WO1996013284A1 - Composition de traitement de lesions - Google Patents
Composition de traitement de lesions Download PDFInfo
- Publication number
- WO1996013284A1 WO1996013284A1 PCT/GB1995/002542 GB9502542W WO9613284A1 WO 1996013284 A1 WO1996013284 A1 WO 1996013284A1 GB 9502542 W GB9502542 W GB 9502542W WO 9613284 A1 WO9613284 A1 WO 9613284A1
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- composition
- nocc
- occ
- plasticiser
- weight
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
- A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
- A61L15/22—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons containing macromolecular materials
- A61L15/28—Polysaccharides or their derivatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L26/00—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form
- A61L26/0009—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form containing macromolecular materials
- A61L26/0023—Polysaccharides
Definitions
- the present invention relates to compositions which are useful in the treatment
- the invention relates more particularly to such compositions which
- OCC O-carboxymethyl chitosan
- NOCC is a known material and its preparation is disclosed for example in US-
- NOCC may be prepared by a solid phase reaction between
- OCC may be produced by a similar
- composition for use in treating a wound comprising a hydrogel containing OCC or
- compositions in accordance with the invention are useful in the treatment of
- a film having a high MVTR typically 3,000 to 12.000 g m “2 24hr " ' (e.g.
- compositions may also be used in the treatment of sinuses.
- compositions in accordance with the invention have a viscosity in the
- compositions in accordance with the invention will generally contain a
- OCC OCC
- NOCC NOCC
- the plasticiser will generally be present in a maximum amount of 20% by
- plasticiser examples include polyhydroxy compounds, e.g. glycerol, sorbitol,
- propylene glycol and polyethylene glycol (a preferred example of which is PEG 400).
- the most preferred plasticiser glycerol glycerol.
- the aqueous phase of the gel will for preference comprise isotonic buffered saline, e.g. phosphate buffered saline.
- Additional components may be included in the composition to enhance their functionality
- antimicrobial agents which may be used at a level
- a preferred anti-microbial agent is chlorhexidine
- Antimicrobial properties may also be achieved by use of enzymes, e.g. glucose
- a further possibility is to include a component, e.g. pectin, which facilitates
- This component may for example be used in an amount up to
- compositions for use in accordance with the invention may be produced in
- compositions may be produced by dissolving the required amounts of OCC or NOCC (e.g. 3-5%), plasticiser and any other components in
- composition may be sterilised by
- the gels obtained may be incorporated into a convenient delivery system, e.g. a
- the invention is illustrated by the following non-limiting Example.
- a gel was produced by dissolving 3-4% NOCC and 1 -2% high methoxy pectin
Abstract
Cette composition, utile dans le traitement d'une lésion, par exemple des lésions creuses, comprend un hydrogel contenant du O-carboxyméthyle chitosane ou du N,O-carboxyméthyle chitosane ainsi qu'un composé plastifiant.
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
AU37503/95A AU3750395A (en) | 1994-10-28 | 1995-10-30 | Wound treatment composition |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GB9421969A GB9421969D0 (en) | 1994-10-28 | 1994-10-28 | Wound treatment composition |
GB9421969.8 | 1994-10-28 |
Publications (1)
Publication Number | Publication Date |
---|---|
WO1996013284A1 true WO1996013284A1 (fr) | 1996-05-09 |
Family
ID=10763689
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/GB1995/002542 WO1996013284A1 (fr) | 1994-10-28 | 1995-10-30 | Composition de traitement de lesions |
Country Status (3)
Country | Link |
---|---|
AU (1) | AU3750395A (fr) |
GB (1) | GB9421969D0 (fr) |
WO (1) | WO1996013284A1 (fr) |
Cited By (11)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1997003710A1 (fr) * | 1995-07-19 | 1997-02-06 | Innovative Technologies Limited | Composition cicatrisante |
WO1998050050A1 (fr) * | 1997-05-06 | 1998-11-12 | Chitogenics, Inc. | N, o-carboxymethyl-chitosane a liaison covalente et ses applications |
US6124273A (en) * | 1995-06-09 | 2000-09-26 | Chitogenics, Inc. | Chitin hydrogels, methods of their production and use |
US6645947B1 (en) | 1999-05-20 | 2003-11-11 | Chitogenics, Inc. | Adhesive N, O-carboxymethylchitosan coatings which inhibit attachment of substrate-dependent cells and proteins |
WO2006034688A1 (fr) * | 2004-09-27 | 2006-04-06 | Universität Hamburg | Procede de production d'un pansement |
