WO1994003170A1 - Terfenadine metabolites and their optically pure isomers for treating allergic disorders - Google Patents
Terfenadine metabolites and their optically pure isomers for treating allergic disorders Download PDFInfo
- Publication number
- WO1994003170A1 WO1994003170A1 PCT/US1993/007260 US9307260W WO9403170A1 WO 1994003170 A1 WO1994003170 A1 WO 1994003170A1 US 9307260 W US9307260 W US 9307260W WO 9403170 A1 WO9403170 A1 WO 9403170A1
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- compound
- pharmaceutical composition
- formula
- treatment
- terfenadine
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/16—Otologicals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Abstract
Description
Claims
Priority Applications (20)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE69316660T DE69316660T3 (en) | 1992-08-03 | 1993-08-03 | Terfanadine metabolites and their optically pure isomers for the treatment of allergic diseases |
AU47986/93A AU675240B2 (en) | 1992-08-03 | 1993-08-03 | Terfenadine metabolites and their optically pure isomers for treating allergic disorders |
RO95-00160A RO116043B1 (en) | 1992-08-03 | 1993-08-03 | Pharmaceutical composition |
JP6505499A JP3041954B2 (en) | 1992-08-03 | 1993-08-03 | Terfenadine metabolites and their optically pure isomers for the treatment of allergic diseases |
KR1019950700382A KR950702420A (en) | 1992-08-03 | 1993-08-03 | TERFENADINE METABOLITES AND THEIR OPTICALLY PURE ISOMERS FOR TREATING ALLERGIC DISORDERS |
DK02006356T DK1214937T3 (en) | 1992-08-03 | 1993-08-03 | Terfenadine carboxylate and treatment of skin irritation |
DE0701443T DE701443T1 (en) | 1992-08-03 | 1993-08-03 | Terfanadine metabolites and their optically pure isomers for the treatment of allegic diseases |
BR9306841A BR9306841A (en) | 1992-08-03 | 1993-08-03 | Pharmaceutical composition process for providing an antihistamine treatment which does not induce any significant cardiac arrhythmia in a human patient and use of a composition for the manufacture of a medicine for use in an antihistamine treatment |
HU9500313A HU226242B1 (en) | 1992-08-03 | 1993-08-03 | Use of terfenadin carboxylic acid, their salt and optically pure isomers for the preparation of pharmaceutical compositions, and pharmaceutical compositions against allergic disorders |
EP93918584A EP0701443B2 (en) | 1992-08-03 | 1993-08-03 | Terfenadine metabolites and their optically pure isomers for treating allergic disorders |
GB9502183A GB2284351B (en) | 1992-08-03 | 1993-08-03 | Terfenadine metabolites and their optically pure isomers for treating allergic disorders |
DK93918584T DK0701443T4 (en) | 1992-08-03 | 1993-08-03 | Terfenadine metabolites and their optically pure isomers for the treatment of allergic disorders |
SK124-95A SK12495A3 (en) | 1992-08-03 | 1993-08-03 | Drug manufacturing process for use at antihistaminic treatment |
PL93307339A PL174373B1 (en) | 1992-08-03 | 1993-08-03 | Terephandin metabolites and their optically pure isomers for treating allergic disorders |
CA002141572A CA2141572C (en) | 1992-08-03 | 1993-08-03 | Terfenadine metabolites and their optically pure isomers for treating allergic disorders |
