WO1994004085A3 - Antibiotic eluding intramedulary nail apparatus - Google Patents

Antibiotic eluding intramedulary nail apparatus Download PDF

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Publication number
WO1994004085A3
WO1994004085A3 PCT/US1993/007869 US9307869W WO9404085A3 WO 1994004085 A3 WO1994004085 A3 WO 1994004085A3 US 9307869 W US9307869 W US 9307869W WO 9404085 A3 WO9404085 A3 WO 9404085A3
Authority
WO
WIPO (PCT)
Prior art keywords
bone
antibiotic
intramedullary
fractured
medullary canal
Prior art date
Application number
PCT/US1993/007869
Other languages
French (fr)
Other versions
WO1994004085A2 (en
Inventor
Mark Brinker
Original Assignee
Mark Brinker
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Mark Brinker filed Critical Mark Brinker
Priority to EP94908076A priority Critical patent/EP0655895A4/en
Priority to AU50850/93A priority patent/AU5085093A/en
Publication of WO1994004085A2 publication Critical patent/WO1994004085A2/en
Publication of WO1994004085A3 publication Critical patent/WO1994004085A3/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
    • A61B17/56—Surgical instruments or methods for treatment of bones or joints; Devices specially adapted therefor
    • A61B17/58—Surgical instruments or methods for treatment of bones or joints; Devices specially adapted therefor for osteosynthesis, e.g. bone plates, screws, setting implements or the like
    • A61B17/68—Internal fixation devices, including fasteners and spinal fixators, even if a part thereof projects from the skin
    • A61B17/72—Intramedullary pins, nails or other devices
    • A61B17/7283—Intramedullary pins, nails or other devices with special cross-section of the nail
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
    • A61B17/56—Surgical instruments or methods for treatment of bones or joints; Devices specially adapted therefor
    • A61B17/58—Surgical instruments or methods for treatment of bones or joints; Devices specially adapted therefor for osteosynthesis, e.g. bone plates, screws, setting implements or the like
    • A61B17/68—Internal fixation devices, including fasteners and spinal fixators, even if a part thereof projects from the skin
    • A61B17/72—Intramedullary pins, nails or other devices
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
    • A61L31/14—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A61L31/16—Biologically active materials, e.g. therapeutic substances
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B90/00—Instruments, implements or accessories specially adapted for surgery or diagnosis and not covered by any of the groups A61B1/00 - A61B50/00, e.g. for luxation treatment or for protecting wound edges
    • A61B90/39—Markers, e.g. radio-opaque or breast lesions markers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
    • A61L2300/404—Biocides, antimicrobial agents, antiseptic agents
    • A61L2300/406—Antibiotics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
    • A61L2300/416—Anti-neoplastic or anti-proliferative or anti-restenosis or anti-angiogenic agents, e.g. paclitaxel, sirolimus
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/60—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a special physical form
    • A61L2300/602—Type of release, e.g. controlled, sustained, slow

Abstract

An antibiotic eluding intramedullary nail apparatus (10) for use in the intramedullary fixation of fractured long bones, such as femurs, tibias, fibulas, humeri, ulnas and radii, as well as other orthopedic and bone reconstructive procedures, and, in particular fractures associated with an open wound exposing the soft tissue and medually canal of the fractured bone to bacteria and other infectious micro-organisms. The apparatus (10) has an intramedullary nail to which is secured an antibiotic impregnated carrier compound (20), the apparatus (10) being surgically insertable within the medullary canal of a fractured bone using conventional intramedullary nailing techniques thus providing a sustained localized release of antibiotic agents in bactericidial concentrations, and/or chemotherapeutic agents for bone tumors, directly within the medullary canal of bone tumors, directly within the medullary canal of the fractured bone and thereby serving to permit the use of intramedullary nailing to repair injuries which may be otherwise contraindicated due to the risk of deep wound and/or bone infections and/or bone tumors.
PCT/US1993/007869 1992-08-20 1993-08-20 Antibiotic eluding intramedulary nail apparatus WO1994004085A2 (en)

Priority Applications (2)

Application Number Priority Date Filing Date Title
EP94908076A EP0655895A4 (en) 1992-08-20 1993-08-20 Antibiotic eluding intramedulary nail apparatus.
AU50850/93A AU5085093A (en) 1992-08-20 1993-08-20 Antibiotic eluding intramedulary nail apparatus

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US934,114 1992-08-20
US07/934,114 US5433718A (en) 1992-08-20 1992-08-20 Antibiotic eluding intramedullary nail apparatus

Publications (2)

Publication Number Publication Date
WO1994004085A2 WO1994004085A2 (en) 1994-03-03
WO1994004085A3 true WO1994004085A3 (en) 1994-04-28

Family

ID=25464985

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US1993/007869 WO1994004085A2 (en) 1992-08-20 1993-08-20 Antibiotic eluding intramedulary nail apparatus

Country Status (4)

Country Link
US (2) US5433718A (en)
EP (1) EP0655895A4 (en)
AU (1) AU5085093A (en)
WO (1) WO1994004085A2 (en)

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EP0655895A1 (en) 1995-06-07
AU5085093A (en) 1994-03-15
US5618286A (en) 1997-04-08
WO1994004085A2 (en) 1994-03-03
EP0655895A4 (en) 1996-04-17
US5433718A (en) 1995-07-18

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