WO1995003071A1 - Method for sterilizing products - Google Patents
Method for sterilizing products Download PDFInfo
- Publication number
- WO1995003071A1 WO1995003071A1 PCT/CA1994/000401 CA9400401W WO9503071A1 WO 1995003071 A1 WO1995003071 A1 WO 1995003071A1 CA 9400401 W CA9400401 W CA 9400401W WO 9503071 A1 WO9503071 A1 WO 9503071A1
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- product
- blood
- irradiation
- kgy
- cells
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2/00—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2/00—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor
- A61L2/0005—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor for pharmaceuticals, biologicals or living parts
- A61L2/0011—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor for pharmaceuticals, biologicals or living parts using physical methods
- A61L2/0029—Radiation
- A61L2/0035—Gamma radiation
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2/00—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor
- A61L2/0005—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor for pharmaceuticals, biologicals or living parts
- A61L2/0011—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor for pharmaceuticals, biologicals or living parts using physical methods
- A61L2/0029—Radiation
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2/00—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor
- A61L2/0005—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor for pharmaceuticals, biologicals or living parts
- A61L2/0011—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor for pharmaceuticals, biologicals or living parts using physical methods
- A61L2/0029—Radiation
- A61L2/0076—Radiation using a photocatalyst or photosensitiser
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2202/00—Aspects relating to methods or apparatus for disinfecting or sterilising materials or objects
- A61L2202/20—Targets to be treated
- A61L2202/22—Blood or products thereof
Definitions
- the present invention relates to a method for sterilizing products to remove biological contaminants such as viruses, bacteria, yeasts, molds, mycroplasmas and parasites.
- the present invention provides a method for sterilizing a product comprising: a) providing a product to be sterilized in a form having a solid content of less than 20% by weight; and b) irradiating the product for a period of time of not less than 10 hours at a rate sufficient to provide a total dose of irradiation of between about 20 to about 32 kGy.
- the gamma radiation is delivered over an extended period of time which substantially reduces the damage to the product.
- the irradiation is carried out for a period of time of not less than 10 hours, preferably from about 20 to about 40 hours, more preferably from about 20 to about 30 hours.
- the rate of irradiation is in the range of from about 0.5 kGy/hr to about 3.0 kGy/hr, depending on the product to be sterilized as well as the length of the irradiation time.
- the total amount of irradiation given is typically in the range of from about 20 to about 32 kGy as these levels have been shown to be effective in destroying contaminants such as viruses.
- the product is irradiated in a form containing preferably less than 20% solids. Consequently, certain products must be diluted before irradiation. Treating products in diluted form also serves to reduce degradation of the product during irradiation.
- the choice of diluent depends on the nature of the product to be irradiated. For example, when irradiating blood cells one would choose a physiologically acceptable diluent such as citrate phosphate dextrose.
- the process according to the present invention can be carried out at ambient temperature and does not require the cooling, freezing or chemical treatment of the product before the process is carried out. This avoids some of the extra treatment steps that are present in prior art processes.
- the method of the present invention is useful in treating organic products that are sensitive to irradiation. Such products may be prone to degradation when irradiated by standard methods. However, irradiating sensitive products by the present method would not be expected to be harmful to the products.
- the method is typically applied to biological products such as blood ai.d blood components although it is not limited thereto.
- a scavenger may be added to bind free radicals arid other materials that are toxic to cells.
- a suitable scavenger is ethanol.
- the cells were irradiated in a commercial size gamma irradiator which contained a cobalt 60 source rack. Irradiation was done off carrier in an unprotected box. The cells were irradiated for twenty four hours at a rate of approximately 1 kGy/hr. After the irradiation period the red blood cells were examined visually and were found to be viable, having a brilliant red colour. A control sample, consisting of packed red blood cells that were not diluted with the above-described CPD solution, was not viable after irradiation.
- the control sample consisted of blood from the same bag as the test sample but it did not undergo irradiation.
- Table 1 illustrates that dilution and irradiation of human blood cells did not significantly alter the white blood cell count.
- the platelet count a hematocrit values were slightly lower than the control, however these values are still within the range that is seen in normal adult blood.
- the level of haemoglobin was higher than in the control indicating that some red blood cells did lyse during the procedure. This also evidenced by the lower red blood cell count. Nevertheless, contrary to what has been previously published, up to 25 kGy of radiation did not destroy the components of blood by the present procedure.
- the cells were also counted and found to be viable after 25 kGy of gamma irradiation.
- Dextrose (or glucose) containing solutions are used in the treatment of carbohydrate and fluid depletion, in the treatment of hypoglycae ia, as a plasma expander, in renal dialysis and to counteract hepatotoxins (4,5). Dextrose is also the preferred source of carbohydrate in parental nutrition regimens (4,5).
- the dextrose must be sterilized before use. Sterilization of dextrose containing products is generally done by heat sterilization or autoclaving. Unfortunately, these methods have been reported to degrade or caramelize dextrose containing solutions resulting in a color change in the solution (5) . Gamma irradiation of glucose has also been reported to decompose glucose containing solutions (6) . Therefore, there is a need for a method that can sterilize dextrose containing products that does not degrade the product itself. In view of the problems of the prior art, a dextrose solution was treated according to the method of the present invention as follows.
- a 5% dextrose solution was irradiated for 24 hours, at a rate of approximately 1 kGy/hr. After irradiation the product was tested and it was found that there was no visible light spectrum change as compared to the non-irradiated control. Therefore, the present method can be useful in sterilizing products that contain dextrose.
- Normal Human Serum Albumin was irradiated as the 25% salt solution to a total dose of 25 kGy over 36 hours using a Gamma cell 220.
- the temperature was not controlled during the irradiation but it is estimated that the container holding the albumin solution was approximately 23°C.
- the results of HPLC analysis are given in Table 2.
- Normal Human Serum Albumin can safely be irradiated to 25 kGy at room temperature without adversely affecting the essential properties of the protein. This has not been demonstrated before. All other attempts at irradiating serum albumin require that it be irradiated in the frozen stage. This adds to the cost and difficulty of doing the irradiation.
- the cells were gently agitated after 12, 16 and 24 hou ⁇ s. Further, in the third experiment, (Example 7) , the cells were placed in T25 flasks to provide greater surface area and reduce the concentration due to settling in the bottom of the centrifuge tubes.
- red blood cells (RBCs) 1.
- a "mock" infection was performed, by adding a small amount of non-infectious laboratory buffer, phosphate buffered saline (PBS) .
- PBS phosphate buffered saline
- Four infected and four non-infected tubes were subjected to the process.
- the remaining 8 tubes were handled in an identical manner, except that they were not subjected to the process.
- MCs mononuclear cells
- MCs mononuclear cells
- penicillin, streptomycin, glutamine, HEPES buffer 10% fetal calf serum and other additives (penicillin, streptomycin, glutamine, HEPES buffer) along with 1 ug/ml PHA-P.
- the cells were resuspended in fresh medium with rIL-2 (20 U/ml) .
- the cultures were maintained for 7 days. Twice weekly, a portion of the culture medium was harvested for the measurement of HIV p24 antigen levels (commercial ELISA kit. Coulter Electronics, Hialeah, FL) for the measurement of viral growth.
- HIV p24 antigen value was > 30 pg/ml.
- the viral titer was calculated according to the Spearman-Karber method (see
- M titer (in log 4) xk: dose of highest dilution d: space between dilutions n: number of wells per dilution r: sum of total number of wells
- Table 4 The abbreviations used in Table 4 are explained under Table 3. As described above, HIV cultures were established using 0.5 ml aliquots of unprocessed and processed study samples. P24 antigen levels (pg/ml) from the study samples on day 4 and day 7 of culture are shown in Table 5. Table 5
- red blood cells were minimally affected by the process, although some reproducible macrocytosis was observed. Although on co-culturing of processed samples, there appeared to be some residual live virus, this was not confirmed by direct titration experiments.
