WO1995026199A1 - Covalent dimers of kit ligand and flt-3/flk-2 ligand - Google Patents
Covalent dimers of kit ligand and flt-3/flk-2 ligand Download PDFInfo
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- WO1995026199A1 WO1995026199A1 PCT/US1995/003866 US9503866W WO9526199A1 WO 1995026199 A1 WO1995026199 A1 WO 1995026199A1 US 9503866 W US9503866 W US 9503866W WO 9526199 A1 WO9526199 A1 WO 9526199A1
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- 238000004255 ion exchange chromatography Methods 0.000 description 1
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- 229960000310 isoleucine Drugs 0.000 description 1
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- BPHPUYQFMNQIOC-NXRLNHOXSA-N isopropyl beta-D-thiogalactopyranoside Chemical compound CC(C)S[C@@H]1O[C@H](CO)[C@H](O)[C@H](O)[C@H]1O BPHPUYQFMNQIOC-NXRLNHOXSA-N 0.000 description 1
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- 210000000440 neutrophil Anatomy 0.000 description 1
- 230000003204 osmotic effect Effects 0.000 description 1
- YPZRWBKMTBYPTK-UHFFFAOYSA-N oxidized gamma-L-glutamyl-L-cysteinylglycine Natural products OC(=O)C(N)CCC(=O)NC(C(=O)NCC(O)=O)CSSCC(C(=O)NCC(O)=O)NC(=O)CCC(N)C(O)=O YPZRWBKMTBYPTK-UHFFFAOYSA-N 0.000 description 1
- 239000001301 oxygen Substances 0.000 description 1
- 229910052760 oxygen Inorganic materials 0.000 description 1
- 239000006174 pH buffer Substances 0.000 description 1
- 239000008194 pharmaceutical composition Substances 0.000 description 1
- 230000000144 pharmacologic effect Effects 0.000 description 1
- 239000013600 plasmid vector Substances 0.000 description 1
- 229920000642 polymer Polymers 0.000 description 1
- 230000035409 positive regulation of cell proliferation Effects 0.000 description 1
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- 238000006462 rearrangement reaction Methods 0.000 description 1
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- SQVRNKJHWKZAKO-OQPLDHBCSA-N sialic acid Chemical compound CC(=O)N[C@@H]1[C@@H](O)C[C@@](O)(C(O)=O)OC1[C@H](O)[C@H](O)CO SQVRNKJHWKZAKO-OQPLDHBCSA-N 0.000 description 1
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- 238000012868 site-directed mutagenesis technique Methods 0.000 description 1
- 239000011780 sodium chloride Substances 0.000 description 1
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- 239000000243 solution Substances 0.000 description 1
- 239000002904 solvent Substances 0.000 description 1
- 238000010561 standard procedure Methods 0.000 description 1
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- 239000000126 substance Substances 0.000 description 1
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- 238000002560 therapeutic procedure Methods 0.000 description 1
- 125000003396 thiol group Chemical group [H]S* 0.000 description 1
- 230000003582 thrombocytopenic effect Effects 0.000 description 1
- 230000001361 thrombopoietic effect Effects 0.000 description 1
- 229940104230 thymidine Drugs 0.000 description 1
- 238000004448 titration Methods 0.000 description 1
- 230000002103 transcriptional effect Effects 0.000 description 1
- 238000010361 transduction Methods 0.000 description 1
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- 230000032258 transport Effects 0.000 description 1
- QORWJWZARLRLPR-UHFFFAOYSA-H tricalcium bis(phosphate) Chemical compound [Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O QORWJWZARLRLPR-UHFFFAOYSA-H 0.000 description 1
- 230000001960 triggered effect Effects 0.000 description 1
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Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K19/00—Hybrid peptides, i.e. peptides covalently bound to nucleic acids, or non-covalently bound protein-protein complexes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/06—Antianaemics
