2001-03-07 2002-09-19 The Procter & Gamble Company Topical composition comprising a functionally alkylating cosmetic bonding agent
CN1496249A (en) * 2001-03-07 2004-05-12 Topical composition comprising three membered cyclic compound-based cosmetic bonding agent
JP2004520428A (en) * 2001-03-07 2004-07-08 ザ プロクター アンド ギャンブル カンパニー Topical compositions containing cosmetic binders based on diazonium salts
MXPA03008108A (en) * 2001-03-07 2003-12-12 Procter & Gamble Topical composition comprising a functional aromatic derivative cosmetic bonding agent.
CN1529582A (en) * 2001-03-07 2004-09-15 Topitial composition comprising aldehyde or ketone-based cosmetic bonding agent
EP1392235A2 (en) * 2001-05-30 2004-03-03 The Procter & Gamble Company Topical composition comprising an activated, trans-structured cosmetic bonding agent
EP1392236A2 (en) * 2001-05-30 2004-03-03 The Procter & Gamble Company Topical cosmetic composition comprising an alpha-beta-unsaturated ester as bonding agent
AR043050A1 (en) 2002-09-26 2005-07-13 Rib X Pharmaceuticals Inc BIFunctional HETEROCICLICAL COMPOUNDS AND METHODS TO PREPARE AND USE THE SAME
US20040120915A1 (en) * 2002-12-19 2004-06-24 Kaiyuan Yang Multifunctional compositions for surface applications
US8202843B2 (en) 2004-02-27 2012-06-19 Rib-X Pharmaceuticals, Inc. Macrocyclic compounds and methods of making and using the same
US20060004185A1 (en) 2004-07-01 2006-01-05 Leese Richard A Peptide antibiotics and peptide intermediates for their prepartion
GB0506141D0 (en) * 2005-03-24 2005-05-04 Transphase Ltd A topical compostion and its uses
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US7964245B2 (en) * 2008-06-27 2011-06-21 Hallstar Innovations Corp. UV-absorbing and photostabilizing polymers
CA2747995A1 (en) 2008-12-23 2010-07-01 Biosource Pharm, Inc. Antibiotic compositions for the treatment of gram negative infections
EP2512416A2 (en) * 2009-12-18 2012-10-24 L'Oréal Cosmetic treatment method involving a compound capable of condensing in situ
US8415307B1 (en) 2010-06-23 2013-04-09 Biosource Pharm, Inc. Antibiotic compositions for the treatment of gram negative infections
US8765110B2 (en) * 2010-12-30 2014-07-01 L'oreal Composition containing an alkoxysilane and hyaluronic acid
US8747868B2 (en) 2010-12-30 2014-06-10 L'oreal Reaction product of a polar modified polymer and an alkoxysilane and a composition containing the reaction product
EP3851161A1 (en) 2015-10-15 2021-07-21 DUSA Pharmaceuticals, Inc. Adjustable illuminator for photodynamic therapy and diagnosis
US10603508B2 (en) 2015-10-15 2020-03-31 Dusa Pharmaceuticals, Inc. Adjustable illuminators and methods for photodynamic therapy and diagnosis
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Also Published As

Publication number Publication date
AU1263592A (en) 1992-11-02
US5686065A (en) 1997-11-11
US5891914A (en) 1999-04-06
JPH06507385A (en) 1994-08-25
WO1992017184A2 (en) 1992-10-15

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