- Red blood cell parameters for the baseline sample as well as for the unprocessed and processed study samples are shown in Table 7.
- the abbreviations used in Table 7 are defined in Table 3.
- the method can be used to treat an extremely wide variety of products that require sterilization.
- the fact that the method has proven effective in blood which is a fragile biological material makes it reasonable to predict that the method can be used on many similarly sensitive products.
- examples of other products that may be treated include pharmaceuticals, proteins, nucleic acids, blood components, body fluids (such as cerebral spinal fluid, saliva) , liposomes, glucose containing products, cell cultures, fetal bovine serum, bone marrow, organs, foods and cosmetics such as shampoos, lotions and creams.
Abstract
Description
Claims
Priority Applications (18)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DK94922207T DK0710124T3 (en) | 1993-07-22 | 1994-07-22 | Method of sterilizing products |
AT94922207T ATE235262T1 (en) | 1993-07-22 | 1994-07-22 | METHOD FOR STERILIZING PRODUCTS |
AU73434/94A AU687425B2 (en) | 1993-07-22 | 1994-07-22 | Method for sterilizing products |
BR9407138A BR9407138A (en) | 1993-07-22 | 1994-07-22 | Method for sterilizing products |
EP94922207A EP0710124B1 (en) | 1993-07-22 | 1994-07-22 | Method for sterilizing products |
DE69432351T DE69432351T2 (en) | 1993-07-22 | 1994-07-22 | METHOD FOR STERILIZING PRODUCTS |
CA002167528A CA2167528C (en) | 1993-07-22 | 1994-07-22 | Method for sterilizing products |
JP7504833A JPH09500553A (en) | 1993-07-22 | 1994-07-22 | Product sterilization method |
NZ269786A NZ269786A (en) | 1993-07-22 | 1994-07-22 | Sterilising a product by irradiation with gamma rays for at least 10 hours |
US08/573,149 US6171549B1 (en) | 1993-07-22 | 1995-12-15 | Method for sterilizing products |
FI960281A FI960281A (en) | 1993-07-22 | 1996-01-19 | Procedure for sterilizing products |
US09/570,929 US6346216B1 (en) | 1993-07-22 | 2000-05-15 | Method for sterilizing products |
US09/985,606 US6635222B2 (en) | 1993-07-22 | 2001-11-05 | Method of sterilizing products |
US10/341,355 US20030143107A1 (en) | 1993-07-22 | 2003-01-14 | Method for sterilizing products |
US10/457,451 US20040067157A1 (en) | 1993-07-22 | 2003-06-10 | Methods for sterilizing biological materials |
US10/694,734 US20040101437A1 (en) | 1993-07-22 | 2003-10-29 | Methods for sterilizing biological materials |
US10/694,733 US20040101436A1 (en) | 1993-07-22 | 2003-10-29 | Methods for sterilizing biological materials |
US11/843,165 US20080176306A1 (en) | 1993-07-22 | 2007-08-22 | Methods for Sterilizing Biological Materials |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US095,698 | 1993-07-22 | ||
US08/095,698 US5362442A (en) | 1993-07-22 | 1993-07-22 | Method for sterilizing products with gamma radiation |
Related Parent Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
US08/095,698 Continuation-In-Part US5362442A (en) | 1993-07-22 | 1993-07-22 | Method for sterilizing products with gamma radiation |
Related Child Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
US08/573,149 Continuation-In-Part US6171549B1 (en) | 1993-07-22 | 1995-12-15 | Method for sterilizing products |
Publications (1)
Publication Number | Publication Date |
---|---|
WO1995003071A1 true WO1995003071A1 (en) | 1995-02-02 |
Family
ID=22253204
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/CA1994/000401 WO1995003071A1 (en) | 1993-07-22 | 1994-07-22 | Method for sterilizing products |
Country Status (15)
Country | Link |
---|---|
US (6) | US5362442A (en) |
EP (1) | EP0710124B1 (en) |
JP (1) | JPH09500553A (en) |
KR (1) | KR100389846B1 (en) |
AT (1) | ATE235262T1 (en) |
AU (1) | AU687425B2 (en) |
BR (1) | BR9407138A (en) |
CA (1) | CA2167528C (en) |
DE (1) | DE69432351T2 (en) |
DK (1) | DK0710124T3 (en) |
ES (1) | ES2197907T3 (en) |
FI (1) | FI960281A (en) |
NZ (1) | NZ269786A (en) |
PT (1) | PT710124E (en) |
WO (1) | WO1995003071A1 (en) |
Cited By (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE19543503A1 (en) * | 1995-11-22 | 1997-05-28 | Nukem Gmbh | Exposing fluid to intense radiation |
US6635222B2 (en) | 1993-07-22 | 2003-10-21 | Clearant, Inc. | Method of sterilizing products |
WO2003103390A1 (en) * | 2002-06-07 | 2003-12-18 | Promethean Lifesciences, Inc. | Sterilization, stabilization and preservation of functional biologics |
US6682695B2 (en) | 2001-03-23 | 2004-01-27 | Clearant, Inc. | Methods for sterilizing biological materials by multiple rates |
US6696060B2 (en) | 2001-06-14 | 2004-02-24 | Clearant, Inc. | Methods for sterilizing preparations of monoclonal immunoglobulins |
US6783968B2 (en) | 2001-09-24 | 2004-08-31 | Clearant, Inc. | Methods for sterilizing preparations of glycosidases |
US7252799B2 (en) | 2001-08-31 | 2007-08-07 | Clearant, Inc. | Methods for sterilizing preparations containing albumin |
US8580192B2 (en) | 2006-10-31 | 2013-11-12 | Ethicon, Inc. | Sterilization of polymeric materials |
Families Citing this family (150)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20040067157A1 (en) * | 1993-07-22 | 2004-04-08 | Clearant, Inc. | Methods for sterilizing biological materials |
US6156337A (en) * | 1994-07-08 | 2000-12-05 | Opperbas Holding B.V. | Method for high loading of vesicles with biopolymeric substances |
US6770278B1 (en) * | 1994-12-02 | 2004-08-03 | Central Biomedia, Inc. | Methods of making and using immunoglobulin (Ig) compositions |
US5548066A (en) * | 1994-12-02 | 1996-08-20 | Central Biomedia, Inc. | Failure of passive transfer immune serum and method of making same |
US6403124B1 (en) | 1997-04-16 | 2002-06-11 | Sigma-Tau Industrie Farmaceutiche Riunite S.P.A. | Storage and maintenance of blood products including red blood cells and platelets |
US6482585B2 (en) * | 1997-04-16 | 2002-11-19 | Sigma-Tau Industrie Farmaceutiche Riunite S.P.A. | Storage and maintenance of blood products including red blood cells and platelets |
US6637438B1 (en) | 1997-04-21 | 2003-10-28 | Kerry Scott Lane | Method for assay and removal of harmful toxins during processing of tobacco products |
US6058940A (en) * | 1997-04-21 | 2000-05-09 | Lane; Kerry Scott | Method and system for assay and removal of harmful toxins during processing of tobacco products |
US6036924A (en) | 1997-12-04 | 2000-03-14 | Hewlett-Packard Company | Cassette of lancet cartridges for sampling blood |
