WO1994023034A3 - Variant insulin-like growth factor I receptor subunits and methods for use thereof - Google Patents
Variant insulin-like growth factor I receptor subunits and methods for use thereof Download PDFInfo
- Publication number
- WO1994023034A3 WO1994023034A3 PCT/US1994/003708 US9403708W WO9423034A3 WO 1994023034 A3 WO1994023034 A3 WO 1994023034A3 US 9403708 W US9403708 W US 9403708W WO 9423034 A3 WO9423034 A3 WO 9423034A3
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- receptor subunits
- methods
- growth factor
- variant insulin
- insulin
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
- C07K14/72—Receptors; Cell surface antigens; Cell surface determinants for hormones
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Abstract
Priority Applications (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP6522465A JPH08508409A (en) | 1993-04-06 | 1994-04-05 | Mutant insulin-like growth factor I receptor subunits and methods of using them |
EP94914036A EP0694069A1 (en) | 1993-04-06 | 1994-04-05 | Variant insulin-like growth factor i receptor subunits and methods for use thereof |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US4454093A | 1993-04-06 | 1993-04-06 | |
US08/044,540 | 1993-04-06 |
Publications (2)
Publication Number | Publication Date |
---|---|
WO1994023034A2 WO1994023034A2 (en) | 1994-10-13 |
WO1994023034A3 true WO1994023034A3 (en) | 1994-11-24 |
Family
ID=21932954
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/US1994/003708 WO1994023034A2 (en) | 1993-04-06 | 1994-04-05 | Variant insulin-like growth factor i receptor subunits and methods for use thereof |
Country Status (4)
Country | Link |
---|---|
US (1) | US5942412A (en) |
EP (1) | EP0694069A1 (en) |
JP (1) | JPH08508409A (en) |
WO (1) | WO1994023034A2 (en) |
Families Citing this family (15)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6340674B1 (en) | 1993-03-26 | 2002-01-22 | Thomas Jefferson University | Method of inhibiting the proliferation and causing the differentiation of cells with IGF-1 receptor antisense oligonucleotides |
US6696548B2 (en) * | 1993-12-03 | 2004-02-24 | St. Jude Children's Research Hospital | Antibodies for recognition of alk protein tyrosine/kinase receptor |
AUPM672594A0 (en) * | 1994-07-08 | 1994-08-04 | Royal Children's Hospital Research Foundation | A method for the prophylaxis and/or treatment of proliferative and/or inflammatory skin disorders |
JP2000500654A (en) * | 1995-11-14 | 2000-01-25 | トーマス・ジェファーソン・ユニバーシティ | Induced resistance to tumor growth by soluble IGF-1 receptor |
US6900186B1 (en) | 1999-06-21 | 2005-05-31 | Murdock Children's Research Institute | Method for the prophylaxis and/or treatment of medical disorders |
CA2484000A1 (en) * | 2002-05-24 | 2003-12-04 | Schering Corporation | Neutralizing human anti-igfr antibody |
CA2524305C (en) * | 2003-05-01 | 2015-12-08 | Imclone Systems Incorporated | Fully human antibodies directed against the human insulin-like growth factor-1 receptor |
ATE514783T1 (en) | 2003-11-12 | 2011-07-15 | Schering Corp | PLASMID SYSTEM FOR EXPRESSING MULTIPLE GENES |
AR046639A1 (en) * | 2003-11-21 | 2005-12-14 | Schering Corp | ANTI-IGFR1 ANTIBODY THERAPEUTIC COMBINATIONS |
EP2283831A3 (en) * | 2004-12-03 | 2013-10-23 | Merck Sharp & Dohme Corp. | Biomakers for pre-selection of patients for anti-IGF1R therapy |
WO2006113483A2 (en) * | 2005-04-15 | 2006-10-26 | Schering Corporation | Methods and compositions for treating or preventing cancer |
JP2008546699A (en) * | 2005-06-15 | 2008-12-25 | シェーリング コーポレイション | Anti-IGF1R antibody formulation |
PT2100618E (en) | 2005-06-17 | 2014-04-07 | Philadelphia Health & Educatio | An anti-pdgfralpha antibody for use in the treatment of metastatic bone cancer |
AP2008004569A0 (en) * | 2006-02-03 | 2008-08-31 | Imclone Systems Inc | IGR-IR antagonists as adjuvants for treatment of prostrate cancer |
WO2010146059A2 (en) | 2009-06-16 | 2010-12-23 | F. Hoffmann-La Roche Ag | Biomarkers for igf-1r inhibitor therapy |
-
1994
- 1994-04-05 WO PCT/US1994/003708 patent/WO1994023034A2/en not_active Application Discontinuation
- 1994-04-05 EP EP94914036A patent/EP0694069A1/en not_active Withdrawn
- 1994-04-05 JP JP6522465A patent/JPH08508409A/en active Pending
- 1994-05-26 US US08/249,687 patent/US5942412A/en not_active Expired - Fee Related
Non-Patent Citations (3)
Title |
---|
D. PRAGER ET AL.;: "Human insulin-like growth factor receptor function in pituitary cells is suppressed by a dominant negative mutant", J. CLIN. INVEST., vol. 90, 1992, pages 2117 - 2122 * |
H. YAMASAKI ET AL.;: "Human insulin-like growth factor I receptor 950 tyrosine is required for somatotroph growth factor signal transduction", J. BIOL. CHEM., vol. 267, 1992, pages 20953 - 20958 * |
H. YAMASAKI ET AL.;: "Structure-function of the human insulin-like growth factor-I receptor: a discordance of somatotroph internalization and signaling", MOL. ENDOCRINOL., vol. 7, 1993, pages 681 - 685 * |
Also Published As
Publication number | Publication date |
---|---|
WO1994023034A2 (en) | 1994-10-13 |
US5942412A (en) | 1999-08-24 |
EP0694069A1 (en) | 1996-01-31 |
JPH08508409A (en) | 1996-09-10 |
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