WO1992019843A3 - Organ preservation apparatus - Google Patents

Organ preservation apparatus Download PDF

Info

Publication number
WO1992019843A3
WO1992019843A3 PCT/US1992/003237 US9203237W WO9219843A3 WO 1992019843 A3 WO1992019843 A3 WO 1992019843A3 US 9203237 W US9203237 W US 9203237W WO 9219843 A3 WO9219843 A3 WO 9219843A3
Authority
WO
WIPO (PCT)
Prior art keywords
organ
receiving chamber
pump
pulsatile pump
fluid
Prior art date
Application number
PCT/US1992/003237
Other languages
French (fr)
Other versions
WO1992019843A2 (en
Inventor
Samuel C Mcghee
C Lester Mcghee
Original Assignee
Trans Med Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Trans Med Corp filed Critical Trans Med Corp
Priority to DE69220938T priority Critical patent/DE69220938T2/en
Priority to EP92913648A priority patent/EP0581897B1/en
Priority to AU21537/92A priority patent/AU668869B2/en
Priority to CA002108890A priority patent/CA2108890A1/en
Publication of WO1992019843A2 publication Critical patent/WO1992019843A2/en
Publication of WO1992019843A3 publication Critical patent/WO1992019843A3/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N1/00—Preservation of bodies of humans or animals, or parts thereof
    • A01N1/02—Preservation of living parts
    • A01N1/0236—Mechanical aspects
    • A01N1/0242—Apparatuses, i.e. devices used in the process of preservation of living parts, such as pumps, refrigeration devices or any other devices featuring moving parts and/or temperature controlling components
    • A01N1/0247—Apparatuses, i.e. devices used in the process of preservation of living parts, such as pumps, refrigeration devices or any other devices featuring moving parts and/or temperature controlling components for perfusion, i.e. for circulating fluid through organs, blood vessels or other living parts
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N1/00—Preservation of bodies of humans or animals, or parts thereof
    • A01N1/02—Preservation of living parts
    • F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
    • F25—REFRIGERATION OR COOLING; COMBINED HEATING AND REFRIGERATION SYSTEMS; HEAT PUMP SYSTEMS; MANUFACTURE OR STORAGE OF ICE; LIQUEFACTION SOLIDIFICATION OF GASES
    • F25D—REFRIGERATORS; COLD ROOMS; ICE-BOXES; COOLING OR FREEZING APPARATUS NOT OTHERWISE PROVIDED FOR
    • F25D3/00—Devices using other cold materials; Devices using cold-storage bodies
    • F25D3/02—Devices using other cold materials; Devices using cold-storage bodies using ice, e.g. ice-boxes
    • F25D3/06—Movable containers
    • F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
    • F25—REFRIGERATION OR COOLING; COMBINED HEATING AND REFRIGERATION SYSTEMS; HEAT PUMP SYSTEMS; MANUFACTURE OR STORAGE OF ICE; LIQUEFACTION SOLIDIFICATION OF GASES
    • F25D—REFRIGERATORS; COLD ROOMS; ICE-BOXES; COOLING OR FREEZING APPARATUS NOT OTHERWISE PROVIDED FOR
    • F25D2303/00—Details of devices using other cold materials; Details of devices using cold-storage bodies
    • F25D2303/08—Devices using cold storage material, i.e. ice or other freezable liquid
    • F25D2303/081—Devices using cold storage material, i.e. ice or other freezable liquid using ice cubes or crushed ice
    • F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
    • F25—REFRIGERATION OR COOLING; COMBINED HEATING AND REFRIGERATION SYSTEMS; HEAT PUMP SYSTEMS; MANUFACTURE OR STORAGE OF ICE; LIQUEFACTION SOLIDIFICATION OF GASES
    • F25D—REFRIGERATORS; COLD ROOMS; ICE-BOXES; COOLING OR FREEZING APPARATUS NOT OTHERWISE PROVIDED FOR
    • F25D2331/00—Details or arrangements of other cooling or freezing apparatus not provided for in other groups of this subclass
    • F25D2331/80—Type of cooled receptacles
    • F25D2331/804—Boxes

