WO1994019029A1 - A laminated patch tissue repair sheet material - Google Patents
A laminated patch tissue repair sheet material Download PDFInfo
- Publication number
- WO1994019029A1 WO1994019029A1 PCT/US1993/005775 US9305775W WO9419029A1 WO 1994019029 A1 WO1994019029 A1 WO 1994019029A1 US 9305775 W US9305775 W US 9305775W WO 9419029 A1 WO9419029 A1 WO 9419029A1
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- sheet
- tissue repair
- patch tissue
- material according
- mesh
- Prior art date
Links
Classifications
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- A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
- A61L31/04—Macromolecular materials
- A61L31/048—Macromolecular materials obtained by reactions only involving carbon-to-carbon unsaturated bonds
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
- Y10T428/00—Stock material or miscellaneous articles
- Y10T428/249921—Web or sheet containing structurally defined element or component
- Y10T428/249953—Composite having voids in a component [e.g., porous, cellular, etc.]
- Y10T428/249982—With component specified as adhesive or bonding agent
- Y10T428/249985—Composition of adhesive or bonding component specified
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
- Y10T428/00—Stock material or miscellaneous articles
- Y10T428/249921—Web or sheet containing structurally defined element or component
- Y10T428/249953—Composite having voids in a component [e.g., porous, cellular, etc.]
- Y10T428/249987—With nonvoid component of specified composition
- Y10T428/249988—Of about the same composition as, and adjacent to, the void-containing component
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
- Y10T428/00—Stock material or miscellaneous articles
- Y10T428/249921—Web or sheet containing structurally defined element or component
- Y10T428/249953—Composite having voids in a component [e.g., porous, cellular, etc.]
- Y10T428/249987—With nonvoid component of specified composition
- Y10T428/249991—Synthetic resin or natural rubbers
- Y10T428/249992—Linear or thermoplastic
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
- Y10T428/00—Stock material or miscellaneous articles
- Y10T428/31504—Composite [nonstructural laminate]
- Y10T428/3154—Of fluorinated addition polymer from unsaturated monomers
- Y10T428/31544—Addition polymer is perhalogenated
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
- Y10T442/00—Fabric [woven, knitted, or nonwoven textile or cloth, etc.]
- Y10T442/10—Scrim [e.g., open net or mesh, gauze, loose or open weave or knit, etc.]
- Y10T442/102—Woven scrim
- Y10T442/164—Including a preformed film, foil, or sheet
- Y10T442/167—Fluorinated polyolefin film or sheet
Definitions
- This invention relates to the field of implantable sheet materials useful for the repair of living tissue and particularly for hernia repairs.
- Implantable sheet materials for tissue repair are well known. Tissue defects commonly repaired with these materials include wounds of the abdominal wall and in particular hernia repairs. Wounds of the chest wall, diaphragm and other weaknesses of the musculoaponeurotic tissues are also repaired with these materials.
- the first type is a mesh material having a multiplicity of openings through the material, such as Marlex ® Mesh available from C. R. Bard, Inc., Billerica, MA. This is an open mesh knitted from polypropylene monofilament of about 0.17 mm diameter and having openings of about 0.54 mm diameter. These mesh materials offer good suture retention, good mechanical strength, and allow tissue to grow through the mesh openings.
- G0RE-TEX® Soft Tissue Patch made from porous expanded polytetrafluoroethylene, available from W. L. Gore & Associates, Inc., Flagstaff, AZ in 1.0 and 2.0 mm thicknesses. This is a porous sheet material that does not contain large, macroporous holes in the fashion of a mesh. Because there are no large holes for tissue to grow through and around, this material is useful when it is desirable to minimize the risk of tissue adhesion.
- the present invention is a sheet of implantable patch tissue repair material comprising a layer of porous polytetrafluoroethylene sheet material laminated to a layer of mesh-type sheet material having a multiplicity of macroporous openings through the mesh-type sheet material, said openings having a mean minimum diameter of about 0.1 mm.
- the inventive patch tissue repair material offers good strength characteristics, good biocompatibility, suture retention, and flexibility.
- laminated is used herein to describe the bonding together of two layers of material in any fashion that prevents subsequent separation of the layers during ordinary use.
- Macroporous openings are herein considered to be openings visible to the human eye without magnification, and visibly open through the thickness of the layer through which the openings have been formed. Microporous openings require the use of magnification to make them visible to the human eye.
- Figure 1 describes a perspective view of the laminated patch tissue repair sheet material of the present invention.
- Figure 2 describes a cross section of the laminated patch tissue repair sheet material of the present invention.
- Figure 1 shows a perspective view of the laminated patch tissue repair sheet material of the present invention having a layer H of porous PTFE laminated to a layer 13 of mesh-type sheet material having a multiplicity of openings through the mesh-type sheet material.
- Figure 2 describes a cross section of the laminated patch tissue repair sheet material.
- the openings through the mesh-type sheet material should be of at least about 0.1 mm diameter.
- the general shape of the opening is not believed to be of any biological importance and can therefore be round, elliptical, triangular, square, rectangular, hexagonal, etc.
