WO1996008582A3 - Specific and universal probes and amplification primers to rapidly detect and identify common bacterial pathogens and antibiotic resistance genes from clinical specimens for routine diagnosis in microbiology laboratories - Google Patents

Specific and universal probes and amplification primers to rapidly detect and identify common bacterial pathogens and antibiotic resistance genes from clinical specimens for routine diagnosis in microbiology laboratories Download PDF

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Publication number
WO1996008582A3
WO1996008582A3 PCT/CA1995/000528 CA9500528W WO9608582A3 WO 1996008582 A3 WO1996008582 A3 WO 1996008582A3 CA 9500528 W CA9500528 W CA 9500528W WO 9608582 A3 WO9608582 A3 WO 9608582A3
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Prior art keywords
antibiotic resistance
resistance genes
bacterial
specific
amplification primers
Prior art date
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PCT/CA1995/000528
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French (fr)
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WO1996008582A2 (en
Inventor
Michel G Bergeron
Marc Ouellette
Paul H Roy
Original Assignee
Michel G Bergeron
Marc Ouellette
Paul H Roy
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First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=23177744&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=WO1996008582(A3) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Priority to JP50978196A priority Critical patent/JP4176146B2/en
Priority to AU34681/95A priority patent/AU705198C/en
Priority to DK95931109T priority patent/DK0804616T3/en
Priority to MX9701847A priority patent/MX9701847A/en
Priority to AT95931109T priority patent/ATE219524T1/en
Application filed by Michel G Bergeron, Marc Ouellette, Paul H Roy filed Critical Michel G Bergeron
Priority to EP95931109A priority patent/EP0804616B1/en
Priority to DE69527154T priority patent/DE69527154T2/en
Priority to BR9508918A priority patent/BR9508918A/en
Priority to CA2199144A priority patent/CA2199144C/en
Priority to NZ292494A priority patent/NZ292494A/en
Publication of WO1996008582A2 publication Critical patent/WO1996008582A2/en
Publication of WO1996008582A3 publication Critical patent/WO1996008582A3/en
Priority to NO19971111A priority patent/NO971111L/en

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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6888—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for detection or identification of organisms
    • C12Q1/689—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for detection or identification of organisms for bacteria
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
    • C07K14/21—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Pseudomonadaceae (F)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
    • C07K14/21—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Pseudomonadaceae (F)
    • C07K14/212—Moraxellaceae, e.g. Acinetobacter, Moraxella, Oligella, Psychrobacter
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
    • C07K14/24—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Enterobacteriaceae (F), e.g. Citrobacter, Serratia, Proteus, Providencia, Morganella, Yersinia
    • C07K14/245—Escherichia (G)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
    • C07K14/24—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Enterobacteriaceae (F), e.g. Citrobacter, Serratia, Proteus, Providencia, Morganella, Yersinia
    • C07K14/26—Klebsiella (G)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
    • C07K14/285—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Pasteurellaceae (F), e.g. Haemophilus influenza
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
    • C07K14/305—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Micrococcaceae (F)
    • C07K14/31—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Micrococcaceae (F) from Staphylococcus (G)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
    • C07K14/315—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Streptococcus (G), e.g. Enterococci
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
    • C07K14/315—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Streptococcus (G), e.g. Enterococci
    • C07K14/3156—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Streptococcus (G), e.g. Enterococci from Streptococcus pneumoniae (Pneumococcus)
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    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/65—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression using markers
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    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/16—Primer sets for multiplex assays

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  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
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  • Gastroenterology & Hepatology (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Analytical Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Microbiology (AREA)
  • Biomedical Technology (AREA)
  • Communicable Diseases (AREA)
  • Immunology (AREA)
  • Plant Pathology (AREA)
  • Pulmonology (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)

Abstract

The present invention relates to DNA-based methods for universal bacterial detection, for specific detection of the pneumoniae, Pseudomonas aeruginosa, Proteus mirabilis, Streptococcus pneumoniae, Staphylococcus aureus, Staphylococcus epiderminis, Enterococcus faecalis, Staphylococcus saprophyticus, Streptococcus pyogenes, Haemophilus influenzae and Moraxella catarrhalis as well as for specific detection of commonly encountered and clinically relevant bacterial antibiotic resistance genes directly from clinical specimens or, alternatively, from a bacterial colony. The above bacterial species can account for as much as 80 % of bacterial pathogens isolated in routine microbiology laboratories. The core of this invention consists primarily of the DNA sequences from all species-specific genomic DNA fragments selected by hybridization from genomic libraries or, alternatively, selected from data banks as well as any oligonucleotide sequences derived from these sequences which can be used as probes or amplification primers for PCR or any other nucleic acid amplification methods. This invention also includes DNA sequences from the selected clinically relevant antibiotic resistance genes.
PCT/CA1995/000528 1994-09-12 1995-09-12 Specific and universal probes and amplification primers to rapidly detect and identify common bacterial pathogens and antibiotic resistance genes from clinical specimens for routine diagnosis in microbiology laboratories WO1996008582A2 (en)

Priority Applications (11)