Abstract

An organ preservation apparatus (10) including an organ-receiving chamber (12), a pulsatile pump (14) in continuous uninterrupted liquid communication with the organ-receiving chamber (12), and a fluid delivery tube (16) interconnected between the organ-receiving chamber (12) and the pulsatile pump (14). The pulsatile pump (14) is configured to pass an organ preservation fluid to the organ-receiving chamber (12) in a dichrotic pulse pattern. The organ-receiving chamber has an outer box (18) with an insulated interior area (22), an organ-receiving cassette (20) removably contained within the insulated interior area, and a lid (22) detachably fastened to the outer box (18). The pulsatile pump (14) includes a bladder pump (80), a motor (72), and a cam connected to the motor (72). The cam is connected to an actuator so as to compress the bladder pump (80) in a dichrotic pulse pattern. A pressure transducer is connected to the fluid passageway between the pulsatile pump (14) and the organ-receiving chamber (12) so as to measure diastolic and systolic fluid pressure.
PCT/US1992/003237 1991-04-22 1992-04-20 Organ preservation apparatus WO1992019843A2 (en)

Priority Applications (4)

Application Number Priority Date Filing Date Title
DE69220938T DE69220938T2 (en) 1991-04-22 1992-04-20 DEVICE FOR THE STORAGE OF ORGANS
EP92913648A EP0581897B1 (en) 1991-04-22 1992-04-20 Organ preservation apparatus
AU21537/92A AU668869B2 (en) 1991-04-22 1992-04-20 Organ preservation apparatus
CA002108890A CA2108890A1 (en) 1991-04-22 1992-04-20 Organ preservation apparatus

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US07/688,973 US5157930A (en) 1991-04-22 1991-04-22 Organ preservation apparatus
US688,973 1991-04-22

Publications (2)

Publication Number Publication Date
WO1992019843A2 WO1992019843A2 (en) 1992-11-12
WO1992019843A3 true WO1992019843A3 (en) 1993-02-04

Family

ID=24766555

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US1992/003237 WO1992019843A2 (en) 1991-04-22 1992-04-20 Organ preservation apparatus

Country Status (7)

Country Link
US (1) US5157930A (en)
EP (1) EP0581897B1 (en)
AU (1) AU668869B2 (en)
CA (1) CA2108890A1 (en)
DE (1) DE69220938T2 (en)
ES (1) ES2108123T3 (en)
WO (1) WO1992019843A2 (en)

Cited By (1)

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US8962303B2 (en) 1998-09-29 2015-02-24 Lifeline Scientific, Inc. Apparatus and method for maintaining and/or restoring viability of organs