US6391005B1 (en) | 1998-03-30 | 2002-05-21 | Agilent Technologies, Inc. | Apparatus and method for penetration with shaft having a sensor for sensing penetration depth |
US6187000B1 (en) * | 1998-08-20 | 2001-02-13 | Endius Incorporated | Cannula for receiving surgical instruments |
US20090297602A1 (en) * | 1998-11-02 | 2009-12-03 | Devane John G | Modified Release Loxoprofen Compositions |
NZ511442A (en) * | 1998-11-02 | 2003-02-28 | Elan Corp Plc | Multiparticulate modified release composition for multiple dosing of ADD patients with methylphenidate HCl |
US6524528B1 (en) * | 1999-03-02 | 2003-02-25 | Suzanne C. Gottuso | Method of sterilizing a tattooing solution through irradiation |
US6713773B1 (en) | 1999-10-07 | 2004-03-30 | Mitec, Inc. | Irradiation system and method |
US6429608B1 (en) | 2000-02-18 | 2002-08-06 | Mitec Incorporated | Direct injection accelerator method and system |
AU2001245338A1 (en) | 2000-02-24 | 2001-09-03 | Brian T. Dalziel | Bulk material irradiation system and method |
US6707049B1 (en) | 2000-03-21 | 2004-03-16 | Mitec Incorporated | Irradiation system with compact shield |
US20040086420A1 (en) * | 2000-03-23 | 2004-05-06 | Macphee Martin J. | Methods for sterilizing serum or plasma |
US20030012687A1 (en) * | 2000-03-23 | 2003-01-16 | Macphee Martin J. | Methods of sterilizing biological materials |
AU2001259031B2 (en) * | 2000-03-23 | 2006-04-13 | Clearant, Inc. | Methods for sterilizing biological materials |
AU2001263200A1 (en) * | 2000-05-17 | 2001-11-26 | The American National Red Cross | Gamma irradiation of protein-based pharmaceutical products |
US20020098182A1 (en) * | 2000-09-28 | 2002-07-25 | Richard Weisbart | Treatment of immune-mediated diseases by oral administration of plasma fractions enriched in immunoglobulin G |
EP1379127B1 (en) * | 2000-09-28 | 2013-04-17 | Nanocyte Inc. | Methods, compositions and devices utilizing stinging cells/capsules for delivering a therapeutic or a cosmetic agent into a tissue |
US7632522B2 (en) | 2000-09-28 | 2009-12-15 | Nanocyte Inc. | Use of stinging cells/capsules for the delivery of active agents to keratinous substances |
US20070281037A9 (en) * | 2000-09-28 | 2007-12-06 | Nanocyte Inc. | Sterile preparations and compositions including stinging capsules and methods of producing and using same |
US8641644B2 (en) | 2000-11-21 | 2014-02-04 | Sanofi-Aventis Deutschland Gmbh | Blood testing apparatus having a rotatable cartridge with multiple lancing elements and testing means |
US7381976B2 (en) | 2001-03-13 | 2008-06-03 | Triton Thalassic Technologies, Inc. | Monochromatic fluid treatment systems |
US7154103B2 (en) * | 2001-04-02 | 2006-12-26 | Mitec Incorporated | Method of providing extended shelf life fresh meat products |
CA2443150A1 (en) * | 2001-04-02 | 2002-10-10 | Mitec Incorporated | Irradiation system and method |
US7981056B2 (en) | 2002-04-19 | 2011-07-19 | Pelikan Technologies, Inc. | Methods and apparatus for lancet actuation |
US9226699B2 (en) | 2002-04-19 | 2016-01-05 | Sanofi-Aventis Deutschland Gmbh | Body fluid sampling module with a continuous compression tissue interface surface |
US7699791B2 (en) | 2001-06-12 | 2010-04-20 | Pelikan Technologies, Inc. | Method and apparatus for improving success rate of blood yield from a fingerstick |
US7344507B2 (en) | 2002-04-19 | 2008-03-18 | Pelikan Technologies, Inc. | Method and apparatus for lancet actuation |
US7033371B2 (en) | 2001-06-12 | 2006-04-25 | Pelikan Technologies, Inc. | Electric lancet actuator |
DE60234597D1 (en) | 2001-06-12 | 2010-01-14 | Pelikan Technologies Inc | DEVICE AND METHOD FOR REMOVING BLOOD SAMPLES |
US9427532B2 (en) | 2001-06-12 | 2016-08-30 | Sanofi-Aventis Deutschland Gmbh | Tissue penetration device |
US9795747B2 (en) | 2010-06-02 | 2017-10-24 | Sanofi-Aventis Deutschland Gmbh | Methods and apparatus for lancet actuation |
CA2448902C (en) | 2001-06-12 | 2010-09-07 | Pelikan Technologies, Inc. | Self optimizing lancing device with adaptation means to temporal variations in cutaneous properties |
US7749174B2 (en) | 2001-06-12 | 2010-07-06 | Pelikan Technologies, Inc. | Method and apparatus for lancet launching device intergrated onto a blood-sampling cartridge |
US8337419B2 (en) | 2002-04-19 | 2012-12-25 | Sanofi-Aventis Deutschland Gmbh | Tissue penetration device |
US7041068B2 (en) | 2001-06-12 | 2006-05-09 | Pelikan Technologies, Inc. | Sampling module device and method |
US6683319B1 (en) | 2001-07-17 | 2004-01-27 | Mitec Incorporated | System and method for irradiation with improved dosage uniformity |
WO2003011058A1 (en) * | 2001-07-31 | 2003-02-13 | Institut National De La Recherche Scientifique | Formulations of compounds derived from natural sources and their use with irradiation for food preservation |
US20030031584A1 (en) * | 2001-08-10 | 2003-02-13 | Wilson Burgess | Methods for sterilizing biological materials using dipeptide stabilizers |
US6946098B2 (en) | 2001-08-10 | 2005-09-20 | Clearant, Inc. | Methods for sterilizing biological materials |
US6749851B2 (en) * | 2001-08-31 | 2004-06-15 | Clearant, Inc. | Methods for sterilizing preparations of digestive enzymes |
US20030095890A1 (en) * | 2001-09-24 | 2003-05-22 | Shirley Miekka | Methods for sterilizing biological materials containing non-aqueous solvents |
US20030059338A1 (en) * | 2001-09-24 | 2003-03-27 | Mann David M. | Methods for sterilizing biological materials using flavonoid/flavonol stabilizers |
US20110091353A1 (en) * | 2001-09-24 | 2011-04-21 | Wilson Burgess | Methods for Sterilizing Tissue |
US20030064000A1 (en) * | 2001-09-24 | 2003-04-03 | Wilson Burgess | Methods of sterilizing biological mixtures using stabilizer mixtures |
US20030185702A1 (en) * | 2002-02-01 | 2003-10-02 | Wilson Burgess | Methods for sterilizing tissue |
US20030124023A1 (en) * | 2001-12-21 | 2003-07-03 | Wilson Burgess | Method of sterilizing heart valves |
US20030180181A1 (en) * | 2002-02-01 | 2003-09-25 | Teri Greib | Methods for sterilizing tissue |
IL164191A0 (en) * | 2002-03-26 | 2005-12-18 | Nanocyte Inc | Stinging cells expressing an exogenous polynucleotide encoding a therapeutic, diagnostic or a cosme tic agent and methods compositions and devices utilizing such stinging cells or capsules derived therefrom for delivering the therapeutic, diagnostic or cosmetic agent into a tissue nanocyte inc. |
WO2003086480A1 (en) * | 2002-04-10 | 2003-10-23 | Clearant, Inc. | Methods for sterilizing biological materials |