Application Number Priority Date Filing Date Title
NZ292494A NZ292494A (en) 1994-09-12 1995-09-12 Specific and universal probes and amplification primers for determining the presence of nucleic acids to detect and identify common bacterial pathogens and antibiotic resistant genes; sequences
DE69527154T DE69527154T2 (en) 1994-09-12 1995-09-12 SPECIFIC AND UNIVERSAL AMPLIFICATION PRIMER FOR RAPID DETERMINATION AND IDENTIFICATION OF COMMON BACTERIAL PATHOGENES AND ANTIBIOTIC RESISTANCE GENES IN CLINICAL SAMPLES FOR ROUTINE DIAGNOSIS IN MICROBIOLOGY LABORATORIES
DK95931109T DK0804616T3 (en) 1994-09-12 1995-09-12 Specific and universal amplification primers for rapid detection and identification of commonly occurring bacterial pathogens and antibiotic resistance genes from clinical trials for routine diagnosis in microbiological laboratories
MX9701847A MX9701847A (en) 1994-09-12 1995-09-12 Specific and universal probes and amplification primers to rapidly detect .and identify common bacterial pathogens and antibiotic resistance genes from clinical specimens for routine diagnosis in microbiology laboratories.
AT95931109T ATE219524T1 (en) 1994-09-12 1995-09-12 SPECIFIC AND UNIVERSAL AMPLIFICATION PRIMERS FOR THE RAPID DETERMINATION AND IDENTIFICATION OF COMMON BACTERIAL PATHOGENS AND ANTIBIOTIC RESISTANCE GENES IN CLINICAL SAMPLES FOR ROUTINE DIAGNOSIS IN MICROBIOLOGY LABORATORIES
JP50978196A JP4176146B2 (en) 1994-09-12 1995-09-12 Specific and universal probes and amplification primers for the rapid detection and identification of common bacterial pathogens and antibiotic resistance genes from clinical specimens for routine diagnosis in microbiology laboratories
EP95931109A EP0804616B1 (en) 1994-09-12 1995-09-12 Specific and universal amplification primers to rapidly detect and identify common bacterial pathogens and antibiotic resistance genes from clinical specimens for routine diagnosis in microbiology laboratories
AU34681/95A AU705198C (en) 1994-09-12 1995-09-12 Specific and universal probes and amplification primers to rapidly detect and identify common bacterial pathogens and antibiotic resistance genes from clinical specimens for routine diagnosis in microbiology laboratories
BR9508918A BR9508918A (en) 1994-09-12 1995-09-12 Processes for determining the presence and / or quantity of bacterial species nucleic acids for the detection, identification and / or quantification of bacterial species to assess bacterial resistance to antibiotics recombinant host plasmid oligonucleotide recombinant plasmid and diagnostic kit
CA2199144A CA2199144C (en) 1994-09-12 1995-09-12 Specific and universal probes and amplification primers to rapidly detect and identify common bacterial pathogens and antibiotic resistance genes from clinical specimens for routine diagnosis in microbiology laboratories
NO19971111A NO971111L (en) 1994-09-12 1997-03-11 Specific and universal probes and amplification primers for rapid detection and identification of common bacterial pathogens and antibiotic resistance genes from clinical trials for routine diagnosis in microbiology laboratories

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US30473294A 1994-09-12 1994-09-12
US08/304,732 1994-09-12

Publications (2)

Publication Number Publication Date
WO1996008582A2 WO1996008582A2 (en) 1996-03-21
WO1996008582A3 true WO1996008582A3 (en) 1996-07-18

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ID=23177744

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Application Number Title Priority Date Filing Date
PCT/CA1995/000528 WO1996008582A2 (en) 1994-09-12 1995-09-12 Specific and universal probes and amplification primers to rapidly detect and identify common bacterial pathogens and antibiotic resistance genes from clinical specimens for routine diagnosis in microbiology laboratories

Country Status (14)

Country Link
US (3) US6001564A (en)
EP (2) EP1138786B1 (en)
JP (2) JP4176146B2 (en)
AT (1) ATE219524T1 (en)
BR (1) BR9508918A (en)
CA (1) CA2199144C (en)
DE (1) DE69527154T2 (en)
DK (1) DK0804616T3 (en)
ES (1) ES2176336T3 (en)
MX (1) MX9701847A (en)
NO (1) NO971111L (en)
NZ (1) NZ292494A (en)
PT (1) PT804616E (en)
WO (1) WO1996008582A2 (en)

