WO1993022657A3 - Luminometer with reduced sample crosstalk - Google Patents

Luminometer with reduced sample crosstalk Download PDF

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Publication number
WO1993022657A3
WO1993022657A3 PCT/US1993/004115 US9304115W WO9322657A3 WO 1993022657 A3 WO1993022657 A3 WO 1993022657A3 US 9304115 W US9304115 W US 9304115W WO 9322657 A3 WO9322657 A3 WO 9322657A3
Authority
WO
WIPO (PCT)
Prior art keywords
tray
photodetector assembly
luminometer
photodetector
head
Prior art date
Application number
PCT/US1993/004115
Other languages
French (fr)
Other versions
WO1993022657A2 (en
Inventor
Rick T Smethers
Brian D Warner
Victor P Burolla
Original Assignee
Chiron Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Chiron Corp filed Critical Chiron Corp
Priority to EP93910971A priority Critical patent/EP0725929B1/en
Priority to DE69331281T priority patent/DE69331281T2/en
Priority to AT93910971T priority patent/ATE210288T1/en
Priority to CA002135170A priority patent/CA2135170C/en
Publication of WO1993022657A2 publication Critical patent/WO1993022657A2/en
Publication of WO1993022657A3 publication Critical patent/WO1993022657A3/en

Links

Classifications

    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/75Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated
    • G01N21/76Chemiluminescence; Bioluminescence
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
    • G01N35/02Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor using a plurality of sample containers moved by a conveyor system past one or more treatment or analysis stations
    • G01N35/028Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor using a plurality of sample containers moved by a conveyor system past one or more treatment or analysis stations having reaction cells in the form of microtitration plates
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
    • G01N2035/00346Heating or cooling arrangements
    • G01N2035/00356Holding samples at elevated temperature (incubation)
    • G01N2035/00376Conductive heating, e.g. heated plates
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
    • G01N35/02Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor using a plurality of sample containers moved by a conveyor system past one or more treatment or analysis stations
    • G01N35/04Details of the conveyor system
    • G01N2035/0474Details of actuating means for conveyors or pipettes
    • G01N2035/0482Transmission
    • G01N2035/0487Helix or lead screw
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10STECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S435/00Chemistry: molecular biology and microbiology
    • Y10S435/808Optical sensing apparatus

Abstract

A luminometer is described comprising a tray for receiving an array of sample wells, a photodetector assembly, and means for relatively moving the tray and photodetector assembly in one direction to align the sample wells received by the tray in a predetermined sequence with the photodetector assembly. The photodetector assembly of the luminometer includes a stage, a photodetection head having a detection aperture permitting passage of light therethrough, a means for mounting the photodetection head to the stage that permits movement of the head in a direction substantially normal to the direction of relative tray and photodetector assembly movement, and a means for biasing the photodetection head toward a selected sample well so that the detection aperture is substantially isolated from light emitted from adjacent wells. Internal and external photodetector calibration systems and a sample heater are also contemplated.
PCT/US1993/004115 1992-05-05 1993-05-03 Luminometer with reduced sample crosstalk WO1993022657A2 (en)

Priority Applications (4)

Application Number Priority Date Filing Date Title
EP93910971A EP0725929B1 (en) 1992-05-05 1993-05-03 Luminometer with reduced sample crosstalk
DE69331281T DE69331281T2 (en) 1992-05-05 1993-05-03 LUMINOMETER WITH REDUCED INTERFERENCE FROM NEIGHBORED SAMPLES
AT93910971T ATE210288T1 (en) 1992-05-05 1993-05-03 LUMINOMETER WITH REDUCED INTERFERENCE FROM ADJACENT SAMPLES
CA002135170A CA2135170C (en) 1992-05-05 1993-05-03 Luminometer with reduced sample crosstalk

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US878,829 1992-05-05
US07/878,829 US5401465A (en) 1992-05-05 1992-05-05 Luminometer with reduced sample crosstalk

Publications (2)

Publication Number Publication Date
WO1993022657A2 WO1993022657A2 (en) 1993-11-11
WO1993022657A3 true WO1993022657A3 (en) 1994-01-20

Family

ID=25372935

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US1993/004115 WO1993022657A2 (en) 1992-05-05 1993-05-03 Luminometer with reduced sample crosstalk

Country Status (8)

Country Link
US (3) US5401465A (en)
EP (1) EP0725929B1 (en)
JP (3) JP2802835B2 (en)
AT (1) ATE210288T1 (en)
CA (1) CA2135170C (en)
DE (1) DE69331281T2 (en)
ES (1) ES2166762T3 (en)
WO (1) WO1993022657A2 (en)

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Also Published As

Publication number Publication date
US5716583A (en) 1998-02-10
EP0725929A1 (en) 1996-08-14
US5643535A (en) 1997-07-01
ES2166762T3 (en) 2002-05-01
JPH07506433A (en) 1995-07-13
DE69331281T2 (en) 2002-05-23
JP2001194293A (en) 2001-07-19
JPH10293098A (en) 1998-11-04
DE69331281D1 (en) 2002-01-17
US5401465A (en) 1995-03-28
JP3181257B2 (en) 2001-07-03
EP0725929B1 (en) 2001-12-05
JP2802835B2 (en) 1998-09-24
CA2135170A1 (en) 1993-11-11
CA2135170C (en) 2000-01-25
JP3513485B2 (en) 2004-03-31
ATE210288T1 (en) 2001-12-15
WO1993022657A2 (en) 1993-11-11

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