WO1996003165A1 - Prostheses for the abdominal wall - Google Patents

Prostheses for the abdominal wall Download PDF

Info

Publication number
WO1996003165A1
WO1996003165A1 PCT/GB1995/001715 GB9501715W WO9603165A1 WO 1996003165 A1 WO1996003165 A1 WO 1996003165A1 GB 9501715 W GB9501715 W GB 9501715W WO 9603165 A1 WO9603165 A1 WO 9603165A1
Authority
WO
WIPO (PCT)
Prior art keywords
prosthesis
antimicrobial agent
retaining
resorbable
gel
Prior art date
Application number
PCT/GB1995/001715
Other languages
French (fr)
Inventor
Roshan Maini
Timothy Rawden Ashton
Original Assignee
Vascutek Limited
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Vascutek Limited filed Critical Vascutek Limited
Priority to EP95925930A priority Critical patent/EP0772468A1/en
Priority to JP8505567A priority patent/JPH10503099A/en
Priority to AU29872/95A priority patent/AU2987295A/en
Publication of WO1996003165A1 publication Critical patent/WO1996003165A1/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
    • A61L31/14—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A61L31/16—Biologically active materials, e.g. therapeutic substances
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/0063—Implantable repair or support meshes, e.g. hernia meshes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
    • A61L2300/404—Biocides, antimicrobial agents, antiseptic agents

