WO1994000489A3 - Radioactively-labeled somatostantin-derived peptides for imaging and therapeutic uses - Google Patents

Radioactively-labeled somatostantin-derived peptides for imaging and therapeutic uses Download PDF

Info

Publication number
WO1994000489A3
WO1994000489A3 PCT/US1993/006029 US9306029W WO9400489A3 WO 1994000489 A3 WO1994000489 A3 WO 1994000489A3 US 9306029 W US9306029 W US 9306029W WO 9400489 A3 WO9400489 A3 WO 9400489A3
Authority
WO
WIPO (PCT)
Prior art keywords
labeled
peptides
somatostantin
radioactively
imaging
Prior art date
Application number
PCT/US1993/006029
Other languages
French (fr)
Other versions
WO1994000489A2 (en
Inventor
Richard T Dean
John Lister-James
Original Assignee
Diatech Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Diatech Inc filed Critical Diatech Inc
Priority to DK93918129T priority Critical patent/DK0649434T3/en
Priority to JP6502568A priority patent/JPH08503924A/en
Priority to AT93918129T priority patent/ATE203754T1/en
Priority to DE69330521T priority patent/DE69330521T2/en
Priority to AU47688/93A priority patent/AU690071B2/en
Priority to CA002138647A priority patent/CA2138647C/en
Priority to US08/347,397 priority patent/US5871711A/en
Priority to EP93918129A priority patent/EP0649434B1/en
Publication of WO1994000489A2 publication Critical patent/WO1994000489A2/en
Publication of WO1994000489A3 publication Critical patent/WO1994000489A3/en
Priority to ES94920076T priority patent/ES2158897T3/en
Priority to EP94920076A priority patent/EP0720621B1/en
Priority to SG1996004666A priority patent/SG48977A1/en
Priority to DE69434832T priority patent/DE69434832D1/en
Priority to AT00122241T priority patent/ATE337338T1/en
Priority to EP00122242A priority patent/EP1099707A3/en
Priority to DE69426673T priority patent/DE69426673T2/en
Priority to AU70990/94A priority patent/AU701083B2/en
Priority to DK94920076T priority patent/DK0720621T3/en
Priority to EP00122241A priority patent/EP1092726B1/en
Priority to PCT/US1994/006274 priority patent/WO1995000553A1/en
Priority to AT94920076T priority patent/ATE199089T1/en
Priority to ZA944498A priority patent/ZA944498B/en
Priority to AU77481/98A priority patent/AU7748198A/en
Priority to AU18288/01A priority patent/AU776961B2/en
Priority to GR20010400678T priority patent/GR3035830T3/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/655—Somatostatins
    • C07K14/6555—Somatostatins at least 1 amino acid in D-form
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/08—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins
    • A61K51/083—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins the peptide being octreotide or a somatostatin-receptor-binding peptide
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/08—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins
    • A61K51/088—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins conjugates with carriers being peptides, polyamino acids or proteins
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
    • C07K14/36—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Actinomyces; from Streptomyces (G)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2121/00—Preparations for use in therapy
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2123/00—Preparations for testing in vivo
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S930/00—Peptide or protein sequence
    • Y10S930/01—Peptide or protein sequence
    • Y10S930/16—Somatostatin; related peptides

Abstract

This invention relates to therapeutic reagents and peptides, radiodiagnostic reagents and peptides, and methods for producing labeled radiodiagnostic agents. Specifically, the invention relates to peptide derivatives and analogs of somatostatin, and embodiments of such peptides labeled with technetium-99m (Tc-99m), as well as methods and kits for making, radiolabeling and using such peptides to image sites in a mammalian body. The invention also relatees to peptide derivatives and analogues of somatostantin labeled with rhenium-186 (<186>Re) and rhenium-188 (<188>Re), and methods and kits for making, radiolabeling and using such peptides therapeutically in a mammalian body.
PCT/US1993/006029 1992-01-14 1993-06-23 Radioactively-labeled somatostantin-derived peptides for imaging and therapeutic uses WO1994000489A2 (en)

Priority Applications (24)

