WO1995022991A3 - Block copolymers - Google Patents

Block copolymers Download PDF

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Publication number
WO1995022991A3
WO1995022991A3 PCT/GB1995/000418 GB9500418W WO9522991A3 WO 1995022991 A3 WO1995022991 A3 WO 1995022991A3 GB 9500418 W GB9500418 W GB 9500418W WO 9522991 A3 WO9522991 A3 WO 9522991A3
Authority
WO
WIPO (PCT)
Prior art keywords
block copolymers
units
prodrugs
prodrug
moiety
Prior art date
Application number
PCT/GB1995/000418
Other languages
French (fr)
Other versions
WO1995022991A2 (en
Inventor
Eugene Cooper
Stephen Jones
Colin Pouton
Michael Threadgill
Original Assignee
Nycomed Imaging As
Eugene Cooper
Stephen Jones
Colin Pouton
Michael Threadgill
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Nycomed Imaging As, Eugene Cooper, Stephen Jones, Colin Pouton, Michael Threadgill filed Critical Nycomed Imaging As
Priority to JP7522220A priority Critical patent/JPH09509443A/en
Priority to MX9603680A priority patent/MX9603680A/en
Priority to EP95909864A priority patent/EP0748226A1/en
Priority to AU18170/95A priority patent/AU1817095A/en
Publication of WO1995022991A2 publication Critical patent/WO1995022991A2/en
Publication of WO1995022991A3 publication Critical patent/WO1995022991A3/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/06—Linear peptides containing only normal peptide links having 5 to 11 amino acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
    • A61K47/59—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes
    • A61K47/60—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes the organic macromolecular compound being a polyoxyalkylene oligomer, polymer or dendrimer, e.g. PEG, PPG, PEO or polyglycerol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/62—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/0002—General or multifunctional contrast agents, e.g. chelated agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/08—Tripeptides
    • C07K5/0802—Tripeptides with the first amino acid being neutral
    • C07K5/0812—Tripeptides with the first amino acid being neutral and aromatic or cycloaliphatic
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/10—Tetrapeptides
    • C07K5/1002—Tetrapeptides with the first amino acid being neutral
    • C07K5/1005—Tetrapeptides with the first amino acid being neutral and aliphatic
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Abstract

A linear block copolymer comprising units of an alkylene oxide, linked to units of peptide via a linking group comprising a -CH2CHOHCH2N(R)- moiety, is useful as an imaging agent, drug, prodrug or as a delivery system for imaging agents, drugs or prodrugs.
PCT/GB1995/000418 1994-02-28 1995-02-28 Block copolymers WO1995022991A2 (en)

Priority Applications (4)

Application Number Priority Date Filing Date Title
JP7522220A JPH09509443A (en) 1994-02-28 1995-02-28 Block copolymer
MX9603680A MX9603680A (en) 1994-02-28 1995-02-28 Block copolymers.
EP95909864A EP0748226A1 (en) 1994-02-28 1995-02-28 Block copolymers
AU18170/95A AU1817095A (en) 1994-02-28 1995-02-28 Block copolymers

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US08/203,106 1994-02-28
US08/203,106 US5618528A (en) 1994-02-28 1994-02-28 Biologically compatible linear block copolymers of polyalkylene oxide and peptide units

Publications (2)

Publication Number Publication Date
WO1995022991A2 WO1995022991A2 (en) 1995-08-31
WO1995022991A3 true WO1995022991A3 (en) 1995-10-12

Family

ID=22752532

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/GB1995/000418 WO1995022991A2 (en) 1994-02-28 1995-02-28 Block copolymers

Country Status (8)

Country Link
US (2) US5618528A (en)
EP (1) EP0748226A1 (en)
JP (1) JPH09509443A (en)
CN (1) CN1146726A (en)
AU (1) AU1817095A (en)
CA (1) CA2183766A1 (en)
MX (1) MX9603680A (en)
WO (1) WO1995022991A2 (en)

