WO1992021383A1 - Radiolabelled somatostatin derivatives, their preparation and use - Google Patents
Radiolabelled somatostatin derivatives, their preparation and use Download PDFInfo
- Publication number
- WO1992021383A1 WO1992021383A1 PCT/US1992/004559 US9204559W WO9221383A1 WO 1992021383 A1 WO1992021383 A1 WO 1992021383A1 US 9204559 W US9204559 W US 9204559W WO 9221383 A1 WO9221383 A1 WO 9221383A1
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- amino acid
- group
- trp
- phe
- lys
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/655—Somatostatins
- C07K14/6555—Somatostatins at least 1 amino acid in D-form
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
- A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
- A61K51/04—Organic compounds
- A61K51/08—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins
- A61K51/083—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins the peptide being octreotide or a somatostatin-receptor-binding peptide
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
- A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
- A61K51/04—Organic compounds
- A61K51/08—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins
- A61K51/088—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins conjugates with carriers being peptides, polyamino acids or proteins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2121/00—Preparations for use in therapy
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2123/00—Preparations for testing in vivo
Abstract
Description
Claims
Priority Applications (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP5500596A JPH06508357A (en) | 1991-06-03 | 1992-06-02 | Labeled polypeptide, its production method and use |
AU20174/92A AU657770B2 (en) | 1991-06-03 | 1992-06-02 | Radiolabelled somatostatin derivatives, their preparation and use |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
NL9100954 | 1991-06-03 | ||
NL9100954 | 1991-06-03 |
Publications (1)
Publication Number | Publication Date |
---|---|
WO1992021383A1 true WO1992021383A1 (en) | 1992-12-10 |
Family
ID=19859317
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/US1992/004559 WO1992021383A1 (en) | 1991-06-03 | 1992-06-02 | Radiolabelled somatostatin derivatives, their preparation and use |
Country Status (5)
Country | Link |
---|---|
EP (1) | EP0588905A1 (en) |
JP (1) | JPH06508357A (en) |
AU (1) | AU657770B2 (en) |
CA (1) | CA2102633A1 (en) |
WO (1) | WO1992021383A1 (en) |
Cited By (17)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1993015770A1 (en) * | 1992-02-05 | 1993-08-19 | Mallinckrodt Medical, Inc. | Radiolabelled peptide compounds |
US5382654A (en) * | 1992-02-05 | 1995-01-17 | Mallinckrodt Medical, Inc. | Radiolabelled peptide compounds |
US5405597A (en) * | 1991-09-10 | 1995-04-11 | Diatech, Inc. | Technetium-99m labeled somatostatin-derived peptides for imaging |
US5574140A (en) * | 1993-09-03 | 1996-11-12 | Resolution Pharmaceutical Inc. | Hydrazino-type N2 S2 chelators |
WO1997005167A1 (en) * | 1995-07-28 | 1997-02-13 | Romano Deghenghi | Somatostatin-analogous cyclic peptides with inhibitory activity on growth hormone |
US5659041A (en) * | 1993-07-19 | 1997-08-19 | Resolution Pharmaceuticals, Inc. | Hydrazino-type radionuclide chelators having an N3 S configuration |
