WO1994013342A1 - A device preset for the automatic intradermal administration of a drug - Google Patents

A device preset for the automatic intradermal administration of a drug Download PDF

Info

Publication number
WO1994013342A1
WO1994013342A1 PCT/IT1992/000166 IT9200166W WO9413342A1 WO 1994013342 A1 WO1994013342 A1 WO 1994013342A1 IT 9200166 W IT9200166 W IT 9200166W WO 9413342 A1 WO9413342 A1 WO 9413342A1
Authority
WO
WIPO (PCT)
Prior art keywords
syringe
piston
drug
spring
plunger
Prior art date
Application number
PCT/IT1992/000166
Other languages
French (fr)
Inventor
Ermanno Greco
Original Assignee
Ermanno Greco
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ermanno Greco filed Critical Ermanno Greco
Priority to AU33662/93A priority Critical patent/AU3366293A/en
Publication of WO1994013342A1 publication Critical patent/WO1994013342A1/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/20—Automatic syringes, e.g. with automatically actuated piston rod, with automatic needle injection, filling automatically
    • A61M5/2033—Spring-loaded one-shot injectors with or without automatic needle insertion
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/20—Automatic syringes, e.g. with automatically actuated piston rod, with automatic needle injection, filling automatically
    • A61M2005/2006—Having specific accessories
    • A61M2005/202—Having specific accessories cocking means, e.g. to bias the main drive spring of an injector
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/46—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests having means for controlling depth of insertion

Definitions

  • Said devices housing a syringe of a predetermined size, which may be previously loaded with the drug required by the patient and kept ready for use.
  • Said devices are generally cylinder-shaped and resemble a pen enabling the intradermal injection of the drug, thanks to the special mechanisms housed inside.
  • the object of this invention is a device specifically preset for the automatic intrader al administration of a drug, which remedies the aforesaid drawbacks, allowing a considerable improvement of its functionality.
  • the device described herein essentially consists of a pen-shaped container, preferably made of a- plastic material and made up of two parts joined the one to the other by means of a bayonet or screw joint.
  • the top part of the device houses the piston which drives the syringe plunger, the springs allowing this operation and the safety mechanisms which enable the return of the syringe needle inside the bottom part.
  • the syringe housing In the bottom part of the device there is the syringe housing, which is provided with a coaxial sliding element, which moves along the longitudinal axis of the device.
  • figs. 3 and 5 show a sectional view of the releasing mechanism sequence
  • fig. 6 shows the mechanism which stops the syringe inside the lower part of the device
  • fig. 7 shows a sectional view of the entire device, with the position of the automatic syringe return mechanism, during the injection
  • fig. 8 shows a sectional view of the entire device with the position of the automatic syringe return mechanism after the injection
  • figs. 9 and 10 show a sectional view of two positions of the automatic syringe return mechanism.
  • the device described herein is very useful for those patients, who require injections at very short notice, without having to carry around a syringe with the drug to be injected.
  • the device described herein In order to work correctly the device described herein, as also those already on the market, must be prepared beforehand with the drug and set in such a manner as to be immediately usable whenever required.
  • the bottom part 1 shown in fig. 6, from the top part 2, shown in fig. 1.
  • these two elements are joined together by means of a screw or bayonet joint.
  • the bottom part 1 houses the syringe 3 which, having been loaded beforehand with the required dug, presents the plunger 4 ready to inject th ⁇ drug through the needle.
  • a third gasket 24 is also placed in a specific cut between the top part of the syringe 3 and the edge of its housing, in order to prevent any damage to * the top part of the syringe when the piston starts pushing the plunger and the syringe reaches its lower counterborin .
  • the automatic return mechanism of the syringe is shown in figs. 7, 8, 9 and 10.
  • Fig. 7 shows the spring 18 in its preloaded position, said preloading having been achieved by pulling down the piston 19, before pushing it upwards for loading the spring 13, which pushes the piston 19 when the drug must be injected.
  • the spring 18, which enables the return of the syringe and, therefore, the return of the needle 22 inside the device, is kept compressed after the loading, between the counterboring 20 and the backstop 21, assisted in its action by the spherical element 21'.
  • the piston 19 has pushed the plunger 4 of the syringe up to the end of its stroke, i.e., at the end of the. injection, the top of the piston 19 causes the backstop 21 to move, thus freeing the previously compressed spring 18 which, taking on the position shown in fig. 8, pulls up the syringe 3 and, consequently, the needle 22 also, which is hidden inside the device, preventing any further accidental contact.
  • the traction of the piston 19, therefore, precedes the compression of the piston 19, which is required to load the spring 13 and set the device for working automatically when the cap 5 is pressed.
  • the pressure on the cap 5 frees the spring .13 which then discharges its compressed strength onto the piston 19 which pushes the plunger 4, as previously described, and, consequently the syringe 3 and the needle 22 out of the device, thus executing the injection.
  • a safety lock shown in figs. 1 and 2 has been provided for.
  • a pin 7 is attached to the cap 5 which, in the safety lock position, engages in the horizontal part 9 of the slot 8 (shown in the fig. 2), provided for on the" inside body to which the cap 5 is fixed but free to rotate; when it is in this position, even if the cap 5 is pressed it will not move.
  • the pin 7 moves to the vertical part 10 of the slot 8 and, therefore, the cap 5 is free to move downwards when pressed.
  • the slot 8 ends on the left side with a vertical groove which acts as a sort of stop and which obliges the user to exert a light pressure in order to return to the previous position.
  • the cap 5 when pressed, moves down automatically triggering the mechanism illustrated in figs. 3, 4 and 5.
  • the spherical element blocks, the backstop 12, at the top end of the piston 19, thus forcing the spring 13 to remain compressed; the pressure on the cap 5 makes sure that the spherical element 11, pushed by the particular shape of the top end 12 of the piston 19, moves into the housing 14, which it encounters in its path during its movement downwards, enabling the piston 19, pushed by the spring 13, to discharge all its strength onto the plunger 4 of the syringe 3 causing with a single movement the exit of the needle from the device and the intradermal injection of the drug into the patient.