Application Number Priority Date Filing Date Title
DK93918129T DK0649434T3 (en) 1992-06-23 1993-06-23 Radiolabeled somatostatin-derived peptides for imaging and therapeutic applications
JP6502568A JPH08503924A (en) 1992-06-23 1993-06-23 Radiolabeled somatostatin-derived peptides for imaging and therapeutic applications
AT93918129T ATE203754T1 (en) 1992-06-23 1993-06-23 RADIOACTIVE-LABELED PEPTIDE DERIVATIVES OF SOMATOSTATIN FOR IMAGE-FORMING AND THERAPEUTIC USE
DE69330521T DE69330521T2 (en) 1992-06-23 1993-06-23 RADIOACTIVE-MARKED PEPTIDE DERIVATIVES OF SOMATOSTATIN FOR IMAGE-SHAPING AND THERAPEUTIC USE
AU47688/93A AU690071B2 (en) 1992-06-23 1993-06-23 Radioactively-labeled somatostantin-derived peptides for imaging and therapeutic uses
CA002138647A CA2138647C (en) 1992-06-23 1993-06-23 Radioactively-labeled somatostatin-derived peptides for imaging and therapeutic uses
US08/347,397 US5871711A (en) 1992-06-23 1993-06-23 Radioactively-labeled somatostatin-derived peptides for imaging and therapeutic uses
EP93918129A EP0649434B1 (en) 1992-06-23 1993-06-23 Radioactively-labeled somatostatin-derived peptides for imaging and therapeutic uses
PCT/US1994/006274 WO1995000553A1 (en) 1993-06-23 1994-06-03 Radiolabeled somatostatin-derived peptides for imaging and therapeutic uses
AT94920076T ATE199089T1 (en) 1993-06-23 1994-06-03 RADIOM LABELED SOMATOSTATIN DERIVATIVES FOR IMAGING AND THERAPEUTIC USE
AU70990/94A AU701083B2 (en) 1993-06-23 1994-06-03 Radiolabeled somatostatin-derived peptides for imaging and therapeutic uses
ES94920076T ES2158897T3 (en) 1993-06-23 1994-06-03 RADIOMARCED PEPTIDES DERIVED FROM SOMATOSTATINE AND USED IN PROCEDURES FOR IMAGE AND THERAPEUTIC FORMATION.
SG1996004666A SG48977A1 (en) 1993-06-23 1994-06-03 Radiolabeled peptides
DE69434832T DE69434832D1 (en) 1993-06-23 1994-06-03 Radiolabeled peptide derivatives of somatostatin for imaging and therapeutic use
AT00122241T ATE337338T1 (en) 1993-06-23 1994-06-03 RADIOACTIVE-LABELED PEPTIDE DERIVATIVES OF SOMATOSTATIN FOR IMAGE-FORMING AND THERAPEUTIC USE
EP00122242A EP1099707A3 (en) 1993-06-23 1994-06-03 Radiolabeled somatostatin-derived peptides for imaging and therapeutic uses
DE69426673T DE69426673T2 (en) 1993-06-23 1994-06-03 RADIO-MARKED SOMATOSTATIN DERIVATIVES FOR IMAGING AND THERAPEUTIC USE
EP94920076A EP0720621B1 (en) 1993-06-23 1994-06-03 Radiolabeled somatostatin-derived peptides for imaging and therapeutic uses
DK94920076T DK0720621T3 (en) 1992-01-14 1994-06-03 Radiolabeled somatostation-derived peptides for imaging and therapeutic applications
EP00122241A EP1092726B1 (en) 1993-06-23 1994-06-03 Radioactively-labeled somatostatin derived peptides for imaging and therapeutics uses
ZA944498A ZA944498B (en) 1993-06-23 1994-06-23 Radiolabeled peptides
AU77481/98A AU7748198A (en) 1992-06-23 1998-07-23 Radioactively-labeled somatostantin-derived peptides for imaging and therapeutic uses
AU18288/01A AU776961B2 (en) 1992-06-23 2001-02-05 Radioactively-labeled somatostantin-derived peptides for imaging and therapeutic uses
GR20010400678T GR3035830T3 (en) 1993-06-23 2001-05-07 Radiolabeled somatostatin-derived peptides for imaging and therapeutic uses

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US07/902,935 US5716596A (en) 1992-06-23 1992-06-23 Radioactively labeled somatostatin-derived peptides for imaging and therapeutic uses
US902,935 1992-06-23

Publications (2)

Publication Number Publication Date
WO1994000489A2 WO1994000489A2 (en) 1994-01-06
WO1994000489A3 true WO1994000489A3 (en) 1994-03-31