NO19950374A NO310644B1 (en) | 1992-08-03 | 1995-02-01 | Use of terfenadine metabolite and its optically pure isomers for the preparation of a pharmaceutical preparation for the treatment of allergic rhinitis |
FI950467A FI950467A (en) | 1992-08-03 | 1995-02-02 | Terfenadine metabolites and their optically pure isomers for the treatment of allergic diseases |
GR960300024T GR960300024T1 (en) | 1992-08-03 | 1996-05-31 | Terfenadine metabolites and their optically pure isomers for treating allergic disorders |
GR980400714T GR3026530T3 (en) | 1992-08-03 | 1998-04-03 | Terfenadine metabolites and their optically pure isomers for treating allergic disorders |
GR20010400247T GR3035417T3 (en) | 1992-08-03 | 2001-02-14 | Terfenadine metabolites and their optically pure isomers for treating allergic disorders |
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US92415692A | 1992-08-03 | 1992-08-03 | |
US92418292A | 1992-08-03 | 1992-08-03 | |
US07/924,182 | 1992-08-03 | ||
US07/924,156 | 1992-08-03 |
Publications (1)
Publication Number | Publication Date |
---|---|
WO1994003170A1 true WO1994003170A1 (en) | 1994-02-17 |
Family
ID=27129882
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/US1993/007260 WO1994003170A1 (en) | 1992-08-03 | 1993-08-03 | Terfenadine metabolites and their optically pure isomers for treating allergic disorders |
Country Status (24)
Country | Link |
---|---|
US (1) | US5375693A (en) |
EP (4) | EP1688142A1 (en) |
JP (6) | JP3041954B2 (en) |
KR (1) | KR950702420A (en) |
AT (3) | ATE322899T1 (en) |
AU (3) | AU675240B2 (en) |
BR (1) | BR9306841A (en) |
CA (1) | CA2141572C (en) |
CZ (1) | CZ27495A3 (en) |
DE (5) | DE69334145T2 (en) |
DK (3) | DK0815860T3 (en) |
ES (3) | ES2284740T3 (en) |
FI (1) | FI950467A (en) |
GB (1) | GB2284351B (en) |
GR (3) | GR960300024T1 (en) |
HK (1) | HK1045806B (en) |
HU (1) | HU226242B1 (en) |
NO (1) | NO310644B1 (en) |
PL (1) | PL174373B1 (en) |
PT (2) | PT815860E (en) |
RO (1) | RO116043B1 (en) |
RU (1) | RU2167657C2 (en) |
SK (1) | SK12495A3 (en) |
WO (1) | WO1994003170A1 (en) |
Cited By (17)
Publication number | Priority date | Publication date | Assignee | Title |
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US5375693A (en) * | 1992-08-03 | 1994-12-27 | Sepracor, Inc. | Methods and compositions for treating allergic disorders and other disorders metabolic derivatives of terfenadine |
WO1995010278A1 (en) * | 1993-10-15 | 1995-04-20 | Hoechst Marion Roussel, Inc. | Treatment of allergic disorders with terfenadine carboxylate |
US5578610A (en) * | 1993-06-24 | 1996-11-26 | Albany Molecular Research, Inc. | Piperidine derivatives |
WO1997002824A1 (en) * | 1995-07-08 | 1997-01-30 | Merck Sharp & Dohme Limited | Use of a tachykinin antagonist and a muscarinic antagonist and/or an antihistamine to treat motion sickness |
EP0818454A1 (en) * | 1996-06-04 | 1998-01-14 | Fabrica Espanola De Productos Quimicos Y Farmaceuticos, S.A. (Faes) | Benzimidazole derivatives with antihistaminic activity |
WO1998033789A1 (en) * | 1997-02-04 | 1998-08-06 | Sepracor, Inc. | Synthesis of terfenadine and derivatives |
US5906747A (en) * | 1995-11-13 | 1999-05-25 | Biosepra Inc. | Separation of molecules from dilute solutions using composite chromatography media having high dynamic sorptive capacity at high flow rates |