Definitions

  • This invention relates to prosthetic material for the repair of the abdominal wall in the case of injury or lesion caused, for example, by hernia, invasive infection or trauma.
  • the invention also encompasses prostheses made from such material.
  • the invention addresses the general problem of providing prosthetic material for abdominal wall reconstruction.
  • PTFE polytetrafluoroethylene
  • GORE-TEX soft tissue patch and macroporous polypropylene mesh (particularly as sold as MARLEX ) have been used as prosthetic materials for abdominal wall reconstruction.
  • Brown et al . (Ann. Surgery 201(6) 705-711 (1985)) experimentally compared PTFE and polypropylene mesh abdominal wall prostheses and found a slight preference for the PTFE material.
  • Antibiotics were administered systemically in these experiments. In spite of the prior work that has been carried out in this area, there remains a low but significant rate of infection associated with synthetic tissue patches for abdominal wall reconstruction.
  • an abdominal wall prosthesis which is capable of retaining and delivering, an antimicrobial agent.
  • the prosthesis may comprise a composite structure of a resorbable porous material which absorbs and retains the microbiological agent.
  • the composite may further comprise a non-resorbable mesh capable for use in abdominal wall reconstruction.
  • Goeau-Brissonniere et al. (Ann. Vaac. Surgery 5(5) 408- 412 (1991) ) used protein-impregnated porous materials containing rifampin as a vascular graft. In that case, the purpose of the protein-impregnation was to completely seal the graft, rather than specifically to provide a matrix for the rifampin. Graft sealing is not a requirement of abdominal wall prostheses, so the prior publication of Goeau-Brissonniere et al. does little to address the problem addressed by the present invention.
  • the porous material of this invention preferably comprises a substrate which is impregnated or otherwise associated with a suitable substance capable of retaining the antimicrobial agent.
  • the substance capable of retaining an antimicrobial agent will not be a separate foil or film. Instead, the substance capable of retaining an antimicrobial agent impregnates the interstices of the substrate to form a composite prosthetic structure.
  • the substance capable of retaining an antimicrobial agent will be completely resorbable in nature and the substrate will be either of synthetic or natural origin and will be non- resorbable once implanted into the patient.
  • the substrate itself may be macroporous or microporous membrane, mesh or fabric. If a fabric, the fabric may be non-woven, woven, or preferably knitted.
  • the fibre from which the fabric is prepared may be polymeric, for example PTFE, polypropylene or polyester, particularly polyethyleneterephthalate (PET) .
  • the substance capable of retaining the antimicrobial agent may be a gel or have a gel-like or sponge-like open structure.
  • the substance is proteinaceous.
  • the protein may be any suitable material having the desired properties for its intended use.
  • the protein is gelatin (which is within the meaning of the term "protein” as it is used in this specification) , ideally partially cross-linked as described in EP-A- 0183365.
  • the protein may also be a polyglycollic acid gel or other synthetic absorbable gel.
  • a suitable and highly desirable protein-impregnated porous material is available from Vascutek Limited under the trade mark GELSEAL.
  • the resorbable gelatin and the membrane mesh or fabric substrate be of a composite construction.
  • Figures 1 and 2 the advantage of using a composite construction is clearly demonstrated. Specifically, in Figure 1, a non-composite, non-impregnated abdominal wall prothesis is shown. As demonstrated the antibiotic is forced to diffuse a great distance in order to surround and protect the mesh. During this diffusion process, antibiotic is lost and therefore lower concentrations of the antimicrobial agents is present at the site of prosthesis insertion. In the composite structure as shown in Figure 2, the antibiotic completely surrounds, the membrane, mesh or fabric due to the interlocking (impregnated) nature of the resorbable gelatin and the non-resorbable membrane, mesh or fabric. This allows the gelatin to completely envelope the substrate and dispense a high antimicrobial concentration around and into the mesh.
  • the antimicrobial agent of this invention may be an antiviral, an antibacterial, an antifungal or an antiprotozoal.
  • Antibacterials include natural and semi- synthetic antibiotics as well as wholly synthetic antibacterials.
  • Rifampin is an antibacterial which may be used to advantage in the present invention. Mixtures of different antimicrobial agents may be used. Sufficient antimicrobial agent will be present to provide an antimicrobial-effective dose of the agent in the conditions of use.
  • the porous material contains the antimicrobial agent.
  • the antimicrobial agent may be absorbed in or adsorbed on the substrate, or even chemically bound to it in some convenient way, providing that its efficacy is not impaired.
  • Prostheses in accordance with the invention may be prepared by the following process, which itself forms part of the invention.
  • a process for the preparation of a prosthesis as described above comprising loading the porous material with antimicrobial agent.
  • the anti ⁇ microbial agent may be supplied in liquid form; if a solid at room temperature, it may be provided in the form of a solution, for example in water or normal saline. In such a case, loading will conveniently be achieved by contacting the porous material with the antimicrobial agent in liquid form, for example by spraying or, preferably, immersion.
  • the gelatin-sealed knitted polyester graft available under the trade mark GE SOFT from Vascutek Limited may be soaked just before use in a lmg/ml normal saline solution of rifampin at 37°C for 15 minutes. This is not to suggest that these conditions are limiting, but rather they are illustrative of the concentration and conditions that may be used to achieve a suitable loading.
  • the porous material itself may be prepared in any suitable way, for example as indicated in EP-A-0183365.
  • prostheses in accordance with the invention is to reconstruct the abdominal wall of humans or, if required, other animals.
  • the invention is therefore expected to be useful in a method of reconstructing the abdominal wall, the method comprising suturing or otherwise connecting a prostheses as described above to the abdominal wall margin.
  • an antimicrobial agent in the preparation of a prosthesis for the abdominal wall.
  • Prosthesis material which may be porous, will generally also be used in the preparation.
  • Gelatin-sealed knitted polyester graft patches were prepared in accordance with EP-A-0183365 and were soaked in a lmg/ml normal saline solution of rifampin (RIFADINE ) at 37°C for 15 minutes.
  • RFADINE rifampin
  • Circular patches 2 cm in diameter containing Rifampicin are implanted subcutaneously in rabbits.
  • the patches were either gelatin impregnated mesh (Gel+) or mesh only

Abstract

To reduce the risk of infection in the reconstruction of the abdominal wall following hernia or other injury, a prosthesis comprises a porous material containing an antibacterial and/or other antimicrobial agent. The porous material preferably comprises a knitted polyester non-resorbable membrane, mesh or fabric substrate impregnated or enveloped with partially cross-linked (resorbable) gelatin and can be loaded with antimicrobial by soaking prior to suturing to the abdominal wall margin.