Families Citing this family (156)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20020055101A1 (en) * 1995-09-11 2002-05-09 Michel G. Bergeron Specific and universal probes and amplification primers to rapidly detect and identify common bacterial pathogens and antibiotic resistance genes from clinical specimens for routine diagnosis in microbiology laboratories
US6001564A (en) * 1994-09-12 1999-12-14 Infectio Diagnostic, Inc. Species specific and universal DNA probes and amplification primers to rapidly detect and identify common bacterial pathogens and associated antibiotic resistance genes from clinical specimens for routine diagnosis in microbiology laboratories
AUPN350795A0 (en) * 1995-06-13 1995-07-06 Australian National University, The Nucleic acid molecule and its uses in determining pathogenicity of Staphylococcus
US5994066A (en) * 1995-09-11 1999-11-30 Infectio Diagnostic, Inc. Species-specific and universal DNA probes and amplification primers to rapidly detect and identify common bacterial pathogens and associated antibiotic resistance genes from clinical specimens for routine diagnosis in microbiology laboratories
DE69736667T2 (en) * 1996-07-16 2007-09-06 Gen-Probe Inc., San Diego PROCESS FOR THE DETECTION AND AMPLIFICATION OF NUCLEIC ACID SEQUENCES USING MODIFIED OLIGONUCLEOTIDES WITH INCREASED TARGET MELT TEMPERATURE (TM)
US7070925B1 (en) * 1996-07-16 2006-07-04 Gen-Probe Incorporated Method for determining the presence of an RNA analyte in a sample using a modified oligonucleotide probe
GB9619071D0 (en) * 1996-09-12 1996-10-23 Smithkline Beecham Plc Novel compounds
EP1770164B1 (en) 1996-10-31 2010-09-01 Human Genome Sciences, Inc. Streptococcus pneumoniae antigens and vaccines
US20030049636A1 (en) * 1999-05-03 2003-03-13 Bergeron Michel G. Species-specific, genus-specific and universal DNA probes and amplification primers to rapidly detect and identify common bacterial and fungal pathogens and associated antibiotic resistance genes from clinical specimens for diagnosis in microbiology laboratories
US20100267012A1 (en) * 1997-11-04 2010-10-21 Bergeron Michel G Highly conserved genes and their use to generate probes and primers for detection of microorganisms
EP0951569A2 (en) * 1996-12-23 1999-10-27 University Of Chicago Customized oligonucleotide microchips as multiple biosensors
US6458584B1 (en) * 1996-12-23 2002-10-01 University Of Chicago Customized oligonucleotide microchips that convert multiple genetic information to simple patterns, are portable and reusable
EP0994965A2 (en) * 1997-04-22 2000-04-26 Bavarian Nordic Research Institute A/S Taqman?tm -pcr for the detection of pathogenic e. coli strains
DE19717346C2 (en) * 1997-04-24 1999-05-20 Max Planck Gesellschaft DNA probes, methods and kit for identifying antibiotic resistant bacterial strains
US6570001B1 (en) * 1997-06-20 2003-05-27 Institut Pasteur Polynucleotides and their use for detecting resistance to streptogramin A or to streptogramin B and related compounds
US7135560B1 (en) 1997-07-02 2006-11-14 Sanofi Pasteur Limited Nucleic acid and amino acid sequences relating to Streptococcus pneumoniae for diagnostics and therapeutics
US6800744B1 (en) 1997-07-02 2004-10-05 Genome Therapeutics Corporation Nucleic acid and amino acid sequences relating to Streptococcus pneumoniae for diagnostics and therapeutics
US6503709B1 (en) 1997-07-03 2003-01-07 Id Biomedical Corporation Methods for rapidly detecting methicillin resistant staphylococci
US6274316B1 (en) * 1997-07-03 2001-08-14 Id Biomedical Corporation Compositions and methods for detecting vancomycin resistant enterococci by cycling probe reactions
US6136533A (en) * 1997-07-03 2000-10-24 Id Biomedical Additives for use in cycling probe reactions
US7060458B1 (en) 1997-08-14 2006-06-13 Wyeth Nucleic acid and amino acid sequences relating to Staphylococcus epidermidis for diagnostics and therapeutics
US6380370B1 (en) 1997-08-14 2002-04-30 Genome Therapeutics Corporation Nucleic acid and amino acid sequences relating to Staphylococcus epidermidis for diagnostics and therapeutics
US6551795B1 (en) 1998-02-18 2003-04-22 Genome Therapeutics Corporation Nucleic acid and amino acid sequences relating to pseudomonas aeruginosa for diagnostics and therapeutics
CA2329057A1 (en) 1998-05-22 1999-12-02 Creatogen Gmbh Demonstrating resistance to antibiotics in microorganisms
US6242223B1 (en) * 1998-09-28 2001-06-05 Creighton University Primers for use in detecting beta-lactamases
GB9904804D0 (en) 1999-03-02 1999-04-28 King S College London Identification of bacteria
US6673910B1 (en) 1999-04-08 2004-01-06 Genome Therapeutics Corporation Nucleic acid and amino acid sequences relating to M. catarrhalis for diagnostics and therapeutics
US20030215821A1 (en) * 1999-04-20 2003-11-20 Kevin Gunderson Detection of nucleic acid reactions on bead arrays
US20060275782A1 (en) 1999-04-20 2006-12-07 Illumina, Inc. Detection of nucleic acid reactions on bead arrays
US6821770B1 (en) * 1999-05-03 2004-11-23 Gen-Probe Incorporated Polynucleotide matrix-based method of identifying microorganisms
US20020086289A1 (en) * 1999-06-15 2002-07-04 Don Straus Genomic profiling: a rapid method for testing a complex biological sample for the presence of many types of organisms
AU6011100A (en) * 1999-07-30 2001-02-19 Institut Pasteur Detection of a gene, vatd, encoding an acetyltransferase inactivating streptogramin
EP1210365A2 (en) * 1999-08-17 2002-06-05 Beth Israel Deaconess Medical Center, Inc. Methods and compositions for restoring antibiotic susceptibility in glycopeptide-resistant enterococcus
EP1246935B1 (en) 1999-09-28 2013-08-14 Geneohm Sciences Canada Inc. Highly conserved genes and their use to generate probes and primers for detection of microorganisms