US6039974A (en) * | 1997-08-26 | 2000-03-21 | Hoechst Marion Roussel, Inc. | Pharmaceutical composition for combination of piperidinoalkanol-decongestant |
US6113942A (en) * | 1995-02-28 | 2000-09-05 | Aventis Pharmaceuticals Inc. | Pharmaceutical composition for piperidinoalkanol compounds |
US6153754A (en) * | 1995-12-21 | 2000-11-28 | Albany Molecular Research, Inc. | Process for production of piperidine derivatives |
US6201124B1 (en) | 1995-12-21 | 2001-03-13 | Albany Molecular Research, Inc. | Process for production of piperidine derivatives |
US6509353B1 (en) | 1998-04-14 | 2003-01-21 | Sepracor Inc. | Methods and compositions using terfenadine metabolites in combination with leukotriene inhibitors |
US6797826B2 (en) | 1993-06-24 | 2004-09-28 | Amr Technology, Inc. | Piperidine derivatives and process for their production |
US7135571B2 (en) | 1994-05-18 | 2006-11-14 | Aventis Pharmaceuticals, Inc. | Processes for preparing anhydrous and hydrate forms of antihistaminic piperidine derivatives, polymorphs and pseudomorphs thereof |
EP1958935A2 (en) | 2000-11-08 | 2008-08-20 | AMR Technology, Inc. | Process for the production of piperidine derivatives with microorganisms |
US7498443B2 (en) | 2004-09-17 | 2009-03-03 | Albany Molecular Research, Inc. | Process for production of carebastine |
US7498345B2 (en) | 2004-09-17 | 2009-03-03 | Albany Molecular Research, Inc. | Process for production of piperidine derivatives |
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JPH07506828A (en) * | 1992-05-11 | 1995-07-27 | メレルダウファーマス−ティカルズ インコーポレイテッド | Use of terfenazine derivatives as antihistamines in patients with liver damage |
US20030045722A1 (en) * | 1994-05-18 | 2003-03-06 | Henton Daniel R. | Processes for preparing anhydrous and hydrate forms of antihistaminic piperidine derivatives, polymorphs and pseudomorphs thereof |
US5455049A (en) * | 1995-01-04 | 1995-10-03 | Ascent Pharmaceuticals, Inc. | Terfenadine oral powder |
US5837284A (en) * | 1995-12-04 | 1998-11-17 | Mehta; Atul M. | Delivery of multiple doses of medications |
US6486177B2 (en) | 1995-12-04 | 2002-11-26 | Celgene Corporation | Methods for treatment of cognitive and menopausal disorders with D-threo methylphenidate |
US5908850A (en) * | 1995-12-04 | 1999-06-01 | Celgene Corporation | Method of treating attention deficit disorders with d-threo methylphenidate |
US6355656B1 (en) | 1995-12-04 | 2002-03-12 | Celgene Corporation | Phenidate drug formulations having diminished abuse potential |
US5733756A (en) * | 1996-01-05 | 1998-03-31 | Celgene Corporation | Lactams and processes for stereoselective enrichment of lactams, amides, and esters |
US5922736A (en) * | 1995-12-04 | 1999-07-13 | Celegene Corporation | Chronic, bolus administration of D-threo methylphenidate |
US6962997B1 (en) * | 1997-05-22 | 2005-11-08 | Celgene Corporation | Process and intermediates for resolving piperidyl acetamide steroisomers |
DE19913862C2 (en) * | 1999-03-26 | 2003-04-10 | Forschungszentrum Juelich Gmbh | Process for the biocatalyzed conversion of poorly water-soluble substances |