EP0831936A1 (en) * | 1995-06-07 | 1998-04-01 | Immunomedics, Inc. | Thiolation of peptides for radionuclide-based radiodetection and radiotherapy |
WO1998028336A1 (en) * | 1996-12-20 | 1998-07-02 | Map Medical Technologies Oy | Polysaccharide-peptide derivatives |
US5843401A (en) * | 1992-06-23 | 1998-12-01 | Diatide, Inc. | Radioactively labeled somatostatin-derived peptides for imaging and therapeutic uses |
US5849261A (en) * | 1991-02-08 | 1998-12-15 | Diatide, Inc. | Radiolabeled vasoactive intestinal peptides for diagnosis and therapy |
US5858327A (en) * | 1993-09-03 | 1999-01-12 | Resolutions Pharmaceuticals, Inc. | Hydrazino-type N2 S2 radionuclide chelating compounds |
US5866097A (en) * | 1991-11-27 | 1999-02-02 | Diatide, Inc. | Technetium-99m labeled peptides for imaging |
US5871711A (en) * | 1992-06-23 | 1999-02-16 | Diatide, Inc. | Radioactively-labeled somatostatin-derived peptides for imaging and therapeutic uses |
US5981477A (en) * | 1991-11-27 | 1999-11-09 | Diatide, Inc. | Peptide-metal chelate conjugates |
US6017512A (en) * | 1992-06-23 | 2000-01-25 | Diatide, Inc. | Radiolabeled peptides |
US6051206A (en) * | 1994-06-03 | 2000-04-18 | Diatide, Inc | Radiolabeled somatostatin-derived peptides for imaging and therapeutic uses |
US7060679B2 (en) | 1998-06-19 | 2006-06-13 | Develogen Israel Ltd. | Conformationally constrained backbone cyclized somatostatin analogs |
Citations (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB2021121A (en) * | 1978-05-19 | 1979-11-28 | Meyers Ca Coy D H | Somatostatin analogues having a substituted tryptophyl residue in position eight |
WO1989012068A2 (en) * | 1988-06-03 | 1989-12-14 | Societe D'etudes De Produits Chimiques | Peptides useful for inhibiting blood vessel blockage |
WO1990006949A2 (en) * | 1988-12-05 | 1990-06-28 | Sandoz Ag | Peptide derivatives |
WO1991001754A1 (en) * | 1989-08-09 | 1991-02-21 | Rhodes Buck A | Direct radiolabeling of antibodies and other proteins with technetium or rhenium |
-
1992
- 1992-06-02 CA CA002102633A patent/CA2102633A1/en not_active Abandoned
- 1992-06-02 WO PCT/US1992/004559 patent/WO1992021383A1/en not_active Application Discontinuation
- 1992-06-02 JP JP5500596A patent/JPH06508357A/en active Pending
- 1992-06-02 AU AU20174/92A patent/AU657770B2/en not_active Expired - Fee Related
- 1992-06-02 EP EP92912727A patent/EP0588905A1/en not_active Withdrawn
Patent Citations (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB2021121A (en) * | 1978-05-19 | 1979-11-28 | Meyers Ca Coy D H | Somatostatin analogues having a substituted tryptophyl residue in position eight |
WO1989012068A2 (en) * | 1988-06-03 | 1989-12-14 | Societe D'etudes De Produits Chimiques | Peptides useful for inhibiting blood vessel blockage |
WO1990006949A2 (en) * | 1988-12-05 | 1990-06-28 | Sandoz Ag | Peptide derivatives |
WO1991001754A1 (en) * | 1989-08-09 | 1991-02-21 | Rhodes Buck A | Direct radiolabeling of antibodies and other proteins with technetium or rhenium |
Non-Patent Citations (3)
Title |
---|
CHEMICAL ABSTRACTS, vol. 112, no. 16, 16 April 1990, Columbus, Ohio, US; abstract no. 150685, C.KREMER ET AL: 'Solid-phase reduction of 99mTcO4 with zinc: a method for the preparation of difficult Tc-99m complexes' page 797 ;column 2 ; * |
EUROPEAN JOURNAL OF NUCLEAR MEDICINE vol. 18, no. 8, August 1991, page 558; P.H.COX: 'TECHNETIUM LABELLED SOMATOSTATINE FOR IN VIVO TUMOUR LOCALISATION' * |