US6878517B1 (en) * 1999-12-15 2005-04-12 Congra Grocery Products Company Multispecies food testing and characterization organoleptic properties
US7955794B2 (en) * 2000-09-21 2011-06-07 Illumina, Inc. Multiplex nucleic acid reactions
US7582420B2 (en) 2001-07-12 2009-09-01 Illumina, Inc. Multiplex nucleic acid reactions
US8076063B2 (en) 2000-02-07 2011-12-13 Illumina, Inc. Multiplexed methylation detection methods
JP2001333783A (en) * 2000-05-29 2001-12-04 Tosoh Corp Oligonucleotide for detecting methicillin-resistant staphylococcus aureus
JP2001353000A (en) * 2000-06-09 2001-12-25 Tosoh Corp Detection of mec a gene of methicilinresistant staphyrococcus aureus(mrsa)
US20040005555A1 (en) * 2000-08-31 2004-01-08 Rothman Richard E. Molecular diagnosis of bactermia
GB0022017D0 (en) * 2000-09-08 2000-10-25 Univ Dundee Cell assays
US7666588B2 (en) 2001-03-02 2010-02-23 Ibis Biosciences, Inc. Methods for rapid forensic analysis of mitochondrial DNA and characterization of mitochondrial DNA heteroplasmy
AT410444B (en) * 2001-03-02 2003-04-25 Oesterr Forsch Seibersdorf METHOD FOR DETECTING NUCLEIC ACID MOLECULES
US20040121314A1 (en) * 2002-12-06 2004-06-24 Ecker David J. Methods for rapid detection and identification of bioagents in containers
US20030027135A1 (en) 2001-03-02 2003-02-06 Ecker David J. Method for rapid detection and identification of bioagents
US7226739B2 (en) 2001-03-02 2007-06-05 Isis Pharmaceuticals, Inc Methods for rapid detection and identification of bioagents in epidemiological and forensic investigations
US20040121309A1 (en) 2002-12-06 2004-06-24 Ecker David J. Methods for rapid detection and identification of bioagents in blood, bodily fluids, and bodily tissues
US7718354B2 (en) 2001-03-02 2010-05-18 Ibis Biosciences, Inc. Methods for rapid identification of pathogens in humans and animals
US7052837B2 (en) * 2001-03-13 2006-05-30 The Board Of Trustees Of The University Of Arkansas Histoplasma capsulatum catalase sequences and their use in the detection of Histoplamsa capsulatum and histoplasmosis
DE10124342A1 (en) * 2001-05-18 2002-11-28 Biotecon Diagnostics Gmbh Amplification method for Yersinia pestis and Yersinia pseudotuberculosis, useful for their rapid detection and differentiation, also new primers and probes
CA2348042A1 (en) 2001-06-04 2002-12-04 Ann Huletsky Sequences for detection and identification of methicillin-resistant staphylococcus aureus
US20020187490A1 (en) * 2001-06-07 2002-12-12 Michigan State University Microbial identification chip based on DNA-DNA hybridization
NZ530343A (en) * 2001-06-22 2007-01-26 Marshfield Clinic Methods and oligonucleotides for the detection of E. coli 0157:H7
US7217510B2 (en) 2001-06-26 2007-05-15 Isis Pharmaceuticals, Inc. Methods for providing bacterial bioagent characterizing information
US8073627B2 (en) 2001-06-26 2011-12-06 Ibis Biosciences, Inc. System for indentification of pathogens
KR100439532B1 (en) * 2001-07-03 2004-07-09 주식회사 코메드 Multiplex polymerase chain reaction for rapidly detecting antibiotic resistance of Staphyllococcus strains
US20030148314A1 (en) * 2001-08-01 2003-08-07 Millennium Pharmaceuticals, Inc. Compositions, kits, and methods for identification, assessment, prevention, and therapy of colon cancer
US20040002080A1 (en) * 2001-12-14 2004-01-01 Creighton University Primers for use in detecting beta-lactamases
US20050170346A1 (en) * 2001-12-19 2005-08-04 Quantibact A/S C/O Novi A/S Method and a kit for determination of a microbial count
AU2003208959A1 (en) 2002-01-30 2003-09-02 Id Biomedical Corporation Methods for detecting vancomycin-resistant microorganisms and compositions therefor
US6593093B1 (en) * 2002-02-20 2003-07-15 Mayo Foundation For Medical Education And Research Detection of group a Streptococcus
US8211657B2 (en) * 2002-04-29 2012-07-03 The Board Of Trustees Of The University Of Arkansas Capillary-column-based bioseparator/bioreactor with an optical/electrochemical detector for detection of microbial pathogens
US7045291B2 (en) * 2002-05-17 2006-05-16 Creighton University Multiplex PCR for the detection of AmpC beta-lactamase genes
US20040081646A1 (en) * 2002-08-29 2004-04-29 Engler Jeffrey A. Group B Streptococcal phage lysin
DE10244456A1 (en) * 2002-09-24 2004-04-15 Hain Lifescience Gmbh Methods for the detection and differentiation of bacteria
US7074598B2 (en) * 2002-09-25 2006-07-11 Mayo Foundation For Medical Education And Research Detection of vancomycin-resistant enterococcus spp.
US7074599B2 (en) * 2002-09-27 2006-07-11 Mayo Foundation For Medical Education And Research Detection of mecA-containing Staphylococcus spp.
US7217519B1 (en) 2002-11-21 2007-05-15 The Board Of Trustees Of The University Of Arkansas Histoplasma capsulatum chitin synthase sequences and their use for detection of Histoplasma capsulatum and histoplasmosis
US20040101860A1 (en) * 2002-11-27 2004-05-27 Jones Alison M. Predicting animal performance
US20040259226A1 (en) * 2003-05-30 2004-12-23 Robey W. Wade Monitoring for and detecting microbes used in bioterrorism
CA2508726A1 (en) 2002-12-06 2004-07-22 Isis Pharmaceuticals, Inc. Methods for rapid identification of pathogens in humans and animals
CA2507240C (en) * 2002-12-06 2011-05-24 F. Hoffmann-La Roche Ag Multiplex assay detection of pathogenic organisms
WO2005017488A2 (en) * 2003-01-23 2005-02-24 Science Applications International Corporation Method and system for identifying biological entities in biological and environmental samples
US20040185446A1 (en) * 2003-03-18 2004-09-23 Jones Alison M. Cpn60 targets for quantification of microbial species
US20040185454A1 (en) * 2003-03-21 2004-09-23 Jones Alison M. Identification and quantification of microbial species in a sample
US20040185434A1 (en) * 2003-03-21 2004-09-23 Robey W. Wade Detecting microbial contamination in animal by-products