- the term minimum diameter is defined herein as the maximum dimension, measured substantially parallel to the surface of the sheet material, that describes the width or short diameter of the non-circular opening.
- the minimum diameter is to be measured with the sample in a relaxed state with no deforming force.
- the mean minimum diameter is determined by randomly selecting a sample area containing at least 10 macroscopic openings, locating and measuring the minimum diameter of the ten largest openings within that area and calculating the mean diameter of those ten openings. If it is not possible to obtain a sample containing at least ten openings, then all openings within the area of the largest sample obtainable should be included in the calculation of the mean value.
- the layer 3 of the mesh-type sheet material may be any suitable biocompatible material including polypropylene, polyethylene terephthalate, PTFE or microporous PTFE.
- the mesh-type sheet material may be in the form of a sheet from which the openings 15 have been cut or otherwise formed, or alternatively may be an open fabric such as a knit or a weave having a multiplicity of openings formed by widely spaced strands of the fabric.
- the layer H of microporous PTFE is preferably microporous expanded PTFE made according to the teachings of U. S. Patents 3,953,565 and 4,187,390. This material has a icrostructure of nodes interconnected by fibrils. It may also be made according to U.S.
- Patents 4,482,516 and 4,598,011 if a high strength material with a coarse microstructure is desired.
- Layer H may optionally be made as a laminate of multiple layers as taught by U.S. Patents 4,385,093 and 4,478,665.
- Layers H and 13 may be laminated by at least two different methods.
- adhesives may be used to adhere the two layers.
- One such suitable adhesive is Silastic® Medical Adhesive Silicone Type A (Catalog no. 891) from Dow Corning, Midland, MI.
- a thermoplastic adhesive such as Teflon FEP 120 Aqueous Dispersion from E. I. DuPont de Nemours, Wilmington, DE may be used.
- a coating of the FEP dispersion is applied to the side of the mesh-type layer 12 which is intended to be adhered to the porous PTFE layer H.
- the two layers are then adhered by the application of heat and pressure (as for example applied by opposing rollers) with enough heat applied to cause melting of the Teflon FEP 120 Dispersion, about 290°C.
- layers H and 13 may be laminated by the use of heat and pressure without the use of an additional adhesive. This has been found to be the preferred method when the mesh-type layer H of a material having a lower melting point than that of the porous PTFE layer H. For example, when a layer 12 of mesh-type polypropylene is used, it was found that heating the polypropylene layer to about 180°C, which is in excess of the melting point of polypropylene, while simultaneously applying pressure in a direction perpendicular to the planes of layers H and 13 resulted in good adhesion between the two 1ayers.
- both layers H and 13 from porous expanded PTFE sheet materials.
- Layer H was then laminated with the use of heat and pressure to a second layer H of GORE-TEX Soft Tissue Patch material wherein layer H contained no holes. Lamination was accomplished by placing layers H and H between two plates heated to 380T and applying about 1.3 kg/cm 2 pressure to the two layers. The heated plates were allowed to cool to about 300°C while the pressure was maintained.
Abstract
Description
Claims
Priority Applications (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE69329563T DE69329563T2 (en) | 1993-02-18 | 1993-06-16 | MULTILAYER PAVING FILM MATERIAL FOR TISSUE RECOVERY. |
CA002155326A CA2155326C (en) | 1993-02-18 | 1993-06-16 | A laminated patch tissue repair sheet material |
JP6518931A JPH08506750A (en) | 1993-02-18 | 1993-06-16 | Laminated patch tissue repair sheet material |
EP93916573A EP0684844B1 (en) | 1993-02-18 | 1993-06-16 | A laminated patch tissue repair sheet material |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US08/019,394 US5433996A (en) | 1993-02-18 | 1993-02-18 | Laminated patch tissue repair sheet material |
US08/019,394 | 1993-02-18 |
Publications (1)
Publication Number | Publication Date |
---|---|
WO1994019029A1 true WO1994019029A1 (en) | 1994-09-01 |
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Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/US1993/005775 WO1994019029A1 (en) | 1993-02-18 | 1993-06-16 | A laminated patch tissue repair sheet material |
Country Status (6)
Country | Link |
---|---|
US (2) | US5433996A (en) |
EP (1) | EP0684844B1 (en) |
JP (1) | JPH08506750A (en) |
CA (1) | CA2155326C (en) |
DE (1) | DE69329563T2 (en) |
WO (1) | WO1994019029A1 (en) |
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Also Published As
Publication number | Publication date |
---|---|
JPH08506750A (en) | 1996-07-23 |
US5614284A (en) | 1997-03-25 |
US5433996A (en) | 1995-07-18 |
CA2155326C (en) | 1999-08-24 |
EP0684844B1 (en) | 2000-01-05 |
EP0684844A1 (en) | 1995-12-06 |
DE69329563T2 (en) | 2001-03-15 |
CA2155326A1 (en) | 1994-09-01 |
DE69329563D1 (en) | 2000-11-16 |
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