WO1994011388A1 - Support for the synthesis of modular polymers - Google Patents
Support for the synthesis of modular polymers Download PDFInfo
- Publication number
- WO1994011388A1 WO1994011388A1 PCT/AU1993/000546 AU9300546W WO9411388A1 WO 1994011388 A1 WO1994011388 A1 WO 1994011388A1 AU 9300546 W AU9300546 W AU 9300546W WO 9411388 A1 WO9411388 A1 WO 9411388A1
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- synthesis
- support
- modular
- peptide
- acid
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
- C07K1/04—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length on carriers
- C07K1/042—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length on carriers characterised by the nature of the carrier
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J19/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
- B01J19/0046—Sequential or parallel reactions, e.g. for the synthesis of polypeptides or polynucleotides; Apparatus and devices for combinatorial chemistry or for making molecular arrays
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
- C07K1/04—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length on carriers
- C07K1/045—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length on carriers using devices to improve synthesis, e.g. reactors, special vessels
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
- B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
- B01J2219/00277—Apparatus
- B01J2219/00279—Features relating to reactor vessels
- B01J2219/00306—Reactor vessels in a multiple arrangement
- B01J2219/00322—Reactor vessels in a multiple arrangement the individual reactor vessels being arranged serially in stacks
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
- B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
- B01J2219/00277—Apparatus
- B01J2219/00497—Features relating to the solid phase supports
- B01J2219/00504—Pins
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
- B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
- B01J2219/00277—Apparatus
- B01J2219/00497—Features relating to the solid phase supports
- B01J2219/00504—Pins
- B01J2219/00506—Pins with removable crowns
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
- B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
- B01J2219/00277—Apparatus
- B01J2219/0054—Means for coding or tagging the apparatus or the reagents
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
- B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
- B01J2219/00277—Apparatus
- B01J2219/0054—Means for coding or tagging the apparatus or the reagents
- B01J2219/00545—Colours
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
- B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
- B01J2219/00277—Apparatus
- B01J2219/0054—Means for coding or tagging the apparatus or the reagents
- B01J2219/00554—Physical means
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
- B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
- B01J2219/00277—Apparatus
- B01J2219/0054—Means for coding or tagging the apparatus or the reagents
- B01J2219/00563—Magnetic means
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
- B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
- B01J2219/00583—Features relative to the processes being carried out
- B01J2219/00596—Solid-phase processes
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
- B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
- B01J2219/00718—Type of compounds synthesised
- B01J2219/0072—Organic compounds
- B01J2219/00725—Peptides
-
- C—CHEMISTRY; METALLURGY
- C40—COMBINATORIAL TECHNOLOGY
- C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
- C40B40/00—Libraries per se, e.g. arrays, mixtures
- C40B40/04—Libraries containing only organic compounds
- C40B40/10—Libraries containing peptides or polypeptides, or derivatives thereof
-
- C—CHEMISTRY; METALLURGY
- C40—COMBINATORIAL TECHNOLOGY
- C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
