WO1994026105A1 - A method for controlling a pest population - Google Patents

A method for controlling a pest population Download PDF

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Publication number
WO1994026105A1
WO1994026105A1 PCT/FI1994/000187 FI9400187W WO9426105A1 WO 1994026105 A1 WO1994026105 A1 WO 1994026105A1 FI 9400187 W FI9400187 W FI 9400187W WO 9426105 A1 WO9426105 A1 WO 9426105A1
Authority
WO
WIPO (PCT)
Prior art keywords
antiestrogen
population
baits
pest
progestin
Prior art date
Application number
PCT/FI1994/000187
Other languages
French (fr)
Inventor
Lauri Kangas
Kalevi Heiskanen
Original Assignee
Orion-Yhtymä Oy
SALMINEN, Hannu, J.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Orion-Yhtymä Oy, SALMINEN, Hannu, J. filed Critical Orion-Yhtymä Oy
Priority to AU66513/94A priority Critical patent/AU6651394A/en
Priority to US08/549,780 priority patent/US5672628A/en
Priority to EP94915163A priority patent/EP0697810A1/en
Publication of WO1994026105A1 publication Critical patent/WO1994026105A1/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N25/00—Biocides, pest repellants or attractants, or plant growth regulators, characterised by their forms, or by their non-active ingredients or by their methods of application, e.g. seed treatment or sequential application; Substances for reducing the noxious effect of the active ingredients to organisms other than pests
    • A01N25/002—Biocides, pest repellants or attractants, or plant growth regulators, characterised by their forms, or by their non-active ingredients or by their methods of application, e.g. seed treatment or sequential application; Substances for reducing the noxious effect of the active ingredients to organisms other than pests containing a foodstuff as carrier or diluent, i.e. baits
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N25/00—Biocides, pest repellants or attractants, or plant growth regulators, characterised by their forms, or by their non-active ingredients or by their methods of application, e.g. seed treatment or sequential application; Substances for reducing the noxious effect of the active ingredients to organisms other than pests
    • A01N25/002—Biocides, pest repellants or attractants, or plant growth regulators, characterised by their forms, or by their non-active ingredients or by their methods of application, e.g. seed treatment or sequential application; Substances for reducing the noxious effect of the active ingredients to organisms other than pests containing a foodstuff as carrier or diluent, i.e. baits
    • A01N25/004—Biocides, pest repellants or attractants, or plant growth regulators, characterised by their forms, or by their non-active ingredients or by their methods of application, e.g. seed treatment or sequential application; Substances for reducing the noxious effect of the active ingredients to organisms other than pests containing a foodstuff as carrier or diluent, i.e. baits rodenticidal
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N33/00—Biocides, pest repellants or attractants, or plant growth regulators containing organic nitrogen compounds
    • A01N33/02—Amines; Quaternary ammonium compounds
    • A01N33/08—Amines; Quaternary ammonium compounds containing oxygen or sulfur
    • A01N33/10—Amines; Quaternary ammonium compounds containing oxygen or sulfur having at least one oxygen or sulfur atom directly attached to an aromatic ring system
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N45/00—Biocides, pest repellants or attractants, or plant growth regulators, containing compounds having three or more carbocyclic rings condensed among themselves, at least one ring not being a six-membered ring