Family

ID=25416650

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US1993/006029 WO1994000489A2 (en) 1992-01-14 1993-06-23 Radioactively-labeled somatostantin-derived peptides for imaging and therapeutic uses

Country Status (10)

Country Link
US (5) US5716596A (en)
EP (2) EP1094074A3 (en)
JP (1) JPH08503924A (en)
AT (1) ATE203754T1 (en)
AU (1) AU690071B2 (en)
CA (1) CA2138647C (en)
DE (1) DE69330521T2 (en)
DK (1) DK0649434T3 (en)
ES (1) ES2164667T3 (en)
WO (1) WO1994000489A2 (en)

Families Citing this family (58)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5443816A (en) * 1990-08-08 1995-08-22 Rhomed Incorporated Peptide-metal ion pharmaceutical preparation and method
US5736122A (en) * 1991-02-08 1998-04-07 Diatide, Inc. Technetium-99m labeled peptides for thrombus imaging
US5849261A (en) * 1991-02-08 1998-12-15 Diatide, Inc. Radiolabeled vasoactive intestinal peptides for diagnosis and therapy
US5965107A (en) * 1992-03-13 1999-10-12 Diatide, Inc. Technetium-99m labeled peptides for imaging
US5443815A (en) * 1991-11-27 1995-08-22 Diatech, Inc. Technetium-99m labeled peptides for imaging
US5997844A (en) * 1991-02-08 1999-12-07 Diatide, Inc. Technetium-99m labeled peptides for imaging
US7238340B1 (en) * 1991-11-27 2007-07-03 Cis Bio International Monoamine, diamide, thiol-containing metal chelating agents
EP0570493B1 (en) * 1991-02-08 2000-01-05 Diatide, Inc. TECHNETIUM-99m LABELED POLYPEPTIDES FOR IMAGING
US5645815A (en) 1991-02-08 1997-07-08 Diatide, Inc. Radiolabled compounds for thrombus imaging
US6183722B1 (en) * 1991-11-27 2001-02-06 Diatide, Inc. Somatostatin analogs
US5783170A (en) * 1991-11-27 1998-07-21 Diatide, Inc. Peptide-metal chelate conjugates
US5968476A (en) * 1992-05-21 1999-10-19 Diatide, Inc. Technetium-99m labeled peptides for thrombus imaging
US6017512A (en) * 1992-06-23 2000-01-25 Diatide, Inc. Radiolabeled peptides
US5620675A (en) 1992-06-23 1997-04-15 Diatech, Inc. Radioactive peptides
US5932189A (en) * 1994-07-29 1999-08-03 Diatech, Inc. Cyclic peptide somatostatin analogs
SG93839A1 (en) * 1993-07-15 2003-01-21 Diatide Inc Radiolabeled peptides
EP0788377B1 (en) * 1993-07-28 2000-09-27 Diatide, Inc. Radiolabelled glucans
DK96493D0 (en) * 1993-08-26 1993-08-26 Mouritsen Og Elsner Aps PROCEDURE FOR INDUCING ANTIBODY RESPONSE TO SELF-PROTEINS AND AUTOVACCINE PROCESSED BY THE PROCEDURE
EP0772459B1 (en) * 1994-05-02 2003-03-19 Diatide, Inc. TECHNETIUM-99m LABELED IMAGING AGENTS
US6051206A (en) * 1994-06-03 2000-04-18 Diatide, Inc Radiolabeled somatostatin-derived peptides for imaging and therapeutic uses
US5556939A (en) * 1994-10-13 1996-09-17 Merck Frosst Canada, Inc. TC or RE radionuclide labelled chelate, hexapeptide complexes useful for diagnostic or therapeutic applications
US5891418A (en) * 1995-06-07 1999-04-06 Rhomed Incorporated Peptide-metal ion pharmaceutical constructs and applications
US5753206A (en) 1995-06-07 1998-05-19 Immunomedics, Inc. Radiometal-binding analogues of luteinizing hormone releasing hormone
MY147327A (en) * 1995-06-29 2012-11-30 Novartis Ag Somatostatin peptides
DE19536783A1 (en) * 1995-09-21 1997-03-27 Diagnostikforschung Inst Bifunctional nicotinamide chelating agents of the type N¶2¶S¶2¶ for radioactive isotopes
US6331285B1 (en) 1996-06-05 2001-12-18 Palatin Technologies, Inc. Structurally determined cyclic metallo-constructs and applications
WO1998008100A1 (en) * 1996-08-23 1998-02-26 Patel, Cell & Receptor Technologies Inc. Agonist-dependent internalization of human somatostatin receptors types 1-5
WO1999055385A2 (en) * 1998-04-28 1999-11-04 Wolfgang Bergter Radioimmunopharmaca for treating hepatitis c
US6652836B2 (en) 1998-10-15 2003-11-25 Fluoroprobe, Inc. Method for viewing tumor tissue located within a body cavity