- C40B60/00—Apparatus specially adapted for use in combinatorial chemistry or with libraries
- C40B60/14—Apparatus specially adapted for use in combinatorial chemistry or with libraries for creating libraries
-
- C—CHEMISTRY; METALLURGY
- C40—COMBINATORIAL TECHNOLOGY
- C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
- C40B70/00—Tags or labels specially adapted for combinatorial chemistry or libraries, e.g. fluorescent tags or bar codes
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Analytical Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Peptides Or Proteins (AREA)
- Polyoxymethylene Polymers And Polymers With Carbon-To-Carbon Bonds (AREA)
- Graft Or Block Polymers (AREA)
- Addition Polymer Or Copolymer, Post-Treatments, Or Chemical Modifications (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
Description
Claims
Priority Applications (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP93923418A EP0672049A4 (en) | 1992-11-06 | 1993-10-25 | Support for the synthesis of modular polymers. |
AU53315/94A AU680450B2 (en) | 1992-11-06 | 1993-10-25 | Support for the synthesis of modular polymers |
JP6511520A JPH08505604A (en) | 1992-11-06 | 1993-10-25 | Support for synthesizing modular polymers |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US97275592A | 1992-11-06 | 1992-11-06 | |
US07/972,755 | 1992-11-06 |
Publications (1)
Publication Number | Publication Date |
---|---|
WO1994011388A1 true WO1994011388A1 (en) | 1994-05-26 |
Family
ID=25520079
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/AU1993/000546 WO1994011388A1 (en) | 1992-11-06 | 1993-10-25 | Support for the synthesis of modular polymers |
Country Status (7)
Country | Link |
---|---|
EP (1) | EP0672049A4 (en) |
JP (1) | JPH08505604A (en) |
AU (2) | AU680450B2 (en) |
CA (1) | CA2148591A1 (en) |
HU (1) | HUT73150A (en) |
NZ (1) | NZ257077A (en) |
WO (1) | WO1994011388A1 (en) |
Cited By (19)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5609826A (en) * | 1995-04-17 | 1997-03-11 | Ontogen Corporation | Methods and apparatus for the generation of chemical libraries |
WO1998018550A1 (en) * | 1996-10-30 | 1998-05-07 | Chiron Corporation | Transponder tagging of constituents used in compound synthesis |
WO1998038158A1 (en) * | 1997-02-26 | 1998-09-03 | Eli Lilly And Company | Process for preparing pharmaceutical compounds |
WO1999034214A1 (en) * | 1997-12-31 | 1999-07-08 | Qiagen Genomics, Inc | Solid-phase tips and uses relating thereto |
US5961923A (en) * | 1995-04-25 | 1999-10-05 | Irori | Matrices with memories and uses thereof |
US6054264A (en) * | 1993-05-10 | 2000-04-25 | Chiron Corporation | Methods of typing hepatitis C virus and reagents for use therein |
EP1018365A2 (en) * | 1995-10-26 | 2000-07-12 | University Of Hertfordshire | Coded particles for process sequence tracking in combinatorial compound library preparation |
US6100026A (en) * | 1995-04-25 | 2000-08-08 | Irori | Matrices with memories and uses thereof |
US6171555B1 (en) | 1995-04-17 | 2001-01-09 | Ontogen Corporation | Reaction block docking station |
US6284459B1 (en) | 1995-04-25 | 2001-09-04 | Discovery Partners International | Solid support matrices with memories and combinatorial libraries therefrom |
US6362009B1 (en) | 1997-11-21 | 2002-03-26 | Merck & Co., Inc. | Solid phase synthesis of heterocycles |
US6365349B1 (en) | 1997-07-22 | 2002-04-02 | Qiagen Genomics, Inc. | Apparatus and methods for arraying solution onto a solid support |
EP1235766A1 (en) * | 1999-11-24 | 2002-09-04 | Aventis Pharmaceuticals Inc. | Apparatus and method for synthesizing combinatorial libraries |
WO2003039750A1 (en) * | 2001-11-07 | 2003-05-15 | Genvault Corporation | Apparatus, system, and method of archival and retrieval of samples |
US7584240B2 (en) | 2001-11-07 | 2009-09-01 | Genvault Corporation | Automated biological sample archive for storage, retrieval and analysis of large numbers of samples for remote clients |