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US5723282A (en) * 1991-07-08 1998-03-03 The American National Red Cross Method of preparing organs for vitrification
US5586438A (en) * 1995-03-27 1996-12-24 Organ, Inc. Portable device for preserving organs by static storage or perfusion
US8409846B2 (en) 1997-09-23 2013-04-02 The United States Of America As Represented By The Department Of Veteran Affairs Compositions, methods and devices for maintaining an organ
US6673594B1 (en) 1998-09-29 2004-01-06 Organ Recovery Systems Apparatus and method for maintaining and/or restoring viability of organs
CA2342944A1 (en) 1998-09-29 2000-04-06 Organ Recovery Systems, Inc. Apparatus and method for maintaining and/or restoring viability of organs
US7749693B2 (en) * 1998-09-29 2010-07-06 Lifeline Scientific, Inc. Method of determining that an organ is not suitable for transplantation and using it for testing substances
US6794182B2 (en) 2000-03-13 2004-09-21 E. George Wolf, Jr. Hyperbaric oxygen organ preservation system (HOOPS)
DE60237932D1 (en) * 2001-08-28 2010-11-18 Mitsubishi Rayon Co Method and device for producing an artificial sparkling water
US6677150B2 (en) * 2001-09-14 2004-01-13 Organ Transport Systems, Inc. Organ preservation apparatus and methods
US6803227B2 (en) * 2001-10-16 2004-10-12 Supachill Technologies Pty. Ltd. Organ preservation system including articles comprising a super-coolable composition having long-duration phase change capability
US7572622B2 (en) * 2002-08-14 2009-08-11 Transmedic, Inc. Heart preservation chamber
US8361091B2 (en) * 2002-08-23 2013-01-29 Organ Recovery Systems, Inc. Cannulas, cannula mount assemblies, and clamping methods using such cannulas and cannula mount assemblies
US20040170950A1 (en) * 2002-09-12 2004-09-02 Prien Samuel D. Organ preservation apparatus and methods
US8128740B2 (en) * 2003-04-04 2012-03-06 Organ Recovery Systems, Inc. Device for separating gas from a liquid path
US7691622B2 (en) * 2003-04-04 2010-04-06 Lifeline Scientific, Inc. Method and apparatus for transferring heat to or from an organ or tissue container
US7897327B2 (en) * 2003-06-02 2011-03-01 Organ Recovery Systems, Inc. Method and apparatus for pressure control for maintaining viability of organs
US20050136125A1 (en) * 2003-10-22 2005-06-23 Roth Mark B. Methods, compositions and devices for inducing stasis in cells, tissues, organs, and organisms
US20050170019A1 (en) * 2003-10-22 2005-08-04 Fred Hutchinson Cancer Research Center Methods, compositions and devices for inducing stasis in cells
WO2005041655A1 (en) * 2003-10-22 2005-05-12 Fred Hutchinson Cancer Research Center Methods, compositions and devices for inducing stasis in cells, tissues, organs, and organisms
US20050153271A1 (en) * 2004-01-13 2005-07-14 Wenrich Marshall S. Organ preservation apparatus and methods
US7504201B2 (en) 2004-04-05 2009-03-17 Organ Recovery Systems Method for perfusing an organ and for isolating cells from the organ
NZ746484A (en) 2004-10-07 2020-04-24 Transmedics Inc Systems and methods for ex-vivo organ care
US8304181B2 (en) 2004-10-07 2012-11-06 Transmedics, Inc. Method for ex-vivo organ care and for using lactate as an indication of donor organ status
US9301519B2 (en) 2004-10-07 2016-04-05 Transmedics, Inc. Systems and methods for ex-vivo organ care
PT1879599E (en) 2005-04-20 2014-01-23 Hutchinson Fred Cancer Res Methods, compositions and articles of manufacture for enhancing survivability of cells, tissues, organs, and organisms
US9078428B2 (en) 2005-06-28 2015-07-14 Transmedics, Inc. Systems, methods, compositions and solutions for perfusing an organ
US20090087328A1 (en) * 2005-11-28 2009-04-02 Faulkner Donald G Pulse generating device
DK3178319T3 (en) 2006-04-19 2020-02-03 Transmedics Inc EX VIVO ORGAN CARE SYSTEMS
US20080145919A1 (en) * 2006-12-18 2008-06-19 Franklin Thomas D Portable organ and tissue preservation apparatus, kit and methods
CN101677526B (en) 2007-03-01 2014-07-09 生命线科学有限公司 Perfusion regulation
US9457179B2 (en) 2007-03-20 2016-10-04 Transmedics, Inc. Systems for monitoring and applying electrical currents in an organ perfusion system
US20080318864A1 (en) * 2007-06-25 2008-12-25 Fred Hutchinson Cancer Research Center Methods and compositions regarding polychalcogenide compositions
US8420380B2 (en) 2008-01-31 2013-04-16 Transmedics, Inc. Systems and methods for ex vivo lung care
US9247729B2 (en) * 2009-05-29 2016-02-02 Institut Georges Lopez Systems and methods for preserving a human organ for transplantation
US9320269B2 (en) 2009-09-25 2016-04-26 John Brassil Organ preservation system
US20120148542A1 (en) 2010-12-10 2012-06-14 Lifeline Scientific, Inc. Machine perfusion with complement inhibitors
ES2913104T3 (en) 2011-04-14 2022-05-31 Transmedics Inc Organ care solution for ex-vivo machine perfusion of donor lungs
US9022978B2 (en) 2011-04-29 2015-05-05 Lifeline Scientific, Inc. Universal sealring cannula
US8828034B2 (en) 2011-04-29 2014-09-09 Lifeline Scientific, Inc. Cannula
US9642625B2 (en) 2011-04-29 2017-05-09 Lifeline Scientific, Inc. Cannula for a donor organ with or without an aortic cuff or patch
GB2510080B (en) * 2011-11-10 2017-09-27 Organox Ltd Organ perfusion systems
EP2775829B1 (en) 2011-11-10 2018-07-11 Organox Limited Organ perfusion systems
GB201119420D0 (en) 2011-11-10 2011-12-21 Organox Ltd Oxygen supply for organ perfusion systems
EP4091446A1 (en) 2012-01-17 2022-11-23 Tevosol, Inc. Apparatus for testing, assessment, and maintenance of harvested hearts for transplanting
US9259562B2 (en) 2012-07-10 2016-02-16 Lifeline Scientific, Inc. Cannula
US9402389B2 (en) * 2012-07-10 2016-08-02 Lifeline Scientific, Inc. Organ transport apparatus with sample compartments
US9357766B2 (en) 2012-07-10 2016-06-07 Lifeline Scientific, Inc. Organ transport apparatus with a document compartment and a tamper evident seal
CN113229273B (en) 2014-03-26 2023-01-31 体沃索股份有限公司 Device for maintaining harvested heart to be transplanted
IL310657A (en) 2014-06-02 2024-04-01 Transmedics Inc Ex vivo organ care system
WO2016090498A1 (en) 2014-12-12 2016-06-16 Freed Darren Apparatus and method for organ perfusion
CN104521864A (en) * 2015-01-07 2015-04-22 青岛海尔股份有限公司 Waterless keep-alive device and refrigerating household appliance provided with waterless keep-alive device
IL310004A (en) 2015-09-09 2024-03-01 Transmedics Inc Aortic cannula for ex vivo organ care system
JP2021017433A (en) 2019-07-24 2021-02-15 株式会社Ｓｃｒｅｅｎホールディングス Organ reception container
US11432543B1 (en) * 2021-10-06 2022-09-06 Bridge To Life Ltd. Organ preservation system with automatic priming and air removal