Description

PROSTHESES FOR THE ABDOMINAL WALL
This invention relates to prosthetic material for the repair of the abdominal wall in the case of injury or lesion caused, for example, by hernia, invasive infection or trauma. The invention also encompasses prostheses made from such material.
The invention addresses the general problem of providing prosthetic material for abdominal wall reconstruction.
Contamination and infection are common problems encountered by surgeons in reconstructing the abdominal wall; these problems are exacerbated when foreign
(usually synthetic) materials are present in a prosthesis, in that the risk of intraoperative contamination rises. Elek et al . (Br. J. Exp . Pathol . 38
573-579 (1957)) showed that, when foreign materials are present, fewer microorganisms are required to produce a clinical infection: the foreign material acts as an adjuvant by decreasing the number of bacteria or other organisms necessary to produce an infection.
Both microporous polytetrafluoroethylene (PTFE) , particularly as sold as the GORE-TEX soft tissue patch and macroporous polypropylene mesh (particularly as sold as MARLEX ) have been used as prosthetic materials for abdominal wall reconstruction. Brown et al . (Ann. Surgery 201(6) 705-711 (1985)) experimentally compared PTFE and polypropylene mesh abdominal wall prostheses and found a slight preference for the PTFE material. Antibiotics were administered systemically in these experiments. In spite of the prior work that has been carried out in this area, there remains a low but significant rate of infection associated with synthetic tissue patches for abdominal wall reconstruction.
It has now been found that materials adapted to retain and deliver an antibiotic or other antimicrobial agent can also be used as abdominal wall prostheses.
According to a first aspect of the present invention, there is provided an abdominal wall prosthesis which is capable of retaining and delivering, an antimicrobial agent.
The prosthesis may comprise a composite structure of a resorbable porous material which absorbs and retains the microbiological agent. The composite may further comprise a non-resorbable mesh capable for use in abdominal wall reconstruction.
Goeau-Brissonniere et al. (Ann. Vaac. Surgery 5(5) 408- 412 (1991) ) used protein-impregnated porous materials containing rifampin as a vascular graft. In that case, the purpose of the protein-impregnation was to completely seal the graft, rather than specifically to provide a matrix for the rifampin. Graft sealing is not a requirement of abdominal wall prostheses, so the prior publication of Goeau-Brissonniere et al. does little to address the problem addressed by the present invention.
The porous material of this invention preferably comprises a substrate which is impregnated or otherwise associated with a suitable substance capable of retaining the antimicrobial agent. Preferably, the substance capable of retaining an antimicrobial agent will not be a separate foil or film. Instead, the substance capable of retaining an antimicrobial agent impregnates the interstices of the substrate to form a composite prosthetic structure. Most preferably, the substance capable of retaining an antimicrobial agent will be completely resorbable in nature and the substrate will be either of synthetic or natural origin and will be non- resorbable once implanted into the patient. The substrate itself may be macroporous or microporous membrane, mesh or fabric. If a fabric, the fabric may be non-woven, woven, or preferably knitted. The fibre from which the fabric is prepared may be polymeric, for example PTFE, polypropylene or polyester, particularly polyethyleneterephthalate (PET) .
The substance capable of retaining the antimicrobial agent may be a gel or have a gel-like or sponge-like open structure. In preferred embodiments of the invention, the substance is proteinaceous. The protein may be any suitable material having the desired properties for its intended use. In particularly preferred embodiments, the protein is gelatin (which is within the meaning of the term "protein" as it is used in this specification) , ideally partially cross-linked as described in EP-A- 0183365. The protein may also be a polyglycollic acid gel or other synthetic absorbable gel. A suitable and highly desirable protein-impregnated porous material is available from Vascutek Limited under the trade mark GELSEAL.
As stated above, it is also a preferred embodiment of the invention that the resorbable gelatin and the membrane mesh or fabric substrate be of a composite construction. In Figures 1 and 2, the advantage of using a composite construction is clearly demonstrated. Specifically, in Figure 1, a non-composite, non-impregnated abdominal wall prothesis is shown. As demonstrated the antibiotic is forced to diffuse a great distance in order to surround and protect the mesh. During this diffusion process, antibiotic is lost and therefore lower concentrations of the antimicrobial agents is present at the site of prosthesis insertion. In the composite structure as shown in Figure 2, the antibiotic completely surrounds, the membrane, mesh or fabric due to the interlocking (impregnated) nature of the resorbable gelatin and the non-resorbable membrane, mesh or fabric. This allows the gelatin to completely envelope the substrate and dispense a high antimicrobial concentration around and into the mesh.