Abstract

The device preset for the automatic intradermal administration of a drug consists of a pen-shaped body formed of a bottom part (1) and a top part (2) joined together by means of a screw or a bayonet or a similar joint; the pressure applied to a button (5) frees a piston (19), to which a force is imparted by means of a preloaded spring (13), which strikes and pushes the plunger (4) of a syringe (3) housed in the bottom part (1) of the device and loaded with the drug required by the patient, thus causing the syringe needle to come out of the tip and inject the drug.

Description

Descrj-p-tion "A DEVICE PRESET FOR THE AUTOMATIC INTRADERMAL
ADMINISTRATION OF A DRUG"
* * * *
' Backgrou-ticL Art
For several years now some specialized firms have devised and marketed devices housing a syringe of a predetermined size, which may be previously loaded with the drug required by the patient and kept ready for use. Said devices are generally cylinder-shaped and resemble a pen enabling the intradermal injection of the drug, thanks to the special mechanisms housed inside.
The devices briefly described above have proved very useful because, as previously mentioned, they enable a person to have a loaded syringe always ready at hand, to be used whenever required.
Devices of the aforesaid type marketed to date, however, present a series of drawbacks which may jeopardize their safe operation. Some of the marketed devices, for example, have had problems with the releasing mechanism of the small piston, which determines the injection of the drug, and with the safety lock, which prevents the accidental release of said piston; furthermore, it has been seen that, in order to achieve optimal working conditions of the device, it is necessary to prevent even the smallest movement of the syringe inside the container, during both the preparation of the device (loading the device with the syringe and reassembly of the component elements) and the injection of the drug. Furthermore, it has also been seen that it is necessary to modify the needle depth regulation system, besides providing for a mechanism allowing the automatic return of the needle inside the container after use, in ...ccordance with the new legislation on this matter.
The previous patent application filed by the same patent holder describes a device the body of which resembles a pen and the inside of which houses a syringe loaded with the required drug; said device, although functional, nevertheless also presents the aforesaid drawbacks.
- ~ "
Disclos-ure of Invention
The object of this invention is a device specifically preset for the automatic intrader al administration of a drug, which remedies the aforesaid drawbacks, allowing a considerable improvement of its functionality.
The device described herein essentially consists of a pen-shaped container, preferably made of a- plastic material and made up of two parts joined the one to the other by means of a bayonet or screw joint. The top part of the device houses the piston which drives the syringe plunger, the springs allowing this operation and the safety mechanisms which enable the return of the syringe needle inside the bottom part.
In the bottom part of the device there is the syringe housing, which is provided with a coaxial sliding element, which moves along the longitudinal axis of the device.
This sliding element tends to be held up by a spring placed between the bottom part of the element itself and the bottom part of the device, the tip of which is shaped like a truncated cone. A small -lever, accessible from the outside, which moves inside a_ slot and is integral with the sliding element, allows the preparation of the syringe for the injection by removing the small cap which protects the needle. The foregoing brief description may be better understood by reading the more detailed description which follows, with reference to the attached drawings, in which: fig. 1 shows a sectional view of the top part of the device and, in particular, of the safety mechanism; fig. 2 shows the horizontal section of a detail of the safety mechanism; figs. 3, 4 and 5 show a sectional view of the releasing mechanism sequence; fig. 6 shows the mechanism which stops the syringe inside the lower part of the device; fig. 7 shows a sectional view of the entire device, with the position of the automatic syringe return mechanism, during the injection; fig. 8 shows a sectional view of the entire device with the position of the automatic syringe return mechanism after the injection; lastly, figs. 9 and 10 show a sectional view of two positions of the automatic syringe return mechanism.
As previously mentioned, the" device described herein is very useful for those patients, who require injections at very short notice, without having to carry around a syringe with the drug to be injected. In order to work correctly the device described herein, as also those already on the market, must be prepared beforehand with the drug and set in such a manner as to be immediately usable whenever required.