US8046171B2 (en) 2003-04-18 2011-10-25 Ibis Biosciences, Inc. Methods and apparatus for genetic evaluation
US8057993B2 (en) 2003-04-26 2011-11-15 Ibis Biosciences, Inc. Methods for identification of coronaviruses
US8158354B2 (en) 2003-05-13 2012-04-17 Ibis Biosciences, Inc. Methods for rapid purification of nucleic acids for subsequent analysis by mass spectrometry by solution capture
US7964343B2 (en) 2003-05-13 2011-06-21 Ibis Biosciences, Inc. Method for rapid purification of nucleic acids for subsequent analysis by mass spectrometry by solution capture
US20040241662A1 (en) * 2003-05-30 2004-12-02 Robey W. Wade Detecting microbial contamination in grain and related products
DE10339609A1 (en) * 2003-08-28 2005-03-24 Forschungszentrum Karlsruhe Gmbh Oligonucleotide, method and system for the detection of antibiotic resistance-mediating genes in microorganisms by means of real-time PCR
US20070248954A1 (en) * 2003-09-10 2007-10-25 Creighton University Primers for Use in Detecting Beta-Lactamases
US8546082B2 (en) 2003-09-11 2013-10-01 Ibis Biosciences, Inc. Methods for identification of sepsis-causing bacteria
US7956175B2 (en) 2003-09-11 2011-06-07 Ibis Biosciences, Inc. Compositions for use in identification of bacteria
US8097416B2 (en) 2003-09-11 2012-01-17 Ibis Biosciences, Inc. Methods for identification of sepsis-causing bacteria
US20050058985A1 (en) * 2003-09-12 2005-03-17 Dodgson Kirsty Jane Method and kit for identifying vancomycin-resistant enterococcus
US7666592B2 (en) 2004-02-18 2010-02-23 Ibis Biosciences, Inc. Methods for concurrent identification and quantification of an unknown bioagent
US8119336B2 (en) 2004-03-03 2012-02-21 Ibis Biosciences, Inc. Compositions for use in identification of alphaviruses
WO2005117270A2 (en) 2004-05-24 2005-12-08 Isis Pharmaceuticals, Inc. Mass spectrometry with selective ion filtration by digital thresholding
US20050266411A1 (en) 2004-05-25 2005-12-01 Hofstadler Steven A Methods for rapid forensic analysis of mitochondrial DNA
US7811753B2 (en) 2004-07-14 2010-10-12 Ibis Biosciences, Inc. Methods for repairing degraded DNA
CA2572178A1 (en) * 2004-07-26 2006-03-16 Nanosphere, Inc. Method for distinguishing methicillin resistant s. aureus from methicillin sensitive s. aureus in a mixed culture
TWI352739B (en) * 2004-08-04 2011-11-21 Suntory Holdings Ltd Bacteria detection instrument, bacteria detection
US7309589B2 (en) 2004-08-20 2007-12-18 Vironix Llc Sensitive detection of bacteria by improved nested polymerase chain reaction targeting the 16S ribosomal RNA gene and identification of bacterial species by amplicon sequencing
WO2006135400A2 (en) 2004-08-24 2006-12-21 Isis Pharmaceuticals, Inc. Methods for rapid identification of recombinant organisms
KR100763906B1 (en) * 2004-12-23 2007-10-05 삼성전자주식회사 9 9 A primer set capable of specifically amplifying a target sequence found in 9 bacterial species and probe oligonucleotide specifically hybridizable with each target sequence of the 9 bacterial species
US8084207B2 (en) 2005-03-03 2011-12-27 Ibis Bioscience, Inc. Compositions for use in identification of papillomavirus
WO2006094238A2 (en) 2005-03-03 2006-09-08 Isis Pharmaceuticals, Inc. Compositions for use in identification of adventitious viruses
US20080280775A1 (en) * 2005-03-18 2008-11-13 Eppendorf Ag Determination of Antibiotic Resistance in Staphylococcus Aureus
US20060210998A1 (en) * 2005-03-18 2006-09-21 Christiane Kettlitz Determination of antibiotic resistance in staphylococcus aureus
DE102005015005A1 (en) * 2005-04-01 2006-10-05 Qiagen Gmbh Process for treating a sample containing biomolecules
US20060240442A1 (en) * 2005-04-20 2006-10-26 Vevea Dirk N Methods and oligonucleotides for the detection of Salmonella SP., E coli 0157:H7, and Listeria monocytogenes
US20060246463A1 (en) * 2005-04-20 2006-11-02 Vevea Dirk N Methods and oligonucleotides for the detection of Salmonella SP., E coli 0157:H7, and Listeria monocytogenes
US20060252069A1 (en) * 2005-04-21 2006-11-09 Zhang Kunyan Pcr for mrsa sccmec typing
CA2616281C (en) 2005-07-21 2014-04-22 Isis Pharmaceuticals, Inc. Methods for rapid identification and quantitation of mitochondrial dna variants
US11834720B2 (en) 2005-10-11 2023-12-05 Geneohm Sciences, Inc. Sequences for detection and identification of methicillin-resistant Staphylococcus aureus (MRSA) of MREJ types xi to xx
WO2007056680A2 (en) * 2005-11-03 2007-05-18 Forsyth Dental Infirmary For Children Methods and arrays for identifying human microflora
WO2007075026A1 (en) * 2005-12-27 2007-07-05 Samsung Electronics Co., Ltd Primers, probes, microarray, and method for specific detection of nine respiratory disease-associated bacterial species
CN100465289C (en) * 2006-01-18 2009-03-04 博奥生物有限公司 Method for detecting drug resistant gene of gramnegative bacterium and its special chip and kit
US8460879B2 (en) 2006-02-21 2013-06-11 The Trustees Of Tufts College Methods and arrays for target analyte detection and determination of target analyte concentration in solution
US11237171B2 (en) 2006-02-21 2022-02-01 Trustees Of Tufts College Methods and arrays for target analyte detection and determination of target analyte concentration in solution
EP2010679A2 (en) 2006-04-06 2009-01-07 Ibis Biosciences, Inc. Compositions for the use in identification of fungi
US7947441B2 (en) * 2006-04-14 2011-05-24 University Of South Florida Molecular detection and quantification of Enterococci
AT504194B1 (en) * 2006-09-07 2008-07-15 Oesterr Rotes Kreuz BACTERIA DETECTION
AU2007353877B2 (en) 2006-09-14 2012-07-19 Ibis Biosciences, Inc. Targeted whole genome amplification method for identification of pathogens