DE10007203A1 (en) * | 2000-02-17 | 2001-08-23 | Asta Medica Ag | Composition for treating allergic and/or vasomotor rhinitis or allergic conjunctivitis by topical or oral administration, contains synergistic combination of non-sedating antihistamine and leukotriene antagonist |
US20020177608A1 (en) * | 2001-04-09 | 2002-11-28 | Ben-Zion Dolitzky | Polymorphs of fexofenadine hydrochloride |
US20030021849A1 (en) * | 2001-04-09 | 2003-01-30 | Ben-Zion Dolitzky | Polymorphs of fexofenadine hydrochloride |
WO2003020274A1 (en) * | 2001-08-30 | 2003-03-13 | Aventis Pharmaceuticals Inc. | Treatment of atopic dermatitis |
AU2003248657A1 (en) * | 2002-06-10 | 2003-12-22 | Teva Pharmaceutical Industries Ltd. | Polymorphic form xvi of fexofenadine hydrochloride |
US20050026890A1 (en) * | 2003-07-31 | 2005-02-03 | Robinson Cynthia B. | Combination of dehydroepiandrosterone or dehydroepiandrosterone-sulfate with an antihistamine for treatment of asthma or chronic obstructive pulmonary disease |
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US20050239830A1 (en) * | 2004-04-26 | 2005-10-27 | Vikram Khetani | Methods of diminishing co-abuse potential |
JP2008514641A (en) * | 2004-09-28 | 2008-05-08 | テバ ファーマシューティカル インダストリーズ リミティド | Crystalline fexofenadine and method for its preparation |
US20060127421A1 (en) * | 2004-12-09 | 2006-06-15 | Celgene Corporation | Treatment using D-threo methylphenidate |
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Citations (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR2453854A1 (en) * | 1979-04-10 | 1980-11-07 | Richardson Merrell Inc | NOVEL O- (4-DIPHENYLMETHYLPIPERIDINO) -1-PHENYLALCANOLS DERIVATIVES, ESPECIALLY USEFUL AS ANTIHISTAMINS, AND THEIR PREPARATION PROCESS |
Family Cites Families (14)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US880801A (en) † | 1908-03-03 | Harold Larsen | Vibrator. | |
US922890A (en) † | 1907-03-26 | 1909-05-25 | Peder Joergen Hansen | Stream-motor. |
US4552899A (en) † | 1984-04-09 | 1985-11-12 | Analgesic Associates | Cough/cold mixtures comprising non-steroidal anti-inflammatory drugs |
US4829064A (en) † | 1987-06-08 | 1989-05-09 | Analgesic Associates | Cough/cold mixtures comprising non-sedating antihistamine drugs |
US4929605A (en) * | 1987-10-07 | 1990-05-29 | Merrell Dow Pharmaceuticals Inc. | Pharmaceutical composition for piperidinoalkanol derivatives |
US4996061A (en) † | 1987-10-07 | 1991-02-26 | Merrell Dow Pharmaceuticals Inc. | Pharmaceutical composition for piperidinoalkanol-decongestant combination |
AU671822B2 (en) * | 1992-04-10 | 1996-09-12 | Aventisub Ii Inc. | 4-diphenylmethyl piperidine derivatives and process for their preparation |
JPH07506828A (en) * | 1992-05-11 | 1995-07-27 | メレルダウファーマス−ティカルズ インコーポレイテッド | Use of terfenazine derivatives as antihistamines in patients with liver damage |
DE69334145T2 (en) | 1992-08-03 | 2008-01-24 | Sepracor Inc., Marlborough | Terfenadine carboxylate and the treatment of skin irritation |
PT1026147E (en) * | 1993-06-24 | 2004-04-30 | Albany Molecular Res Inc | UTERIC COMPOUNDS AS INTERMEDIARIES IN THE PRODUCTION OF PIPERIDINE DERIVATIVES |