US8702624B2 (en) | 2006-09-29 | 2014-04-22 | Sanofi-Aventis Deutschland Gmbh | Analyte measurement device with a single shot actuator |
US9248267B2 (en) | 2002-04-19 | 2016-02-02 | Sanofi-Aventis Deustchland Gmbh | Tissue penetration device |
US7229458B2 (en) | 2002-04-19 | 2007-06-12 | Pelikan Technologies, Inc. | Method and apparatus for penetrating tissue |
US7909778B2 (en) | 2002-04-19 | 2011-03-22 | Pelikan Technologies, Inc. | Method and apparatus for penetrating tissue |
US8360992B2 (en) | 2002-04-19 | 2013-01-29 | Sanofi-Aventis Deutschland Gmbh | Method and apparatus for penetrating tissue |
US7297122B2 (en) | 2002-04-19 | 2007-11-20 | Pelikan Technologies, Inc. | Method and apparatus for penetrating tissue |
US7717863B2 (en) | 2002-04-19 | 2010-05-18 | Pelikan Technologies, Inc. | Method and apparatus for penetrating tissue |
US7232451B2 (en) | 2002-04-19 | 2007-06-19 | Pelikan Technologies, Inc. | Method and apparatus for penetrating tissue |
US7491178B2 (en) | 2002-04-19 | 2009-02-17 | Pelikan Technologies, Inc. | Method and apparatus for penetrating tissue |
US8221334B2 (en) | 2002-04-19 | 2012-07-17 | Sanofi-Aventis Deutschland Gmbh | Method and apparatus for penetrating tissue |
US7976476B2 (en) | 2002-04-19 | 2011-07-12 | Pelikan Technologies, Inc. | Device and method for variable speed lancet |
US7648468B2 (en) | 2002-04-19 | 2010-01-19 | Pelikon Technologies, Inc. | Method and apparatus for penetrating tissue |
US8267870B2 (en) | 2002-04-19 | 2012-09-18 | Sanofi-Aventis Deutschland Gmbh | Method and apparatus for body fluid sampling with hybrid actuation |
US7901362B2 (en) | 2002-04-19 | 2011-03-08 | Pelikan Technologies, Inc. | Method and apparatus for penetrating tissue |
US7291117B2 (en) | 2002-04-19 | 2007-11-06 | Pelikan Technologies, Inc. | Method and apparatus for penetrating tissue |
US8579831B2 (en) | 2002-04-19 | 2013-11-12 | Sanofi-Aventis Deutschland Gmbh | Method and apparatus for penetrating tissue |
US7674232B2 (en) | 2002-04-19 | 2010-03-09 | Pelikan Technologies, Inc. | Method and apparatus for penetrating tissue |
US7226461B2 (en) | 2002-04-19 | 2007-06-05 | Pelikan Technologies, Inc. | Method and apparatus for a multi-use body fluid sampling device with sterility barrier release |
US7547287B2 (en) | 2002-04-19 | 2009-06-16 | Pelikan Technologies, Inc. | Method and apparatus for penetrating tissue |
US8372016B2 (en) | 2002-04-19 | 2013-02-12 | Sanofi-Aventis Deutschland Gmbh | Method and apparatus for body fluid sampling and analyte sensing |
US7371247B2 (en) | 2002-04-19 | 2008-05-13 | Pelikan Technologies, Inc | Method and apparatus for penetrating tissue |
US9795334B2 (en) | 2002-04-19 | 2017-10-24 | Sanofi-Aventis Deutschland Gmbh | Method and apparatus for penetrating tissue |
US9314194B2 (en) | 2002-04-19 | 2016-04-19 | Sanofi-Aventis Deutschland Gmbh | Tissue penetration device |
US7331931B2 (en) | 2002-04-19 | 2008-02-19 | Pelikan Technologies, Inc. | Method and apparatus for penetrating tissue |
US7892183B2 (en) | 2002-04-19 | 2011-02-22 | Pelikan Technologies, Inc. | Method and apparatus for body fluid sampling and analyte sensing |
US8784335B2 (en) | 2002-04-19 | 2014-07-22 | Sanofi-Aventis Deutschland Gmbh | Body fluid sampling device with a capacitive sensor |
EP1531823A4 (en) * | 2002-05-10 | 2007-07-18 | Univ Ohio State | Flavin n-oxides: new anti-cancer agents and pathogen eradication agents |
AU2007205748B2 (en) * | 2002-06-07 | 2009-11-26 | Promethean Lifesciences, Inc. | Sterilization, stabilization and preservation of functional biologics |
US6908591B2 (en) * | 2002-07-18 | 2005-06-21 | Clearant, Inc. | Methods for sterilizing biological materials by irradiation over a temperature gradient |
US20040013561A1 (en) * | 2002-07-18 | 2004-01-22 | David Mann | Methods for sterilizing recombinant or transgenic material |
US20040013562A1 (en) * | 2002-07-18 | 2004-01-22 | Wilson Burgess | Methods for sterilizing milk. |
US20080220074A1 (en) * | 2002-10-04 | 2008-09-11 | Elan Corporation Plc | Gamma radiation sterilized nanoparticulate docetaxel compositions and methods of making same |
WO2004032980A1 (en) | 2002-10-04 | 2004-04-22 | Elan Pharma International Limited | Gamma irradiation of solid nanoparticulate active agents |
WO2004052098A1 (en) * | 2002-12-11 | 2004-06-24 | Cryolife, Inc. | Radical retardant cryopreservation solutions |
US8574895B2 (en) | 2002-12-30 | 2013-11-05 | Sanofi-Aventis Deutschland Gmbh | Method and apparatus using optical techniques to measure analyte levels |
US8828226B2 (en) | 2003-03-01 | 2014-09-09 | The Trustees Of Boston University | System for assessing the efficacy of stored red blood cells using microvascular networks |
US7842232B2 (en) * | 2003-05-22 | 2010-11-30 | Elan Pharma International, Ltd. | Sterilization of dispersions of nanoparticulate active agents with gamma radiation |
ES2347248T3 (en) | 2003-05-30 | 2010-10-27 | Pelikan Technologies Inc. | PROCEDURE AND APPLIANCE FOR FLUID INJECTION. |
WO2004107964A2 (en) | 2003-06-06 | 2004-12-16 | Pelikan Technologies, Inc. | Blood harvesting device with electronic control |
WO2006001797A1 (en) | 2004-06-14 | 2006-01-05 | Pelikan Technologies, Inc. | Low pain penetrating |
WO2005030137A2 (en) * | 2003-09-24 | 2005-04-07 | The University Of Toledo, A University Instrumentality Of The State Of Ohio | Improving biomechanical performance of irradiated biological material |
WO2005033659A2 (en) | 2003-09-29 | 2005-04-14 | Pelikan Technologies, Inc. | Method and apparatus for an improved sample capture device |
US9351680B2 (en) | 2003-10-14 | 2016-05-31 | Sanofi-Aventis Deutschland Gmbh | Method and apparatus for a variable user interface |
US20050129569A1 (en) * | 2003-12-15 | 2005-06-16 | Becton, Dickinson And Company | Terminal sterilization of prefilled containers |
US7822454B1 (en) | 2005-01-03 | 2010-10-26 | Pelikan Technologies, Inc. | Fluid sampling device with improved analyte detecting member configuration |
EP1706026B1 (en) | 2003-12-31 | 2017-03-01 | Sanofi-Aventis Deutschland GmbH | Method and apparatus for improving fluidic flow and sample capture |
WO2005072523A2 (en) * | 2004-02-02 | 2005-08-11 | I.M.T. Interface Multigrad Technology Ltd. | Biological material and methods and solutions for preservation thereof |
US8828203B2 (en) | 2004-05-20 | 2014-09-09 | Sanofi-Aventis Deutschland Gmbh | Printable hydrogels for biosensors |
US9820684B2 (en) | 2004-06-03 | 2017-11-21 | Sanofi-Aventis Deutschland Gmbh | Method and apparatus for a fluid sampling device |