KR100923303B1 (en) * 2006-09-28 2009-10-23 삼성전자주식회사 A primer set for amplifying target sequences of 10 bacterial species causing respiratory diseases, probe set specifically hybridizable with the target sequences of the 10 bacterial species, a microarray having immobilized the probe set and a method for detecting the presence of one or more of the 10 bacterial species
US8148511B2 (en) * 2006-09-28 2012-04-03 The University Of North Carolina At Chapel Hill Methods and compositions for the detection and quantification of E. coli and Enterococcus
KR100868765B1 (en) 2006-09-29 2008-11-17 삼성전자주식회사 A primer set for amplifying target sequences of bacterial species resistant to antibiotics, probe set specifically hybridizable with the target sequences of the bacterial species, a microarray having immobilized the probe set and a method for detecting the presence of one or more of the bacterial species
WO2008104002A2 (en) 2007-02-23 2008-08-28 Ibis Biosciences, Inc. Methods for rapid forensic dna analysis
US20080243865A1 (en) * 2007-03-28 2008-10-02 Oracle International Corporation Maintaining global state of distributed transaction managed by an external transaction manager for clustered database systems
EP2150625B1 (en) 2007-04-19 2013-03-20 Molecular Detection Inc. Methods, compositions and kits for detection and analysis of antibiotic-resistant bacteria
US9598724B2 (en) 2007-06-01 2017-03-21 Ibis Biosciences, Inc. Methods and compositions for multiple displacement amplification of nucleic acids
US7888075B2 (en) * 2007-07-31 2011-02-15 Quest Diagnostics Investments Incorporated Detection of methicillin-resistant and methicillin-sensitive Staphylococcus aureus in biological samples
EP2201374B1 (en) 2007-08-30 2015-10-07 Trustees Of Tufts College Methods for determining the concentration of an analyte in solution.
FI121428B (en) 2008-01-17 2010-11-15 Mobidiag Oy Broad-spectrum primers, test kit and method for detection and identification of bacterial species
US8148163B2 (en) 2008-09-16 2012-04-03 Ibis Biosciences, Inc. Sample processing units, systems, and related methods
US8534447B2 (en) 2008-09-16 2013-09-17 Ibis Biosciences, Inc. Microplate handling systems and related computer program products and methods
WO2010033599A2 (en) 2008-09-16 2010-03-25 Ibis Biosciences, Inc. Mixing cartridges, mixing stations, and related kits, systems, and methods
US8222047B2 (en) 2008-09-23 2012-07-17 Quanterix Corporation Ultra-sensitive detection of molecules on single molecule arrays
US20100075439A1 (en) * 2008-09-23 2010-03-25 Quanterix Corporation Ultra-sensitive detection of molecules by capture-and-release using reducing agents followed by quantification
EP2396803A4 (en) 2009-02-12 2016-10-26 Ibis Biosciences Inc Ionization probe assemblies
WO2010104798A1 (en) 2009-03-08 2010-09-16 Ibis Biosciences, Inc. Bioagent detection methods
US9393564B2 (en) 2009-03-30 2016-07-19 Ibis Biosciences, Inc. Bioagent detection systems, devices, and methods
US8950604B2 (en) 2009-07-17 2015-02-10 Ibis Biosciences, Inc. Lift and mount apparatus
EP2454000A4 (en) 2009-07-17 2016-08-10 Ibis Biosciences Inc Systems for bioagent identification
WO2011014811A1 (en) 2009-07-31 2011-02-03 Ibis Biosciences, Inc. Capture primers and capture sequence linked solid supports for molecular diagnostic tests
US9080209B2 (en) 2009-08-06 2015-07-14 Ibis Biosciences, Inc. Non-mass determined base compositions for nucleic acid detection
US20110045458A1 (en) * 2009-08-20 2011-02-24 Mayo Foundation For Medical Education And Research Detection of Enterovirus
EP2957641B1 (en) 2009-10-15 2017-05-17 Ibis Biosciences, Inc. Multiple displacement amplification
US8236574B2 (en) 2010-03-01 2012-08-07 Quanterix Corporation Ultra-sensitive detection of molecules or particles using beads or other capture objects
US8415171B2 (en) 2010-03-01 2013-04-09 Quanterix Corporation Methods and systems for extending dynamic range in assays for the detection of molecules or particles
EP2542890B1 (en) 2010-03-01 2015-05-06 Quanterix Corporation Methods for extending dynamic range in assays for the detection of molecules or particles
US9678068B2 (en) 2010-03-01 2017-06-13 Quanterix Corporation Ultra-sensitive detection of molecules using dual detection methods
US9758840B2 (en) 2010-03-14 2017-09-12 Ibis Biosciences, Inc. Parasite detection via endosymbiont detection
US9952237B2 (en) 2011-01-28 2018-04-24 Quanterix Corporation Systems, devices, and methods for ultra-sensitive detection of molecules or particles
US20140302532A1 (en) 2011-04-12 2014-10-09 Quanterix Corporation Methods of determining a treatment protocol for and/or a prognosis of a patient's recovery from a brain injury
WO2013086201A1 (en) 2011-12-06 2013-06-13 Dowd Scot E Universal or broad range assays and multi-tag sample specific diagnostic process using non-optical sequencing
WO2014113502A1 (en) 2013-01-15 2014-07-24 Quanterix Corporation Detection of dna or rna using single molecule arrays and other techniques
EP3090069A4 (en) * 2014-01-02 2017-07-19 Becton, Dickinson and Company Detection of entamoeba nucleic acids
US9863009B2 (en) 2014-09-19 2018-01-09 University Of Dammam Sequence specific primer pool for multiplex PCR and method of detecting microbial infections in thalassemia patients
CN107630071A (en) * 2016-07-18 2018-01-26 北京普若博升生物科技有限公司 The detection kit of SHV type extended spectrumβ-lactamase drug resistant genes
CN110062623A (en) * 2016-11-01 2019-07-26 合成生物制品有限公司 For weakening the method and composition of antibiotic resistance
CN114214319A (en) * 2021-12-28 2022-03-22 上海交通大学医学院附属上海儿童医学中心 Kit for quickly, simply and low-cost screening of urinary tract infection pathogenic bacteria and application thereof
CN115062933B (en) * 2022-06-01 2023-04-18 生态环境部南京环境科学研究所 Multi-level risk assessment method for microbial drug resistance of antibiotic residues in water environment