Families Citing this family (72)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR100361933B1 (en) * 1993-09-08 2003-02-14 라 졸라 파마슈티칼 컴파니 Chemically defined nonpolymeric bonds form the platform molecule and its conjugate
PT648503E (en) * 1993-09-22 2000-11-30 Hoechst Ag PRO-PROFARMACOS, ITS PRODUCTION AND UTILIZATION
US6770261B2 (en) * 1995-06-02 2004-08-03 Research Corporation Technologies Magnetic resonance imaging agents for the detection of physiological agents
US20020064546A1 (en) * 1996-09-13 2002-05-30 J. Milton Harris Degradable poly(ethylene glycol) hydrogels with controlled half-life and precursors therefor
US6258351B1 (en) 1996-11-06 2001-07-10 Shearwater Corporation Delivery of poly(ethylene glycol)-modified molecules from degradable hydrogels
US20030215421A1 (en) * 1999-07-21 2003-11-20 Mcdonald John R. Methods and compositions for treating secondary tissue damage and other inflammatory conditions and disorders
US7157418B1 (en) 1998-07-22 2007-01-02 Osprey Pharmaceuticals, Ltd. Methods and compositions for treating secondary tissue damage and other inflammatory conditions and disorders
US6299860B1 (en) * 1998-10-15 2001-10-09 Fluoro Probe, Inc. Method for viewing diseased tissue located within a body cavity
US6652836B2 (en) 1998-10-15 2003-11-25 Fluoroprobe, Inc. Method for viewing tumor tissue located within a body cavity
US6458953B1 (en) * 1998-12-09 2002-10-01 La Jolla Pharmaceutical Company Valency platform molecules comprising carbamate linkages
CN1358171A (en) * 1999-06-08 2002-07-10 拉卓拉药物公司 Valency platform molecules comprising aminooxy groups
US6713454B1 (en) 1999-09-13 2004-03-30 Nobex Corporation Prodrugs of etoposide and etoposide analogs
AU2001227679A1 (en) * 2000-02-25 2001-09-03 General Atomics Mutant nucleic binding enzymes and use thereof in diagnostic, detection and purification methods
US6844318B2 (en) * 2000-03-15 2005-01-18 Bristol Myers Squibb Pharma Company Peptidase-cleavable, targeted antineoplastic drugs and their therapeutic use
WO2001071352A2 (en) * 2000-03-17 2001-09-27 The Salk Institute For Biological Studies Compositions associated with complex formation
US6610504B1 (en) 2000-04-10 2003-08-26 General Atomics Methods of determining SAM-dependent methyltransferase activity using a mutant SAH hydrolase
CN1434726A (en) 2000-06-08 2003-08-06 拉卓拉药物公司 Multivalent platform molecules comprising high molecular weight polyethylene oxide
EP1307216A4 (en) * 2000-07-12 2005-01-12 Gryphon Therapeutics Inc Polymer-modified bioactive synthetic chemokines, and methods for their manufacture and use
AU7338501A (en) * 2000-09-08 2002-03-22 Gryphon Sciences Polymer-modified synthetic proteins
US7118737B2 (en) * 2000-09-08 2006-10-10 Amylin Pharmaceuticals, Inc. Polymer-modified synthetic proteins
EP1333811A4 (en) * 2000-10-16 2004-03-03 Neopharm Inc Liposomal formulation of mitoxantrone
TWI246524B (en) 2001-01-19 2006-01-01 Shearwater Corp Multi-arm block copolymers as drug delivery vehicles
US7265186B2 (en) * 2001-01-19 2007-09-04 Nektar Therapeutics Al, Corporation Multi-arm block copolymers as drug delivery vehicles