WO1995000480A1 (en) * | 1993-06-25 | 1995-01-05 | Merrell Pharmaceuticals Inc. | Novel intermediates for the preparation of antihistaminic 4-diphenylmethyl/diphenylmethoxy piperidine derivatives |
CA2128821A1 (en) * | 1993-07-27 | 1995-01-28 | Dilip J. Gole | Freeze-dried pharmaceutical dosage form and process for separation thereof |
CA2128820A1 (en) * | 1993-07-27 | 1995-01-28 | Walter G. Gowan, Jr. | Rapidly disintegrating pharmaceutical dosage form and process for preparation thereof |
WO1995010278A1 (en) * | 1993-10-15 | 1995-04-20 | Hoechst Marion Roussel, Inc. | Treatment of allergic disorders with terfenadine carboxylate |
-
1993
- 1993-08-03 DE DE69334145T patent/DE69334145T2/en not_active Expired - Lifetime
- 1993-08-03 ES ES02006356T patent/ES2284740T3/en not_active Expired - Lifetime
- 1993-08-03 CA CA002141572A patent/CA2141572C/en not_active Expired - Lifetime
- 1993-08-03 KR KR1019950700382A patent/KR950702420A/en not_active Application Discontinuation
- 1993-08-03 AU AU47986/93A patent/AU675240B2/en not_active Expired
- 1993-08-03 AT AT97104837T patent/ATE322899T1/en active
- 1993-08-03 EP EP06114048A patent/EP1688142A1/en not_active Withdrawn
- 1993-08-03 JP JP6505499A patent/JP3041954B2/en not_active Expired - Lifetime
- 1993-08-03 ES ES93918584T patent/ES2086270T5/en not_active Expired - Lifetime
- 1993-08-03 SK SK124-95A patent/SK12495A3/en unknown
- 1993-08-03 WO PCT/US1993/007260 patent/WO1994003170A1/en active IP Right Grant
- 1993-08-03 DK DK97104837T patent/DK0815860T3/en active
- 1993-08-03 DE DE9320925U patent/DE9320925U1/en not_active Expired - Lifetime
- 1993-08-03 PT PT97104837T patent/PT815860E/en unknown
- 1993-08-03 GB GB9502183A patent/GB2284351B/en not_active Revoked
- 1993-08-03 BR BR9306841A patent/BR9306841A/en not_active Application Discontinuation
- 1993-08-03 DK DK93918584T patent/DK0701443T4/en active
- 1993-08-03 ES ES97104837T patent/ES2257757T3/en not_active Expired - Lifetime
- 1993-08-03 DE DE0701443T patent/DE701443T1/en active Pending
- 1993-08-03 EP EP93918584A patent/EP0701443B2/en not_active Expired - Lifetime
- 1993-08-03 DK DK02006356T patent/DK1214937T3/en active
- 1993-08-03 EP EP97104837A patent/EP0815860B1/en not_active Revoked
- 1993-08-03 DE DE69334008T patent/DE69334008T2/en not_active Expired - Lifetime
- 1993-08-03 RU RU95107881/14A patent/RU2167657C2/en active
- 1993-08-03 HU HU9500313A patent/HU226242B1/en unknown
- 1993-08-03 EP EP02006356A patent/EP1214937B1/en not_active Revoked
- 1993-08-03 RO RO95-00160A patent/RO116043B1/en unknown
- 1993-08-03 AT AT02006356T patent/ATE363283T1/en active
- 1993-08-03 PT PT02006356T patent/PT1214937E/en unknown
- 1993-08-03 DE DE69316660T patent/DE69316660T3/en not_active Expired - Lifetime
- 1993-08-03 AT AT93918584T patent/ATE162399T1/en active
- 1993-08-03 PL PL93307339A patent/PL174373B1/en unknown
-
1994
- 1994-02-02 US US08/191,061 patent/US5375693A/en not_active Expired - Lifetime
-
1995
- 1995-02-01 NO NO19950374A patent/NO310644B1/en not_active IP Right Cessation
- 1995-02-02 FI FI950467A patent/FI950467A/en unknown
- 1995-02-03 CZ CZ95274A patent/CZ27495A3/en unknown
-
1996
- 1996-05-31 GR GR960300024T patent/GR960300024T1/en unknown
- 1996-11-19 AU AU71822/96A patent/AU7182296A/en not_active Abandoned
-