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US3545225A (en) * 1968-08-16 1970-12-08 Swenko Research & Dev Inc Apparatus for maintaining whole organs in a viable state
US3632473A (en) * 1969-04-21 1972-01-04 Univ California Method and apparatus for preserving human organs extracorporeally
US3753865A (en) * 1971-03-12 1973-08-21 Univ California Method and apparatus for preserving human organs extracorporeally
US3777507A (en) * 1971-11-24 1973-12-11 Waters Instr Inc Renal preservation system
US3896501A (en) * 1973-11-02 1975-07-29 Us Energy Mechanical drive for blood pump
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US3545225A (en) * 1968-08-16 1970-12-08 Swenko Research & Dev Inc Apparatus for maintaining whole organs in a viable state
US3632473A (en) * 1969-04-21 1972-01-04 Univ California Method and apparatus for preserving human organs extracorporeally
US3753865A (en) * 1971-03-12 1973-08-21 Univ California Method and apparatus for preserving human organs extracorporeally
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Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8962303B2 (en) 1998-09-29 2015-02-24 Lifeline Scientific, Inc. Apparatus and method for maintaining and/or restoring viability of organs

Also Published As

Publication number Publication date
CA2108890A1 (en) 1992-10-23
EP0581897A4 (en) 1994-03-17
DE69220938D1 (en) 1997-08-21
EP0581897A1 (en) 1994-02-09
EP0581897B1 (en) 1997-07-16
WO1992019843A2 (en) 1992-11-12
US5157930A (en) 1992-10-27
DE69220938T2 (en) 1998-01-29
AU2153792A (en) 1992-12-21
ES2108123T3 (en) 1997-12-16
AU668869B2 (en) 1996-05-23

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