US9775553B2 (en) | 2004-06-03 | 2017-10-03 | Sanofi-Aventis Deutschland Gmbh | Method and apparatus for a fluid sampling device |
AU2005307797B2 (en) * | 2004-11-16 | 2011-06-02 | Alkermes Pharma Ireland Limited | Injectable nanoparticulate olanzapine formulations |
CN1298227C (en) * | 2004-12-30 | 2007-02-07 | 上海三生生物技术有限公司 | Effective sterilizing method capable of keeping colostrum immune globulin activity |
US8652831B2 (en) | 2004-12-30 | 2014-02-18 | Sanofi-Aventis Deutschland Gmbh | Method and apparatus for analyte measurement test time |
CA2598288A1 (en) * | 2005-03-03 | 2006-09-14 | Elan Pharma International Limited | Nanoparticulate compositions of heterocyclic amide derivatives |
JP2006289071A (en) * | 2005-03-18 | 2006-10-26 | Toray Ind Inc | Sterilization method for compound |
US8834862B2 (en) * | 2005-04-19 | 2014-09-16 | Nanocyte Inc. | Methods, compositions and devices utilizing stinging cells/capsules for conditioning a tissue prior to delivery of an active agent |
AU2006252342A1 (en) * | 2005-06-02 | 2006-12-07 | Alza Corporation | Method for terminal sterilization of transdermal delivery devices |
US20060280645A1 (en) * | 2005-06-02 | 2006-12-14 | Scott Sellers | Method for terminal sterilization of transdermal delivery devices |
US20070237866A1 (en) * | 2006-03-10 | 2007-10-11 | Mitec Incorporated | Process for the extension of microbial life and color life of fresh meat products |
EP2043623A4 (en) * | 2006-07-12 | 2013-03-20 | Elan Pharma Int Ltd | Nanoparticulate formulations of modafinil |
EP2087109A2 (en) * | 2006-09-08 | 2009-08-12 | Promethean Lifesciences, Inc. | Stabilization of biological materials through inactivation of metalloenzymes |
US7776260B2 (en) * | 2006-12-11 | 2010-08-17 | Ethicon, Inc. | Apparatus and method for the irradiation of radiation sensitive materials |
US7704453B2 (en) * | 2007-06-07 | 2010-04-27 | Ethicon, Inc. | Method for establishing a sterilizing dose for radiation sensitive products |
US8409499B2 (en) * | 2007-06-07 | 2013-04-02 | Ethicon, Inc. | Method for establishing a sterilizing dose for radiation sensitive products |
WO2009126900A1 (en) | 2008-04-11 | 2009-10-15 | Pelikan Technologies, Inc. | Method and apparatus for analyte detecting device |
EP2346324A4 (en) * | 2008-10-06 | 2012-10-10 | Microbial Defense Systems Llc | Antimicrobial composition and methods of making and using same |
US9375169B2 (en) | 2009-01-30 | 2016-06-28 | Sanofi-Aventis Deutschland Gmbh | Cam drive for managing disposable penetrating member actions with a single motor and motor and control system |
WO2011046841A1 (en) | 2009-10-12 | 2011-04-21 | New Health Sciences, Inc. | Blood storage bag system and depletion devices with oxygen and carbon dioxide depletion capabilities |
US9199016B2 (en) | 2009-10-12 | 2015-12-01 | New Health Sciences, Inc. | System for extended storage of red blood cells and methods of use |
WO2011046963A1 (en) | 2009-10-12 | 2011-04-21 | New Health Sciences, Inc. | Oxygen depletion devices and methods for removing oxygen from red blood cells |
US11284616B2 (en) | 2010-05-05 | 2022-03-29 | Hemanext Inc. | Irradiation of red blood cells and anaerobic storage |
WO2011106222A2 (en) * | 2010-02-23 | 2011-09-01 | Corning Incorporated | Modified substrates for protection of peptide-immobilized surfaces from gamma radiation degradation |
US8965476B2 (en) | 2010-04-16 | 2015-02-24 | Sanofi-Aventis Deutschland Gmbh | Tissue penetration device |
CN101862452B (en) * | 2010-07-22 | 2012-06-20 | 山西芮城亚宝兽药有限公司 | Method for preparing swine multi-valent antiserum compound preparation |
WO2012027582A1 (en) | 2010-08-25 | 2012-03-01 | New Health Sciences | Method for enhancing red blood cell quality and survival during storage |
WO2012061731A1 (en) | 2010-11-05 | 2012-05-10 | New Health Sciences | Irradiation of red blood cells and anaerobic storage |
US9067004B2 (en) | 2011-03-28 | 2015-06-30 | New Health Sciences, Inc. | Method and system for removing oxygen and carbon dioxide during red cell blood processing using an inert carrier gas and manifold assembly |
EP2706845B1 (en) | 2011-05-10 | 2021-06-23 | Next Science IP Holdings Pty Ltd | Antimicrobial solid and methods of making and using same |
CA2844449A1 (en) | 2011-08-10 | 2013-02-14 | New Health Sciences, Inc. | Integrated leukocyte, oxygen and/or co2 depletion, and plasma separation filter device |
IL294717B2 (en) | 2012-02-17 | 2023-08-01 | Alcresta Inc | Methods, compositions, and devices for supplying dietary fatty acid needs |
US10314944B2 (en) | 2012-05-11 | 2019-06-11 | Rti Surgical, Inc. | Xenograft soft tissue implants and methods of making and using |
CA3205441A1 (en) | 2013-02-28 | 2014-09-04 | Hemanext Inc. | Gas depletion and gas addition devices for blood treatment |
EP3202389A4 (en) * | 2014-10-02 | 2018-06-20 | Terumo Kabushiki Kaisha | Medical container for accommodating protein solution preparation therein |
CA2978940C (en) | 2015-03-10 | 2023-10-17 | New Health Sciences, Inc. | Oxygen reduction disposable kits, devices and methods of use thereof |
WO2016172645A1 (en) | 2015-04-23 | 2016-10-27 | New Health Sciences, Inc. | Anaerobic blood storage containers |
WO2016187353A1 (en) | 2015-05-18 | 2016-11-24 | New Health Sciences, Inc. | Methods for the storage of whole blood, and compositions thereof |
US10258590B2 (en) | 2015-10-14 | 2019-04-16 | Alcresta Therapeutics, Inc. | Enteral feeding device and related methods of use |
US20200221739A1 (en) * | 2016-03-28 | 2020-07-16 | The King Abdulaziz City For Science And Technology | Method for removal of antibiotic residues from food products |
CN109195632A (en) | 2016-05-27 | 2019-01-11 | 新健康科学股份有限公司 | Anaerobism blood storage and pathogen method for deactivating |
US11045396B2 (en) | 2017-08-17 | 2021-06-29 | Alcresta Therapeutics, Inc. | Devices and methods for the supplementation of a nutritional formula |
CA3078625C (en) | 2017-10-09 | 2023-01-17 | Terumo Bct Biotechnologies, Llc | Lyophilization container and method of using same |
EP3937878A2 (en) | 2019-03-14 | 2022-01-19 | Terumo BCT Biotechnologies, LLC | Lyophilization loading tray assembly and system |
EP3982909A4 (en) * | 2019-06-12 | 2023-11-29 | Avadim Health, Inc. | Compositions and methods for the antiseptic treatment of biofilms on mammalian tissue |
WO2023244189A1 (en) * | 2022-06-15 | 2023-12-21 | Acibadem Mehmet Ali̇ Aydinlar Üni̇versi̇tesi̇ | A method for the production of a product used for immune modulation and regeneration purposes in alopecia areata, androgenetic alopecia, scar, neurodegenerative inflammatory diseases |