THE LANCET vol. 1, no. 8632, 4 February 1989, LONDON pages 242 - 244; E.P.KRENNING ET AL: 'Localisation of endocrine-related tumours with radioiodinated analogue of somatostatin' * |
Cited By (22)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5849261A (en) * | 1991-02-08 | 1998-12-15 | Diatide, Inc. | Radiolabeled vasoactive intestinal peptides for diagnosis and therapy |
US5405597A (en) * | 1991-09-10 | 1995-04-11 | Diatech, Inc. | Technetium-99m labeled somatostatin-derived peptides for imaging |
US5985241A (en) * | 1991-11-27 | 1999-11-16 | Diatide, Inc. | Peptide-metal chelate conjugate complexes |
US5866097A (en) * | 1991-11-27 | 1999-02-02 | Diatide, Inc. | Technetium-99m labeled peptides for imaging |
US5981477A (en) * | 1991-11-27 | 1999-11-09 | Diatide, Inc. | Peptide-metal chelate conjugates |
WO1993015770A1 (en) * | 1992-02-05 | 1993-08-19 | Mallinckrodt Medical, Inc. | Radiolabelled peptide compounds |
US5753205A (en) * | 1992-02-05 | 1998-05-19 | Mallinckrodt Medical, Inc. | Radiolabelled peptide compounds |
US5382654A (en) * | 1992-02-05 | 1995-01-17 | Mallinckrodt Medical, Inc. | Radiolabelled peptide compounds |
US5843401A (en) * | 1992-06-23 | 1998-12-01 | Diatide, Inc. | Radioactively labeled somatostatin-derived peptides for imaging and therapeutic uses |
US5871711A (en) * | 1992-06-23 | 1999-02-16 | Diatide, Inc. | Radioactively-labeled somatostatin-derived peptides for imaging and therapeutic uses |
US6017512A (en) * | 1992-06-23 | 2000-01-25 | Diatide, Inc. | Radiolabeled peptides |
US5659041A (en) * | 1993-07-19 | 1997-08-19 | Resolution Pharmaceuticals, Inc. | Hydrazino-type radionuclide chelators having an N3 S configuration |
US5574140A (en) * | 1993-09-03 | 1996-11-12 | Resolution Pharmaceutical Inc. | Hydrazino-type N2 S2 chelators |
US5858327A (en) * | 1993-09-03 | 1999-01-12 | Resolutions Pharmaceuticals, Inc. | Hydrazino-type N2 S2 radionuclide chelating compounds |
US6051206A (en) * | 1994-06-03 | 2000-04-18 | Diatide, Inc | Radiolabeled somatostatin-derived peptides for imaging and therapeutic uses |
EP0831936A4 (en) * | 1995-06-07 | 2001-05-16 | Immunomedics Inc | Thiolation of peptides for radionuclide-based radiodetection and radiotherapy |
EP0831936A1 (en) * | 1995-06-07 | 1998-04-01 | Immunomedics, Inc. | Thiolation of peptides for radionuclide-based radiodetection and radiotherapy |
WO1997005167A1 (en) * | 1995-07-28 | 1997-02-13 | Romano Deghenghi | Somatostatin-analogous cyclic peptides with inhibitory activity on growth hormone |
KR100321448B1 (en) * | 1995-07-28 | 2002-07-31 | 데겐기로마노 | Somatostatin-Alike Cytotype Peptides with Growth Hormone Inhibitory Activity |
WO1998028336A1 (en) * | 1996-12-20 | 1998-07-02 | Map Medical Technologies Oy | Polysaccharide-peptide derivatives |
US6455025B1 (en) | 1996-12-20 | 2002-09-24 | Map Medical Technologies Oy | Polysaccharide-peptide derivatives |
US7060679B2 (en) | 1998-06-19 | 2006-06-13 | Develogen Israel Ltd. | Conformationally constrained backbone cyclized somatostatin analogs |
Also Published As
Publication number | Publication date |
---|---|
JPH06508357A (en) | 1994-09-22 |
CA2102633A1 (en) | 1992-12-04 |
AU2017492A (en) | 1993-01-08 |
EP0588905A1 (en) | 1994-03-30 |
AU657770B2 (en) | 1995-03-23 |
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