US6870914B1 (en) * 1999-01-29 2005-03-22 Sbc Properties, L.P. Distributed text-to-speech synthesis between a telephone network and a telephone subscriber unit
US20020102208A1 (en) 1999-03-01 2002-08-01 Paul Chinn Radiolabeling kit and binding assay
MY133346A (en) * 1999-03-01 2007-11-30 Biogen Inc Kit for radiolabeling ligands with yttrium-90
US6254852B1 (en) 1999-07-16 2001-07-03 Dupont Pharmaceuticals Company Porous inorganic targeted ultrasound contrast agents
US6358491B1 (en) * 1999-08-27 2002-03-19 Berlex Laboratories, Inc. Somatostatin analogs
US6685914B1 (en) 1999-09-13 2004-02-03 Bristol-Myers Squibb Pharma Company Macrocyclic chelants for metallopharmaceuticals
US7067111B1 (en) * 1999-10-25 2006-06-27 Board Of Regents, University Of Texas System Ethylenedicysteine (EC)-drug conjugates, compositions and methods for tissue specific disease imaging
GB0018891D0 (en) 2000-08-01 2000-09-20 Novartis Ag Organic compounds
CA2410906C (en) * 2000-06-02 2012-10-02 Board Of Regents, The University Of Texas System Ethylenedicysteine (ec)-drug conjugates
US7385025B2 (en) 2000-12-19 2008-06-10 Palatin Technologies, Inc. Metallopeptide compounds
FR2845389B1 (en) * 2002-10-04 2007-01-12 Solvay PROCESS FOR THE SYNTHESIS OF PEPTIDES COMPRISING AT LEAST ONE GLYCIN MOLECULE
WO2004081031A2 (en) * 2003-03-10 2004-09-23 Biogen Idec Inc. Thiol-mediated drug attachment to targeting peptides
AR044852A1 (en) 2003-06-24 2005-10-05 Novartis Ag A PHARMACEUTICAL COMPOSITION FOR PARENTERAL ADMINISTRATION THAT INCLUDES A SOMATOSTATINE ANALOG
US7968080B2 (en) * 2003-08-20 2011-06-28 The Regents Of The University Of California Somatostatin analogs with inhibitory activity to growth hormone release
US9050378B2 (en) * 2003-12-10 2015-06-09 Board Of Regents, The University Of Texas System N2S2 chelate-targeting ligand conjugates
WO2007042504A2 (en) 2005-10-07 2007-04-19 Guerbet Compounds comprising a biological target recognizing part, coupled to a signal part capable of complexing gallium
US8986650B2 (en) 2005-10-07 2015-03-24 Guerbet Complex folate-NOTA-Ga68
US8758723B2 (en) 2006-04-19 2014-06-24 The Board Of Regents Of The University Of Texas System Compositions and methods for cellular imaging and therapy
US10925977B2 (en) 2006-10-05 2021-02-23 Ceil>Point, LLC Efficient synthesis of chelators for nuclear imaging and radiotherapy: compositions and applications
WO2008050255A2 (en) * 2006-10-25 2008-05-02 Koninklijke Philips Electronics N. V. Contrast agents for detecting prostate cancer
CA2699912A1 (en) * 2007-09-19 2009-03-26 Oncofluor, Inc. Method for imaging and treating organs and tissues
FR2942227B1 (en) 2009-02-13 2011-04-15 Guerbet Sa USE OF BUFFERS FOR RADIONUCLEID COMPLEXATION
FR2968999B1 (en) 2010-12-20 2013-01-04 Guerbet Sa CHELATE NANOEMULSION FOR MRI
FR2980364B1 (en) 2011-09-26 2018-08-31 Guerbet NANOEMULSIONS AND THEIR USE AS CONTRAST AGENTS
US20140147381A1 (en) * 2012-11-29 2014-05-29 Gregory David Espenan 89zr compounds, to include somatostatin, apparatus and products comprising such compounds, methods of making same, and methods of using same for radio imaging and/or treatment
FR3001154B1 (en) 2013-01-23 2015-06-26 Guerbet Sa MAGNETO-EMULSION VECTORIZED
CA2903994C (en) 2013-03-15 2017-08-22 Philip S. Low Synthesis and composition of amino acid linking groups conjugated to compounds used for the targeted imaging of tumors
AU2016287304A1 (en) * 2015-06-30 2018-01-04 Tarveda Therapeutics, Inc. Targeted conjugates and particles and formulations thereof
WO2020007822A1 (en) 2018-07-02 2020-01-09 Conservatoire National Des Arts Et Metiers (Cnam) Bismuth metallic (0) nanoparticles, process of manufacturing and uses thereof

Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2320109A1 (en) * 1975-08-08 1977-03-04 Merck & Co Inc SOMATOSTATIN ANALOGUES
FR2336943A1 (en) * 1976-01-02 1977-07-29 Ayerst Mckenna & Harrison SOMATOSTATIN DERIVATIVES AND THEIR PREPARATION
WO1989010759A1 (en) * 1988-04-29 1989-11-16 Mallinckrodt, Inc. Diaminedithiol chelating agents for radiopharmaceuticals
WO1990006949A2 (en) * 1988-12-05 1990-06-28 Sandoz Ag Peptide derivatives
EP0453082A1 (en) * 1990-03-09 1991-10-23 Hybritech Incorporated Trifunctional antibody-like compounds as a combined diagnostic and therapeutic agent
US5095111A (en) * 1989-03-17 1992-03-10 The John Hopkins University Thiolactone bifunctional chelating agents for diagnostic and therapeutic products
WO1993003056A1 (en) * 1991-08-09 1993-02-18 Winfried Kolbeck Lanthionine bridged peptides

Family Cites Families (40)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CH379524A (en) 1959-05-05 1964-07-15 Inventa Ag Process for the production of methionine
US4244947A (en) * 1979-08-13 1981-01-13 Ayerst Mckenna And Harrison Inc. Carba decapeptide derivatives of [TYR6 ]-somatostatin
US4235886A (en) * 1979-10-31 1980-11-25 Merck & Co., Inc. Cyclic hexapeptide somatostatin analogs
US4444690A (en) * 1982-02-25 1984-04-24 University Patents, Inc. Technetium chelates
US4472509A (en) * 1982-06-07 1984-09-18 Gansow Otto A Metal chelate conjugated monoclonal antibodies
EP0113029B1 (en) * 1982-12-06 1989-04-19 Merck & Co. Inc. Dicyclic hexapeptides, processes for their preparation and pharmaceutical compositions containing them
US4485101A (en) * 1983-10-11 1984-11-27 Administrators Of The Tulane Educational Fund Peptides
US4684620A (en) * 1984-09-04 1987-08-04 Gibson-Stephens Neuropharmaceuticals, Inc. Cyclic polypeptides having mu-receptor specificity
HUT42101A (en) * 1985-01-07 1987-06-29 Sandoz Ag Process for preparing stomatostatine derivatives and pharmaceutical compositions containing such compounds
US4650787A (en) * 1985-04-25 1987-03-17 Schally Andrew Victor Biologically active octapeptides
US4611054A (en) * 1985-04-29 1986-09-09 Merck & Co., Inc. Cyclic hexapeptide somatostatin analogs
US4612366A (en) * 1985-06-17 1986-09-16 Merck & Co., Inc. Cyclic hexapeptide somatostatin analogs
US4904642A (en) * 1985-09-12 1990-02-27 The Administrators Of The Tulane Educational Fund Therapeutic somatostatin analogs
US4877868A (en) * 1986-03-12 1989-10-31 Neorx Corporation Radionuclide antibody coupling
US4853371A (en) * 1986-06-17 1989-08-01 The Administrators Of The Tulane Educational Fund Therapeutic somatostatin analogs
US4871717A (en) * 1987-01-07 1989-10-03 Administrators Of The Tulane Educational Fund Peptides
ATE107862T1 (en) * 1987-04-02 1994-07-15 Centocor Inc METHOD FOR LABELING ANTIBODIES WITH A METAL ION.
US5073541A (en) * 1987-11-18 1991-12-17 Administrators Of The Tulane Educational Fund Treatment of small cell lung cancer with somatostatin analogs
US5395946A (en) * 1988-02-09 1995-03-07 Goedemans; Wilhelmus T. Bifunctional chelating agents
US4988496A (en) * 1988-05-31 1991-01-29 Neorx Corporation Metal radionuclide chelating compounds for improved chelation kinetics
