WO1995027041A1 - Culture media additives for bioreactors - Google Patents

Culture media additives for bioreactors Download PDF

Info

Publication number
WO1995027041A1
WO1995027041A1 PCT/US1994/008295 US9408295W WO9527041A1 WO 1995027041 A1 WO1995027041 A1 WO 1995027041A1 US 9408295 W US9408295 W US 9408295W WO 9527041 A1 WO9527041 A1 WO 9527041A1
Authority
WO
WIPO (PCT)
Prior art keywords
bioreactors
culture media
media additives
hollow fiber
culture medium
Prior art date
Application number
PCT/US1994/008295
Other languages
French (fr)
Inventor
Randal A. Goffe
Original Assignee
Unisyn Technologies, Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Unisyn Technologies, Inc. filed Critical Unisyn Technologies, Inc.
Priority to EP94922694A priority Critical patent/EP0711339A1/en
Priority to AU73713/94A priority patent/AU7371394A/en
Priority to JP7525645A priority patent/JPH08511173A/en
Publication of WO1995027041A1 publication Critical patent/WO1995027041A1/en
Priority to NO954854A priority patent/NO954854D0/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/0018—Culture media for cell or tissue culture
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2500/00—Specific components of cell culture medium
    • C12N2500/05—Inorganic components
    • C12N2500/10—Metals; Metal chelators
    • C12N2500/20—Transition metals
    • C12N2500/24—Iron; Fe chelators; Transferrin
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/999—Small molecules not provided for elsewhere

Abstract

A hollow fiber bioreactor culture medium which contains a stabilized hemoglobin or a perfluorochemical emulsion is described. The culture medium mediates oxygen demand and utilization. Efficiency of the bioreactor is enhanced so that novel hollow fiber and stirred tank cell culture system configurations, equipment and methods are enabled.
PCT/US1994/008295 1994-04-01 1994-07-26 Culture media additives for bioreactors WO1995027041A1 (en)

Priority Applications (4)

Application Number Priority Date Filing Date Title
EP94922694A EP0711339A1 (en) 1994-04-01 1994-07-26 Culture media additives for bioreactors
AU73713/94A AU7371394A (en) 1994-04-01 1994-07-26 Culture media additives for bioreactors
JP7525645A JPH08511173A (en) 1994-04-01 1994-07-26 Culture medium additives for bioreactors
NO954854A NO954854D0 (en) 1994-04-01 1995-11-29 Culture media additives for bioreactors

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
PCT/US1994/003613 WO1995027040A1 (en) 1994-04-01 1994-04-01 Culture media additives for hollow fiber bioreactors
USPCT/US94/03613 1994-04-01

Publications (1)

Publication Number Publication Date
WO1995027041A1 true WO1995027041A1 (en) 1995-10-12

Family

ID=22242416

Family Applications (2)

Application Number Title Priority Date Filing Date
PCT/US1994/003613 WO1995027040A1 (en) 1994-04-01 1994-04-01 Culture media additives for hollow fiber bioreactors
PCT/US1994/008295 WO1995027041A1 (en) 1994-04-01 1994-07-26 Culture media additives for bioreactors

Family Applications Before (1)

Application Number Title Priority Date Filing Date
PCT/US1994/003613 WO1995027040A1 (en) 1994-04-01 1994-04-01 Culture media additives for hollow fiber bioreactors

Country Status (6)

Country Link
EP (1) EP0711339A1 (en)
JP (1) JPH08511173A (en)
AU (2) AU6766994A (en)
CA (1) CA2163618A1 (en)
NO (1) NO954854D0 (en)
WO (2) WO1995027040A1 (en)

Cited By (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2001023520A1 (en) * 1999-09-30 2001-04-05 Unisearch Limited Method and apparatus for culturing cells
WO2002022775A1 (en) * 2000-09-13 2002-03-21 Csir Bio-reactor device
AU781265B2 (en) * 1999-09-30 2005-05-12 Unisearch Limited Method and apparatus for culturing cells
WO2010122080A1 (en) * 2009-04-23 2010-10-28 Hemarina Bioreactor using oxygen-carrying molecules
US20120052136A1 (en) * 2009-05-07 2012-03-01 Hemarina Novel heamoglobin and uses thereof
US9677042B2 (en) 2010-10-08 2017-06-13 Terumo Bct, Inc. Customizable methods and systems of growing and harvesting cells in a hollow fiber bioreactor system
US11624046B2 (en) 2017-03-31 2023-04-11 Terumo Bct, Inc. Cell expansion
US11629332B2 (en) 2017-03-31 2023-04-18 Terumo Bct, Inc. Cell expansion
US11667881B2 (en) 2014-09-26 2023-06-06 Terumo Bct, Inc. Scheduled feed