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0438115A2 (en) * 1990-01-19 1991-07-24 F. Hoffmann-La Roche Ag Process for detection of water-borne microbial pathogens and indicators of human fecal contamination in water samples and kits therefor
WO1993003186A1 (en) * 1991-07-31 1993-02-18 F.Hoffmann-La Roche Ag Methods and reagents for detection of bacteria in cerebrospinal fluid
WO1994002645A1 (en) * 1992-07-17 1994-02-03 Aprogenex, Inc. Rapid detection of biopolymers in stained specimens

Family Cites Families (55)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE4038804A1 (en) * 1990-10-09 1992-04-16 Boehringer Mannheim Gmbh METHOD FOR GENUS AND / AND SPECIES-SPECIFIC DETECTION OF BACTERIA IN A SAMPLING LIQUID
FR2567541B1 (en) * 1984-07-13 1987-02-06 Pasteur Institut DNA PROBE AND METHOD FOR THE DETECTION OF "SHIGELLES" AND ENTERO-INVASIVE STRAINS OF ESCHERICHIA COLI
FR2568588B1 (en) * 1984-08-02 1987-02-13 Inst Nat Sante Rech Med PROBE AND METHOD FOR THE DETECTION OF DETERMINED MICRO-ORGANISMS, IN PARTICULAR LEGIONELLA IN THE MEDIA CONTAINING THE SAME
FR2584419B1 (en) * 1985-07-08 1987-11-13 Pasteur Institut PROBE AND METHOD FOR DETECTING FACTORS OF RESISTANCE TO ERYTHROMYCIN IN CELL CULTURES, ESPECIALLY BACTERIAL
FR2599743B1 (en) * 1986-06-10 1988-09-30 Pasteur Institut DNA FRAGMENT COMPRISING AT LEAST ONE PART OF AN ERYTHROMYCIN RESISTANCE GENE, METHOD FOR OBTAINING SAME AND BIOCHEMICAL APPLICATIONS THEREOF
WO1988000618A1 (en) * 1986-07-10 1988-01-28 Toray Industries, Inc. Method of inspecting specimen for bacteria and probe therefor
US5541308A (en) * 1986-11-24 1996-07-30 Gen-Probe Incorporated Nucleic acid probes for detection and/or quantitation of non-viral organisms
AU616646B2 (en) * 1986-11-24 1991-11-07 Gen-Probe Incorporated Nucleic acid probes for detection and/or quantitation of non-viral organisms
DE3718591A1 (en) * 1987-06-03 1988-12-15 Behringwerke Ag AEUSSERES MEMBRANE PROTEIN F BY PSEUDOMONAS AERUGINOSA
AU1913288A (en) * 1987-07-24 1989-01-27 Universite Laval Dna probes for assaying b-lactamase production in gram-negative bacteria
JP2565552B2 (en) * 1987-10-15 1996-12-18 カイロン コーポレイション Nucleic acid multimer and amplified nucleic acid hybridization analysis method using the same
US5084565A (en) * 1988-08-18 1992-01-28 Gene-Trak Systems Probes for the specific detection of escherichia coli and shigella
FR2636075B1 (en) * 1988-09-07 1991-11-15 Biotechnologie Ste Europ METHOD FOR DETECTING BACTERIA, YEAST, PARASITES AND OTHER EUKARYOTS, ESPECIALLY IN FOOD PRODUCTS
US5041372A (en) * 1988-11-02 1991-08-20 The United States Of America As Represented By The Department Of Health And Human Services Probe to identify enteroinvasive E. coli and Shigella species
US5030556A (en) * 1989-03-30 1991-07-09 Danielle Beaulieu Species-specific DNNA probe for the detection of Branhamella catarrhalis
IE81145B1 (en) * 1989-04-20 2000-05-03 Thomas Gerard Barry Generation of specific probes for target nucleotide sequences
EP0426837B1 (en) * 1989-05-23 1995-09-06 Amoco Corporation Nucleic acid probes for the detection of staphylococcus aureus
WO1990015157A1 (en) * 1989-05-31 1990-12-13 Gene-Trak Systems Universal eubacteria nucleic acid probes and methods
US5334501A (en) * 1989-07-11 1994-08-02 Microprobe Corporation Quantification of bacteria using a nucleic acid hybridization assay
NL9002157A (en) * 1989-11-27 1991-06-17 U Gene Research Bv DNA FRAGMENTS AND DNA PROBES AND PRIMERS BASED ON THAT.
CA2075186A1 (en) * 1990-02-02 1991-08-03 Rudi Rossau Hybridization probes for the detection of branhamella catarrhalis strains
EP0452596A1 (en) * 1990-04-18 1991-10-23 N.V. Innogenetics S.A. Hybridization probes derived from the spacer region between the 16S and 23S rRNA genes for the detection of non-viral microorganisms
SE466259B (en) * 1990-05-31 1992-01-20 Arne Forsgren PROTEIN D - AN IGD BINDING PROTEIN FROM HAEMOPHILUS INFLUENZAE, AND THE USE OF THIS FOR ANALYSIS, VACCINES AND PURPOSE
EP0479117B1 (en) * 1990-10-05 2001-11-28 F. Hoffmann-La Roche Ag Methods and reagents for identifying gram negative bacteria
US5476929A (en) * 1991-02-15 1995-12-19 Uab Research Foundation Structural gene of pneumococcal protein
JP3215109B2 (en) * 1991-02-15 2001-10-02 ユーエイビー リサーチ ファウンデーション Structural gene of pneumococcal protein
US5980909A (en) * 1991-02-15 1999-11-09 Uab Research Foundation Epitopic regions of pneumococcal surface protein A
US5472843A (en) * 1991-04-25 1995-12-05 Gen-Probe Incorporated Nucleic acid probes to Haemophilus influenzae
US5232831A (en) * 1991-06-28 1993-08-03 Gen-Probe Incorporated Nucleic acid probes to streptococcus pyogenes
JPH0549477A (en) * 1991-08-05 1993-03-02 Wakunaga Pharmaceut Co Ltd Detection of bacteria of the genus staphylococcus