GB9111199D0 (en) * 1991-05-23 1991-07-17 Sandoz Ltd Improvements in or relating to organic compounds
US5066716A (en) * 1988-12-13 1991-11-19 The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services Synthesis of chloroacetyl and bromoacetyl modified peptides for the preparation of synthetic peptide polymers, conjugated peptides, and cyclic peptides
US5196510A (en) * 1988-12-29 1993-03-23 Cytogen Corporation Molecular recognition units
CA2012115C (en) * 1989-03-15 2001-07-03 Biomeasure, Inc. Iodinated somatostatins
KR0173119B1 (en) * 1989-04-26 1999-02-01 닐 에이. 밴스로우 Linear somatostatin analog
AU638043B2 (en) * 1989-07-20 1993-06-17 Novartis Ag Labeled polypeptide derivatives
US5443816A (en) * 1990-08-08 1995-08-22 Rhomed Incorporated Peptide-metal ion pharmaceutical preparation and method
US5460785A (en) * 1989-08-09 1995-10-24 Rhomed Incorporated Direct labeling of antibodies and other protein with metal ions
DK0457888T3 (en) * 1989-12-08 1996-08-12 Univ Tulane Octapeptide analogues of somatostatin with threonine at the 6-position
EP0450480B1 (en) * 1990-04-06 1995-06-21 The Administrators of The Tulane Educational Fund Somatostatin Analogues
US5382654A (en) * 1992-02-05 1995-01-17 Mallinckrodt Medical, Inc. Radiolabelled peptide compounds
US5443815A (en) * 1991-11-27 1995-08-22 Diatech, Inc. Technetium-99m labeled peptides for imaging
JPH05506254A (en) * 1991-02-08 1993-09-16 バイオメジャー，インコーポレイテッド Treatment methods for benign and malignant proliferative skin diseases
US5409894A (en) * 1991-03-14 1995-04-25 Sandoz Ltd. Method of preventing balloon catheterization blood vessel damage
CA2102633A1 (en) * 1991-06-03 1992-12-04 Peter H. Cox Radiolabelled somatostatin derivatives, their preparation and use
US5225180A (en) * 1991-09-10 1993-07-06 Diatech, Inc. Technetium-99m labeled somatostatin-derived peptides for imaging
US5508020A (en) * 1992-06-05 1996-04-16 Diatech, Inc. Technetium-99M labeled peptides for imaging
US5620675A (en) * 1992-06-23 1997-04-15 Diatech, Inc. Radioactive peptides
SG93839A1 (en) * 1993-07-15 2003-01-21 Diatide Inc Radiolabeled peptides
US5443806A (en) * 1994-03-22 1995-08-22 A. Ahlstrom Corporation Treating exhaust gas from a pressurized fluidized bed reaction system

Patent Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2320109A1 (en) * 1975-08-08 1977-03-04 Merck & Co Inc SOMATOSTATIN ANALOGUES
FR2336943A1 (en) * 1976-01-02 1977-07-29 Ayerst Mckenna & Harrison SOMATOSTATIN DERIVATIVES AND THEIR PREPARATION
WO1989010759A1 (en) * 1988-04-29 1989-11-16 Mallinckrodt, Inc. Diaminedithiol chelating agents for radiopharmaceuticals
WO1990006949A2 (en) * 1988-12-05 1990-06-28 Sandoz Ag Peptide derivatives
US5095111A (en) * 1989-03-17 1992-03-10 The John Hopkins University Thiolactone bifunctional chelating agents for diagnostic and therapeutic products
EP0453082A1 (en) * 1990-03-09 1991-10-23 Hybritech Incorporated Trifunctional antibody-like compounds as a combined diagnostic and therapeutic agent
WO1993003056A1 (en) * 1991-08-09 1993-02-18 Winfried Kolbeck Lanthionine bridged peptides

Non-Patent Citations (5)