US7718442B2 (en) | 2002-11-22 | 2010-05-18 | Genvault Corporation | Sealed sample storage element system and method |
US8273304B2 (en) | 1996-01-16 | 2012-09-25 | Affymetrix, Inc. | Analytical biochemistry system with robotically carried bioarray |
US8283165B2 (en) | 2008-09-12 | 2012-10-09 | Genvault Corporation | Matrices and media for storage and stabilization of biomolecules |
US8431384B2 (en) | 2004-05-24 | 2013-04-30 | Genvault Corporation | Stable protein storage and stable nucleic acid storage in recoverable form |
Citations (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1984002526A1 (en) * | 1982-12-29 | 1984-07-05 | Univ Southern Illinois | Process for producing polynucleotides |
US4515920A (en) * | 1984-04-30 | 1985-05-07 | The Rockefeller University | Synthesis of peptides and proteins |
AU2542984A (en) * | 1983-03-08 | 1985-11-14 | Chiron Mimotopes Pty Ltd | Method of determining antigenically active amino acid sequences |
AU4856185A (en) * | 1984-10-18 | 1986-04-24 | F. Hoffmann-La Roche Ag | Multi chamber reactor |
AU1226088A (en) * | 1987-01-06 | 1988-07-27 | Baylor College Of Medicine | Porous wafer for segmented synthesis of biopolymers |
AU7645687A (en) * | 1987-03-11 | 1988-10-10 | Samuel L. Steel | Synthesis of peptide analogs |
AU4986990A (en) * | 1989-02-17 | 1990-08-23 | Coselco Mimotopes Pty Ltd | Method for the use and synthesis of peptides |
AU6359390A (en) * | 1989-09-15 | 1991-04-18 | Coselco Mimotopes Pty Ltd | Solid surface for peptide synthesis |
DE3935572A1 (en) * | 1989-10-25 | 1991-05-02 | Biotechnolog Forschung Gmbh | METHOD FOR PEPTID SYNTHESIS AND SUPPORT FOR THIS |
Family Cites Families (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5143854A (en) * | 1989-06-07 | 1992-09-01 | Affymax Technologies N.V. | Large scale photolithographic solid phase synthesis of polypeptides and receptor binding screening thereof |
-
1993
- 1993-10-25 CA CA002148591A patent/CA2148591A1/en not_active Abandoned
- 1993-10-25 JP JP6511520A patent/JPH08505604A/en active Pending
- 1993-10-25 HU HU9501322A patent/HUT73150A/en unknown
- 1993-10-25 WO PCT/AU1993/000546 patent/WO1994011388A1/en not_active Application Discontinuation
- 1993-10-25 NZ NZ257077A patent/NZ257077A/en unknown
- 1993-10-25 EP EP93923418A patent/EP0672049A4/en not_active Withdrawn
- 1993-10-25 AU AU53315/94A patent/AU680450B2/en not_active Ceased
-
1997
- 1997-05-16 AU AU22806/97A patent/AU2280697A/en not_active Abandoned
Patent Citations (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1984002526A1 (en) * | 1982-12-29 | 1984-07-05 | Univ Southern Illinois | Process for producing polynucleotides |
AU2542984A (en) * | 1983-03-08 | 1985-11-14 | Chiron Mimotopes Pty Ltd | Method of determining antigenically active amino acid sequences |
US4515920A (en) * | 1984-04-30 | 1985-05-07 | The Rockefeller University | Synthesis of peptides and proteins |
AU4856185A (en) * | 1984-10-18 | 1986-04-24 | F. Hoffmann-La Roche Ag | Multi chamber reactor |
AU1226088A (en) * | 1987-01-06 | 1988-07-27 | Baylor College Of Medicine | Porous wafer for segmented synthesis of biopolymers |
AU7645687A (en) * | 1987-03-11 | 1988-10-10 | Samuel L. Steel | Synthesis of peptide analogs |
AU4986990A (en) * | 1989-02-17 | 1990-08-23 | Coselco Mimotopes Pty Ltd | Method for the use and synthesis of peptides |
AU6359390A (en) * | 1989-09-15 | 1991-04-18 | Coselco Mimotopes Pty Ltd | Solid surface for peptide synthesis |
DE3935572A1 (en) * | 1989-10-25 | 1991-05-02 | Biotechnolog Forschung Gmbh | METHOD FOR PEPTID SYNTHESIS AND SUPPORT FOR THIS |
Non-Patent Citations (1)
Title |
---|
See also references of EP0672049A4 * |
Cited By (29)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6416946B1 (en) | 1993-05-10 | 2002-07-09 | Chiron Corporation | Methods of typing hepatitis C virus and reagents for use therein |
US6416944B1 (en) | 1993-05-10 | 2002-07-09 | Chiron Corporation | Methods of typing hepatitis C virus and reagents for use therein |