Definitions

  • the invention relates to the control of pest population, in particular harmful rodent and bird populations, by using baits having hormonal action.
  • Pests such as rats when present in large numbers, cause great economic and hygienic harm in different parts of the world by spoiling grain and foodstuffs or by transmitting diseases to people and animals. Attempts have previously been made to control pest populations by using, for example, traps and poison baits.
  • Pests for which the method according to the invention is suitable include in particular rodents such as rat, hare and rabbit, and birds such as crow, pigeon, sparrow and gull.
  • the active substances according to the invention are orally active antiestrogens and progestins.
  • the orally active antiestrogen according to the invention is preferably a non-steroidal antiestrogen.
  • non-steroidal antiestrogens having a triphenylethylene structure. Examples of these compounds are tamoxifen, 4-hydroxytamoxifen, 3-hydroxytamoxifen, toremifene, N-demethyltoremifene, 4-hydroxytoremifene and clomiphene.
  • progestins progesterone can in particular be mentioned.
  • an antiestrogen very effectively prevents the embedding of the ovum.
  • an antiestrogen reduces the reproductive capacity of rodents.
  • Bird populations can be controlled effectively with a progestin, which prevents fertilization and thereby the development of eggs into young ones.
  • progestin prevents the reproduction of rodents, and so progestin and antiestrogen can be used either alternatively or together for rodent population control .
  • the invention includes a method for controlling a pest population comprising administering an antiestrogen or a progestin to pests in an amount which controls their reproduction.
  • a method for controlling a pest population in a geographical area comprising distributing a composition containing an orally active antiestrogen or progestin mixed with an edible carrier in the area.
  • the invention also includes new bait compositions useful for controlling a pest population.
  • the baits according to the invention comprise an antiestrogen or a progestin mixed with an edible carrier such baits being palatable to the pest.
  • the edible carrier means here any non-toxic substance palatable to the pest.
  • the edible carrier may be, for example, a foodstuff or a feed.
  • Especially suitable carriers include grain products, pieces of bread, flours, oils such as vegetable oils or fish oils, sugar, and various mixtures of these.
  • the active substance and the edible carrier are mixed using known methods and the resulting bait compositions are distributed in the pest-infested area.
  • the active substance according to the invention is preferably dissolved in a food oil before being mixed with the carrier.
  • Preferred baits for rats are cakes made of wheat flour, water and food oil, the active substance being dissolved in the food oil.
  • the bait cakes are preferably moistened with codliver oil to improve their palatability.
  • the finished baits are distributed in the pest-infested area, preferably daily throughout the reproductive period of the pest.
  • the baiting period preferably last at least one natural life span of the pest.
  • the baiting period is typically 1-2 years.
  • a suitable amount of the active substance in a bait is about 0.02 - 1.0 mg, preferably about 0.1 - 0.5 mg, per one gram of dry bait. In a rat, a dose of about 0.5 mg of the active substance suffices to inhibit the reproduction of the female. No aversion to such baits by rats has been observed.
  • Baits can also be distributed in a pest-infested area in specific bait houses, from which the pest animals learn to come to fetch hormone baits. Bait houses can be used both at waste dumps and in population centers. Thus the baits will remain dry and the individuals in the pest population will find hormone-containing baits daily. For birds such bird houses are needed only just before the mating season.
  • Progesterone or tamoxifen nitrate was mixed with chicken feed at 200 mg per 2 kg of the feed. In chickens which had received tamoxifen, 26 out of 32 eggs were fertilized. In the chickens which received progesterone, only 4 out of 35 eggs were fertilized. The experiment shows that progesterone baits inhibit effectively the reproduction of a bird population, whereas tamoxifen baits are less effective.

Abstract

A population of pests, especially a population of rodents or birds, can be controlled hormonally by means of baits which contain an orally active antiestrogen or progestin. The hormone present in the baits weakens the reproductive capacity of the pests and thereby controls their population.