* Cited by examiner, † Cited by third party
Title
CHEMICAL ABSTRACTS, vol. 115, no. 15, 14 October 1991, Columbus, Ohio, US; abstract no. 159733, B.LI ET AL: "A NEW BIFUNCTIONAL CHELATING AGENT ALPHA,EPSILON-N,N'-BIS(L-CYTEINYL)-L-LYSINE FOR RADIOLABLEING OF MONOCLONAL ANTIBODIES WITH TC-99M" page 1001; column 2; *
CHIN. CHEM. LETT., vol. 2, no. 4, 1991, pages 285 - 288 *
J.E.RIVIER ET AL: "PEPTIDES;CHEMISTRY,STRUCTURE AND BIOLOGY", 1991, ESCOM, LEIDEN *
N.BRYSON: "PROTECTING GROUPS IN THE PREPARATION OF THIOLATE COMPLEXES OF TECHNETIUM", INORGANIC CHEMISTRY, vol. 29, no. 16, 8 August 1990 (1990-08-08), pages 2948 - 2951 *
Y.ARANO ET AL: "A NOVEL BIFUNCTIONAL METABOLISABLE LINKER FOR THE CONJUGATION OF ANTIBODIES WITH RADIONUCLEOTIDES", BIOCONJ.CHEM., vol. 2, no. 2, 1991, WASHINGTON, pages 71 - 76 *

Also Published As

Publication number Publication date
US5833942A (en) 1998-11-10
EP1094074A3 (en) 2002-01-09
WO1994000489A2 (en) 1994-01-06
US5843401A (en) 1998-12-01
EP0649434A1 (en) 1995-04-26
ES2164667T3 (en) 2002-03-01
US5820845A (en) 1998-10-13
ATE203754T1 (en) 2001-08-15
US5814298A (en) 1998-09-29
CA2138647C (en) 2002-11-12
EP1094074A2 (en) 2001-04-25
CA2138647A1 (en) 1994-01-06
JPH08503924A (en) 1996-04-30
DE69330521D1 (en) 2001-09-06
AU690071B2 (en) 1998-04-23
DE69330521T2 (en) 2002-05-16
AU4768893A (en) 1994-01-24
EP0649434B1 (en) 2001-08-01
US5716596A (en) 1998-02-10
DK0649434T3 (en) 2001-11-12

Similar Documents

Publication Publication Date Title
WO1994000489A3 (en) Radioactively-labeled somatostantin-derived peptides for imaging and therapeutic uses
EP1099707A3 (en) Radiolabeled somatostatin-derived peptides for imaging and therapeutic uses
WO1993010747A3 (en) Technetium-99m labeled peptides for imaging
CA2167678A1 (en) Radioactive peptides
CA2216851A1 (en) Radiolabeled peptides for diagnosis and therapy
CA2111863A1 (en) Technetium-99m labeled peptides for imaging
CA2131816A1 (en) Technetium-99m labeled peptides for imaging inflammation
CA2137009A1 (en) Technetium-99m labeled peptides for imaging
ZA954547B (en) Technetium-99m labeled peptides for imaging
CA2195395A1 (en) Cyclic hexapeptide somatostatin analogues
CA2347670A1 (en) Radiolabeled somatostatin-derived peptides for imaging

Legal Events

Date Code Title Description
AK Designated states

Kind code of ref document: A2

Designated state(s): AU CA JP KR US

AL Designated countries for regional patents

Kind code of ref document: A2

Designated state(s): AT BE CH DE DK ES FR GB GR IE IT LU MC NL PT SE

AK Designated states

Kind code of ref document: A3

Designated state(s): AU CA JP KR US

AL Designated countries for regional patents

Kind code of ref document: A3

Designated state(s): AT BE CH DE DK ES FR GB GR IE IT LU MC NL PT SE

DFPE Request for preliminary examination filed prior to expiration of 19th month from priority date (pct application filed before 20040101)
121 Ep: the epo has been informed by wipo that ep was designated in this application
WWE Wipo information: entry into national phase

Ref document number: 2138647

Country of ref document: CA

WWE Wipo information: entry into national phase

Ref document number: 08347397

Country of ref document: US

WWE Wipo information: entry into national phase

Ref document number: 1993918129

Country of ref document: EP

WWP Wipo information: published in national office

Ref document number: 1993918129

Country of ref document: EP

WWG Wipo information: grant in national office

Ref document number: 1993918129

Country of ref document: EP