US7265097B2 (en) | 2002-08-20 | 2007-09-04 | Chitogenics, Inc. | Methods of drug delivery using sulphated chitinous polymers |
WO2015061606A1 (fr) * | 2013-10-24 | 2015-04-30 | Medtronic Xomed, Inc. | Pâte d'occlusion au chitosane |
US9192692B2 (en) | 2013-10-24 | 2015-11-24 | Medtronic Xomed, Inc. | Chitosan stenting paste |
US9970303B2 (en) | 2014-05-13 | 2018-05-15 | Entrotech, Inc. | Erosion protection sleeve |
CN111135338A (zh) * | 2019-12-31 | 2020-05-12 | 瑞希(重庆)生物科技有限公司 | 一种止血凝胶及其制备方法 |
US10926000B2 (en) | 2016-05-13 | 2021-02-23 | Colorado School Of Mines | Deposition-conversion method for tunable calcium phosphate coatings on substrates and apparatus prepared thereof |
Citations (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3903268A (en) * | 1968-02-12 | 1975-09-02 | Lescarden Ltd | Chitin and chitin derivatives for promoting wound healing |
US4659700A (en) * | 1984-03-02 | 1987-04-21 | Johnson & Johnson Products, Inc. | Chitosan-glycerol-water gel |
EP0356060A2 (fr) * | 1988-08-18 | 1990-02-28 | Minnesota Mining And Manufacturing Company | Composition pour remplir des blessures |
EP0426368A2 (fr) * | 1989-10-31 | 1991-05-08 | Howmedica Inc. | Compositions contenant des dérivés de chitine pour empêcher l'adhésion |
-
1994
- 1994-10-28 GB GB9421969A patent/GB9421969D0/en active Pending
-
1995
- 1995-10-30 AU AU37503/95A patent/AU3750395A/en not_active Abandoned
- 1995-10-30 WO PCT/GB1995/002542 patent/WO1996013284A1/fr active Application Filing
Patent Citations (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3903268A (en) * | 1968-02-12 | 1975-09-02 | Lescarden Ltd | Chitin and chitin derivatives for promoting wound healing |
US4659700A (en) * | 1984-03-02 | 1987-04-21 | Johnson & Johnson Products, Inc. | Chitosan-glycerol-water gel |
EP0356060A2 (fr) * | 1988-08-18 | 1990-02-28 | Minnesota Mining And Manufacturing Company | Composition pour remplir des blessures |
EP0426368A2 (fr) * | 1989-10-31 | 1991-05-08 | Howmedica Inc. | Compositions contenant des dérivés de chitine pour empêcher l'adhésion |
Non-Patent Citations (1)
Title |
---|
R.A.A.MUZZARELLI ET AL.: "N-CARBOXYBUTYL CHITOSAN AND FIBRIN GLUE IN CUTANEOUS REPAIR PROCESSES", JOURNAL OF BIOACTIVE AND COMPATIBLE POLYMERS, vol. 5, no. 4, US, pages 396 - 410, XP000213548 * |
Cited By (17)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6124273A (en) * | 1995-06-09 | 2000-09-26 | Chitogenics, Inc. | Chitin hydrogels, methods of their production and use |
WO1997003710A1 (fr) * | 1995-07-19 | 1997-02-06 | Innovative Technologies Limited | Composition cicatrisante |
WO1998050050A1 (fr) * | 1997-05-06 | 1998-11-12 | Chitogenics, Inc. | N, o-carboxymethyl-chitosane a liaison covalente et ses applications |
US7238678B2 (en) * | 1999-05-20 | 2007-07-03 | Chitogenics, Inc. | Adhesive N,O-carboxymethylchitosan coatings which inhibit attachment of substrate-dependent cells and proteins |
US6645947B1 (en) | 1999-05-20 | 2003-11-11 | Chitogenics, Inc. | Adhesive N, O-carboxymethylchitosan coatings which inhibit attachment of substrate-dependent cells and proteins |
US6809085B1 (en) | 1999-05-20 | 2004-10-26 | Chitogenics, Inc. | Adherent N,O-Carboxymethylchitosan drug delivery devices for moist tissue and methods of their use |
US6894035B2 (en) * | 1999-05-20 | 2005-05-17 | Chitogenics, Inc. | Adhesive N,O-carboxymethylchitosan coatings which inhibit attachment of substrate-dependent cells and proteins |
US7265097B2 (en) | 2002-08-20 | 2007-09-04 | Chitogenics, Inc. | Methods of drug delivery using sulphated chitinous polymers |
WO2006034688A1 (fr) * | 2004-09-27 | 2006-04-06 | Universität Hamburg | Procede de production d'un pansement |
WO2015061606A1 (fr) * | 2013-10-24 | 2015-04-30 | Medtronic Xomed, Inc. | Pâte d'occlusion au chitosane |
US9192692B2 (en) | 2013-10-24 | 2015-11-24 | Medtronic Xomed, Inc. | Chitosan stenting paste |
US9192574B2 (en) | 2013-10-24 | 2015-11-24 | Medtronic Xomed, Inc. | Chitosan paste wound dressing |
JP2016533775A (ja) * | 2013-10-24 | 2016-11-04 | メドトロニック・ゾーメド・インコーポレーテッド | キトサンペースト創傷手当て材 |
AU2014340006B2 (en) * | 2013-10-24 | 2018-06-28 | Medtronic Xomed, Inc. | Chitosan stenting paste |
US9970303B2 (en) | 2014-05-13 | 2018-05-15 | Entrotech, Inc. | Erosion protection sleeve |
US10926000B2 (en) | 2016-05-13 | 2021-02-23 | Colorado School Of Mines | Deposition-conversion method for tunable calcium phosphate coatings on substrates and apparatus prepared thereof |
CN111135338A (zh) * | 2019-12-31 | 2020-05-12 | 瑞希(重庆)生物科技有限公司 | 一种止血凝胶及其制备方法 |
Also Published As
Publication number | Publication date |
---|---|
GB9421969D0 (en) | 1994-12-21 |
AU3750395A (en) | 1996-05-23 |
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