Citations (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4620908A (en) * | 1983-10-03 | 1986-11-04 | Biocell Laboratories, Inc. | Method for destroying microbial contamination in protein materials |
EP0334679A2 (en) * | 1988-03-25 | 1989-09-27 | National Research Development Corporation | Improvements in or relating to the inactivation of infectious agents |
WO1990000907A1 (en) * | 1988-07-20 | 1990-02-08 | Salford University Business Services Limited | Sterilising methods |
WO1991016060A1 (en) * | 1990-04-16 | 1991-10-31 | Cryopharm Corporation | Method of inactivation of viral and bacterial blood contaminants |
Family Cites Families (85)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
USRE23195E (en) | 1950-02-07 | Preserving | ||
US2832689A (en) * | 1952-01-24 | 1958-04-29 | Research Corp | Preservation of organic materials by irradiation |
US2920969A (en) * | 1954-08-25 | 1960-01-12 | Gen Electric | Method and means for irradiating foods |
US2962380A (en) * | 1956-10-08 | 1960-11-29 | Research Corp | Radiation sterilization of fluid food products |
US3620944A (en) * | 1967-09-09 | 1971-11-16 | Osaka Prefecture | Process of purifying water by irradiating it |
US3743480A (en) | 1971-04-09 | 1973-07-03 | Allied Chem | Sterilization of biological fluids |
US3779706A (en) | 1971-10-04 | 1973-12-18 | Energy Sciences Inc | Process for bulk sterilization, minimizing chemical and physical damage |
US4136094A (en) | 1977-08-31 | 1979-01-23 | The Regents Of The University Of Minnesota | Preparation of intravenous human and animal gamma globulins and isolation of albumin |
US4282863A (en) | 1978-07-20 | 1981-08-11 | Beigler Myron A | Methods of preparing and using intravenous nutrient compositions |
US4336247A (en) | 1978-09-05 | 1982-06-22 | Eriksen Arthur E | Body system nutrient material |
IL58541A (en) | 1978-11-01 | 1982-02-28 | Nordisk Insulinlab | Antihemophilic factor preparation from human blood plasma and a process for producing it |
US4330626A (en) | 1980-03-19 | 1982-05-18 | The Enzyme Center, Inc. | Method of preparing high-activity, low-bacteria, urease enzyme |
DE3033932C2 (en) | 1980-09-10 | 1984-05-24 | Biotest-Serum-Institut Gmbh, 6000 Frankfurt | Process for the cold sterilization of preparations containing blood coagulation factor VIII |
JPS57103649A (en) | 1980-12-18 | 1982-06-28 | Asahi Chemical Ind | Sterilized gamma-globulin fixing column |
US4472840A (en) | 1981-09-21 | 1984-09-25 | Jefferies Steven R | Method of inducing osseous formation by implanting bone graft material |
US4963356A (en) | 1982-10-13 | 1990-10-16 | Minnesota Mining And Manufacturing Company | Stable antigenic extracts methods |
US5106619A (en) | 1983-12-20 | 1992-04-21 | Diamond Scientific Co. | Preparation of inactivated viral vaccines |
JPH0687062B2 (en) * | 1985-05-10 | 1994-11-02 | 株式会社京都医科学研究所 | How to prevent glycolysis in blood |
SU1321420A1 (en) * | 1985-06-19 | 1987-07-07 | Московский научно-исследовательский институт микрохирургии глаза | Method of collagen coating for ophthalmological use |
US4784850A (en) | 1985-09-04 | 1988-11-15 | Mutzarei Maabarot | Process for preparing antibodies against E. Coli K-99 antigen from bovine milk |
KR880000038A (en) * | 1986-02-04 | 1988-03-23 | 백영수 | Sterilization Storage Method of Fruits |
US5185371A (en) * | 1986-03-10 | 1993-02-09 | University Of Southern California | Method for disinfecting red blood cells |
US4798611A (en) | 1986-10-14 | 1989-01-17 | Hancock Jaffe Laboratories | Enhancement of xenogeneic tissue |
JPH0611290B2 (en) * | 1986-11-05 | 1994-02-16 | 住友ベークライト株式会社 | Γ-ray sterilization method for polyvinyl alcohol gel |
US4865602A (en) | 1986-11-06 | 1989-09-12 | Collagen Corporation | Gamma irradiation of collagen/mineral mixtures |
US5000951A (en) | 1987-03-09 | 1991-03-19 | Diamond Scientific Company | Multivalent canine distemper virus vaccine |
DE3730533A1 (en) | 1987-09-11 | 1989-03-30 | Biotest Pharma Gmbh | METHOD FOR STERILIZING PLASMA OR PLASMA FACTIONS |
ES2067474T3 (en) | 1987-09-28 | 1995-04-01 | Beecham Inc | PORK TGEV VIRUSES AS A VACCINE FOR DOGS. |
US4931361A (en) | 1988-11-18 | 1990-06-05 | California Institute Of Technology | Cryoprotective reagents in freeze-drying membranes |
US5643464A (en) | 1988-11-21 | 1997-07-01 | Collagen Corporation | Process for preparing a sterile, dry crosslinking agent |
US5055485A (en) * | 1988-12-02 | 1991-10-08 | New York Blood Center, Inc. | Inactivation of viruses in cell- and protein-containing compositions using aryl diol epoxides |
US5044091B1 (en) | 1989-04-18 | 1997-12-30 | Sankyo Co | Method of preparing a freeze-dried formulation of a drug |
US5283034A (en) | 1989-06-29 | 1994-02-01 | Applied Immune Sciences, Inc. | Stabilization of sterilized surfaces for research and medical use |
US5226065A (en) * | 1989-10-13 | 1993-07-06 | Stericycle, Inc. | Device for disinfecting medical materials |
US6187572B1 (en) | 1990-04-16 | 2001-02-13 | Baxter International Inc. | Method of inactivation of viral and bacterial blood contaminants |
JP3373201B2 (en) | 1990-04-16 | 2003-02-04 | バクスター インターナショナル インコーポレーテッド | Inactivation method of blood contaminants of viruses and bacteria |
US5418130A (en) * | 1990-04-16 | 1995-05-23 | Cryopharm Corporation | Method of inactivation of viral and bacterial blood contaminants |
DE4012398A1 (en) * | 1990-04-19 | 1991-10-24 | Waelischmiller Hans Dipl Ing F | RADIATION DEVICE |
US5981163A (en) | 1990-05-15 | 1999-11-09 | New York Blood Center, Inc. | Process for the sterilization of biological compositions using irradiation and quenchers of type I and type II photodynamic reactions |
US5712086A (en) | 1990-05-15 | 1998-01-27 | New York Blood Center, Inc. | Process for transfusing cell containing fractions sterilized with radiation and a quencher of type I and type II photodynamic reactions |
US5658722A (en) | 1990-05-15 | 1997-08-19 | New York Blood Center, Inc. | Process for the sterilization of biological compositions using UVA1 irradiation |
US5120649A (en) * | 1990-05-15 | 1992-06-09 | New York Blood Center, Inc. | Photodynamic inactivation of viruses in blood cell-containing compositions |
US5360605A (en) | 1990-09-04 | 1994-11-01 | Edward Shanbrom | Preservation of blood, tissues and biological fluids |
US5336616A (en) * | 1990-09-12 | 1994-08-09 | Lifecell Corporation | Method for processing and preserving collagen-based tissues for transplantation |