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/475—Growth factors; Growth regulators
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Toxicology (AREA)
- Zoology (AREA)
- Gastroenterology & Hepatology (AREA)
- Hematology (AREA)
- Diabetes (AREA)
- Pulmonology (AREA)
- Immunology (AREA)
- Peptides Or Proteins (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
Description
Claims
Priority Applications (6)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP7525269A JPH09512706A (en) | 1994-03-28 | 1995-03-28 | Covalent dimers of Kit ligand and FLT-3 / FLK-2 ligand |
AU21998/95A AU2199895A (en) | 1994-03-28 | 1995-03-28 | Covalent dimers of kit ligand and flt-3/flk-2 ligand |
EP95914938A EP0759767A1 (en) | 1994-03-28 | 1995-03-28 | Covalent dimers of kit ligand and flt-3/flk-2 ligand |
MX9604394A MX9604394A (en) | 1994-03-28 | 1995-03-28 | Covalent dimers of kit ligand and flt-3/flk-2 ligand. |
NO964032A NO964032L (en) | 1994-03-28 | 1996-09-25 | Covalent dimers of kit ligand and FLT-3 / FLK-2 ligand |
FI963900A FI963900A (en) | 1994-03-28 | 1996-09-27 | Covalent dimers of a kit ligand and FLT-3 / FLK-2 ligand |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US08/220,379 | 1994-03-28 | ||
US08/220,379 US5525708A (en) | 1994-03-28 | 1994-03-28 | Covalent dimer of kit ligand |
Publications (1)
Publication Number | Publication Date |
---|---|
WO1995026199A1 true WO1995026199A1 (en) | 1995-10-05 |
Family
ID=22823324
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/US1995/003866 WO1995026199A1 (en) | 1994-03-28 | 1995-03-28 | Covalent dimers of kit ligand and flt-3/flk-2 ligand |
Country Status (10)
Country | Link |
---|---|
US (1) | US5525708A (en) |
EP (1) | EP0759767A1 (en) |
JP (1) | JPH09512706A (en) |
AU (1) | AU2199895A (en) |
CA (1) | CA2186496A1 (en) |
FI (1) | FI963900A (en) |
HU (1) | HU9602682D0 (en) |
MX (1) | MX9604394A (en) |
NO (1) | NO964032L (en) |
WO (1) | WO1995026199A1 (en) |
Cited By (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1998046750A1 (en) * | 1997-04-11 | 1998-10-22 | G.D. Searle & Co. | flt3 LIGAND CHIMERIC PROTEINS |
US5885962A (en) * | 1996-04-05 | 1999-03-23 | Amgen Inc. | Stem cell factor analog compositions and method |
US8093046B2 (en) * | 2006-05-31 | 2012-01-10 | Philadelphia Health and Education Corporation d/b/c Drexel University College of Medicine | CVN-12p1: a recombinant allosteric lectin antagonist of HIV-1 envelope gp120 interactions |
US8524655B2 (en) | 2004-11-05 | 2013-09-03 | Northwestern University | Use of SCF and G-CSF in the treatment of cerebral ischemia and neurological disorders |
Families Citing this family (12)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CZ307995A3 (en) | 1993-05-24 | 1996-10-16 | Immunex Corp | Ligands for flt3 receptors |
US5554512A (en) * | 1993-05-24 | 1996-09-10 | Immunex Corporation | Ligands for flt3 receptors |
US6190655B1 (en) | 1993-12-03 | 2001-02-20 | Immunex Corporation | Methods of using Flt-3 ligand for exogenous gene transfer |
US7294331B2 (en) * | 1994-03-07 | 2007-11-13 | Immunex Corporation | Methods of using flt3-ligand in hematopoietic cell transplantation |
US7150992B1 (en) | 1995-10-04 | 2006-12-19 | Innunex Corporation | Methods of preparing dendritic cells with flt3-ligand and antigen |
US20020034517A1 (en) * | 1995-10-04 | 2002-03-21 | Kenneth Brasel | Dendritic cell stimulatory factor |
US7361330B2 (en) * | 1995-10-04 | 2008-04-22 | Immunex Corporation | Methods of using flt3-ligand in the treatment of fibrosarcoma |
US6017527A (en) * | 1996-07-10 | 2000-01-25 | Immunex Corporation | Activated dendritic cells and methods for their activation |
EP0961824A4 (en) * | 1996-07-10 | 2003-01-29 | Immunex Corp | Method of activating dendritic cells |