A significant advantage gained by utilising a composite of resorbable gelatin and a non-resorbable mesh as disclosed in this invention, is that the strength for the prosthesis will be provided by the non-resorbable membrane, mesh or fabric while the resorbable gelatin containing the antimicrobial agent will be resorbed by the patient, allowing for good tissue penetration into the mesh and hence a more secure prothesis.
There have been several prior attempts to construct a prosthesis or a net for implantation which includes treatment with some form of antibiotic. For instance, in US Patent No. 4,329,185 of Dimov et al. a biologically active polyamide net designed for implantation in the human body is prepared by a series of washing steps, one of which includes soaking the net in antibiotic and then rinsing and drying the net to a desired residual humidity level. The net described, however, is not of a composite nature and hence the prolonged presence of antibiotic is not achieved. In Jenkins et al., Surgery 94 392-398 (1983) , synthetic protheses were tested for their abilities to maintain strength, to be incorporated by surrounding tissues and to not stimulate adhesions. Whereas use of a variety of mesh was discussed, no mention of antimicrobial agents or a process by which the antimicrobials could be supplied to a prothesis prior to implant is mentioned. Additionally, an absorbable gelatin film in association with Marlex mesh was used as a separate film and not as an integral part of a composite Marlex/gelatin structure as seen in the present invention. The purpose of the separate gelatin film in the aforementioned publication was to prevent adhesions.
The antimicrobial agent of this invention may be an antiviral, an antibacterial, an antifungal or an antiprotozoal. Antibacterials include natural and semi- synthetic antibiotics as well as wholly synthetic antibacterials. Rifampin is an antibacterial which may be used to advantage in the present invention. Mixtures of different antimicrobial agents may be used. Sufficient antimicrobial agent will be present to provide an antimicrobial-effective dose of the agent in the conditions of use.
The porous material contains the antimicrobial agent. The antimicrobial agent may be absorbed in or adsorbed on the substrate, or even chemically bound to it in some convenient way, providing that its efficacy is not impaired. Prostheses in accordance with the invention may be prepared by the following process, which itself forms part of the invention.
According to a second aspect of the invention, there is provided a process for the preparation of a prosthesis as described above, the process comprising loading the porous material with antimicrobial agent. The anti¬ microbial agent may be supplied in liquid form; if a solid at room temperature, it may be provided in the form of a solution, for example in water or normal saline. In such a case, loading will conveniently be achieved by contacting the porous material with the antimicrobial agent in liquid form, for example by spraying or, preferably, immersion.
By way of example, the gelatin-sealed knitted polyester graft available under the trade mark GE SOFT from Vascutek Limited may be soaked just before use in a lmg/ml normal saline solution of rifampin at 37°C for 15 minutes. This is not to suggest that these conditions are limiting, but rather they are illustrative of the concentration and conditions that may be used to achieve a suitable loading.
The porous material itself may be prepared in any suitable way, for example as indicated in EP-A-0183365.
The principal intended use of prostheses in accordance with the invention is to reconstruct the abdominal wall of humans or, if required, other animals. The invention is therefore expected to be useful in a method of reconstructing the abdominal wall, the method comprising suturing or otherwise connecting a prostheses as described above to the abdominal wall margin. According to a third aspect of the present invention, there is provided the use of an antimicrobial agent in the preparation of a prosthesis for the abdominal wall. Prosthesis material, which may be porous, will generally also be used in the preparation.
Preferred features of each aspect of the invention are for each other aspect, mutatis mutandis.
The invention will now be described by the following non- limiting example.
EXAMPLE
Gelatin-sealed knitted polyester graft patches were prepared in accordance with EP-A-0183365 and were soaked in a lmg/ml normal saline solution of rifampin (RIFADINE ) at 37°C for 15 minutes.
Circular patches 2 cm in diameter containing Rifampicin are implanted subcutaneously in rabbits. The patches were either gelatin impregnated mesh (Gel+) or mesh only
(Gel-) (i.e. composite resorbable/non-resorbable patches vs. non-composite non-resorbable patches) . The patches were soaked in 20 mg/ml Rifampicin solution for 10 minutes. After the 10 minute soaking, the composite implants containing gelatin contained 740 μg/ταl of rifampicin and the non-composite circular patches without gelatin (Gel-) contained only 490 μg/ml rifampicin. The patches were then surgically implanted into the rabbits and then explanted at varying time intervals and the remaining antibiotic then assayed. From Table I below, it can be seen that at 24 hours, 48 hours and 96 hours post-implantation, the mean loading of antibiotic was higher in the composite gelatin impregnated patches. TABLE I
Rabbit 01 Rabbit 02 Rabbit 03 Mean
H Gel+ 1,25 Gel+ 1,54 Gel+ 0,8 1,2 ± 0,37
Gel- 0,32 Gel- 0,68 Gel- 0,23 0,41 ± 0,2 H Gel+ 0,14 Gel+ 0,22 Gel+ 0,25 0,2 ± 0,05
Gel- 0,15 Gel- 0,15 Gel- 0,09 0,13 ± 0,0 H Gel+ 0,14 Gel+ 0,21 Gel+ 0,09 0,15 ± 0,0
Gel- 0,07 Gel- <0,07 Gel- 0,07 0,07