In order to prepare the device it is first of all necessary to separate the two component parts, i.e., the bottom part 1 shown in fig. 6, from the top part 2, shown in fig. 1. As previously described, these two elements are joined together by means of a screw or bayonet joint. The bottom part 1 houses the syringe 3 which, having been loaded beforehand with the required dug, presents the plunger 4 ready to inject thβ drug through the needle. In order to prevent the syringe from making even the slightest movement inside the container 1 there are two ring-shaped or similar gaskets 24 made of rubber and placed inside suitably deep cuts made at angles of 120 degrees the one to the other; said location of the gaskets 24 ensures that the syringe 3 may be placed inside the container 1 without having to exert an excessive pressure thanks to the elastic nature of the gaskets, which also keep the syringe in place during the preparatory phase, preventing it from accidentally moving down or from making any movement whatsoever during the injection. A third gasket 24 is also placed in a specific cut between the top part of the syringe 3 and the edge of its housing, in order to prevent any damage to *the top part of the syringe when the piston starts pushing the plunger and the syringe reaches its lower counterborin .
When the syringe 3 has been loaded and the rod (not shown) enabling the manual working of the plunger 4 has been unscrewed, said plunger 4 will find itself at the end of the thread of the bottom part of the container. After having placed the syringe 3 in its ITousing and before loading the piston 19 which will push the plunger 4 of the syringe 3 during the injection, it is necessary also to prepare the system which will allow the automatic return of the syringe 3 after the injection.
The automatic return mechanism of the syringe is shown in figs. 7, 8, 9 and 10.
Fig. 7 shows the spring 18 in its preloaded position, said preloading having been achieved by pulling down the piston 19, before pushing it upwards for loading the spring 13, which pushes the piston 19 when the drug must be injected.
The spring 18, which enables the return of the syringe and, therefore, the return of the needle 22 inside the device, is kept compressed after the loading, between the counterboring 20 and the backstop 21, assisted in its action by the spherical element 21'. When, as shown in fig. 7, the piston 19 has pushed the plunger 4 of the syringe up to the end of its stroke, i.e., at the end of the. injection, the top of the piston 19 causes the backstop 21 to move, thus freeing the previously compressed spring 18 which, taking on the position shown in fig. 8, pulls up the syringe 3 and, consequently, the needle 22 also, which is hidden inside the device, preventing any further accidental contact.
The traction of the piston 19, therefore, precedes the compression of the piston 19, which is required to load the spring 13 and set the device for working automatically when the cap 5 is pressed. The pressure on the cap 5 frees the spring .13 which then discharges its compressed strength onto the piston 19 which pushes the plunger 4, as previously described, and, consequently the syringe 3 and the needle 22 out of the device, thus executing the injection.
In order to prevent the accidental triggering of the cap 5, a safety lock shown in figs. 1 and 2 has been provided for. These figures clearly show that a pin 7 is attached to the cap 5 which, in the safety lock position, engages in the horizontal part 9 of the slot 8 (shown in the fig. 2), provided for on the" inside body to which the cap 5 is fixed but free to rotate; when it is in this position, even if the cap 5 is pressed it will not move. By rotating the cap 5 for a certain angle, the pin 7 moves to the vertical part 10 of the slot 8 and, therefore, the cap 5 is free to move downwards when pressed.
The slot 8 ends on the left side with a vertical groove which acts as a sort of stop and which obliges the user to exert a light pressure in order to return to the previous position.
Once the safety lock has been removed by rotation, the cap 5, when pressed, moves down automatically triggering the mechanism illustrated in figs. 3, 4 and 5. As may be seen in fig. 3, when the cap 5 is in the safety position the spherical element blocks, the backstop 12, at the top end of the piston 19, thus forcing the spring 13 to remain compressed; the pressure on the cap 5 makes sure that the spherical element 11, pushed by the particular shape of the top end 12 of the piston 19, moves into the housing 14, which it encounters in its path during its movement downwards, enabling the piston 19, pushed by the spring 13, to discharge all its strength onto the plunger 4 of the syringe 3 causing with a single movement the exit of the needle from the device and the intradermal injection of the drug into the patient.
It is possible to vary the amount of the needle which comes out of the device and, therefore, the depth of penetration of the same by means of a thread between the runner 25 and the tip of the device.

