WO1995010307A1 - Radiation sensitization using texaphyrins - Google Patents
Radiation sensitization using texaphyrins Download PDFInfo
- Publication number
- WO1995010307A1 WO1995010307A1 PCT/US1994/011491 US9411491W WO9510307A1 WO 1995010307 A1 WO1995010307 A1 WO 1995010307A1 US 9411491 W US9411491 W US 9411491W WO 9510307 A1 WO9510307 A1 WO 9510307A1
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- texaphyrin
- radiation
- site
- hydrogen
- alkyl
- Prior art date
Links
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- 206010070834 Sensitisation Diseases 0.000 title description 26
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- A61K51/04—Organic compounds
- A61K51/0474—Organic compounds complexes or complex-forming compounds, i.e. wherein a radioactive metal (e.g. 111In3+) is complexed or chelated by, e.g. a N2S2, N3S, NS3, N4 chelating group
- A61K51/0485—Porphyrins, texaphyrins wherein the nitrogen atoms forming the central ring system complex the radioactive metal
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Abstract
Description
Claims
Priority Applications (13)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP51197695A JP3596816B2 (en) | 1993-10-12 | 1994-10-12 | Radiosensitization using texaphyrin |
DK94931812T DK0724457T3 (en) | 1993-10-12 | 1994-10-12 | Radiation sensitization using texaphyrins |
AT94931812T ATE233575T1 (en) | 1993-10-12 | 1994-10-12 | TEXAPHYRINE AS A RADIATION SENSITIZER |
AU80756/94A AU683316B2 (en) | 1993-10-12 | 1994-10-12 | Radiation sensitization using texaphyrins |
CA002173319A CA2173319C (en) | 1993-10-12 | 1994-10-12 | Radiation sensitization using texaphyrins |
SI9430442T SI0724457T1 (en) | 1993-10-12 | 1994-10-12 | Radiation sensitization using texaphyrins |
NZ275217A NZ275217A (en) | 1993-10-12 | 1994-10-12 | Texaphyrin derivatives and their use as radiation sensitisers |
DE69432221T DE69432221T2 (en) | 1993-10-12 | 1994-10-12 | TEXAPHYRINE AS A SENSITIZER FOR RADIATION |
EP94931812A EP0724457B1 (en) | 1993-10-12 | 1994-10-12 | Radiation sensitization using texaphyrins |
NO19961436A NO315185B1 (en) | 1993-10-12 | 1996-04-11 | Use of Gd and Lu texaphyrins in the preparation of a pharmaceutical composition for use as an irradiation sensitizer |
US08/775,261 US5969111A (en) | 1994-04-14 | 1997-02-04 | Texaphyrins substituted with imidazole are provided |
US08/970,864 US6069140A (en) | 1992-01-21 | 1997-11-14 | Pharmaceutical compositions comprising texaphyrins |
US09/104,870 US6072038A (en) | 1992-01-21 | 1998-06-25 | Conjugates of texaphyrins |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US08/135,118 US5457183A (en) | 1989-03-06 | 1993-10-12 | Hydroxylated texaphyrins |
US08/135,118 | 1993-10-12 |
Related Parent Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
US08/135,118 Continuation-In-Part US5457183A (en) | 1989-03-06 | 1993-10-12 | Hydroxylated texaphyrins |
Related Child Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
US08/437,968 Continuation US5622946A (en) | 1992-01-21 | 1995-05-10 | Radiation sensitization using texaphyrins |
Publications (1)
Publication Number | Publication Date |
---|---|
WO1995010307A1 true WO1995010307A1 (en) | 1995-04-20 |
Family
ID=22466636
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/US1994/011491 WO1995010307A1 (en) | 1992-01-21 | 1994-10-12 | Radiation sensitization using texaphyrins |
Country Status (15)
Country | Link |
---|---|
US (8) | US5457183A (en) |
EP (1) | EP0724457B1 (en) |
JP (2) | JP3596816B2 (en) |
KR (1) | KR100365058B1 (en) |
AT (1) | ATE233575T1 (en) |
AU (1) | AU683316B2 (en) |
CA (1) | CA2173319C (en) |
DE (1) | DE69432221T2 (en) |
DK (1) | DK0724457T3 (en) |
ES (1) | ES2193163T3 (en) |
NO (1) | NO315185B1 (en) |
NZ (1) | NZ275217A (en) |
PT (1) | PT724457E (en) |
SG (1) | SG48392A1 (en) |
WO (1) | WO1995010307A1 (en) |
Cited By (17)
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---|---|---|---|---|
WO1996002274A1 (en) * | 1994-07-14 | 1996-02-01 | Schering Aktiengesellschaft | Conjugates made of metal complexes and oligonucleotides |
WO1997034637A2 (en) * | 1996-03-22 | 1997-09-25 | Trustees Of Boston University | Photodynamic therapy using nuclear hormone receptors to target photosensitizers |