Description

A METHOD FOR CONTROLLING A PEST POPULATION
The invention relates to the control of pest population, in particular harmful rodent and bird populations, by using baits having hormonal action.
Pests such as rats, when present in large numbers, cause great economic and hygienic harm in different parts of the world by spoiling grain and foodstuffs or by transmitting diseases to people and animals. Attempts have previously been made to control pest populations by using, for example, traps and poison baits.
It has now been discovered that when baits containing an antiestrogen or a progestin as an active substance are distributed in a pest-infested area during the reproduction period of the pests, the numbers of young and newborn individuals decrease rapidly. The hormonal baits according to the invention are not lethal to the pests; the baits reduce the reproductive capacity of the pests and thus control their population. The active substances accord¬ ing to the invention are more nature-friendly than are the poisons commonly used for pest control, and they have not been noted to change the normal behaviour of the pests. Furthermore the pests do not have any aversion to baits of the invention.
Pests for which the method according to the invention is suitable include in particular rodents such as rat, hare and rabbit, and birds such as crow, pigeon, sparrow and gull.
The active substances according to the invention are orally active antiestrogens and progestins. The orally active antiestrogen according to the invention is preferably a non-steroidal antiestrogen. Especially suitable are non-steroidal antiestrogens having a triphenylethylene structure. Examples of these compounds are tamoxifen, 4-hydroxytamoxifen, 3-hydroxytamoxifen, toremifene, N-demethyltoremifene, 4-hydroxytoremifene and clomiphene. Of progestins, progesterone can in particular be mentioned.
It has been observed that in a rodent, such as a rat, an antiestrogen very effectively prevents the embedding of the ovum. Thus an antiestrogen reduces the reproductive capacity of rodents. Bird populations can be controlled effectively with a progestin, which prevents fertilization and thereby the development of eggs into young ones. It has also been observed that progestin prevents the reproduction of rodents, and so progestin and antiestrogen can be used either alternatively or together for rodent population control .
The invention includes a method for controlling a pest population comprising administering an antiestrogen or a progestin to pests in an amount which controls their reproduction. Especially the invention includes a method for controlling a pest population in a geographical area comprising distributing a composition containing an orally active antiestrogen or progestin mixed with an edible carrier in the area. The invention also includes new bait compositions useful for controlling a pest population.
The baits according to the invention comprise an antiestrogen or a progestin mixed with an edible carrier such baits being palatable to the pest. The edible carrier means here any non-toxic substance palatable to the pest. The edible carrier may be, for example, a foodstuff or a feed. Especially suitable carriers include grain products, pieces of bread, flours, oils such as vegetable oils or fish oils, sugar, and various mixtures of these. The active substance and the edible carrier are mixed using known methods and the resulting bait compositions are distributed in the pest-infested area. The active substance according to the invention is preferably dissolved in a food oil before being mixed with the carrier. Preferred baits for rats are cakes made of wheat flour, water and food oil, the active substance being dissolved in the food oil. The bait cakes are preferably moistened with codliver oil to improve their palatability. The finished baits are distributed in the pest-infested area, preferably daily throughout the reproductive period of the pest. The baiting period preferably last at least one natural life span of the pest. For rats the baiting period is typically 1-2 years. A suitable amount of the active substance in a bait is about 0.02 - 1.0 mg, preferably about 0.1 - 0.5 mg, per one gram of dry bait. In a rat, a dose of about 0.5 mg of the active substance suffices to inhibit the reproduction of the female. No aversion to such baits by rats has been observed. When the baits according to the invention are distributed in the rat-infested area, such as dumps, in amount of about 350 baits/day each bait containing about 0.5 mg antiestrogen, the number of young rats decrease effectively in about 2 months. Baits can also be distributed in a pest-infested area in specific bait houses, from which the pest animals learn to come to fetch hormone baits. Bait houses can be used both at waste dumps and in population centers. Thus the baits will remain dry and the individuals in the pest population will find hormone-containing baits daily. For birds such bird houses are needed only just before the mating season.
The invention is further illustrated by the following Examples.
Example 1.
From wheat flour, water and food oil, cakes weighing approx. 2 g and containing tamoxifen citrate about 0.5 mg were prepared. The tamoxifen citrate was dissolved in the food oil used. Finished baits were placed at a dump, the rat population of which was counted before the beginning of the experiment and several times during the experiment. Special attention was paid to the number of small (young and newborn) rats. Corresponding but hormone-free baits were placed at another dump, and counting was done as above. Baits were distributed for 2 months at a rate of approx. 350 baits/day at each dump. In the rat population which was administered the hormone, young rats disappeared almost entirely within 2 months, whereas the rats which had received hormone-free baits reproduced strongly and the number of small rats increased. The experiment shows that by using antiestrogen baits a rodent population can be controlled effectively in its natural environment.
Example 2.
Progesterone or tamoxifen nitrate was mixed with chicken feed at 200 mg per 2 kg of the feed. In chickens which had received tamoxifen, 26 out of 32 eggs were fertilized. In the chickens which received progesterone, only 4 out of 35 eggs were fertilized. The experiment shows that progesterone baits inhibit effectively the reproduction of a bird population, whereas tamoxifen baits are less effective.

Claims

Claims
1. A method for controlling a pest population in a geographical area comprising distributing a composition containing an orally active antiestrogen or progestin mixed with an edible carrier in the area in an amount which controls their reproduction.
2. A method according to Claim 1 wherein the orally active antiestrogen is a non-steroidal antiestrogen having a triphenylethylene structure.
3. A method according to Claim 1 or 2 wherein the antiestrogen is tamoxifen, 4-hydroxytamoxifen, 3-hydroxytamoxifen, toremifene, N- demethyltoremifene, 4-hydroxytoremifene or clomiphene.
4. A method according to any of claims 1 -3 wherein the pest is a rodent or a bird.
5. The use of an antiestrogen for the control of a pest population, especially a rodent population.
6. The use of an progestin for the control of a pest population, especially a bird population.
7. A composition for controlling a pest population comprising an orally active antiestrogen or progestin mixed with an edible carrier such composition being palatable to the pests.
8. A composition according to Claim 7 wherein the antiestrogen or progestin is present in amounts of about 0.02 - 1.0 mg, preferably about 0.1 - 0.5 mg, per one gram of dry bait.
PCT/FI1994/000187 1993-05-14 1994-05-11 A method for controlling a pest population WO1994026105A1 (en)

Priority Applications (3)