GB0105929D0 (en) * 2001-03-09 2001-04-25 Btg Int Ltd Physiologically activated prodrugs
US20040077835A1 (en) * 2001-07-12 2004-04-22 Robin Offord Chemokine receptor modulators, production and use
WO2004061094A1 (en) 2002-12-30 2004-07-22 Gryphon Therapeutics, Inc. Water-soluble thioester and selenoester compounds and methods for making and using the same
AU2003300380B2 (en) * 2002-12-30 2008-11-06 Nektar Therapeutics Multi-arm polypeptide-poly(ethylene glycol) block copolymers as drug delivery vehicles
WO2004062588A2 (en) * 2003-01-06 2004-07-29 University Of Utah Water-soluble polymeric bone-targeting drug delivery system
US20050090804A1 (en) * 2003-10-22 2005-04-28 Trivascular, Inc. Endoluminal prosthesis endoleak management
FR2863619B1 (en) * 2003-12-11 2007-04-20 Oreal COPOLYMER ROD-COIL AND COSMETIC APPLICATION
US7354980B1 (en) 2004-03-12 2008-04-08 Key Medical Technologies, Inc. High refractive index polymers for ophthalmic applications
US7384760B2 (en) * 2004-04-30 2008-06-10 General Atomics Methods for assaying inhibitors of S-adenosylhomocysteine (SAH) hydrolase and S-adenosylmethionine (SAM)-dependent methyltransferase
WO2005115457A2 (en) * 2004-05-10 2005-12-08 University Of Utah Research Foundation Combined active and passive targeting of biologically active agents
US7446157B2 (en) 2004-12-07 2008-11-04 Key Medical Technologies, Inc. Nanohybrid polymers for ophthalmic applications
US20100092505A1 (en) 2005-04-05 2010-04-15 Elisabetta Bianchi Method for Shielding Functional Sites or Epitopes on Proteins
ATE524509T1 (en) * 2005-07-18 2011-09-15 Nektar Therapeutics BRANCHED FUNCTIONALIZED POLYMERS USING BRANCHED POLYOLS AS CORE
CN100365043C (en) * 2006-04-06 2008-01-30 北京理工大学 Synthesis of ABA polypeptide -b- polytetrahydrofuran-b-polypeptide triblock copolymer
US7985783B2 (en) 2006-09-21 2011-07-26 The Regents Of The University Of California Aldehyde tags, uses thereof in site-specific protein modification
EP3486653A1 (en) 2007-05-24 2019-05-22 The United States Government as represented by The Department of Veterans Affairs Treatment of skeletal muscle disorder using ent2
US8178617B2 (en) * 2007-07-16 2012-05-15 Allvivo Vascular, Inc. Antimicrobial constructs
EP2197340A4 (en) * 2007-09-19 2015-10-21 Oncofluor Inc Method for imaging and treating organs and tissues
JP5624027B2 (en) 2008-05-27 2014-11-12 ジェンザイム・コーポレーション Peptide analogues of α-melanocyte stimulating hormone
JP5580329B2 (en) 2008-12-05 2014-08-27 アブラクシス バイオサイエンス リミテッド ライアビリティー カンパニー SPARC binding peptides and uses thereof
US9155801B2 (en) 2009-05-28 2015-10-13 The United States Government As Represented By The Department Of Veterans Affairs Amino acid sequences which enhance peptide conjugate solubility
GB201012410D0 (en) 2010-07-23 2010-09-08 Medical Res Council Intracellular immunity
HUE029855T2 (en) 2011-07-05 2017-04-28 Bioasis Technologies Inc P97-antibody conjugates
GB201202268D0 (en) 2012-02-09 2012-03-28 Medical Res Council Intracellular immunity
US9532866B2 (en) * 2012-03-15 2017-01-03 L&C Bio Co., Ltd. Acellular dermal graft