Claims

C A I M S
1. A device specifically preset for the automatic intradermal administration of a drug, with a pen-shaped body consisting of a bottom and a top part joined together by means of a screw or a bayonet or similar joint; the pressure applied to a button frees a piston, to which a force is imparted by means of a -preloaded spring, which strikes and pushes the plunger of a syringe housed in the bottom part of the device and loaded with the drug required by the patient, thus causing the syringe needle to come out, of the tip and inject the drug.
2. A device specifically preset for the automatic intradermal administration of a drug, as per claim 1, characterized by the fact that the piston 19, which pushes the plunger ,4 of the syringe 3, before being pushed in order to compress the spring 13 which enables it to perform the injection when the patient pushes the releasing button, is pulled in order to compress the spring 18, which remains in such a position of compression until the top part σf the piston 19, as soon as said piston has finished pushing the plunger 4 of the syringe 3, determines the movement of the backstop 21 and the consequent liberation of the spring 18 which pulls the entire syringe 3 and, consequently, the needle 22, back inside the device.
3. A device specifically preset for the automatic intradermal administration of a drug, characterized by the fact that a safety lock has been specifically provided for, in order to prevent the accidental triggering of the releasing mechanism of the piston 19, once said mechanism has been loaded and the" syringe containing the drug has been inserted in its housing in the bottom part of the device; said safety lock consists of a pin 7 attached to the cap 5, the latter functioning as a releasing button. The pin 7, in the safety position, engages in the horizontal part 9 of the slot 8 provided for inside the part of the device to which the cap 8 is fixed although free to rotate; by rotating the cap 5 the pin 7 meets the vertical part 10 of the slot 8 and overcoming the weak resistance offered by the spring 23 the piston 19 releasing mechanism is triggered.
4. A device specifically preset for the automatic intradermal administration of a drug, as per the previous claims, characterized by the fact that the downwards movement of the cap 5 triggers the releasing mechanism of the piston 19; in the safety position of the cap 5 the spherical element 11 blocks the backstop 12 forcing the spring 13 which drives the piston 19 to remain in a compressed position, the pressure on the cap 5 determines 42 - 1 1 - rU'
that the spherical element 11 pushed by the top obliquely-shaped part of the piston 19 move into the specific housing 14 leaving the piston 19 driven by the spring 13 the possibility of unloading its strength on the plunger 4 of the syringe 3, thus causing, with a single movement, the ejection of the needle 22 from the hole specifically provided for at the tip of the device and the injection of the drug caused by the plunger 4 of the syringe 3, pushed by the piston 19.
5. A device specifically preset for the automatic intradermal administration of a drug, characterized by the fact that, in order to prevent even the slightest movement of the syringe inside the device, rubber ring- shaped or similar gaskets have been introduced inside specific housings in the lower part of the device, housings consisting of cuts made at 120 degrees the one from the other, so as to maintain a considerable degree of elasticity. A further gasket has been provided for between the upper part of the syringe 3 and the edge of the syringe housing, so as to prevent any damage to the upper part of the syringe when the piston starts pushing the plunger and the syringe reaches the lower counterboring.
PCT/IT1992/000166 1992-12-11 1992-12-18 A device preset for the automatic intradermal administration of a drug WO1994013342A1 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU33662/93A AU3366293A (en) 1992-12-11 1992-12-18 A device preset for the automatic intradermal administration of a drug