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6255109B1 (en) 1998-06-24 2001-07-03 Board Of Supervisors Of Louisiana State University And Agricultural And Mechanical College Nitric oxide-scavenging system for culturing oocytes, embryos, or other cells
GB9915413D0 (en) * 1999-07-01 1999-09-01 Glaxo Group Ltd Propagation method
DE10136912A1 (en) * 2001-07-30 2003-02-20 Wolfgang Fege Providing oxygen to cell or tissue cultures, useful e.g. for growing organs for transplantation, comprises using substances that bind oxygen reversibly
WO2007139791A2 (en) 2006-05-22 2007-12-06 The Regents Of The University Of California Compositions and methods for the delivery of oxygen

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3997396A (en) * 1973-07-02 1976-12-14 Monsanto Company Method for the in vitro propagation and maintenance of cells
US5223428A (en) * 1982-12-14 1993-06-29 Baxter International Inc. Method for in vitro culture of mammalian cells
US5264555A (en) * 1992-07-14 1993-11-23 Enzon, Inc. Process for hemoglobin extraction and purification

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5180676A (en) * 1984-06-14 1993-01-19 Teijin Limited Method of cultivating animal or plant cells
EP0260627B1 (en) * 1986-09-19 1993-06-16 Shimadzu Corporation Pressure incubator
EP0283942B1 (en) * 1987-03-24 1992-05-20 W.R. Grace & Co.-Conn. Basal nutrient medium for cell culture

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3997396A (en) * 1973-07-02 1976-12-14 Monsanto Company Method for the in vitro propagation and maintenance of cells
US5223428A (en) * 1982-12-14 1993-06-29 Baxter International Inc. Method for in vitro culture of mammalian cells
US5264555A (en) * 1992-07-14 1993-11-23 Enzon, Inc. Process for hemoglobin extraction and purification

Cited By (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2001023520A1 (en) * 1999-09-30 2001-04-05 Unisearch Limited Method and apparatus for culturing cells
AU781265B2 (en) * 1999-09-30 2005-05-12 Unisearch Limited Method and apparatus for culturing cells
WO2002022775A1 (en) * 2000-09-13 2002-03-21 Csir Bio-reactor device
FR2814468A1 (en) * 2000-09-13 2002-03-29 Csir DEVICE AS BIOREACTOR
NL1018942C2 (en) * 2000-09-13 2002-07-02 Csir Bioreactor.
US7129082B2 (en) 2000-09-13 2006-10-31 Csir Bio-reactor device
US10119110B2 (en) 2009-04-23 2018-11-06 Hemarina Bioreactor using oxygen-carrying molecules
WO2010122080A1 (en) * 2009-04-23 2010-10-28 Hemarina Bioreactor using oxygen-carrying molecules
US11224218B2 (en) * 2009-05-07 2022-01-18 Hemarina Heamoglobin and uses thereof
US20120052136A1 (en) * 2009-05-07 2012-03-01 Hemarina Novel heamoglobin and uses thereof
US9725689B2 (en) 2010-10-08 2017-08-08 Terumo Bct, Inc. Configurable methods and systems of growing and harvesting cells in a hollow fiber bioreactor system
US9677042B2 (en) 2010-10-08 2017-06-13 Terumo Bct, Inc. Customizable methods and systems of growing and harvesting cells in a hollow fiber bioreactor system
US10669519B2 (en) 2010-10-08 2020-06-02 Terumo Bct, Inc. Customizable methods and systems of growing and harvesting cells in a hollow fiber bioreactor system
US10870827B2 (en) 2010-10-08 2020-12-22 Terumo Bct, Inc. Configurable methods and systems of growing and harvesting cells in a hollow fiber bioreactor system
US11613727B2 (en) 2010-10-08 2023-03-28 Terumo Bct, Inc. Configurable methods and systems of growing and harvesting cells in a hollow fiber bioreactor system
US11746319B2 (en) 2010-10-08 2023-09-05 Terumo Bct, Inc. Customizable methods and systems of growing and harvesting cells in a hollow fiber bioreactor system
US11773363B2 (en) 2010-10-08 2023-10-03 Terumo Bct, Inc. Configurable methods and systems of growing and harvesting cells in a hollow fiber bioreactor system
US11667881B2 (en) 2014-09-26 2023-06-06 Terumo Bct, Inc. Scheduled feed
US11624046B2 (en) 2017-03-31 2023-04-11 Terumo Bct, Inc. Cell expansion
US11629332B2 (en) 2017-03-31 2023-04-18 Terumo Bct, Inc. Cell expansion
US11702634B2 (en) 2017-03-31 2023-07-18 Terumo Bct, Inc. Expanding cells in a bioreactor

Also Published As

Publication number Publication date
NO954854L (en) 1995-11-29
AU6766994A (en) 1995-10-23
EP0711339A1 (en) 1996-05-15
JPH08511173A (en) 1996-11-26
AU7371394A (en) 1995-10-23
NO954854D0 (en) 1995-11-29
WO1995027040A1 (en) 1995-10-12
CA2163618A1 (en) 1995-10-12

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