US6054264A (en) * | 1993-05-10 | 2000-04-25 | Chiron Corporation | Methods of typing hepatitis C virus and reagents for use therein |
US5770157A (en) * | 1995-04-17 | 1998-06-23 | Ontogen Corporation | Methods and apparatus for the generation of chemical libraries |
US5609826A (en) * | 1995-04-17 | 1997-03-11 | Ontogen Corporation | Methods and apparatus for the generation of chemical libraries |
US6171555B1 (en) | 1995-04-17 | 2001-01-09 | Ontogen Corporation | Reaction block docking station |
US6284459B1 (en) | 1995-04-25 | 2001-09-04 | Discovery Partners International | Solid support matrices with memories and combinatorial libraries therefrom |
US5961923A (en) * | 1995-04-25 | 1999-10-05 | Irori | Matrices with memories and uses thereof |
US6100026A (en) * | 1995-04-25 | 2000-08-08 | Irori | Matrices with memories and uses thereof |
EP1018365A2 (en) * | 1995-10-26 | 2000-07-12 | University Of Hertfordshire | Coded particles for process sequence tracking in combinatorial compound library preparation |
EP1018365A3 (en) * | 1995-10-26 | 2000-10-11 | University Of Hertfordshire | Coded particles for process sequence tracking in combinatorial compound library preparation |
US8273304B2 (en) | 1996-01-16 | 2012-09-25 | Affymetrix, Inc. | Analytical biochemistry system with robotically carried bioarray |
US6265219B1 (en) | 1996-10-30 | 2001-07-24 | Mitokor | Transponder tagging of constituents used in compound synthesis |
AU732405B2 (en) * | 1996-10-30 | 2001-04-26 | Mimotopes Pty Ltd | Transponder tagging of constituents used in compound synthesis |
WO1998018550A1 (en) * | 1996-10-30 | 1998-05-07 | Chiron Corporation | Transponder tagging of constituents used in compound synthesis |
WO1998038158A1 (en) * | 1997-02-26 | 1998-09-03 | Eli Lilly And Company | Process for preparing pharmaceutical compounds |
US6365349B1 (en) | 1997-07-22 | 2002-04-02 | Qiagen Genomics, Inc. | Apparatus and methods for arraying solution onto a solid support |
US6362009B1 (en) | 1997-11-21 | 2002-03-26 | Merck & Co., Inc. | Solid phase synthesis of heterocycles |
WO1999034214A1 (en) * | 1997-12-31 | 1999-07-08 | Qiagen Genomics, Inc | Solid-phase tips and uses relating thereto |
EP1235766A1 (en) * | 1999-11-24 | 2002-09-04 | Aventis Pharmaceuticals Inc. | Apparatus and method for synthesizing combinatorial libraries |
EP1235766A4 (en) * | 1999-11-24 | 2006-05-24 | Aventis Pharma Inc | Apparatus and method for synthesizing combinatorial libraries |
WO2003039750A1 (en) * | 2001-11-07 | 2003-05-15 | Genvault Corporation | Apparatus, system, and method of archival and retrieval of samples |
US7584240B2 (en) | 2001-11-07 | 2009-09-01 | Genvault Corporation | Automated biological sample archive for storage, retrieval and analysis of large numbers of samples for remote clients |
US7718442B2 (en) | 2002-11-22 | 2010-05-18 | Genvault Corporation | Sealed sample storage element system and method |
US8431384B2 (en) | 2004-05-24 | 2013-04-30 | Genvault Corporation | Stable protein storage and stable nucleic acid storage in recoverable form |
US8283165B2 (en) | 2008-09-12 | 2012-10-09 | Genvault Corporation | Matrices and media for storage and stabilization of biomolecules |
US8951719B2 (en) | 2008-09-12 | 2015-02-10 | Gentegra, LLC. | Matrices and media for storage and stabilization of biomolecules |
US9637513B2 (en) | 2008-09-12 | 2017-05-02 | Gentegra Llc | Matrices and media for storage and stabilization of biomolecules |
US10160997B2 (en) | 2008-09-12 | 2018-12-25 | Gentegra Llc | Matrices and media for storage and stabilization of biomolecules |
Also Published As
Publication number | Publication date |
---|---|
AU680450B2 (en) | 1997-07-31 |
JPH08505604A (en) | 1996-06-18 |
CA2148591A1 (en) | 1994-05-26 |
HUT73150A (en) | 1996-06-28 |
AU2280697A (en) | 1997-08-28 |
NZ257077A (en) | 1997-05-26 |
EP0672049A4 (en) | 1997-10-15 |
AU5331594A (en) | 1994-06-08 |
HU9501322D0 (en) | 1995-06-28 |
EP0672049A1 (en) | 1995-09-20 |
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