Claims

1. An abdominal wall prosthesis capable of retaining and delivering an antimicrobial agent.
2. A prosthesis as claimed in claim 1, which comprises a porous material containing an antimicrobial agent.
3. A prosthesis as claimed in claim 2, in which the porous material comprises a substrate which is impregnated or otherwise associated with a suitable substance capable of retaining an antimicrobial agent.
4. A prosthesis as claimed in claim 3, wherein the substrate is a macroporous or microporous membrane, mesh or fabric.
5. A prosthesis as claimed in claim 4, wherein the fabric is non-woven, woven or preferably knitted.
6. A prosthesis as claimed in claim 3 or 4, wherein the fabric may be polymeric, polypropylene or polyester, most preferably polyethyleneterephthalate (PET) .
7. A prosthesis as claimed in any one of claims 1 to 3, wherein the substance capable of retaining the antimicrobial agent is a gel or has a gel-like or sponge¬ like open structure.
8. A prosthesis as claimed in any one of claims 1 to 3 or 7 wherein the substance capable of retaining the antimicrobial agent is a synthetic absorbable gel, preferably a polyglycollic acid gel.
9. A prosthesis as claimed in any one of claims 1 to , 7 or 8, wherein the substance capable of retaining the antimicrobial agent is proteinaceous.
10. A prosthesis as claimed in claim 9, wherein the proteinaceous substance is gelatin, which preferably is partially cross-linked.
11. The prosthesis as claimed in any one of claims 1 to 10, wherein the substrate comprises a non-resorbable membrane, mesh or fabric and wherein the substance capable of retaining the antimicrobial agent is resorbable to allow good tissue penetration by impregnation of the substance capable of retaining the antimicrobial agent into the interstices of the substrate and wherein said substance capable of retaining the antimicrobial agent is not a separate foil.
12. The prosthesis as claimed in claim 11, wherein the non-resorbable substrate comprises a natural or biological material cross-linked to render it biostable and non-resorbable.
13. The prosthesis as claimed in claim 11, wherein the non-resorbable substrate comprises a synthetic membrane, mesh or fabric.
14. A prosthesis as claimed in any one of claims 1 to 11, wherein the antimicrobial agent comprises an antibacterial agent.
15. A process for the preparation of a prosthesis as claimed in any one of claims 1 to 14, the process comprising loading the porous material with antimicrobial agent.
16. The use of an antimicrobial agent in the preparation of a prosthesis for the abdominal wall.
PCT/GB1995/001715 1994-07-21 1995-07-20 Prostheses for the abdominal wall WO1996003165A1 (en)

Priority Applications (3)

Application Number Priority Date Filing Date Title
EP95925930A EP0772468A1 (en) 1994-07-21 1995-07-20 Prostheses for the abdominal wall
JP8505567A JPH10503099A (en) 1994-07-21 1995-07-20 Prosthesis for abdominal wall
AU29872/95A AU2987295A (en) 1994-07-21 1995-07-20 Prostheses for the abdominal wall

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB9414746A GB9414746D0 (en) 1994-07-21 1994-07-21 Prosthetic material
GB9414746.9 1994-07-21

Publications (1)

Publication Number Publication Date
WO1996003165A1 true WO1996003165A1 (en) 1996-02-08

Family

ID=10758690

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/GB1995/001715 WO1996003165A1 (en) 1994-07-21 1995-07-20 Prostheses for the abdominal wall

Country Status (5)

Country Link
EP (1) EP0772468A1 (en)
JP (1) JPH10503099A (en)
AU (1) AU2987295A (en)
GB (1) GB9414746D0 (en)
WO (1) WO1996003165A1 (en)