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
ITRM92A000881921211 1992-12-11
ITRM920881A IT1256577B (en) 1992-12-11 1992-12-11 DEVICE PREPARED FOR THE AUTOMATIC ADMINISTRATION OF A DRUG VIA INTRADERMIC.

Publications (1)

Publication Number Publication Date
WO1994013342A1 true WO1994013342A1 (en) 1994-06-23

Family

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Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/IT1992/000166 WO1994013342A1 (en) 1992-12-11 1992-12-18 A device preset for the automatic intradermal administration of a drug

Country Status (3)

Country Link
AU (1) AU3366293A (en)
IT (1) IT1256577B (en)
WO (1) WO1994013342A1 (en)

Cited By (46)

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WO1999022792A1 (en) * 1997-11-03 1999-05-14 Ermanno Greco Self-injection device
WO2000024441A1 (en) * 1998-10-26 2000-05-04 Pharmacia Ab Autoinjector
US6203530B1 (en) 1997-01-28 2001-03-20 Pos-T-Vac, Inc. Auto-injection device
EP1104683A1 (en) * 1999-12-03 2001-06-06 Mattern, Udo Device for the injection of antiparasitic agents into pet animals
WO2003039634A1 (en) 2001-11-09 2003-05-15 Alza Corporation Pneumatic powered autoinjector
WO2003041770A2 (en) * 2001-11-09 2003-05-22 Alza Corporation Collapsible syringe cartridge
WO2004067068A1 (en) * 2003-01-24 2004-08-12 Alza Corporation Collapsible syringe cartridge
US7381201B2 (en) 2002-06-24 2008-06-03 Alza Corporation Reusable, spring driven autoinjector
GB2463034A (en) * 2008-08-28 2010-03-03 Owen Mumford Ltd Auto-injection device with locking member and shield
US8162887B2 (en) 2004-06-23 2012-04-24 Abbott Biotechnology Ltd. Automatic injection devices
US8277414B2 (en) 2004-05-28 2012-10-02 Cilag Gmbh International Injection device
US8313464B2 (en) 2004-05-28 2012-11-20 Cilag Gmbh International Injection device
US8313465B2 (en) 2004-05-28 2012-11-20 Cilag Gmbh International Injection device
US8313463B2 (en) 2004-05-28 2012-11-20 Cilag Gmbh International Injection device
US8343110B2 (en) 2004-05-28 2013-01-01 Cilag Gmbh International Injection device
US8591457B2 (en) 2005-08-10 2013-11-26 Alza Corporation Method for making a needle-free jet injection drug delivery device
US8636704B2 (en) 2009-04-29 2014-01-28 Abbvie Biotechnology Ltd Automatic injection device
WO2014029621A1 (en) * 2012-08-20 2014-02-27 Carebay Europe Ltd Automatic injection device
US8679061B2 (en) 2006-06-30 2014-03-25 Abbvie Biotechnology Ltd Automatic injection device
US8708968B2 (en) 2011-01-24 2014-04-29 Abbvie Biotechnology Ltd. Removal of needle shields from syringes and automatic injection devices
US8758301B2 (en) 2009-12-15 2014-06-24 Abbvie Biotechnology Ltd Firing button for automatic injection device
US8834419B2 (en) 2008-06-19 2014-09-16 Cilag Gmbh International Reusable auto-injector
US8845594B2 (en) 2008-06-19 2014-09-30 Cilag Gmbh International Auto-injector with filling means
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US9028453B2 (en) 2008-06-19 2015-05-12 Cilag Gmbh International Reusable auto-injector
US9028451B2 (en) 2006-06-01 2015-05-12 Cilag Gmbh International Injection device