Application Number Priority Date Filing Date Title
AU66513/94A AU6651394A (en) 1993-05-14 1994-05-11 A method for controlling a pest population
US08/549,780 US5672628A (en) 1993-05-14 1994-05-11 Method for controlling a pest population
EP94915163A EP0697810A1 (en) 1993-05-14 1994-05-11 A method for controlling a pest population

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FI932220 1993-05-14
FI932220A FI96265C (en) 1993-05-14 1993-05-14 Restriction of a population of pests with hormonally acting bait

Publications (1)

Publication Number Publication Date
WO1994026105A1 true WO1994026105A1 (en) 1994-11-24

Family

ID=8537941

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/FI1994/000187 WO1994026105A1 (en) 1993-05-14 1994-05-11 A method for controlling a pest population

Country Status (5)

Country Link
US (1) US5672628A (en)
EP (1) EP0697810A1 (en)
AU (1) AU6651394A (en)
FI (1) FI96265C (en)
WO (1) WO1994026105A1 (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6326392B1 (en) 1997-11-06 2001-12-04 American Home Products Corporation Anti-estrogen plus progestin containing oral contraceptives

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MX2018014382A (en) 2016-05-23 2019-08-12 Gries Gerhard Compositions and methods comprising pheromone compounds androstenone, testosterone, progesterone and estrogen.

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US3293263A (en) * 1963-12-09 1966-12-20 Upjohn Co Diphenylbenzocycloalkenes
US3419661A (en) * 1964-01-13 1968-12-31 Univ Missouri Oral contraceptive for birds
FR1565334A (en) * 1966-09-30 1969-05-02
EP0347227A1 (en) * 1988-06-17 1989-12-20 E.I. Du Pont De Nemours And Company Pesticidal compositions
FR2641943A1 (en) * 1989-01-25 1990-07-27 Rouquet Colette Product for controlling rats and other vertebrate pests
WO1993007749A1 (en) * 1991-10-23 1993-04-29 Akzo Nobel N.V. Pest control compositions

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US3480679A (en) * 1963-12-09 1969-11-25 Upjohn Co 1,2 - diphenyl - 1,2,3,4 - tetrahydro - 1-naphthols and 1,2 - diphenyl - 1-hydroxyindanes

Patent Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3293263A (en) * 1963-12-09 1966-12-20 Upjohn Co Diphenylbenzocycloalkenes
US3419661A (en) * 1964-01-13 1968-12-31 Univ Missouri Oral contraceptive for birds
FR1565334A (en) * 1966-09-30 1969-05-02
EP0347227A1 (en) * 1988-06-17 1989-12-20 E.I. Du Pont De Nemours And Company Pesticidal compositions
FR2641943A1 (en) * 1989-01-25 1990-07-27 Rouquet Colette Product for controlling rats and other vertebrate pests
WO1993007749A1 (en) * 1991-10-23 1993-04-29 Akzo Nobel N.V. Pest control compositions

Non-Patent Citations (7)

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Title
ASTM SPEC.TECH.PUBL., STP 625, TEST METHODS VERTEBR. PEST CONTROL MANAGE. MATER., SYMP., 1977, pages 99 - 105 *
CHEMICAL ABSTRACTS, vol. 101, no. 13, 24 September 1984, Columbus, Ohio, US; abstract no. 105776, E.A.ELIAS ET AL.: "Fertility of female mice fed coumestrol and diethylstilbestrol" *
CHEMICAL ABSTRACTS, vol. 87, no. 15, 10 October 1977, Columbus, Ohio, US; abstract no. 113094, M.E.GODFREY: "Techniques for the evaluation of potential rabbit (Oryctolagus cuniculus) chemosterilants" *
G.BHAT ET AL.: "Effect of Clomiphene Citrate on Ovarian and Oviducal Activities in an Avian Pest, the Yellow-Throated Sparrow (Petronia xanthocollis)", ZOOLOGISCHE JAHRBÜCHER, vol. 94, no. 3, 1990, JENA, DE, pages 371 - 374 *
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M.VERDERAME: "CRC Handbook of Hormones, Vitamines, and Radiopaques", 1989, CRC PRESS, BOCA RATON, FLORIDA, US *
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Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6326392B1 (en) 1997-11-06 2001-12-04 American Home Products Corporation Anti-estrogen plus progestin containing oral contraceptives

Also Published As

Publication number Publication date
EP0697810A1 (en) 1996-02-28
US5672628A (en) 1997-09-30
FI96265C (en) 1996-06-10
FI932220A (en) 1994-11-15
FI932220A0 (en) 1993-05-14
AU6651394A (en) 1994-12-12
FI96265B (en) 1996-02-29

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