Cited By (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE19613730A1 (en) * 1996-03-26 1997-10-02 Ethicon Gmbh Flat implant
US6113641A (en) * 1997-08-27 2000-09-05 Ethicon, Inc. Prosthesis for the obturation of a hernial canal
US6180848B1 (en) 1997-08-27 2001-01-30 Ethicon, Inc. Prosthesis obturating device for the obturation of a hernial canal
US6241768B1 (en) 1997-08-27 2001-06-05 Ethicon, Inc. Prosthetic device for the repair of a hernia
FR2840801A1 (en) * 2002-06-18 2003-12-19 Cie De Rech En Composants Impl A prosthetic implant used for the repair of hernias and ventral ruptures comprises a polyester or polypropylene textile support coated with a lyophilate of a biocompatible material, especially hyaluronic acid
WO2005051448A1 (en) * 2003-11-26 2005-06-09 Ethicon Gmbh Surgical implants for controlled release of medicaments
FR2865379A1 (en) * 2005-03-02 2005-07-29 Cie De Rech En Composants Impl Composite prosthetic implant useful for treating hernias or ruptures comprises a textile support coated with spongy bioadhesive coating of freeze-dried biocompatible material
WO2006032497A1 (en) 2004-09-24 2006-03-30 Aesculap Ag & Co. Kg Antimicrobial implant with a flexible porous structure
US8147478B2 (en) 2000-09-07 2012-04-03 Ams Research Corporation Coated sling material
RU2465654C1 (en) * 2011-07-27 2012-10-27 Николай Александрович Пострелов Method for simulating environment of replacing abdominal hernioplasty
US8317808B2 (en) 2008-02-18 2012-11-27 Covidien Lp Device and method for rolling and inserting a prosthetic patch into a body cavity
US8753359B2 (en) 2008-02-18 2014-06-17 Covidien Lp Device and method for deploying and attaching an implant to a biological tissue
US8758373B2 (en) 2008-02-18 2014-06-24 Covidien Lp Means and method for reversibly connecting a patch to a patch deployment device
US8808314B2 (en) 2008-02-18 2014-08-19 Covidien Lp Device and method for deploying and attaching an implant to a biological tissue
US8888811B2 (en) 2008-10-20 2014-11-18 Covidien Lp Device and method for attaching an implant to biological tissue
US8906045B2 (en) 2009-08-17 2014-12-09 Covidien Lp Articulating patch deployment device and method of use
US9034002B2 (en) 2008-02-18 2015-05-19 Covidien Lp Lock bar spring and clip for implant deployment device
US9044235B2 (en) 2008-02-18 2015-06-02 Covidien Lp Magnetic clip for implant deployment device
US9301826B2 (en) 2008-02-18 2016-04-05 Covidien Lp Lock bar spring and clip for implant deployment device
US9393002B2 (en) 2008-02-18 2016-07-19 Covidien Lp Clip for implant deployment device
US9393093B2 (en) 2008-02-18 2016-07-19 Covidien Lp Clip for implant deployment device
US9398944B2 (en) 2008-02-18 2016-07-26 Covidien Lp Lock bar spring and clip for implant deployment device
US9833240B2 (en) 2008-02-18 2017-12-05 Covidien Lp Lock bar spring and clip for implant deployment device
US9999424B2 (en) 2009-08-17 2018-06-19 Covidien Lp Means and method for reversibly connecting an implant to a deployment device

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2846549B1 (en) * 2002-11-04 2005-08-05 Sofradim Production PROSTHESIS OF REINFORCING TISSUE STRUCTURES
DE102004051487A1 (en) * 2004-10-21 2006-04-27 Ethicon Gmbh Surgical implant, useful for closing and covering soft tissue defects, e.g. for hernia repair, comprises a flat base having projections able to absorb body fluids

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0183365A2 (en) * 1984-11-30 1986-06-04 Vascutek Limited Vascular graft

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0183365A2 (en) * 1984-11-30 1986-06-04 Vascutek Limited Vascular graft

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
A. FREYRIE ET AL.: "INTERACTION BETWEEN VASCULAR PROSTHESES AND RIFAMPICIN IN THE PREVENTION OF THE GRAFTS INFECTION. AN EXPERIMENTAL STUDY.", INTERNATIONAL ANGIOLOGY, vol. 11, no. 2, pages 113 - 116 *
M. D'ADDATO ET AL.: "PREVENTION OF EARLY GRAFT INFECTION WITH RIFAMPICIN BONDED GELSEAL GRAFTS: A MULTICENTRE EXPERIMENTAL STUDY.", CARDIOVASCULAR SURGERY, vol. 2, no. 2, pages 254 - 258 *
SCOTT D. JENKINS ET AL.: "A COMPARISON OF PROSTHETIC MATERIALS USED TO REPAIR ABDOMINAL WALL DEFECTS.", SURGERY, vol. 94, no. 2, pages 392 - 398 *