WO1997035617A1 (en) * | 1996-03-26 | 1997-10-02 | Pharmacyclics, Inc. | Use of a texaphyrin in photodynamic therapy of pigment-related lesions |
WO1997046262A2 (en) * | 1996-06-04 | 1997-12-11 | Pharmacyclics, Inc. | Membrane incorporation of texaphyrins |
DE19646762A1 (en) * | 1996-11-04 | 1998-05-07 | Schering Ag | Well tolerated diagnostic agent or radio-sensitiser |
WO1999016474A1 (en) * | 1997-09-26 | 1999-04-08 | Schering Aktiengesellschaft | Lipophilic metal complexes for necrosis and infarct imaging |
WO2000001698A1 (en) * | 1998-07-03 | 2000-01-13 | Schering Aktiengesellschaft | Porphyrin derivatives and their use in photodynamic therapy and mri diagnosis |
US6022959A (en) * | 1996-08-20 | 2000-02-08 | Pharmacyclics, Inc. | Nucleic acids internally-derivatized with a texaphyrin metal complex and uses thereof |
US6022526A (en) * | 1997-07-30 | 2000-02-08 | Pharmacyclics, Inc. | Use of texaphyrins in detection of melanin and melanin metabolites diagnostic of melanotic melanoma |
WO2001032210A3 (en) * | 1999-10-29 | 2002-02-07 | Pharmacyclics Inc | Compositions for treating atheroma and neoplastic tissue |
US6375930B2 (en) | 1996-06-04 | 2002-04-23 | Board Of Regents, The University Of Texas System | Membrane incorporation of texaphyrins |
US6638924B2 (en) | 2000-08-30 | 2003-10-28 | Pharmacyclics, Inc. | Metallotexaphyrin derivatives |
US6723750B2 (en) | 2002-03-15 | 2004-04-20 | Allergan, Inc. | Photodynamic therapy for pre-melanomas |
US7112671B2 (en) | 2000-08-30 | 2006-09-26 | Pharmacyclics, Inc. | Non-symmetric tripyrranes in the synthesis of novel macrocycles |
EP1704870A1 (en) | 2005-03-25 | 2006-09-27 | Nipro Corporation | Use of iron compounds as radiosensitizers |
US7449454B2 (en) | 2000-08-30 | 2008-11-11 | Pharmacyclics, Inc. | Metallotexaphyrin derivatives |
US8410263B2 (en) | 2005-09-26 | 2013-04-02 | Pharmacyclics, Inc. | High-purity texaphyrin metal complexes |
Families Citing this family (691)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5252720A (en) * | 1989-03-06 | 1993-10-12 | Board Of Regents, The University Of Texas System | Metal complexes of water soluble texaphyrins |
US5457183A (en) * | 1989-03-06 | 1995-10-10 | Board Of Regents, The University Of Texas System | Hydroxylated texaphyrins |
US5594136A (en) * | 1989-12-21 | 1997-01-14 | Pharmacyclics, Inc. | Texaphyrin solid supports and devices |
US6335434B1 (en) | 1998-06-16 | 2002-01-01 | Isis Pharmaceuticals, Inc., | Nucleosidic and non-nucleosidic folate conjugates |
US8153602B1 (en) | 1991-11-19 | 2012-04-10 | Isis Pharmaceuticals, Inc. | Composition and methods for the pulmonary delivery of nucleic acids |
US5595726A (en) * | 1992-01-21 | 1997-01-21 | Pharmacyclics, Inc. | Chromophore probe for detection of nucleic acid |
US5607924A (en) * | 1992-01-21 | 1997-03-04 | Pharmacyclics, Inc. | DNA photocleavage using texaphyrins |
US5763172A (en) * | 1992-01-21 | 1998-06-09 | Board Of Regents, The University Of Texas System | Method of phosphate ester hydrolysis |
US5888997A (en) * | 1994-04-14 | 1999-03-30 | Pharmacyclics, Inc. | Radiation sensitization using texaphyrins |
US5565552A (en) * | 1992-01-21 | 1996-10-15 | Pharmacyclics, Inc. | Method of expanded porphyrin-oligonucleotide conjugate synthesis |
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CA2173319A1 (en) | 1995-04-20 |
SG48392A1 (en) | 1998-04-17 |
US5457183A (en) | 1995-10-10 |
DE69432221D1 (en) | 2003-04-10 |
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NO315185B1 (en) | 2003-07-28 |
ES2193163T3 (en) | 2003-11-01 |
PT724457E (en) | 2003-07-31 |
NO961436L (en) | 1996-06-11 |
JP3596816B2 (en) | 2004-12-02 |
JPH09508616A (en) | 1997-09-02 |
US6069140A (en) | 2000-05-30 |
AU683316B2 (en) | 1997-11-06 |
EP0724457A1 (en) | 1996-08-07 |
NO961436D0 (en) | 1996-04-11 |
KR100365058B1 (en) | 2003-05-09 |
KR960704582A (en) | 1996-10-09 |
US5583220A (en) | 1996-12-10 |
DK0724457T3 (en) | 2003-06-30 |
US5801229A (en) | 1998-09-01 |
AU8075694A (en) | 1995-05-04 |
EP0724457B1 (en) | 2003-03-05 |
NZ275217A (en) | 2001-06-29 |
ATE233575T1 (en) | 2003-03-15 |
US5580543A (en) | 1996-12-03 |
CA2173319C (en) | 2008-03-25 |
US5622946A (en) | 1997-04-22 |
JP2004091495A (en) | 2004-03-25 |
US5632970A (en) | 1997-05-27 |
DE69432221T2 (en) | 2003-12-04 |
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