US5362442A (en) * | 1993-07-22 | 1994-11-08 | 2920913 Canada Inc. | Method for sterilizing products with gamma radiation |
US5460962A (en) | 1994-01-04 | 1995-10-24 | Organogenesis Inc. | Peracetic acid sterilization of collagen or collagenous tissue |
US6203755B1 (en) | 1994-03-04 | 2001-03-20 | St. Jude Medical, Inc. | Electron beam sterilization of biological tissues |
EP0804734B1 (en) | 1994-05-13 | 2005-05-04 | Miltenyi Biotec GmbH | Sterile and pyrogen-free columns coupled to protein for binding and removal of substances from blood |
SE9401986D0 (en) | 1994-06-08 | 1994-06-08 | Pharmacia Ab | New process for sterilization and articles sterilized thereby |
US5510122A (en) | 1994-09-28 | 1996-04-23 | The Research Foundation Of State University Of New York | Preparation and use of whole saliva |
US5603894A (en) | 1994-10-31 | 1997-02-18 | Abbott Laboratories | Method of sterilizing a pharmaceutical composition |
US5548066A (en) | 1994-12-02 | 1996-08-20 | Central Biomedia, Inc. | Failure of passive transfer immune serum and method of making same |
US5637451A (en) | 1995-03-29 | 1997-06-10 | New York Blood Center, Inc. | Photodynamic treatment of red blood cells with phthalocyanines and red light at higher light fluence rates is protective of red blood cells |
US5837313A (en) | 1995-04-19 | 1998-11-17 | Schneider (Usa) Inc | Drug release stent coating process |
JP3799626B2 (en) | 1995-04-25 | 2006-07-19 | 有限会社ナイセム | Cardiovascular repair material and method for producing the same |
US5674292A (en) * | 1995-06-07 | 1997-10-07 | Stryker Corporation | Terminally sterilized osteogenic devices and preparation thereof |
US6235508B1 (en) | 1995-06-07 | 2001-05-22 | Baxter International Inc. | Method of inactivation of viral and bacterial blood contaminants |
US6049025A (en) | 1995-09-15 | 2000-04-11 | Stone; Kevin R. | Articular cartilage xenografts |
US5691152A (en) | 1995-11-09 | 1997-11-25 | E. R. Squibb & Sons, Inc. | Stable avidin composition |
US5730933A (en) | 1996-04-16 | 1998-03-24 | Depuy Orthopaedics, Inc. | Radiation sterilization of biologically active compounds |
US6060233A (en) | 1996-06-14 | 2000-05-09 | Biostore New Zealand, Ltd | Methods for the lyophilization of platelets, platelet membranes or erythrocytes |
US5945128A (en) | 1996-09-04 | 1999-08-31 | Romano Deghenghi | Process to manufacture implants containing bioactive peptides |
US6190855B1 (en) | 1996-10-28 | 2001-02-20 | Baxter International Inc. | Systems and methods for removing viral agents from blood |
US6696270B2 (en) * | 1996-12-10 | 2004-02-24 | Purdue Research Foundation | Gastric submucosal tissue as a novel diagnostic tool |
US5856172A (en) | 1997-01-03 | 1999-01-05 | Quality Technologies, Llc | Preservation of microorganisms in a vial with a cap comprising an immobilized desiccant |
US6383810B2 (en) * | 1997-02-14 | 2002-05-07 | Invitrogen Corporation | Dry powder cells and cell culture reagents and methods of production thereof |
CA2217437A1 (en) | 1997-04-25 | 1998-10-25 | Mohamed Ressouany | Biodegradable caseinate films and process for their production by irradiation |
US6197207B1 (en) | 1997-05-21 | 2001-03-06 | Baxter International Inc. | Method of reducing the possibility of transmission of spongiform encephalopathy diseases by blood products |
US6010719A (en) | 1997-09-16 | 2000-01-04 | Universiteit Gent | Freeze-dried disintegrating tablets |
EP2147681A1 (en) | 1997-10-29 | 2010-01-27 | Genzyme Corporation | Compositions and methods for treating lysosomal storage disease |
DE19751284A1 (en) | 1997-11-19 | 1999-05-27 | Leo Prof Dr Gotzen | Fixation element |
US6000044A (en) | 1997-11-26 | 1999-12-07 | Digital Equipment Corporation | Apparatus for randomly sampling instructions in a processor pipeline |
DE19849984A1 (en) | 1998-10-29 | 2000-05-04 | Tutogen Medical Inc | Process for the preparation of bone material |
US20030068815A1 (en) * | 1999-02-11 | 2003-04-10 | Stone Kevin R. | Sterilized xenograft tissue |
US6258821B1 (en) | 1999-04-26 | 2001-07-10 | Medimmune Oncology, Inc. | Compositions comprising trimetrexate and methods of their synthesis and use |
DE29913200U1 (en) | 1999-07-28 | 1999-09-23 | Tutogen Medical Gmbh | Bone material implant |
CN1120747C (en) | 1999-08-17 | 2003-09-10 | 流动程序技术公司 | Recovery process for oxidation catalyst in the manufacture of aromatic carboxylic acid |
DE19952550A1 (en) | 1999-11-02 | 2001-05-03 | Tutogen Medical Gmbh | Bone implant |
DE19952939A1 (en) | 1999-11-03 | 2001-05-10 | Tutogen Medical Gmbh | Bone material implant |
DE19962248A1 (en) | 1999-12-22 | 2001-06-28 | Tutogen Medical Gmbh | Producing bone material containing bone morphogenic protein, useful as transplant for accelerating bone growth, includes resorbable material for sustained release of protein |
US6379385B1 (en) | 2000-01-06 | 2002-04-30 | Tutogen Medical Gmbh | Implant of bone matter |
DE10014617A1 (en) | 2000-03-24 | 2001-09-27 | Tutogen Medical Gmbh | Orthopedic interference screw especially useful in crucial ligament repair has both the screw body and head made from human or animal bone preferably obtained by dehydration |
DE10014616A1 (en) | 2000-03-24 | 2001-09-27 | Tutogen Medical Gmbh | Cranium implant for use in brain surgery consists of a plate of spongy, cortical or compact bone material of human or animal origin preferably obtained by dehydration |
DE10026306A1 (en) | 2000-05-26 | 2001-11-29 | Tutogen Medical Gmbh | Jawbone transplant is domed and can be bent to U-shapes and is made of spongiose, cortical or compact bone material of human or animal origin |
AU2002310364B2 (en) * | 2001-06-08 | 2006-02-23 | Morris Innovative Research, Inc. | Method and apparatus for sealing access |
-
1993
- 1993-07-22 US US08/095,698 patent/US5362442A/en not_active Expired - Lifetime
-
1994
- 1994-07-22 ES ES94922207T patent/ES2197907T3/en not_active Expired - Lifetime
- 1994-07-22 KR KR1019960700298A patent/KR100389846B1/en not_active IP Right Cessation
- 1994-07-22 WO PCT/CA1994/000401 patent/WO1995003071A1/en active IP Right Grant
- 1994-07-22 AT AT94922207T patent/ATE235262T1/en not_active IP Right Cessation
- 1994-07-22 DK DK94922207T patent/DK0710124T3/en active
- 1994-07-22 DE DE69432351T patent/DE69432351T2/en not_active Expired - Fee Related
- 1994-07-22 PT PT94922207T patent/PT710124E/en unknown
- 1994-07-22 CA CA002167528A patent/CA2167528C/en not_active Expired - Fee Related