US20030022233A1 (en) | 1999-04-30 | 2003-01-30 | Raymond G. Goodwin | Methods of use of the taci/taci-l interaction |
US20030077263A1 (en) * | 1999-10-29 | 2003-04-24 | Immunex Corporation | Method of activating dendritic cells |
NZ597580A (en) * | 2009-07-20 | 2013-11-29 | Univ Nat Taiwan | Polypeptides selective for alpha.v.beta.3 integrin conjugated with a variant of human serum albumin (hsa) and pharmaceutical uses thereof |
Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1991005795A1 (en) * | 1989-10-16 | 1991-05-02 | Amgen Inc. | Stem cell factor |
WO1994028391A1 (en) * | 1993-05-24 | 1994-12-08 | Immunex Corporation | Ligands for flt3 receptors |
Family Cites Families (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4873191A (en) * | 1981-06-12 | 1989-10-10 | Ohio University | Genetic transformation of zygotes |
EP0676470A1 (en) * | 1989-10-16 | 1995-10-11 | Amgen Inc. | Stem cell factor |
WO1992000376A1 (en) * | 1990-06-25 | 1992-01-09 | Immunex Corporation | Mast cell growth factor |
US20030125519A1 (en) * | 1990-08-27 | 2003-07-03 | Peter Besmer | Ligand for the c-kit receptor and methods of use thereof |
US5199942A (en) * | 1991-06-07 | 1993-04-06 | Immunex Corporation | Method for improving autologous transplantation |
WO1993005795A1 (en) * | 1991-09-13 | 1993-04-01 | Boron Biologicals, Inc. | Method of combatting osteoporosis and other disease states in mammalian subjects, utilizing organic boron compounds |
HU219540B (en) * | 1992-04-23 | 2001-05-28 | Sloan-Kettering Institute For Cancer Research | Ligand for the c-kit receptor and methods of use thereof |
-
1994
- 1994-03-28 US US08/220,379 patent/US5525708A/en not_active Expired - Lifetime
-
1995
- 1995-03-28 JP JP7525269A patent/JPH09512706A/en not_active Ceased
- 1995-03-28 EP EP95914938A patent/EP0759767A1/en not_active Withdrawn
- 1995-03-28 AU AU21998/95A patent/AU2199895A/en not_active Abandoned
- 1995-03-28 WO PCT/US1995/003866 patent/WO1995026199A1/en not_active Application Discontinuation
- 1995-03-28 MX MX9604394A patent/MX9604394A/en not_active IP Right Cessation
- 1995-03-28 HU HU9602682A patent/HU9602682D0/en unknown
- 1995-03-28 CA CA002186496A patent/CA2186496A1/en not_active Abandoned
-
1996
- 1996-09-25 NO NO964032A patent/NO964032L/en unknown
- 1996-09-27 FI FI963900A patent/FI963900A/en not_active Application Discontinuation
Patent Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1991005795A1 (en) * | 1989-10-16 | 1991-05-02 | Amgen Inc. | Stem cell factor |
WO1994028391A1 (en) * | 1993-05-24 | 1994-12-08 | Immunex Corporation | Ligands for flt3 receptors |
Cited By (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5885962A (en) * | 1996-04-05 | 1999-03-23 | Amgen Inc. | Stem cell factor analog compositions and method |
WO1998046750A1 (en) * | 1997-04-11 | 1998-10-22 | G.D. Searle & Co. | flt3 LIGAND CHIMERIC PROTEINS |
US8524655B2 (en) | 2004-11-05 | 2013-09-03 | Northwestern University | Use of SCF and G-CSF in the treatment of cerebral ischemia and neurological disorders |
US8093046B2 (en) * | 2006-05-31 | 2012-01-10 | Philadelphia Health and Education Corporation d/b/c Drexel University College of Medicine | CVN-12p1: a recombinant allosteric lectin antagonist of HIV-1 envelope gp120 interactions |
Also Published As
Publication number | Publication date |
---|---|
NO964032L (en) | 1996-11-28 |
AU2199895A (en) | 1995-10-17 |
EP0759767A1 (en) | 1997-03-05 |
HU9602682D0 (en) | 1996-11-28 |
CA2186496A1 (en) | 1995-10-05 |
MX9604394A (en) | 1997-07-31 |
NO964032D0 (en) | 1996-09-25 |
FI963900A0 (en) | 1996-09-27 |
JPH09512706A (en) | 1997-12-22 |
FI963900A (en) | 1996-11-27 |
US5525708A (en) | 1996-06-11 |
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