1998
- 1998-04-03 GR GR980400714T patent/GR3026530T3/en unknown
-
1999
- 1999-02-25 AU AU18429/99A patent/AU1842999A/en not_active Abandoned
- 1999-10-13 JP JP11291216A patent/JP2000086512A/en active Pending
- 1999-10-13 JP JP11291230A patent/JP3037697B2/en not_active Expired - Lifetime
- 1999-10-13 JP JP29122399A patent/JP3288661B2/en not_active Expired - Lifetime
- 1999-10-13 JP JP29122899A patent/JP3288662B2/en not_active Expired - Lifetime
- 1999-10-13 JP JP29122099A patent/JP3288660B2/en not_active Expired - Lifetime
-
2001
- 2001-02-14 GR GR20010400247T patent/GR3035417T3/en unknown
-
2002
- 2002-08-17 HK HK02106014.7A patent/HK1045806B/en not_active IP Right Cessation
Patent Citations (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR2453854A1 (en) * | 1979-04-10 | 1980-11-07 | Richardson Merrell Inc | NOVEL O- (4-DIPHENYLMETHYLPIPERIDINO) -1-PHENYLALCANOLS DERIVATIVES, ESPECIALLY USEFUL AS ANTIHISTAMINS, AND THEIR PREPARATION PROCESS |
Non-Patent Citations (16)
Title |
---|
B.TESTA ET AL.: "RACEMATES VERSUS ENANTIOMERS IN DRUG DEVELOPMENT: DOGMATISM OR PRAGMATISM?", CHIRALITY, vol. 2, 1990, pages 129 - 133 * |
D.A.GARTEIZ ET AL.: "PHARMACOKINETICS AND BIOTRANSFORMATION STUDIES OF TERFENADINE IN MAN", ARZNEIM.-FORSCH./DRUG RES., vol. 32(II), no. 9A, 1982, pages 1185 - 1190 * |
E.J.ARIENS: "RACEMIC THERAPEUTICS - ETHICAL AND REGULATORY ASPECTS", EUR.J.CLIN.PHARMACOL., vol. 41, no. 2, 1991, pages 89 - 93 * |
E.J.ARIENS: "RACEMISCHE THERAPEUTICA PROBLEEMMIDDELEN", PHARMACEUTISCH WEEKBLAD, vol. 125, no. 2, 1 June 1990 (1990-06-01), pages 552 - 554 * |
E.J.ARIENS: "STEREOSELECTIVITY IN PHARMACODYNAMICS AND PHARMACOKINETICS", SCHWEIZ.MED.WOCHENSCHR., vol. 120, no. 5, 3 February 1990 (1990-02-03), pages 131 - 134 * |
J.E.COUTANT ET AL.: "DETERMINATION OF TERFENADINE AND TERFENADINE ACID METABOLITE...", J.CHROMATOGRAPHY, vol. 570, no. 1, 18 September 1991 (1991-09-18), pages 139 - 148 * |
K.TASAKA ET AL.: "ANTIALLERGIC EFFECTS OF TERFENADINE...", YAKURI TO CHIRYO, vol. 16, no. 6, 1988, pages 2465 - 2480 * |
K.TASAKA ET AL.: "INTRACELLULAR CALCIUM...", ANN.ALLERGY, vol. 56, no. 6, June 1986 (1986-06-01), pages 464 - 469 * |
K.Y.CHAN ET AL.: "DIRECT ENANTIOMERIC SEPARATION...", J.CHROMATOGRAPHY, vol. 571, no. 1-2, 1991, pages 291 - 297 * |
K.Y.CHAN ET AL.: "LACK OF INTERCONVERSION OF THE ENANTIOMERS OF TERFENADINE IN VIVO...", PHARM.RES., vol. 7, no. SUPP, September 1990 (1990-09-01), pages S222 * |
K.ZAMANI ET AL.: "ENANTIOMERIC ANALYSIS OF TERFENADINE IN RAT PLASMA BY HPLC", CHIRALITY, vol. 3, no. 6, 1991, pages 467 - 470 * |
M.AKAGI ET AL.: "ANTIALLERGIC EFFECTS OF TERFENADINE...", IMMUNOPHARMACOL.IMMUNOTOXICOL., vol. 9, no. 2-3, 1987, pages 259 - 279 * |
P.K.HONIG ET AL.: "CHANGES IN THE PHARMACOKINETICS...", CLIN.PHARMACOL.THER., vol. 52, no. 3, September 1992 (1992-09-01), pages 231 - 238 * |
pages 1550 - 1552 * |
R.L.WOOSLEY: "MECHANISM OF THE CARDIOTOXIC ACTIONS OF TERFENADINE", JAMA, vol. 269, no. 12, 24 March 1993 (1993-03-24), pages 1532 - 1536 * |
T.-M.CHEN ET AL.: "DETERMINATION OF THE METABOLITES OF TERFENADINE...", J.PHARM.BIOMED.ANAL., vol. 9, 1991, pages 929 - 933 * |
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