- 1994-07-22 NZ NZ269786A patent/NZ269786A/en unknown
- 1994-07-22 AU AU73434/94A patent/AU687425B2/en not_active Ceased
- 1994-07-22 JP JP7504833A patent/JPH09500553A/en active Pending
- 1994-07-22 BR BR9407138A patent/BR9407138A/en not_active Application Discontinuation
- 1994-07-22 EP EP94922207A patent/EP0710124B1/en not_active Expired - Lifetime
-
1995
- 1995-12-15 US US08/573,149 patent/US6171549B1/en not_active Expired - Fee Related
-
1996
- 1996-01-19 FI FI960281A patent/FI960281A/en not_active Application Discontinuation
-
2000
- 2000-05-15 US US09/570,929 patent/US6346216B1/en not_active Expired - Fee Related
-
2001
- 2001-11-05 US US09/985,606 patent/US6635222B2/en not_active Expired - Fee Related
-
2003
- 2003-01-14 US US10/341,355 patent/US20030143107A1/en not_active Abandoned
-
2007
- 2007-08-22 US US11/843,165 patent/US20080176306A1/en not_active Abandoned
Patent Citations (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4620908A (en) * | 1983-10-03 | 1986-11-04 | Biocell Laboratories, Inc. | Method for destroying microbial contamination in protein materials |
EP0334679A2 (en) * | 1988-03-25 | 1989-09-27 | National Research Development Corporation | Improvements in or relating to the inactivation of infectious agents |
WO1990000907A1 (en) * | 1988-07-20 | 1990-02-08 | Salford University Business Services Limited | Sterilising methods |
WO1991016060A1 (en) * | 1990-04-16 | 1991-10-31 | Cryopharm Corporation | Method of inactivation of viral and bacterial blood contaminants |
Cited By (11)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6635222B2 (en) | 1993-07-22 | 2003-10-21 | Clearant, Inc. | Method of sterilizing products |
DE19543503A1 (en) * | 1995-11-22 | 1997-05-28 | Nukem Gmbh | Exposing fluid to intense radiation |
DE19543503C2 (en) * | 1995-11-22 | 2000-01-05 | Nukem Gmbh | Method and device for irradiating liquids with high-energy radiation and use of the device |
US6682695B2 (en) | 2001-03-23 | 2004-01-27 | Clearant, Inc. | Methods for sterilizing biological materials by multiple rates |
US6696060B2 (en) | 2001-06-14 | 2004-02-24 | Clearant, Inc. | Methods for sterilizing preparations of monoclonal immunoglobulins |
US7252799B2 (en) | 2001-08-31 | 2007-08-07 | Clearant, Inc. | Methods for sterilizing preparations containing albumin |
US6783968B2 (en) | 2001-09-24 | 2004-08-31 | Clearant, Inc. | Methods for sterilizing preparations of glycosidases |
WO2003103390A1 (en) * | 2002-06-07 | 2003-12-18 | Promethean Lifesciences, Inc. | Sterilization, stabilization and preservation of functional biologics |
AU2003237391B2 (en) * | 2002-06-07 | 2007-08-30 | Promethean Lifesciences, Inc. | Sterilization, stabilization and preservation of functional biologics |
US8580192B2 (en) | 2006-10-31 | 2013-11-12 | Ethicon, Inc. | Sterilization of polymeric materials |
US8585965B2 (en) | 2006-10-31 | 2013-11-19 | Ethicon, Inc. | Sterilization of polymeric materials |
Also Published As
Publication number | Publication date |
---|---|
FI960281A (en) | 1996-03-18 |
US6171549B1 (en) | 2001-01-09 |
US6635222B2 (en) | 2003-10-21 |
NZ269786A (en) | 1998-03-25 |
PT710124E (en) | 2003-08-29 |
DE69432351T2 (en) | 2004-02-19 |
US20030143107A1 (en) | 2003-07-31 |
CA2167528C (en) | 2005-02-01 |
US6346216B1 (en) | 2002-02-12 |
EP0710124B1 (en) | 2003-03-26 |
ES2197907T3 (en) | 2004-01-16 |
EP0710124A1 (en) | 1996-05-08 |
US20030059339A1 (en) | 2003-03-27 |
DE69432351D1 (en) | 2003-04-30 |
BR9407138A (en) | 1996-09-17 |
AU7343494A (en) | 1995-02-20 |
US20080176306A1 (en) | 2008-07-24 |
AU687425B2 (en) | 1998-02-26 |
DK0710124T3 (en) | 2003-07-21 |
FI960281A0 (en) | 1996-01-19 |
JPH09500553A (en) | 1997-01-21 |
ATE235262T1 (en) | 2003-04-15 |
US5362442A (en) | 1994-11-08 |
KR960703625A (en) | 1996-08-31 |
KR100389846B1 (en) | 2003-10-30 |
CA2167528A1 (en) | 1995-02-02 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
EP0710124B1 (en) | Method for sterilizing products | |
AU2001259031B2 (en) | Methods for sterilizing biological materials | |
AU2003237391B2 (en) | Sterilization, stabilization and preservation of functional biologics | |
AU2001259031A1 (en) | Methods for sterilizing biological materials | |
US20040067157A1 (en) | Methods for sterilizing biological materials | |
US20040013562A1 (en) | Methods for sterilizing milk. | |
US20080220492A1 (en) | Stabilization of biological materials through inactivation of metalloenzymes | |
AU2007205748B2 (en) | Sterilization, stabilization and preservation of functional biologics | |
US20040013561A1 (en) | Methods for sterilizing recombinant or transgenic material | |
US20060140815A1 (en) | Methods for sterilizing biological materials | |
IL165451A (en) | Methods for preserving functional biological materials |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
AK | Designated states |
Kind code of ref document: A1 Designated state(s): AM AT AU BB BG BR BY CA CH CN CZ DE DK ES FI GB GE HU JP KE KG KP KR KZ LK LT LU LV MD MG MN MW NL NO NZ PL PT RO RU SD SE SI SK TJ TT UA US UZ VN |
|
AL | Designated countries for regional patents |
Kind code of ref document: A1 Designated state(s): KE MW SD AT BE CH DE DK ES FR GB GR IE IT LU MC NL PT SE BF BJ CF CG CI CM GA GN ML MR NE SN TD TG |
|
DFPE | Request for preliminary examination filed prior to expiration of 19th month from priority date (pct application filed before 20040101) | ||
121 | Ep: the epo has been informed by wipo that ep was designated in this application | ||
WWE | Wipo information: entry into national phase |
Ref document number: 08573149 Country of ref document: US |
|
WWE | Wipo information: entry into national phase |
Ref document number: 2167528 Country of ref document: CA |
|
WWE | Wipo information: entry into national phase |
Ref document number: 960281 Country of ref document: FI |
|
WWE | Wipo information: entry into national phase |
Ref document number: 1019960700298 Country of ref document: KR |
|
WWE | Wipo information: entry into national phase |
Ref document number: 269786 Country of ref document: NZ |
|
WWE | Wipo information: entry into national phase |
Ref document number: 1994922207 Country of ref document: EP |
|
WWP | Wipo information: published in national office |
Ref document number: 1994922207 Country of ref document: EP |
|
REG | Reference to national code |
Ref country code: DE Ref legal event code: 8642 |
|
WWG | Wipo information: grant in national office |
Ref document number: 1994922207 Country of ref document: EP |