Cited By (34)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6162962A (en) * 1996-03-26 2000-12-19 Ethicon Gmbh & Co., Kg Areal implant
DE19613730C2 (en) * 1996-03-26 2002-08-14 Ethicon Gmbh Flat implant for strengthening or closing body tissue
DE19613730A1 (en) * 1996-03-26 1997-10-02 Ethicon Gmbh Flat implant
US6113641A (en) * 1997-08-27 2000-09-05 Ethicon, Inc. Prosthesis for the obturation of a hernial canal
US6180848B1 (en) 1997-08-27 2001-01-30 Ethicon, Inc. Prosthesis obturating device for the obturation of a hernial canal
US6241768B1 (en) 1997-08-27 2001-06-05 Ethicon, Inc. Prosthetic device for the repair of a hernia
US8147478B2 (en) 2000-09-07 2012-04-03 Ams Research Corporation Coated sling material
FR2840801A1 (en) * 2002-06-18 2003-12-19 Cie De Rech En Composants Impl A prosthetic implant used for the repair of hernias and ventral ruptures comprises a polyester or polypropylene textile support coated with a lyophilate of a biocompatible material, especially hyaluronic acid
WO2003105726A1 (en) * 2002-06-18 2003-12-24 Compagnie De Recherche En Composants, Implants Et Materiels Pour L'application Clinique Composite prosthetic implant
WO2005051448A1 (en) * 2003-11-26 2005-06-09 Ethicon Gmbh Surgical implants for controlled release of medicaments
DE10355189B4 (en) * 2003-11-26 2015-04-30 Johnson & Johnson Medical Gmbh Method for producing a surgical implant and surgical implant
WO2006032497A1 (en) 2004-09-24 2006-03-30 Aesculap Ag & Co. Kg Antimicrobial implant with a flexible porous structure
JP2008514248A (en) * 2004-09-24 2008-05-08 アエスクラップ アーゲー ウント コー カーゲー Antibacterial implant with flexible and porous structure
FR2865379A1 (en) * 2005-03-02 2005-07-29 Cie De Rech En Composants Impl Composite prosthetic implant useful for treating hernias or ruptures comprises a textile support coated with spongy bioadhesive coating of freeze-dried biocompatible material
US8758373B2 (en) 2008-02-18 2014-06-24 Covidien Lp Means and method for reversibly connecting a patch to a patch deployment device
US9393093B2 (en) 2008-02-18 2016-07-19 Covidien Lp Clip for implant deployment device
US8317808B2 (en) 2008-02-18 2012-11-27 Covidien Lp Device and method for rolling and inserting a prosthetic patch into a body cavity
US8808314B2 (en) 2008-02-18 2014-08-19 Covidien Lp Device and method for deploying and attaching an implant to a biological tissue
US10695155B2 (en) 2008-02-18 2020-06-30 Covidien Lp Device and method for deploying and attaching an implant to a biological tissue
US10182898B2 (en) 2008-02-18 2019-01-22 Covidien Lp Clip for implant deployment device
US9005241B2 (en) 2008-02-18 2015-04-14 Covidien Lp Means and method for reversibly connecting a patch to a patch deployment device
US10159554B2 (en) 2008-02-18 2018-12-25 Covidien Lp Clip for implant deployment device
US9034002B2 (en) 2008-02-18 2015-05-19 Covidien Lp Lock bar spring and clip for implant deployment device
US9044235B2 (en) 2008-02-18 2015-06-02 Covidien Lp Magnetic clip for implant deployment device
US9107726B2 (en) 2008-02-18 2015-08-18 Covidien Lp Device and method for deploying and attaching an implant to a biological tissue
US9301826B2 (en) 2008-02-18 2016-04-05 Covidien Lp Lock bar spring and clip for implant deployment device
US9393002B2 (en) 2008-02-18 2016-07-19 Covidien Lp Clip for implant deployment device
US8753359B2 (en) 2008-02-18 2014-06-17 Covidien Lp Device and method for deploying and attaching an implant to a biological tissue
US9398944B2 (en) 2008-02-18 2016-07-26 Covidien Lp Lock bar spring and clip for implant deployment device
US9833240B2 (en) 2008-02-18 2017-12-05 Covidien Lp Lock bar spring and clip for implant deployment device
US8888811B2 (en) 2008-10-20 2014-11-18 Covidien Lp Device and method for attaching an implant to biological tissue
US9999424B2 (en) 2009-08-17 2018-06-19 Covidien Lp Means and method for reversibly connecting an implant to a deployment device
US8906045B2 (en) 2009-08-17 2014-12-09 Covidien Lp Articulating patch deployment device and method of use
RU2465654C1 (en) * 2011-07-27 2012-10-27 Николай Александрович Пострелов Method for simulating environment of replacing abdominal hernioplasty