CA2880162C (en) 2012-07-31 2023-04-04 Bioasis Technologies, Inc. Dephosphorylated lysosomal storage disease proteins and methods of use thereof
AU2013341711A1 (en) 2012-11-12 2015-05-21 Redwood Bioscience, Inc. Compounds and methods for producing a conjugate
WO2014078733A1 (en) 2012-11-16 2014-05-22 The Regents Of The University Of California Pictet-spengler ligation for protein chemical modification
US9310374B2 (en) 2012-11-16 2016-04-12 Redwood Bioscience, Inc. Hydrazinyl-indole compounds and methods for producing a conjugate
BR112015022416A2 (en) 2013-03-13 2017-10-24 Bioasis Technologies Inc p97 fragments and their uses
US20150093399A1 (en) 2013-08-28 2015-04-02 Bioasis Technologies, Inc. Cns-targeted conjugates having modified fc regions and methods of use thereof
CN105744935B (en) 2013-11-27 2022-09-30 雷德伍德生物科技股份有限公司 Hydrazino-pyrrolo compounds and methods for forming conjugates
EP3215537B1 (en) 2014-11-05 2022-01-05 Nanyang Technological University Stabilized and autonomous antibody vh domain
US11590242B2 (en) 2016-06-15 2023-02-28 Yale University Antibody-mediated autocatalytic, targeted delivery of nanocarriers to tumors
US20190330317A1 (en) 2016-06-15 2019-10-31 Yale University Anti-guanosine antibody as a molecular delivery vehicle
CN111094462A (en) 2017-12-26 2020-05-01 贝克顿·迪金森公司 Deep ultraviolet excitable water-solvated polymer dyes
US20210054102A1 (en) 2018-02-01 2021-02-25 Yale University Compositions and methods for enhancing nuclear translocation
CN112384573A (en) 2018-03-30 2021-02-19 贝克顿·迪金森公司 Water-soluble polymeric dyes containing pending chromophores
WO2020023300A1 (en) 2018-07-22 2020-01-30 Bioasis Technologies, Inc. Treatment of lymmphatic metastases
US20210355468A1 (en) 2020-05-18 2021-11-18 Bioasis Technologies, Inc. Compositions and methods for treating lewy body dementia
US20210393787A1 (en) 2020-06-17 2021-12-23 Bioasis Technologies, Inc. Compositions and methods for treating frontotemporal dementia
EP4182475A2 (en) 2020-07-17 2023-05-24 Onena Medicines S.L. Antibodies against lefty proteins
WO2023010060A2 (en) 2021-07-27 2023-02-02 Novab, Inc. Engineered vlrb antibodies with immune effector functions
EP4155349A1 (en) 2021-09-24 2023-03-29 Becton, Dickinson and Company Water-soluble yellow green absorbing dyes
WO2023056450A1 (en) 2021-09-30 2023-04-06 Yale University Compositions and methods for the treatment of autosomal dominant polycystic kidney disease and other diseases having upregulated mtor activity
WO2024007016A2 (en) 2022-07-01 2024-01-04 Beckman Coulter, Inc. Novel fluorescent dyes and polymers from dihydrophenanthrene derivatives
WO2024044327A1 (en) 2022-08-26 2024-02-29 Beckman Coulter, Inc. Dhnt monomers and polymer dyes with modified photophysical properties
WO2024050524A1 (en) 2022-09-01 2024-03-07 University Of Georgia Research Foundation, Inc. Compositions and methods for directing apolipoprotein l1 to induce mammalian cell death
WO2024064752A2 (en) 2022-09-20 2024-03-28 Yale University Compositions of wet adhesives derived from vibrio cholerae biofilm adhesins and methods thereof