US9072833B2 (en) 2006-06-01 2015-07-07 Cilag Gmbh International Injection device
US9180244B2 (en) 2010-04-21 2015-11-10 Abbvie Biotechnology Ltd Wearable automatic injection device for controlled delivery of therapeutic agents
US9265887B2 (en) 2011-01-24 2016-02-23 Abbvie Biotechnology Ltd. Automatic injection devices having overmolded gripping surfaces
US9358346B2 (en) 2005-08-30 2016-06-07 Cilag Gmbh International Needle assembly for a prefilled syringe system
US9649441B2 (en) 2005-04-06 2017-05-16 Cilag Gmbh International Injection device (bayonet cap removal)
US9675758B2 (en) 2004-05-28 2017-06-13 Cilag Gmbh International Injection device
US9675757B2 (en) 2004-05-28 2017-06-13 Cilag Gmbh International Injection device
US9682194B2 (en) 2008-06-19 2017-06-20 Cilag Gmbh International Re-useable auto-injector with filling means
US9682198B2 (en) 2003-08-28 2017-06-20 Becton, Dickinson And Company Intradermal injection device
US9731080B2 (en) 2005-04-06 2017-08-15 Cilag Gmbh International Injection device
US9757520B2 (en) 2006-06-01 2017-09-12 Cilag Gmbh International Injection device
US9770558B2 (en) 2005-09-27 2017-09-26 Cilag Gmbh International Auto-injection device with needle protecting cap having outer and inner sleeves
US9895493B2 (en) 2004-05-28 2018-02-20 Cilag Gmbh International Injection device
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US10799646B2 (en) 2013-06-11 2020-10-13 Cilag Gmbh International Injection device
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US11123492B2 (en) 2013-06-11 2021-09-21 Cilag Gmbh International Injection device
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US6203530B1 (en) 1997-01-28 2001-03-20 Pos-T-Vac, Inc. Auto-injection device
WO1999022792A1 (en) * 1997-11-03 1999-05-14 Ermanno Greco Self-injection device
WO2000024441A1 (en) * 1998-10-26 2000-05-04 Pharmacia Ab Autoinjector
US6270479B1 (en) 1998-10-26 2001-08-07 Pharmacia Ab Autoinjector
US6371939B2 (en) 1998-10-26 2002-04-16 Pharmacia Ab Autoinjector
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WO2001039822A1 (en) * 1999-12-03 2001-06-07 Mattern, Udo Device for injection of antiparasitic agents in pets
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WO2003039634A1 (en) 2001-11-09 2003-05-15 Alza Corporation Pneumatic powered autoinjector
WO2003041770A3 (en) * 2001-11-09 2004-02-26 Alza Corp Collapsible syringe cartridge
US7011649B2 (en) 2001-11-09 2006-03-14 Alza Corporation Collapsible syringe cartridge
WO2003041770A2 (en) * 2001-11-09 2003-05-22 Alza Corporation Collapsible syringe cartridge
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EP2221076A1 (en) 2001-11-09 2010-08-25 Alza Corporation Pneumatic powered autoinjector
US7381201B2 (en) 2002-06-24 2008-06-03 Alza Corporation Reusable, spring driven autoinjector
WO2004067068A1 (en) * 2003-01-24 2004-08-12 Alza Corporation Collapsible syringe cartridge
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ITRM920881A0 (en) 1992-12-11
AU3366293A (en) 1994-07-04
IT1256577B (en) 1995-12-11

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