Also Published As

Publication number Publication date
JPH10503099A (en) 1998-03-24
GB9414746D0 (en) 1994-09-07
EP0772468A1 (en) 1997-05-14
AU2987295A (en) 1996-02-22

Similar Documents

Publication Publication Date Title
EP0772468A1 (en) Prostheses for the abdominal wall
US20050085924A1 (en) Tissue infiltratable prosthetic device incorporating an antimicrobial substance
EP0717607B1 (en) Improved soft tissue implant
AU635197B2 (en) Antimicrobial device and method
US8337877B2 (en) Reduction of infection associated with medical device
JP5208752B2 (en) Antibacterial collagen construct
US5350583A (en) Cell-penetrable medical material and artificial skin
AU602726B2 (en) Heparin-containing adhesion prevention barrier and process
Dougherty et al. The natural history of alloplastic implants in orbital floor reconstruction: an animal model
CN1111509A (en) Protracted-release administration forms containing clindamycin palmitate
JPH0924093A (en) Grafting body, its application during surgical operation, and its preparation
EP0372969A1 (en) Low molecular weight heparin, heparinoid and hexuronyl hexosaminoglycan sulfate containing adhesion prevention barrier and process
US8445008B2 (en) Reduction of infection associated with medical device
CN111278478A (en) Kit for anchoring an implantable medical device
GB2187192A (en) Graft forming material
US20010003007A1 (en) Antibiotic treated implantable medical devices
US20210031018A1 (en) Methods and devices for eradicating biofilm and planktonic bacteria
JP2006528893A (en) Implant with antibacterial sustained action
CA1333050C (en) Biologic absorbable implant material for filling and closing soft-tissue cavities and method of its preparation
EP2331158B1 (en) Implantable device comprising a substrate pre-coated with stabilized fibrin
EP0411124A1 (en) Medical material permitting cells to enter thereinto and artificial skin
Gunasekaran et al. Collagen based biomaterials: an ideal way of increasing their resistance to infection
WO2005008932A2 (en) Microporous latex membranes, related articles and methods
Valente et al. Biodegradable Polymer (D, L-Lactide-ε-Caprolactone) in Aortic Vascular Prosthesis: Morphological Evaluation in an Animal Model
RU2141344C1 (en) Method of treatment of silicone prosthesis

Legal Events

Date Code Title Description
AK Designated states

Kind code of ref document: A1

Designated state(s): AM AU BB BG BR BY CA CN CZ EE FI GE HU IS JP KG KP KR KZ LK LR LT LV MD MG MN MX NO NZ PL RO RU SG SI SK TJ TM TT UA US UZ VN

AL Designated countries for regional patents

Kind code of ref document: A1

Designated state(s): KE MW SD SZ UG AT BE CH DE DK ES FR GB GR IE IT LU MC NL PT SE BF BJ CF CG CI CM GA GN ML MR NE SN TD TG

CFP Corrected version of a pamphlet front page
CR1 Correction of entry in section i
DFPE Request for preliminary examination filed prior to expiration of 19th month from priority date (pct application filed before 20040101)
121 Ep: the epo has been informed by wipo that ep was designated in this application
WWE Wipo information: entry into national phase

Ref document number: 1995925930

Country of ref document: EP

WWP Wipo information: published in national office

Ref document number: 1995925930

Country of ref document: EP

WWW Wipo information: withdrawn in national office

Ref document number: 1995925930

Country of ref document: EP