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DD287949A5 (en) * 1989-09-15 1991-03-14 Adw Zi F. Molekularbiologie,De PROCESS FOR THE PRODUCTION OF COMPOUNDS WITH BIOLOGICAL ACTIVITY
WO1992000748A1 (en) * 1990-07-06 1992-01-23 Enzon, Inc. Poly(alkylene oxide) amino acid copolymers and drug carriers and charged copolymers based thereon
WO1993002712A1 (en) * 1991-08-01 1993-02-18 Danbiosyst Uk Limited Preparation of microparticles

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE1302066B (en) * 1963-06-10 1969-11-13 Avny Yair Method for grafting polypeptide chains onto polyhydroxy polymers
DE2433883C2 (en) * 1973-07-20 1986-03-27 Research Corp., New York, N.Y. Use of physiologically active polypeptides
US4179337A (en) * 1973-07-20 1979-12-18 Davis Frank F Non-immunogenic polypeptides

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DD287949A5 (en) * 1989-09-15 1991-03-14 Adw Zi F. Molekularbiologie,De PROCESS FOR THE PRODUCTION OF COMPOUNDS WITH BIOLOGICAL ACTIVITY
WO1992000748A1 (en) * 1990-07-06 1992-01-23 Enzon, Inc. Poly(alkylene oxide) amino acid copolymers and drug carriers and charged copolymers based thereon
WO1993002712A1 (en) * 1991-08-01 1993-02-18 Danbiosyst Uk Limited Preparation of microparticles

Non-Patent Citations (9)

* Cited by examiner, † Cited by third party
Title
DATABASE WPI Section Ch Week 9132, Derwent World Patents Index; Class A96, AN 91-230961 *
EFREMOVA NV ET AL: "Supramolecular structure based on protein conjugates with polyalkyleneoxides. Complexes with beta-cyclodextrin]", BIOKHIMIIA, JUL 1993, VOL. 58, NO. 7, PAGE(S) 1071-6 *
EFREMOVA, N. V. ET AL: "Conjugates of.alpha.-chymotrypsin with polyalkylene oxides", VESTN. MOSK. UNIV., SER. 2: KHIM., 1992, VOL. 33, NO. 6, PAGES 600-4 *
KIRILLOVA, G. P. ET AL: "The influence of pluronics and their conjugates with proteins on the rate of oxygen consumption by liver mitochondria and thymus lymphocytes", BIOTECHNOL. APPL. BIOCHEM., 1993,, vol. 18, no. 3, pages 329 - 339 *
RAPP, W. ET AL: "Comparative study of antibody titers induced by a peptide epitope conjugated with protein, lipopeptide, polyoxyethylene and polyoxyethylene-polystyrene graft copolymer", PEPT. 1990, PROC. EUR. PEPT. SYMP., 21ST, 1991, PAGES 849-50 *
TOPCHIEVA, I. N. ET AL: "The interaction of block copolymers of ethylene oxide and propylene oxide and their polymer-protein conjugates with lipids", BIOMED. SCI., 1991, VOL. 2, NO. 6, PAGES 562-8 *
TOUS G ET AL: "O'-(epoxyalkyl)tyrosines and (epoxyalkyl)phenylalanine as irreversible inactivators of serine proteases: synthesis and inhibition mechanism", J. MED. CHEM., 1990, VOL. 33, NO. 6, PAGE(S) 1620-34 *
YOKOYAMA M ET AL: "Preparation of micelle-forming polymer-drug conjugates", BIOCONJUG CHEM, JUL-AUG 1992, , VOL. 3, NO. 4, PAGE(S) 295-301, US *
YOKOYAMA M ET AL: "Stabilization of disulfide linkage in drug-polymer-immunoglobulin conjugate by microenvironmental control.", BIOCHEM BIOPHYS RES COMMUN, NOV 15 1989, , VOL. 164, NO. 3, PAGE(S) 1234-9, US *

Also Published As

Publication number Publication date
JPH09509443A (en) 1997-09-22
AU1817095A (en) 1995-09-11
EP0748226A1 (en) 1996-12-18
CN1146726A (en) 1997-04-02
WO1995022991A2 (en) 1995-08-31
US5853713A (en) 1998-12-29
MX9603680A (en) 1997-06-28
CA2183766A1 (en) 1995-08-31
US5618528A (en) 1997-04-08

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