CA2075423A1 (en) * 1991-08-13 1993-02-14 Paul Luther Skatrud Rapid method for detection of methicillin resistant staphylococci
US5292874A (en) * 1991-09-04 1994-03-08 Gen-Probe Incorporated Nucleic acid probes to Staphylococcus aureus
FR2685334B1 (en) * 1991-12-23 1995-05-05 Bio Merieux POLYPEPTIDES CONTAINING CHARACTERISTIC SEQUENCES OF PYRROLIDONE CARBOXYLYL PEPTIDASES, POLYNUCLEOTIDES CONTAINING A SEQUENCE ENCODING SUCH POLYPEPTIDES, AND THEIR USE.
JPH0690798A (en) * 1992-02-05 1994-04-05 Toagosei Chem Ind Co Ltd Probe for detecting staphylococcus aureus and method for detecting the same
FR2687168B1 (en) * 1992-02-10 1994-03-25 Bio Merieux FRAGMENT OF STREPTOCOCCUS PNEUMONIAE GENOMIC DNA, HYBRIDIZATION PROBE, AMPLIFIER PRIME, REAGENT AND METHOD FOR DETECTION OF STREPTOCOCCUS PNEUMONIAE.
JPH0654700A (en) * 1992-05-19 1994-03-01 Mitsui Toatsu Chem Inc Highly sensitive detection of resistant bacterium
ATE304609T1 (en) * 1992-07-07 2005-09-15 Fuso Pharmaceutical Ind PROBE FOR DIAGNOSING AN INFECTIOUS DISEASE CAUSED BY ESCHERICHIA COLI, KLEBSIELLA PNEUMONIAE OR ENTEROBACTER CLOACAE
JPH06165681A (en) * 1992-12-02 1994-06-14 Toyobo Co Ltd Oligonucleotide for detection of methicillin resistant staphylococcus aureus, detection of methicillin resistant staphylococcus aureus and kit of detection reagent
FR2699539B1 (en) * 1992-12-18 1995-02-17 Pasteur Institut Protein conferring an inducible type resistance to glycopeptides, especially in gram-positive bacteria. Nucleotide sequence encoding this protein.
CA2141535A1 (en) * 1993-06-23 1995-01-05 Craig W. Adams Recombinant dnase b derived from streptococcus pyogenes
JP3499263B2 (en) * 1993-09-03 2004-02-23 株式会社紀文食品 Detection and nucleotide sequence of Klebsiella spp.
US5712118A (en) * 1993-09-29 1998-01-27 Research Foundation Of State University Of New York Vaccine for branhamella catarrhalis
US5599665A (en) * 1993-12-21 1997-02-04 Mcw Research Foundation Pseudomonas aeruginosa nucleic acids encoding exoenzyme S activity and use thereof in detecting pseudomonas aeruginosa infection
JP3525475B2 (en) * 1994-01-10 2004-05-10 恵 河野 Novel 'mecA protein, DNA encoding the same, and method for detecting methicillin-resistant Staphylococcus aureus using the same
US5582978A (en) * 1994-01-21 1996-12-10 Amoco Corporation Nucleic acid probes for the detection of Haemophilus influenzae
US5705332A (en) * 1994-04-25 1998-01-06 University Of Hawaii Detection and identification of Salmonella and Shigella
EP1098006A1 (en) * 1994-06-24 2001-05-09 Innogenetics N.V. Simultaneous detection, identification and differentiation of eubacterial taxa using a hybridization assay
AU706937B2 (en) * 1994-07-19 1999-07-01 Bactex Inc. LKP pilin structural genes and operon of nontypable haemophilus influenzae
US6001564A (en) * 1994-09-12 1999-12-14 Infectio Diagnostic, Inc. Species specific and universal DNA probes and amplification primers to rapidly detect and identify common bacterial pathogens and associated antibiotic resistance genes from clinical specimens for routine diagnosis in microbiology laboratories
US20020055101A1 (en) * 1995-09-11 2002-05-09 Michel G. Bergeron Specific and universal probes and amplification primers to rapidly detect and identify common bacterial pathogens and antibiotic resistance genes from clinical specimens for routine diagnosis in microbiology laboratories
US5652102A (en) * 1994-12-05 1997-07-29 The United States Of America As Represented By The Secretary Of Agriculture Assay for enterohemorrhagic Escherichia coli 0157:H7 by the polymerase chain reaction
US5686336A (en) * 1995-07-26 1997-11-11 Taiwan Semiconductor Manufacturing Company Ltd. Method of manufacture of four transistor SRAM cell layout
US20030049636A1 (en) * 1999-05-03 2003-03-13 Bergeron Michel G. Species-specific, genus-specific and universal DNA probes and amplification primers to rapidly detect and identify common bacterial and fungal pathogens and associated antibiotic resistance genes from clinical specimens for diagnosis in microbiology laboratories
EP1246935B1 (en) * 1999-09-28 2013-08-14 Geneohm Sciences Canada Inc. Highly conserved genes and their use to generate probes and primers for detection of microorganisms
US20070185478A1 (en) * 2006-02-08 2007-08-09 Plasiatherm, Inc. Device for local ablation of tissue

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0438115A2 (en) * 1990-01-19 1991-07-24 F. Hoffmann-La Roche Ag Process for detection of water-borne microbial pathogens and indicators of human fecal contamination in water samples and kits therefor
WO1993003186A1 (en) * 1991-07-31 1993-02-18 F.Hoffmann-La Roche Ag Methods and reagents for detection of bacteria in cerebrospinal fluid
WO1994002645A1 (en) * 1992-07-17 1994-02-03 Aprogenex, Inc. Rapid detection of biopolymers in stained specimens

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